JP5689416B2 - 超音波仲介による薬送達 - Google Patents

超音波仲介による薬送達 Download PDF

Info

Publication number
JP5689416B2
JP5689416B2 JP2011519256A JP2011519256A JP5689416B2 JP 5689416 B2 JP5689416 B2 JP 5689416B2 JP 2011519256 A JP2011519256 A JP 2011519256A JP 2011519256 A JP2011519256 A JP 2011519256A JP 5689416 B2 JP5689416 B2 JP 5689416B2
Authority
JP
Japan
Prior art keywords
ultrasound
particles
drug
imaging
shell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2011519256A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011529039A (ja
JP2011529039A5 (enExample
Inventor
ウィリアム シ
ウィリアム シ
チエン チン チン
チエン チン チン
クリストファ ハール
クリストファ ハール
バラスンダラ ラジュ
バラスンダラ ラジュ
マーセル ボーマー
マーセル ボーマー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Koninklijke Philips Electronics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV, Koninklijke Philips Electronics NV filed Critical Koninklijke Philips NV
Publication of JP2011529039A publication Critical patent/JP2011529039A/ja
Publication of JP2011529039A5 publication Critical patent/JP2011529039A5/ja
Application granted granted Critical
Publication of JP5689416B2 publication Critical patent/JP5689416B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Radiology & Medical Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2011519256A 2008-07-23 2009-06-09 超音波仲介による薬送達 Active JP5689416B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6169008P 2008-07-23 2008-07-23
US61/061,690 2008-07-23
PCT/IB2009/052449 WO2010010473A1 (en) 2008-07-23 2009-06-09 Ultrasound mediated drug delivery

Publications (3)

Publication Number Publication Date
JP2011529039A JP2011529039A (ja) 2011-12-01
JP2011529039A5 JP2011529039A5 (enExample) 2012-07-26
JP5689416B2 true JP5689416B2 (ja) 2015-03-25

Family

ID=40848700

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011519256A Active JP5689416B2 (ja) 2008-07-23 2009-06-09 超音波仲介による薬送達

Country Status (5)

Country Link
US (1) US20110125080A1 (enExample)
EP (1) EP2318086B1 (enExample)
JP (1) JP5689416B2 (enExample)
CN (1) CN102112176B (enExample)
WO (1) WO2010010473A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
US9125979B2 (en) 2007-10-25 2015-09-08 Proteus Digital Health, Inc. Fluid transfer port information system
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
EP2531096A4 (en) 2010-02-01 2013-09-11 Proteus Digital Health Inc DATA COLLECTION SYSTEM FOR TWO WRIST
SG182825A1 (en) 2010-02-01 2012-09-27 Proteus Biomedical Inc Data gathering system
CN103826692B (zh) * 2011-09-28 2016-06-22 皇家飞利浦有限公司 自动化超声介导递送
JP6313705B2 (ja) * 2011-09-29 2018-04-18 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 重要臓器保護を伴う超音波媒介送達
TWI405583B (zh) * 2011-11-03 2013-08-21 Taipei City Hospital Contrast Agent Enhances the Quantification of Ultrasound in Drug Delivery
CN103055302B (zh) * 2013-01-08 2014-05-14 福建医科大学附属协和医院 一种超声生物效应介导的重组人血管内皮抑制素控释制剂
US20180008534A1 (en) * 2014-12-08 2018-01-11 Robert B. Lomerson Method for preventing, treating, and curing cancer
EP3302443A4 (en) 2015-06-01 2019-02-13 The Trustees Of The University Of Pennsylvania MECHANO SENSITIVE MICRO CAPSULES FOR DRUG DELIVERY
WO2016210136A2 (en) * 2015-06-23 2016-12-29 Advanced Csf Therapies, Llc Methods and system for ultrasonic targeted drug delivery in cystic fluids, such as the cerebrospinal fluid, using buoyancy specific drug carriers
JP7053463B2 (ja) * 2015-11-11 2022-04-12 ナビフス コーポレーション リミテッド 超音波システムを使用して脳腫瘍を治療するための方法及びキット
US11369810B2 (en) * 2016-12-19 2022-06-28 Michalakis Averkiou Method and apparatus for ultrasonic mediation of drug delivery using microbubbles
JP7289061B2 (ja) * 2017-06-29 2023-06-09 インサイテック リミテッド シミュレーションベースの薬物処置計画
US12121597B2 (en) 2018-10-19 2024-10-22 The Board Of Trustees Of The University Of Illinois High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
US11786215B2 (en) * 2019-01-23 2023-10-17 Washington University Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent
CA3177232A1 (en) * 2020-06-15 2021-12-23 Bracco Suisse Sa Improvements in ultrasound-mediated therapy
CN112263789B (zh) * 2020-09-18 2025-08-05 北京万孛力医疗器械有限公司 一种调节雄性哺乳动物睾酮水平的装置
WO2025129071A1 (en) * 2023-12-14 2025-06-19 Sonothera, Inc. Methods and systems for improved nucleic acid delivery via ultrasound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461789A (en) * 1973-04-12 1977-01-19 Lilly Industries Ltd 3-substituted propanoic acid derivatives
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
US6135971A (en) * 1995-11-09 2000-10-24 Brigham And Women's Hospital Apparatus for deposition of ultrasound energy in body tissue
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6322532B1 (en) * 1998-06-24 2001-11-27 3M Innovative Properties Company Sonophoresis method and apparatus
JP4070339B2 (ja) * 1999-01-20 2008-04-02 ジーイー横河メディカルシステム株式会社 超音波撮像装置
US6712805B2 (en) * 2001-01-29 2004-03-30 Ultra Sonic Tech Llc Method and apparatus for intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound
US6716168B2 (en) 2002-04-30 2004-04-06 Siemens Medical Solutions Usa, Inc. Ultrasound drug delivery enhancement and imaging systems and methods
US7695515B2 (en) 2003-07-15 2010-04-13 Spinal Generations, Llc Spinal disc prosthesis system
CN1909931B (zh) * 2004-01-15 2011-01-12 皇家飞利浦电子股份有限公司 用于分子成像的超声造影剂
US20080019904A1 (en) * 2004-06-29 2008-01-24 Koninklijke Philips Electronics, N.V. System For Manufacturing Micro-Sheres
US8932239B2 (en) 2005-06-07 2015-01-13 Koninklijke Philips N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
JPWO2008081556A1 (ja) * 2007-01-05 2010-04-30 株式会社島津製作所 超音波装置

Also Published As

Publication number Publication date
JP2011529039A (ja) 2011-12-01
EP2318086B1 (en) 2016-04-13
EP2318086A1 (en) 2011-05-11
WO2010010473A1 (en) 2010-01-28
CN102112176A (zh) 2011-06-29
US20110125080A1 (en) 2011-05-26
CN102112176B (zh) 2015-08-12

Similar Documents

Publication Publication Date Title
JP5689416B2 (ja) 超音波仲介による薬送達
US6352683B1 (en) Apparatus and method for the local delivery of drugs
Yuh et al. Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: study in a murine model
Abenojar et al. Effect of bubble concentration on the in vitro and in vivo performance of highly stable lipid shell-stabilized micro-and nanoscale ultrasound contrast agents
Hernot et al. Microbubbles in ultrasound-triggered drug and gene delivery
Klibanov Microbubble contrast agents: targeted ultrasound imaging and ultrasound-assisted drug-delivery applications
Liu et al. Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery
Yildirim et al. Colloids, nanoparticles, and materials for imaging, delivery, ablation, and theranostics by focused ultrasound (FUS)
JP4772958B2 (ja) 生物学的に活性な媒質の標的に向けた送達
US20030147812A1 (en) Device and methods for initiating chemical reactions and for the targeted delivery of drugs or other agents
JP6595991B2 (ja) キャビテーションを誘発するポリマーナノ粒子
Udroiu Ultrasonic drug delivery in Oncology
JP2007513866A (ja) 薬物送達カプセルの超音波濃縮
US20080269163A1 (en) Methods and Compositions for Protecting Cells from Ultrasound-Mediated Cytolysis
Gharat et al. Microbubbles contrast agents: general overview as diagnostics and therapeutic agent
Tsirkin et al. Tailor-made single-core PLGA microbubbles as acoustic cavitation enhancers for therapeutic applications
US20100221190A1 (en) Method for producing a particle comprising a gas core and a shell and particles thus obtained
Wawryka et al. Microbubble based sonoporation—from the basics into clinical implications
Palekar-Shanbhag et al. Microbubbles and their applications in pharmaceutical targeting
Zarchi et al. A study on the possibility of drug delivery approach through ultrasonic sensitive nanocarriers
Ahmed Dynamics of chemotherapeutic drug release from liposomes using low-frequency ultrasound
Huang et al. Ultrasound for drug/gene delivery
Caskey et al. Ultrasound mediated drug delivery: the effect of microbubbles on a gel boundary
US20230277696A1 (en) Ultrasound-sensitive biodegradeable multi-cavity micro-particles
Zhang Intravascular Sonothrombolysis with Magnetic Microbubbles and Nanodroplets

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120607

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120607

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131120

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140219

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140408

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20140804

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20140822

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20140916

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20141202

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150105

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20150128

R150 Certificate of patent or registration of utility model

Ref document number: 5689416

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250