JP5689416B2 - 超音波仲介による薬送達 - Google Patents

超音波仲介による薬送達 Download PDF

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Publication number
JP5689416B2
JP5689416B2 JP2011519256A JP2011519256A JP5689416B2 JP 5689416 B2 JP5689416 B2 JP 5689416B2 JP 2011519256 A JP2011519256 A JP 2011519256A JP 2011519256 A JP2011519256 A JP 2011519256A JP 5689416 B2 JP5689416 B2 JP 5689416B2
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ultrasound
particles
drug
imaging
shell
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Japanese (ja)
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JP2011529039A (ja
JP2011529039A5 (enExample
Inventor
ウィリアム シ
ウィリアム シ
チエン チン チン
チエン チン チン
クリストファ ハール
クリストファ ハール
バラスンダラ ラジュ
バラスンダラ ラジュ
マーセル ボーマー
マーセル ボーマー
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Koninklijke Philips NV
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Koninklijke Philips NV
Koninklijke Philips Electronics NV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
JP2011519256A 2008-07-23 2009-06-09 超音波仲介による薬送達 Active JP5689416B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6169008P 2008-07-23 2008-07-23
US61/061,690 2008-07-23
PCT/IB2009/052449 WO2010010473A1 (en) 2008-07-23 2009-06-09 Ultrasound mediated drug delivery

Publications (3)

Publication Number Publication Date
JP2011529039A JP2011529039A (ja) 2011-12-01
JP2011529039A5 JP2011529039A5 (enExample) 2012-07-26
JP5689416B2 true JP5689416B2 (ja) 2015-03-25

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Family Applications (1)

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JP2011519256A Active JP5689416B2 (ja) 2008-07-23 2009-06-09 超音波仲介による薬送達

Country Status (5)

Country Link
US (1) US20110125080A1 (enExample)
EP (1) EP2318086B1 (enExample)
JP (1) JP5689416B2 (enExample)
CN (1) CN102112176B (enExample)
WO (1) WO2010010473A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5241714B2 (ja) 2006-07-07 2013-07-17 プロテウス デジタル ヘルス， インコーポレイテッド スマートな非経口送達システム
EP2211974A4 (en) 2007-10-25 2013-02-27 Proteus Digital Health Inc INFORMATION SYSTEM FOR LIQUID FLOW CHANNEL
WO2009067463A1 (en) 2007-11-19 2009-05-28 Proteus Biomedical, Inc. Body-associated fluid transport structure evaluation devices
AU2011210648B2 (en) 2010-02-01 2014-10-16 Otsuka Pharmaceutical Co., Ltd. Data gathering system
MY169700A (en) 2010-02-01 2019-05-13 Proteus Digital Health Inc Data gathering system
WO2013046076A1 (en) * 2011-09-28 2013-04-04 Koninklijke Philips Electronics N.V. Automated ultrasound mediated delivery.
EP2744560B1 (en) * 2011-09-29 2020-06-17 Koninklijke Philips N.V. Ultrasound mediated delivery with critical-organ protection
TWI405583B (zh) * 2011-11-03 2013-08-21 Taipei City Hospital Contrast Agent Enhances the Quantification of Ultrasound in Drug Delivery
CN103055302B (zh) * 2013-01-08 2014-05-14 福建医科大学附属协和医院 一种超声生物效应介导的重组人血管内皮抑制素控释制剂
WO2016094324A1 (en) * 2014-12-08 2016-06-16 Lomerson Robert B Method for preventing, treating, and curing cancer
WO2016196598A1 (en) 2015-06-01 2016-12-08 The Trustees Of The University Of Pennsylvania Mechano-sensitive microcapsules for drug delivery
WO2016210136A2 (en) * 2015-06-23 2016-12-29 Advanced Csf Therapies, Llc Methods and system for ultrasonic targeted drug delivery in cystic fluids, such as the cerebrospinal fluid, using buoyancy specific drug carriers
WO2017080481A1 (en) * 2015-11-11 2017-05-18 Navifus Co., Ltd. Method and kit for treating brain tumor by using ultrasound system
US11369810B2 (en) * 2016-12-19 2022-06-28 Michalakis Averkiou Method and apparatus for ultrasonic mediation of drug delivery using microbubbles
CN111032157B (zh) * 2017-06-29 2023-04-21 医视特有限公司 基于模拟的药物治疗计划
US12121597B2 (en) 2018-10-19 2024-10-22 The Board Of Trustees Of The University Of Illinois High-intensity focused ultrasound-induced mechanochemical transduction in synthetic elastomers
US11786215B2 (en) * 2019-01-23 2023-10-17 Washington University Methods of detecting, measuring, or imaging a concentration or location of a therapeutic agent
CN115734786A (zh) * 2020-06-15 2023-03-03 博莱科瑞士股份有限公司 超声介导治疗的改进
CA3185803A1 (en) 2020-08-07 2022-02-10 Vijay Agarwal Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
CN112263789B (zh) * 2020-09-18 2025-08-05 北京万孛力医疗器械有限公司 一种调节雄性哺乳动物睾酮水平的装置
AU2024398257A1 (en) * 2023-12-14 2026-07-09 Sonothera, Inc. Methods and systems for improved nucleic acid delivery via ultrasound

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1461789A (en) * 1973-04-12 1977-01-19 Lilly Industries Ltd 3-substituted propanoic acid derivatives
US5618275A (en) * 1995-10-27 1997-04-08 Sonex International Corporation Ultrasonic method and apparatus for cosmetic and dermatological applications
US6135971A (en) * 1995-11-09 2000-10-24 Brigham And Women's Hospital Apparatus for deposition of ultrasound energy in body tissue
GB9701237D0 (en) * 1997-01-22 1997-03-12 Nycomed Imaging As Improvements in or relating to contrast agents
US6322532B1 (en) * 1998-06-24 2001-11-27 3M Innovative Properties Company Sonophoresis method and apparatus
JP4070339B2 (ja) * 1999-01-20 2008-04-02 ジーイー横河メディカルシステム株式会社 超音波撮像装置
US6712805B2 (en) * 2001-01-29 2004-03-30 Ultra Sonic Tech Llc Method and apparatus for intradermal incorporation of microparticles containing encapsulated drugs using low frequency ultrasound
US6716168B2 (en) 2002-04-30 2004-04-06 Siemens Medical Solutions Usa, Inc. Ultrasound drug delivery enhancement and imaging systems and methods
US7695515B2 (en) 2003-07-15 2010-04-13 Spinal Generations, Llc Spinal disc prosthesis system
WO2005070473A1 (en) * 2004-01-15 2005-08-04 Koninklijke Philips Electronics N.V. Ultrasound contrast agents for molecular imaging
WO2006003581A1 (en) * 2004-06-29 2006-01-12 Koninklijke Philips Electronics N.V. System for manufacturing micro-spheres
US8932239B2 (en) 2005-06-07 2015-01-13 Koninklijke Philips N.V. Method and apparatus for ultrasound drug delivery and thermal therapy with phase-convertible fluids
JPWO2008081556A1 (ja) * 2007-01-05 2010-04-30 株式会社島津製作所 超音波装置

Also Published As

Publication number Publication date
US20110125080A1 (en) 2011-05-26
JP2011529039A (ja) 2011-12-01
CN102112176A (zh) 2011-06-29
WO2010010473A1 (en) 2010-01-28
CN102112176B (zh) 2015-08-12
EP2318086B1 (en) 2016-04-13
EP2318086A1 (en) 2011-05-11

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