CN102112121A - 用于治疗疼痛和瘙痒的方法、组合物和药盒 - Google Patents

用于治疗疼痛和瘙痒的方法、组合物和药盒 Download PDF

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Publication number
CN102112121A
CN102112121A CN200980117485XA CN200980117485A CN102112121A CN 102112121 A CN102112121 A CN 102112121A CN 200980117485X A CN200980117485X A CN 200980117485XA CN 200980117485 A CN200980117485 A CN 200980117485A CN 102112121 A CN102112121 A CN 102112121A
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CN
China
Prior art keywords
compound
channel
pain
voltage
inhibits
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Pending
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CN200980117485XA
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English (en)
Chinese (zh)
Inventor
B·P·比恩
C·J·伍尔夫
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General Hospital Corp
Harvard University
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General Hospital Corp
Harvard University
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Publication of CN102112121A publication Critical patent/CN102112121A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN200980117485XA 2008-03-11 2009-03-11 用于治疗疼痛和瘙痒的方法、组合物和药盒 Pending CN102112121A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6901808P 2008-03-11 2008-03-11
US61/069018 2008-03-11
PCT/US2009/001541 WO2009114139A2 (en) 2008-03-11 2009-03-11 Methods, compositions, and kits for treating pain and pruritis

Publications (1)

Publication Number Publication Date
CN102112121A true CN102112121A (zh) 2011-06-29

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ID=41065720

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980117485XA Pending CN102112121A (zh) 2008-03-11 2009-03-11 用于治疗疼痛和瘙痒的方法、组合物和药盒

Country Status (11)

Country Link
US (1) US20110086818A1 (https=)
EP (1) EP2271329A4 (https=)
JP (1) JP2011513484A (https=)
KR (1) KR20110044166A (https=)
CN (1) CN102112121A (https=)
AU (1) AU2009223739A1 (https=)
BR (1) BRPI0909627A2 (https=)
CA (1) CA2717042A1 (https=)
IL (1) IL208027A0 (https=)
MX (1) MX2010009951A (https=)
WO (1) WO2009114139A2 (https=)

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CN106214678A (zh) * 2016-07-26 2016-12-14 上海璃道医药科技有限公司 苯酮类药物的新用途
CN113509457A (zh) * 2020-09-07 2021-10-19 四川大学华西医院 山椒素在制备治疗湿疹的药物中的用途
CN113811305A (zh) * 2019-03-11 2021-12-17 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
CN115279731A (zh) * 2020-03-11 2022-11-01 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法

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JP6205133B2 (ja) 2009-07-10 2017-09-27 プレジデント アンド フェローズ オブ ハーバード カレッジ 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
JP5832856B2 (ja) * 2010-12-15 2015-12-16 久光製薬株式会社 局所鎮痛作用増強剤及び局所鎮痛キット
UA112769C2 (uk) 2011-02-18 2016-10-25 Ендо Фармасьютікалз Інк. Аміноінданові сполуки і їх застосування при лікуванні болю
HUE032240T2 (en) 2011-10-24 2017-09-28 Asana Biosciences Llc cyclohexylamines
US8779003B2 (en) 2011-12-29 2014-07-15 Mackay Memorial Hospital Method and composition for prolonging analgesic effect of local anesthetic
WO2014028675A1 (en) 2012-08-15 2014-02-20 Endo Pharmaceuticals Inc. Use of aminoindane compounds in treating overactive bladder and interstitial cystitis
ES2925071T3 (es) * 2013-02-08 2022-10-13 Gen Mills Inc Productos alimentarios reducidos en sodio
US20170042834A1 (en) * 2014-04-14 2017-02-16 Flex Pharma, Inc. Ion channel activators and methods of use
AU2016301282B2 (en) * 2015-08-03 2022-03-17 Children's Medical Center Corporation Charged ion channel blockers and methods for use
WO2018136943A1 (en) 2017-01-23 2018-07-26 Flex Pharma, Inc. Compositions and methods affecting exercise performance
KR101877002B1 (ko) * 2017-03-06 2018-07-12 서울대학교 산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법
KR101867779B1 (ko) * 2017-12-08 2018-06-19 서울대학교산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법
US11591375B2 (en) * 2018-01-22 2023-02-28 Oregon State University Immunogenic compositions comprising Mycobacterium bovis surface proteins and uses thereof
WO2019173394A1 (en) 2018-03-05 2019-09-12 Wylder Nation Foundation Compositions and methods for activating signaling through the cb1 cannabinoid receptor for treating and preventing diseases and disorders characterized by abnormal cellular accumulation of sphingolipids such as sphingomyelin
CN112703036B (zh) * 2018-08-15 2025-05-27 法玛西尔有限公司 取代的苯甲酰胺及其在疗法中的用途
CN109498604A (zh) * 2018-12-24 2019-03-22 复旦大学 香叶醇新用途，预防和治疗非疾病引起的瘙痒症的配制品及方法
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112021017809A2 (pt) 2019-03-11 2021-11-23 Nocion Therapeutics Inc Bloqueadores de canais iônicos substituídos por éster e métodos para uso
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
AU2020234961C1 (en) 2019-03-11 2025-08-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
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US20230165812A1 (en) * 2020-02-27 2023-06-01 President And Fellows Of Harvard College Nociceptor neurons control cancer immunosurveillance
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106214678A (zh) * 2016-07-26 2016-12-14 上海璃道医药科技有限公司 苯酮类药物的新用途
CN113811305A (zh) * 2019-03-11 2021-12-17 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
CN115279731A (zh) * 2020-03-11 2022-11-01 诺西恩医疗公司 带电的离子通道阻滞剂及其使用方法
CN113509457A (zh) * 2020-09-07 2021-10-19 四川大学华西医院 山椒素在制备治疗湿疹的药物中的用途

Also Published As

Publication number Publication date
KR20110044166A (ko) 2011-04-28
US20110086818A1 (en) 2011-04-14
AU2009223739A1 (en) 2009-09-17
EP2271329A4 (en) 2013-01-09
WO2009114139A2 (en) 2009-09-17
IL208027A0 (en) 2010-12-30
WO2009114139A3 (en) 2009-12-23
MX2010009951A (es) 2011-09-01
BRPI0909627A2 (pt) 2018-04-10
CA2717042A1 (en) 2009-09-17
JP2011513484A (ja) 2011-04-28
EP2271329A2 (en) 2011-01-12

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