CN102088965B - 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 - Google Patents

水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 Download PDF

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CN102088965B
CN102088965B CN2009801273287A CN200980127328A CN102088965B CN 102088965 B CN102088965 B CN 102088965B CN 2009801273287 A CN2009801273287 A CN 2009801273287A CN 200980127328 A CN200980127328 A CN 200980127328A CN 102088965 B CN102088965 B CN 102088965B
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compound
patient
hydrogen
alkyl
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CN102088965A (zh
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亚历克.梅因
卢克.马蒂克劳泽尔
埃里克.马约克斯
西尔维亚.加西亚维森特
马塔.塞拉诺穆诺兹
安东尼奥.佐尔扎诺奥拉特
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Genmedica Therapeutics SL
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN2009801273287A 2008-05-13 2009-05-13 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 Expired - Fee Related CN102088965B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5283908P 2008-05-13 2008-05-13
US61/052,839 2008-05-13
PCT/EP2009/055788 WO2009138437A1 (en) 2008-05-13 2009-05-13 Salicylate conjugates useful for treating metabolic disorders

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CN2013101223642A Division CN103251631A (zh) 2008-05-13 2009-05-13 用于治疗代谢性病症的水杨酸盐(酯)缀合物

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CN102088965A CN102088965A (zh) 2011-06-08
CN102088965B true CN102088965B (zh) 2013-05-08

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CN2013101223642A Pending CN103251631A (zh) 2008-05-13 2009-05-13 用于治疗代谢性病症的水杨酸盐(酯)缀合物

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US (2) US20090298923A1 (enExample)
EP (1) EP2291182A1 (enExample)
JP (1) JP5669729B2 (enExample)
CN (2) CN102088965B (enExample)
AU (1) AU2009248057B2 (enExample)
BR (1) BRPI0912716A2 (enExample)
CA (1) CA2724023C (enExample)
WO (1) WO2009138437A1 (enExample)

Families Citing this family (10)

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US9085527B2 (en) 2008-07-08 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid acylated salicylates and their uses
CA2729186C (en) 2008-07-08 2018-01-16 Catabasis Pharmaceuticals, Inc. Fatty acid acetylated salicylates and their uses
CN102427809B (zh) * 2009-03-16 2014-10-01 根梅迪卡治疗公司 用于治疗代谢性疾病的抗炎剂和抗氧化剂轭合物
US8946451B2 (en) * 2009-10-05 2015-02-03 Catabasis Pharmaceuticals, Inc. Lipoic acid acylated salicylate derivatives and their uses
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
US8440723B2 (en) * 2011-05-11 2013-05-14 Banavara L. Mylari Metformin salts of salicylic acid and its congeners
CN108295262A (zh) * 2011-09-16 2018-07-20 根梅迪卡治疗公司 用于治疗代谢障碍的含抗炎剂和抗氧化剂缀合物的药物组合
WO2013037984A1 (en) * 2011-09-16 2013-03-21 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
MA53188A1 (fr) * 2018-10-11 2021-12-31 Basf As Composés aromatiques et leurs utilisations pharmaceutiques
CN109761815A (zh) * 2019-02-26 2019-05-17 首都医科大学附属北京天坛医院 一种基于白藜芦醇治疗神经系统疾病的化合物及制备方法

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