CN102086442A - Biosynthetic gene clusters of halogen-containing ansamycins - Google Patents

Biosynthetic gene clusters of halogen-containing ansamycins Download PDF

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CN102086442A
CN102086442A CN2009102257692A CN200910225769A CN102086442A CN 102086442 A CN102086442 A CN 102086442A CN 2009102257692 A CN2009102257692 A CN 2009102257692A CN 200910225769 A CN200910225769 A CN 200910225769A CN 102086442 A CN102086442 A CN 102086442A
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徐俊
肖静
许丽
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Third Institute of Oceanography SOA
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Third Institute of Oceanography SOA
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Abstract

The invention relates to biosynthetic gene clusters of halogen-containing ansamycins. Codes are comprehensively applied to catalyze conserved sequences of biosynthetic genes of biosynthetic antibiotics such as halogenase, polyketide synthase and the like of halogenated natural products into probes, and biosynthetic gene clusters of halogenated ansamycins are cloned from Mangrove endophyte streptomyces sp. The invention provides the possibility of enzymatic and genetic manipulation for obtaining novel halogenated ansamycins through combinatorial biosynthesis.

Description

Halogen-containing AMSA microbiotic biological synthesis gene cluster
Technical field
The invention belongs to biological technical field, relate to a kind of halogen-containing AMSA microbiotic and biosynthesis gene thereof, the halogen-containing AMSA microbiotic of particularly a kind of streptomycete biological synthesis gene cluster.
Background technology
Actinomycetes are the important microbe monoids that obtains the microorganism natural product always, and traditional screening active ingredients needs by fermentation, cumbersome procedure such as separation and Extraction, purifying and structure evaluation, and not only workload is big and have blindness.
In recent years the genomic sequential analysis of the representative actinomycetes of many strains has been shown the wherein diversity of secondary metabolite biosynthesis gene.In order to make full use of the new active compound biosynthetic pathway of these potential, the genescreen that instructs based on sequence similarity becomes the Critical policies that microbial genome is prospected day by day.Except the secondary metabolite biological synthesis gene cluster that participates in the main skeleton of natural product molecule, other associated back modification gene also can be used as the index gene and determines whether bacterial strain has the ability that produces certain particular type natural product.The halo enzyme has participated in halid biosynthetic process, therefore starts with from screening halo enzyme gene, might find the biological synthesis gene cluster of new halogen-containing natural product.
From various biologies, comprise and isolate more than 4000 kind of halogenide in bacterium, fungi, all kinds of animals and plants that wherein major part is produced by marine organisms up to now.The ocean is maximum biological organic halogen source, and the halogen-containing new antibiotic such as the salinosporamide A that have been found that just derive from marine microorganism.The existing chlB4 gene recall rate of marine actinomycete that studies show that is higher than the actinomycetes in source, land, and its aminoacid sequence is obviously different with known chlB4, hints that it produces the potentiality of novel halogenated product.From being responsible for microbiotic halogenated halo enzyme gene order and catalytic mechanism research, might from marine microorganism, find novel halo enzyme, and then obtain chain with it or associated microbiotic biological synthesis gene cluster, for the research and development of such marine microorganism natural product lay the foundation.
Summary of the invention
The object of the present invention is to provide a kind of white light gray streptomycete Streptomyces albogriseolus sp.1-36 that contains halo AMSA microbiotic biological synthesis gene cluster, its culture presevation number is (CGMCC NO.3406), preservation date is on November 5th, 2009, the preservation place is the BeiJing, China, and preservation mechanism is China Committee for Culture Collection of Microorganisms common micro-organisms center (CGMCC).
Another object of the present invention is to provide a new halo AMSA microbiotic biological synthesis gene cluster, its gene order is SEQ ID NO1.
Nucleotide sequence provided by the present invention or partial nucleotide sequence, the DNA that can utilize the method for polymerase chain reaction (PCR) or comprise sequence of the present invention obtains halo AMSA microbiotic biological synthesis gene cluster as the method that probe carries out Southern hybridization from other microorganisms.
The present invention also provides the method for separating halo AMSA microbiotic biosynthesis gene from the microbial genome library.
Nucleotide sequence provided by the invention or a plurality of sequence can obtain recombination sequence and corresponding D NA molecule with the fusion of carrier sequence.
Comprise nucleotide sequence provided by the present invention or at least the cloned DNA of partial sequence can be used to from streptomycete halo AMSA antibiotic resistance gene group library the glutinous grain in more library, location.The glutinous grain in these libraries comprises the partial sequence among the present invention at least, also includes the streptomycete halo AMSA antibiotic resistance gene bunch DNA that other adjacent domain is not cloned.
Comprise sequence of the present invention or at least the clone gene of partial sequence can in foreign host, express to obtain corresponding product by appropriate expression system.These foreign host comprise streptomycete, intestinal bacteria, genus bacillus, yeast, plant and zooblast etc.
Aminoacid sequence that the present invention comprises or gene order can change in other AMSA antibiotics generated bacterium by methods such as conversion, transduction, conjugal transfers, to produce the antibiotic derivative of this kind halo AMSA.
The present invention is achieved by the following technical solutions.
Step 1, the gene clone of halo enzyme
Use the primer at halo enzymic synthesis gene design that bacterial strain DNA to be selected is carried out pcr amplification, the fragment that the positive is increased checks order, and submits to ncbi database to compare, and proves conclusively it and is halo enzyme gene fragment.Analytical results shows that the homology of halo enzyme gene asm12 is 58.9% among this halo enzyme gene and the strains A ctinosynnema pretiosum subsp.auranticum.
Step 2, bunch screening of AMSA antibiotic resistance gene
Use degenerate primer that bacterial strain DNA to be selected is carried out pcr amplification at AMSA microbiotic biosynthesizing precursor 3-amino-5-hydroxy-benzoic acid (AHBA) synthetic enzyme and polyketide synthase PKS gene design, the fragment of positive amplification is checked order, and submit to database to compare, determine to have the AMSA biological synthesis gene cluster in this strain gene group.
Step 3 is cloned complete AMSA antibiotic resistance gene bunch
Make up the Fosmid library of strain gene group; Utilize step 1 and two primers that use that genomic library is screened, determine that the external source insertion sequence carries totally 26 of AMSA microbiotic biosynthesis gene Fosmid.Checked order and restriction analysis in above-mentioned Fosmid two ends, the external source of determining 29C9,26H8, three plasmids of 5G2 is inserted segmental stack can the antibiotic biological synthesis gene cluster of complete covering bacterial strain 1-36 halo AMSA.
Step 4, the note of halo AMSA microbiotic biological synthesis gene cluster
The complete sequence of the Fosmid that step 3 is obtained carries out sequencing analysis, and splicing obtains complete halo AMSA microbiotic biological synthesis gene cluster.Utilize the online ORF forecasting tool FramePlot3.0beta that designs at high GC microorganism specially that biological synthesis gene cluster is analyzed, obtain all to read the information of frame.Sequential analysis to gene cluster is indicated, wherein contains 31 open reading frame.Their 5 PKS genes of encoding respectively, 1 acid amides synthase gene, 1 halo enzyme gene, 8 AHBA synthase genes, all the other are modified and regulatory gene after being speculated as PKS.
Carry out homology by sequence in Blast program and the ncbi database and relatively reach the conserved sequence analysis, RifA among demonstration of ORF1 gene product and the Amycolatopsis mediterranei has higher homology, consistence is 70%, similarity is 78%, infers this gene I type polyketide synthase of may encoding; The ORF2 gene product show with Amycolatopsismediterranei in RifB higher homology is arranged, consistence is 72%, similarity is 79%, infers this gene I type polyketide synthase of may encoding; The ORF3 gene product show with Amycolatopsis mediterranei in RifB higher homology is arranged, consistence is 65%, similarity is 75%, infers this gene I type polyketide synthase of may encoding; The ORF4 gene product show with Amycolatopsis mediterranei in RifD higher homology is arranged, consistence is 67%, similarity is 77%, infers this gene I type polyketide synthase of may encoding; The ORF5 gene product show with Amycolatopsis mediterranei in RifE higher homology is arranged, consistence is 70%, similarity is 78%, infers this gene I type polyketide synthase of may encoding; The ORF6 gene product show with Amycolatopsis mediterranei in RifF higher homology is arranged, consistence is 64%, similarity is 75%, infers this gene acid amides synthase of may encoding; The ORF7 gene product show with Actinosynnema pretiosum subsp.Auranticum in the halo enzyme higher homology is arranged, consistence is 61%, similarity is 71%, infers this gene halo enzyme of may encoding; The ORF8 gene product show with Amycolatopsis mediterranei in RifG higher homology is arranged, consistence is 78%, similarity is 84%, infers this gene aminodehydroquinate synthetic enzyme of may encoding; The ORF9 gene product show with Amycolatopsis mediterranei in RifH higher homology is arranged, consistence is 62%, similarity is 70%, infers this gene aminoDAHP synthetic enzyme of may encoding; The ORF10 gene product show with Amycolatopsismediterranei in Riff higher homology is arranged, consistence is 70%, similarity is 77%, infers this gene shikimate/quinate desaturase of may encoding; The ORF11 gene product show with Streptomyces sp.4353 in the AHBA synthetic enzyme higher homology is arranged, consistence is 77%, similarity is 86%, infers this gene AHBA synthetic enzyme of may encoding; The ORF12 gene product show with Amycolatopsis mediterranei in RifL higher homology is arranged, consistence is 68%, similarity is 76%, infers this gene oxydo-reductase of may encoding; The ORF13 gene product show with Amycolatopsis mediterranei in RifM higher homology is arranged, consistence is 77%, similarity is 83%, infers this gene Starch phosphorylase of may encoding; The ORF14 gene product show with Amycolatopsismediterranei in RifN higher homology is arranged, consistence is 65%, similarity is 75%, infers this gene AHBA kinases of may encoding; The ORF15 gene product show with Salinispora arenicola CNS-205 in the mono-oxygenase that relies on of FAD higher homology is arranged, consistence is 69%, similarity is 76%, infers the mono-oxygenase that may encode this gene a FAD relies on; The ORF16 gene product show with Saccharopolyspom erythraea NRRL 2338 in ferredoxin higher homology is arranged, consistence is 56%, similarity is 71%, infers this gene ferredoxin of may encoding; The ORF17 gene product show with Amycolatopsis mediterranei in RifR higher homology is arranged, consistence is 64%, similarity is 80%, infers this gene thioesterase of may encoding; The ORF18 gene product show with Amycolatopsis balhimycina in antiporter higher homology is arranged, consistence is 65%, similarity is 79%, infers this gene antiporter of may encoding; The ORF19 gene product show with Streptomyces griseus subsp.griseus NBRC 13350 in phosphoesterase higher homology is arranged, consistence is 69%, similarity is 76%, infers this gene phosphoesterase of may encoding; The ORF20 gene product show with Amycolatopsis mediterranei in modulin higher homology is arranged, consistence is 44%, similarity is 55%, infers this gene modulin of may encoding; Aminodehydroquinate dehydratase among demonstration of ORF21 gene product and the Amycolatopsis mediterranei has higher homology, consistence is 84%, similarity is 92%, infers this gene aminodehydroquinate dehydratase of may encoding; The ORF22 gene product show with Streptomycesrochei in dna primer enzyme/helicase higher homology is arranged, consistence is 67%, similarity is 76%, infers this gene dna primer enzyme/helicase of may encoding; The ORF23 gene product show with Streptomyces avermitilisMA-4680 in DNA saccharase/recombinase higher homology is arranged, consistence is 88%, similarity is 92%, infers this gene DNA saccharase/recombinase of may encoding; The ORF24 gene product show with Rhodococcus sp.RHA1 in the NADPH desaturase higher homology is arranged, consistence is 53%, similarity is 67%, infers this gene NADPH desaturase of may encoding; The pyridine two sulphur Nucleotide oxydo-reductase that FAD among demonstration of ORF25 gene product and the Salinispora arenicola CNS-205 relies on have higher homology, consistence is 59%, similarity is 70%, infers the pyridine two sulphur Nucleotide oxydo-reductase that may encode this gene FAD relies on; The ORF26 gene product show with Streptomyces griseus in transcriptional control higher homology is arranged, consistence is 83%, similarity is 93%, infers this gene transcriptional control of may encoding; The ORF27 gene product show with Frankia sp.CcI3 in the drug resistance translocator higher homology is arranged, consistence is 59%, similarity is 72%, infers this gene drug resistance translocator of may encoding; The ORF28 gene product show with Streptomyces griseus in methyltransgerase higher homology is arranged, consistence is 66%, similarity is 78%, infers this gene methyltransgerase of may encoding; The ORF29 gene product show with Streptomyces tenjimariensis in transposase higher homology is arranged, consistence is 85%, similarity is 90%, infers this gene transposase of may encoding; The ORF30 gene product show with Streptomyces tenjimariensis in transposase higher homology is arranged, consistence is 82%, similarity is 86%, infers this gene transposase of may encoding; The ORF31 gene product show with Streptomyces rochei in dna primer enzyme/helicase higher homology is arranged, consistence is 85%, similarity is 96%, infers this gene dna primer enzyme/helicase of may encoding.
The biosynthesizing of halo AMSA microbiotic relevant all genes and the albumen information of comprising provided by the present invention, can be used for production AMSA microbiotic, and help to illustrate and understand the biosynthetic molecule mechanism of AMSA microbiotic family, thereby for further utilizing the genetic engineering means transformation to provide fundamental basis and material.Gene provided by the present invention and encoded protein matter thereof also can be used for searching and develops compound or the albumen that can be used for medicine, industry, agricultural.
Description of drawings
The homology of halo enzyme gene asm12 relatively among Fig. 1 1-36 halo enzyme gene and the strains A ctinosynnema pretiosum subsp.auranticum.
Fig. 2 covers the overlapping Fosmid of bacterial strain 1-36 halo AMSA microbiotic biological synthesis gene cluster.
The external source of 29C9,26H8, three plasmids of 5G2 is inserted 81061 base pairs that segmental stack has covered 1-36 halo AMSA microbiotic biological synthesis gene cluster among the figure.
Fig. 3 halo AMSA microbiotic biological synthesis gene cluster.
The transcriptional orientation and the arrangement mode that have shown 31 open reading frame of 1-36 halo AMSA microbiotic biological synthesis gene cluster among the figure.Wherein ORF1～5 are polyketide synthase (PKS) gene, and 6 is the amido-ligase gene, and 7 is the chlB4 gene, and 8～14 and 17 is AHB A synthase gene, and 15,16 and 18～31 are regulation and control and modifying factor.
Embodiment
The invention will be further described with accompanying drawings for following example.Present embodiment has provided detailed embodiment and process being to implement under the prerequisite with the technical solution of the present invention, but protection scope of the present invention is not limited to following embodiment.The experimental technique of unreceipted actual conditions in the following example, usually according to normal condition, or the condition of advising according to manufacturer.Following examples only are illustrative for the purpose of the present invention, and non-limiting.
Embodiment:
Step 1 is extracted the DNA of marine actinomycete
With 500 μ l lysozyme soln suspension 5mg mycelium, become translucent until cell at 37 ℃ of incubations.The 2%SDS that adds 50% volume mixes the about 1min of vibration and significantly descends up to the viscosity of solution, adds the neutral phenol/chloroform of 1 times of volume then, and after the mixing vibration evenly, the centrifugal 5min of 12000rpm pipettes supernatant liquor, discards white middle layer.Repeat extracting till cannot see (or considerably less) middle layer with neutral phenol/chloroform, at last, add the 3mol/L sodium-acetate (natural pH) of 0.1 times of volume and the Virahol of 1 times of volume, turn upside down to mix and precipitate group until white cotton-shaped DNA occurring, choose DNA precipitation group with glass rod,, discard all supernatant liquors at last with 70% washing with alcohol DNA precipitation group twice, after treating the ethanol volatilization, stand-by with a certain amount of TE damping fluid dissolving DNA precipitation.
Step 2, the clone and the sequencing analysis of halo enzyme gene
Total DNA is a pcr template with alternative bacterial strain, utilizes primer HalA:5 '-TTCCCSCGSTACCASATCGGSGAG-3 '; HalB:5 '-GSGGGATSWMCCAGWACCASCC-3 ' screening contains the bacterial strain of halo enzyme gene.20 μ L amplification reaction systems are for comprising 9 μ LddH2O, 2 μ L10 * PCR Buffer, 1 μ LDMSO, primer HalA/HalB (20 μ M) each 1 μ L, 4 μ LdNTP (each2.5mM), 1 μ LTaq enzyme (1unit/ μ L), the total DNA of 1 μ L.The pcr amplification condition is: 95 ℃ of pre-sex change 3min, and 94 ℃ of sex change 1min then, 55 ℃ of annealing 1min, 72 ℃ are extended 1min totally 30 circulations, extend 10min after 72 ℃ again.The fragment of positive amplification is checked order, and submit to database to compare, prove conclusively it and be halo enzyme gene fragment.
Step 3, the clone of PKS gene and sequencing analysis
Total DNA is a pcr template with alternative bacterial strain, utilizes PKS gene test primer: PKSA:5 '-GCSATGGAYCCSCARCARCGSVT-3 '; PKSB:5 '-GTSCCSGTSCCRTGSSCYTCSAC-3 ' screening contains the bacterial strain of PKS gene.20 μ L amplification reaction systems are for comprising 9 μ LddH2O, 2 μ L10 * PCR Buffer, 1 μ LDMSO, primer PKSA/PKSB (20 μ M) each 1 μ L, 4 μ LdNTP (each 2.5mM), 1 μ LTaq enzyme (1unit/ μ L), the total DNA of 1 μ L.The pcr amplification condition is: 95 ℃ of pre-sex change 3min, and 94 ℃ of sex change 1min then, 55 ℃ of annealing 1min, 72 ℃ are extended 1min totally 30 circulations, extend 10min after 72 ℃ again.The fragment of positive amplification is checked order, and submit to database to compare, prove conclusively it and be the PKS gene fragment.
Step 4, the clone of AHBA gene and sequencing analysis
Total DNA is a pcr template with alternative bacterial strain, utilizes AHBA gene test primer: AHBAF:5 '-CCSGCCTTCACCTTCATCTCCTC-3 '; AHBAR1:5 '-TCATCAGCTTGCCGTTCTGGAAG-3 ' or AHBAR2:5 '-AYCCGGAACATSGCCATGTAGTG-3 ' screening contains the bacterial strain of AHBA gene.20 μ L amplification reaction systems are for comprising 9 μ LddH2O, 2 μ L10 * PCR Buffer, 1 μ LDMSO, primer AHBAF/AHBAR1 or AHBAR2 (20 μ M) each 1 μ L, 4 μ LdNTP (each 2.5mM), 1 μ L Taq enzyme (1unit/ μ L), the total DNA of 1 μ L.The pcr amplification condition is: 95 ℃ of pre-sex change 3min, and 94 ℃ of sex change 1min then, 55 ℃ of annealing 1min, 72 ℃ are extended 1min totally 30 circulations, extend 10min after 72 ℃ again.The fragment of positive amplification is checked order, and submit to database to compare, prove conclusively it and be the AHBA gene fragment.Step 5, the complete AMSA antibiotic resistance gene of clone bunch from the Fosmid library of strain gene group
Having extracted strain gene group Fosmid library mixing plasmid (48 clones are mixed into a pipe and extract the mixing plasmid), is template to mix plasmid, uses the Auele Specific Primer at AHBA synthase gene in the 1-36 bacterial strain and halo enzyme gene design to carry out the PCR screening.After navigating to each 96 orifice plate, carry out bacterium colony PCR again and navigate to the clone.After screening positive colony, extract plasmid, and each plasmid is carried out enzyme cut, analyze its restriction enzyme mapping, choose suitable clone and send order-checking.After order-checking was finished, according to the gene information that has obtained, the design primer continued screening and comprises the clone of its upstream and downstream gene order, and then selects suitable clone and send order-checking, covered complete AMSA antibiotic resistance gene bunch until the sequence information that obtains.
Sequence table
＜110〉State Oceanic Administration Bureau The Third Oceanography Institute
＜120〉halogen-containing AMSA microbiotic biological synthesis gene cluster
<130>invention
<160>32
<170>PatentIn?version?3.3
<210>1
<211>81061
<212>DNA
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>1
gtgcctgggc?cagaacctgg?cgcgcgtcga?actccgcgcc?ggcttctccg?ccctcctgga 60
cgcgttcccc?gacctcggcc?tcgccgtcgc?ccccgaagag?gtgccgctgc?gactccaggg 120
atccgtcttc?gcggtgaaga?gcctgcccgt?ctcctggtga?accccctttt?ccccgaaagg 180
acccgcggcc?cagtgcgcac?cgacctgatc?aagcccctgc?ccgtcgcact?tctggagaac 240
gcggtccgct?tccccgacaa?ggtcgccttc?gcggacgacc?ggcgcgcggt?cacctacggg 300
gacctggagg?cacggacacg?cagactggcc?ggacacctgg?cgcacctcgg?cgtcgagcgc 360
ggcgaccgcg?tggccctctg?cctcggcaac?accgtgtcca?ccgtggagag?ctacctggcg 420
atcgtgcgcg?ccggaggcgt?gggggtgccg?ctcaaccccg?cctccgcacc?ggccgagctg 480
gactacctgc?tcgccgacag?cggcgccgcc?ctggtcatca?ccgacaccgc?ccgggcacgg 540
aacttcaggg?gcggcccggg?ggaactgccc?gacaccgtgc?tcgtcctgac?cggcggggct 600
ccgcgggacc?tgccccaggg?gccgggcgtc?cacgcgtacg?aggaactcgc?ccgcggcgaa 660
ccgcccgtgc?ccgccaggga?cgacctcgcc?ctggacgaag?tggcctggat?gttctacacc 720
tcgggaacga?ccggccgccc?caagggcgtg?ctgtcgaccc?agcgcaactg?cctgtggtcc 780
gtcgcctcca?gctacgtacc?gatccccggc?ctgacggacc?gggaccgggt?gctgtggccg 840
ctgcccctct?tccacagcct?ctcgcacatc?gcgtgcgtgc?tgtccgtcac?cgtctccggc 900
gccaccgcac?ggctcatgga?cggcagctcc?gccgacgaca?tcatgcgggt?actgaccgag 960
gaccgcacga?ccttcctcgc?cggcgtcccc?accacctacc?accacctggt?gacggccgcc 1020
cgcgacaacg?gcttcagcgc?cccggacctg?cgcatcggcc?tggtcggcgg?tgcggtcacc 1080
ggagccggcc?tgcgccgcga?cgtcgaggag?accctcggag?taccgctggt?cgacgcctac 1140
ggcagcaccg?agacctgcgg?cgccatcacc?atgaacccgc?cggacggccc?ccgcgtggac 1200
ggctcctgcg?gcctgcccgt?acccggggtc?gacgtccgcg?tcgtcgaccc?cgccacgggc 1260
accgacgtcc?cgacgggagc?ggacggggag?gtctgggtca?gcgggccgaa?cgtcatggtc 1320
ggctaccaca?acgcccccga?cgcgaccgcc?gaggcgctgc?gcgacggctg?gttccgcacc 1380
ggggacctcg?cccggcgcga?cgacgccggc?tacttcacca?tccgaggccg?catcaaggaa 1440
ctcgtcatcc?gcggcggcga?gaacatccac?cccgaggagg?tcgaggcggt?cctgcggacc 1500
gtcgagggcg?tcgcggacgc?ggccgtcgcc?ggcgcccccc?acgacacgct?cggcgaagta 1560
cccgtcgcct?acgtggtccc?cgggcccacc?ggttacgacc?ccgccgcgct?catcgcccgc 1620
tgccgcgagc?ggctctccgc?ctacaaggtg?cccgaacgcg?tccgcgaggt?cgcgagcatt 1680
ccccgcaccc?cgtcgggcaa?gaccaaacgc?ctcctcctgg?ccgagcagcc?ggggcgactg 1740
cgctacgcgg?cgagcggaca?ccacgacgcg?ctgacacggg?tcgagtgggt?caccgcaccg 1800
gcccccgcca?ccgctccacc?ggccggcacc?cgctgggcgg?tggccggccc?ggcggccggg 1860
ctcgtgaccg?tcctggaggc?agccggcgcc?caggtccgcc?actacgccga?cctggcggcg 1920
gcgcgcgccg?cggtgaccga?cggcgacccg?gcccccgacg?tgacgctcct?ggtgccgccg 1980
gccgcgtccg?cgggcgaagc?cgtcggcggg?cgggacggcg?aatccgctgg?tggacggggc 2040
acggacgccg?tgagcgccgg?ccgcgagcgg?gcccgttggc?tggcgcggga?ggtggaagcc 2100
tggacggcac?tgccgggggc?ggcccacggc?aagctggtgc?tcctcacccc?gggcgccgtc 2160
gcggccaccg?gcacggaccc?cgcgcaggac?ctcgccgagg?cggcactgtg?gggcgccgcg 2220
cgcgccctcc?agcagacccg?gccggaaggg?ctgacggtcc?tggacgtact?ggacggtccg 2280
gacccgtccc?cggacacgtt?gtcctcggac?acgttgtcct?cggacactct?gtcggcggac 2340
accttgtcgg?cggtgctcgc?gagtgacgag?ccgcagatcg?cggtgcgttc?ggcggccctg 2400
ctcgtgcccc?gcctgacccc?gctgcccgtt?acggaccggc?cgcagaaagg?cttcgggtcg 2460
gaagccaccg?gcaccgtgtt?ggtcaccggc?gcggacacgg?aacacggcgc?cgccctggcc 2520
caccgcctgg?ccacggccca?ccgtgcgacc?tccctgctcc?tcgtcggcgc?ccccggcagc 2580
ccggacgcca?ctcccggcga?cgccctggcc?ctccccggca?cgagcgtcgt?ccgggtcacc 2640
gcggacacgg?cgcacctcgg?tccgctgcgg?gccgctctga?ccgacctgac?cgacctgggg 2700
cagccggtcc?acgcggtggt?ggacgccgcc?ggggaccccg?ccctgacgcg?gtgcctcgac 2760
cagatgaccg?cggggaacga?cctcacggcc?ttcgtcgtgg?tgacgccagg?cgccgcgggg 2820
ctgccgggca?gctcggacga?cccggcggcg?aacctcgacg?ggacgctctg?cgaagccgtc 2880
gtgcgcaacc?gccggctgcg?gaaccagccc?ggctcgttcc?tcacctggaa?cggacgtctg 2940
accgaccccg?gcgccggccc?gctgcggcag?gagttgctcg?ccgcgttcga?catcgccctg 3000
acgaccgacc?cccaggcgcc?gctggccgtc?ctgccgaccc?gcgcgaccgg?gcgcgggcgg 3060
gtgcccgccc?tcctgcgcgc?cctggtccgc?ccgcccgccc?gggacggcga?gccggactcg 3120
gcccgcacgg?tctccctgcg?cgccgaactg?tccgcgatgg?acgaccgcga?ccgacggaca 3180
cacctcgaga?acctggtccg?cacgctggcc?gccgacgtcc?tgcacctggc?ggacgccgca 3240
ctgatccccg?ccgaccgggc?cttccgcgac?ctgggcttca?cctcgctcgc?cgtcgtcgcc 3300
ctgcgcaacc?ggctgacgga?gcggaccggg?ctccggctgc?cgaccacgat?cgccttcgac 3360
cacccgaccc?cggcggacct?cgcggcgtac?ctgcggtccg?agatcctcgg?cgactcggcg 3420
ccggcagcgg?ccacgaaccc?ggccgtcgac?cccgtcgagt?ccgtcgatcc?cgctgacccg 3480
gtcgccatcg?tcggcatggc?ctgccggctg?cccggcgggg?tggcctcgcc?ggagcagttg 3540
tggaagctgg?tcgccgaagg?tgtcgacgcg?gtctcggact?tccccggcga?ccggggctgg 3600
gacctgggac?gcctcttcga?cccggaacac?cccgaccgtg?cggggacctc?ctgcacgaac 3660
cagggcggct?tcctggaggg?cgcggggttg?ttcgacgcgg?ggttcttcgg?gatctcgccg 3720
cgcgaggcgc?tggcgatgga?cccgcagcag?cggctcctcc?tggagacgtc?gtgggaggcg 3780
ctggaacggg?cgggcatcga?cccggtcacg?ctcaagggcg?ccgatgtcgg?cgtgttctcc 3840
gggctcttcg?gccaggggta?cggaacgggc?gccgtcccgc?cggaactgga?aggcttcgcg 3900
agcaccgggc?tggcgtcgag?tgtggcgtcc?ggccgggtgt?cgtacgtctt?cggcttcgag 3960
ggcccggcgg?tgtcggtgga?cacggcgtgc?tcgtcgtcgc?tggtcgcgat?gcaccttgcg 4020
gcgcaggcgc?tgcggcaggg?cgagtgctcc?atggccctgg?ccggtggtgt?ggcggtcatg 4080
gcgacccccg?acaacttcgt?ggagttctcc?cggcaacggg?cactgtccgc?cgacggccgc 4140
tgcaaggcct?tctcgtccac?ggccgacggc?acgggctggg?cggagggtgt?cggcgtcgtg 4200
gtgctggagc?gcctgtcggt?ggcgcgggag?cgcggacacc?gggtgctggc?ggtgctgcgg 4260
gggagcgcgg?tcaaccagga?cggcgcctcc?aacggcctga?cggctccgaa?cggactgtcg 4320
cagcagcggg?tgatccggcg?tgccctgtcc?agtgcggggc?tgtcggcggc?ggacgtggac 4380
gtcgtcgagg?cgcacggtac?gggtacggcg?ctgggtgacc?cgatcgaggc?gcaggcgttg 4440
ctcgccacgt?acggcaaggg?gcgtgatgcg?gggcggccgt?tgtggttggg?gtcgttgaag 4500
tcgaacgtcg?gtcatacgca?ggcggcggcg?ggtgtggccg?gtgtgatcaa?gatggtgcag 4560
gcgttgcggc?acggggtcat?gccggcgacg?ttgcatgtcg?atgcgccgac?gtcccgggtg 4620
gactggtcgg?cgggtgcggt?ggaactgctg?accgaggcgc?gggagtggcc?gcgtgaggat 4680
cgtccgcgcc?gggcgggtgt?gtcggcgttc?ggggtgagcg?ggacgaacgc?gcatctgatc 4740
ctggaggagg?cgccggagga?ggtggctgcg?ccacctgtgt?cttctgctgg?tgtggtgccg 4800
ttggtggtgt?cggcgcgtag?tgcggggtcg?ttggccggtc?aggcggggcg?tcttgccgcg 4860
ttcgtcgagg?agagcgacgg?ggtgccgctg?gcttcggtgg?ccggtgcgct?ggtcgccggg 4920
cgtgcggtgc?tgggtgagcg?tgcggtggtc?gtggccgagt?cgggcgctga?ggcgttggcg 4980
gggttgcggt?cctttgcgaa?gggcgagagc?gcgcctggtg?tggtgtccgg?cagtgcgggt 5040
tccggtgcgc?tgggcaaggt?ggtgtgggtg?tttccggggc?agggctcgca?gtgggcgggt 5100
atgggccggg?agttgatcga?cgcctcgccg?gtgttcgcgg?agcgcattgc?ggagtgtgcg 5160
gctgctttgg?agccgtggat?cgactggtct?ttggtcgagg?tgttgcgggg?tgaggtggag 5220
cccgcgttgc?tggagcgggt?ggatgtgctt?cagccggcca?gtttcgcggt?gatggtgggt 5280
ctggcggccg?tatgggcctc?tgtcggggtc?gagccggatg?cggtggtcgg?tcactcgcag 5340
ggtgagatcg?ctgcggcgtg?tgtgtcgggt?gcgttgtcgc?tggaggatgc?ggcgcgggtg 5400
gtggcgctgc?ggagtcaggc?catcgctggg?cagctcgccg?ggcgtggggg?tatggcctcg 5460
gtcgcgttga?gcgaggccga?tgccgtggcg?cgcttggagc?gttgggcgga?ccgcgttgag 5520
gtggcggctg?tcaacggccc?gtcctccgtg?gtggttgcgg?gtgatgcgga?ggcgctggac 5580
gaggcactgg?aggacctctc?ggccgacggt?gtccgggtgc?gacgggtggc?ggtcgactac 5640
gcctcgcaca?cccggcacgt?ggaggacatc?cgcgagaccc?tggtcgagac?tctcgccggg 5700
gtgaacgcgc?aggcgccgtc?gatccccttc?tactcgaccg?tgaccggcga?gtgggtggac 5760
caggcgggtg?tcctggacgg?tgcctactgg?taccggaacc?tgcggggcca?ggtcggcttc 5820
ggtcccgcgg?tgaccgacct?tgtgagccag?ggccaccgga?cgttcgtcga?ggtcagcgcg 5880
catccggtgc?tggtccagcc?ggtcaccgag?accgtctatg?ccgccggagt?cgacaccgag 5940
gccctggtca?ccggttcgct?gcgccgcgac?gacggcggcc?tgcgccgcct?gctggcctcg 6000
atggccgagc?tgttcgtgcg?cggggtcacc?gtcgactgga?ccggtgtgct?cccggccggg 6060
gcgacctcgg?cgcgtctcga?tctgccgacg?tacgccttcg?accaccagca?ctactggctc 6120
caggccaccg?atgcaggccc?cgtcgacgcc?gcctccctcg?ggctggccgg?gtcggatcat 6180
ccgctgctcg?gtgccgtcgt?gggcatgccg?aactcgggtg?gcctcgtggc?cacgtcccgg 6240
tggtcgcccg?gggcgcaccc?ctggctcgcg?gaccaggtgg?tggccgacgc?cgtcgtcgta 6300
ccgaacgccg?ctctggtcga?actggcgatc?cggctcggcg?acctggcggc?cgtccccgtc 6360
atcgacgaac?tgaccgtcga?cacgccggtc?gtgctgccgc?agggcggtga?tcgcagcatc 6420
caggtcgtcg?tgggcgagtc?cgacggggcg?cggcgaccgg?tggaggtgta?ctcccgggcc 6480
gccgacgcgc?cgctggacgc?ggagtgggta?cggcacgcgc?acggcacgct?cgtgcccgcc 6540
gacggccggg?agacgcccgc?cgttgcgggg?ccggacggcg?agtcggccga?ggtgcacctg 6600
gacggtgccg?cactgcggga?cgcggagcgg?tacggggtgc?acccggcgct?cctcgacgcc 6660
gccgtccgta?ccgtcgtccc?gagcggcatg?gtcccgtccg?tgtggtccgg?agtggctctc 6720
cacgcgtcgg?gggccaccgc?actgcacgtg?cgtcgggacg?cggcgccgga?ccaggacgca 6780
cgcctcctgc?tgaccgaccc?cgcggggcgg?cccgtcatga?cggtcgaggg?cgttcgcgcg 6840
gcgccgttct?ctcccgaacg?ggcggggatc?gccggggcgc?tgccgcatga?cgcactgttc 6900
cgtgtcgact?ggacgcccct?gtcaccggcc?accgtggacc?gcgctcccgt?cgacgtgccg 6960
gtcggagacg?gtgccgatgt?cgccgccgcc?gtcgccgggg?acggggccgc?tcccgacctc 7020
ctggtgtacg?acgtgcgagg?cggatccgcg?gcgggtgacc?cccgggagga?cgccggcgcg 7080
gccctcgccg?tgctccaggc?ctggctggcg?gcgcccgcac?cggagggggc?ccgcctggcg 7140
gtggtcacgg?gggactgcga?cgagctcggc?gccgcggccg?tgtggggact?ggtgcggtcg 7200
gcgcagtcgg?agcacccgga?ccgcgtcgtc?ctcgtggacg?tcgatgacga?tccccggccc 7260
gccctgcacg?actccgcgtc?cgcgttgacg?gccgccgtcc?tcagtggtga?accgcaactg 7320
cgggtgcgcg?gcggcgtcgc?gtccgtgccc?cgcctcgtac?gggtgcgcgg?cgcggctccc 7380
gaagccgtac?cgcccgcccg?cccgctcgac?cccgagggca?ccgtcctgat?caccggcggc 7440
accgggacgc?tcggtgcgct?cacggcgcgg?cacctggtca?ccgcgtacgg?cgtccgtcac 7500
ctggtcctgg?ccagccggag?cggcggcgcc?ccgcacctgc?gcgaggagct?gaccgagctg 7560
ggcgcgaccg?tcaccgtcac?cgcctgcgac?gtgtccgacc?gggggcaggt?cgaggcgctg 7620
ctgcgggcga?taccggccgg?gcaccccctg?accgccgtcg?tgcacaccgc?cggagtcctg 7680
gacgacggcg?tgctcaccga?gcagaccccg?caacggatcg?acaccgtact?gcggcccaag 7740
ctggacgcgg?cccgccacct?ggacgagctg?acccgggacc?tggacctcgc?cgccttcgtg 7800
ctgttctcct?cggcggcggg?catcctcggc?aacccggggc?aggccaatta?cgccgcggcc 7860
aacgcctgcc?tggacgcggt?ggcgcggcag?cggcaccgtc?tcggactgcc?ggccgtctcc 7920
ctcgcctggg?gatactggtc?gacggtcagc?gccatgaccg?agcacctgga?cgccgccgac 7980
ctgcggcgca?accggcgcat?cggcatggcc?ggtctcaccg?cggccgaggg?catggccctc 8040
cttgacgccg?ccctgagtgg?cgcggcggac?gcggacggcg?cgttgctggc?cgccaagttc 8100
gacctgtccg?tcctgcgcgc?cgcggcggcc?gacgggcccc?tgccggcgcc?gctgcggggg 8160
ctggcgcccg?cgccgcgccc?ggtggccggg?acggcgacgc?ggtcggcgcg?cggttccctg 8220
gcggagcgcc?tcgccggcct?ggacgacacc?gagcaggaag?aggcgctggt?cgacctggtg 8280
cgccggcacg?ccgccgaggt?cctcggacac?ggcaccgccg?acgcgatccg?cgccgaccgg 8340
cccttcaagg?acgccgggtt?cgactcgctg?accgcggtgg?aactgcgcaa?ccggctggtc 8400
gccgcgaccg?gcctcaccct?ctctccggcg?ctgatcttcg?actacccgaa?gcccgcgacg 8460
ctcgccgagc?acctgcgcgg?caggctcgtc?ggaggtgcgg?cgccccgtac?ggccggaacg 8520
accgaccccg?ctgcctccgt?gcccgctgtc?cccgccgttc?cggagcccgg?tgacgagccg 8580
atcgcgatcg?tcggcatggc?ctgccgcttc?cccgccggcg?tgcacagccc?ggaggacctg 8640
tggcgggtcg?tggccgacgg?cgtcgacgtc?gtcaccgagt?tccccgacga?ccggggctgg 8700
gacaccgacc?ggatcttcca?cccggacccc?gatcacgccg?gcaccaccta?cgtacgccac 8760
ggcgccttcc?tcgacgacgc?cgccgggttc?gacgccgcgt?tcttcggcat?ctcgcccaac 8820
gaggcgctgg?cgatggaccc?gcagcagcgg?ctgctgctgg?agacgtcctg?ggaggccttc 8880
gagcgcgccg?cgatcgaccc?gacgaccctc?gccgggcagg?acgtcggcgt?ctacgtcggc 8940
gtcaacagcc?acgactacag?cgtgcgcacg?caccaggcgg?ccggtgtcga?gggattccgc 9000
ctcaccggct?cctccggcgc?cgtcacctcc?ggccgcgtgg?cctaccacct?cggcaccgag 9060
ggccccgcca?tcacggtcga?caccgcctgc?tcctcctccc?tggtcgccct?gcacctggcg 9120
gcgcaggccc?tcaaccgggg?cgagtgcacg?atggcactgg?ccggcggcgt?gatggtgatg 9180
ggcaccgtcg?agacgttcgt?cgagttctcc?cggcagcgcg?gcctggcccc?cgacgggcgg 9240
tgcaaggcct?tcgcggacgg?tgcggacggc?accggctggt?cggagggcgc?ggggctgctc 9300
ctcgtggagc?ggctgtcgga?cgcccgccgc?aacggccacc?gcgtcctggc?tgtcgtccgg 9360
ggtacggccg?tgaaccagga?cggcgcctcc?aacggcctga?ccgcgccgaa?cggcccctcg 9420
cagcagcggg?tgatccgccg?ggccctggcc?gacgccgggc?tgcggacctc?ggacgtggac 9480
gccgtggagg?cgcacggcac?ggggacgacg?ctcggcgacc?cgatcgaggc?ggaggcgctg 9540
ctggcgacct?acggccagga?ccggccggcc?ggacggcccc?tgtggctggg?ctcggtgaag 9600
tcgaacatcg?ggcacacgca?ggccgcggcg?ggcgtggcgg?gcgtgatcaa?gatggtcatg 9660
gcgatgcggc?acggcgtcct?gccccgcacc?ctgcacgtgg?accggccctc?gacccacgtc 9720
gactggtcgg?cgggcgccgt?ggaactgctc?accgaggcac?gggaatggcc?gcgcgagggc 9780
cgcccgcgcc?ggaccggagt?gtcctccttc?ggcatcggcg?gcaccaacgc?ccacgtcatc 9840
ctcgaagaag?cgcccggcgt?cctcgaagaa?gcgcccggca?tccacgaggc?ggcgcccggc 9900
gtccccgcac?cggcgcccgt?gcccgggccc?gtcctcgtcc?ccgtgtcggg?gcggacaccg 9960
gccgggctgc?gcggccaggc?cgaccggctc?gcgcgcttcc?tcgacgaacg?gcccggcaca 10020
ccgctcacgg?acaccgctca?cgcgctcgcc?accacccgcg?cccgactcga?ccaccgcgcc 10080
gtcgtgctgg?cctccgaccg?gcagcagctc?cacgccgacc?tgacctccct?cgcgcagggc 10140
gggacgcccc?ccacggccgt?caccggcacc?ccggccacgg?gcaaactggc?cgtcctcttc 10200
accggacagg?gcagccagtg?ggccggcatg?ggccgcgaac?tcgccgccgg?cttcccggtc 10260
ttccggcagg?ccttcgacgc?cgcgtgcgac?gccgtcgacg?cacacctgcg?cgggcacgcg 10320
gcgctcccgc?tgcgcgaggt?cgtcctcgcc?acccccggaa?cccccggcag?cgcactgctc 10380
gaccgcacca?tgtacaccca?gggtgcgctg?ttcgccctgg?agaccgcgct?gtaccggctc 10440
ttcgcctcct?ggggcatccg?ccccgacctc?ctcgccggac?actccgtcgg?cgagatcacc 10500
gccgcccacg?tctccggggt?cctcgccctg?gaggacgcgg?ccgaactcgt?cgccgcgcgc 10560
ggccggttga?tgcaggccct?gcccgaaggc?ggtgcgatgg?tcgccgtcaa?ggccaccgag 10620
gccgacctcg?cgcccctgct?cgcccgggcg?cacggcgtgg?tctgcgtcgc?cgcggtcaac 10680
ggccccgacg?cgctggtgct?ctccggcacc?gaggacgccg?tactcgccgt?agccggcgaa 10740
ctggcacggc?gcggccacaa?gacgcacaga?ctgaccgtca?gtcacgcctt?ccactcctcg 10800
ctgatggagc?ccatgctcga?ggagttccgt?accgtcgccg?agcggctgtc?gtaccaaccc 10860
ggcgccctgc?gcgtcgtctc?caccgtcacc?ggcgaacccg?ccaccgacgg?acaactcgcc 10920
acccccggct?actgggtcga?ccaggcccgt?gccccggtcc?ggttcggcga?cgccctcgcc 10980
gcactcggcg?cgcagggcgc?cacgaccttc?ctcgaactgg?gccccggagc?cgtcctcacc 11040
gccctcgccc?tgggctcgcc?cggcgtccag?gaacagggct?gcgtggccac?cctccgcaag 11100
gacggcaccg?aacccgccga?cgtcctgacg?gcactcgcgc?acctgcacgt?gcgtggcgta 11160
cccctggact?ggccggccgt?cctcggacgc?acgacccccg?ccacggccac?cggcaccgag 11220
ctgcccacct?acgccttcca?gcaccggcgg?tactgggtcg?acaccgccgc?caccccggac 11280
gacaccggga?cccccggcac?cgccggcgcc?cggcacaccc?tgccgcccga?caccagcgtc 11340
cacccggccg?cggggagcgg?ggcaacggac?gaggccttcg?ccggacgcct?ggccgggctc 11400
ccggcccagg?aacagcaccg?cgcggtgacg?gacctggtca?aggagagcgt?cgccgtcgtg 11460
ctcggtcacc?gcgacccgga?cgcgttcgac?tggaacgcgc?agcagtcctt?caagagcctc 11520
ggcttcgact?ccctcggggc?ggtcaagctc?cgcaaccggc?tccgtgacct?caccggtgtc 11580
gaactgcccg?ccaccctggt?cttcgactac?cccacccccg?agacgctcgt?cggccacctg 11640
cgggccgaac?tgctcggcga?acagccgcag?acgccgtcca?ccccggtcgc?cggaccggcg 11700
ccggctacgg?acgagcccct?cgcgatcgtc?gccatgagca?cccgcctgcc?gggcggcgtg 11760
gacagccccg?aggcactgtg?ggagctggtg?acggagcggc?gggacgcgat?ctccggtttc 11820
ccggtggacc?gggactggga?cctcgacggc?ctgtaccacc?cggacccgga?ccaccccggt 11880
acgagctaca?cccggtccgg?gggattcctg?cacgatgccg?cgcagttcga?cgccgcactg 11940
ttcggcatct?cgccgcgcga?ggcgctggcg?atggacccgc?agcagcggct?cctcctggag 12000
acgtcgtggg?aggcgctgga?gcgggcgggc?atcgacccgc?tctccaccag?gggcagtgac 12060
atcggcgtct?tcaccgggat?cgtccaccac?gactatgtca?cccggctccg?ccaggtgccc 12120
gaggacgtac?agggctatct?catgaccggt?acggcggcga?gtgtggcgtc?gggccgggtg 12180
tcgtacgtct?tcggcttcga?gggtcccgcg?gtcaccgtgg?acacggcgtg?ctcgtcgtcg 12240
ctggtggcga?tgcacctggc?ggcgcaggcg?ctgcggcagg?gcgagtgctc?gatggcactg 12300
gccggcggcg?cgaccgtcat?ggccagcccg?gacgcgttca?tggagttctc?ccgccagcgc 12360
ggtctgtccg?ccgacggccg?ctgcaaggcc?ttctcgtcca?cggccgacgg?cacgggctgg 12420
gcggagggcg?tcggcgtcgt?ggtcctggag?cgcctgtcgg?tggcccggga?acgcgggcac 12480
aaggtcctgg?ccgtgctgcg?gggcagtgcg?gtcaaccagg?acggcgcctc?caacggtctc 12540
accgcgccca?acggtccctc?gcagcagcgg?gtgatccggc?gggcgctggc?cagtgcgggg 12600
ctctcggcgg?cggacgtgga?tgtcgtcgag?gcgcacggta?cgggcacggc?gctgggcgac 12660
ccgatcgagg?cgcaggcgtt?gctcgccacg?tacggcaagg?aacgcgacgc?cgaacggcct 12720
ctatggctcg?gttccctgaa?gtcgaacatc?gggcacgcgc?aggcggctgc?cggtgtggcc 12780
ggtgtgatca?agatggtgca?ggcgctgcgg?cacggaatca?tgccggcgac?gctccacgtg 12840
gacacgccga?ccgagcaggt?ggactggtcg?acgggtgcgg?tggagctgtt?gaccgaggcg 12900
cgggagtggc?cgcgggacgg?ccgtccacgc?cgggccggtg?tctcgtcctt?cggagccagt 12960
gggacgaacg?cgcatctgat?cctggaggag?gcgccggagg?aggtggctgc?gccacctgtg 13020
tcttctgctg?gtgtggtgcc?gttggtggtg?tcggcgcgca?gtgcggggtc?gttggccggt 13080
caggcggggc?gtcttgccgc?gttcgtcgag?gagagcgacg?gagccgctct?ggcggaggtc 13140
gccggtgcgt?tggtggccgg?gcgtgcggtg?ctgggtgagc?gtgcggtggt?ggtggccggc 13200
tcccgggacg?acgccgtggc?gggtctgcgg?gtcctcgcgc?ggggtgaggg?cggtaccaac 13260
ctggtgtccg?gcagtgcggg?ttctggtgct?ccggggaagg?tggtgtgggt?gtttccgggg 13320
cagggctcgc?agtgggcggg?tatgggccgg?gaactcctgg?acgcctcgcc?ggtgttcgcg 13380
gggcggatcg?cggagtgtgt?ggctgctttg?gagccgtgga?tcgactggtc?cttggtcgag 13440
gtgttgcggg?gtgaggcgga?gcccgcgttg?ctggagcggg?tggatgtgct?tcagccggcc 13500
agcttcgcgg?tgatggtggg?tctggcggcc?gtatgggcct?ctgtcggggt?cgagcccgat 13560
gcggtgctgg?ggcattcgca?gggtgagatc?gctgccgcgt?gcgtgtcggg?agccttgtcg 13620
ctggaggatg?cggcgcgggt?ggtggcgctg?cggagccagg?ccatccgtga?tcagctcgcc 13680
gggcgtggag?ggatggcctc?ggtcgcgctg?agcgaggccg?acgccgtggc?gcgcctggag 13740
cgttgggcgg?accgcgttga?ggtcgcggct?gtcaacggcc?cgtcctccgt?ggtcgtcgcg 13800
ggtgacgccg?gggcgctgga?cgaggcactg?gaggccctct?cggccgacgg?tgtccgcgtg 13860
cggcgggtgg?cggtggacta?cgcgtcgcac?acccggcatg?tggaggacat?ccgcgagatc 13920
ctcgccgaca?ccctcgccgg?ggtgaacgcg?caggctccgt?cgatcccctt?ctactcgacg 13980
gtgaccggcg?agtgggtgga?ccaggcgggt?gtcctggacg?gcgcctactg?gtatcgcaac 14040
ctacgcagcc?aggtcggctt?cggcccggct?gtcgcagagt?tgatcggtca?gggtcacggc 14100
gtcttcgtcg?aggtcagcgc?gcacccggtg?ctggtccagc?cgatcaccga?gaccgtctat 14160
gccgccggag?tcgacaccga?ggccctggtc?accggttcgc?tgcgccgcga?cgacggcggc 14220
ctgcgccgtc?tgctggcctc?gatggccgag?ctgttcgtgc?gcggggtcac?cgtcgactgg 14280
agcggagtgc?tcccggccgg?ggcgacctcg?gcgcggatcg?aacttccgac?gtacgccttc 14340
gaccaccagc?gctactggct?ccaggaggcg?gaaggggccg?acgaggccgc?cggtgtcgcg 14400
gagggtgcgg?actccgactt?ctgggaggcg?gtggagcgcg?ccgatctgga?cgccctcacc 14460
gagctgttgg?agacggcgtc?ggcggaggac?cggggcgcac?tgagcagtgt?cgtaccggtc 14520
ctcgccgaat?ggcgggggaa?gcggcgtgag?cgctccagtg?cggagaagct?gcgctaccac 14580
gtcacctggc?agcccctgga?acgcgaggcc?gccggcgtgc?cgggtgggca?gtggctggtc 14640
gtcgtaccgt?cggagcgtcc?ggacgacacc?gcgatcgacg?ccctcctgga?cgagctggcc 14700
ggccaagggc?tcgacatggt?cctgctggag?gtcgacgact?ccgaccggac?gcgtgcacgt 14760
ctcgtcgagc?ggctcaccgc?cgtcctcccc?ggacgcgacg?tgtccggggt?gctgtccctg 14820
ctcgcgctgg?acgagcggac?ggcgggcggc?ccgcaggatc?cgctcgccgt?gacggcctcg 14880
acgctcgccc?tgatccaggc?cctggcggac?agccgggtca?cccagcccct?gtggtgcctg 14940
accaggggcg?cggtgaacat?cggcatccac?gacacgctca?cctcgccggc?ccaggcggcg 15000
ctgtggggac?tgggccgggc?cgccgccctc?gaacgcctcg?accgctgggg?cggcctggtc 15060
gacctgcccg?ccaggacgga?cgcgcgtacg?ggccagtacc?tgctcggtgt?gctgaacggc 15120
gccggcgacg?aggatcagct?cgcggtccgg?cggtcgggcg?tctacagccg?ccgcctgctg 15180
cgcaagccgg?tgccggacgc?gacggccggt?gacggccgct?ggcagccgcg?gggcaccgtc 15240
ctggtgaccg?gcggcgccga?aggactcggc?aggcacgtcg?cggtgcggct?cgcgctctcc 15300
ggcgccgacc?ggatcgtcgt?caccaccacg?gcgcaggcac?ccgagggagc?cgtgccggac 15360
ctcgccgccg?aactggccgg?gctgggcctc?gccacggccg?tggagtcctg?cgcggacacg 15420
gaccgggaca?ccatcgcgcg?tctgctggac?gtgccggaac?agcccctgac?cgccgtcgtg 15480
cacgccgccg?acatcacccg?gaccagctcc?ctcgacgaca?ccgacggggc?cgccctcgcc 15540
gaggtgttcg?cggccaaggt?ggacaccgct?gtgtggctgg?acgaacggtt?ccaggacacg 15600
ccgctggacg?cgttcgtggt?gttctcctcg?atcgccggcg?tgtggggcgg?cggcggccag 15660
ggcccgtccg?gagcggccaa?cgccgtcctc?gacgccctgg?tcgaatggcg?ccgcgcccgg 15720
ggactgaggg?cgacggcgat?cgcctgcggc?gcgctcgacg?agatcggcgt?gggcatggac 15780
gaggccgctc?tcgcccaact?gcggcgccgc?ggtgtgctgc?ccgtggcccc?cgagctggcg 15840
gtgaccgcga?tggtccaggc?ggtgcagggc?aacgagaagt?tcgtgaccgt?ggccgacatg 15900
gactgggggg?ctttcgtccc?cgcgttcacc?tcggtccgca?ccagcccttt?gttcgccgac 15960
ctgcccgagg?cgaaggcggt?gctccaggcg?gcgcggcagg?acagcgagga?cagcgacgcc 16020
gccgcgtccc?tcgccgactc?cctgcgggcg?gtctcggaca?ccgagcagaa?ccgcctcctg 16080
ctccgcctcg?tacgcggcca?cgcctcggtc?gtcctcggcc?acggcggcgc?ggagggcatc 16140
ggaccgcgcc?aggcgttcca?ggaggtcgga?ttcgactccc?tggccgccgt?gaacctgcgc 16200
aacagcctcg?gcacggccac?cggactgcgg?ctgcccgcca?cgctgatctt?cgactacccc 16260
actccggagg?cgctggtcgg?ctatctgcgt?gccgagctgc?tccaggaggc?cgatgacggg 16320
ccggacgcgc?gcgaggacga?cctcaggcgg?gtgctggcgt?ccgtgccgtt?cgcccgcttc 16380
aaggaggccg?gtgtcctgga?cgccctcctg?ggcctcgccg?aagacggcag?tggcgtaggc 16440
ggcagtggcg?ccggaggcgc?cgccggcggc?gacgcgaacg?tggacgggcc?ggccgccggg 16500
gaggcgacgg?cggccggcac?cgaggaactg?atcgacgcaa?tggacgttgc?cggtctggtg 16560
caacgggctt?tgggcaagac?gagctgacca?ccgatggtcg?aggaatcgtg?gaggatggtt 16620
atgtccgcgc?cggacgagca?ggttgtcgac?gcactgcgcg?cctcgctgaa?ggagaacgcc 16680
aggcttcagc?aggagaacag?cgagctcgcg?gccgcggcca?cggagcccat?cgcgatcgtc 16740
tccatggcct?gccggtacgc?cggcgggatc?cgcagccccg?aggacctgtg?gcgggtggtg 16800
tccgagggcg?ccgacgtcta?cacccccttc?cccgacgacc?ggggctggga?cctggagggc 16860
ctctaccacc?ccgaccccga?caaccccggc?acgacctacg?tgcgcgaagg?tgcctttctc 16920
cacgacgccg?cccggttcga?cgccgcgttc?ttcggcatct?cgccgcgcga?ggcgttggcg 16980
atggacccgc?agcagcggca?gttgctcgaa?gtgtcctggg?aggccctcga?acgggccggc 17040
atcgaccccc?actcggtgcg?gggcagcgac?atcggcgtct?tcgccggcat?ggtgcaccag 17100
gactacgccc?ccgacctgag?cggccacgag?gacttcctca?gcctggaacg?cgcgctgggc 17160
accgcgggcg?gcgtcgcctc?cggacgcgtc?gcctacacgc?tcggactgga?gggccccgcc 17220
gtcacggtcg?acaccatgtg?ctcctcgtcg?ctggtggcga?cgcacctcgc?cgcgcaggcg 17280
ctgcgccgcg?gtgagtgctc?gatggcgctc?gtcggcggct?ccacggtcat?ggccacgccc 17340
ggcggattcg?tcggcttcgc?acggcagcgg?gccctcgcct?tcgacgggcg?ctgcaagtcg 17400
tacgccgccg?gcgccgacgg?ttcgggctgg?gcggagggcg?tgggcgtcct?gctcctggaa 17460
cggctgtcgg?tcgccgagga?gcgcggccac?cggatcctcg?cggtgctgcg?cggcagcgcc 17520
gtcaaccagg?acggcgcgtc?caacggcctc?accgcgccca?acgggcccgc?gcagcagcgc 17580
gtcatccgca?aggccctggc?cagcgccggg?ctgtcggcgg?ccgacgtgga?cgcggtggag 17640
ggccacggca?cgggcacggt?cctcggcgac?ccgatcgagg?cgcaggcgct?gatcgccacc 17700
tacggacagg?gccgcgaccc?gcggaagccg?ctgtggctcg?gctcggtcaa?gtcggtcatc 17760
gggcacacgc?aggcggcatc?cggggtggcc?ggtgtcatca?agacggtgca?ggcgctgcgg 17820
caccgggtgc?tcccggcgac?cctgcacctg?gacgcgccga?ccccccaggt?ggactggtcg 17880
gcgggcgcgg?tcgagctgct?caccgaggcc?cgggagtggc?cggaccaggg?ccgtccgcgc 17940
cgggcggggg?tgtcctcgtt?cggggccagc?ggcaccaacg?cccacctgat?cctggaggaa 18000
gcgccgccgg?aggcgaacga?gaccgcccgg?aagacgacgg?ggcccgcccg?gaacgcggcg 18060
gagagcgccc?aggacgacgc?gcgggacgcc?ggacccgccg?acgcggtgcc?gctggtggtc 18120
tcggcgggaa?ccgcgacgtc?cctggcggcc?caggcggaac?ggctggcgtc?gttcgtcgag 18180
tccggcgccg?gcggcgcgtc?gctcaccgac?gtcgccggcg?ccctggtgac?cgggcgtgcg 18240
gtgctggggg?agcgggcggt?cgtcgtggcc?agctccggcg?cggaggccct?cgccggactg 18300
cgcgccctct?cccggggcga?gagcgcgccc?ggggtcctct?ccggctcggg?gacgccgggc 18360
aaggtcgtgt?gggtgttccc?ggggcagggc?tcgcaatggg?cgggcatggg?ccgggaactc 18420
ctggacacct?caccggtgtt?cgcggcgcgg?atcgccgagt?gcgccgccgc?tctggagcgg 18480
tgggtggact?ggtccctcgt?cgatgtgctg?cggggtgagg?ccgagcccgg?agtgctggag 18540
cgggtggacg?tactccagcc?cgccagcttc?gccgtcatgg?tcggcctggc?cgccgtatgg 18600
cagtccgtcg?gcgtcgagcc?cgacgcggtg?gtcggccact?cgcagggcga?gatcgccgcg 18660
gcgtgcgtgt?ccggagcgtt?gacgctggag?gacgcggcgc?gggtcgtggc?cctgcgcagc 18720
caggccatcg?ccgaacggct?cgcgggacgc?gggggcatgg?cctcggtcgc?cctgaacgag 18780
gccgaggcgg?aatcccgtct?ggaacgctgg?gcggaccggg?tcgaggtcgc?cgccgtcaac 18840
gggccgtcct?ccgtggtgat?cgccggtgac?gccgaggcgc?tggacgaggc?gctcgacacc 18900
ctggaggacc?agggcgtacg?ggtgcggcgg?atcgccgtgg?actacgcctc?ccacacccgg 18960
cacgtcgagc?ggatccgcga?caccctcgcc?gacgccctgg?ccggcatcgg?cgcgcaggca 19020
cccgccgtcc?ccttctactc?caccgtcacg?ggcgagtggg?tggaggacgc?aggcgtcctg 19080
gacggcgcct?actggtaccg?caacctgcgc?ggccaggtcg?gcttcggccc?ggcggtggcg 19140
gaactggtcc?gccagggcca?cggcgtcttc?gtcgaggtca?gcgcccaccc?cgtcctcgtc 19200
cagccgatca?acgagaccgt?ctacgacacc?ggcacggcca?ccggcaccgg?ggacgtcacg 19260
gacgtggtgg?tgaccggttc?gctgcgccgc?caggacggcg?gaccgcgccg?gctccggacc 19320
tcgatggccg?agctgttcgt?acacggcgtg?cccgtggact?ggagcaaggt?gctgcccgac 19380
ggcgccgccg?cggcacgcgt?cgacctgccg?acgtacgcct?tcgaccacca?gcacttctgg 19440
ctcaagatgg?gcggcacggc?cacggaccag?gcgtcgctcg?gactgaccgg?cgccgaccac 19500
ccgctgctcg?gcgcggtggt?ggaactgccc?cagtccgacg?gcctggtctt?cacctcccgc 19560
ctgtccctcc?agtcccaccc?ctggctcgcc?gggcacgcga?tcggcggagt?cgtcatcgtc 19620
cccggcacgg?tctacgtcga?tctcgccgtg?cgcgccggtg?acgagttcgg?ccacggcatc 19680
ctggaggaac?tcgtcatcga?ggcgccgctc?gtgctgcccg?aacgcggcgg?cgtgcgcgtc 19740
caggtcgcgg?tgagcggacc?gggcgcgaac?ggcctgcgca?ccgtcgacgt?gtacagcctg 19800
cgggaggacg?ccgccggcga?gggcggcacc?cacgggtgga?cccggcacgc?caccggactc 19860
ctgtcggccg?cgcccgccgc?ccgggacgac?agcgacttcg?acttcgccgc?ctggccgccc 19920
cccggcgccc?agccggtcga?cgtcgagaac?ttctacgacg?acctgaccga?gcgcggctac 19980
gcctacgggc?ccgccttcca?gggcctgcgt?gccgtctggc?ggcgcggcga?cgaggtcttc 20040
gccgaggccg?ccctgcccca?ggaacagcgc?gaggacgcag?gccggttcgg?tatccacccg 20100
gcgctcctcg?acgccgccct?ccacaccaac?gccctcgccg?cgccggacga?cggccgcaag 20160
gtgctgccgt?tcgcctggaa?cggtctcgtg?ctgcacgcca?ccggcgcctc?ggcgctgcgg 20220
gtgcgggtcg?cgccgtgcgg?gccggacgcc?ctgtcgttcc?aggccgcgga?cgagaccggc 20280
ggcctcgtgc?tgaccatgga?ctccctggtg?tccctgccgg?tctccaccga?ccaactggac 20340
gccgccgcgg?cccacgacac?ccgcgacgcg?ctgttcggcg?tcgagtggac?cgggctgccc 20400
tccgtccagg?aggcggtgcc?ggttccggtg?tgggtgccgg?tcgtgtccgc?cggggatgtg 20460
gtggagctgg?cccgcggtgc?tggggccggg?gttccggctg?tggcggtgct?ggaggccgtc 20520
gcggctggtg?atggtgctgg?ggatgccgct?ctggggctga?cttcgcgggt?gctgggtgtg 20580
gtgcaggcgt?ggctgggtgc?ggcggggttg?gagaactccc?ggctggtggt?ggtgacccgg 20640
ggtgcggtgc?ctgccggtga?cggtgtggtg?agtgatccgg?cggggtcggc?ggtgtggggt 20700
ctggtgcgtg?ccgcgcaggc?ggagaatccc?gaccggatcg?tcctggtcga?cgccgacccg 20760
gccgccgctg?ccgacgacgg?acgggacgcg?gtcctggccg?ccctgacagc?cggcgacgaa 20820
ccacagctcg?ccgtgcgcgg?aacgaccctc?tccgtccccc?gcctcgcccg?cgtcaccggc 20880
caggtccccg?acagccccga?catcttccgg?ccccagggga?cggtcctggt?caccggcggc 20940
accggctccc?tgggcgcgct?ggtggcccgg?cacctcgtca?cccggtacgg?cgtacgccac 21000
ctggtcctcg?tcggccgccg?gggcccggac?gccgaaggca?tgcccgaact?cgtcgccgaa 21060
ctggccgaac?agggcgcggc?ggtctccgtc?gtggccggcg?acgtctcccg?gcgcgctgac 21120
gtcgaggcac?tgctggcctc?cgtaccggac?gagcaccccc?tgtgcggcgt?ggtccacctc 21180
gccggcgtgc?tggacgacgg?ggtgatcgcg?gccctcaccc?ccgagcgcct?cgccacggtg 21240
ttcgcgccca?aggtggacgc?cgtacgccac?ctcgacgcac?tcacccgcga?cctggacctc 21300
gacgcgttcg?tcgtgttctc?ctccgccgcc?gcgctcatgg?gatcggcggg?ccagggcaac 21360
tacgccgccg?cgaacgcctt?cctcgacggc?ctgatggcca?cgcgccgcga?ggcgggcctg 21420
cccggcctct?ccctggcctg?gggcctgtgg?gagcagagca?ccggactgac?cgcccacctc 21480
ggcgccgtcg?accaggcgcg?gatgagccgc?ggcggcgtcc?tcgcactgac?cccggccgaa 21540
ggcctgcaca?tcctcgacct?cggcctccac?atgggccagg?cactcctcgt?accgatcaaa 21600
ctcgacctgc?ggacgctgcg?cgcccaggcc?ggggacggcg?ggggagtccc?gcacctgctg 21660
cgcggcctcg?tacgcgcagg?ccgccgctcg?gcgcgggccg?ccgccggcga?cagcggcacc 21720
ctggtgcgcc?gcctcgccgg?tctgtcccag?gccgaacagg?aaagcgtcct?gctctccgtc 21780
gtacagaccg?aggcgggcgc?cgtgctcggc?ttcaccagcc?aggaactgac?gcagggcacc 21840
cgcggattca?gcgacatcgg?cttcgactcc?ctgaccgccg?tcgaactgcg?caaccggctc 21900
agcgcggcga?ccggcgtgaa?actccccgcc?acgctgatct?tcgactatcc?gacccccgtc 21960
gccctggccc?gccacctgcg?cgaggaactc?ggcgacgcgg?acaccacggt?gaccggcgtc 22020
cccgccgcgg?ccacggcggc?caccaccgcc?gaccccggcg?aacccatagc?gatcgtgggc 22080
atggcgtgcc?gcctgccggg?cggcgtgacc?agccccgacg?acctgtggca?cctggtccgg 22140
gagggccgcg?agggcgtctc?cgccttcccc?gacgacaggg?gctgggacct?ggagggcctc 22200
ttcgacaccg?accccgaccg?cgccggcacg?tcctacgcca?cccagggcgg?cttcctggag 22260
ggcgcgggcc?tcttcgacgc?cgggttcttc?gggatctcgc?cgcgtgaggc?gctggcgatg 22320
gacccgcagc?agcggctgct?cctcgaagcc?tcctgggaag?cactggagcg?cgccggtatc 22380
gacccgagca?cggcacgggg?cgacaacatc?ggcgtcttct?ccggtgtctc?catccacgac 22440
tatctcgagt?ccctgagcga?catgcccgcc?gaactcgaag?gcttcgtcac?caccgccacc 22500
gcgggaagcg?tggcctcggg?ccgggtgtcg?tacgtcttcg?gcttcgaggg?ccccgcggtc 22560
acggtggaca?cggcctgctc?gtcgtcgctg?gtcgcgatgc?acctggccgc?gcaggcactg 22620
cggcagggcg?agtgcacgat?ggcgctggcc?ggcggcgtcg?ccgtcatggg?ctcacccatc 22680
ggcgtcctcg?gcatgtcgcg?ccagcggggt?ctggccgccg?acggccgctg?caaggcgtac 22740
gcagacgacg?ccgacggcac?cgtcctgtcc?gagggcgtcg?gcctggtcgt?cctggaacgc 22800
ctgtcggtcg?cccgggaacg?cggacacaag?gtcctggccg?tcatacgcgg?cagcgcggtc 22860
aaccaggacg?gcgcctccaa?cggtctcacc?gcccccaacg?gcccctcgca?gcagcgggtg 22920
atccggcgtg?ccctgaccag?cgccgggctg?tcggcggccg?acgtggacgc?ggtggagggc 22980
cacggcacgg?gcacggtcct?cggcgacccg?atcgaggcgc?aggcgctgct?cgccacgtac 23040
ggcaaggggc?gtgatgcggg?gcggccgctg?tggttggggt?cgttgaagtc?gaacgtcggt 23100
catacgcagg?cggctgccgg?tgtggccggc?gtgatcaaga?tggtgcaggc?gctgcggcac 23160
ggaatcatgc?ccccgacact?gcacgcccag?cagcgcacga?ctcgcgtgga?ctggacggac 23220
ggcgccatcg?agttgctgac?cgaggcgcgg?gagtggccgc?gtgaggatcg?tccgcgccgg 23280
gcgggtgtct?cgtccttcgg?tatcagcggg?accaacgcgc?acctgatcct?ggaggaggcg 23340
ccggaggagg?tggctgtgcc?acctgtgtct?tctgccggtg?tggtgccgtt?ggtggtgtcg 23400
gcgcgcagtg?cggggtcgtt?ggccggtcag?gcggggcggc?ttgccgcgtt?cgtcgaggag 23460
accgacggag?ccgctctgac?ggaggtcgcc?ggtgcgctgg?tcgccgggcg?cgcggtgctg 23520
agcgagcgtg?cggtggtcgt?ggccgagtcg?ggcgctgagg?cgttggcggg?gttgcggtcc 23580
cttgcggagg?gcgagagcgc?gcctggtgtg?gtgtccggca?gtgcgagttc?cggtgcgccg 23640
gggaaggtgg?tgtgggtgtt?cccggggcag?ggctcgcagt?gggcgggtat?gggccgggaa 23700
ctcctggacg?cctcgccggt?gttcgcggag?cgtattgcgg?agtgtgcggc?ggcgttggag 23760
ccgtggatcg?actggtcttt?ggttgatgtg?ttgcggggtg?aggtggagcc?cgcggtgctg 23820
gagcgggtgg?atgtgcttca?gccggccagt?ttcgcggtga?tggtgggtct?ggctgcggtc 23880
tggtcgtcgg?tgggtgtgct?gcctgacgcg?gtggtcgggc?attcgcaggg?tgagatcgct 23940
gccgcgtgtg?tgtccggagc?cttgtcgctg?gaggacgcgg?cccgcgtagt?ggcgctgcgg 24000
agccaggcca?tcgctgggca?gctcgccggg?cggggcggta?tggcctcggt?cgccctgagc 24060
gaggccgacg?cctcggcgcg?cttggagcgt?tgggcaggcc?gcgtggaggt?ggcggccgtc 24120
aacggcccgt?cctccgtggt?cgtcgcgggt?gatgcggagg?cgttggacga?ggcgctggag 24180
gccctgtcgg?cggagggtgt?gcgggtgcgg?cgggtggcgg?tggactacgc?gtcgcacacc 24240
cggcatgtgg?aggacatccg?cgagatcctg?gccgagactc?tcgccggggt?gaacgcgcag 24300
gcgccgatgg?tgccgttcta?ctcgacggtg?accggcgagt?gggtggacca?ggcgggtgtc 24360
ctggacggcg?cctactggta?tcgcaacctg?cggggccagg?tcggtttcgg?cccggctgtc 24420
gcggagttga?tcggtcaggg?tcacggtgtc?ttcgtcgagg?tcagtgcgca?tccggtgctg 24480
gtccagccga?tcacggagat?ccttgacgac?ggtggtgacg?gcaccgatgc?cgtggtgacc 24540
ggttcgctgc?gccgcgacga?cggcggcctg?cgccggctgc?tggcctcgat?ggccgagctg 24600
ttcgtgcgcg?gtctgcccgt?ggactggacc?ggtgtactcc?cggagaccag?gactggctgg 24660
gcgcggctcg?atctgccgac?gtatgccttc?gatcaccggc?actactggct?tcagacggcg 24720
cggtcggtga?ccgatgcggc?gtcgttgggg?caggcggcgg?cggatcatcc?gctgctgggt 24780
gcggtggtga?ggttgccgca?gaccgacgga?ctggtgttca?cctcgcgtct?ctccctcaag 24840
tcgcatccct?ggctggctga?tcacgtggtc?ggcgggatgg?tgctgctccc?ggggacgggt 24900
ctggtggagc?tggcggtgcg?ggccggtgac?gaggccgggt?gtggagtgct?ggaggagttg 24960
gtgaccgagg?cgccgctggt?ggtgccggag?cacggcgggg?tgcgcgtcca?ggtcgccgtg 25020
ggcgcaccgg?gcgagaacgg?cgcacgcacc?gtcgagatct?tctcccagcg?cgaggacgct 25080
gccgacgacg?gggacacatg?gacacggcac?gccacggggc?tcctgtcggc?gtcggtgccg 25140
gctggcggcg?gggaacacga?cttcacggcg?tggccgccgc?ccggagcgca?gcccgtcgag 25200
gccggtgacc?tctacgccgg?tctggccggc?cagggttacg?agtacggtcc?cgcgttccag 25260
ggcgtgcggg?cggtgtggcg?gcgcggcgag?gaactgttcg?ccgaggtcgc?cctgcccgag 25320
gagcacggca?gggacgccga?acggttcggt?atccaccccg?cgctgctcga?cgccgccctg 25380
cacgtctccg?cgaccgatgc?cgcgacggtg?aacggtgacg?gtccgcgccg?gccgttcgac 25440
tggaagggcc?tggtcctgca?cgccgcgggt?gcctcggccc?tgcgggtgcg?actggtgccc 25500
ggtgggaccg?acaccctgac?gctggaggcg?gccgacgaga?ccggtgcccc?ggtggtgtcg 25560
gcggactcgg?tggtgatgcg?cgcgctgtcc?gccgagcagt?tggcccggcc?cgacggcatg 25620
gcgagcgcca?actcgctgtt?cctgctggac?tggacggagg?tgtcctccgt?ccaggaggcg 25680
gtgccggttc?cggtgtgggt?gccggtcgtg?tccgccgggg?atgtggtgga?gctggcccgc 25740
ggtgctgggg?ccggggttcc?ggctgtggcg?gtgctggagg?ccgtcgcggc?tggtgatggt 25800
gctggggatg?ccgctctggg?gctgacttcg?cgggtgctgg?gtgtggtgca?ggcgtggctg 25860
ggtgcggcgg?ggttggagaa?ctcccggctg?gtggtggtga?cccggggtgc?ggtgcctgcc 25920
ggtgacggtg?tggtgagtga?tccggcgggg?tcggcggtgt?ggggtctggt?gcgggccgcg 25980
caggcggaga?atcccgaccg?gatcgtcctg?gtcgacgccg?acccggccgc?cgctgccggc 26040
gacggacggg?acgcggtcct?ggccgccgtg?acggccggcg?acgaaccaca?gctcgccgtg 26100
cgcggagccg?ctcacttcgt?gccccgcctc?gcccgcgcca?ccgacgacgg?acgagtcccg 26160
gacggcactc?ccgtgttcga?cgccgagggg?accgtcctga?tcaccggagg?caccggatcg 26220
ctgggagcac?tcgcggcccg?gcacctggtc?agccggtacg?gcgtacggca?cctggtcctg 26280
gccggccgcc?ggggcccgga?cgccgagggt?gcgcaggaac?tggcggccga?gctgaccgaa 26340
ctgggggcgg?ccgtcgaggt?cgtcgcctgt?gacgtgtccg?accgcgctca?ggtcgaggcg 26400
ctcctcgcca?cggtgcccga?cgcgcacccc?ctgcgcggtg?tgatccacac?ggccggtgtg 26460
ctggacgccg?gagtcatcgg?gacgctgacc?ccggagcggc?tggcgcgggt?gttcgcgccg 26520
aaggtggacg?ccgtacggca?cctcgacgag?ctgacccgcg?ggctggacct?ggacgcgttc 26580
gtcgtctact?cgtccgtctc?gtccgtcttc?atgggcgcgg?gcagcggcag?ttacgcggcg 26640
gccaacgcct?acctggacgg?tctgatggcc?gcccggcggg?ccgagggtct?gccggggctg 26700
tcgctggcct?ggggcctgtg?ggaacagacc?agcggcatgg?cggcgaacac?cgacgacctc 26760
acccgctccc?ggatgagccg?gcgaggcggc?ctccagatga?tgaccctgac?ggagggcatg 26820
gacctcttcc?atgccgcgct?ggggtccccg?cggtcgctcc?tggtgcccgc?caagctggac 26880
ctgcggggag?tacgggcgga?cgccgcggcc?ggtgggggag?taccccacat?gctgcgcggc 26940
ctggtccgca?ccgggcggcg?gtcggcgcag?acgggcaccg?cccaggacgg?cgagctgctg 27000
cgccgcctgg?cagggctccc?caccgccgac?caggagaaga?ccctcgtcga?cctcgtacgc 27060
ggccaggccg?cgtccgtgct?cgggcacgcc?ggaccggacg?gggtccgcgc?ggacacggcg 27120
ttcaaggaca?ccgggttcga?ctcgctcacc?tccgtggaac?tgcgcaaccg?gctgcgggcg 27180
gccacaggac?tgaagctccc?cgccaccctg?gtcttcgact?acccgaaccc?gcaggccctc 27240
gcccggcacc?tgcacaccga?actgttcccg?gacggcggca?cggccggcca?ggacgtggac 27300
gaggaacgac?tgcggcgcgc?cctcgcgtcg?ctcccgctgg?cccggatccg?ggcagccggc 27360
ctgatggatg?ccctggtcaa?gctggccgcc?ctcgacgaca?gcacaccggt?caccggcgca 27420
ttcgacgacg?ccgacgagga?aatggcggtc?gccgagctgg?acgtcgacga?cctcgtgcag 27480
ctcgcgctcg?gcgacaactg?acccgcgaaa?ccgctgaagg?attggggaga?tcaagtgagt 27540
gcgtcgtatg?agaaggtcgt?cgaggcgcta?cggaaatcgg?tcgaagaggt?cggctcgctg 27600
aagaagcgga?accgccggct?cgtcgacgcc?tcccgtgagc?cggtggccgt?ggtgggcatg 27660
gcgtgcaagc?tgcccggcgg?ggtggcgggc?cccgaggacc?tgtggcgact?ggtgcgcgac 27720
ggccgcgacg?ccgtgacagg?gtttcccgag?gaccgcggct?gggacctgga?gggcctgttc 27780
gacccggacc?cggaccgtgc?gggtacgtcg?tacaccgacc?ggggcggatt?cctccacgaa 27840
gcgggtctct?tcgacgcggg?gttcttcggg?atctcgccgc?gtgaggcgct?ggcgatggac 27900
ccgcagcagc?ggctgctcct?ggagacctcc?tgggaggcct?tcgaaagcgc?cggcatcgac 27960
ccgctgtccc?tgaagggcgc?cgacgtcggc?gtcttctccg?gggtcttcgg?ccagggctac 28020
gtcgctcccg?gcgccagcgt?ggtgacaccg?gagctggagg?gcttcgcggg?cacgggcggt 28080
tccacgagtg?tggcgtcggg?ccgggtgtcg?tacgtcttcg?gcttcgaggg?gcccgcggtc 28140
acgatcgact?cggcgtgctc?gtcgtcgctg?gtcgcgatgc?acctggccgc?gcaggccctg 28200
cggcagggcg?aatgctccat?ggcactggcc?ggcggcgcga?ccgtcatggc?caaccccggg 28260
gccttcgtcg?agttctcgcg?tcagcggggc?cttgcggacg?acggccgctg?caaggcgtac 28320
gccgacggcg?cggacggcac?cggttgggcg?gagggtgtcg?gcgtcgtggt?gctggagcgc 28380
ctgtcggtgg?cgcgggagcg?cggacaccgg?gtgctggcgg?tgctgcgggg?gagcgcggtc 28440
aaccaggacg?gtgcgtccaa?cggcctgacc?gcccccaacg?gccccgccca?gcaacgggtg 28500
atccgcggag?cactcgcgaa?cgcggggctc?acacccgacg?acgtcgacgt?ggtcgagggt 28560
cacggcacgg?gcacggtcct?cggcgacccg?atcgaggcgc?aggcgttgct?cgccacgtac 28620
ggcaaggggc?gtgatgccga?acggccgttg?tggttggggt?cgttgaagtc?gaacgtcggt 28680
catacgcagg?cggcggcggg?tgtggccggt?gtgatcaaga?tggtgcaggc?gttgcggcac 28740
ggggtcatgc?cggcgacgtt?gcatgtcgat?gcgccgacgt?cccgggtgga?ctggtcggcg 28800
ggtgcggtgg?aactgctgac?cgaggcgcgg?gagtggccgc?gtgaggatcg?tccgcgccgg 28860
gcgggtgtgt?cggcgttcgg?ggtgagcggg?acgaacgcgc?atctgatcct?ggaggaggcg 28920
ccggaggagg?tggctgcgcc?acctgtgtct?tctgctggtg?tggtgccgtt?ggtggtgtcg 28980
gcgcgtagtg?cggggtcgtt?ggccggtcag?gcggggcgtc?ttgccgcgtt?cgtcgaggag 29040
agcgacgggg?tgtcgccggc?ctcggtggcg?ggtgcgctgg?tcgccgggcg?tgcggtgctg 29100
agcgagcgtg?cggtggtcgt?ggccgagtcg?ggcgcggagg?cgctgggtgg?gctgagtgcg 29160
ctggcgcggg?gtgagagcag?taccaacctg?gtgtccggta?gtgcgggttc?tggtgcgccg 29220
gggaaggtgg?tgtgggtgtt?cccggggcag?ggctcgcagt?gggcgggtat?gggccgggag 29280
ttgctggatg?cctcgccggt?gttcgcggag?cgcattgcgg?agtgcgccgc?cgctttggag 29340
ccgtggatcg?actggtctct?catcgaggtg?ttgcggggtg?aggcggagcc?cgcgttgctg 29400
gagcgggtgg?atgtgctcca?gccggccagc?ttcgcggtga?tggtgggcct?ggcggccgtg 29460
tgggcgtctg?tcggggtcga?gccggatgcg?gtgctggggc?attcgcaggg?tgagatcgcc 29520
gctgcgtgtg?tgtcgggtgc?gttgtcgctg?gaggatgcgg?cgcgggtggt?ggcgctgcgg 29580
agtcaggcca?tcgctgggca?gctcgccggg?cgtgggggta?tggcttcggt?cgccctgagc 29640
gaggccgatg?ctgttgcgcg?cctgacgcgt?tgggcggacc?gcgtggaggt?cgcggccgtc 29700
aacggcccgt?cctccgtggt?cgtcgcgggt?gatgcggagg?cgctggacga?ggcgctggag 29760
gccctgtcgg?ccgagggtgt?ccgggtgcgg?cgggtggcgg?tcgactacgc?ctcgcacacc 29820
cggcacgtgg?aggacatccg?cgagatcctc?gccgacacgc?tcgctgaggt?cgaagcccag 29880
gctccgtcga?tccccttcta?ctccacggtg?accggcgagt?gggtggacca?ggcgggtgtc 29940
ctggacggtg?cctactggta?ccgcaatctg?cgtggccagg?tcggtttcgg?cccggctgtc 30000
gcagagttga?ccgctcaggg?ccacggtgtc?ttcgtggagg?tcagcgcgca?tccggtgctg 30060
gtccagccga?tcacggagat?cctcgatgac?ggtggtgacg?gcaccgatgc?cgtggtgacc 30120
ggttcgctgc?gtcgggacga?cgggggcctg?cgtcggctgc?tggcctcgat?ggccgagttg 30180
ttcgtgcgcg?gtgtgccggt?ggactggacc?ggggttctcc?cggccggggc?gacctcggcg 30240
cgtctcgatc?tgccgacgta?cgccttcgat?caccagcact?actggctcca?ggaggtcgag 30300
tcggcgacgg?acgcggcgtc?gttggggcag?gcggcggcgg?atcatccgct?gctcggcgcg 30360
gtggtgaggt?tgccgcagac?cgacgggctg?gtgttcacct?cgcgcctctc?cctcaagtcg 30420
catccctggc?tggctgatca?cgccgtgggc?ggtgtggtca?tcctgcccgg?cacgggtctg 30480
gtggagctgg?cggtgcgggc?cggtgacgag?gcagggtgcg?gggtgctgga?ggagttggtc 30540
atcgaggcgc?cgttggtggt?gccggagcac?ggcggggtgc?gcgtccaggt?cgccgtgggc 30600
gcaccgggcg?agaacggttc?gcgcaccgtg?gagatcttct?cccagcgcga?ggacggcccc 30660
ggtgacgggg?acacatgggc?ccggcatgcc?acgggcacgc?tgtcggtcgc?cgcgtcggcg 30720
accggtgaac?ggaccgactt?caccgcatgg?ccgccggccg?gtgcggcgcc?cgtcgagatc 30780
ggtgacttct?acggcggcct?gagtgaacgc?ggctacggct?acggccccgc?gttccagggc 30840
gtgcgggcgg?tgtggaggcg?tggcgaggag?gtcttcgccg?aggtcgccct?gccggaggag 30900
caccgcaagg?acgccgaacg?gttcggcatc?catcccgcgc?tgctcgacgc?cgccctccag 30960
gccggcacca?tcgggagtgc?ggcggacgcc?gaggactccg?gggagccggt?gctcgcgttc 31020
gcgtggaacg?gcctggtcct?gcacgccgcg?ggcgcctccg?cgctgcgcgt?gcggatcgcc 31080
ccgaacggcc?cggacgcgct?gtcggtccag?gcggccgacg?aggccggtgg?ccccgtcgtg 31140
acgctggact?cgctggtgtc?ccgggcggtg?tccgcagaac?aactggacac?ggcgaccgac 31200
acgacggtcg?ccaacgcgct?gttccgcctg?gagtggagcg?aactgccgcc?gccccagggc 31260
gcggagttcc?cgccgtcctg?ggtgccggtc?tttgcccccg?gtgatgtgga?ggcactggcc 31320
gagagtgccg?gagtgccggc?ggtggcggta?ctggaggccg?tcggcggaga?cggcgacgac 31380
gccgtcctca?cgctgacctc?cggcgtcctc?gcggtcgtgc?aggcgtggct?ggccgccgac 31440
ggcctggagg?agtcgcggct?ggtggtcgcg?acccgcggcg?cggtgcccgc?cggtgacggg 31500
ggcgtggtga?ccgacccggc?cggggcggcg?gtgtggggtc?tggtgcgggc?ggcccagtcc 31560
gaggccccgg?accgcatcgt?cctcctggac?accgaccccg?ctgccgagga?cggcgtggac 31620
tcggtcctgg?actccgtgct?gggcccggtg?acggcgaccg?cggaacccca?ggtcgccgta 31680
cgcggcacga?ccctgtcggt?tccccggctc?gcccgcgtca?ccgaccgggt?cgcggacacg 31740
gccggggtgt?tcgggagcga?cgggacggtt?ctggtctcgg?gtgccggttc?gctgggtggt 31800
ctggtggccc?ggcacctggt?gtcccggcac?ggcgtacggc?acctggtcct?ggccagccgc 31860
cggggcccgg?acgccgaggg?cgtaccggaa?ctggtcgcgg?agctggccgg?gcagggggcg 31920
gccgtcgagg?tcgtcgcctg?cgacgtgtcc?gaccggaccc?aggtcgaggc?gctcctcgcc 31980
accgtgtccg?acgcgcaccc?cctgcgcggg?gtcgtccaca?cggccggggt?gttcgacgac 32040
gggctgatcg?gggcgctgac?cccggagcgg?ctggcgcggg?tgttcgcgcc?gaaggtggac 32100
gccgtacggc?acctggacgc?actgacccgc?gacctggacc?tcgacgcgtt?cgtcgtctac 32160
tcgtccgtgg?cgggcctgtc?cggcggtgcc?gggcagggca?actactccgc?cgcgaacgcc 32220
ttcctcgacg?ggctgatgtc?ccaccggcgc?gcggccggcc?tgcccggcct?ctccctcgcc 32280
tggggtctgt?gggagcagtc?cctcggcatg?gccggacacc?tcagtgccgt?cgaccaggcg 32340
cgggccagcc?gcagtggcgt?actggagata?tcggcgaccg?agggcatgga?gctgttcgat 32400
gccgctctcg?tgtccgaacg?ggcgctgctc?gtgccggtca?agctggacct?gcggaccgta 32460
cgtgccgacg?cctcggcggg?cgctgcggta?ccgcacctgc?tgcgcggact?ggtccgcacg 32520
ggccgtcagc?aggcccgggc?ggtggcaggc?tccgccggcg?caggcggcct?gctctccgac 32580
cgtctggccg?gactcgtccc?cgccgagcag?gagaccctcc?tcctcgatct?ggtgcgggcc 32640
caggccgcgg?tcgtcctcgg?ccactccgaa?cccggcggtg?tccgggcgga?catggcgttc 32700
aaggacgccg?ggttcgactc?gctcacctcg?gtggagctgc?gcaaccggct?gcgtgaggcg 32760
accggcctga?agctgccccc?gacgctcgtg?ttcgactatc?cctccccgca?ggccctcgcc 32820
cgctacctgc?gtgaggagtt?cggtgaggtg?gcggcaccgg?aggcgacggc?accggcggtc 32880
gtcgcggccg?acgcgaacga?gccggtcgcc?atcgtcggca?tggcctgccg?gctgcccggc 32940
ggggtggcct?cgccggagca?gttgtggaag?ctggtcgccg?aaggtgtcga?cgcggtctcg 33000
gacttccccg?gcgaccgggg?ctgggacctg?gagggcctct?tcgacccgga?cccggaccag 33060
gccggcaaga?gctacaccag?tcagggcggt?ttcctggagg?gtgcgggtct?cttcgacgcc 33120
gggttcttcg?ggatctcgcc?gcgcgaggcg?ctggcgatgg?acccgcagca?gcggctcctc 33180
ctggagacct?cctgggaggc?gctggaagga?gcgggcctcg?acccgacgtc?actgaagggc 33240
acggatgtcg?gcgtgttctc?cggtgtctcc?ggccagggct?acgggaccgg?cgtgctcgcg 33300
ccggaagtgg?agggcttcgc?gggcaccggg?ctggcgtcga?gtgtggcgtc?gggccgggtg 33360
tcgtacgtct?tcggcttcga?gggcccggcg?gtgtcggtgg?acacggcgtg?ctcgtcgtcg 33420
ctggtggcga?tgcacctggc?ggcgcaggcg?ctgcggcagg?gcgagtgctc?gatggccctg 33480
gccggcggtg?cgatggtgat?ggcgacaccc?gccaccttca?tggcgttctc?gcgccagcga 33540
ggcctggccg?gcgacggccg?ctgcaaggcg?ttcgccgagg?gcgcggacgg?catgggcctg 33600
tccgagggcg?tcggcgtcgt?ggtcctggag?cgcctgtcgg?tggcccggga?acgcggccac 33660
aagatcctcg?cggtgctgcg?gggcagcgcg?gtcaaccagg?acggcgcctc?caacggcctg 33720
acggctccga?acggtccctc?gcagcagcgg?gtgatccggc?gtgccctggc?gagtgccggt 33780
atcgaggccg?acggcgtgga?cgtcgtggag?gggcacggta?cgggtacggc?gctgggcgac 33840
ccgattgagg?cgcaggcgtt?gctcgccacc?tacggcaagg?accgtgaccc?ccggcagccg 33900
ctgtggctcg?gctcgctgaa?gtcgaacatc?gggcacgctc?aagccgccgc?gggtgtggcc 33960
agtgtgatca?agatggtgca?ggcgctgcgg?catggcctca?tgccgcccac?cttgcacgcg 34020
cagcggccct?ccgaccaggt?cgactggtcg?gcgggtgcgg?tggagctgct?gaccgaggcg 34080
cgggagtggc?cgcgggacgg?ccgtccgcgc?cgggccggtg?tctcgtcctt?cggtgtcagc 34140
ggcacgaacg?tgcacctgat?cctggaggag?gcgccggagg?aggatgcccc?gcaaggggtg 34200
cctgccggtg?gtgggggtgt?ggtgccgttg?gtggtgtcgg?cgcggagcgc?gggggccttg 34260
gccggtcagg?ccgggaggct?tgccgcgttc?gtcgaggaga?ccgacggggc?cgctctgacg 34320
gaggtcgccg?gtgcgttggt?cgcggggcgt?gcggtgctgg?gtgagcgtgc?ggtggtcgtg 34380
gccggctccc?gggacgacgc?cgtggcgggt?ctgcgggtcc?tcgcggaggg?tgcgaccgcg 34440
cctggtgtgg?tgtccggcag?tgcgggttcc?ggtgctccgg?ggaaggtggt?gtgggtgttt 34500
ccggggcagg?gctcgcagtg?ggcgggtatg?ggccgggaac?tcctggacgc?ttcgccggtg 34560
ttcgcggagc?gggtcgcgga?gtgtgcggct?gctttggagc?cgtggatcga?ctggtctttg 34620
gttgatgtgt?tgcggggtga?ggcggagccc?gcggtgctgg?agcgggtgga?tgtgcttcag 34680
ccggccagct?tcgcggtgat?ggtgggtctg?gctgcggtct?ggtcgtcggt?gggtgtgctg 34740
cctgacgcgg?tggtcggtca?ctcgcagggt?gagatcgctg?ccgcgtgtgt?gtccggagcc 34800
ttgtcgctgg?aggacgcggc?ccgcgtagtg?gcgctgcgga?gccaggccat?cgctgggcag 34860
ctcgccgggc?gtggcggtat?ggcttcggtc?gcgctgagcg?aggccgacgc?ctcggcttgc 34920
ttggagcgtt?gggcggaccg?ggtggaggtc?gcggctgtca?acggcccgtc?ctccgtggtc 34980
gttgcgggtg?atgcggaggc?gctggacgag?gcgctggagg?ccatgtcggc?cgagggcgtg 35040
cgggtgcggc?gggtggcggt?ggactacgcc?tcgcacaccc?ggcacgtgga?ggacatccgc 35100
gagatcctcg?ccgacacgct?cgccggggtg?aacgcacagg?caccgatggt?gcccttctac 35160
tcgaccgtga?ccggcgagtg?ggtgaaggac?gcaggggtgc?tagacggtgc?ctactggtac 35220
cggaacctgc?ggggccaggt?cggcttcggt?cccgcggtga?ccgacctgct?gagccagggc 35280
caccggacgt?tcgtggaggt?cagtgcgcat?ccggtgctgg?tccagccgat?cacggagatc 35340
ctggacgacg?gtggcgacgg?caccgatgcc?gtggtgaccg?gttcgctgcg?ccgcgacgac 35400
ggcggtctgc?gccgtttgct?ggcctcgatg?gccgagctgt?tcgtgcgtgg?tgtgcccgtg 35460
gactggaccg?gtgtgctgcc?ggagaccggg?gcgacctcgg?cgcggctcga?tctgccgacg 35520
tatgccttcg?accaccagca?ctactggctt?cagacggcgc?ggtcggtgac?cgatgcggtg 35580
tcgttggggc?aggcggcggc?ggatcatccg?ctgctcggtg?cggtggtcag?gttgccgcag 35640
accgacggac?tggtcttcac?gtcgcgtctc?tccctcaagt?cgcacccctg?gctggccgat 35700
cacgtggtcg?gcgggatggt?gctgctcccg?gggacgggtc?tggtggagct?ggcggtgcgg 35760
gccggtgacg?aggccggctg?cggggtgctg?gaggagttgg?tgaccgaggc?gccgttggtg 35820
gtgccggagc?acggcggggt?gcgcgtccag?gtcgccgtgg?gcgcaccggg?cgagaacggt 35880
tcgcgcaccg?tcgagatctt?ctcccagcgc?gaggacgctg?ccgacgacgg?ggacacatgg 35940
acccggcacg?ccaccggcat?gctggccgac?gccccccagc?cgggggcctc?aaccgccgag 36000
ttcgacttcg?ccgcgtggcc?gccggccgac?gcgcggcagg?tggagctgga?caccggcgag 36060
ctgtacgagg?gtctgctcga?gcgcggttat?gcgtacggtc?ccgtcttcca?gggcgtgcgg 36120
gcggtgtggc?ggcgcggcga?ggaactcttc?gccgaggtcg?ccctgcccga?cgagaaccgc 36180
aaggagtccg?gggacttcgg?tatccacccg?gcgctgctcg?acgccgccct?ccaggccggg 36240
acgttcgccg?tcgcggcgga?cacctcgcag?gaggaggccg?ggcagccggt?gatgccgttc 36300
gcgtggaacg?gcctggtgct?gcacgccgcg?ggcgcctccg?cgctccgggt?ccgggtcgcg 36360
cccaacggac?ccgacgccct?gtccgtcacc?gcggccgacg?cgtcgggcac?cccggtgctc 36420
acgatggact?cgctggtgat?gcgggccgtg?tccatcgagc?agttgggtgc?cacggcggcg 36480
gacgagagcc?gcgactcgct?cttcgcggtg?cggtggaccg?aactgccccc?ggcccaggag 36540
acggagcccg?cgccgccgtg?gctgccggtg?accacggccg?acgacctggc?cgccctggcc 36600
gccggcggcg?gagtcccggc?cgtggcggtc?atggaggccg?tcggaggcgc?gggcgacgat 36660
gccgtactcg?cgctgagctc?ccgggtcctg?gcgatggtgc?aggcgtggct?gggcgtgccc 36720
ggcgccgagg?agtcccgcct?cgtggtggcg?acccggggtg?ccgtgcccgc?cggtgacgac 36780
ggcgcggtga?ccgacccggc?cggggccgcg?gtgtggggcc?tggtgcgtgc?cgcccagtcc 36840
gagaatcccg?accgtgtcgt?cctcctggac?accgacccgg?gcgccgaggg?cggcgtggag 36900
cccgtgctgg?actccgtcct?cgcggcggtg?ctggccagtg?gcgagccgca?ggtcgcggtg 36960
cgcggcgggg?tgctctcggt?gccccggctc?gtccgtgcca?ccgctcaggg?catggacact 37020
aacccggtgt?tccgggaaca?gggcaccgtc?ctggtctcgg?gcggcggttc?gctgggcgcc 37080
ctggcggccc?ggcacctggt?ctcccggcac?ggcgtacgcc?acctggtcct?ggccagccgc 37140
cggggcccgg?acgccgaggg?cgtgcgggaa?ctggctgccg?agctgtccgg?gcagggggcg 37200
acggtctccg?tcgtggcctg?cgacgtgtcc?gaccgtacgc?aggtcgcgtc?cctgctcgcc 37260
cagatgccgg?cggagcaccc?actgcggggt?gtggtgcaca?cggccggtgt?gttcgacccc 37320
ggggtgatcg?gggcgctgac?cccggagcgg?ctggcgaggg?tgttcgcgcc?gaaggtggac 37380
gcggtacgac?acctcgacga?gctgacccgc?gacctggccc?tggacgcgtt?cgtcgtctac 37440
tcctccgcct?cgtccgtgtt?catgggcgcc?ggcagcggcg?gctacgcggc?ggccaacgcc 37500
tacctcgacg?ggctgatgtc?ccaccggcgc?gcggccggcc?tgcccggact?ctcgctgtcc 37560
tggggcccct?gggagcaggt?caccggcatg?gccggcaaca?tcgacgacct?caccaggacc 37620
cgtatgagcc?gacgcgaagg?acgcggaggt?gtgcaggcac?tgcggtccgc?cgagggcatg 37680
gaactcttcg?acgccgcgct?gcggtccgag?gagtcgctgc?tcgtcccggc?caggctggac 37740
ctgcgggccg?tacgggccga?cgcggcggcg?ggcggcggag?tcccgcacct?gctgcgcggt 37800
ctggtccggg?cgggccggca?gccggtccgg?acgaccggcg?gcggtggcga?ccggcggcag 37860
ctcgccgacc?ggctggtggg?actgtccgcg?gcgaagcagg?aggcactgct?cctcggcgtc 37920
gtctgcgcgc?aggccgctgt?cgtgctcggc?cacagcggac?cggagagcgt?gcgcgtggaa 37980
atggccttca?acgaagccgg?gttcgactcg?ctgacctccg?tggaactgcg?caaccggctg 38040
cgcgaggcga?ccggtctgaa?actgcccgcc?acgctggtct?tcgaccaccc?gaccccgctg 38100
gcgctcgccc?gctacctgcg?ggccgaactc?gccgtcgacg?aggcgtgccc?cgccgacgcg 38160
gtgctggccg?gactcgccgg?gctcgaagcg?gtcatcgagt?ccgcgggagc?cgacgaagaa 38220
gcccgcgacc?ggatcaccgt?acggctgctg?gagctgctgc?gcgcggccga?ggcgacgggc 38280
ggccccggcg?aggacccggt?cggcgccgac?gcggccgacg?aggatctcga?caccgccacc 38340
gacgaggaac?tgttcgccct?cgtcgaccag?ctcgactgac?gcgaccgagc?gcaccatccg 38400
tgcgcacccg?tgcgggttgt?cgcccccctg?gccgcggccc?gcacggcccc?gcacgccccc 38460
cgcacggacg?gtgcgggatc?ccacccatcg?ccatcgcaca?cattccttct?cctgggggtt 38520
gaatccagtg?gctgacgagg?cagaactccg?cgactatctc?aagcgggcca?tcgccgacgc 38580
ccgcactgcc?cgcaagcggc?tgcgcgaggt?ccaggaggag?gcacgcgagc?cgatcgccat 38640
cgtctccatg?gcctgccggt?acccgggcgg?cgtgtccacg?cccgaggagc?tgtggacgct 38700
ggtcgccgac?ggtgtcgacg?cggtctcgga?cttcccccag?gaccgcggct?gggacctgga 38760
gggcctcttc?gactccgacc?cggaccacgc?gggcacgtcg?tacgtcaccc?agggcggctt 38820
cctggagggg?gccggcctgt?tcgacgccgg?gttcttcggg?atctcgccgc?gtgaggcgct 38880
ggcgatggac?ccgcaccagc?ggctgctcct?ggagacctcc?tgggaggcgg?tcgagcgggc 38940
gggcatcgac?ccgctctccc?tcaagggcac?cgatgtcggc?gtcttctccg?ggctgtccgg 39000
acagggctac?ggtgccggcg?ccggcgtggt?gaccccggaa?accgagggct?tcgccggcac 39060
gggcgcctca?acgagtgtgg?cgtcgggccg?ggtgtcgtac?gtcctcggct?tcgagggccc 39120
ggcggtgtcc?ctcgacacgg?cctgctcctc?gtcgctggtc?gccattcacc?tggccgcgca 39180
ggcgctgcgc?cagggcgagt?gctcgatggc?cctcgcgggc?ggcgcgatgg?taatggccac 39240
ccccgggaac?ttcgtggcgt?tctcacggca?acggggtctg?gccgccgacg?gccgctgcaa 39300
ggcgttcgcc?gacggcgcgg?acggcatggg?cctggccgag?ggggtcgggg?tcgtcctcct 39360
ggaacgcctg?tcggtcgccc?gcaagcgcgg?gcacaaggtg?ctggcggtgc?tgcgggggag 39420
cgcggtcaac?caggacggcg?cgtccaacgg?tctcaccgcg?cccaacggtc?cctcgcagca 39480
gcgggtgatc?cggcgggctt?tggccagtgc?gggggtttcg?gcggcggacg?tggatgtcgt 39540
cgaggcgcac?ggtacgggta?cggcgctggg?cgacccgatc?gaggcgcagg?cgctgctcgc 39600
cacgtacggc?aaggaacgtg?acgccgagcg?gcccctgtgg?ctcggttccc?tgaagtcgaa 39660
catcgggcac?acccaggccg?ccgcgggcgt?gggcagcgtc?atcaagatgg?tgcaggcgct 39720
gcggcacggg?atcctgccgc?ccacgctgca?cgtggacgcg?cccacgaccg?aggtggactg 39780
gtcggcgggt?gcggtggagc?tgctgaccga?ggcgcgggag?tggccgcgtg?aggatcgtcc 39840
gcgccgggcc?ggtgtctcgt?ccttcggggt?gagcggtacc?aacgcgcacc?tgatcctgga 39900
ggaggcgccc?gccgaggagc?acgccccgca?gccgctgcct?gccggtggtg?ggggtgtggt 39960
gccgttggtg?gtgtcggcgc?gcagtgcggg?gtcgttggcc?ggtcaggcgg?ggaggcttgc 40020
cgcgttcgtc?gagggcgcgg?acggggtgcc?actggctgcc?gtggccggtg?cgttggtcgc 40080
ggggcgtgcg?gtgctgggtg?agcgtgcggt?ggtgctggcg?gactcggagg?cggaggcgct 40140
gggtgggctg?agtgcgctgg?cgcgtggtgc?gagcgcgcct?ggtgtggtgt?ccggcagtgc 40200
gggttctggt?gcgctgggca?aggtggtgtg?ggtgtttccg?ggtcagggct?cgcagtgggc 40260
gggtatgggc?cgggaactcc?tggacgtttc?gccggtgttc?gcggagcgta?ttgcggagtg 40320
tgcggcggct?ttggagccgt?ggatcgactg?gtctttggtt?gatgtgttgc?ggggtgaggc 40380
ggagcccgcg?ttgctggagc?gggtggatgt?gcttcagccg?gccagtttcg?cggtgatggt 40440
gggtctggct?gcggtctggt?cgtcggtggg?tgtgctgcct?gacgcggtgg?tcgggcattc 40500
gcagggtgag?atcgctgccg?cgtgtgtgtc?gggagccttg?tcgctggagg?atgcggcgcg 40560
ggtggtggcg?ctgcggagtc?aggccatcgc?tgggcagctc?gccgggcgtg?gagggatggc 40620
ctcggtggcg?ctgagcgagg?ccgacgcctc?ggcgcgcctg?acgcgttggg?ccgaccgcgt 40680
ggaggtcgcg?gctgtcaacg?gcccgtcctc?cgtggtcgtc?gcgggtgatg?cggaggcgct 40740
ggacgaggca?ctggaggccc?tgtcggccga?cggtgtccgc?gtgcggcggg?tggcggtgga 40800
ctacgcgtcg?cacacccggc?atgtggagga?catccgcgag?atcctcgccg?acacgctcgc 40860
tgaggtcgaa?gcccaggcgc?cgtcgatccc?cttctactcg?acggtgaccg?gcgagtgggt 40920
ggaggacgcg?ggcgtcctgg?acggtgccta?ctggtatcgc?aatctgcggg?gccaggtcgg 40980
tttcggcccg?gctgtcgcgg?agttgatcgg?tcaagggcac?ggtgtcttcg?tcgaggtcag 41040
tgcgcatccg?gtgctggtcc?agccgatcac?ggagatcctc?gatgacggca?ccgatgccct 41100
gatcaccggt?tcgctgcgcc?gcgacgacgg?cggcctgcgc?cggctgctgg?cctcgatggc 41160
cgagctgttc?gtgcgtggcg?tcaccgtcga?ctggaccgga?gtgctcccgg?ccggggccac 41220
ctctctggac?gtggacctgc?ccacgtacgc?cttcgaccac?cagcactact?ggctccaggc 41280
caccgatgcc?ggccccgtcg?acgcccccag?cctcggactg?gccggtaccg?atcacccgct 41340
gctcggcgcg?atggtggaac?tgccgcactc?cgaagggctg?gtgttcacgt?cccggctgtc 41400
gctcaagtcg?cacccctggc?tggccgacca?cgcgatcggc?ggcatggcgc?tgctcccggg 41460
cacgggtctg?gtggagctgg?cggtgcgggc?cggcgacgag?gccgggtgcg?gggtgctgga 41520
ggaactggtc?atcgaggcac?cgctggtggt?gccggaacac?ggcggggtgc?gcgtccaggt 41580
cgccgtgggc?gcgccgggcg?agaacggttc?gcgcggcgtc?gaggtgcact?cgcagcggga 41640
cggcgttccc?ggcgaggggg?acgcgtggac?gcggcatgcc?accggcgtcc?tgtcgtccgt 41700
ccccgccgcc?cgggacagcg?acttcgactt?cgccgcctgg?ccgccccccg?gtgcccggcg 41760
cgtcgaggtg?gacgtcgccg?gcttctacga?cgacctgcgc?gagcgcggtg?tgggctacgg 41820
accggcgttc?cagggggtgc?gggcggtgtg?gcggcgaggc?gaggagacct?tcgccgaggt 41880
cgccctgccc?gaggaactgc?accgggaagc?ggccgggttc?ggaatccacc?ccgcgctgct 41940
ggacgccgcg?ctccagacgg?gcacgttcgg?tgccgccgtc?ggcggaccgg?gggaggggga 42000
ggccggccgg?ccggtgctgg?ccttcgcgtg?gaacggtctg?gtcctgcacg?ccacgggagc 42060
ctccgcgctg?cgggtgcggg?tcgcgccgag?cggtccggac?ggcctgtcgg?tcgaggcggc 42120
cgacgagagc?ggcgccctgg?tcgtgacgat?ggactcgctg?gtgtcccggg?ccgtgtccgc 42180
cgaacaactg?gacaccgcgg?cgggttcggt?cgccaccgac?tccctgtacc?gggtcgaatg 42240
gaccgaactg?cccccggccc?gcgggccgga?gcccgtaccg?acgtgggcgg?cggtgcgcac 42300
cccggacgag?gccggggcgc?tggccgacgg?cgccggggcc?ccgcaggcgg?cggtcctgga 42360
ggccgtcggc?gggccgggcg?acgaggccgt?gctcgcgttg?acctcccggg?tcctcgcggt 42420
ggtgcagacg?tggcttgccg?cggacgggct?cgacgcgtcg?cggctcgtcg?tcgtcacccg 42480
gggcgcggtg?cccgccgacg?gcgaggacac?ggtgaccgac?ccggccgggt?cggcggtgtg 42540
gggcctggtg?cgggccgtgc?aggccgagaa?ccccgaccgt?gtcgtcctga?tggacgccgg 42600
gccggcctcc?gagggcgcgg?cgggcaccgt?gcccggggcc?gtcctcgcgg?cggtgctggc 42660
cagcggtgag?ccgcaggtcg?cggtgcgcgg?cgccgccctc?accgtgcccc?ggctggcccg 42720
tgccaccgct?caggacgtgg?acgccaaccc?ggtgttccgg?gagcagggga?ccgtcctggt 42780
ctccggcggc?ggctccctgg?gtgagctcgt?cacccggcac?ctggtcgtcc?gccacggcgt 42840
acgccacctg?gtcctggcca?gccgccgggg?cccggacgcc?gagggcgtga?acgaactggc 42900
cgccgagctg?accgggctgg?gggcgacggt?gtccgtcgtg?gcctgcgaca?tgtccgaccg 42960
cgcccaggtc?gaggctctcc?tcgcccggac?cgggcaggag?cagcccctgc?gcgcggtggt 43020
gcacaccgcc?ggtgtgttcg?aggccgggct?cgtcgagacc?ctgacgccgg?agcgcctggc 43080
gagggtgttc?gcgccgaagg?tggacgccgt?acggcacctc?gacgagctga?cccgcgacct 43140
ggccctggac?gcgttcgtcg?tctactcctc?cgcctcgtcc?gtgttcatgg?gcgccggcag 43200
cagcgggtac?gcggcggcca?acgcctacct?cgacgggctg?atgtcccgcc?ggcgcgcggc 43260
cggcctgccc?ggactctcgc?tgtcctgggg?cacgtgggcg?cacgccacca?acatgaccac 43320
ccacctcagc?accgacgacc?aggcgcggat?gagccggcgc?gccaaccgcg?atggggtcgt 43380
cgcgctcaca?ccggccgagg?gcatggaact?cttcgacgcc?gcggtcgggg?ccgcggacgc 43440
cctgcgggtg?ccggtcaagc?tcgacctgcg?gggcgtgcgg?gcctcagcgg?cggccggcgg 43500
tgcggtgccg?catctgctgc?gcggcctcgt?gcctctcacc?cgccagcagg?cgcgcgcgtc 43560
ggccgggaag?gacggggacc?tgctcggcag?gctgtccggg?ctgcccgggc?cggagcagga 43620
ggccctgctg?ctcgacctgg?tgcggactca?ggccgcggtc?gtgctcggcc?acagcggacc 43680
ggagagcgtc?aaggcggaga?ccgcgttcaa?ggacgtcggg?ttcgactcgc?tcacgtcggt 43740
ggagctgcgc?aaccggctgc?gcgaggtgac?gggcaggaaa?ctgcccgcca?cgctggtctt 43800
cgaccacccc?accccgctcg?tgctcgcccg?cttcctgcgc?ggcgaactcg?gcatcggcga 43860
cgacgtgctg?tccagggtga?ccacgaagat?agaagacgtc?gagtcgctcc?tcggtgcagt 43920
gagcctcgac?gaatccatga?ggaccagtat?cgcgctgcgc?ctccagggcc?tggtggccag 43980
gtgcaatggg?gtcgtcgagc?agacggacgg?ttccacggtc?gcggagcagc?tggaatccgc 44040
atcggccgac?gaagtcctcg?acttcatcga?cggagaactc?gggctcgtgt?gacgccggta 44100
cagggcatcc?ggcaccgcca?catctctcgt?gaggactgac?gaatggccac?ggacgaaaaa 44160
ctcctcaagt?acctcaagcg?cgtcaccacg?gaactgcaca?ccctgcgcaa?gcagggctcc 44220
tcgcacgcgg?gggagccgat?cgcgatcgtg?gggatggcgt?gcaggctgcc?gggcggtgtg 44280
acggggccgg?aggatctgtg?gcggttggtg?cgagagggcg?gggacgccgt?gtcggggttc 44340
cccgacgacc?ggggctggga?gctggacggc?ctgttcgacc?ccgacccgga?caaccctggc 44400
acctcctaca?ccgaccaggg?cggcttcctg?aagggcgcgg?gcctcttcga?cccgggcttc 44460
ttcgggatct?cgccgcgtga?ggcgctggcg?atggacccgc?agcagcggct?gctcctggag 44520
acctcctggg?aggcgctgga?gcgggcgggc?atcgacccgg?tctcgctcaa?gggcaccgac 44580
gtcggggtgt?tctccggagt?ctccagccag?ggctacggtt?ccggagccgg?cggggtcgcg 44640
cccgagctgg?agagcttcac?cggcaccggc?gtggcgtcga?gtgtggcgtc?gggccgggtg 44700
tcgtacgtct?tcggcttcga?ggggcccgcg?gtgtccgtgg?acacggcctg?ctcgtcgtcg 44760
ctggtcgcca?tccacctcgc?cgcgcaggcc?ctgcggcagg?gcgagtgctc?gctggcgctg 44820
gccggcggcg?cgatggtgat?ggcgacaccg?ggcaccttcg?tggtcttctc?ccggcagcag 44880
ggcatggccg?ccgacggccg?ctgcaaggcg?tacgcggacg?gcgcggacgg?catgggcctg 44940
gcagagggcg?cgggtgtgat?cgtcctggag?cggctgtcgg?aggcccgtga?gcgcgggcac 45000
cgggtcctcg?ccgtcatccg?gggcagcgcg?gtcaaccagg?acggcgcgtc?caacggcctg 45060
accgcgccga?acggaccgtc?gcagcagcgg?gtgatccgca?aggcactggc?cggggccgga 45120
ctcgtcgccg?cggacgtcga?cgtggtcgag?gggcacggca?ccggtacggc?gctgggtgac 45180
ccgatcgagg?cgcaggcgct?gctggccacg?tacgggcagg?ggcgggatcc?cgaacggccc 45240
ttgtggttgg?ggtcgttgaa?gtcgaacatc?gggcatacgc?aggccgccgc?cggagtgtcc 45300
agtgtgatca?agatggtcga?ggcgctgcgg?caccgcgtca?tgccgcccac?gctgcacgcc 45360
gaggagccga?cgagcgaggt?cgactggtcg?gcgggtgcgg?tcgagctgct?caccgaggcg 45420
cgggagtggc?cgagcgacgg?ccgtccgcgt?cgcgccggag?tctcctcgtt?cggcatcagc 45480
ggcacgaacg?cccacctgat?cctggaggag?gcccccgccg?ccgaggacga?gaccccggca 45540
ggggacgtga?cggcgacgcc?gggcgcggac?gagacgcccg?gcgcgcacga?gacggcgggc 45600
gcggaggcga?cggcgggcgc?ggcgggcgcg?ggcctggtgc?ccctggtcgt?gtcggcgcac 45660
ggcgaaggct?ccctcgcggg?ccaggccggg?cgcctggccg?cattcctgga?cacccggccg 45720
gacaccggcc?cggggtcgtt?gccgcgggtg?gccggggcgc?tgctgtcgga?gcgggccctg 45780
ctgcgggagc?gcgcggtggt?tctcgccgcc?acggaccagg?aggcctcggc?cggactcggg 45840
gcgctggcgc?gcggcgagca?cgcggccggg?accgtgaccg?gcagggccgc?gggagcgggc 45900
ggcccgggca?aggtcgtctg?ggtcttcccg?ggccaggggt?cccagcgcgc?cggtgcggga 45960
cgggaactct?acgaccgcta?cccggtgttc?gcccgcgccc?tggacgaggc?gtgcgagcaa 46020
ctggaggcgt?gcctcgccgg?atgggtcgac?cacccggtac?gggacgtcgt?cctgggcagg 46080
tcaccgggca?gcaccgaact?gctcaaccag?acggtgttca?cccaggcggc?cctgttcgcg 46140
gtcgagacgg?ccctgttccg?gctcgtggag?tcctggggcg?tacggccgga?cgccgtcatc 46200
ggacactcga?tcggcgaggt?gtccgccgcg?cacgtggcgg?gggtgctgtc?cctgcgcgac 46260
gcggcgcgac?tcgtcgccgc?ccggggacgg?ctgatgcagg?cactgccgcc?gggcggggcg 46320
atggtcgcgg?tcgccgccgg?cgaggcggag?gtcgacgggc?tgctcggcga?cggcgtggag 46380
atcgcggcgg?tcaacggccc?cgcggcggtg?gtcctctccg?gtgacgagga?cgccgtcctc 46440
gccgcggccg?gacgactgcg?ggaacagggc?cgcaagacca?aacgcctcgt?ggtctcccac 46500
gcgttccact?ccctgcacat?ggaaccggtg?ctggccgact?tcgccgcgga?actcaccgac 46560
gtggagtggc?gggcaccgca?gataccggtg?atctcgaacg?taaccggccg?tctcgccggg 46620
cccgacgaac?tcaccggccc?ggagtactgg?gccgggcacg?tgcgccgccc?ggtgcggttc 46680
gccgagggca?tcgccgcagc?ggtccagtac?ggcggcacgc?tcttcgtcga?gctgggcccg 46740
ggcgccgccc?tgaccggact?cgtcacggag?acggccgcct?cggcggtccc?cgacaccacc 46800
tccggccccg?gcgtcacctg?cgtggcggca?ctgcgcgacg?gccgcccgga?ggagcggacc 46860
ctgctcgcct?cgatggcgga?gctgttcgtg?cgcggcgtga?gcgtcgactg?ggcacgggtc 46920
ctgccggaca?ccggaaccgg?gacggcggtc?gtggacctgc?cgacgtacgc?cttcgaccac 46980
cagcagtact?ggctccggac?ggcgcggtcg?gtgaccgacg?cggcgtcact?gggacaggcg 47040
gcggcggacc?acccgctgct?cggcgcggtg?gtgcggctgc?cgcactccga?cgggctggtg 47100
tgcacctcgc?ggctgtccct?gaagacccac?ccctggctgg?ccgaccacac?cgtgggcggt 47160
gccgtgctcg?tccccggcac?cggcctggtg?gagctcgccg?tacgggccgg?ggacgaggcc 47220
gactgcggaa?tcctggagga?actggtcatc?gaggcgccgc?tggtggtgcc?ggagcacggc 47280
ggcgtccgcg?tccaggtcgc?cgtgggagcg?ccggaccgca?acggcgcacg?caccgtggag 47340
atccactccc?agcgcgagga?cgccccggat?gccggcgacg?cgtggacccg?gcacgccacc 47400
gccaccctcg?ccgccacccg?caccgccgca?cccgccgccc?gggacagcga?cttcgacttc 47460
accgcctggc?cgccgcccgg?cgcgcagccc?gtcgggaccg?gcgacttcta?cggcggcctg 47520
agcgaacgcg?gctacggcta?cggccccgcg?ttccagggtc?tgcgtgccgt?gtggcggcgc 47580
ggcgacgagg?tcttcgccga?ggccgccctg?cccgccgagc?accgcgagga?cgcggaccgc 47640
ttcggcatcc?acccggcgct?cctggacgcg?gccctgcacg?cggggatgtt?cggcgccgag 47700
gccgacgcgg?cggcgcacga?ccccgggcag?ccggtgctgc?cgttcgcgtg?gaacggcctg 47760
gaactgcacg?ccgcgggcgc?gcccgcgctg?cgcatccgcc?tcacctccgc?cggtcccggc 47820
gccgtcgcgc?tggaggccgc?cgacgagacc?ggcggcctcg?tcgtgaccct?ggactccctg 47880
gtgtcccggc?cggtctccgc?cgaccagctc?gcaccggtgc?cggcctcggc?ggccaccgac 47940
gcgctgttcc?gggtggactg?gaccgagatg?acgccggacc?ggtccctccc?gcccgccccg 48000
gcctgggcac?ccgtcgccac?cgccgaggac?gtggcggacc?tcgcccgcag?cggggctccc 48060
gcgatggcgg?tgctggacgc?cgtcaccacc?ggcgacgacg?gggcggacgc?cgtcctggcg 48120
ctcacctcgc?gggtgctggg?cgtggtgcag?gcgtggctgg?ccacggacgg?cctcgacgag 48180
tcccggctcg?tggtggccac?ccggggcgcc?gtgcccgccg?gcgacgaggg?cgcggtgacc 48240
gacccggccg?gggcggccgt?gtggggtctg?gtgcgggccg?cgcaggcgga?gaaccccgac 48300
cggctcgtcc?tcgtcgacgc?cgacccggcc?gccgacgacg?gcgtcgtgcc?ggtgctgggc 48360
gtggtgcggg?ccgcgggaga?accccaggcc?gccgtacgcg?gcccggcact?gagggtgccc 48420
cggctcgccc?gcgccggcgg?acccgccccg?gacacccccc?gcgtgttcga?ccccgagggg 48480
acggtactca?tcacaggcgg?caccggttcg?ctgggcggcc?tgatggcccg?gcacctggtc 48540
acccggcacg?gcgtacggca?cctggtcctg?gccggccgcc?ggggcccgga?cgccgagggt 48600
gcgcaggagc?tggcggccga?gctgaccgaa?ctgggggcgg?ccgtcgaggt?cgtcgcctgt 48660
gacgtgtccg?accgcgccca?gaccgaggcc?ctcctcggcc?ggatacccgg?cgagcacccc 48720
ctgcgcggcg?tggtgcacac?ggcgggcgtc?ctcgacgacg?gggtcatcgg?ggcgctgacc 48780
cccgaacgcc?tggggaaggt?gttcgcgccg?aaggtggacg?ccgtacggca?cctcgacgca 48840
ctgacccgcg?ggctggacct?ggacgcgttc?gtcgtgttct?cgtccgcctc?cggcgtcttc 48900
ggatcggcgg?gccagggcaa?ctacgcggcg?gccaacgcct?tcctcgacgg?cctgatggcc 48960
acgcgccgcg?aggcgggcct?gcccggcctc?tccctggcct?ggggcctgtg?ggagcaggac 49020
gccggaatga?ccgcccacct?cggcgacgcc?gaccaggccc?gcgccgggcg?cggcggcgtc 49080
ctggcgatca?ccgcgaccga?gggcaccgaa?ctgttcgacg?ccgccctcgt?ctccgggcag 49140
gcactgctcg?taccgatcaa?gatggacctg?gccgcggcgc?gggccggcgc?ggcgaccggg 49200
gcagcggtcc?cgcacctgct?gcgcggcctc?gtaccggcag?gacgcaggca?ggcgcgggcg 49260
gcggccggca?cgggcgacga?gctgccccgc?cggctgtccg?cactcaccgg?gccggaacag 49320
gacgccctcc?tcctcgacct?cgtacggacc?caggccgcgg?tcgtcctcgg?ccacagcgga 49380
cccgacagcg?tccgcgccga?caccgcgttc?aacgaagccg?ggttcgactc?gctcacctcg 49440
gtggagctgc?gcaaccggct?gcgcgaggcg?accggcctca?agctccccgc?cacgctgatc 49500
ttcgactacc?cgaacccgca?ggccctcgcg?ggcttcctgc?gcgaggagtt?cggggacacc 49560
acggcgacgt?ccggcgctcc?ggccccgtcc?acggccgccg?cggaccccga?cgaaccgatc 49620
gcggtcgtgg?gcatgtcctg?caagctgccg?ggcggtgtga?cgagccccga?cgacctgtgg 49680
cgcctggtgt?ccgagggccg?tgagggcacg?tccgccttcc?ccggggaccg?cggctgggac 49740
ctggagggcc?tgttcgacgc?cgacccggag?agcgcgggca?cctcgtacac?gagccggggt 49800
ggattcgttc?aggaagcggg?tctcttcgac?gccgggttct?tcgggatctc?gccgcgtgag 49860
gcgctggcga?tggacccgca?gcagcggctg?ctcctggaga?cctcctggga?ggccttcgaa 49920
aacgccggca?tcgacccgct?gtccctgaag?ggcaccgacg?tcggcgtctt?ctccggagtc 49980
tccagccagg?gctacggggc?cggcgtgacc?gccccggaac?tggagggctt?cgcgagcacg 50040
ggcaccgcgt?cgagcgtggc?gtcgggccgg?gtgtcgtacg?tcttcggctt?cgagggcccc 50100
gcggtcaccg?tggacacggc?ctgctcgtcg?tcgctggtcg?cgatgcacct?ggccgcgcag 50160
gccctgcggc?agggcgagtg?ctcgatggcg?ctggccggcg?gcgtgacggt?catggcgaca 50220
ccggtcagct?tcgtggagtt?ctcccgccag?cggggcctgg?ccggcgacgg?ccgctgcaag 50280
gcctacgccg?acggcgcgga?cggcaccggc?tgggccgagg?gcatcggcct?gatcgtcctg 50340
gagcgcctgt?cggtcgcccg?ggaacgcgga?cacaagatcc?tcgcggtgct?gcggggcagc 50400
gcggtcaacc?aggacggcgc?ctccaacggc?ctgaccgccc?ccaacggtcc?ctcgcagcag 50460
cgggtgatcc?ggcgggcgct?ggccagtgcg?gggctgtcgg?cggcggacgt?ggacgtcgtg 50520
gaggggcacg?gtacgggtac?ggcgctgggt?gacccgatcg?aggcgcaggc?gctgctcgcc 50580
acctacggca?aggaccgcga?cccccggcag?cccctgtggc?tcggctcgct?gaagtcgaac 50640
atcggacaca?cgcaggcggc?tgccggtgtg?gccggtgtga?tcaagatggt?ccaggcgctg 50700
cggcaccgga?tcatgccgcc?cacgctgcac?gtggacgcgc?cgtcctcgcg?ggtggactgg 50760
tcggcggggg?ccgtggagct?gctgaccgag?gcgcgggagt?ggccgcggga?cggccgtccg 50820
cgccgggccg?gtgtctcgtc?cttcggtatc?agcggtacca?acgcgcatct?gatcctggag 50880
gaggcgccgg?aggaggtggc?tgcgccacct?gtgtcttctg?ctggtgtggt?gccgttggtg 50940
gtgtcggcgc?gcagtgcggg?gtcgttggct?ggtcaggcgg?ggcggcttgc?cacgttcgtc 51000
gagggcacgg?acggggtgcc?attggcttcg?gtggccggtg?cgctggtcgc?cgggcgcgcg 51060
gtgctgagcg?agcgcgcggt?cgtcgtggcc?gactcggaca?cggaggccgt?ggccggcctg 51120
cgggcgctgg?agcgcggcga?gagcccggcc?ggcctggtca?ccggaagggt?gagcggttct 51180
ggtgcgccgg?ggaaggtggt?gtgggtgttt?ccgggtcagg?gctcgcagtg?ggcgggtatg 51240
ggccgggaac?tcctggacgc?ctcgccggtg?ttcgcggagc?ggatcgcgga?gtgtgcggct 51300
gctttggagc?cgtggatcga?ctggtctttg?gttgatgtgt?tgcggggtga?ggtggagccc 51360
gcgttgctgg?agcgggtgga?tgtgcttcag?ccggccagtt?tcgcggtgat?ggtgggtctg 51420
gctgcggtct?ggtcgtcggt?gggtgtgctg?cctgacgctg?tggtcgggca?ttcgcagggt 51480
gagatcgctg?ccgcgtgtgt?gtcgggtgcg?ttgtcgctgg?aggacgcggc?gcgggtggtg 51540
gcgctgcgga?gccaagccat?cgctgggcag?ctcgccgggc?ggggcggtat?ggcctcggtg 51600
gcgctgagcg?aggccgatgt?cgtggcgcgc?ctggagcgtt?gggcggaccg?cgtagaggtc 51660
gcggctgtca?acggcccgtc?ctccgtggtc?gtcgcgggtg?atgcggaggc?gttggacgag 51720
gcgttggagg?ccctctcggc?cgagggtgtc?cgcgtgcggc?gggtggcggt?ggattacgcg 51780
tcgcacaccc?ggcacgtgga?ggacatccgc?gagatcctcg?ccgacaccct?cgccggggtg 51840
aacgcgcagg?cgccgatggt?gccgttctac?tcgacggtga?ccggcgagtg?ggtggaggac 51900
gcaggcgtcc?tggacggcgc?ctactggtac?cgcaacctgc?ggggccaggt?cggcttcggt 51960
cccgcggtga?ccgacctgct?gagccagggc?caccggacct?tcgtggaggt?cagtgcgcac 52020
ccggtgctgg?tccagccggt?cacggagatc?ctcgacgaga?gtgacgcggc?ccccggcacg 52080
gtcgtcaccg?gttcgctgcg?tcgcgacgac?gggggcctgc?gccggctgct?ggcctcgatg 52140
gccgagctgt?tcgtgcgtgg?tgtgcccgtc?gactggaccg?gagtgctccc?ggccggggcg 52200
acctcggcgc?ggctcgaact?gccgacgtac?gccttcgacc?accagcacta?ctggctccag 52260
gccaccgatg?ccggccccgt?cgacgccacc?agcctcggac?tggccggtac?cgatcacccg 52320
ctgctcggcg?cgatggtgga?actgccgtac?tccgacgggc?tggtgttcac?ctcacggctg 52380
tcgctgaagt?cgcagccctg?gctggccgat?cacagggtcg?gcggtgtcgt?actcgtcccc 52440
ggtaccggac?tggtggagct?ggcggtgcgg?gccggtgacg?aggccggctg?cggggtgctg 52500
gaggaactgg?tcatcgaggc?gccgttggtg?gtgccggagc?acggcggggt?gcgcgtccag 52560
gtcgccgtgg?gcgcaccggg?cgagaacggc?gcacgcaccg?tggacgtcta?ctcgcggccc 52620
gaagacgccg?gctccctgcg?gagcggtgcg?gacgcctgga?cgcggcacgc?taccggcatg 52680
ctggccggca?caccccaacc?gggctcccgt?gccgccgagt?tcgacttcgc?cgcctggccg 52740
cccccggggg?cgcagccggt?ggacgtcgcc?ggtgggtacg?gtctgctcac?cgaggtgggt 52800
tacgggtacg?gcccggcgtt?ccagggcgtg?cgcgccctgt?ggcggcgagg?cgacgagatc 52860
ttcgccgagg?tcgccctgcc?ggaggagcac?cgcgcggacg?ccgcccggtt?cggtatccac 52920
cccgcgctgc?tcgacgccgc?tctgcactcg?ccgctgctcc?agatcgccgg?ggcggacgcg 52980
ggcgacggtg?cggccgaggc?ggcgccgggc?gggcccgagc?tgcggctgcc?gttcgcgtgg 53040
aacggcctgg?tgctgcacgc?cgcgggagcc?tcggtcctgc?gggtgcgcgt?cgcgcggtcc 53100
gagcacgacg?cgctgtcgct?ggccgcggcg?gacgagaccg?gcgcgccggt?cgtgacgatg 53160
gactccctgg?tgtcccgggt?ggtctccgcc?gaccagctcg?agacggccgc?gggcaccacc 53220
cgggccgact?cgctgttccg?ggtggagtgg?accgagctgc?tgccgctcct?gggcacggag 53280
accgtgccgt?cctggtcgcc?ggtgtccacc?gcggaagagg?tggccaccct?ggccgacgac 53340
gtggaatcgg?gcgccccggc?acctgccctg?gcggtcctcg?aagccatcgg?cggtgagggt 53400
gccgacgcgg?cgctggacct?ggccacccgg?gtgctggagg?ccgtgcagtg?ctggctggac 53460
gggcccggcc?tggaagagac?gcggctggcc?gtggtgaccc?ggggcgcggt?gcccgccggc 53520
ggcgaggaga?cggtgaccga?tccggcgggg?tcggcggtgt?ggggcctcgt?gcgcgccgcg 53580
caggccgaga?acccggaccg?catcctcctc?atcgacacgg?acccggccgg?cacggctccc 53640
gtcgaggcgg?cggtgaccgc?gctgggcgtg?gcgctggccg?gcggcgagcc?gcaggtcgcg 53700
gtgcgcggcg?gggtgctctc?ggtgccccgg?ctcgtccggg?ccggtgtcca?gggcaccgac 53760
ccggacacgg?cgttcggacc?ggacgggacg?gttctggtct?cgggtgccgg?ttcgctgggt 53820
ggtctggtgg?cccggcatct?ggtgtcccgg?cacggcgtac?ggcacctggt?cctggccagc 53880
cgccggggcc?cggacgccga?gggcgtaccg?gaactggtcg?cggagctggc?cgggcagggg 53940
gcggccgtcg?aggtcgtcgc?ctgtgacgtg?tccgaccgcg?ctcaggtcga?ggcgctcctc 54000
gccaccgtgt?ccgacgcgca?tcccctgcgc?ggggtcgtcc?acaccgcggg?cgtgaccgac 54060
gacggtgtca?tcggggcgct?gaccccggag?cggctggcgc?gggtgttcgc?gccgaaggtg 54120
gacgccgtac?ggcacctcga?cgagctgacc?cgcgggctgg?acctggacgc?gttcgtcgtc 54180
tactcgtccg?tctcggcggt?gttcatgggc?gcgggcagcg?gcagttacgc?ggcggccaac 54240
gcctatctgg?acggtctgat?ggccgcccgg?cggggcgcgg?gtctgccggg?gctgtcgctg 54300
gcctggggcc?tgtgggagca?gaccagcggc?atggcggcga?acaccgacga?cctcacccgc 54360
tcccggatga?accggcgggg?cggcctccag?gcgatcaccc?cggccgaagg?catggaactg 54420
ttcgacgccg?ccgtgcggtc?tgggcaggcg?cagctcgtgc?ccgccaaact?ggacctggcg 54480
tcgctgcgca?cccgggccac?ggacggcggg?ggagtcccgc?acctgctgcg?cggcctggtc 54540
cgcgccggcc?ggcagacggc?ccacacggcg?agcgtcggcg?accagggcaa?ggccctgtcc 54600
gagcggctgg?ccgcactccc?ggccgccgag?caggccgagc?tgctgctcga?cgtggtccgc 54660
gaccaggtgg?ccgcggtgct?ggggcacagc?gccacgttcc?gcatcgacgc?ggaccaaggg 54720
ctgttcgagg?tcggcttcga?ctccctcacc?tccatcgaac?tgcgcaaccg?gctccgtgac 54780
ctcaccgagc?gcaaactccc?gccccacctg?gtcttcgacc?atccgacggc?agcgtcgctc 54840
gccgcttacc?tgcaccggct?cgtgtgcggc?gaacaggcgg?cacttgcggt?cgcgggcccc 54900
gtagcggtct?ccgtgtgacg?cggcgaaccc?acccccagag?aaggtgacgc?aagtgttcga 54960
cgtggacagg?tacctggcgc?ggatcggctg?tgccggagag?accggtgtgg?acatcgcgac 55020
cctgcgcaag?ctgcaccgca?accacctcat?ggcgatcccg?tacaacgggg?ccacccagga 55080
cttcgcggac?ggggtgcggc?tcgtcgacct?cgacgaggac?gccacgttcg?agacgtgcgt 55140
catccagggg?cggggcggca?cgtgcttcca?gctcaaccgg?ctgttctccc?ggctgctgac 55200
ggaactcggc?cacgacgtca?ccctgctggc?ggccagcacc?gcggagggac?gggaggcgtc 55260
cgggctcgac?gtggagcaca?tgttcaaccg?cgtcgccctg?gacggcgccg?actggctcgt 55320
ggacgtcggc?taccccggcc?cctcctacgt?ggagccgctg?ctggtcaccg?acgcggtgca 55380
gagccagtac?ggctgccagt?accgcctggt?cgaccgcgga?tccaggaccg?ctctacagcg 55440
ccggggaagg?atcacgcggt?ggagcgtcgt?ctacaccttc?acgccgcagg?cccggcagtg 55500
gagcgactgg?aaggaaatgg?aggagttcct?cgtccgggag?atcgccgcgg?acacaggacc 55560
gcgggacggc?cggaacatcc?tgtgcggccg?cacgctcgac?aacggtcagg?ccgtcctgaa 55620
aggacgccgc?tacctgacgg?tccgggacgg?ccgcgaggag?atccgcacga?tcacggacga 55680
cgacgagcac?cagcggctgg?tctcccacct?gctgtccgac?gcgttcggct?gagccgaacc 55740
gcatgccgtc?accgagcact?cccgcacccc?gcacccagca?cccagcgctg?cggacactca 55800
cgttcgcacc?ggaccgcgca?ccagaaaggg?aagaagatgg?cgaaggaaac?agccgatgtg 55860
gtcgtgatcg?gcggagggcc?ggccggttcg?gtctgcgcct?acgtgctcgc?caaacagggg 55920
cactccgtgg?tgctcctgga?gaaggagctg?agttcacgct?tccacatcgg?cgagtccctg 55980
ctgccgtaca?tgatgggcct?gttcgagcgg?atcggactgc?gggagacggt?cgcggcccag 56040
ggctacgtgc?ccaagttcgg?cggcgagttc?atcgacccga?cggagaagaa?gttcttcgag 56100
ggcgtcttcc?gcgctgactt?caccaagcag?ggtgtgggcc?ggcacgacaa?cgccttccag 56160
gtcgagcgcg?ccaagttcga?ccggatgctc?gccgagcagg?ccgaggccgc?cggcgcgcgc 56220
gtcctgttcg?gtgcgaacgt?caacgagctg?ctcatggacg?gtgaccggat?ggtcggcgtc 56280
cgctacgagc?gcgacggcga?gagccacgag?gtgagctccg?cctacgtggt?cgacgccagc 56340
ggccgttccg?ggcggatcgc?caaccgcttc?gggctgcgca?agaccctcga?gaagctccgc 56400
atggtcgccg?tgttccggca?ctacagcggc?ctcgacgagc?gccacaaccc?cggtgtcgag 56460
ggtgacatcc?aggtcggcgc?ccacgacgac?ggctgggtct?gggcgatccc?gctgaccaag 56520
gacaccatca?gcgtcggcac?ggtcatgccg?cgcgacgtgc?tgcgcggggc?gacgacgcag 56580
gagcggttcg?acgagcacct?ggcccgcgtc?ccccggatcg?tcgcccgcct?gaccggcacc 56640
cgcccctcga?tggacctcaa?ggtcgagacc?gactactgct?accacaccga?cacggtcacc 56700
ggccccggct?ggctcatggt?cggcgacgcc?ggctgcttcg?gcgacccgat?gttctccggc 56760
ggcgtcctcg?tggcgacggc?caccgccgtc?cgcgccgccg?agacgctcgg?cgaggtgctg 56820
gccgacccgt?cggccgagga?ccgcctgctg?gagaggtact?ccaactactt?caagaccggg 56880
tacgacacct?acatccggct?catccactcc?tactacgacg?gcgaattggt?cgccatggcc 56940
gccgacgccg?cccgctccac?cgaccgcgaa?accctggaga?agtacctcat?gcggctgatc 57000
gggggcgatt?tctggagcga?gcacaactcg?gtggcccagg?agatgcggcg?ccgcaaggag 57060
tgggacacct?tcgagccgtt?ccagcgggtc?tacggctgcc?cgtcctatcc?gcacctggac 57120
gaactcgacc?gcaaggagcg?gtccgaggca?cgcgtccgcc?gggtgacggc?gggccggtag 57180
ggaacggtca?tggcatccat?tccgctgcgc?ctgaaagacc?attcctacga?cgtcctcatc 57240
ggtcccgggg?tgcgtacgtc?gctcgccgag?gtcgtcgggc?ggctgggcgc?cggacgggcg 57300
gtcgtcgtgt?cggcccgccc?gcgggaatgg?gtgcccgaca?ccggtgtgga?caccctgttc 57360
cttccggcac?gcgacgggga?acgggacaag?acgctcggca?cggtggagca?gctgtgcggc 57420
gagttcgtac?gcttcggtct?cacccggtcc?gacgtcgtcg?tctcgtgcgg?cggcggaacc 57480
accaccgacg?tggtcggact?cgccgccgcc?ctctaccacc?gcggtgtcgc?ggtcgtccac 57540
ctgcccacca?cgctgctggc?ccaggtggac?gcgagcgtcg?gcgggaagac?cgcggtcaac 57600
ctgcccgccg?ggaagaacct?ggtcggcgcg?tactggcagc?cgagcgcggt?cctgtgcgac 57660
acggactacc?tgtccaccct?gccgcggcgg?gaactgctca?acggctacgg?cgagatcgcc 57720
cgctgccact?tcatcggcgc?gccggacctg?cgcgcgctgc?cgcccgccga?gcagatcgcc 57780
gcgagcgtgg?ccctcaaggc?ccgcgtcgtg?gaggccgacg?agcgggacgc?cggaccgcgg 57840
cacatcctca?actacggcca?cacgctgggc?cacgcgctgg?agctggcgac?cgggttcgcc 57900
ctgcgccacg?gcgaggcggt?ggccgtcggc?acggtcttcg?cgggacgcct?cgccggcgcc 57960
ctcggccgga?tcggcgggga?acgggtggcc?gaacaccacg?acgtcgtccg?cgcctacggg 58020
ctgcccgccg?cgctgcccgc?cgagaccgaa?cccgcggaac?tggtacggct?gatgcggcac 58080
gacaagaagg?cgctcagcgg?actcacgttc?gtcctcgacg?gtccgaaggg?tgtggaactc 58140
gtgtacgacg?taccgcccga?gctggtcacg?cgcgtcctcg?accggatgcc?cagggcgccc 58200
ctggccgaac?tcgtcggcga?cgccgagccg?gccgccacac?cggccacggc?acgctcatga 58260
ggcagccgac?ccggtggccg?cccggcaccg?cggcgcccac?ccccgccgag?accccggcca 58320
cccccatcgg?cgacaccgcc?ctcccgggcg?ccccggcccc?cacccacgac?ccggccgccc 58380
tcatcggcag?cccgctcggc?ggcaggcttg?ccgatgccct?ggcgcggccc?gccgcacagc 58440
agccgcactg?gcccgacccg?gcccgcgccg?agcggatcac?cgccctgctc?ggccgcgccg 58500
cgcccgtcgt?cacgccggcc?gagacggccc?gtctgcgcgc?ggaactcgcc?gcggtcgccc 58560
ggggcgaggc?gttcctcctc?caggccggcg?actgcgccga?ggccttcgcc?gagaacacgc 58620
aggcccacca?gcgggccaac?ctgagcacgc?tggcggagat?ggccgacgtg?ctcacccgcc 58680
gcaccggact?gcccgtcgtc?aagatcgccc?gcatggccgg?ccagtacgcc?aagccccgct 58740
cccgggccgt?cgacgcccaa?gggctgcccg?cctaccgcgg?cgacatggtc?aactccgccg 58800
agcccaccac?ggccgcccgc?acccccgacc?ccggccggat?gctgcgcgtc?cacgccgagg 58860
ccgcccgcac?gatggcgctg?gtccgccgga?ccggccgggg?cgacgtctac?gtcagccacg 58920
aggcgctgct?cctcgactac?gagcggtcct?cgctgcgcgc?cgacaccgac?ggccccgaac 58980
cccgcctgac?cagcgggctc?ggccacttcc?tgtggatcgg?cgaacgcacc?cgcgagcccg 59040
acggcgcgca?catcgcgttc?gcggaactcc?tctccaaccc?cctcggcctg?aagatcggcc 59100
cgggcaccac?cccggagcag?gccgccgcct?acgtgcgccg?cctggacccg?cacgccgaac 59160
ccgggcggct?cacgctgatc?agccgcatgg?ggcacacccg?ggtccgggac?gtgctgccgc 59220
cgatcgtcga?gaaggtcacc?gccgacggcc?accaggtgat?ctggcagtgc?gacccgatgc 59280
acgccaacac?ctacaccacg?gcgggcggcc?acaagacccg?gcactggaac?gcgatcgccg 59340
acgagatcac?cggcttcttc?gacgtgcacc?gggcgctcgg?cacgcacccc?ggcggcgtcc 59400
acctcgaagt?caccggcgac?cccgtcaccg?agtgcgtcgg?cggcaccgga?ggcccggcgg 59460
agagcgacct?gcccgaccgc?taccgcaccg?cctgcgaccc?ccgcctcaac?gcggaccagg 59520
cacgcgaact?cgcccacgtc?gtggcccggc?tggcggccgg?cgccgccgcc?caccgcgagg 59580
aaggaccacg?atgaccgcac?cgacccccgc?cgcgcccatc?ggcggcacca?cccggctgta 59640
cgccgtcctc?ggcgaccccg?tcgcccaggt?ccaggcgccc?gcgctgatca?accccctgct 59700
cgccgccctg?caccgcgacg?ccgtggtcgt?cccggtgcac?gcccggcccc?cgcacctgga 59760
gcccgtcgta?cgcggcctgc?aacgcgtgga?gaacctcgac?ggcctgttcg?tcaccgtgcc 59820
gcacaaggtg?gccgtccggc?gcctcgccga?ccggtgcggc?ccgaccgtcg?acatcgtcgg 59880
cagcgcgaac?gtgctgcgcc?gcgagcccga?cgggacctgg?ctcgcagaga?acttcgacgg 59940
ctcgggcttc?gtcgcgggcc?tcgtcgcggc?cggccacgac?ccccggggca?gcagggccgc 60000
actggtcggc?accggcggcg?cgggcagcgc?catcgccgcg?gcgctcctcg?cggccggcgt 60060
cgagcacctg?ctcgtccacg?acaccgacac?cgcgaagctc?ggcgcgctgg?ccgcccggct 60120
cgacgcgcac?tggccgggcc?gcgtgcaccc?gctcgccgcc?cccacgctgg?aggacaccga 60180
catcgcggtc?aacgccaccc?cgctcggact?gcgcgcccac?gatccactgc?ccttcccgct 60240
ggaacccctg?ccaccgggct?gcgtcgtggc?cgacatcatc?atgaaacccc?gcgagacacg 60300
gctgctgcgc?gaagccgccg?cacgaggaca?ccggatccac?cacggcattc?acatgctcga 60360
gggacaactg?aattcctacc?gggaattctt?cgaccttcgc?tgaaccacgc?cgacaactac 60420
cggaccgagg?gatgcaacgg?ccccggcgga?aacctaattt?ggaaaccgcc?gtcaaagctg 60480
ttccgtgcct?tggaatcgag?ccactcccag?tttcttggag?aatcatgaac?gtgcgacagg 60540
cgccggaata?cccccagtgg?ccgcagtacg?acgaaaagga?gcgggaaggt?ctcatccgcg 60600
cactcgagca?gggccagtgg?tggcgcatgg?gcgggagcga?ggtcgactcc?ttcgagcggg 60660
agttcgccga?actgcacggc?gccccgcacg?ccctggccgt?caccaacgga?acccacgccc 60720
tggaactggc?cctccaggtc?atgggagtgg?gaccgggtac?cgaagtcgtc?gtcccggcct 60780
tcaccttcat?ctcgtcgtcg?caggcggcgc?agcggctcgg?cgcggtcgcg?gtccccgtgg 60840
acatcgaacc?cgacacctac?aacatcgacg?tggcggcggc?agcggcggcc?gtgacgtccc 60900
gcacccgggc?catcatgccc?gtgcacatgg?ccggcttcct?ggccgacatg?gacgcgctgg 60960
ccaagctctc?cgccgacacc?ggtgtcccgc?tgctccagga?cgccgcccac?gcccaggccg 61020
cccgccggca?gggcaagcgc?gtcggcgaac?tcggcaccat?cgccgccttc?agcttccaga 61080
acggcaagct?gatgaccgcc?ggcgagggcg?gcgccgtcct?gttccccgac?acggagagct 61140
acgaggcggc?gttcctgcgg?cacagctgcg?gacgcccgcg?caccgaccgc?cgctacctgc 61200
accaggtcgc?cggcaccaac?ctgcggctca?acgagttctc?cgcggccgta?ctgcgcgccc 61260
agctcagccg?cctggagcag?cagatcgcca?cccgccggca?gcgctgggcc?gtgctctccc 61320
ccctgctcga?cgccatcgac?ggcgtcgtcc?cgcagcgccc?cgacgcccac?accgactccc 61380
cctcgcacta?catggcgatg?ttccgcgtcc?ccgggatcgg?cgaggacgac?cgcaacgccc 61440
tggtcgaccg?gctcgtggag?gccggcgtgc?cggcgttcgc?cgccttccgc?gcgatctacc 61500
gcaccgacgc?cttctgggag?acctgcgccc?cggacgagac?cccggagcag?atcgccgaac 61560
gctgccccca?cacggaggcc?gtcagccggg?actgcgtctg?gctgcaccac?cgcgtcctgc 61620
tcgccggcga?acaggacatg?caccggaccg?cggagatcat?cgcggacgcc?gtggccgccg 61680
tatgagtatc?aggacggccg?tcgtcgggct?cggctgggcg?gggcgggagc?tgtggctgcc 61740
ccgtctgacc?gagcacaccg?gcttcgacgt?ggtcgccgtc?gtcgaccccg?ccccgcgggc 61800
gcgtaccgtc?ctcgacgcgg?ccccgggcgt?gcccgtgcac?ccgacggcgg?acgcgctcac 61860
cgcccgcgcg?gtcgacctgg?ccgtcgtcgc?cgtacccaac?cacctgcacg?ccgacgtggc 61920
tgccgggctg?ctccgccggg?gcgtgagcgt?cttcctggag?aagccggtgt?gcctgacctc 61980
ccgcgaggcc?gacaccctgg?ccgccgccga?acgggacggc?ggcgccaccc?tgctggccgg 62040
cagcgccgcc?ccgcaccggg?cagacgtggg?cgccctggcg?aacctcctgc?ccggcctggg 62100
ccgcatccgc?cacgtcgacc?tgtcgtgggt?gcgggcgcgg?ggcatcccgc?aggccggcgg 62160
ctggttcacc?cagcgcagca?aggccggcgg?cggcgtcctc?ttcgacctgg?gctggcacct 62220
gctcgacacg?ctcacgtccc?tgctcggccc?cgcccgcttc?acccaggtcc?tcggcgtcac 62280
ctccaacgac?ttcctggaca?ccggcgcctg?gagcgccgcc?tggcggcagg?acgcggtgcc 62340
cgccccggcc?gccggaggcg?tggatgtcga?ggacaccgcc?cggggcttcc?tcgtccgcga 62400
cgacggcgtc?tcggtgggcc?tccgcgccgg?ctgggcgtcg?caccaggcgc?gggacgtcac 62460
ccggatccgg?gtgacgggca?gcgccgccac?cgccgaactg?cgctgcacgt?tcggcttcag 62520
ccccaaccgc?cacccccacg?ccgggctgac?gctgacgcgt?gagggcacca?cgacctccct 62580
gccggtaccc?caggagccca?tcggcaccga?gtaccggcgg?cagttggacg?tcctccccgg 62640
cgtcctctcc?gacccgggcc?accgcggcag?gaccgccgag?gaggcccgta?cgacggtccg 62700
cgtcatcgag?gacttctacg?ccgcggcccg?ccgcgcgcac?gagcagaccg?ccgtgcccgc 62760
ccatcactag?aaggtgagga?agccggtgac?atcacccctt?tcgacagggc?cggcgtggct 62820
cgcgcagcgg?cccaccgccc?cgggcgccgg?acggccggcg?acggggacgc?tccggccggt 62880
cagacgcgcc?gtggtcttcg?acctggacgg?agtcctcgtc?gacagtttcg?cggtgatgta 62940
cgaggcgttc?gccgtcgcgt?acaaggaggt?cgtcggcgac?ggccccgcgc?cgttcgacga 63000
gtatcggcgc?cacctggggc?gcttcttccc?cgacatcatg?cggatcatgg?gcctgcccct 63060
ggagatggag?gagcccttcg?tccgcgagag?ctaccggctc?gcctcccagg?tgccggtctt 63120
cgacggcgtc?gtggagctgc?tcaccaccct?gcgggtgcgc?ggctaccggc?tcgccgtggc 63180
caccggcaag?agcggggagc?gggcccggtc?gctgctcggc?gggctcgggc?tgctgccctt 63240
cttcgaccac?gtgatcggct?cggacgaggt?cgcccgcccc?aaaccggccc?cggacatcgt 63300
ggagcacgcc?ctggacctga?tgggcttcac?gcccgagcag?gccgtcatgg?tcggtgacgc 63360
gccgaccgac?atcgccagcg?cccacggcgc?cggcgtgacc?tcggccggcg?cgctgtgggc 63420
gctgtccgac?gccgaggaac?tgctcgccgc?cgggcccgac?atcgtcctgg?cccgccccgg 63480
tgacctgctg?gccctgtgcc?cctccgtacc?cggtgactga?ggacgggccc?tgcctcggtg 63540
tcgacatcgg?gggcaccaag?gtcgccctgc?gggtcgaggc?cggcgcgcgg?tgcgtggccg 63600
agaccgtctt?cgcctggcag?ccgcggcaca?gcgccgaccg?cgacctcgcc?caactcgccg 63660
cgcacgtcgg?cgggctgagc?gagcggctgg?ccgtcccccc?gagggcggtg?ggcgtcgccg 63720
taccggcgac?cgtcggaccc?gacgagcggg?tcaccgcctg?gccgagccgg?cccgagtgga 63780
ccggcacgga?cctcggcgcg?gcgctgcgcg?cactgctgcc?gggcacgccc?gtcgcctggg 63840
cggacgacgg?cgacctcggc?gccctcgccg?aggcacgggc?cgccgactgc?gccgacctcc 63900
tctacatagg?ggtcggtacg?ggcgtcggcg?gcggcctcgt?cctgcgcggc?gacctctgcc 63960
cgggtctggg?ccgcggttcc?ttcgagatcg?ggcacacggt?cgtcgacctg?gacggcccgc 64020
ggtgcgtgtg?cggacgccgg?ggctgcctcc?aggccatcgc?ctcgggcccg?gccaccctgc 64080
gccacgcggc?ccggctgcgg?gggagcgacg?tcgactacga?cgcgctgcgg?cgggcctggc 64140
tggacgcggc?cccctgggcg?gtgacggccc?tgcgccgcac?ttgccgggcc?ctggccgccg 64200
ccgcgaccgg?cgtccaggaa?ctgctccgtc?cgcggctgct?gctgatcggc?ggcggcttcg 64260
cgagcggcct?tcccggcctg?gacgccctcc?tgaccgagca?cctggccggc?ctcgcccgtc 64320
cgggccaccc?acccctcacg?gcgcgccccg?ccgccctggg?cggcctgtcg?tccctgcgcg 64380
gagcggtgga?actcgcccgc?ctgacgcacg?cgtgagggcg?ggcgcgtgag?cgggtgaacg 64440
ccggggtgct?cgagcgcggc?aagcgctgcc?gcccacgctc?gtgcgcctga?gcgctcgtcg 64500
ctcaggcacg?ggtgccccgg?tcaggtcctg?cggtgcggtc?cccccgccgg?cacggccgtc 64560
gccaaccggt?cgcgcaggca?gtcgacgagc?gcggcggtgt?cctcggcgcc?gcgcgcggca 64620
ccgaagacgt?ggtggtccgg?gcggaccatg?agtgcgctcg?cgtcgtgctc?ggacaggtac 64680
gcccggtaga?agccgtccgt?gtcgatgacg?tccgtcaggc?ccggctcggt?gtcctcgggc 64740
ggcaggaccg?tgccgggcgg?tgacaggcgc?accacacggg?tgtcgagagc?cgcgaggaag 64800
gaccaacggt?cctccccgag?cgccgggcgc?ggatcgtccg?tggtgagcag?cacgaagccg 64860
ccccccacga?ccgcgtcgaa?caggcccgtg?ccgcccgccg?tgctcacccg?ccactgcggc 64920
accacctcgc?cggccggcgc?ccgcggcgcg?cccgccggcg?cccgcagcag?cccggccgac 64980
agcggcttcg?ccgcatccgg?cgcccccggc?cccgtacgac?cgcgccggcc?cgccaggacc 65040
gtggcgtccc?gctccgcggc?ggccgcgggg?tccgtcacac?agatcacccg?gccgagctgc 65100
accgacgaca?ggatcgactc?cttcacgtgc?tgccgccgct?cctcggcgta?ggtgtcgagg 65160
agcgacgcgt?cggccaggcc?gcgcagcgtc?aggtccagct?tccacgccag?gttggccgcg 65220
tcccggatcc?cggaacacat?gccctgcccg?gcgaacggcg?gcatgaggtg?ggccgcgtcc 65280
ccggccagca?ggacccggcc?cgagcgccac?tcgtcggccc?aggcggcccg?gaagatgtag 65340
gtcgtgctgc?gcagcagcgt?ggccgtctcc?ggagtgacac?cgaacggctt?gagcaggcgc 65400
caggcggtct?ccggacggtt?cagctcggcg?ctgctctcgc?ccggcagccg?catgaactcc 65460
cagcggcggt?gccccggccc?gctgccgacg?agcgtcgtgg?gccgcgccgg?gtcgcagatc 65520
tggacgttgg?tgggcgtgaa?ctcgcgcggt?tcgcgcagct?cgacgtcgca?cagcagccac 65580
tcgtaggaga?accccaggtc?ggtcatgggg?acgccgaggt?gctcgcgcac?gaagctgttg 65640
gcgccgtcgc?agcccacgac?ccagtgcgcg?acgaccgtgc?gggcggctcc?gtcgtcggtc 65700
tcgacggtca?gcgacacccg?gtcgtcccgc?tcggcgaggt?ccacgacccg?gcgcccgcgc 65760
agcaccgtga?cgccgggcag?cgccgcggcg?cggtccgcga?gcagtctctc?cagcgccggc 65820
tggtgcatgg?tgttggcgtc?cggccagccg?tagcgccccg?tcggggagaa?ggcgatgtcc 65880
agcagcgtct?cgcccgccgc?ggtgtgccac?tggtagccgg?tggccggctc?cgtgatctcg 65940
ccgaaccggt?ccccgacgcc?cgtggccgcg?agcagccgcg?cggtctcccc?gtcgaagctg 66000
gtcgcccgcg?gcagcaggta?cggccggggc?cggcgttcga?ggacggtcac?gcgcagcccg 66060
cgctgggcga?gcagcaccga?cagcgccgcg?ccgaccggcc?cgttgccgac?gacggccacg 66120
tccgtgtccg?tgccggtgtc?cgtcggggac?tcgtaggggt?cgtgcgggcg?cgtggtggac 66180
atcgtcatcc?caactcgcag?gggtcgaaga?gcgcgagggc?atggaaacgg?cactggatcc 66240
gcactgccgg?catcggctgc?ccgagtgtcc?ccaccgtccc?gtggattcct?cccggagccc 66300
cgctcgagcg?ccgcccggag?taccggatca?cccgcccgcg?gtgagcgccc?gggccgggca 66360
caggtcgact?gcctcgtcgg?ccgccggcca?cagggcctga?ccgggctccg?ggtccagcac 66420
gaccaccacg?ccgtcgtcct?cgccctggtc?gaacagttcc?ggcgcgacgc?gcacgcactg 66480
acccgcgccg?acgcacttgt?cggtgtccgc?gaatatcttc?acagcgatcg?cctcctacga 66540
gtggaatgca?ggccgtcggc?catgatgccc?gaggaatacg?gcacaccgtc?ccggacgccg 66600
tgattccccg?gtgccgctcc?agtcggattc?gagcgcacgc?ccataaggac?cgcggtgaaa 66660
aggcgagagg?cggcggacca?gccacggctt?cgatctatca?gatcgaggga?tatcgggccc 66720
gcgaagccct?tcctattctg?tcgctggaca?tgtgcatcac?gggaccggcg?cggttctcat 66780
tccgtacgtc?cgtcgatccg?tgacggggaa?agcggcgtgc?cggacgacga?ttcctgaagg 66840
gaattaaggc?cgtgcctcga?accccggagc?aattcggaac?atgggtccgc?cggttccgtc 66900
cggtgacgga?cgccgacgtc?cgcctcgtgt?gcctgccgca?cgccggcggg?tccgcgagct 66960
tctactttcc?gctgtccacg?tcgctcacgc?ccgccgtgga?cgtcctggcg?gtgcagtacc 67020
cgggacggca?ggaccggcgc?cacgaaccga?acatcgacag?ccttcccgag?ctggccgaca 67080
aggtcttcga?ggcgatacgc?cacctcgacg?accggccgct?ggcgctgttc?ggccacagca 67140
tgggcgccgt?cctcgcctac?gaggtcgcgc?tgcgcctcca?cgacgccgga?ctccccgccc 67200
ccgtacggct?cttcgtctcc?ggacggcgcg?ccccctcccg?ggaccgtgac?gaacggctcc 67260
acctgagctc?ggacgagcac?ctcctggccg?aggtgcgcaa?gctgggcggc?ccgcacgcgg 67320
cgctgctcgc?cgagccggac?gtacgggaca?tgatcatgcc?ggcactgcgc?ggcgactacc 67380
gcgccgtcga?gagctaccgc?tgtgcgcccg?gccggcgcct?ggagtgcccc?gtgacggtgc 67440
tcaccggcga?cagcgacccc?cgcgtctcgg?tcgacgaggc?gacggcctgg?gaggagcaca 67500
ccaacggccc?gacggagctg?gaagtgttcc?ccggcggcca?cttcttcctg?ctcgaccaga 67560
acgcgcgcct?gacccggctc?ctcgcggacc?gcctgcgccg?ccggcccgtc?ggcgcgcccc 67620
acgaagcccg?cgtctgaggt?gaccgagttg?aacacgcccg?tccccaccat?cccccaccac 67680
tcgctcctgg?tgttcctcct?ccagcttgcg?gtcctgctcc?tgctggccct?gtccctggga 67740
cagttggccg?cacggttcaa?gatgcccgcg?atcgtcggcg?aactgctcgc?cggagtgctc 67800
gtgggaccct?cggtcctcag?ccacgcctgg?cccgccctcg?ccgactggct?gatgccgaag 67860
gacaccgccc?agatgcacat?gctcgacgcg?gtcgggcagg?tgggcgtcgt?gctgctcgtc 67920
ggcatcaccg?gcatggagct?gaagttcgac?ctcgtcaggc?ggcgccggct?caccgcggcc 67980
cgggtgagcg?tctgcggtct?ggtcctgccc?ctggcgctcg?gcgtcggggt?cggcttcctg 68040
ctgccctcct?cgatccggcc?ggacggcacc?agcccgacgg?tcttcgcgat?cttcctcggt 68100
gtggccttgt?gcgtcaccgc?gatccccgtg?atcgccaaga?ccctgatgga?catgaacctg 68160
ctgcaccgcg?acatcgggca?gctcaccctc?gccgccggag?tcctcgacga?cgtcgtgggc 68220
tggttcctgc?tctccatcgt?gtcggcgatg?gcgacggccg?gactgagcac?cggcacggtc 68280
gccacgtccc?tgctgtatcc?cgtcggcgtc?gtcctggccg?cctgggtggt?gggccgcccc 68340
ctggtgaagg?cggcgctgcg?cgcggccggc?cgctccgcgt?caccggtgcc?caccgtcgcg 68400
gtgacggcgc?tgaccgtgct?gctgggcgcg?gcggcgaccc?aggcgctgca?cctggaggcg 68460
gtcttcggcg?cgttcgtgtg?cggtgcgctg?atcggcacga?gcgggcagct?ggaccgggag 68520
aagctggccc?cgctgcggac?caccgtcctc?gccttcctcg?caccggtctt?cttcgccacg 68580
gccggtatcc?ggatggacct?gaccgcgctg?accgacccca?ccgtcctggc?cgcggcctgc 68640
gcggtgctcg?ccgtggcgat?catcgggaag?ttcgccggcg?ccttcgccgg?cgcgaagatg 68700
agcggcctcg?gccgctggga?gggcctcgcc?ctcggcgccg?gcatgaactc?ccggggggtg 68760
atcgaggtcg?tcgtggcgat?ggtgggtctg?caactcgggg?tcctcagcgc?cgaggcgtac 68820
accatcgtca?tcctcgtcgc?gatcgtcacc?tcgctgatgg?cgccgcccgt?gctgcgcgtc 68880
gcgatggccc?ggatcgacga?ggacgccgag?gcggggatgg?gcatggccgg?cacggcaccg 68940
cgcgacctgg?cggcgccgcc?gtccgcctcg?gtgtgagcgg?gggagaggtg?cgggacgtga 69000
cgacggcggg?gacgtaccgc?ggcggacgac?tgctcgccat?cagcgacctg?cacgtcggcc 69060
acgccgacaa?ccgtgccctg?gtcgagcgga?tggcacccgg?gacggacgag?gactggctgc 69120
tggtggccgg?tgacgtggcg?gagaccgtca?ccgacatcca?ctggtgtctg?aagaccctcg 69180
ccggccgctt?ccgcaaggtc?gtctgggtgc?ccggcaacca?cgagctgtgg?acccacccga 69240
gcgacaccgt?caccctgcgc?ggtgtcgcac?gctacgagca?cctggtggaa?ctctgccggg 69300
acctcggcgt?cacgacgccc?gaggacccct?acccgctctg?gcacgggccg?gacgggccgg 69360
tggtggtggc?gccgctgttc?ctgctgtacg?actactcgtt?cctgccggcc?gggtgcgcca 69420
ccaaggacga?gggactcgcc?tacgcgcacg?agaccggcgt?cgtgtgcaac?gacgagagcc 69480
tgctccaccc?cgatccctac?ccgagccgtg?aggcatggtg?ccgggcccgg?gtcgccgaga 69540
ccggacgccg?gctcgccgca?ctgcccgacg?ggacgccggt?cgtcctggtc?aaccactatc 69600
cgctgcaccg?gcacccgacg?gaggtgctgt?ggtacccgga?gttcgccatg?tggtgcggca 69660
cccggctgac?cgccgactgg?caccgcaggt?accccacggc?tgccgtggtg?tacggccacc 69720
tccacatccc?gcggaccgcc?caccacgagg?gcgtccgctt?cgaggaggtg?tccgtgggct 69780
acccccgcga?gtggcgcagg?cggcagaccc?cgccgggcac?gccccgcacg?atcctgtgac 69840
cggtgtccgt?gcggcggccc?gggctcagga?ggccctcgcg?ccttcggggt?acgcgcccgg 69900
cacccggctc?caggcccgcg?tcagttccac?ccgcgaggcc?acgttcatct?tccggaagat 69960
cttcttcagg?tggaaggcca?cggtgtgccc?ggagatgaag?agccgttccc?ccacctgtga 70020
gttggtgaac?ccctggctca?ccagctcggc?cacggcggcc?tcggtgttgg?tgagcgagcc 70080
ggcgtccggg?ccgctccggc?cggcgtactg?cggatggcgg?ccccgccgca?cgccgagcgc 70140
acgcaaccgg?ctcgcgaccc?gccgcgcgtc?ccgcggggcc?ccggcccccg?cgtagccgtc 70200
cgccgccgac?tcgaaggccg?tgacggcccg?ttggcgttcg?gcgggccgcg?cggcgaggaa 70260
cgtgcccgcg?tcctccgcgg?cggacgcggc?ggcccacggg?tcctggtgcg?cggcggccgc 70320
ggcgagcagc?ccgtccggat?cgccgtccag?cagcccggcg?gcatgccccg?ccgccgcgcc 70380
cacggagcac?agccccgggt?tgcgcaccgc?gagcgcgccg?gctcccgcca?ccacccgccg 70440
ggcgagtacc?tcgtcaccca?gcttgcgggt?ggcccgcacg?agccaggcgg?cggcggtggg 70500
ctgggaggtc?agcagctcca?gcagcaaccg?gtcgtccgtg?acgatgcccg?cgatgagctg 70560
ggccgcgctc?gccgggccgc?cctgcacttc?gaggagctgc?gccgcagccc?aggcgcactg 70620
gctcggcccg?tgcgcggtcc?ggccgagcag?agcgcagtcc?cgtagctcat?cggcgaactg 70680
cgcactcaca?ctcatgtcgc?cctgccgaag?cgcgccgagc?gccagcacgg?tgtgcgcgtc 70740
gggcaggaag?ccgtgcagcc?cggcccgccg?cgcgcggtcg?gcaccccggg?cggcgagatc 70800
gacggctgcc?gaggtgtcgc?ccctggcgaa?ggcgaggtcc?gccgcgccga?gcagggaggc 70860
gacggcggta?ccgccgtcgg?cgtccgaccg?ggccgacagt?tcgtccacct?cggccaggac 70920
cagcgcggcg?gacgacagcc?ggcggaccct?gaccagcagt?gccgcgtgcc?aggcccgtgc 70980
cggcgcttcg?cagttcccgg?cgcaatcggg?ttccgttcga?acagcggcct?ctgccaggcg 71040
gataccttcc?tccagatccc?cacgggacca?ggcggagaaa?gaggattctg?acagggcgga 71100
ggattcgcag?gcgttgttcc?ggcagacacg?taggacggag?aaaacggggg?gcagccgcag 71160
gcgaaacgga?gaatcgagca?tcacatctcc?agtcatggga?tccgtgccgt?ccgagtgggg 71220
tccgtgcgcg?gaccaggtta?gggcgggggt?gcgggcgggg?cggtgcgggc?cgacggggcg 71280
tgtagagggc?ctcgacgtgc?gtacgagcgg?tccttgagcg?gcgcggccgg?gtgcgcgggg 71340
gacggctccg?gaagcgggac?tatcagctct?gagggtggcg?cgcggcgaag?tgcggcgaca 71400
gcatggagga?aatcccgact?ccgccggccc?cgcggccgag?acgagcgggc?cgcggcgaat 71460
gcagaggtgg?gcctcttgag?taccgtgctt?ctcctgaacg?gcccgaatct?gggaattctc 71520
ggccgccggg?aaccggagat?ctacggcacg?gacacactcg?ccgacatcga?ggcggcggtc 71580
gccgacgaac?tgagcgaccg?gggctggaag?gtgctctccg?tccagcacga?ctcggagggc 71640
gacctcgtcg?gcgccgtgca?ccggcacagc?gacagcaccg?tgggagccat?cgtcaacccc 71700
ggcgccctga?tgatcgccgg?ctggagtctt?cgcgacgccc?tcgccagcta?cgcgccgccc 71760
tggatcgagg?tgcacctcag?caacgtgtgg?gcccgggagc?agttccggca?cgagtcggtc 71820
atcgccccgc?tggccagcgg?tgtcgtcgtc?ggcctcggag?cctacggcta?ccgtctggcc 71880
gcccgggcgc?tcacgcatct?ggcgccggcc?ccgctctgac?ccctgcccgg?ttcacgccgc 71940
ctccccggcg?gccggcagcc?cgatgcccgg?gtagtacgtg?cgctgccggg?agaggaccat 72000
cgccttcggc?gacgccagtc?ccacggtctc?gcggatcctt?gccgccagcg?cgcgcgagga 72060
gaccgggtgc?acaccctccg?cccggcacca?ctcccggtac?gccgcgtgca?gccgggtctg 72120
ctcggcccgc?agcgcggggc?cgagggcgca?cacctccgac?acgaagcgcc?ccatgtggtc 72180
ctcggtctgc?ggcctcggag?aacatcggta?cagcggttgg?cgctgagaac?gatcatggtc 72240
agggcgcgag?tctgctgacc?cggttctcgt?actcacggcg?ggccttgcgc?tgggccggga 72300
cggcggggac?gccttggccg?ccgtcgagcg?gctggcagcg?ggcgaggagc?tggcggtgga 72360
tggcgggggc?ggcgttgacg?cgcagggtgt?agccctggcc?gcgccgtacg?gtcacccctt 72420
ggtcgagcac?ggcccgctcg?gcgggctcca?gctcggtggt?gcggaggtag?tcggcgacct 72480
tgcccggcat?gtcgagcgtg?accggcagtt?ccggggcggg?cgcgtcctcc?ttggtggcgg 72540
tgtgctcgag?caggaggtcg?gcgacggctg?tgcggatggc?gccgcggctg?acgtcgtggt 72600
cgcgggcgag?ggcggcgatg?gagcggcctt?gaaggtacgc?ggtgcgcacg?tcggcggccg 72660
tcgcggccgc?gacggcgggg?cggcgcccgc?ccttgttgcc?cttggcctcg?gcggcgcgca 72720
gtccgtcgta?ggtcagctcg?cgctggaggt?cgcgctggag?ttcgccggcg?gcggcgaggg 72780
tctgcaccat?gaacttcacg?gtggacagca?gctcgccggt?gcgggggtgg?cgggcggtga 72840
ggtccatcgc?agagaacgcc?ccatcgtgga?tgcgcagggc?gaggcggtcg?cggtgaagga 72900
cgtcgagcac?gtcgaggatg?tgctggttgc?cgcgcacgag?gcggaacatc?tcggagatgt 72960
gcacggtgtc?gcccggccgc?gcataggtga?gcagctcgcc?gaacttcgga?cgctggagcg 73020
gatgaaggcg?gctggaggtg?ccggggtcct?cctcgaagac?gaccgggtcc?tcgatcccgg 73080
cttcggccag?gacgaggtcc?tgccgggcgg?tggactgctg?gtcggtcgag?acccgcttgt 73140
agaccaggtt?cgccaccgtg?ggccccttcc?gtacggagga?tcggacccta?tctgtcgtca 73200
aaccctgtca?gcaatcacca?tcggatctga?ttggattcgg?gtcgcctcga?accccgggat 73260
tacacgggtt?cattggacgt?cccggccgcc?tgtcgtcaaa?caatcgtttg?acgacagggc 73320
ggcggtcccc?ggcttgctgg?tgctgatgaa?gtcactgaga?tggttgtgca?cacaaccaag 73380
atgccgacgg?accaccagat?ggcggtcgag?gggccctcgc?ccctgcctac?gtcctggtgc 73440
ggcttcagcg?tggccgaggt?gtcgcgtggg?ccttcttttg?cttgcgcggt?atcgctgtca 73500
gtcggcgagc?gtggtgtagt?cggtgtagcc?gcgggtgtcg?ccgccgtaga?acgtggtggg 73560
atcgggttcg?gtgacggggg?tgtggttctg?ccagcgccgg?acgaggtcgg?ggttggcgat 73620
gaaggccctg?ccgacggaga?cgaggtctgc?ccggccgctg?tcgatgtgcc?ggcgggcggc 73680
ggtggcgtcg?gtcatcgggt?accagccgtc?gttgacgatg?agcgtgccgt?cgaagcgggt 73740
ccggaggtcg?gtgagcaggg?gtgtggcggg?gtcaccgatg?gtgtgcaggt?aggcgagccc 73800
cagcggggcg?atcgcgtcga?tgagggtgcg?gtaggtcgcg?gcggtttcgg?ccgggtcgtc 73860
ctcggtcgct?ccgtgcaggt?tgatgcccgg?cgagatgcgc?aggcccacgc?gttcgctgcc 73920
gaccgcctcg?gccacggccg?tcgccaggtc?gatcgcgaag?cgtgcccggc?ctgtcgtgga 73980
tccgccgtag?gtgtcggtgc?ggtggttggt?ggacggtgcg?aggaactgat?ggatcaggta 74040
gccgttggca?ccgtgcagtt?cgatgccgtc?gaggccggct?tcgacggcgg?cgcgtgcgct 74100
gtccacgtac?tcctcgatga?ccgaggggat?ctccgccgtg?gtcagggccc?gcggtaccgg 74160
gtgtggcctg?ggcccgctcg?gggtgaatat?ctcgccgggc?gcggcgaggg?cgctgggggc 74220
tacggtttca?tggccgttct?tgttgtccgg?gtgcgcgatc?cgtcccgcgt?gcatgatctg 74280
ggcgactata?tggccgcctt?cctcgtgcac?gccgtcggcg?acggcgcgcc?atccgcagat 74340
ctgacggcgt?gtgtggaggc?caggggtgtt?ggagtagccc?tgcccggttg?cgctgggctg 74400
gacgccttcg?gtgatgatca?ggccggcagt?ggcccgctgt?cggtagtagg?tggcggtggc 74460
ctcgccgggc?acgccggagg?cgtcggcgcg?gctgcgggta?tgggggccat?ggcgatccgg 74520
ttgggcagtg?tccacttgcc?gacggttacg?gggctgaaca?ggtcgggcat?ttggggtttc 74580
tccttggggt?ggttgtgtct?gtcggcggtg?gccggtcggt?cgggtcgggt?ggtcatgtgg 74640
cgaggcggcg?gatggcgatg?accgtgtcgg?tgacggtggt?ggtctatccg?gcggggccgg 74700
ccgatgcccg?gccggtcgaa?ctgctggtgc?tgttcggcag?ccagggcgag?cgcgcccatc 74760
tgcgggcccg?aaccacctga?cggccggtgg?gcgggcatgg?gtgcgtcagc?cctgctgtga 74820
cggcccgaga?ggcaacaggc?cgtccaggcc?gtggcggcgt?tcgcccatga?cctgctcgca 74880
cagggccgcc?tccgcctcgg?gggtgaagac?gcccgcgacg?gaacgggtcc?ggcggcgggc 74940
gagtgcggcg?tcggtgtcgg?cggccaccag?gtcggcgttg?atggccgcgg?ctgcccgtac 75000
gccggcggcg?gccgcggccg?ggactccgtc?caggacgtcg?gccacgttcc?ccgcgaccca 75060
caccccgccg?gccgcagtca?gtccggtacc?gtccgcgccc?acctgatcgc?cgatggccca 75120
cggatgctcc?acggccgtca?gaccgagctc?ggcgaggacg?tcgtcccggg?cctcgaaccg 75180
gggagccacg?accagcgcgg?cgagcggagc?ccgatctccc?gatgccagtc?ggacaccggt 75240
caggcggtcg?tcctcgattt?ccaggtccgt?gacgtccccc?tccaccaccg?cgacccctcg 75300
ggccgccagc?ctctccccgt?cctcgacgcc?gagttcaccg?atgctgtgcc?ggaacagggt 75360
gacctggtcg?gacagctggc?ggaacagcag?cgcctgatgg?acggccgccg?ggccggtggc 75420
gagcaccccg?accggctgat?cccgtacctc?ccagccgtgg?cagtacgggc?agtgcagcac 75480
gtcccgcccc?caccgctcgc?gcagcccggc?gatgtcgggc?agccggtcga?cgagcccggt 75540
gcacatcagc?agccgccgtg?cccggaaccg?gtgtccgcca?gccgtgtcca?ccacgaatcc 75600
gtcgccgtcc?cggcctgttg?tgaccacccg?gtcggagatc?atccggccgc?cgtacgagat 75660
gacctcctcc?cgccccacgc?gcagcagttc?gctcgggttg?atgccgtccc?tcgacagcag 75720
gccgtgcaca?ccggacgccg?gggcgttgcg?gggttcaccg?gagtcgatca?ccaccaccga 75780
acgccgggac?cgggcgagcg?tcaccgcgcc?cgacagaccg?gcgactccac?cgcccaccac 75840
cacgacatcg?acatcggcgt?cgccgacgac?ctcggtatcg?acaccacctg?ggctgttcgc 75900
gatctcagtc?ataccaacag?cctcacccgg?cacctgtccg?gtgcccagaa?accatgctgt 75960
ttcggcaaga?ttccggatcg?cttccggccc?gggcagcagc?gcaggccgtc?gatcaccagg 76020
tgcagcagcg?gagttgcctg?gtcggtggaa?ggaagtcacc?ctgttcctgc?acgagggcgc 76080
ggggctggcc?caggagcagt?gggaacagct?gcctgctctg?ggcgcgggtg?tggtcgaggg 76140
ccggatcggc?gctcggaggc?cgaggtgtcg?cggcgggtgc?tgagcccgcg?cgtgcatggc 76200
ctggagggtc?tcgtggacgg?tcgctgaggg?gtgctggcgt?cttcgccggg?ggcgtgattc 76260
aggtggtgcg?ggccttgagg?tgggcccgct?ctccctgggt?gccgaacagg?atcagcagtt 76320
ctacggtgcg?gtcgtcgtcg?gggccgagcc?agtgcggcac?gtgggtgttg?aactcggcgg 76380
cctcaccggg?cttgaggatc?actctctcct?caccgaggag?caggcgaagc?cggccggcca 76440
ggacgtagac?ccattcgaag?ccctcgtggg?tactcagatg?cggcgcggtg?ccgggccggg 76500
gcggaatgag?tagcttgtga?gcctggacac?cgccgggccg?gctcagcggc?acgtaggtca 76560
tgccgtcgcg?gacgaccggt?ttgaggtgga?tgcgcgggtc?cccggtgcgc?ggtgcgccga 76620
cgagctcgtc?caggggtacg?gcgtagacct?cggcgagcgg?cagcagcatc?tccagagtcg 76680
gtttgcggct?cccgccttcg?aggcgggaaa?gggtgctctc?gttgatcccg?gtctgctggg 76740
ccagagcggc?cagcgtcaga?ccgtgcctgc?ggcgcaggtc?ccgcagccgc?ggcccgaccg 76800
cggtcagacc?gtccttcttc?ccgatgtgcc?gtgcggcgct?catacccacc?agcatgctga 76860
aacagcatga?agctttgcaa?ctccagcagt?ggccatcgca?gtgtcgtacc?agcggcccgc 76920
ccgattgccc?ggtggcccgc?aaatgacctg?cccttttccc?ttgatctgct?gaggactggc 76980
ccctgcgatg?acgacggaaa?ccgacgcggt?ggaccgccgt?gaggacgctt?tggacccacg 77040
gcgctggtgg?gcgctgacgg?tgatctcggt?ggcgacgctg?atggtggtgc?tggacgcctc 77100
cgtcatcaac?atcgccctcc?cgcacgccca?ggccgacctg?gacatcagcg?acgcgaaccg 77160
gcagtgggcg?gtgaccgctt?acgccctcac?cttcggcggt?ctgctgctgc?tcggggggcg 77220
cgtcgtcgac?ttcgtcggcc?gcaagcgcgt?cttcctgatc?ggcctaaccg?gcttcgccgc 77280
cgcctccatg?ctcgcgggca?tcgccccgaa?cgggatgacc?ctgttcgccg?gacgcgccct 77340
gcaaggcgtg?ttcgccgcac?tgctggcccc?ggccgcactg?tccctgatcg?cggtcacctt 77400
caccgaccca?cgcgagcggg?ccaaggcgtt?cggcgtctac?ggcgccctgc?aaggtgcggg 77460
cggcgcggtc?ggactgatcg?caggcggcct?gctgaccgag?tacaccagct?ggcgctggtg 77520
cttgttcgtc?aacaccccca?tcgccctcgc?catggccctg?gccgcactcc?cggtactcaa 77580
ggagagccgc?gccgagggca?cccgccgcta?cgacatccct?ggcgccctgc?tggtcaccac 77640
cggcctggtc?gccatcgtct?ggggcttcac?ccacgccgcg?gaagcgggct?ggaacacccc 77700
ggcgacctgg?ctcctgctca?ccgccggcct?ggcgctgctg?gcctcgttcg?tcctggtcga 77760
gcggcgcacc?gcccacccgt?tgctgccgct?gcgcgtcatc?tgggaccggg?accgcggcgg 77820
cgcgttcctc?gcctccctgc?tgatcggggc?gggcatgttc?ggcctgttgc?tgttcctgac 77880
ctactacctc?caggtcaacc?tcggctacca?gccgctgcgt?gcgggactgg?cgttcctgcc 77940
cttcagcgcc?ggcatcatcg?ccgcggccac?cttcggcgcc?ccgctggtca?cccggctcgg 78000
tccgaagacg?ctgatgacgg?cgggcacggc?cgtcaccctg?gccggcaccc?tggtgttgac 78060
gctgctcaag?cccaccgagg?gctacatgac?cgtcgtgctg?cccgccatga?tcctgaccgg 78120
tctcggtctg?ggcgcgttct?tcgtcgccct?gcccaacacc?gcccttgccg?gcatcgcccc 78180
gtccgacacc?ggtgtcgcca?gcgcgatgat?cagcaccacg?cagcaggtcg?gcggcgcagt 78240
cggccccgcc?ctcctcaaca?ccctgtacgt?ctccgccctc?actgggtttc?tcgccgaccg 78300
caccggcgcc?gtgtcgcagg?cggtccggct?ggagggatac?gtgcacggtt?accgggtcgc 78360
cttcctcgcc?agcgccgccc?tgttcgccct?cgccctcgcg?gccgccggcc?tgctcatcac 78420
cagccgccgc?accagcgccg?ccacctcctg?accacccgca?ccgaaaggcc?ccgcacatga 78480
acagcgccaa?cgagtccgcc?acgttctggg?agaagcacta?cgccagcatg?gacgcgcagt 78540
ggggcaccaa?gcccaacgcc?gtcctcaccg?ccctgctcgc?cgacctggcc?cccgccccgg 78600
gcacagccct?ggacctgggc?tgcggccacg?gcggcgacgc?actctggctc?gccgcccagg 78660
gctgggacgt?cacacccgtc?gacgtctcgc?agacggccct?cgaccgcgtc?gcggcaggcg 78720
ctgcggccac?tggcctcacc?gaccgggtcc?acccccagca?gcacgacctc?tccgaaacct 78780
tccccgacgg?cgcctgggac?ctggtcaccg?ccacctactt?ccacactccc?gtcaccattg 78840
cccgcgacag?cgtcctgcgg?cgagctgccc?aggccgtagc?acccggcggg?cggctgatcg 78900
tgatcgaaca?cgcctccacc?gccccctggt?cctggcaggc?cggtcaggac?atccgctacc 78960
ccacccccga?cgacgtcatc?gcctcactcc?agctcgacga?cacctgggcc?gtcgaacgag 79020
gcgacgcacc?ccagcgcacc?gccgccggac?cagaaggaca?gaccgcgacc?gtaaccgaca 79080
acgtcatcgc?cgtccgacgc?accagctgac?acagccagaa?cagagccaca?gccaccctgg 79140
ctccacacca?ccccggcgtc?cgccggagca?caccatgaaa?ccggcgccgc?ttcagcccgc 79200
cccgtcgtca?tcgtcgtcca?actccggccc?gtccgggtta?cgcaacggac?gcagggcgcc 79260
ggcggccggg?gtcgaggcgg?tgaagctgta?gcggccgagc?aggttcaggt?tgcggtgctt 79320
gagcggagac?agggagtcgc?gcggggtgcc?ggggacggcc?gcccagagcg?cggccacgtc 79380
caggtccgcc?tcgtgctcct?cgaccagctc?caactcctct?aacagcgcct?tcgccgcccg 79440
cgcgagcacc?cgtgacgcct?tctccagctg?cggcagcgtc?gacagccgct?ccttctccgt 79500
cttgcgcttc?gcggtgttca?gcagccgggt?ggccatgagg?acctggaaca?ggtccagggc 79560
ctcgtcgatc?gccttcgcct?ccaggtgccg?catcactgcg?gtgagcatcg?ccgtgcgctt 79620
cggctcctgc?gcccgctcca?gcagcggcgc?cttcgacccc?agcgcgtacc?gggccaaagc 79680
ggccatccgg?ttcggcggga?tctgcgacag?cctcagccgc?ccgagccggt?acgcgccgat 79740
ctcgtcaacc?cgctccagcg?cacgggcgaa?cgccgtgccc?gtcgtccgcg?tcggcggccg 79800
gcgcagccgc?tccagctccg?agaaccgcga?gccctccggc?gtcttcagcg?tcgccaccag 79860
gtccccggga?agcgccgggt?ccgcgcggcg?ggccgcgccc?ggaccgtggc?gtgcagccgc 79920
ttctccgcga?ccttccgcac?ctccgacacc?tgccgggcca?gcaccgacac?cccgggcaac 79980
agcacccggt?tgcggcgcag?ccagcccacc?gcgtgatcga?acagcgcctt?cgggccctcg 80040
gcgtgcgtcc?atgctcgccc?gtgcaggaag?gtgcggaacc?gccgggacca?ctccgggtcg 80100
tcgtactcgt?ggtattcgta?ggcgtcccgg?atctcccacg?cgtgctcgta?cgccgtcttc 80160
ggccgctcgg?tgtaccgctt?caccaccgac?gggtcctcga?tgccgagctg?cgcggccagg 80220
tgctcgacca?ccggccacgg?tgcgtccagc?gggtcgtccg?ggaggaaccg?gccgatgtag 80280
cgcaccgtgc?acatctggag?cgcgaagccg?agctggtggt?acgtcgagcg?gcgccgggcg 80340
atcagatcgc?ggtcgacatc?gtccaggaag?aagaaccgct?ccagctcagg?gcgggtcggc 80400
tcctcggcga?acttcccgta?cgcctcggcc?tgctcatcag?tcagaaactc?caccggcacg 80460
agcggaccgt?agccagcccc?agcacccgcc?cggcgatctt?ccggcgaacc?ccagcggagc 80520
caccggcggg?tgtgctagct?gcccatgatc?aatctcagcg?ccaaccgctg?taccgatgtt 80580
ccccgaggcc?ggtctgcgcg?tacgcggcgg?tcgcgacccg?tacgcgctcc?ggcccgacga 80640
ggtccctcgc?gccggccagg?tagcggcggg?cccccaggac?cagccagtgg?aggatccccg 80700
gcccttcctc?gcgcaccagg?acgtcggcga?ggttgtcgat?ccgccggtcg?tcggggacga 80760
cgcggtcgaa?ggggatcagg?cgcatccggc?gccagaaggc?gaagccgccg?gtgccgacct 80820
cgggacggtg?gttgcccagc?agccacagct?tgtgcgtcgg?ctcgaagctg?aagaagtcct 80880
gccgcatccg?gcgcgccttg?atgcggtcac?cgccggtcag?cagcttcagg?cgggcctcgt 80940
cgaaccggtc?gccgggcctg?acctcgctgc?acacgatcac?ccggcgcccg?tgcagttccg 81000
ccaggtcggt?ggggtggccc?tcgtagggac?gcgccatcag?gtgttcctag?gctgtttcct 81060
g 81061
<210>2
<211>5476
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>2
Val?Asn?Pro?Leu?Phe?Pro?Glu?Arg?Thr?Arg?Gly?Pro?Val?Arg?Thr?Asp
1 5 10 15
Leu?Ile?Lys?Pro?Leu?Pro?Val?Ala?Leu?Leu?Glu?Asn?Ala?Val?Arg?Phe
20 25 30
Pro?Asp?Lys?Val?Ala?Phe?Ala?Asp?Asp?Arg?Arg?Ala?Val?Thr?Tyr?Gly
35 40 45
Asp?Leu?Glu?Ala?Arg?Thr?Arg?Arg?Leu?Ala?Gly?His?Leu?Ala?His?Leu
50 55 60
Gly?Val?Glu?Arg?Gly?Asp?Arg?Val?Ala?Leu?Cys?Leu?Gly?Asn?Thr?Val
65 70 75 80
Ser?Thr?Val?Glu?Ser?Tyr?Leu?Ala?Ile?Val?Arg?Ala?Gly?Gly?Val?Gly
85 90 95
Val?Pro?Leu?Asn?Pro?Ala?Ser?Ala?Pro?Ala?Glu?Leu?Asp?Tyr?Leu?Leu
100 105 110
Ala?Asp?Ser?Gly?Ala?Ala?Leu?Val?Ile?Thr?Asp?Thr?Ala?Arg?Ala?Arg
115 120 125
Asn?Phe?Arg?Gly?Gly?Pro?Gly?Glu?Leu?Pro?Asp?Thr?Val?Leu?Val?Leu
130 135 140
Thr?Gly?Gly?Ala?Pro?Arg?Asp?Leu?Pro?Gln?Gly?Pro?Gly?Val?His?Ala
145 150 155 160
Tyr?Glu?Glu?Leu?Ala?Arg?Gly?Glu?Pro?Pro?Val?Pro?Ala?Arg?Asp?Asp
165 170 175
Leu?Ala?Leu?Asp?Glu?Val?Ala?Trp?Met?Phe?Tyr?Thr?Ser?Gly?Thr?Thr
180 185 190
Gly?Arg?Pro?Lys?Gly?Val?Leu?Ser?Thr?Gln?Arg?Asn?Cys?Leu?Trp?Ser
195 200 205
Val?Ala?Ser?Ser?Tyr?Val?Pro?Ile?Pro?Gly?Leu?Thr?Asp?Arg?Asp?Arg
210 215 220
Val?Leu?Trp?Pro?Leu?Pro?Leu?Phe?His?Ser?Leu?Ser?His?Ile?Ala?Cys
225 230 235 240
Val?Leu?Ser?Val?Thr?Val?Ser?Gly?Ala?Thr?Ala?Arg?Leu?Met?Asp?Gly
245 250 255
Ser?Ser?Ala?Asp?Asp?Ile?Met?Arg?Val?Leu?Thr?Glu?Asp?Arg?Thr?Thr
260 265 270
Phe?Leu?Ala?Gly?Val?Pro?Thr?Thr?Tyr?His?His?Leu?Val?Thr?Ala?Ala
275 280 285
Arg?Asp?Asn?Gly?Phe?Ser?Ala?Pro?Asp?Leu?Arg?Ile?Gly?Leu?Val?Gly
290 295 300
Gly?Ala?Val?Thr?Gly?Ala?Gly?Leu?Arg?Arg?Asp?Val?Glu?Glu?Thr?Leu
305 310 315 320
Gly?Val?Pro?Leu?Val?Asp?Ala?Tyr?Gly?Ser?Thr?Glu?Thr?Cys?Gly?Ala
325 330 335
Ile?Thr?Met?Asn?Pro?Pro?Asp?Gly?Pro?Arg?Val?Asp?Gly?Ser?Cys?Gly
340 345 350
Leu?Pro?Val?Pro?Gly?Val?Asp?Val?Arg?Val?Val?Asp?Pro?Ala?Thr?Gly
355 360 365
Thr?Asp?Val?Pro?Thr?Gly?Ala?Asp?Gly?Glu?Val?Trp?Val?Ser?Gly?Pro
370 375 380
Asn?Val?Met?Val?Gly?Tyr?His?Asn?Ala?Pro?Asp?Ala?Thr?Ala?Glu?Ala
385 390 395 400
Leu?Arg?Asp?Gly?Trp?Phe?Arg?Thr?Gly?Asp?Leu?Ala?Arg?Arg?Asp?Asp
405 410 415
Ala?Gly?Tyr?Phe?Thr?Ile?Arg?Gly?Arg?Ile?Lys?Glu?Leu?Val?Ile?Arg
420 425 430
Gly?Gly?Glu?Asn?Ile?His?Pro?Glu?Glu?Val?Glu?Ala?Val?Leu?Arg?Thr
435 440 445
Val?Glu?Gly?Val?Ala?Asp?Ala?Ala?Val?Ala?Gly?Ala?Pro?His?Asp?Thr
450 455 460
Leu?Gly?Glu?Val?Pro?Val?Ala?Tyr?Val?Val?Pro?Gly?Pro?Thr?Gly?Tyr
465 470 475 480
Asp?Pro?Ala?Ala?Leu?Ile?Ala?Arg?Cys?Arg?Glu?Arg?Leu?Ser?Ala?Tyr
485 490 495
Lys?Val?Pro?Glu?Arg?Val?Arg?Glu?Val?Ala?Ser?Ile?Pro?Arg?Thr?Pro
500 505 510
Ser?Gly?Lys?Thr?Lys?Arg?Leu?Leu?Leu?Ala?Glu?Gln?Pro?Gly?Arg?Leu
515 520 525
Arg?Tyr?Ala?Ala?Ser?Gly?His?His?Asp?Ala?Leu?Thr?Arg?Val?Glu?Trp
530 535 540
Val?Thr?Ala?Pro?Ala?Pro?Ala?Thr?Ala?Pro?Pro?Ala?Gly?Thr?Arg?Trp
545 550 555 560
Ala?Val?Ala?Gly?Pro?Ala?Ala?Gly?Leu?Val?Thr?Val?Leu?Glu?Ala?Ala
565 570 575
Gly?Ala?Gln?Val?Arg?His?Tyr?Ala?Asp?Leu?Ala?Ala?Ala?Arg?Ala?Ala
580 585 590
Val?Thr?Asp?Gly?Asp?Pro?Ala?Pro?Asp?Val?Thr?Leu?Leu?Val?Pro?Pro
595 600 605
Ala?Ala?Ser?Ala?Gly?Glu?Ala?Val?Gly?Gly?Arg?Asp?Gly?Glu?Ser?Ala
610 615 620
Gly?Gly?Arg?Gly?Thr?Asp?Ala?Val?Ser?Ala?Gly?Arg?Glu?Arg?Ala?Arg
625 630 635 640
Trp?Leu?Ala?Arg?Glu?Val?Glu?Ala?Trp?Thr?Ala?Leu?Pro?Gly?Ala?Ala
645 650 655
His?Gly?Lys?Leu?Val?Leu?Leu?Thr?Pro?Gly?Ala?Val?Ala?Ala?Thr?Gly
660 665 670
Thr?Asp?Pro?Ala?Gln?Asp?Leu?Ala?Glu?Ala?Ala?Leu?Trp?Gly?Ala?Ala
675 680 685
Arg?Ala?Leu?Gln?Gln?Thr?Arg?Pro?Glu?Gly?Leu?Thr?Val?Leu?Asp?Val
690 695 700
Leu?Asp?Gly?Pro?Asp?Pro?Ser?Pro?Asp?Thr?Leu?Ser?Ser?Asp?Thr?Leu
705 710 715 720
Ser?Ser?Asp?Thr?Leu?Ser?Ala?Asp?Thr?Leu?Ser?Ala?Val?Leu?Ala?Ser
725 730 735
Asp?Glu?Pro?Gln?Ile?Ala?Val?Arg?Ser?Ala?Ala?Leu?Leu?Val?Pro?Arg
740 745 750
Leu?Thr?Pro?Leu?Pro?Val?Thr?Asp?Arg?Pro?Gln?Lys?Gly?Phe?Gly?Ser
755 760 765
Glu?Ala?Thr?Gly?Thr?Val?Leu?Val?Thr?Gly?Ala?Asp?Thr?Glu?His?Gly
770 775 780
Ala?Ala?Leu?Ala?His?Arg?Leu?Ala?Thr?Ala?His?Arg?Ala?Thr?Ser?Leu
785 790 795 800
Leu?Leu?Val?Gly?Ala?Pro?Gly?Ser?Pro?Asp?Ala?Thr?Pro?Gly?Asp?Ala
805 810 815
Leu?Ala?Leu?Pro?Gly?Thr?Ser?Val?Val?Arg?Val?Thr?Ala?Asp?Thr?Ala
820 825 830
His?Leu?Gly?Pro?Leu?Arg?Ala?Ala?Leu?Thr?Asp?Leu?Thr?Asp?Leu?Gly
835 840 845
Gln?Pro?Val?His?Ala?Val?Val?Asp?Ala?Ala?Gly?Asp?Pro?Ala?Leu?Thr
850 855 860
Arg?Cys?Leu?Asp?Gln?Met?Thr?Ala?Gly?Asn?Asp?Leu?Thr?Ala?Phe?Val
865 870 875 880
Val?Val?Thr?Pro?Gly?Ala?Ala?Gly?Leu?Pro?Gly?Ser?Ser?Asp?Asp?Pro
885 890 895
Ala?Ala?Asn?Leu?Asp?Gly?Thr?Leu?Cys?Glu?Ala?Val?Val?Arg?Asn?Arg
900 905 910
Arg?Leu?Arg?Asn?Gln?Pro?Gly?Ser?Phe?Leu?Thr?Trp?Asn?Gly?Arg?Leu
915 920 925
Thr?Asp?Pro?Gly?Ala?Gly?Pro?Leu?Arg?Gln?Glu?Leu?Leu?Ala?Ala?Phe
930 935 940
Asp?Ile?Ala?Leu?Thr?Thr?Asp?Pro?Gln?Ala?Pro?Leu?Ala?Val?Leu?Pro
945 950 955 960
Thr?Arg?Ala?Thr?Gly?Arg?Gly?Arg?Val?Pro?Ala?Leu?Leu?Arg?Ala?Leu
965 970 975
Val?Arg?Pro?Pro?Ala?Arg?Asp?Gly?Glu?Pro?Asp?Ser?Ala?Arg?Thr?Val
980 985 990
Ser?Leu?Arg?Ala?Glu?Leu?Ser?Ala Met?Asp?Asp?Arg?Asp Arg?Arg?Thr
995 1000 1005
His?Leu Glu?Asn?Leu?Val?Arg Thr?Leu?Ala?Ala?Asp Val?Leu?His
1010 1015 1020
Leu?Ala Asp?Ala?Ala?Leu?Ile Pro?Ala?Asp?Arg?Ala Phe?Arg?Asp
1025 1030 1035
Leu?Gly Phe?Thr?Ser?Leu?Ala Val?Val?Ala?Leu?Arg Asn?Arg?Leu
1040 1045 1050
Thr?Glu Arg?Thr?Gly?Leu?Arg Leu?Pro?Thr?Thr?Ile Ala?Phe?Asp
1055 1060 1065
His?Pro Thr?Pro?Ala?Asp?Leu Ala?Ala?Tyr?Leu?Arg Ser?Glu?Ile
1070 1075 1080
Leu?Gly Asp?Ser?Ala?Pro?Ala Ala?Ala?Thr?Asn?Pro Ala?Val?Asp
1085 1090 1095
Pro?Val Glu?Ser?Val?Asp?Pro Ala?Asp?Pro?Val?Ala Ile?Val?Gly
1100 1105 1110
Met?Ala Cys?Arg?Leu?Pro?Gly Gly?Val?Ala?Ser?Pro Glu?Gln?Leu
1115 1120 1125
Trp?Lys Leu?Val?Ala?Glu?Gly Val?Asp?Ala?Val?Ser Asp?Phe?Pro
1130 1135 1140
Gly?Asp Arg?Gly?Trp?Asp?Leu Gly?Arg?Leu?Phe?Asp Pro?Glu?His
1145 1150 1155
Pro?Asp Arg?Ala?Gly?Thr?Ser Cys?Thr?Asn?Gln?Gly Gly?Phe?Leu
1160 1165 1170
Glu?Gly Ala?Gly?Leu?Phe?Asp Ala?Gly?Phe?Phe?Gly Ile?Ser?Pro
1175 1180 1185
Arg?Glu Ala?Leu?Ala?Met?Asp Pro?Gln?Gln?Arg?Leu Leu?Leu?Glu
1190 1195 1200
Thr?Ser Trp?Glu?Ala?Leu?Glu Arg?Ala?Gly?Ile?Asp Pro?Val?Thr
1205 1210 1215
Leu?Lys Gly?Ala?Asp?Val?Gly Val?Phe?Ser?Gly?Leu Phe?Gly?Gln
1220 1225 1230
Gly?Tyr Gly?Thr?Gly?Ala?Val Pro?Pro?Glu?Leu?Glu Gly?Phe?Ala
1235 1240 1245
Ser?Thr Gly?Leu?Ala?Ser?Ser Val?Ala?Ser?Gly?Arg Val?Ser?Tyr
1250 1255 1260
Val?Phe Gly?Phe?Glu?Gly?Pro Ala?Val?Ser?Val?Asp Thr?Ala?Cys
1265 1270 1275
Ser?Ser Ser?Leu?Val?Ala?Met His?Leu?Ala?Ala?Gln Ala?Leu?Arg
1280 1285 1290
Gln?Gly Glu?Cys?Ser?Met?Ala Leu?Ala?Gly?Gly?Val Ala?Val?Met
1295 1300 1305
Ala?Thr Pro?Asp?Asn?Phe?Val Glu?Phe?Ser?Arg?Gln Arg?Ala?Leu
1310 1315 1320
Ser?Ala Asp?Gly?Arg?Cys?Lys Ala?Phe?Ser?Ser?Thr Ala?Asp?Gly
1325 1330 1335
Thr?Gly Trp?Ala?Glu?Gly?Val Gly?Val?Val?Val?Leu Glu?Arg?Leu
1340 1345 1350
Ser?Val Ala?Arg?Glu?Arg?Gly His?Arg?Val?Leu?Ala Val?Leu?Arg
1355 1360 1365
Gly?Ser Ala?Val?Asn?Gln?Asp Gly?Ala?Ser?Asn?Gly Leu?Thr?Ala
1370 1375 1380
Pro?Asn Gly?Leu?Ser?Gln?Gln Arg?Val?Ile?Arg?Arg Ala?Leu?Ser
1385 1390 1395
Ser?Ala Gly?Leu?Ser?Ala?Ala Asp?Val?Asp?Val?Val Glu?Ala?His
1400 1405 1410
Gly?Thr Gly?Thr?Ala?Leu?Gly Asp?Pro?Ile?Glu?Ala Gln?Ala?Leu
1415 1420 1425
Leu?Ala Thr?Tyr?Gly?Lys?Gly Arg?Asp?Ala?Gly?Arg Pro?Leu?Trp
1430 1435 1440
Leu?Gly Ser?Leu?Lys?Ser?Asn Val?Gly?His?Thr?Gln Ala?Ala?Ala
1445 1450 1455
Gly?Val Ala?Gly?Val?Ile?Lys Met?Val?Gln?Ala?Leu Arg?His?Gly
1460 1465 1470
Val?Met Pro?Ala?Thr?Leu?His Val?Asp?Ala?Pro?Thr Ser?Arg?Val
1475 1480 1485
Asp?Trp Ser?Ala?Gly?Ala?Val Glu?Leu?Leu?Thr?Glu Ala?Arg?Glu
1490 1495 1500
Trp?Pro Arg?Glu?Asp?Arg?Pro Arg?Arg?Ala?Gly?Val Ser?Ala?Phe
1505 1510 1515
Gly?Val Ser?Gly?Thr?Asn?Ala His?Leu?Ile?Leu?Glu Glu?Ala?Pro
1520 1525 1530
Glu?Glu Val?Ala?Ala?Pro?Pro Val?Ser?Ser?Ala?Gly Val?Val?Pro
1535 1540 1545
Leu?Val Val?Ser?Ala?Arg?Ser Ala?Gly?Ser?Leu?Ala Gly?Gln?Ala
1550 1555 1560
Gly?Arg Leu?Ala?Ala?Phe?Val Glu?Glu?Ser?Asp?Gly Val?Pro?Leu
1565 1570 1575
Ala?Ser Val?Ala?Gly?Ala?Leu Val?Ala?Gly?Arg?Ala Val?Leu?Gly
1580 1585 1590
Glu?Arg Ala?Val?Val?Val?Ala Glu?Ser?Gly?Ala?Glu Ala?Leu?Ala
1595 1600 1605
Gly?Leu Arg?Ser?Phe?Ala?Lys Gly?Glu?Ser?Ala?Pro Gly?Val?Val
1610 1615 1620
Ser?Gly Ser?Ala?Gly?Ser?Gly Ala?Leu?Gly?Lys?Val Val?Trp?Val
1625 1630 1635
Phe?Pro Gly?Gln?Gly?Ser?Gln Trp?Ala?Gly?Met?Gly Arg?Glu?Leu
1640 1645 1650
Ile?Asp Ala?Ser?Pro?Val?Phe Ala?Glu?Arg?Ile?Ala Glu?Cys?Ala
1655 1660 1665
Ala?Ala Leu?Glu?Pro?Trp?Ile Asp?Trp?Ser?Leu?Val Glu?Val?Leu
1670 1675 1680
Arg?Gly Glu?Val?Glu?Pro?Ala Leu?Leu?Glu?Arg?Val Asp?Val?Leu
1685 1690 1695
Gln?Pro Ala?Ser?Phe?Ala?Val Met?Val?Gly?Leu?Ala Ala?Val?Trp
1700 1705 1710
Ala?Ser Val?Gly?Val?Glu?Pro Asp?Ala?Val?Val?Gly His?Ser?Gln
1715 1720 1725
Gly?Glu Ile?Ala?Ala?Ala?Cys Val?Ser?Gly?Ala?Leu Ser?Leu?Glu
1730 1735 1740
Asp?Ala Ala?Arg?Val?Val?Ala Leu?Arg?Ser?Gln?Ala Ile?Ala?Gly
1745 1750 1755
Gln?Leu Ala?Gly?Arg?Gly?Gly Met?Ala?Ser?Val?Ala Leu?Ser?Glu
1760 1765 1770
Ala?Asp Ala?Val?Ala?Arg?Leu Glu?Arg?Trp?Ala?Asp Arg?Val?Glu
1775 1780 1785
Val?Ala Ala?Val?Asn?Gly?Pro Ser?Ser?Val?Val?Val Ala?Gly?Asp
1790 1795 1800
Ala?Glu Ala?Leu?Asp?Glu?Ala Leu?Glu?Asp?Leu?Ser Ala?Asp?Gly
1805 1810 1815
Val?Arg Val?Arg?Arg?Val?Ala Val?Asp?Tyr?Ala?Ser His?Thr?Arg
1820 1825 1830
His?Val Glu?Asp?Ile?Arg?Glu Thr?Leu?Val?Glu?Thr Leu?Ala?Gly
1835 1840 1845
Val?Asn Ala?Gln?Ala?Pro?Ser Ile?Pro?Phe?Tyr?Ser Thr?Val?Thr
1850 1855 1860
Gly?Glu Trp?Val?Asp?Gln?Ala Gly?Val?Leu?Asp?Gly Ala?Tyr?Trp
1865 1870 1875
Tyr?Arg Asn?Leu?Arg?Gly?Gln Val?Gly?Phe?Gly?Pro Ala?Val?Thr
1880 1885 1890
Asp?Leu Val?Ser?Gln?Gly?His Arg?Thr?Phe?Val?Glu Val?Ser?Ala
1895 1900 1905
His?Pro Val?Leu?Val?Gln?Pro Val?Thr?Glu?Thr?Val Tyr?Ala?Ala
1910 1915 1920
Gly?Val Asp?Thr?Glu?Ala?Leu Val?Thr?Gly?Ser?Leu Arg?Arg?Asp
1925 1930 1935
Asp?Gly Gly?Leu?Arg?Arg?Leu Leu?Ala?Ser?Met?Ala Glu?Leu?Phe
1940 1945 1950
Val?Arg Gly?Val?Thr?Val?Asp Trp?Thr?Gly?Val?Leu Pro?Ala?Gly
1955 1960 1965
Ala?Thr Ser?Ala?Arg?Leu?Asp Leu?Pro?Thr?Tyr?Ala Phe?Asp?His
1970 1975 1980
Gln?His Tyr?Trp?Leu?Gln?Ala Thr?Asp?Ala?Gly?Pro Val?Asp?Ala
1985 1990 1995
Ala?Ser Leu?Gly?Leu?Ala?Gly Ser?Asp?His?Pro?Leu Leu?Gly?Ala
2000 2005 2010
Val?Val Gly?Met?Pro?Asn?Ser Gly?Gly?Leu?Val?Ala Thr?Ser?Arg
2015 2020 2025
Trp?Ser Pro?Gly?Ala?His?Pro Trp?Leu?Ala?Asp?Gln Val?Val?Ala
2030 2035 2040
Asp?Ala Val?Val?Val?Pro?Asn Ala?Ala?Leu?Val?Glu Leu?Ala?Ile
2045 2050 2055
Arg?Leu Gly?Asp?Leu?Ala?Ala Val?Pro?Val?Ile?Asp Glu?Leu?Thr
2060 2065 2070
Val?Asp Thr?Pro?Val?Val?Leu Pro?Gln?Gly?Gly?Asp Arg?Ser?Ile
2075 2080 2085
Gln?Val Val?Val?Gly?Glu?Ser Asp?Gly?Ala?Arg?Arg Pro?Val?Glu
2090 2095 2100
Val?Tyr Ser?Arg?Ala?Ala?Asp Ala?Pro?Leu?Asp?Ala Glu?Trp?Val
2105 2110 2115
Arg?His Ala?His?Gly?Thr?Leu Val?Pro?Ala?Asp?Gly Arg?Glu?Thr
2120 2125 2130
Pro?Ala Val?Ala?Gly?Pro?Asp Gly?Glu?Ser?Ala?Glu Val?His?Leu
2135 2140 2145
Asp?Gly Ala?Ala?Leu?Arg?Asp Ala?Glu?Arg?Tyr?Gly Val?His?Pro
2150 2155 2160
Ala?Leu Leu?Asp?Ala?Ala?Val Arg?Thr?Val?Val?Pro Ser?Gly?Met
2165 2170 2175
Val?Pro Ser?Val?Trp?Ser?Gly Val?Ala?Leu?His?Ala Ser?Gly?Ala
2180 2185 2190
Thr?Ala Leu?His?Val?Arg?Arg Asp?Ala?Ala?Pro?Asp Gln?Asp?Ala
2195 2200 2205
Arg?Leu Leu?Leu?Thr?Asp?Pro Ala?Gly?Arg?Pro?Val Met?Thr?Val
2210 2215 2220
Glu?Gly Val?Arg?Ala?Ala?Pro Phe?Ser?Pro?Glu?Arg Ala?Gly?Ile
2225 2230 2235
Ala?Gly Ala?Leu?Pro?His?Asp Ala?Leu?Phe?Arg?Val Asp?Trp?Thr
2240 2245 2250
Pro?Leu Ser?Pro?Ala?Thr?Val Asp?Arg?Ala?Pro?Val Asp?Val?Pro
2255 2260 2265
Val?Gly Asp?Gly?Ala?Asp?Val Ala?Ala?Ala?Val?Ala Gly?Asp?Gly
2270 2275 2280
Ala?Ala Pro?Asp?Leu?Leu?Val Tyr?Asp?Val?Arg?Gly Gly?Ser?Ala
2285 2290 2295
Ala?Gly Asp?Pro?Arg?Glu?Asp Ala?Gly?Ala?Ala?Leu Ala?Val?Leu
2300 2305 2310
Gln?Ala Trp?Leu?Ala?Ala?Pro Ala?Pro?Glu?Gly?Ala Arg?Leu?Ala
2315 2320 2325
Val?Val Thr?Gly?Asp?Cys?Asp Glu?Leu?Gly?Ala?Ala Ala?Val?Trp
2330 2335 2340
Gly?Leu Val?Arg?Ser?Ala?Gln Ser?Glu?His?Pro?Asp Arg?Val?Val
2345 2350 2355
Leu?Val Asp?Val?Asp?Asp?Asp Pro?Arg?Pro?Ala?Leu His?Asp?Ser
2360 2365 2370
Ala?Ser Ala?Leu?Thr?Ala?Ala Val?Leu?Ser?Gly?Glu Pro?Gln?Leu
2375 2380 2385
Arg?Val Arg?Gly?Gly?Val?Ala Ser?Val?Pro?Arg?Leu Val?Arg?Val
2390 2395 2400
Arg?Gly Ala?Ala?Pro?Glu?Ala Val?Pro?Pro?Ala?Arg Pro?Leu?Asp
2405 2410 2415
Pro?Glu Gly?Thr?Val?Leu?Ile Thr?Gly?Gly?Thr?Gly Thr?Leu?Gly
2420 2425 2430
Ala?Leu Thr?Ala?Arg?His?Leu Val?Thr?Ala?Tyr?Gly Val?Arg?His
2435 2440 2445
Leu?Val Leu?Ala?Ser?Arg?Ser Gly?Gly?Ala?Pro?His Leu?Arg?Glu
2450 2455 2460
Glu?Leu Thr?Glu?Leu?Gly?Ala Thr?Val?Thr?Val?Thr Ala?Cys?Asp
2465 2470 2475
Val?Ser Asp?Arg?Gly?Gln?Val Glu?Ala?Leu?Leu?Arg Ala?Ile?Pro
2480 2485 2490
Ala?Gly His?Pro?Leu?Thr?Ala Val?Val?His?Thr?Ala Gly?Val?Leu
2495 2500 2505
Asp?Asp Gly?Val?Leu?Thr?Glu Gln?Thr?Pro?Gln?Arg Ile?Asp?Thr
2510 2515 2520
Val?Leu Arg?Pro?Lys?Leu?Asp Ala?Ala?Arg?His?Leu Asp?Glu?Leu
2525 2530 2535
Thr?Arg Asp?Leu?Asp?Leu?Ala Ala?Phe?Val?Leu?Phe Ser?Ser?Ala
2540 2545 2550
Ala?Gly Ile?Leu?Gly?Asn?Pro Gly?Gln?Ala?Asn?Tyr Ala?Ala?Ala
2555 2560 2565
Asn?Ala Cys?Leu?Asp?Ala?Val Ala?Arg?Gln?Arg?His Arg?Leu?Gly
2570 2575 2580
Leu?Pro Ala?Val?Ser?Leu?Ala Trp?Gly?Tyr?Trp?Ser Thr?Val?Ser
2585 2590 2595
Ala?Met Thr?Glu?His?Leu?Asp Ala?Ala?Asp?Leu?Arg Arg?Asn?Arg
2600 2605 2610
Arg?Ile Gly?Met?Ala?Gly?Leu Thr?Ala?Ala?Glu?Gly Met?Ala?Leu
2615 2620 2625
Leu?Asp Ala?Ala?Leu?Ser?Gly Ala?Ala?Asp?Ala?Asp Gly?Ala?Leu
2630 2635 2640
Leu?Ala Ala?Lys?Phe?Asp?Leu Ser?Val?Leu?Arg?Ala Ala?Ala?Ala
2645 2650 2655
Asp?Gly Pro?Leu?Pro?Ala?Pro Leu?Arg?Gly?Leu?Ala Pro?Ala?Pro
2660 2665 2670
Arg?Pro Val?Ala?Gly?Thr?Ala Thr?Arg?Ser?Ala?Arg Gly?Ser?Leu
2675 2680 2685
Ala?Glu Arg?Leu?Ala?Gly?Leu Asp?Asp?Thr?Glu?Gln Glu?Glu?Ala
2690 2695 2700
Leu?Val Asp?Leu?Val?Arg?Arg His?Ala?Ala?Glu?Val Leu?Gly?His
2705 2710 2715
Gly?Thr Ala?Asp?Ala?Ile?Arg Ala?Asp?Arg?Pro?Phe Lys?Asp?Ala
2720 2725 2730
Gly?Phe Asp?Ser?Leu?Thr?Ala Val?Glu?Leu?Arg?Asn Arg?Leu?Val
2735 2740 2745
Ala?Ala Thr?Gly?Leu?Thr?Leu Ser?Pro?Ala?Leu?Ile Phe?Asp?Tyr
2750 2755 2760
Pro?Lys Pro?Ala?Thr?Leu?Ala Glu?His?Leu?Arg?Gly Arg?Leu?Val
2765 2770 2775
Gly?Gly Ala?Ala?Pro?Arg?Thr Ala?Gly?Thr?Thr?Asp Pro?Ala?Ala
2780 2785 2790
Ser?Val Pro?Ala?Val?Pro?Ala Val?Pro?Glu?Pro?Gly Asp?Glu?Pro
2795 2800 2805
Ile?Ala Ile?Val?Gly?Met?Ala Cys?Arg?Phe?Pro?Ala Gly?Val?His
2810 2815 2820
Ser?Pro Glu?Asp?Leu?Trp?Arg Val?Val?Ala?Asp?Gly Val?Asp?Val
2825 2830 2835
Val?Thr Glu?Phe?Pro?Asp?Asp Arg?Gly?Trp?Asp?Thr Asp?Arg?Ile
2840 2845 2850
Phe?His Pro?Asp?Pro?Asp?His Ala?Gly?Thr?Thr?Tyr Val?Arg?His
2855 2860 2865
Gly?Ala Phe?Leu?Asp?Asp?Ala Ala?Gly?Phe?Asp?Ala Ala?Phe?Phe
2870 2875 2880
Gly?Ile Ser?Pro?Asn?Glu?Ala Leu?Ala?Met?Asp?Pro Gln?Gln?Arg
2885 2890 2895
Leu?Leu Leu?Glu?Thr?Ser?Trp Glu?Ala?Phe?Glu?Arg Ala?Ala?Ile
2900 2905 2910
Asp?Pro Thr?Thr?Leu?A1a?Gly Gln?Asp?Val?Gly?Val Tyr?Val?Gly
2915 2920 2925
Val?Asn Ser?His?Asp?Tyr?Ser Val?Arg?Thr?His?Gln Ala?Ala?Gly
2930 2935 2940
Val?Glu Gly?Phe?Arg?Leu?Thr Gly?Ser?Ser?Gly?Ala Val?Thr?Ser
2945 2950 2955
Gly?Arg Val?Ala?Tyr?His?Leu Gly?Thr?Glu?Gly?Pro Ala?Ile?Thr
2960 2965 2970
Val?Asp Thr?Ala?Cys?Ser?Ser Ser?Leu?Val?Ala?Leu His?Leu?Ala
2975 2980 2985
Ala?Gln Ala?Leu?Asn?Arg?Gly Glu?Cys?Thr?Met?Ala Leu?Ala?Gly
2990 2995 3000
Gly?Val Met?Val?Met?Gly?Thr Val?Glu?Thr?Phe?Val Glu?Phe?Ser
3005 3010 3015
Arg?Gln Arg?Gly?Leu?Ala?Pro Asp?Gly?Arg?Cys?Lys Ala?Phe?Ala
3020 3025 3030
Asp?Gly Ala?Asp?Gly?Thr?Gly Trp?Ser?Glu?Gly?Ala Gly?Leu?Leu
3035 3040 3045
Leu?Val Glu?Arg?Leu?Ser?Asp Ala?Arg?Arg?Asn?Gly His?Arg?Val
3050 3055 3060
Leu?Ala Val?Val?Arg?Gly?Thr Ala?Val?Asn?Gln?Asp Gly?Ala?Ser
3065 3070 3075
Asn?Gly Leu?Thr?Ala?Pro?Asn Gly?Pro?Ser?Gln?Gln Arg?Val?Ile
3080 3085 3090
Arg?Arg Ala?Leu?Ala?Asp?Ala Gly?Leu?Arg?Thr?Ser Asp?Val?Asp
3095 3100 3105
Ala?Val Glu?Ala?His?Gly?Thr Gly?Thr?Thr?Leu?Gly Asp?Pro?Ile
3110 3115 3120
Glu?Ala Glu?Ala?Leu?Leu?Ala Thr?Tyr?Gly?Gln?Asp Arg?Pro?Ala
3125 3130 3135
Gly?Arg Pro?Leu?Trp?Leu?Gly Ser?Val?Lys?Ser?Asn Ile?Gly?His
3140 3145 3150
Thr?Gln Ala?Ala?Ala?Gly?Val Ala?Gly?Val?Ile?Lys Met?Val?Met
3155 3160 3165
Ala?Met Arg?His?Gly?Val?Leu Pro?Arg?Thr?Leu?His Val?Asp?Arg
3170 3175 3180
Pro?Ser Thr?His?Val?Asp?Trp Ser?Ala?Gly?Ala?Val Glu?Leu?Leu
3185 3190 3195
Thr?Glu Ala?Arg?Glu?Trp?Pro Arg?Glu?Gly?Arg?Pro Arg?Arg?Thr
3200 3205 3210
Gly?Val Ser?Ser?Phe?Gly?Ile Gly?Gly?Thr?Asn?Ala His?Val?Ile
3215 3220 3225
Leu?Glu Glu?Ala?Pro?Gly?Val Leu?Glu?Glu?Ala?Pro Gly?Ile?His
3230 3235 3240
Glu?Ala Ala?Pro?Gly?Val?Pro Ala?Pro?Ala?Pro?Val Pro?Gly?Pro
3245 3250 3255
Val?Leu Val?Pro?Val?Ser?Gly Arg?Thr?Pro?Ala?Gly Leu?Arg?Gly
3260 3265 3270
Gln?Ala Asp?Arg?Leu?Ala?Arg Phe?Leu?Asp?Glu?Arg Pro?Gly?Thr
3275 3280 3285
Pro?Leu Thr?Asp?Thr?Ala?His Ala?Leu?Ala?Thr?Thr Arg?Ala?Arg
3290 3295 3300
Leu?Asp His?Arg?Ala?Val?Val Leu?Ala?Ser?Asp?Arg Gln?Gln?Leu
3305 3310 3315
His?Ala Asp?Leu?Thr?Ser?Leu Ala?Gln?Gly?Gly?Thr Pro?Pro?Thr
3320 3325 3330
Ala?Val Thr?Gly?Thr?Pro?Ala Thr?Gly?Lys?Leu?Ala Val?Leu?Phe
3335 3340 3345
Thr?Gly Gln?Gly?Ser?Gln?Trp Ala?Gly?Met?Gly?Arg Glu?Leu?Ala
3350 3355 3360
Ala?Gly Phe?Pro?Val?Phe?Arg Gln?Ala?Phe?Asp?Ala Ala?Cys?Asp
3365 3370 3375
Ala?Val Asp?Ala?His?Leu?Arg Gly?His?Ala?Ala?Leu Pro?Leu?Arg
3380 3385 3390
Glu?Val Val?Leu?Ala?Thr?Pro Gly?Thr?Pro?Gly?Ser Ala?Leu?Leu
3395 3400 3405
Asp?Arg Thr?Met?Tyr?Thr?Gln Gly?Ala?Leu?Phe?Ala Leu?Glu?Thr
3410 3415 3420
Ala?Leu Tyr?Arg?Leu?Phe?Ala Ser?Trp?Gly?Ile?Arg Pro?Asp?Leu
3425 3430 3435
Leu?Ala Gly?His?Ser?Val?Gly Glu?Ile?Thr?Ala?Ala His?Val?Ser
3440 3445 3450
Gly?Val Leu?Ala?Leu?Glu?Asp Ala?Ala?Glu?Leu?Val Ala?Ala?Arg
3455 3460 3465
Gly?Arg Leu?Met?Gln?Ala?Leu Pro?Glu?Gly?Gly?Ala Met?Val?Ala
3470 3475 3480
Val?Lys Ala?Thr?Glu?Ala?Asp Leu?Ala?Pro?Leu?Leu Ala?Arg?Ala
3485 3490 3495
His?Gly Val?Val?Cys?Val?Ala Ala?Val?Asn?Gly?Pro Asp?Ala?Leu
3500 3505 3510
Val?Leu Ser?Gly?Thr?Glu?Asp Ala?Val?Leu?Ala?Val Ala?Gly?Glu
3515 3520 3525
Leu?Ala Arg?Arg?Gly?His?Lys Thr?His?Arg?Leu?Thr Val?Ser?His
3530 3535 3540
Ala?Phe His?Ser?Ser?Leu?Met Glu?Pro?Met?Leu?Glu Glu?Phe?Arg
3545 3550 3555
Thr?Val Ala?Glu?Arg?Leu?Ser Tyr?Gln?Pro?Gly?Ala Leu?Arg?Val
3560 3565 3570
Val?Ser Thr?Val?Thr?Gly?Glu Pro?Ala?Thr?Asp?Gly Gln?Leu?Ala
3575 3580 3585
Thr?Pro Gly?Tyr?Trp?Val?Asp Gln?Ala?Arg?Ala?Pro Val?Arg?Phe
3590 3595 3600
Gly?Asp Ala?Leu?Ala?Ala?Leu Gly?Ala?Gln?Gly?Ala Thr?Thr?Phe
3605 3610 3615
Leu?Glu Leu?Gly?Pro?Gly?Ala Val?Leu?Thr?Ala?Leu Ala?Leu?Gly
3620 3625 3630
Ser?Pro Gly?Val?Gln?Glu?Gln Gly?Cys?Val?Ala?Thr Leu?Arg?Lys
3635 3640 3645
Asp?Gly Thr?Glu?Pro?Ala?Asp Val?Leu?Thr?Ala?Leu Ala?His?Leu
3650 3655 3660
His?Val Arg?Gly?Val?Pro?Leu Asp?Trp?Pro?Ala?Val Leu?Gly?Arg
3665 3670 3675
Thr?Thr Pro?Ala?Thr?Ala?Thr Gly?Thr?Glu?Leu?Pro Thr?Tyr?Ala
3680 3685 3690
Phe?Gln His?Arg?Arg?Tyr?Trp Val?Asp?Thr?Ala?Ala Thr?Pro?Asp
3695 3700 3705
Asp?Thr Gly?Thr?Pro?Gly?Thr Ala?Gly?Ala?Arg?His Thr?Leu?Pro
3710 3715 3720
Pro?Asp Thr?Ser?Val?His?Pro Ala?Ala?Gly?Ser?Gly Ala?Thr?Asp
3725 3730 3735
Glu?Ala Phe?Ala?Gly?Arg?Leu Ala?Gly?Leu?Pro?Ala Gln?Glu?Gln
3740 3745 3750
His?Arg Ala?Val?Thr?Asp?Leu Val?Lys?Glu?Ser?Val Ala?Val?Val
3755 3760 3765
Leu?Gly His?Arg?Asp?Pro?Asp Ala?Phe?Asp?Trp?Asn Ala?Gln?Gln
3770 3775 3780
Ser?Phe Lys?Ser?Leu?Gly?Phe Asp?Ser?Leu?Gly?Ala Val?Lys?Leu
3785 3790 3795
Arg?Asn Arg?Leu?Arg?Asp?Leu Thr?Gly?Val?Glu?Leu Pro?Ala?Thr
3800 3805 3810
Leu?Val Phe?Asp?Tyr?Pro?Thr Pro?Glu?Thr?Leu?Val Gly?His?Leu
3815 3820 3825
Arg?Ala Glu?Leu?Leu?Gly?Glu Gln?Pro?Gln?Thr?Pro Ser?Thr?Pro
3830 3835 3840
Val?Ala Gly?Pro?Ala?Pro?Ala Thr?Asp?Glu?Pro?Leu Ala?Ile?Val
3845 3850 3855
Ala?Met Ser?Thr?Arg?Leu?Pro Gly?Gly?Val?Asp?Ser Pro?Glu?Ala
3860 3865 3870
Leu?Trp Glu?Leu?Val?Thr?Glu Arg?Arg?Asp?Ala?Ile Ser?Gly?Phe
3875 3880 3885
Pro?Val Asp?Arg?Asp?Trp?Asp Leu?Asp?Gly?Leu?Tyr His?Pro?Asp
3890 3895 3900
Pro?Asp His?Pro?Gly?Thr?Ser Tyr?Thr?Arg?Ser?Gly Gly?Phe?Leu
3905 3910 3915
His?Asp Ala?Ala?Gln?Phe?Asp Ala?Ala?Leu?Phe?Gly Ile?Ser?Pro
3920 3925 3930
Arg?Glu Ala?Leu?Ala?Met?Asp Pro?Gln?Gln?Arg?Leu Leu?Leu?Glu
3935 3940 3945
Thr?Ser Trp?Glu?Ala?Leu?Glu Arg?Ala?Gly?Ile?Asp Pro?Leu?Ser
3950 3955 3960
Thr?Arg Gly?Ser?Asp?Ile?Gly Val?Phe?Thr?Gly?Ile Val?His?His
3965 3970 3975
Asp?Tyr Val?Thr?Arg?Leu?Arg Gln?Val?Pro?Glu?Asp Val?Gln?Gly
3980 3985 3990
Tyr?Leu Met?Thr?Gly?Thr?Ala Ala?Ser?Val?Ala?Ser Gly?Arg?Val
3995 4000 4005
Ser?Tyr Val?Phe?Gly?Phe?Glu Gly?Pro?Ala?Val?Thr Val?Asp?Thr
4010 4015 4020
Ala?Cys Ser?Ser?Ser?Leu?Val Ala?Met?His?Leu?Ala Ala?Gln?Ala
4025 4030 4035
Leu?Arg Gln?Gly?Glu?Cys?Ser Met?Ala?Leu?Ala?Gly Gly?Ala?Thr
4040 4045 4050
Val?Met Ala?Ser?Pro?Asp?Ala Phe?Met?Glu?Phe?Ser Arg?Gln?Arg
4055 4060 4065
Gly?Leu Ser?Ala?Asp?Gly?Arg Cys?Lys?Ala?Phe?Ser Ser?Thr?Ala
4070 4075 4080
Asp?Gly Thr?Gly?Trp?Ala?Glu Gly?Val?Gly?Val?Val Val?Leu?Glu
4085 4090 4095
Arg?Leu Ser?Val?Ala?Arg?Glu Arg?Gly?His?Lys?Val Leu?Ala?Val
4100 4105 4110
Leu?Arg Gly?Ser?Ala?Val?Asn Gln?Asp?Gly?Ala?Ser Asn?Gly?Leu
4115 4120 4125
Thr?Ala Pro?Asn?Gly?Pro?Ser Gln?Gln?Arg?Val?Ile Arg?Arg?Ala
4130 4135 4140
Leu?Ala Ser?Ala?Gly?Leu?Ser Ala?Ala?Asp?Val?Asp Val?Val?Glu
4145 4150 4155
Ala?His Gly?Thr?Gly?Thr?Ala Leu?Gly?Asp?Pro?Ile Glu?Ala?Gln
4160 4165 4170
Ala?Leu Leu?Ala?Thr?Tyr?Gly Lys?Glu?Arg?Asp?Ala Glu?Arg?Pro
4175 4180 4185
Leu?Trp Leu?Gly?Ser?Leu?Lys Ser?Asn?Ile?Gly?His Ala?Gln?Ala
4190 4195 4200
Ala?Ala Gly?Val?Ala?Gly?Val Ile?Lys?Met?Val?Gln Ala?Leu?Arg
4205 4210 4215
His?Gly Ile?Met?Pro?Ala?Thr Leu?His?Val?Asp?Thr Pro?Thr?Glu
4220 4225 4230
Gln?Val Asp?Trp?Ser?Thr?Gly Ala?Val?Glu?Leu?Leu Thr?Glu?Ala
4235 4240 4245
Arg?Glu Trp?Pro?Arg?Asp?Gly Arg?Pro?Arg?Arg?Ala Gly?Val?Ser
4250 4255 4260
Ser?Phe Gly?Ala?Ser?Gly?Thr Asn?Ala?His?Leu?Ile Leu?Glu?Glu
4265 4270 4275
Ala?Pro Glu?Glu?Val?Ala?Ala Pro?Pro?Val?Ser?Ser Ala?Gly?Val
4280 4285 4290
Val?Pro Leu?Val?Val?Ser?Ala Arg?Ser?Ala?Gly?Ser Leu?Ala?Gly
4295 4300 4305
Gln?Ala Gly?Arg?Leu?Ala?Ala Phe?Val?Glu?Glu?Ser Asp?Gly?Ala
4310 4315 4320
Ala?Leu Ala?Glu?Val?Ala?Gly Ala?Leu?Val?Ala?Gly Arg?Ala?Val
4325 4330 4335
Leu?Gly Glu?Arg?Ala?Val?Val Val?Ala?Gly?Ser?Arg Asp?Asp?Ala
4340 4345 4350
Val?Ala Gly?Leu?Arg?Val?Leu Ala?Arg?Gly?Glu?Gly Gly?Thr?Asn
4355 4360 4365
Leu?Val Ser?Gly?Ser?Ala?Gly Ser?Gly?Ala?Pro?Gly Lys?Val?Val
4370 4375 4380
Trp?Val Phe?Pro?Gly?Gln?Gly Ser?Gln?Trp?Ala?Gly Met?Gly?Arg
4385 4390 4395
Glu?Leu Leu?Asp?Ala?Ser?Pro Val?Phe?Ala?Gly?Arg Ile?Ala?Glu
4400 4405 4410
Cys?Val Ala?Ala?Leu?Glu?Pro Trp?Ile?Asp?Trp?Ser Leu?Val?Glu
4415 4420 4425
Val?Leu?Arg Gly?Glu?Ala?Glu Pro?Ala?Leu?Leu?Glu Arg?Val?Asp
4430 4435 4440
Val?Leu Gln?Pro?Ala?Ser?Phe Ala?Val?Met?Val?Gly Leu?Ala?Ala
4445 4450 4455
Val?Trp Ala?Ser?Val?Gly?Val Glu?Pro?Asp?Ala?Val Leu?Gly?His
4460 4465 4470
Ser?Gln Gly?Glu?Ile?Ala?Ala Ala?Cys?Val?Ser?Gly Ala?Leu?Ser
4475 4480 4485
Leu?Glu Asp?Ala?Ala?Arg?Val Val?Ala?Leu?Arg?Ser Gln?Ala?Ile
4490 4495 4500
Arg?Asp Gln?Leu?Ala?Gly?Arg Gly?Gly?Met?Ala?Ser Val?Ala?Leu
4505 4510 4515
Ser?Glu Ala?Asp?Ala?Val?Ala Arg?Leu?Glu?Arg?Trp Ala?Asp?Arg
4520 4525 4530
Val?Glu Val?Ala?Ala?Val?Asn Gly?Pro?Ser?Ser?Val Val?Val?Ala
4535 4540 4545
Gly?Asp Ala?Gly?Ala?Leu?Asp Glu?Ala?Leu?Glu?Ala Leu?Ser?Ala
4550 4555 4560
Asp?Gly Val?Arg?Val?Arg?Arg Val?Ala?Val?Asp?Tyr Ala?Ser?His
4565 4570 4575
Thr?Arg His?Val?Glu?Asp?Ile Arg?Glu?Ile?Leu?Ala Asp?Thr?Leu
4580 4585 4590
Ala?Gly Val?Asn?Ala?Gln?Ala Pro?Ser?Ile?Pro?Phe Tyr?Ser?Thr
4595 4600 4605
Val?Thr Gly?Glu?Trp?Val?Asp Gln?Ala?Gly?Val?Leu Asp?Gly?Ala
4610 4615 4620
Tyr?Trp Tyr?Arg?Asn?Leu?Arg Ser?Gln?Val?Gly?Phe Gly?Pro?Ala
4625 4630 4635
Val?Ala Glu?Leu?Ile?Gly?Gln Gly?His?Gly?Val?Phe Val?Glu?Val
4640 4645 4650
Ser?Ala His?Pro?Val?Leu?Val Gln?Pro?Ile?Thr?Glu Thr?Val?Tyr
4655 4660 4665
Ala?Ala Gly?Val?Asp?Thr?Glu Ala?Leu?Val?Thr?Gly Ser?Leu?Arg
4670 4675 4680
Arg?Asp Asp?Gly?Gly?Leu?Arg Arg?Leu?Leu?Ala?Ser Met?Ala?Glu
4685 4690 4695
Leu?Phe Val?Arg?Gly?Val?Thr Val?Asp?Trp?Ser?Gly Val?Leu?Pro
4700 4705 4710
Ala?Gly Ala?Thr?Ser?Ala?Arg Ile?Glu?Leu?Pro?Thr Tyr?Ala?Phe
4715 4720 4725
Asp?His Gln?Arg?Tyr?Trp?Leu Gln?Glu?Ala?Glu?Gly Ala?Asp?Glu
4730 4735 4740
Ala?Ala Gly?Val?Ala?Glu?Gly Ala?Asp?Ser?Asp?Phe Trp?Glu?Ala
4745 4750 4755
Val?Glu Arg?Ala?Asp?Leu?Asp Ala?Leu?Thr?Glu?Leu Leu?Glu?Thr
4760 4765 4770
Ala?Ser Ala?Glu?Asp?Arg?Gly Ala?Leu?Ser?Ser?Val Val?Pro?Val
4775 4780 4785
Leu?Ala Glu?Trp?Arg?Gly?Lys Arg?Arg?Glu?Arg?Ser Ser?Ala?Glu
4790 4795 4800
Lys?Leu Arg?Tyr?His?Val?Thr Trp?Gln?Pro?Leu?Glu Arg?Glu?Ala
4805 4810 4815
Ala?Gly Val?Pro?Gly?Gly?Gln Trp?Leu?Val?Val?Val Pro?Ser?Glu
4820 4825 4830
Arg?Pro Asp?Asp?Thr?Ala?Ile Asp?Ala?Leu?Leu?Asp Glu?Leu?Ala
4835 4840 4845
Gly?Gln Gly?Leu?Asp?Met?Val Leu?Leu?Glu?Val?Asp Asp?Ser?Asp
4850 4855 4860
Arg?Thr Arg?Ala?Arg?Leu?Val Glu?Arg?Leu?Thr?Ala Val?Leu?Pro
4865 4870 4875
Gly?Arg Asp?Val?Ser?Gly?Val Leu?Ser?Leu?Leu?Ala Leu?Asp?Glu
4880 4885 4890
Arg?Thr Ala?Gly?Gly?Pro?Gln Asp?Pro?Leu?Ala?Val Thr?Ala?Ser
4895 4900 4905
Thr?Leu Ala?Leu?Ile?Gln?Ala Leu?Ala?Asp?Ser?Arg Val?Thr?G1n
4910 4915 4920
Pro?Leu Trp?Cys?Leu?Thr?Arg Gly?Ala?Val?Asn?Ile Gly?Ile?His
4925 4930 4935
Asp?Thr Leu?Thr?Ser?Pro?Ala Gln?Ala?Ala?Leu?Trp Gly?Leu?Gly
4940 4945 4950
Arg?Ala Ala?Ala?Leu?Glu?Arg Leu?Asp?Arg?Trp?Gly Gly?Leu?Val
4955 4960 4965
Asp?Leu Pro?Ala?Arg?Thr?Asp Ala?Arg?Thr?Gly?Gln Tyr?Leu?Leu
4970 4975 4980
Gly?Val Leu?Asn?Gly?Ala?Gly Asp?Glu?Asp?Gln?Leu Ala?Val?Arg
4985 4990 4995
Arg?Ser Gly?Val?Tyr?Ser?Arg Arg?Leu?Leu?Arg?Lys Pro?Val?Pro
5000 5005 5010
Asp?Ala Thr?Ala?Gly?Asp?Gly Arg?Trp?Gln?Pro?Arg Gly?Thr?Val
5015 5020 5025
Leu?Val Thr?Gly?Gly?Ala?Glu Gly?Leu?Gly?Arg?His Val?Ala?Val
5030 5035 5040
Arg?Leu Ala?Leu?Ser?Gly?Ala Asp?Arg?Ile?Val?Val Thr?Thr?Thr
5045 5050 5055
Ala?Gln Ala?Pro?Glu?Gly?Ala Val?Pro?Asp?Leu?Ala Ala?Glu?Leu
5060 5065 5070
Ala?Gly Leu?Gly?Leu?Ala?Thr Ala?Val?Glu?Ser?Cys Ala?Asp?Thr
5075 5080 5085
Asp?Arg Asp?Thr?Ile?Ala?Arg Leu?Leu?Asp?Val?Pro Glu?Gln?Pro
5090 5095 5100
Leu?Thr Ala?Val?Val?His?Ala Ala?Asp?Ile?Thr?Arg Thr?Ser?Ser
5105 5110 5115
Leu?Asp Asp?Thr?Asp?Gly?Ala Ala?Leu?Ala?Glu?Val Phe?Ala?Ala
5120 5125 5130
Lys?Val Asp?Thr?Ala?Val?Trp Leu?Asp?Glu?Arg?Phe Gln?Asp?Thr
5135 5140 5145
Pro?Leu Asp?Ala?Phe?Val?Val Phe?Ser?Ser?Ile?Ala Gly?Val?Trp
5150 5155 5160
Gly?Gly Gly?Gly?Gln?Gly?Pro Ser?Gly?Ala?Ala?Asn Ala?Val?Leu
5165 5170 5175
Asp?Ala Leu?Val?Glu?Trp?Arg Arg?Ala?Arg?Gly?Leu Arg?Ala?Thr
5180 5185 5190
Ala?Ile Ala?Cys?Gly?Ala?Leu Asp?Glu?Ile?Gly?Val Gly?Met?Asp
5195 5200 5205
Glu?Ala Ala?Leu?Ala?Gln?Leu Arg?Arg?Arg?Gly?Val Leu?Pro?Val
5210 5215 5220
Ala?Pro Glu?Leu?Ala?Val?Thr Ala?Met?Val?Gln?Ala Val?Gln?Gly
5225 5230 5235
Asn?Glu Lys?Phe?Val?Thr?Val Ala?Asp?Met?Asp?Trp Gly?Ala?Phe
5240 5245 5250
Val?Pro Ala?Phe?Thr?Ser?Val Arg?Thr?Ser?Pro?Leu Phe?Ala?Asp
5255 5260 5265
Leu?Pro Glu?Ala?Lys?Ala?Val Leu?Gln?Ala?Ala?Arg Gln?Asp?Ser
5270 5275 5280
Glu?Asp Ser?Asp?Ala?Ala?Ala Ser?Leu?Ala?Asp?Ser Leu?Arg?Ala
5285 5290 5295
Val?Ser Asp?Thr?Glu?Gln?Asn Arg?Leu?Leu?Leu?Arg Leu?Val?Arg
5300 5305 5310
Gly?His Ala?Ser?Val?Val?Leu Gly?His?Gly?Gly?Ala Glu?Gly?Ile
5315 5320 5325
Gly?Pro Arg?Gln?Ala?Phe?Gln Glu?Val?Gly?Phe?Asp Ser?Leu?Ala
5330 5335 5340
Ala?Val Asn?Leu?Arg?Asn?Ser Leu?Gly?Thr?Ala?Thr Gly?Leu?Arg
5345 5350 5355
Leu?Pro Ala?Thr?Leu?Ile?Phe Asp?Tyr?Pro?Thr?Pro Glu?Ala?Leu
5360 5365 5370
Val?Gly Tyr?Leu?Arg?Ala?Glu Leu?Leu?Gln?Glu?Ala Asp?Asp?Gly
5375 5380 5385
Pro?Asp Ala?Arg?Glu?Asp?Asp Leu?Arg?Arg?Val?Leu Ala?Ser?Val
5390 5395 5400
Pro?Phe Ala?Arg?Phe?Lys?Glu Ala?Gly?Val?Leu?Asp Ala?Leu?Leu
5405 5410 5415
Gly?Leu Ala?Glu?Asp?Gly?Ser Gly?Val?Gly?Gly?Ser Gly?Ala?Gly
5420 5425 5430
Gly?Ala Ala?Gly?Gly?Asp?Ala Ash?Val?Asp?Gly?Pro Ala?Ala?Gly
5435 5440 5445
Glu?Ala Thr?Ala?Ala?Gly?Thr Glu?Glu?Leu?Ile?Asp Ala?Met?Asp
5450 5455 5460
Val?Ala Gly?Leu?Val?Gln?Arg Ala?Leu?Gly?Lys?Thr Ser
5465 5470 5475
<210>3
<211>3626
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>3
Met?Ser?Ala?Pro?Asp?Glu?Gln?Val?Val?Asp?Ala?Leu?Arg?Ala?Ser?Leu
1 5 10 15
Lys?Glu?Asn?Ala?Arg?Leu?Gln?Gln?Glu?Asn?Ser?Glu?Leu?Ala?Ala?Ala
20 25 30
Ala?Thr?Glu?Pro?Ile?Ala?Ile?Val?Ser?Met?Ala?Cys?Arg?Tyr?Ala?Gly
35 40 45
Gly?Ile?Arg?Ser?Pro?Glu?Asp?Leu?Trp?Arg?Val?Val?Ser?Glu?Gly?Ala
50 55 60
Asp?Val?Tyr?Thr?Pro?Phe?Pro?Asp?Asp?Arg?Gly?Trp?Asp?Leu?Glu?Gly
65 70 75 80
Leu?Tyr?His?Pro?Asp?Pro?Asp?Asn?Pro?Gly?Thr?Thr?Tyr?Val?Arg?Glu
85 90 95
Gly?Ala?Phe?Leu?His?Asp?Ala?Ala?Arg?Phe?Asp?Ala?Ala?Phe?Phe?Gly
100 105 110
Ile?Ser?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Gln?Leu
115 120 125
Leu?Glu?Val?Ser?Trp?Glu?Ala?Leu?Glu?Arg?Ala?Gly?Ile?Asp?Pro?His
130 135 140
Ser?Val?Arg?Gly?Ser?Asp?Ile?Gly?Val?Phe?Ala?Gly?Met?Val?His?Gln
145 150 155 160
Asp?Tyr?Ala?Pro?Asp?Leu?Ser?Gly?His?Glu?Asp?Phe?Leu?Ser?Leu?Glu
165 170 175
Arg?Ala?Leu?Gly?Thr?Ala?Gly?Gly?Val?Ala?Ser?Gly?Arg?Val?Ala?Tyr
180 185 190
Thr?Leu?Gly?Leu?Glu?Gly?Pro?Ala?Val?Thr?Val?Asp?Thr?Met?Cys?Ser
195 200 205
Ser?Ser?Leu?Val?Ala?Thr?His?Leu?Ala?Ala?Gln?Ala?Leu?Arg?Arg?Gly
210 215 220
Glu?Cys?Ser?Met?Ala?Leu?Val?Gly?Gly?Ser?Thr?Val?Met?Ala?Thr?Pro
225 230 235 240
Gly?Gly?Phe?Val?Gly?Phe?Ala?Arg?Gln?Arg?Ala?Leu?Ala?Phe?Asp?Gly
245 250 255
Arg?Cys?Lys?Ser?Tyr?Ala?Ala?Gly?Ala?Asp?Gly?Ser?Gly?Trp?Ala?Glu
260 265 270
Gly?Val?Gly?Val?Leu?Leu?Leu?Glu?Arg?Leu?Ser?Val?Ala?Glu?Glu?Arg
275 280 285
Gly?His?Arg?Ile?Leu?Ala?Val?Leu?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp
290 295 300
Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ala?Gln?Gln?Arg
305 310 315 320
Val?Ile?Arg?Lys?Ala?Leu?Ala?Ser?Ala?Gly?Leu?Ser?Ala?Ala?Asp?Val
325 330 335
Asp?Ala?Val?Glu?Gly?His?Gly?Thr?Gly?Thr?Val?Leu?Gly?Asp?Pro?Ile
340 345 350
Glu?Ala?Gln?Ala?Leu?Ile?Ala?Thr?Tyr?Gly?Gln?Gly?Arg?Asp?Pro?Arg
355 360 365
Lys?Pro?Leu?Trp?Leu?Gly?Ser?Val?Lys?Ser?Val?Ile?Gly?His?Thr?Gln
370 375 380
Ala?Ala?Ser?Gly?Val?Ala?Gly?Val?Ile?Lys?Thr?Val?Gln?Ala?Leu?Arg
385 390 395 400
His?Arg?Val?Leu?Pro?Ala?Thr?Leu?His?Leu?Asp?Ala?Pro?Thr?Pro?Gln
405 410 415
Val?Asp?Trp?Ser?Ala?Gly?Ala?Val?Glu?Leu?Leu?Thr?Glu?Ala?Arg?Glu
420 425 430
Trp?Pro?Asp?Gln?Gly?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly
435 440 445
Ala?Ser?Gly?Thr?Asn?Ala?His?Leu?Ile?Leu?Glu?Glu?Ala?Pro?Pro?Glu
450 455 460
Ala?Asn?Glu?Thr?Ala?Arg?Lys?Thr?Thr?Gly?Pro?Ala?Arg?Asn?Ala?Ala
465 470 475 480
Glu?Ser?Ala?Gln?Asp?Asp?Ala?Arg?Asp?Ala?Gly?Pro?Ala?Asp?Ala?Val
485 490 495
Pro?Leu?Val?Val?Ser?Ala?Gly?Thr?Ala?Thr?Ser?Leu?Ala?Ala?Gln?Ala
500 505 510
Glu?Arg?Leu?Ala?Ser?Phe?Val?Glu?Ser?Gly?Ala?Gly?Gly?Ala?Ser?Leu
515 520 525
Thr?Asp?Val?Ala?Gly?Ala?Leu?Val?Thr?Gly?Arg?Ala?Val?Leu?Gly?Glu
530 535 540
Arg?Ala?Val?Val?Val?Ala?Ser?Ser?Gly?Ala?Glu?Ala?Leu?Ala?Gly?Leu
545 550 555 560
Arg?Ala?Leu?Ser?Arg?Gly?Glu?Ser?Ala?Pro?Gly?Val?Leu?Ser?Gly?Ser
565 570 575
Gly?Thr?Pro?Gly?Lys?Val?Val?Trp?Val?Phe?Pro?Gly?Gln?Gly?Ser?Gln
580 585 590
Trp?Ala?Gly?Met?Gly?Arg?Glu?Leu?Leu?Asp?Thr?Ser?Pro?Val?Phe?Ala
595 600 605
Ala?Arg?Ile?Ala?Glu?Cys?Ala?Ala?Ala?Leu?Glu?Arg?Trp?Val?Asp?Trp
610 615 620
Ser?Leu?Val?Asp?Val?Leu?Arg?Gly?Glu?Ala?Glu?Pro?Gly?Val?Leu?Glu
625 630 635 640
Arg?Val?Asp?Val?Leu?Gln?Pro?Ala?Ser?Phe?Ala?Val?Met?Val?Gly?Leu
645 650 655
Ala?Ala?Val?Trp?Gln?Ser?Val?Gly?Val?Glu?Pro?Asp?Ala?Val?Val?Gly
660 665 670
His?Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala?Cys?Val?Ser?Gly?Ala?Leu?Thr
675 680 685
Leu?Glu?Asp?Ala?Ala?Arg?Val?Val?Ala?Leu?Arg?Ser?Gln?Ala?Ile?Ala
690 695 700
Glu?Arg?Leu?Ala?Gly?Arg?Gly?Gly?Met?Ala?Ser?Val?Ala?Leu?Asn?Glu
705 710 715 720
Ala?Glu?Ala?Glu?Ser?Arg?Leu?Glu?Arg?Trp?Ala?Asp?Arg?Val?Glu?Val
725 730 735
Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val?Ile?Ala?Gly?Asp?Ala?Glu
740 745 750
Ala?Leu?Asp?Glu?Ala?Leu?Asp?Thr?Leu?Glu?Asp?Gln?Gly?Val?Arg?Val
755 760 765
Arg?Arg?Ile?Ala?Val?Asp?Tyr?Ala?Ser?His?Thr?Arg?His?Val?Glu?Arg
770 775 780
Ile?Arg?Asp?Thr?Leu?Ala?Asp?Ala?Leu?Ala?Gly?Ile?Gly?Ala?Gln?Ala
785 790 795 800
Pro?Ala?Val?Pro?Phe?Tyr?Ser?Thr?Val?Thr?Gly?Glu?Trp?Val?Glu?Asp
805 810 815
Ala?Gly?Val?Leu?Asp?Gly?Ala?Tyr?Trp?Tyr?Arg?Asn?Leu?Arg?Gly?Gln
820 825 830
Val?Gly?Phe?Gly?Pro?Ala?Val?Ala?Glu?Leu?Val?Arg?Gln?Gly?His?Gly
835 840 845
Val?Phe?Val?Glu?Val?Ser?Ala?His?Pro?Val?Leu?Val?Gln?Pro?Ile?Asn
850 855 860
Glu?Thr?Val?Tyr?Asp?Thr?Gly?Thr?Ala?Thr?Gly?Thr?Gly?Asp?Val?Thr
865 870 875 880
Asp?Val?Val?Val?Thr?Gly?Ser?Leu?Arg?Arg?Gln?Asp?Gly?Gly?Pro?Arg
885 890 895
Arg?Leu?Arg?Thr?Ser?Met?Ala?Glu?Leu?Phe?Val?His?Gly?Val?Pro?Val
900 905 910
Asp?Trp?Ser?Lys?Val?Leu?Pro?Asp?Gly?Ala?Ala?Ala?Ala?Arg?Val?Asp
915 920 925
Leu?Pro?Thr?Tyr?Ala?Phe?Asp?His?Gln?His?Phe?Trp?Leu?Lys?Met?Gly
930 935 940
Gly?Thr?Ala?Thr?Asp?Gln?Ala?Ser?Leu?Gly?Leu?Thr?Gly?Ala?Asp?His
945 950 955 960
Pro?Leu?Leu?Gly?Ala?Val?Val?Glu?Leu?Pro?Gln?Ser?Asp?Gly?Leu?Val
965 970 975
Phe?Thr?Ser?Arg?Leu?Ser?Leu?Gln?Ser?His?Pro?Trp?Leu?Ala?Gly?His
980 985 990
Ala?Ile?Gly?Gly?Val?Val?Ile?Val Pro?Gly?Thr?Val?Tyr Val?Asp?Leu
995 1000 1005
Ala?Val Arg?Ala?Gly?Asp?Glu Phe?Gly?His?Gly?Ile Leu?Glu?Glu
1010 1015 1020
Leu?Val Ile?Glu?Ala?Pro?Leu Val?Leu?Pro?Glu?Arg Gly?Gly?Val
1025 1030 1035
Arg?Val Gln?Val?Ala?Val?Ser Gly?Pro?Gly?Ala?Asn Gly?Leu?Arg
1040 1045 1050
Thr?Val Asp?Val?Tyr?Ser?Leu Arg?Glu?Asp?Ala?Ala Gly?Glu?Gly
1055 1060 1065
Gly?Thr His?Gly?Trp?Thr?Arg His?Ala?Thr?Gly?Leu Leu?Ser?Ala
1070 1075 1080
Ala?Pro Ala?Ala?Arg?Asp?Asp Ser?Asp?Phe?Asp?Phe Ala?Ala?Trp
1085 1090 1095
Pro?Pro Pro?Gly?Ala?Gln?Pro Val?Asp?Val?Glu?Asn Phe?Tyr?Asp
1100 1105 1110
Asp?Leu Thr?Glu?Arg?Gly?Tyr Ala?Tyr?Gly?Pro?Ala Phe?Gln?Gly
1115 1120 1125
Leu?Arg Ala?Val?Trp?Arg?Arg Gly?Asp?Glu?Val?Phe Ala?Glu?Ala
1130 1135 1140
Ala?Leu Pro?Gln?Glu?Gln?Arg Glu?Asp?Ala?Gly?Arg Phe?Gly?Ile
1145 1150 1155
His?Pro Ala?Leu?Leu?Asp?Ala Ala?Leu?His?Thr?Asn Ala?Leu?Ala
1160 1165 1170
Ala?Pro Asp?Asp?Gly?Arg?Lys Val?Leu?Pro?Phe?Ala Trp?Asn?Gly
1175 1180 1185
Leu?Val Leu?His?Ala?Thr?Gly Ala?Ser?Ala?Leu?Arg Val?Arg?Val
1190 1195 1200
Ala?Pro Cys?Gly?Pro?Asp?Ala Leu?Ser?Phe?Gln?Ala Ala?Asp?Glu
1205 1210 1215
Thr?Gly Gly?Leu?Val?Leu?Thr Met?Asp?Ser?Leu?Val Ser?Leu?Pro
1220 1225 1230
Val?Ser Thr?Asp?Gln?Leu?Asp Ala?Ala?Ala?Ala?His Asp?Thr?Arg
1235 1240 1245
Asp?Ala Leu?Phe?Gly?Val?Glu Trp?Thr?Gly?Leu?Pro Ser?Val?Gln
1250 1255 1260
Glu?Ala Val?Pro?Val?Pro?Val Trp?Val?Pro?Val?Val Ser?Ala?Gly
1265 1270 1275
Asp?Val Val?Glu?Leu?Ala?Arg Gly?Ala?Gly?Ala?Gly Val?Pro?Ala
1280 1285 1290
Val?Ala Val?Leu?Glu?Ala?Val Ala?Ala?Gly?Asp?Gly Ala?Gly?Asp
1295 1300 1305
Ala?Ala Leu?Gly?Leu?Thr?Ser Arg?Val?Leu?Gly?Val Val?Gln?Ala
1310 1315 1320
Trp?Leu Gly?Ala?Ala?Gly?Leu Glu?Asn?Ser?Arg?Leu Val?Val?Val
1325 1330 1335
Thr?Arg Gly?Ala?Val?Pro?Ala Gly?Asp?Gly?Val?Val Ser?Asp?Pro
1340 1345 1350
Ala?Gly Ser?Ala?Val?Trp?Gly Leu?Val?Arg?Ala?Ala Gln?Ala?Glu
1355 1360 1365
Asn?Pro Asp?Arg?Ile?Val?Leu Val?Asp?Ala?Asp?Pro Ala?Ala?Ala
1370 1375 1380
Ala?Asp Asp?Gly?Arg?Asp?Ala Val?Leu?Ala?Ala?Leu Thr?Ala?Gly
1385 1390 1395
Asp?Glu Pro?Gln?Leu?Ala?Val Arg?Gly?Thr?Thr?Leu Ser?Val?Pro
1400 1405 1410
Arg?Leu Ala?Arg?Val?Thr?Gly Gln?Val?Pro?Asp?Ser Pro?Asp?Ile
1415 1420 1425
Phe?Arg Pro?Gln?Gly?Thr?Val Leu?Val?Thr?Gly?Gly Thr?Gly?Ser
1430 1435 1440
Leu?Gly Ala?Leu?Val?Ala?Arg His?Leu?Val?Thr?Arg Tyr?Gly?Val
1445 1450 1455
Arg?His Leu?Val?Leu?Val?Gly Arg?Arg?Gly?Pro?Asp Ala?Glu?Gly
1460 1465 1470
Met?Pro Glu?Leu?Val?Ala?Glu Leu?Ala?Glu?Gln?Gly Ala?Ala?Val
1475 1480 1485
Ser?Val Val?Ala?Gly?Asp?Val Ser?Arg?Arg?Ala?Asp Val?Glu?Ala
1490 1495 1500
Leu?Leu Ala?Ser?Val?Pro?Asp Glu?His?Pro?Leu?Cys Gly?Val?Val
1505 1510 1515
His?Leu Ala?Gly?Val?Leu?Asp Asp?Gly?Val?Ile?Ala Ala?Leu?Thr
1520 1525 1530
Pro?Glu Arg?Leu?Ala?Thr?Val Phe?Ala?Pro?Lys?Val Asp?Ala?Val
1535 1540 1545
Arg?His Leu?Asp?Ala?Leu?Thr Arg?Asp?Leu?Asp?Leu Asp?Ala?Phe
1550 1555 1560
Val?Val Phe?Ser?Ser?Ala?Ala Ala?Leu?Met?Gly?Ser Ala?Gly?Gln
1565 1570 1575
Gly?Asn Tyr?Ala?Ala?Ala?Asn Ala?Phe?Leu?Asp?Gly Leu?Met?Ala
1580 1585 1590
Thr?Arg Arg?Glu?Ala?Gly?Leu Pro?Gly?Leu?Ser?Leu Ala?Trp?Gly
1595 1600 1605
Leu?Trp Glu?Gln?Ser?Thr?Gly Leu?Thr?Ala?His?Leu Gly?Ala?Val
1610 1615 1620
Asp?Gln Ala?Arg?Met?Ser?Arg Gly?Gly?Val?Leu?Ala Leu?Thr?Pro
1625 1630 1635
Ala?Glu Gly?Leu?His?Ile?Leu Asp?Leu?Gly?Leu?His Met?Gly?Gln
1640 1645 1650
Ala?Leu Leu?Val?Pro?Ile?Lys Leu?Asp?Leu?Arg?Thr Leu?Arg?Ala
1655 1660 1665
Gln?Ala Gly?Asp?Gly?Gly?Gly Val?Pro?His?Leu?Leu Arg?Gly?Leu
1670 1675 1680
Val?Arg Ala?Gly?Arg?Arg?Ser Ala?Arg?Ala?Ala?Ala Gly?Asp?Ser
1685 1690 1695
Gly?Thr Leu?Val?Arg?Arg?Leu Ala?Gly?Leu?Ser?Gln Ala?Glu?Gln
1700 1705 1710
Glu?Ser Val?Leu?Leu?Ser?Val Val?Gln?Thr?Glu?Ala Gly?Ala?Val
1715 1720 1725
Leu?Gly Phe?Thr?Ser?Gln?Glu Leu?Thr?Gln?Gly?Thr Arg?Gly?Phe
1730 1735 1740
Ser?Asp Ile?Gly?Phe?Asp?Ser Leu?Thr?Ala?Val?Glu Leu?Arg?Asn
1745 1750 1755
Arg?Leu Ser?Ala?Ala?Thr?Gly Val?Lys?Leu?Pro?Ala Thr?Leu?Ile
1760 1765 1770
Phe?Asp Tyr?Pro?Thr?Pro?Val Ala?Leu?Ala?Arg?His Leu?Arg?Glu
1775 1780 1785
Glu?Leu Gly?Asp?Ala?Asp?Thr Thr?Val?Thr?Gly?Val Pro?Ala?Ala
1790 1795 1800
Ala?Thr Ala?Ala?Thr?Thr?Ala Asp?Pro?Gly?Glu?Pro Ile?Ala?Ile
1805 1810 1815
Val?Gly Met?Ala?Cys?Arg?Leu Pro?Gly?Gly?Val?Thr Ser?Pro?Asp
1820 1825 1830
Asp?Leu Trp?His?Leu?Val?Arg Glu?Gly?Arg?Glu?Gly Val?Ser?Ala
1835 1840 1845
Phe?Pro Asp?Asp?Arg?Gly?Trp Asp?Leu?Glu?Gly?Leu Phe?Asp?Thr
1850 1855 1860
Asp?Pro Asp?Arg?Ala?Gly?Thr Ser?Tyr?Ala?Thr?Gln Gly?Gly?Phe
1865 1870 1875
Leu?Glu Gly?Ala?Gly?Leu?Phe Asp?Ala?Gly?Phe?Phe Gly?Ile?Ser
1880 1885 1890
Pro?Arg Glu?Ala?Leu?Ala?Met Asp?Pro?Gln?Gln?Arg Leu?Leu?Leu
1895 1900 1905
Glu?Ala Ser?Trp?Glu?Ala?Leu Glu?Arg?Ala?Gly?Ile Asp?Pro?Ser
1910 1915 1920
Thr?Ala Arg?Gly?Asp?Asn?Ile Gly?Val?Phe?Ser?Gly Val?Ser?Ile
1925 1930 1935
His?Asp Tyr?Leu?Glu?Ser?Leu Ser?Asp?Met?Pro?Ala Glu?Leu?Glu
1940 1945 1950
Gly?Phe Val?Thr?Thr?Ala?Thr Ala?Gly?Ser?Val?Ala Ser?Gly?Arg
1955 1960 1965
Val?Ser Tyr?Val?Phe?Gly?Phe Glu?Gly?Pro?Ala?Val Thr?Val?Asp
1970 1975 1980
Thr?Ala Cys?Ser?Ser?Ser?Leu Val?Ala?Met?His?Leu Ala?Ala?Gln
1985 1990 1995
Ala?Leu Arg?Gln?Gly?Glu?Cys Thr?Met?Ala?Leu?Ala Gly?Gly?Val
2000 2005 2010
Ala?Val Met?Gly?Ser?Pro?Ile Gly?Val?Leu?Gly?Met Ser?Arg?Gln
2015 2020 2025
Arg?Gly Leu?Ala?Ala?Asp?Gly Arg?Cys?Lys?Ala?Tyr Ala?Asp?Asp
2030 2035 2040
Ala?Asp Gly?Thr?Val?Leu?Ser Glu?Gly?Val?Gly?Leu Val?Val?Leu
2045 2050 2055
Glu?Arg Leu?Ser?Val?Ala?Arg Glu?Arg?Gly?His?Lys Val?Leu?Ala
2060 2065 2070
Val?Ile Arg?Gly?Ser?Ala?Val Asn?Gln?Asp?Gly?Ala Ser?Asn?Gly
2075 2080 2085
Leu?Thr Ala?Pro?Asn?Gly?Pro Ser?Gln?Gln?Arg?Val Ile?Arg?Arg
2090 2095 2100
Ala?Leu Thr?Ser?Ala?Gly?Leu Ser?Ala?Ala?Asp?Val Asp?Ala?Val
2105 2110 2115
Glu?Gly His?Gly?Thr?Gly?Thr Val?Leu?Gly?Asp?Pro Ile?Glu?Ala
2120 2125 2130
Gln?Ala Leu?Leu?Ala?Thr?Tyr Gly?Lys?Gly?Arg?Asp Ala?Gly?Arg
2135 2140 2145
Pro?Leu Trp?Leu?Gly?Ser?Leu Lys?Ser?Asn?Val?Gly His?Thr?Gln
2150 2155 2160
Ala?Ala Ala?Gly?Val?Ala?Gly Val?Ile?Lys?Met?Val Gln?Ala?Leu
2165 2170 2175
Arg?His Gly?Ile?Met?Pro?Pro Thr?Leu?His?Ala?Gln Gln?Arg?Thr
2180 2185 2190
Thr?Arg Val?Asp?Trp?Thr?Asp Gly?Ala?Ile?Glu?Leu Leu?Thr?Glu
2195 2200 2205
Ala?Arg Glu?Trp?Pro?Arg?Glu Asp?Arg?Pro?Arg?Arg Ala?Gly?Val
2210 2215 2220
Ser?Ser Phe?Gly?Ile?Ser?Gly Thr?Asn?Ala?His?Leu Ile?Leu?Glu
2225 2230 2235
Glu?Ala Pro?Glu?Glu?Val?Ala Val?Pro?Pro?Val?Ser Ser?Ala?Gly
2240 2245 2250
Val?Val Pro?Leu?Val?Val?Ser Ala?Arg?Ser?Ala?Gly Ser?Leu?Ala
2255 2260 2265
Gly?Gln Ala?Gly?Arg?Leu?Ala Ala?Phe?Val?Glu?Glu Thr?Asp?Gly
2270 2275 2280
Ala?Ala Leu?Thr?Glu?Val?Ala Gly?Ala?Leu?Val?Ala Gly?Arg?Ala
2285 2290 2295
Val?Leu Ser?Glu?Arg?Ala?Val Val?Val?Ala?Glu?Ser Gly?Ala?Glu
2300 2305 2310
Ala?Leu Ala?Gly?Leu?Arg?Ser Leu?Ala?Glu?Gly?Glu Ser?Ala?Pro
2315 2320 2325
Gly?Val Val?Ser?Gly?Ser?Ala Ser?Ser?Gly?Ala?Pro Gly?Lys?Val
2330 2335 2340
Val?Trp Val?Phe?Pro?Gly?Gln Gly?Ser?Gln?Trp?Ala Gly?Met?Gly
2345 2350 2355
Arg?Glu Leu?Leu?Asp?Ala?Ser Pro?Val?Phe?Ala?Glu Arg?Ile?Ala
2360 2365 2370
Glu?Cys Ala?Ala?Ala?Leu?Glu Pro?Trp?Ile?Asp?Trp Ser?Leu?Val
2375 2380 2385
Asp?Val Leu?Arg?Gly?Glu?Val Glu?Pro?Ala?Val?Leu Glu?Arg?Val
2390 2395 2400
Asp?Val Leu?Gln?Pro?Ala?Ser Phe?Ala?Val?Met?Val Gly?Leu?Ala
2405 2410 2415
Ala?Val Trp?Ser?Ser?Val?Gly Val?Leu?Pro?Asp?Ala Val?Val?Gly
2420 2425 2430
His?Ser Gln?Gly?Glu?Ile?Ala Ala?Ala?Cys?Val?Ser Gly?Ala?Leu
2435 2440 2445
Ser?Leu Glu?Asp?Ala?Ala?Arg Val?Val?Ala?Leu?Arg Ser?Gln?Ala
2450 2455 2460
Ile?Ala Gly?Gln?Leu?Ala?Gly Arg?Gly?Gly?Met?Ala Ser?Val?Ala
2465 2470 2475
Leu?Ser Glu?Ala?Asp?Ala?Ser Ala?Arg?Leu?Glu?Arg Trp?Ala?Gly
2480 2485 2490
Arg?Val Glu?Val?Ala?Ala?Val Asn?Gly?Pro?Ser?Ser Val?Val?Val
2495 2500 2505
Ala?Gly Asp?Ala?Glu?Ala?Leu Asp?Glu?Ala?Leu?Glu Ala?Leu?Ser
2510 2515 2520
Ala?Glu Gly?Val?Arg?Val?Arg Arg?Val?Ala?Val?Asp Tyr?Ala?Ser
2525 2530 2535
His?Thr Arg?His?Val?Glu?Asp Ile?Arg?Glu?Ile?Leu Ala?Glu?Thr
2540 2545 2550
Leu?Ala Gly?Val?Asn?Ala?Gln Ala?Pro?Met?Val?Pro Phe?Tyr?Ser
2555 2560 2565
Thr?Val Thr?Gly?Glu?Trp?Val Asp?Gln?Ala?Gly?Val Leu?Asp?Gly
2570 2575 2580
Ala?Tyr Trp?Tyr?Arg?Asn?Leu Arg?Gly?Gln?Val?Gly Phe?Gly?Pro
2585 2590 2595
Ala?Val Ala?Glu?Leu?Ile?Gly Gln?Gly?His?Gly?Val Phe?Val?Glu
2600 2605 2610
Val?Ser Ala?His?Pro?Val?Leu Val?Gln?Pro?Ile?Thr Glu?Ile?Leu
2615 2620 2625
Asp?Asp Gly?Gly?Asp?Gly?Thr Asp?Ala?Val?Val?Thr Gly?Ser?Leu
2630 2635 2640
Arg?Arg Asp?Asp?Gly?Gly?Leu Arg?Arg?Leu?Leu?Ala Ser?Met?Ala
2645 2650 2655
Glu?Leu Phe?Val?Arg?Gly?Leu Pro?Val?Asp?Trp?Thr Gly?Val?Leu
2660 2665 2670
Pro?Glu Thr?Arg?Thr?Gly?Trp Ala?Arg?Leu?Asp?Leu Pro?Thr?Tyr
2675 2680 2685
Ala?Phe Asp?His?Arg?His?Tyr Trp?Leu?Gln?Thr?Ala Arg?Ser?Val
2690 2695 2700
Thr?Asp Ala?Ala?Ser?Leu?Gly Gln?Ala?Ala?Ala?Asp His?Pro?Leu
2705 2710 2715
Leu?Gly Ala?Val?Val?Arg?Leu Pro?Gln?Thr?Asp?Gly Leu?Val?Phe
2720 2725 2730
Thr?Ser Arg?Leu?Ser?Leu?Lys Ser?His?Pro?Trp?Leu Ala?Asp?His
2735 2740 2745
Val?Val Gly?Gly?Met?Val?Leu Leu?Pro?Gly?Thr?Gly Leu?Val?Glu
2750 2755 2760
Leu?Ala Val?Arg?Ala?Gly?Asp Glu?Ala?Gly?Cys?Gly Val?Leu?Glu
2765 2770 2775
Glu?Leu Val?Thr?Glu?Ala?Pro Leu?Val?Val?Pro?Glu His?Gly?Gly
2780 2785 2790
Val?Arg Val?Gln?Val?Ala?Val Gly?Ala?Pro?Gly?Glu Asn?Gly?Ala
2795 2800 2805
Arg?Thr Val?Glu?Ile?Phe?Ser Gln?Arg?Glu?Asp?Ala Ala?Asp?Asp
2810 2815 2820
Gly?Asp Thr?Trp?Thr?Arg?His Ala?Thr?Gly?Leu?Leu Ser?Ala?Ser
2825 2830 2835
Val?Pro Ala?Gly?Gly?Gly?Glu His?Asp?Phe?Thr?Ala Trp?Pro?Pro
2840 2845 2850
Pro?Gly Ala?Gln?Pro?Val?Glu Ala?Gly?Asp?Leu?Tyr Ala?Gly?Leu
2855 2860 2865
Ala?Gly Gln?Gly?Tyr?Glu?Tyr Gly?Pro?Ala?Phe?Gln Gly?Val?Arg
2870 2875 2880
Ala?Val Trp?Arg?Arg?Gly?Glu Glu?Leu?Phe?Ala?Glu Val?Ala?Leu
2885 2890 2895
Pro?Glu Glu?His?Gly?Arg?Asp Ala?Glu?Arg?Phe?Gly Ile?His?Pro
2900 2905 2910
Ala?Leu Leu?Asp?Ala?Ala?Leu His?Val?Ser?Ala?Thr Asp?Ala?Ala
2915 2920 2925
Thr?Val Asn?Gly?Asp?Gly?Pro Arg?Arg?Pro?Phe?Asp Trp?Lys?Gly
2930 2935 2940
Leu?Val Leu?His?Ala?Ala?Gly Ala?Ser?Ala?Leu?Arg Val?Arg?Leu
2945 2950 2955
Val?Pro Gly?Gly?Thr?Asp?Thr Leu?Thr?Leu?Glu?Ala Ala?Asp?Glu
2960 2965 2970
Thr?Gly Ala?Pro?Val?Val?Ser Ala?Asp?Ser?Val?Val Met?Arg?Ala
2975 2980 2985
Leu?Ser Ala?Glu?Gln?Leu?Ala Arg?Pro?Asp?Gly?Met Ala?Ser?Ala
2990 2995 3000
Asn?Ser Leu?Phe?Leu?Leu?Asp Trp?Thr?Glu?Val?Ser Ser?Val?Gln
3005 3010 3015
Glu?Ala Val?Pro?Val?Pro?Val Trp?Val?Pro?Val?Val Ser?Ala?Gly
3020 3025 3030
Asp?Val Val?Glu?Leu?Ala?Arg Gly?Ala?Gly?Ala?Gly Val?Pro?Ala
3035 3040 3045
Val?Ala Val?Leu?Glu?Ala?Val Ala?Ala?Gly?Asp?Gly Ala?Gly?Asp
3050 3055 3060
Ala?Ala Leu?Gly?Leu?Thr?Ser Arg?Val?Leu?Gly?Val Val?Gln?Ala
3065 3070 3075
Trp?Leu Gly?Ala?Ala?Gly?Leu Glu?Asn?Ser?Arg?Leu Val?Val?Val
3080 3085 3090
Thr?Arg Gly?Ala?Val?Pro?Ala Gly?Asp?Gly?Val?Val Ser?Asp?Pro
3095 3100 3105
Ala?Gly Ser?Ala?Val?Trp?Gly Leu?Val?Arg?Ala?Ala Gln?Ala?Glu
3110 3115 3120
Asn?Pro Asp?Arg?Ile?Val?Leu Val?Asp?Ala?Asp?Pro Ala?Ala?Ala
3125 3130 3135
Ala?Gly Asp?Gly?Arg?Asp?Ala Val?Leu?Ala?Ala?Val Thr?Ala?Gly
3140 3145 3150
Asp?Glu Pro?Gln?Leu?Ala?Val Arg?Gly?Ala?Ala?His Phe?Val?Pro
3155 3160 3165
Arg?Leu Ala?Arg?Ala?Thr?Asp Asp?Gly?Arg?Val?Pro Asp?Gly?Thr
3170 3175 3180
Pro?Val Phe?Asp?Ala?Glu?Gly Thr?Val?Leu?Ile?Thr Gly?Gly?Thr
3185 3190 3195
Gly?Ser Leu?Gly?Ala?Leu?Ala Ala?Arg?His?Leu?Val Ser?Arg?Tyr
3200 3205 3210
Gly?Val Arg?His?Leu?Val?Leu Ala?Gly?Arg?Arg?Gly Pro?Asp?Ala
3215 3220 3225
Glu?Gly Ala?Gln?Glu?Leu?Ala Ala?Glu?Leu?Thr?Glu Leu?Gly?Ala
3230 3235 3240
Ala?Val Glu?Val?Val?Ala?Cys Asp?Val?Ser?Asp?Arg Ala?Gln?Val
3245 3250 3255
Glu?Ala Leu?Leu?Ala?Thr?Val Pro?Asp?Ala?His?Pro Leu?Arg?Gly
3260 3265 3270
Val?Ile His?Thr?Ala?Gly?Val Leu?Asp?Ala?Gly?Val Ile?Gly?Thr
3275 3280 3285
Leu?Thr Pro?Glu?Arg?Leu?Ala Arg?Val?Phe?Ala?Pro Lys?Val?Asp
3290 3295 3300
Ala?Val Arg?His?Leu?Asp?Glu Leu?Thr?Arg?Gly?Leu Asp?Leu?Asp
3305 3310 3315
Ala?Phe Val?Val?Tyr?Ser?Ser Val?Ser?Ser?Val?Phe Met?Gly?Ala
3320 3325 3330
Gly?Ser Gly?Ser?Tyr?Ala?Ala Ala?Asn?Ala?Tyr?Leu Asp?Gly?Leu
3335 3340 3345
Met?Ala Ala?Arg?Arg?Ala?Glu Gly?Leu?Pro?Gly?Leu Ser?Leu?Ala
3350 3355 3360
Trp?Gly Leu?Trp?Glu?Gln?Thr Ser?Gly?Met?Ala?Ala Asn?Thr?Asp
3365 3370 3375
Asp?Leu Thr?Arg?Ser?Arg?Met Ser?Arg?Arg?Gly?Gly Leu?Gln?Met
3380 3385 3390
Met?Thr Leu?Thr?Glu?Gly?Met Asp?Leu?Phe?His?Ala Ala?Leu?Gly
3395 3400 3405
Ser?Pro Arg?Ser?Leu?Leu?Val Pro?Ala?Lys?Leu?Asp Leu?Arg?Gly
3410 3415 3420
Val?Arg Ala?Asp?Ala?Ala?Ala Gly?Gly?Gly?Val?Pro His?Met?Leu
3425 3430 3435
Arg?Gly Leu?Val?Arg?Thr?Gly Arg?Arg?Ser?Ala?Gln Thr?Gly?Thr
3440 3445 3450
Ala?Gln Asp?Gly?Glu?Leu?Leu Arg?Arg?Leu?Ala?Gly Leu?Pro?Thr
3455 3460 3465
Ala?Asp Gln?Glu?Lys?Thr?Leu Val?Asp?Leu?Val?Arg Gly?Gln?Ala
3470 3475 3480
Ala?Ser Val?Leu?Gly?His?Ala Gly?Pro?Asp?Gly?Val Arg?Ala?Asp
3485 3490 3495
Thr?Ala Phe?Lys?Asp?Thr?Gly Phe?Asp?Ser?Leu?Thr Ser?Val?Glu
3500 3505 3510
Leu?Arg Asn?Arg?Leu?Arg?Ala Ala?Thr?Gly?Leu?Lys Leu?Pro?Ala
3515 3520 3525
Thr?Leu Val?Phe?Asp?Tyr?Pro Asn?Pro?Gln?Ala?Leu Ala?Arg?His
3530 3535 3540
Leu?His Thr?Glu?Leu?Phe?Pro Asp?Gly?Gly?Thr?Ala Gly?Gln?Asp
3545 3550 3555
Val?Asp Glu?Glu?Arg?Leu?Arg Arg?Ala?Leu?Ala?Ser Leu?Pro?Leu
3560 3565 3570
Ala?Arg Ile?Arg?Ala?Ala?Gly Leu?Met?Asp?Ala?Leu Val?Lys?Leu
3575 3580 3585
Ala?Ala Leu?Asp?Asp?Ser?Thr Pro?Val?Thr?Gly?Ala Phe?Asp?Asp
3590 3595 3600
Ala?Asp Glu?Glu?Met?Ala?Val Ala?Glu?Leu?Asp?Val Asp?Asp?Leu
3605 3610 3615
Val?Gln Leu?Ala?Leu?Gly?Asp Asn
3620 3625
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＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
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Val?Ser?Ala?Ser?Tyr?Glu?Lys?Val?Val?Glu?Ala?Leu?Arg?Lys?Ser?Val
1 5 10 15
Glu?Glu?Val?Gly?Ser?Leu?Lys?Lys?Arg?Asn?Arg?Arg?Leu?Val?Asp?Ala
20 25 30
Ser?Arg?Glu?Pro?Val?Ala?Val?Val?Gly?Met?Ala?Cys?Lys?Leu?Pro?Gly
35 40 45
Gly?Val?Ala?Gly?Pro?Glu?Asp?Leu?Trp?Arg?Leu?Val?Arg?Asp?Gly?Arg
50 55 60
Asp?Ala?Val?Thr?Gly?Phe?Pro?Glu?Asp?Arg?Gly?Trp?Asp?Leu?Glu?Gly
65 70 75 80
Leu?Phe?Asp?Pro?Asp?Pro?Asp?Arg?Ala?Gly?Thr?Ser?Tyr?Thr?Asp?Arg
85 90 95
Gly?Gly?Phe?Leu?His?Glu?Ala?Gly?Leu?Phe?Asp?Ala?Gly?Phe?Phe?Gly
100 105 110
Ile?Ser?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu
115 120 125
Leu?Glu?Thr?Ser?Trp?Glu?Ala?Phe?Glu?Ser?Ala?Gly?Ile?Asp?Pro?Leu
130 135 140
Ser?Leu?Lys?Gly?Ala?Asp?Val?Gly?Val?Phe?Ser?Gly?Val?Phe?Gly?Gln
145 150 155 160
Gly?Tyr?Val?Ala?Pro?Gly?Ala?Ser?Val?Val?Thr?Pro?Glu?Leu?Glu?Gly
165 170 175
Phe?Ala?Gly?Thr?Gly?Gly?Ser?Thr?Ser?Val?Ala?Ser?Gly?Arg?Val?Ser
180 185 190
Tyr?Val?Phe?Gly?Phe?Glu?Gly?Pro?Ala?Val?Thr?Ile?Asp?Ser?Ala?Cys
195 200 205
Ser?Ser?Ser?Leu?Val?Ala?Met?His?Leu?Ala?Ala?Gln?Ala?Leu?Arg?Gln
210 215 220
Gly?Glu?Cys?Ser?Met?Ala?Leu?Ala?Gly?Gly?Ala?Thr?Val?Met?Ala?Asn
225 230 235 240
Pro?Gly?Ala?Phe?Val?Glu?Phe?Ser?Arg?Gln?Arg?Gly?Leu?Ala?Asp?Asp
245 250 255
Gly?Arg?Cys?Lys?Ala?Tyr?Ala?Asp?Gly?Ala?Asp?Gly?Thr?Gly?Trp?Ala
260 265 270
Glu?Gly?Val?Gly?Val?Val?Val?Leu?Glu?Arg?Leu?Ser?Val?Ala?Arg?Glu
275 280 285
Arg?Gly?His?Arg?Val?Leu?Ala?Val?Leu?Arg?Gly?Ser?Ala?Val?Asn?Gln
290 295 300
Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ala?Gln?Gln
305 310 315 320
Arg?Val?Ile?Arg?Gly?Ala?Leu?Ala?Asn?Ala?Gly?Leu?Thr?Pro?Asp?Asp
325 330 335
Val?Asp?Val?Val?Glu?Gly?His?Gly?Thr?Gly?Thr?Val?Leu?Gly?Asp?Pro
340 345 350
Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Lys?Gly?Arg?Asp?Ala
355 360 365
Glu?Arg?Pro?Leu?Trp?Leu?Gly?Ser?Leu?Lys?Ser?Asn?Val?Gly?His?Thr
370 375 380
Gln?Ala?Ala?Ala?Gly?Val?Ala?Gly?Val?Ile?Lys?Met?Val?Gln?Ala?Leu
385 390 395 400
Arg?His?Gly?Val?Met?Pro?Ala?Thr?Leu?His?Val?Asp?Ala?Pro?Thr?Ser
405 410 415
Arg?Val?Asp?Trp?Ser?Ala?Gly?Ala?Val?Glu?Leu?Leu?Thr?Glu?Ala?Arg
420 425 430
Glu?Trp?Pro?Arg?Glu?Asp?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ala?Phe
435 440 445
Gly?Val?Ser?Gly?Thr?Asn?Ala?His?Leu?Ile?Leu?Glu?Glu?Ala?Pro?Glu
450 455 460
Glu?Val?Ala?Ala?Pro?Pro?Val?Ser?Ser?Ala?Gly?Val?Val?Pro?Leu?Val
465 470 475 480
Val?Ser?Ala?Arg?Ser?Ala?Gly?Ser?Leu?Ala?Gly?Gln?Ala?Gly?Arg?Leu
485 490 495
Ala?Ala?Phe?Val?Glu?Glu?Ser?Asp?Gly?Val?Ser?Pro?Ala?Ser?Val?Ala
500 505 510
Gly?Ala?Leu?Val?Ala?Gly?Arg?Ala?Val?Leu?Ser?Glu?Arg?Ala?Val?Val
515 520 525
Val?Ala?Glu?Ser?Gly?Ala?Glu?Ala?Leu?Gly?Gly?Leu?Ser?Ala?Leu?Ala
530 535 540
Arg?Gly?Glu?Ser?Ser?Thr?Asn?Leu?Val?Ser?Gly?Ser?Ala?Gly?Ser?Gly
545 550 555 560
Ala?Pro?Gly?Lys?Val?Val?Trp?Val?Phe?Pro?Gly?Gln?Gly?Ser?Gln?Trp
565 570 575
Ala?Gly?Met?Gly?Arg?Glu?Leu?Leu?Asp?Ala?Ser?Pro?Val?Phe?Ala?Glu
580 585 590
Arg?Ile?Ala?Glu?CysAla?Ala?Ala?Leu?Glu?Pro?Trp?Ile?Asp?Trp?Ser
595 600 605
Leu?Ile?Glu?Val?Leu?Arg?Gly?Glu?Ala?Glu?Pro?Ala?Leu?Leu?Glu?Arg
610 615 620
Val?Asp?Val?Leu?Gln?Pro?Ala?Ser?Phe?Ala?Val?Met?Val?Gly?Leu?Ala
625 630 635 640
Ala?Val?Trp?Ala?Ser?Val?Gly?Val?Glu?Pro?Asp?Ala?Val?Leu?Gly?His
645 650 655
Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala?Cys?Val?Ser?Gly?Ala?Leu?Ser?Leu
660 665 670
Glu?Asp?Ala?Ala?Arg?Val?Val?Ala?Leu?Arg?Ser?Gln?Ala?Ile?Ala?Gly
675 680 685
Gln?Leu?Ala?Gly?Arg?Gly?Gly?Met?Ala?Ser?Val?Ala?Leu?Ser?Glu?Ala
690 695 700
Asp?Ala?Val?Ala?Arg?Leu?Thr?Arg?Trp?Ala?Asp?Arg?Val?Glu?Val?Ala
705 710 715 720
Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val?Val?Ala?Gly?Asp?Ala?Glu?Ala
725 730 735
Leu?Asp?Glu?Ala?Leu?Glu?Ala?Leu?Ser?Ala?Glu?Gly?Val?Arg?Val?Arg
740 745 750
Arg?Val?Ala?Val?Asp?Tyr?Ala?Ser?His?Thr?Arg?His?Val?Glu?Asp?Ile
755 760 765
Arg?Glu?Ile?Leu?Ala?Asp?Thr?Leu?Ala?Glu?Val?Glu?Ala?Gln?Ala?Pro
770 775 780
Ser?Ile?Pro?Phe?Tyr?Ser?Thr?Val?Thr?Gly?Glu?Trp?Val?Asp?Gln?Ala
785 790 795 800
Gly?Val?Leu?Asp?Gly?Ala?Tyr?Trp?Tyr?Arg?Asn?Leu?Arg?Gly?Gln?Val
805 810 815
Gly?Phe?Gly?Pro?Ala?Val?Ala?Glu?Leu?Thr?Ala?Gln?Gly?His?Gly?Val
820 825 830
Phe?Val?Glu?Val?Ser?Ala?His?Pro?Val?Leu?Val?Gln?Pro?Ile?Thr?Glu
835 840 845
Ile?Leu?Asp?Asp?Gly?Gly?Asp?Gly?Thr?Asp?Ala?Val?Val?Thr?Gly?Ser
850 855 860
Leu?Arg?Arg?Asp?Asp?Gly?Gly?Leu?Arg?Arg?Leu?Leu?Ala?Ser?Met?Ala
865 870 875 880
Glu?Leu?Phe?Val?Arg?Gly?Val?Pro?Val?Asp?Trp?Thr?Gly?Val?Leu?Pro
885 890 895
Ala?Gly?Ala?Thr?Ser?Ala?Arg?Leu?Asp?Leu?Pro?Thr?Tyr?Ala?Phe?Asp
900 905 910
His?Gln?His?Tyr?Trp?Leu?Gln?Glu?Val?Glu?Ser?Ala?Thr?Asp?Ala?Ala
915 920 925
Ser?Leu?Gly?Gln?Ala?Ala?Ala?Asp?His?Pro?Leu?Leu?Gly?Ala?Val?Val
930 935 940
Arg?Leu?Pro?Gln?Thr?Asp?Gly?Leu?Val?Phe?Thr?Ser?Arg?Leu?Ser?Leu
945 950 955 960
Lys?Ser?His?Pro?Trp?Leu?Ala?Asp?His?Ala?Val?Gly?Gly?Val?Val?Ile
965 970 975
Leu?Pro?Gly?Thr?Gly?Leu?Val?Glu?Leu?Ala?Val?Arg?Ala?Gly?Asp?Glu
980 985 990
Ala?Gly?Cys?Gly?Val?Leu?Glu?Glu Leu?Val?Ile?Glu?Ala Pro?Leu?Val
995 1000 1005
Val?Pro Glu?His?Gly?Gly?Val Arg?Val?Gln?Val?Ala Val?Gly?Ala
1010 1015 1020
Pro?Gly Glu?Asn?Gly?Ser?Arg Thr?Val?Glu?Ile?Phe Ser?Gln?Arg
1025 1030 1035
Glu?Asp Gly?Pro?Gly?Asp?Gly Asp?Thr?Trp?Ala?Arg His?Ala?Thr
1040 1045 1050
Gly?Thr Leu?Ser?Val?Ala?Ala Ser?Ala?Thr?Gly?Glu Arg?Thr?Asp
1055 1060 1065
Phe?Thr Ala?Trp?Pro?Pro?Ala Gly?Ala?Ala?Pro?Val Glu?Ile?Gly
1070 1075 1080
Asp?Phe Tyr?Gly?Gly?Leu?Ser Glu?Arg?Gly?Tyr?Gly Tyr?Gly?Pro
1085 1090 1095
Ala?Phe Gln?Gly?Val?Arg?Ala Val?Trp?Arg?Arg?Gly Glu?Glu?Val
1100 1105 1110
Phe?Ala Glu?Val?Ala?Leu?Pro Glu?Glu?His?Arg?Lys Asp?Ala?Glu
1115 1120 1125
Arg?Phe Gly?Ile?His?Pro?Ala Leu?Leu?Asp?Ala?Ala Leu?Gln?Ala
1130 1135 1140
Gly?Thr Ile?Gly?Ser?Ala?Ala Asp?Ala?Glu?Asp?Ser Gly?Glu?Pro
1145 1150 1155
Val?Leu Ala?Phe?Ala?Trp?Asn Gly?Leu?Val?Leu?His Ala?Ala?Gly
1160 1165 1170
Ala?Ser Ala?Leu?Arg?Val?Arg Ile?Ala?Pro?Asn?Gly Pro?Asp?Ala
1175 1180 1185
Leu?Ser Val?Gln?Ala?Ala?Asp Glu?Ala?Gly?Gly?Pro Val?Val?Thr
1190 1195 1200
Leu?Asp Ser?Leu?Val?Ser?Arg Ala?Val?Ser?Ala?Glu Gln?Leu?Asp
1205 1210 1215
Thr?Ala Thr?Asp?Thr?Thr?Val Ala?Asn?Ala?Leu?Phe Arg?Leu?Glu
1220 1225 1230
Trp?Ser Glu?Leu?Pro?Pro?Pro Gln?Gly?Ala?Glu?Phe Pro?Pro?Ser
1235 1240 1245
Trp?Val Pro?Val?Phe?Ala?Pro Gly?Asp?Val?Glu?Ala Leu?Ala?Glu
1250 1255 1260
Ser?Ala Gly?Val?Pro?Ala?Val Ala?Val?Leu?Glu?Ala Val?Gly?Gly
1265 1270 1275
Asp?Gly Asp?Asp?Ala?Val?Leu Thr?Leu?Thr?Ser?Gly Val?Leu?Ala
1280 1285 1290
Val?Val Gln?Ala?Trp?Leu?Ala Ala?Asp?Gly?Leu?Glu Glu?Ser?Arg
1295 1300 1305
Leu?Val Val?Ala?Thr?Arg?Gly Ala?Val?Pro?Ala?Gly Asp?Gly?Gly
1310 1315 1320
Val?Val Thr?Asp?Pro?Ala?Gly Ala?Ala?Val?Trp?Gly Leu?Val?Arg
1325 1330 1335
Ala?Ala Gln?Ser?Glu?Ala?Pro Asp?Arg?Ile?Val?Leu Leu?Asp?Thr
1340 1345 1350
Asp?Pro Ala?Ala?Glu?Asp?Gly Val?Asp?Ser?Val?Leu Asp?Ser?Val
1355 1360 1365
Leu?Gly Pro?Val?Thr?Ala?Thr Ala?Glu?Pro?Gln?Val Ala?Val?Arg
1370 1375 1380
Gly?Thr Thr?Leu?Ser?Val?Pro Arg?Leu?Ala?Arg?Val Thr?Asp?Arg
1385 1390 1395
Val?Ala Asp?Thr?Ala?Gly?Val Phe?Gly?Ser?Asp?Gly Thr?Val?Leu
1400 1405 1410
Val?Ser Gly?Ala?Gly?Ser?Leu Gly?Gly?Leu?Val?Ala Arg?His?Leu
1415 1420 1425
Val?Ser Arg?His?Gly?Val?Arg His?Leu?Val?Leu?Ala Ser?Arg?Arg
1430 1435 1440
Gly?Pro Asp?Ala?Glu?Gly?Val Pro?Glu?Leu?Val?Ala Glu?Leu?Ala
1445 1450 1455
Gly?Gln Gly?Ala?Ala?Val?Glu Val?Val?Ala?Cys?Asp Val?Ser?Asp
1460 1465 1470
Arg?Thr Gln?Val?Glu?Ala?Leu Leu?Ala?Thr?Val?Ser Asp?Ala?His
1475 1480 1485
Pro?Leu Arg?Gly?Val?Val?His Thr?Ala?Gly?Val?Phe Asp?Asp?Gly
1490 1495 1500
Leu?Ile Gly?Ala?Leu?Thr?Pro Glu?Arg?Leu?Ala?Arg Val?Phe?Ala
1505 1510 1515
Pro?Lys Val?Asp?Ala?Val?Arg His?Leu?Asp?Ala?Leu Thr?Arg?Asp
1520 1525 1530
Leu?Asp Leu?Asp?Ala?Phe?Val Val?Tyr?Ser?Ser?Val Ala?Gly?Leu
1535 1540 1545
Ser?Gly Gly?Ala?Gly?Gln?Gly Asn?Tyr?Ser?Ala?Ala Asn?Ala?Phe
1550 1555 1560
Leu?Asp Gly?Leu?Met?Ser?His Arg?Arg?Ala?Ala?Gly Leu?Pro?Gly
1565 1570 1575
Leu?Ser Leu?Ala?Trp?Gly?Leu Trp?Glu?Gln?Ser?Leu Gly?Met?Ala
1580 1585 1590
Gly?His Leu?Ser?Ala?Val?Asp Gln?Ala?Arg?Ala?Ser Arg?Ser?Gly
1595 1600 1605
Val?Leu Glu?Ile?Ser?Ala?Thr Glu?Gly?Met?Glu?Leu Phe?Asp?Ala
1610 1615 1620
Ala?Leu Val?Ser?Glu?Arg?Ala Leu?Leu?Val?Pro?Val Lys?Leu?Asp
1625 1630 1635
Leu?Arg Thr?Val?Arg?Ala?Asp Ala?Ser?Ala?Gly?Ala Ala?Val?Pro
1640 1645 1650
His?Leu Leu?Arg?Gly?Leu?Val Arg?Thr?Gly?Arg?Gln Gln?Ala?Arg
1655 1660 1665
Ala?Val Ala?Gly?Ser?Ala?Gly Ala?Gly?Gly?Leu?Leu Ser?Asp?Arg
1670 1675 1680
Leu?Ala Gly?Leu?Val?Pro?Ala Glu?Gln?Glu?Thr?Leu Leu?Leu?Asp
1685 1690 1695
Leu?Val Arg?Ala?Gln?Ala?Ala Val?Val?Leu?Gly?His Ser?Glu?Pro
1700 1705 1710
Gly?Gly Val?Arg?Ala?Asp?Met Ala?Phe?Lys?Asp?Ala Gly?Phe?Asp
1715 1720 1725
Ser?Leu Thr?Ser?Val?Glu?Leu Arg?Asn?Arg?Leu?Arg Glu?Ala?Thr
1730 1735 1740
Gly?Leu Lys?Leu?Pro?Pro?Thr Leu?Val?Phe?Asp?Tyr Pro?Ser?Pro
1745 1750 1755
Gln?Ala Leu?Ala?Arg?Tyr?Leu Arg?Glu?Glu?Phe?Gly Glu?Val?Ala
1760 1765 1770
Ala?Pro Glu?Ala?Thr?Ala?Pro Ala?Val?Val?Ala?Ala Asp?Ala?Asn
1775 1780 1785
Glu?Pro Val?Ala?Ile?Val?Gly Met?Ala?Cys?Arg?Leu Pro?Gly?Gly
1790 1795 1800
Val?Ala Ser?Pro?Glu?Gln?Leu Trp?Lys?Leu?Val?Ala Glu?Gly?Val
1805 1810 1815
Asp?Ala Val?Ser?Asp?Phe?Pro Gly?Asp?Arg?Gly?Trp Asp?Leu?Glu
1820 1825 1830
Gly?Leu Phe?Asp?Pro?Asp?Pro Asp?Gln?Ala?Gly?Lys Ser?Tyr?Thr
1835 1840 1845
Ser?Gln Gly?Gly?Phe?Leu?Glu Gly?Ala?Gly?Leu?Phe Asp?Ala?Gly
1850 1855 1860
Phe?Phe Gly?Ile?Ser?Pro?Arg Glu?Ala?Leu?Ala?Met Asp?Pro?Gln
1865 1870 1875
Gln?Arg Leu?Leu?Leu?Glu?Thr Ser?Trp?Glu?Ala?Leu Glu?Gly?Ala
1880 1885 1890
Gly?Leu Asp?Pro?Thr?Ser?Leu Lys?Gly?Thr?Asp?Val Gly?Val?Phe
1895 1900 1905
Ser?Gly Val?Ser?Gly?Gln?Gly Tyr?Gly?Thr?Gly?Val Leu?Ala?Pro
1910 1915 1920
Glu?Val Glu?Gly?Phe?Ala?Gly Thr?Gly?Leu?Ala?Ser Ser?Val?Ala
1925 1930 1935
Ser?Gly Arg?Val?Ser?Tyr?Val Phe?Gly?Phe?Glu?Gly Pro?Ala?Val
1940 1945 1950
Ser?Val Asp?Thr?Ala?Cys?Ser Ser?Ser?Leu?Val?Ala Met?His?Leu
1955 1960 1965
Ala?Ala Gln?Ala?Leu?Arg?Gln Gly?Glu?Cys?Ser?Met Ala?Leu?Ala
1970 1975 1980
Gly?Gly Ala?Met?Val?Met?Ala Thr?Pro?Ala?Thr?Phe Met?Ala?Phe
1985 1990 1995
Ser?Arg Gln?Arg?Gly?Leu?Ala Gly?Asp?Gly?Arg?Cys Lys?Ala?Phe
2000 2005 2010
Ala?Glu Gly?Ala?Asp?Gly?Met Gly?Leu?Ser?Glu?Gly Val?Gly?Val
2015 2020 2025
Val?Val Leu?Glu?Arg?Leu?Ser Val?Ala?Arg?Glu?Arg Gly?His?Lys
2030 2035 2040
Ile?Leu Ala?Val?Leu?Arg?Gly Ser?Ala?Val?Asn?Gln Asp?Gly?Ala
2045 2050 2055
Ser?Asn Gly?Leu?Thr?Ala?Pro Asn?Gly?Pro?Ser?Gln Gln?Arg?Val
2060 2065 2070
Ile?Arg Arg?Ala?Leu?Ala?Ser Ala?Gly?Ile?Glu?Ala Asp?Gly?Val
2075 2080 2085
Asp?Val Val?Glu?Gly?His?Gly Thr?Gly?Thr?Ala?Leu Gly?Asp?Pro
2090 2095 2100
Ile?Glu Ala?Gln?Ala?Leu?Leu Ala?Thr?Tyr?Gly?Lys Asp?Arg?Asp
2105 2110 2115
Pro?Arg Gln?Pro?Leu?Trp?Leu Gly?Ser?Leu?Lys?Ser Asn?Ile?Gly
2120 2125 2130
His?Ala Gln?Ala?Ala?Ala?Gly Val?Ala?Ser?Val?Ile Lys?Met?Val
2135 2140 2145
Gln?Ala Leu?Arg?His?Gly?Leu Met?Pro?Pro?Thr?Leu His?Ala?Gln
2150 2155 2160
Arg?Pro Ser?Asp?Gln?Val?Asp Trp?Ser?Ala?Gly?Ala Val?Glu?Leu
2165 2170 2175
Leu?Thr Glu?Ala?Arg?Glu?Trp Pro?Arg?Asp?Gly?Arg Pro?Arg?Arg
2180 2185 2190
Ala?Gly Val?Ser?Ser?Phe?Gly Val?Ser?Gly?Thr?Asn Val?His?Leu
2195 2200 2205
Ile?Leu Glu?Glu?Ala?Pro?Glu Glu?Asp?Ala?Pro?Gln Gly?Val?Pro
2210 2215 2220
Ala?Gly Gly?Gly?Gly?Val?Val Pro?Leu?Val?Val?Ser Ala?Arg?Ser
2225 2230 2235
Ala?Gly Ala?Leu?Ala?Gly?Gln Ala?Gly?Arg?Leu?Ala Ala?Phe?Val
2240 2245 2250
Glu?Glu Thr?Asp?Gly?Ala?Ala Leu?Thr?Glu?Val?Ala Gly?Ala?Leu
2255 2260 2265
Val?Ala Gly?Arg?Ala?Val?Leu Gly?Glu?Arg?Ala?Val Val?Val?Ala
2270 2275 2280
Gly?Ser Arg?Asp?Asp?Ala?Val Ala?Gly?Leu?Arg?Val Leu?Ala?Glu
2285 2290 2295
Gly?Ala Thr?Ala?Pro?Gly?Val Val?Ser?Gly?Ser?Ala Gly?Ser?Gly
2300 2305 2310
Ala?Pro Gly?Lys?Val?Val?Trp Val?Phe?Pro?Gly?Gln Gly?Ser?Gln
2315 2320 2325
Trp?Ala Gly?Met?Gly?Arg?Glu Leu?Leu?Asp?Ala?Ser Pro?Val?Phe
2330 2335 2340
Ala?Glu Arg?Val?Ala?Glu?Cys Ala?Ala?Ala?Leu?Glu Pro?Trp?Ile
2345 2350 2355
Asp?Trp Ser?Leu?Val?Asp?Val Leu?Arg?Gly?Glu?Ala Glu?Pro?Ala
2360 2365 2370
Val?Leu Glu?Arg?Val?Asp?Val Leu?Gln?Pro?Ala?Ser Phe?Ala?Val
2375 2380 2385
Met?Val Gly?Leu?Ala?Ala?Val Trp?Ser?Ser?Val?Gly Val?Leu?Pro
2390 2395 2400
Asp?Ala Val?Val?Gly?His?Ser Gln?Gly?Glu?Ile?Ala Ala?Ala?Cys
2405 2410 2415
Val?Ser Gly?Ala?Leu?Ser?Leu Glu?Asp?Ala?Ala?Arg Val?Val?Ala
2420 2425 2430
Leu?Arg Ser?Gln?Ala?Ile?Ala Gly?Gln?Leu?Ala?Gly Arg?Gly?Gly
2435 2440 2445
Met?Ala Ser?Val?Ala?Leu?Ser Glu?Ala?Asp?Ala?Ser Ala?Cys?Leu
2450 2455 2460
Glu?Arg Trp?Ala?Asp?Arg?Val Glu?Val?Ala?Ala?Val Asn?Gly?Pro
2465 2470 2475
Ser?Ser Val?Val?Val?Ala?Gly Asp?Ala?Glu?Ala?Leu Asp?Glu?Ala
2480 2485 2490
Leu?Glu Ala?Met?Ser?Ala?Glu Gly?Val?Arg?Val?Arg Arg?Val?Ala
2495 2500 2505
Val?Asp Tyr?Ala?Ser?His?Thr Arg?His?Val?Glu?Asp Ile?Arg?Glu
2510 2515 2520
Ile?Leu Ala?Asp?Thr?Leu?Ala Gly?Val?Asn?Ala?Gln Ala?Pro?Met
2525 2530 2535
Val?Pro Phe?Tyr?Ser?Thr?Val Thr?Gly?Glu?Trp?Val Lys?Asp?Ala
2540 2545 2550
Gly?Val Leu?Asp?Gly?Ala?Tyr Trp?Tyr?Arg?Asn?Leu Arg?Gly?Gln
2555 2560 2565
Val?Gly Phe?Gly?Pro?Ala?Val Thr?Asp?Leu?Leu?Ser Gln?Gly?His
2570 2575 2580
Arg?Thr Phe?Val?Glu?Val?Ser Ala?His?Pro?Val?Leu Val?Gln?Pro
2585 2590 2595
Ile?Thr Glu?Ile?Leu?Asp?Asp Gly?Gly?Asp?Gly?Thr Asp?Ala?Val
2600 2605 2610
Val?Thr Gly?Ser?Leu?Arg?Arg Asp?Asp?Gly?Gly?Leu Arg?Arg?Leu
2615 2620 2625
Leu?Ala Ser?Met?Ala?Glu?Leu Phe?Val?Arg?Gly?Val Pro?Val?Asp
2630 2635 2640
Trp?Thr Gly?Val?Leu?Pro?Glu Thr?Gly?Ala?Thr?Ser Ala?Arg?Leu
2645 2650 2655
Asp?Leu Pro?Thr?Tyr?Ala?Phe Asp?His?Gln?His?Tyr Trp?Leu?Gln
2660 2665 2670
Thr?Ala Arg?Ser?Val?Thr?Asp Ala?Val?Ser?Leu?Gly Gln?Ala?Ala
2675 2680 2685
Ala?Asp His?Pro?Leu?Leu?Gly Ala?Val?Val?Arg?Leu Pro?Gln?Thr
2690 2695 2700
Asp?Gly Leu?Val?Phe?Thr?Ser Arg?Leu?Ser?Leu?Lys Ser?His?Pro
2705 2710 2715
Trp?Leu Ala?Asp?His?Val?Val Gly?Gly?Met?Val?Leu Leu?Pro?Gly
2720 2725 2730
Thr?Gly Leu?Val?Glu?Leu?Ala Val?Arg?Ala?Gly?Asp Glu?Ala?Gly
2735 2740 2745
Cys?Gly Val?Leu?Glu?Glu?Leu Val?Thr?Glu?Ala?Pro Leu?Val?Val
2750 2755 2760
Pro?Glu His?Gly?Gly?Val?Arg Val?Gln?Val?Ala?Val Gly?Ala?Pro
2765 2770 2775
Gly?Glu Asn?Gly?Ser?Arg?Thr Val?Glu?Ile?Phe?Ser Gln?Arg?Glu
2780 2785 2790
Asp?Ala Ala?Asp?Asp?Gly?Asp Thr?Trp?Thr?Arg?His Ala?Thr?Gly
2795 2800 2805
Met?Leu Ala?Asp?Ala?Pro?Gln Pro?Gly?Ala?Ser?Thr Ala?Glu?Phe
2810 2815 2820
Asp?Phe Ala?Ala?Trp?Pro?Pro Ala?Asp?Ala?Arg?Gln Val?Glu?Leu
2825 2830 2835
Asp?Thr Gly?Glu?Leu?Tyr?Glu Gly?Leu?Leu?Glu?Arg Gly?Tyr?Ala
2840 2845 2850
Tyr?Gly Pro?Val?Phe?Gln?Gly Val?Arg?Ala?Val?Trp Arg?Arg?Gly
2855 2860 2865
Glu?Glu Leu?Phe?Ala?Glu?Val Ala?Leu?Pro?Asp?Glu Asn?Arg?Lys
2870 2875 2880
Glu?Ser Gly?Asp?Phe?Gly?Ile His?Pro?Ala?Leu?Leu Asp?Ala?Ala
2885 2890 2895
Leu?Gln Ala?Gly?Thr?Phe?Ala Val?Ala?Ala?Asp?Thr Ser?Gln?Glu
2900 2905 2910
Glu?Ala Gly?Gln?Pro?Val?Met Pro?Phe?Ala?Trp?Asn Gly?Leu?Val
2915 2920 2925
Leu?His Ala?Ala?Gly?Ala?Ser Ala?Leu?Arg?Val?Arg Val?Ala?Pro
2930 2935 2940
Asn?Gly Pro?Asp?Ala?Leu?Ser Val?Thr?Ala?Ala?Asp Ala?Ser?Gly
2945 2950 2955
Thr?Pro Val?Leu?Thr?Met?Asp Ser?Leu?Val?Met?Arg Ala?Val?Ser
2960 2965 2970
Ile?Glu Gln?Leu?Gly?Ala?Thr Ala?Ala?Asp?Glu?Ser Arg?Asp?ser
2975 2980 2985
Leu?Phe Ala?Val?Arg?Trp?Thr Glu?Leu?Pro?Pro?Ala Gln?Glu?Thr
2990 2995 3000
Glu?Pro Ala?Pro?Pro?Trp?Leu Pro?Val?Thr?Thr?Ala Asp?Asp?Leu
3005 3010 3015
Ala?Ala Leu?Ala?Ala?Gly?Gly Gly?Val?Pro?Ala?Val Ala?Val?Met
3020 3025 3030
Glu?Ala Val?Gly?Gly?Ala?Gly Asp?Asp?Ala?Val?Leu Ala?Leu?Ser
3035 3040 3045
Ser?Arg Val?Leu?Ala?Met?Val Gln?Ala?Trp?Leu?Gly Val?Pro?Gly
3050 3055 3060
Ala?Glu Glu?Ser?Arg?Leu?Val Val?Ala?Thr?Arg?Gly Ala?Val?Pro
3065 3070 3075
Ala?Gly Asp?Asp?Gly?Ala?Val Thr?Asp?Pro?Ala?Gly Ala?Ala?Val
3080 3085 3090
Trp?Gly Leu?Val?Arg?Ala?Ala Gln?Ser?Glu?Asn?Pro Asp?Arg?Val
3095 3100 3105
Val?Leu Leu?Asp?Thr?Asp?Pro Gly?Ala?Glu?Gly?Gly Val?Glu?Pro
3110 3115 3120
Val?Leu Asp?Ser?Val?Leu?Ala Ala?Val?Leu?Ala?Ser Gly?Glu?Pro
3125 3130 3135
Gln?Val Ala?Val?Arg?Gly?Gly Val?Leu?Ser?Val?Pro Arg?Leu?Val
3140 3145 3150
Arg?Ala Thr?Ala?Gln?Gly?Met Asp?Thr?Asn?Pro?Val Phe?Arg?Glu
3155 3160 3165
Gln?Gly Thr?Val?Leu?Val?Ser Gly?Gly?Gly?Ser?Leu Gly?Ala?Leu
3170 3175 3180
Ala?Ala Arg?His?Leu?Val?Ser Arg?His?Gly?Val?Arg His?Leu?Val
3185 3190 3195
Leu?Ala Ser?Arg?Arg?Gly?Pro Asp?Ala?Glu?Gly?Val Arg?Glu?Leu
3200 3205 3210
Ala?Ala Glu?Leu?Ser?Gly?Gln Gly?Ala?Thr?Val?Ser Val?Val?Ala
3215 3220 3225
Cys?Asp Val?Ser?Asp?Arg?Thr Gln?Val?Ala?Ser?Leu Leu?Ala?Gln
3230 3235 3240
Met?Pro Ala?Glu?His?Pro?Leu Arg?Gly?Val?Val?His Thr?Ala?Gly
3245 3250 3255
Val?Phe Asp?Pro?Gly?Val?Ile Gly?Ala?Leu?Thr?Pro Glu?Arg?Leu
3260 3265 3270
Ala?Arg Val?Phe?Ala?Pro?Lys Val?Asp?Ala?Val?Arg His?Leu?Asp
3275 3280 3285
Glu?Leu Thr?Arg?Asp?Leu?Ala Leu?Asp?Ala?Phe?Val Val?Tyr?Ser
3290 3295 3300
Ser?Ala Ser?Ser?Val?Phe?Met Gly?Ala?Gly?Ser?Gly Gly?Tyr?Ala
3305 3310 3315
Ala?Ala Asn?Ala?Tyr?Leu?Asp Gly?Leu?Met?Ser?His Arg?Arg?Ala
3320 3325 3330
Ala?Gly Leu?Pro?Gly?Leu?Ser Leu?Ser?Trp?Gly?Pro Trp?Glu?Gln
3335 3340 3345
Val?Thr Gly?Met?Ala?Gly?Asn Ile?Asp?Asp?Leu?Thr Arg?Thr?Arg
3350 3355 3360
Met?Ser Arg?Arg?Glu?Gly?Arg Gly?Gly?Val?Gln?Ala Leu?Arg?Ser
3365 3370 3375
Ala?Glu Gly?Met?Glu?Leu?Phe Asp?Ala?Ala?Leu?Arg Ser?Glu?Glu
3380 3385 3390
Ser?Leu Leu?Val?Pro?Ala?Arg Leu?Asp?Leu?Arg?Ala Val?Arg?Ala
3395 3400 3405
Asp?Ala Ala?Ala?Gly?Gly?Gly Val?Pro?His?Leu?Leu Arg?Gly?Leu
3410 3415 3420
Val?Arg Ala?Gly?Arg?Gln?Pro Val?Arg?Thr?Thr?Gly Gly?Gly?Gly
3425 3430 3435
Asp?Arg Arg?Gln?Leu?Ala?Asp Arg?Leu?Val?Gly?Leu Ser?Ala?Ala
3440 3445 3450
Lys?Gln Glu?Ala?Leu?Leu?Leu Gly?Val?Val?Cys?Ala Gln?Ala?Ala
3455 3460 3465
Val?Val Leu?Gly?His?Ser?Gly Pro?Glu?Ser?Val?Arg Val?Glu?Met
3470 3475 3480
Ala?Phe Asn?Glu?Ala?Gly?Phe Asp?Ser?Leu?Thr?Ser Val?Glu?Leu
3485 3490 3495
Arg?Asn Arg?Leu?Arg?Glu?Ala Thr?Gly?Leu?Lys?Leu Pro?Ala?Thr
3500 3505 3510
Leu?Val Phe?Asp?His?Pro?Thr Pro?Leu?Ala?Leu?Ala Arg?Tyr?Leu
3515 3520 3525
Arg?Ala Glu?Leu?Ala?Val?Asp Glu?Ala?Cys?Pro?Ala Asp?Ala?Val
3530 3535 3540
Leu?Ala Gly?Leu?Ala?Gly?Leu Glu?Ala?Val?Ile?Glu Ser?Ala?Gly
3545 3550 3555
Ala?Asp Glu?Glu?Ala?Arg?Asp Arg?Ile?Thr?Val?Arg Leu?Leu?Glu
3560 3565 3570
Leu?Leu Arg?Ala?Ala?Glu?Ala Thr?Gly?Gly?Pro?Gly Glu?Asp?Pro
3575 3580 3585
Val?Gly Ala?Asp?Ala?Ala?Asp Glu?Asp?Leu?Asp?Thr Ala?Thr?Asp
3590 3595 3600
Glu?Glu Leu?Phe?Ala?Leu?Val Asp?Gln?Leu?Asp
3605 3610
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Val?Arg?Asp?Pro?Thr?His?Arg?His?Arg?Thr?His?Ser?Phe?Ser?Trp?Gly
1 5 10 15
Leu?Asn?Pro?Val?Ala?Asp?Glu?Ala?Glu?Leu?Arg?Asp?Tyr?Leu?Lys?Arg
20 25 30
Ala?Ile?Ala?Asp?Ala?Arg?Thr?Ala?Arg?Lys?Arg?Leu?Arg?Glu?Val?Gln
35 40 45
Glu?Glu?Ala?Arg?Glu?Pro?Ile?Ala?Ile?Val?Ser?Met?Ala?Cys?Arg?Tyr
50 55 60
Pro?Gly?Gly?Val?Ser?Thr?Pro?Glu?Glu?Leu?Trp?Thr?Leu?Val?Ala?Asp
65 70 75 80
Gly?Val?Asp?Ala?Val?Ser?Asp?Phe?Pro?Gln?Asp?Arg?Gly?Trp?Asp?Leu
85 90 95
Glu?Gly?Leu?Phe?Asp?Ser?Asp?Pro?Asp?His?Ala?Gly?Thr?Ser?Tyr?Val
100 105 110
Thr?Gln?Gly?Gly?Phe?Leu?Glu?Gly?Ala?Gly?Leu?Phe?Asp?Ala?Gly?Phe
115 120 125
Phe?Gly?Ile?Ser?Pro?Arg?Glu?Ala?Leu?Ala?Met?Asp?Pro?His?Gln?Arg
130 135 140
Leu?Leu?Leu?Glu?Thr?Ser?Trp?Glu?Ala?Val?Glu?Arg?Ala?Gly?Ile?Asp
145 150 155 160
Pro?Leu?Ser?Leu?Lys?Gly?Thr?Asp?Val?Gly?Val?Phe?Ser?Gly?Leu?Ser
165 170 175
Gly?Gln?Gly?Tyr?Gly?Ala?Gly?Ala?Gly?Val?Val?Thr?Pro?Glu?Thr?Glu
180 185 190
Gly?Phe?Ala?Gly?Thr?Gly?Ala?Ser?Thr?Ser?Val?Ala?Ser?Gly?Arg?Val
195 200 205
Ser?Tyr?Val?Leu?Gly?Phe?Glu?Gly?Pro?Ala?Val?Ser?Leu?Asp?Thr?Ala
210 215 220
Cys?Ser?Ser?Ser?Leu?Val?Ala?Ile?His?Leu?Ala?Ala?Gln?Ala?Leu?Arg
225 230 235 240
Gln?Gly?Glu?Cys?Ser?Met?Ala?Leu?Ala?Gly?Gly?Ala?Met?Val?Met?Ala
245 250 255
Thr?Pro?Gly?Asn?Phe?Val?Ala?Phe?Ser?Arg?Gln?Arg?Gly?Leu?Ala?Ala
260 265 270
Asp?Gly?Arg?Cys?Lys?Ala?Phe?Ala?Asp?Gly?Ala?Asp?Gly?Met?Gly?Leu
275 280 285
Ala?Glu?Gly?Val?Gly?Val?Val?Leu?Leu?Glu?Arg?Leu?Ser?Val?Ala?Arg
290 295 300
Lys?Arg?Gly?His?Lys?Val?Leu?Ala?Val?Leu?Arg?Gly?Ser?Ala?Val?Asn
305 310 315 320
Gln?Asp?Gly?Ala?Ser?Asn?Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln
325 330 335
Gln?Arg?Val?Ile?Arg?Arg?Ala?Leu?Ala?Ser?Ala?Gly?Val?Ser?Ala?Ala
340 345 350
Asp?Val?Asp?Val?Val?Glu?Ala?His?Gly?Thr?Gly?Thr?Ala?Leu?Gly?Asp
355 360 365
Pro?Ile?Glu?Ala?Gln?Ala?Leu?Leu?Ala?Thr?Tyr?Gly?Lys?Glu?Arg?Asp
370 375 380
Ala?Glu?Arg?Pro?Leu?Trp?Leu?Gly?Ser?Leu?Lys?Ser?Asn?Ile?Gly?His
385 390 395 400
Thr?Gln?Ala?Ala?Ala?Gly?Val?Gly?Ser?Val?Ile?Lys?Met?Val?Gln?Ala
405 410 415
Leu?Arg?His?Gly?Ile?Leu?Pro?Pro?Thr?Leu?His?Val?Asp?Ala?Pro?Thr
420 425 430
Thr?Glu?Val?Asp?Trp?Ser?Ala?Gly?Ala?Val?Glu?Leu?Leu?Thr?Glu?Ala
435 440 445
Arg?Glu?Trp?Pro?Arg?Glu?Asp?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser
450 455 460
Phe?Gly?Val?Ser?Gly?Thr?Asn?Ala?His?Leu?Ile?Leu?Glu?Glu?Ala?Pro
465 470 475 480
Ala?Glu?Glu?His?Ala?Pro?Gln?Pro?Leu?Pro?Ala?Gly?Gly?Gly?Gly?Val
485 490 495
Val?Pro?Leu?Val?Val?Ser?Ala?Arg?Ser?Ala?Gly?Ser?Leu?Ala?Gly?Gln
500 505 510
Ala?Gly?Arg?Leu?Ala?Ala?Phe?Val?Glu?Gly?Ala?Asp?Gly?Val?Pro?Leu
515 520 525
Ala?Ala?Val?Ala?Gly?Ala?Leu?Val?Ala?Gly?Arg?Ala?Val?Leu?Gly?Glu
530 535 540
Arg?Ala?Val?Val?Leu?Ala?Asp?Ser?Glu?Ala?Glu?Ala?Leu?Gly?Gly?Leu
545 550 555 560
Ser?Ala?Leu?Ala?Arg?Gly?Ala?Ser?Ala?Pro?Gly?Val?Val?Ser?Gly?Ser
565 570 575
Ala?Gly?Ser?Gly?Ala?Leu?Gly?Lys?Val?Val?Trp?Val?Phe?Pro?Gly?Gln
580 585 590
Gly?Ser?Gln?Trp?Ala?Gly?Met?Gly?Arg?Glu?Leu?Leu?Asp?Val?Ser?Pro
595 600 605
Val?Phe?Ala?Glu?Arg?Ile?Ala?Glu?Cys?Ala?Ala?Ala?Leu?Glu?Pro?Trp
610 615 620
Ile?Asp?Trp?Ser?Leu?Val?Asp?Val?Leu?Arg?Gly?Glu?Ala?Glu?Pro?Ala
625 630 635 640
Leu?Leu?Glu?Arg?Val?Asp?Val?Leu?Gln?Pro?Ala?Ser?Phe?Ala?Val?Met
645 650 655
Val?Gly?Leu?Ala?Ala?Val?Trp?Ser?Ser?Val?Gly?Val?Leu?Pro?Asp?Ala
660 665 670
Val?Val?Gly?His?Ser?Gln?Gly?Glu?Ile?Ala?Ala?Ala?Cys?Val?Ser?Gly
675 680 685
Ala?Leu?Ser?Leu?Glu?Asp?Ala?Ala?Arg?Val?Val?Ala?Leu?Arg?Ser?Gln
690 695 700
Ala?Ile?Ala?Gly?Gln?Leu?Ala?Gly?Arg?Gly?Gly?Met?Ala?Ser?Val?Ala
705 710 715 720
Leu?Ser?Glu?Ala?Asp?Ala?Ser?Ala?Arg?Leu?Thr?Arg?Trp?Ala?Asp?Arg
725 730 735
Val?Glu?Val?Ala?Ala?Val?Asn?Gly?Pro?Ser?Ser?Val?Val?Val?Ala?Gly
740 745 750
Asp?Ala?Glu?Ala?Leu?Asp?Glu?Ala?Leu?Glu?Ala?Leu?Ser?Ala?Asp?Gly
755 760 765
Val?Arg?Val?Arg?Arg?Val?Ala?Val?Asp?Tyr?Ala?Ser?His?Thr?Arg?His
770 775 780
Val?Glu?Asp?Ile?Arg?Glu?Ile?Leu?Ala?Asp?Thr?Leu?Ala?Glu?Val?Glu
785 790 795 800
Ala?Gln?Ala?Pro?Ser?Ile?Pro?Phe?Tyr?Ser?Thr?Val?Thr?Gly?Glu?Trp
805 810 815
Val?Glu?Asp?Ala?Gly?Val?Leu?Asp?Gly?Ala?Tyr?Trp?Tyr?Arg?Asn?Leu
820 825 830
Arg?Gly?Gln?Val?Gly?Phe?Gly?Pro?Ala?Val?Ala?Glu?Leu?Ile?Gly?Gln
835 840 845
Gly?His?Gly?Val?Phe?Val?Glu?Val?Ser?Ala?His?Pro?Val?Leu?Val?Gln
850 855 860
Pro?Ile?Thr?Glu?Ile?Leu?Asp?Asp?Gly?Thr?Asp?Ala?Leu?Ile?Thr?Gly
865 870 875 880
Ser?Leu?Arg?Arg?Asp?Asp?Gly?Gly?Leu?Arg?Arg?Leu?Leu?Ala?Ser?Met
885 890 895
Ala?Glu?Leu?Phe?Val?Arg?Gly?Val?Thr?Val?Asp?Trp?Thr?Gly?Val?Leu
900 905 910
Pro?Ala?Gly?Ala?Thr?Ser?Leu?Asp?Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe
915 920 925
Asp?His?Gln?His?Tyr?Trp?Leu?Gln?Ala?Thr?Asp?Ala?Gly?Pro?Val?Asp
930 935 940
Ala?Pro?Ser?Leu?Gly?Leu?Ala?Gly?Thr?Asp?His?Pro?Leu?Leu?Gly?Ala
945 950 955 960
Met?Val?Glu?Leu?Pro?His?Ser?Glu?Gly?Leu?Val?Phe?Thr?Ser?Arg?Leu
965 970 975
Ser?Leu?Lys?Ser?His?Pro?Trp?Leu?Ala?Asp?His?Ala?Ile?Gly?Gly?Met
980 985 990
Ala?Leu?Leu?Pro?Gly?Thr?Gly?Leu Val?Glu?Leu?Ala?Val Arg?Ala?Gly
995 1000 1005
Asp?Glu Ala?Gly?Cys?Gly?Val Leu?Glu?Glu?Leu?Val Ile?Glu?Ala
1010 1015 1020
Pro?Leu Val?Val?Pro?Glu?His Gly?Gly?Val?Arg?Val Gln?Val?Ala
1025 1030 1035
Val?Gly Ala?Pro?Gly?Glu?Asn Gly?Ser?Arg?Gly?Val Glu?Val?His
1040 1045 1050
Ser?Gln Arg?Asp?Gly?Val?Pro Gly?Glu?Gly?Asp?Ala Trp?Thr?Arg
1055 1060 1065
His?Ala Thr?Gly?Val?Leu?Ser Ser?Val?Pro?Ala?Ala Arg?Asp?Ser
1070 1075 1080
Asp?Phe Asp?Phe?Ala?Ala?Trp Pro?Pro?Pro?Gly?Ala Arg?Arg?Val
1085 1090 1095
Glu?Val Asp?Val?Ala?Gly?Phe Tyr?Asp?Asp?Leu?Arg Glu?Arg?Gly
1100 1105 1110
Val?Gly Tyr?Gly?Pro?Ala?Phe Gln?Gly?Val?Arg?Ala Val?Trp?Arg
1115 1120 1125
Arg?Gly Glu?Glu?Thr?Phe?Ala Glu?Val?Ala?Leu?Pro Glu?Glu?Leu
1130 1135 1140
His?Arg Glu?Ala?Ala?Gly?Phe Gly?Ile?His?Pro?Ala Leu?Leu?Asp
1145 1150 1155
Ala?Ala Leu?Gln?Thr?Gly?Thr Phe?Gly?Ala?Ala?Val Gly?Gly?Pro
1160 1165 1170
Gly?Glu Gly?Glu?Ala?Gly?Arg Pro?Val?Leu?Ala?Phe Ala?Trp?Asn
1175 1180 1185
Gly?Leu Val?Leu?His?Ala?Thr Gly?Ala?Ser?Ala?Leu Arg?Val?Arg
1190 1195 1200
Val?Ala Pro?Ser?Gly?Pro?Asp Gly?Leu?Ser?Val?Glu Ala?Ala?Asp
1205 1210 1215
Glu?Ser Gly?Ala?Leu?Val?Val Thr?Met?Asp?Ser?Leu Val?Ser?Arg
1220 1225 1230
Ala?Val Ser?Ala?Glu?Gln?Leu Asp?Thr?Ala?Ala?Gly Ser?Val?Ala
1235 1240 1245
Thr?Asp Ser?Leu?Tyr?Arg?Val Glu?Trp?Thr?Glu?Leu Pro?Pro?Ala
1250 1255 1260
Arg?Gly Pro?Glu?Pro?Val?Pro Thr?Trp?Ala?Ala?Val Arg?Thr?Pro
1265 1270 1275
Asp?Glu Ala?Gly?Ala?Leu?Ala Asp?Gly?Ala?Gly?Ala Pro?Gln?Ala
1280 1285 1290
Ala?Val Leu?Glu?Ala?Val?Gly Gly?Pro?Gly?Asp?Glu Ala?Val?Leu
1295 1300 1305
Ala?Leu Thr?Ser?Arg?Val?Leu Ala?Val?Val?Gln?Thr Trp?Leu?Ala
1310 1315 1320
Ala?Asp Gly?Leu?Asp?Ala?Ser Arg?Leu?Val?Val?Val Thr?Arg?Gly
1325 1330 1335
Ala?Val Pro?Ala?Asp?Gly?Glu Asp?Thr?Val?Thr?Asp Pro?Ala?Gly
1340 1345 1350
Ser?Ala Val?Trp?Gly?Leu?Val Arg?Ala?Val?Gln?Ala Glu?Asn?Pro
1355 1360 1365
Asp?Arg Val?Val?Leu?Met?Asp Ala?Gly?Pro?Ala?Ser Glu?Gly?Ala
1370 1375 1380
Ala?Gly Thr?Val?Pro?Gly?Ala Val?Leu?Ala?Ala?Val Leu?Ala?Ser
1385 1390 1395
Gly?Glu Pro?Gln?Val?Ala?Val Arg?Gly?Ala?Ala?Leu Thr?Val?Pro
1400 1405 1410
Arg?Leu Ala?Arg?Ala?Thr?Ala Gln?Asp?Val?Asp?Ala Asn?Pro?Val
1415 1420 1425
Phe?Arg Glu?Gln?Gly?Thr?Val Leu?Val?Ser?Gly?Gly Gly?Ser?Leu
1430 1435 1440
Gly?Glu Leu?Val?Thr?Arg?His Leu?Val?Val?Arg?His Gly?Val?Arg
1445 1450 1455
His?Leu Val?Leu?Ala?Ser?Arg Arg?Gly?Pro?Asp?Ala Glu?Gly?Val
1460 1465 1470
Asn?Glu Leu?Ala?Ala?Glu?Leu Thr?Gly?Leu?Gly?Ala Thr?Val?Ser
1475 1480 1485
Val?Val Ala?Cys?Asp?Met?Ser Asp?Arg?Ala?Gln?Val Glu?Ala?Leu
1490 1495 1500
Leu?Ala Arg?Thr?Gly?Gln?Glu Gln?Pro?Leu?Arg?Ala Val?Val?His
1505 1510 1515
Thr?Ala Gly?Val?Phe?Glu?Ala Gly?Leu?Val?Glu?Thr Leu?Thr?Pro
1520 1525 1530
Glu?Arg Leu?Ala?Arg?Val?Phe Ala?Pro?Lys?Val?Asp Ala?Val?Arg
1535 1540 1545
His?Leu Asp?Glu?Leu?Thr?Arg Asp?Leu?Ala?Leu?Asp Ala?Phe?Val
1550 1555 1560
Val?Tyr Ser?Ser?Ala?Ser?Ser Val?Phe?Met?Gly?Ala Gly?Ser?Ser
1565 1570 1575
Gly?Tyr Ala?Ala?Ala?Asn?Ala Tyr?Leu?Asp?Gly?Leu Met?Ser?Arg
1580 1585 1590
Arg?Arg Ala?Ala?Gly?Leu?Pro Gly?Leu?Ser?Leu?Ser Trp?Gly?Thr
1595 1600 1605
Trp?Ala His?Ala?Thr?Asn?Met Thr?Thr?His?Leu?Ser Thr?Asp?Asp
1610 1615 1620
Gln?Ala Arg?Met?Ser?Arg?Arg Ala?Asn?Arg?Asp?Gly Val?Val?Ala
1625 1630 1635
Leu?Thr Pro?Ala?Glu?Gly?Met Glu?Leu?Phe?Asp?Ala Ala?Val?Gly
1640 1645 1650
Ala?Ala Asp?Ala?Leu?Arg?Val Pro?Val?Lys?Leu?Asp Leu?Arg?Gly
1655 1660 1665
Val?Arg Ala?Ser?Ala?Ala?Ala Gly?Gly?Ala?Val?Pro His?Leu?Leu
1670 1675 1680
Arg?Gly Leu?Val?Pro?Leu?Thr Arg?Gln?Gln?Ala?Arg Ala?Ser?Ala
1685 1690 1695
Gly?Lys Asp?Gly?Asp?Leu?Leu Gly?Arg?Leu?Ser?Gly Leu?Pro?Gly
1700 1705 1710
Pro?Glu Gln?Glu?Ala?Leu?Leu Leu?Asp?Leu?Val?Arg Thr?Gln?Ala
1715 1720 1725
Ala?Val Val?Leu?Gly?His?Ser Gly?Pro?Glu?Ser?Val Lys?Ala?Glu
1730 1735 1740
Thr?Ala Phe?Lys?Asp?Val?Gly Phe?Asp?Ser?Leu?Thr Ser?Val?Glu
1745 1750 1755
Leu?Arg Asn?Arg?Leu?Arg?Glu Val?Thr?Gly?Arg?Lys Leu?Pro?Ala
1760 1765 1770
Thr?Leu Val?Phe?Asp?His?Pro Thr?Pro?Leu?Val?Leu Ala?Arg?Phe
1775 1780 1785
Leu?Arg Gly?Glu?Leu?Gly?Ile Gly?Asp?Asp?Val?Leu Ser?Arg?Val
1790 1795 1800
Thr?Thr Lys?Ile?Glu?Asp?Val?Glu?Ser?Leu?Leu?Gly Ala?Val?Ser
1805 1810 1815
Leu?Asp Glu?Ser?Met?Arg?Thr Ser?Ile?Ala?Leu?Arg Leu?Gln?Gly
1820 1825 1830
Leu?Val Ala?Arg?Cys?Asn?Gly Val?Val?Glu?Gln?Thr Asp?Gly?Ser
1835 1840 1845
Thr?Val Ala?Glu?Gln?Leu?Glu Ser?Ala?Ser?Ala?Asp Glu?Val?Leu
1850 1855 1860
Asp?Phe Ile?Asp?Gly?Glu?Leu Gly?Leu?Val
1865 1870
<210>6
<211>3591
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>6
Met?Ala?Thr?Asp?Glu?Lys?Leu?Leu?Lys?Tyr?Leu?Lys?Arg?Val?Thr?Thr
1 5 10 15
Glu?Leu?His?Thr?Leu?Arg?Lys?Gln?Gly?Ser?Ser?His?Ala?Gly?Glu?Pro
20 25 30
Ile?Ala?Ile?Val?Gly?Met?Ala?Cys?Arg?Leu?Pro?Gly?Gly?Val?Thr?Gly
35 40 45
Pro?Glu?Asp?Leu?Trp?Arg?Leu?Val?Arg?Glu?Gly?Gly?Asp?Ala?Val?Ser
50 55 60
Gly?Phe?Pro?Asp?Asp?Arg?Gly?Trp?Glu?Leu?Asp?Gly?Leu?Phe?Asp?Pro
65 70 75 80
Asp?Pro?Asp?Asn?Pro?Gly?Thr?Ser?Tyr?Thr?Asp?Gln?Gly?Gly?Phe?Leu
85 90 95
Lys?Gly?Ala?Gly?Leu?Phe?Asp?Pro?Gly?Phe?Phe?Gly?Ile?Ser?Pro?Arg
100 105 110
Glu?Ala?Leu?Ala?Met?Asp?Pro?Gln?Gln?Arg?Leu?Leu?Leu?Glu?Thr?Ser
115 120 125
Trp?Glu?Ala?Leu?Glu?Arg?Ala?Gly?Ile?Asp?Pro?Val?Ser?Leu?Lys?Gly
130 135 140
Thr?Asp?Val?Gly?Val?Phe?Ser?Gly?Val?Ser?Ser?Gln?Gly?Tyr?Gly?Ser
145 150 155 160
Gly?Ala?Gly?Gly?Val?Ala?Pro?Glu?Leu?Glu?Ser?Phe?Thr?Gly?Thr?Gly
165 170 175
Val?Ala?Ser?Ser?Val?Ala?Ser?Gly?Arg?Val?Ser?Tyr?Val?Phe?Gly?Phe
180 185 190
Glu?Gly?Pro?Ala?Val?Ser?Val?Asp?Thr?Ala?Cys?Ser?Ser?Ser?Leu?Val
195 200 205
Ala?Ile?His?Leu?Ala?Ala?Gln?Ala?Leu?Arg?Gln?Gly?Glu?Cys?Ser?Leu
210 215 220
Ala?Leu?Ala?Gly?Gly?Ala?Met?Val?Met?Ala?Thr?Pro?Gly?Thr?Phe?Val
225 230 235 240
Val?Phe?Ser?Arg?Gln?Gln?Gly?Met?Ala?Ala?Asp?Gly?Arg?Cys?Lys?Ala
245 250 255
Tyr?Ala?Asp?Gly?Ala?Asp?Gly?Met?Gly?Leu?Ala?Glu?Gly?Ala?Gly?Val
260 265 270
Ile?Val?Leu?Glu?Arg?Leu?Ser?Glu?Ala?Arg?Glu?Arg?Gly?His?Arg?Val
275 280 285
Leu?Ala?Val?Ile?Arg?Gly?Ser?Ala?Val?Asn?Gln?Asp?Gly?Ala?Ser?Asn
290 295 300
Gly?Leu?Thr?Ala?Pro?Asn?Gly?Pro?Ser?Gln?Gln?Arg?Val?Ile?Arg?Lys
305 310 315 320
Ala?Leu?Ala?Gly?Ala?Gly?Leu?Val?Ala?Ala?Asp?Val?Asp?Val?Val?Glu
325 330 335
Gly?His?Gly?Thr?Gly?Thr?Ala?Leu?Gly?Asp?Pro?Ile?Glu?Ala?Gln?Ala
340 345 350
Leu?Leu?Ala?Thr?Tyr?Gly?Gln?Gly?Arg?Asp?Pro?Glu?Arg?Pro?Leu?Trp
355 360 365
Leu?Gly?Ser?Leu?Lys?Ser?Asn?Ile?Gly?His?Thr?Gln?Ala?Ala?Ala?Gly
370 375 380
Val?Ser?Ser?Val?Ile?Lys?Met?Val?Glu?Ala?Leu?Arg?His?Arg?Val?Met
385 390 395 400
Pro?Pro?Thr?Leu?His?Ala?Glu?Glu?Pro?Thr?Ser?Glu?Val?Asp?Trp?Ser
405 410 415
Ala?Gly?Ala?Val?Glu?Leu?Leu?Thr?Glu?Ala?Arg?Glu?Trp?Pro?Ser?Asp
420 425 430
Gly?Arg?Pro?Arg?Arg?Ala?Gly?Val?Ser?Ser?Phe?Gly?Ile?Ser?Gly?Thr
435 440 445
Asn?Ala?His?Leu?Ile?Leu?Glu?Glu?Ala?Pro?Ala?Ala?Glu?Asp?Glu?Thr
450 455 460
Pro?Ala?Gly?Asp?Val?Thr?Ala?Thr?Pro?Gly?Ala?Asp?Glu?Thr?Pro?Gly
465 470 475 480
Ala?His?Glu?Thr?Ala?Gly?Ala?Glu?Ala?Thr?Ala?Gly?Ala?Ala?Gly?Ala
485 490 495
Gly?Leu?Val?Pro?Leu?Val?Val?Ser?Ala?His?Gly?Glu?Gly?Ser?Leu?Ala
500 505 510
Gly?Gln?Ala?Gly?Arg?Leu?Ala?Ala?Phe?Leu?Asp?Thr?Arg?Pro?Asp?Thr
515 520 525
Gly?Pro?Gly?Ser?Leu?Pro?Arg?Val?Ala?Gly?Ala?Leu?Leu?Ser?Glu?Arg
530 535 540
Ala?Leu?Leu?Arg?Glu?Arg?Ala?Val?Val?Leu?Ala?Ala?Thr?Asp?Gln?Glu
545 550 555 560
Ala?Ser?Ala?Gly?Leu?Gly?Ala?Leu?Ala?Arg?Gly?Glu?His?Ala?Ala?Gly
565 570 575
Thr?Val?Thr?Gly?Arg?Ala?Ala?Gly?Ala?Gly?Gly?Pro?Gly?Lys?Val?Val
580 585 590
Trp?Val?Phe?Pro?Gly?Gln?Gly?Ser?Gln?Arg?Ala?Gly?Ala?Gly?Arg?Glu
595 600 605
Leu?Tyr?Asp?Arg?Tyr?Pro?Val?Phe?Ala?Arg?Ala?Leu?Asp?Glu?Ala?Cys
610 615 620
Glu?Gln?Leu?Glu?Ala?Cys?Leu?Ala?Gly?Trp?Val?Asp?His?Pro?Val?Arg
625 630 635 640
Asp?Val?Val?Leu?Gly?Arg?Ser?Pro?Gly?Ser?Thr?Glu?Leu?Leu?Asn?Gln
645 650 655
Thr?Val?Phe?Thr?Gln?Ala?Ala?Leu?Phe?Ala?Val?Glu?Thr?Ala?Leu?Phe
660 665 670
Arg?Leu?Val?Glu?Ser?Trp?Gly?Val?Arg?Pro?Asp?Ala?Val?Ile?Gly?His
675 680 685
Ser?Ile?Gly?Glu?Val?Ser?Ala?Ala?His?Val?Ala?Gly?Val?Leu?Ser?Leu
690 695 700
Arg?Asp?Ala?Ala?Arg?Leu?Val?Ala?Ala?Arg?Gly?Arg?Leu?Met?Gln?Ala
705 710 715 720
Leu?Pro?Pro?Gly?Gly?Ala?Met?Val?Ala?Val?Ala?Ala?Gly?Glu?Ala?Glu
725 730 735
Val?Asp?Gly?Leu?Leu?Gly?Asp?Gly?Val?Glu?Ile?Ala?Ala?Val?Asn?Gly
740 745 750
Pro?Ala?Ala?Val?Val?Leu?Ser?Gly?Asp?Glu?Asp?Ala?Val?Leu?Ala?Ala
755 760 765
Ala?Gly?Arg?Leu?Arg?Glu?Gln?Gly?Arg?Lys?Thr?Lys?Arg?Leu?Val?Val
770 775 780
Ser?His?Ala?Phe?His?Ser?Leu?His?Met?Glu?Pro?Val?Leu?Ala?Asp?Phe
785 790 795 800
Ala?Ala?Glu?Leu?Thr?Asp?Val?Glu?Trp?Arg?Ala?Pro?Gln?Ile?Pro?Val
805 810 815
Ile?Ser?Asn?Val?Thr?Gly?Arg?Leu?Ala?Gly?Pro?Asp?Glu?Leu?Thr?Gly
820 825 830
Pro?Glu?Tyr?Trp?Ala?Gly?His?Val?Arg?Arg?Pro?Val?Arg?Phe?Ala?Glu
835 840 845
Gly?Ile?Ala?Ala?Ala?Val?Gln?Tyr?Gly?Gly?Thr?Leu?Phe?Val?Glu?Leu
850 855 860
Gly?Pro?Gly?Ala?Ala?Leu?Thr?Gly?Leu?Val?Thr?Glu?Thr?Ala?Ala?Ser
865 870 875 880
Ala?Val?Pro?Asp?Thr?Thr?Ser?Gly?Pro?Gly?Val?Thr?Cys?Val?Ala?Ala
885 890 895
Leu?Arg?Asp?Gly?Arg?Pro?Glu?Glu?Arg?Thr?Leu?Leu?Ala?Ser?Met?Ala
900 905 910
Glu?Leu?Phe?Val?Arg?Gly?Val?Ser?Val?Asp?Trp?Ala?Arg?Val?Leu?Pro
915 920 925
Asp?Thr?Gly?Thr?Gly?Thr?Ala?Val?Val?Asp?Leu?Pro?Thr?Tyr?Ala?Phe
930 935 940
Asp?His?Gln?Gln?Tyr?Trp?Leu?Arg?Thr?Ala?Arg?Ser?Val?Thr?Asp?Ala
945 950 955 960
Ala?Ser?Leu?Gly?Gln?Ala?Ala?Ala?Asp?His?Pro?Leu?Leu?Gly?Ala?Val
965 970 975
Val?Arg?Leu?Pro?His?Ser?Asp?Gly?Leu?Val?Cys?Thr?Ser?Arg?Leu?Ser
980 985 990
Leu?Lys?Thr?His?Pro?Trp?Leu?Ala Asp?His?Thr?Val?Gly Gly?Ala?Val
995 1000 1005
Leu?Val Pro?Gly?Thr?Gly?Leu Val?Glu?Leu?Ala?Val Arg?Ala?Gly
1010 1015 1020
Asp?Glu Ala?Asp?Cys?Gly?Ile Leu?Glu?Glu?Leu?Val Ile?Glu?Ala
1025 1030 1035
Pro?Leu Val?Val?Pro?Glu?His Gly?Gly?Val?Arg?Val Gln?Val?Ala
1040 1045 1050
Val?Gly Ala?Pro?Asp?Arg?Asn Gly?Ala?Arg?Thr?Val Glu?Ile?His
1055 1060 1065
Ser?Gln Arg?Glu?Asp?Ala?Pro Asp?Ala?Gly?Asp?Ala Trp?Thr?Arg
1070 1075 1080
His?Ala Thr?Ala?Thr?Leu?Ala Ala?Thr?Arg?Thr?Ala Ala?Pro?Ala
1085 1090 1095
Ala?Arg Asp?Ser?Asp?Phe?Asp Phe?Thr?Ala?Trp?Pro Pro?Pro?Gly
1100 1105 1110
Ala?Gln Pro?Val?Gly?Thr?Gly Asp?Phe?Tyr?Gly?Gly Leu?Ser?Glu
1115 1120 1125
Arg?Gly Tyr?Gly?Tyr?Gly?Pro Ala?Phe?Gln?Gly?Leu Arg?Ala?Val
1130 1135 1140
Trp?Arg Arg?Gly?Asp?Glu?Val Phe?Ala?Glu?Ala?Ala Leu?Pro?Ala
1145 1150 1155
Glu?His Arg?Glu?Asp?Ala?Asp Arg?Phe?Gly?Ile?His Pro?Ala?Leu
1160 1165 1170
Leu?Asp Ala?Ala?Leu?His?Ala Gly?Met?Phe?Gly?Ala Glu?Ala?Asp
1175 1180 1185
Ala?Ala Ala?His?Asp?Pro?Gly Gln?Pro?Val?Leu?Pro Phe?Ala?Trp
1190 1195 1200
Asn?Gly Leu?Glu?Leu?His?Ala Ala?Gly?Ala?Pro?Ala Leu?Arg?Ile
1205 1210 1215
Arg?Leu Thr?Ser?Ala?Gly?Pro Gly?Ala?Val?Ala?Leu Glu?Ala?Ala
1220 1225 1230
Asp?Glu Thr?Gly?Gly?Leu?Val Val?Thr?Leu?Asp?Ser Leu?Val?Ser
1235 1240 1245
Arg?Pro Val?Ser?Ala?Asp?Gln Leu?Ala?Pro?Val?Pro Ala?Ser?Ala
1250 1255 1260
Ala?Thr Asp?Ala?Leu?Phe?Arg Val?Asp?Trp?Thr?Glu Met?Thr?Pro
1265 1270 1275
Asp?Arg Ser?Leu?Pro?Pro?Ala Pro?Ala?Trp?Ala?Pro Val?Ala?Thr
1280 1285 1290
Ala?Glu Asp?Val?Ala?Asp?Leu Ala?Arg?Ser?Gly?Ala Pro?Ala?Met
1295 1300 1305
Ala?Val Leu?Asp?Ala?Val?Thr Thr?Gly?Asp?Asp?Gly Ala?Asp?Ala
1310 1315 1320
Val?Leu Ala?Leu?Thr?Ser?Arg Val?Leu?Gly?Val?Val Gln?Ala?Trp
1325 1330 1335
Leu?Ala Thr?Asp?Gly?Leu?Asp Glu?Ser?Arg?Leu?Val Val?Ala?Thr
1340 1345 1350
Arg?Gly Ala?Val?Pro?Ala?Gly Asp?Glu?Gly?Ala?Val Thr?Asp?Pro
1355 1360 1365
Ala?Gly Ala?Ala?Val?Trp?Gly Leu?Val?Arg?Ala?Ala Gln?Ala?Glu
1370 1375 1380
Asn?Pro Asp?Arg?Leu?Val?Leu Val?Asp?Ala?Asp?Pro Ala?Ala?Asp
1385 1390 1395
Asp?Gly Val?Val?Pro?Val?Leu Gly?Val?Val?Arg?Ala Ala?Gly?Glu
1400 1405 1410
Pro?Gln Ala?Ala?Val?Arg?Gly Pro?Ala?Leu?Arg?Val Pro?Arg?Leu
1415 1420 1425
Ala?Arg Ala?Gly?Gly?Pro?Ala Pro?Asp?Thr?Pro?Arg Val?Phe?Asp
1430 1435 1440
Pro?Glu Gly?Thr?Val?Leu?Ile Thr?Gly?Gly?Thr?Gly Ser?Leu?Gly
1445 1450 1455
Gly?Leu Met?Ala?Arg?His?Leu Val?Thr?Arg?His?Gly Val?Arg?His
1460 1465 1470
Leu?Val Leu?Ala?Gly?Arg?Arg Gly?Pro?Asp?Ala?Glu Gly?Ala?Gln
1475 1480 1485
Glu?Leu Ala?Ala?Glu?Leu?Thr Glu?Leu?Gly?Ala?Ala Val?Glu?Val
1490 1495 1500
Val?Ala Cys?Asp?Val?Ser?Asp Arg?Ala?Gln?Thr?Glu Ala?Leu?Leu
1505 1510 1515
Gly?Arg Ile?Pro?Gly?Glu?His Pro?Leu?Arg?Gly?Val Val?His?Thr
1520 1525 1530
Ala?Gly Val?Leu?Asp?Asp?Gly Val?Ile?Gly?Ala?Leu Thr?Pro?Glu
1535 1540 1545
Arg?Leu Gly?Lys?Val?Phe?Ala Pro?Lys?Val?Asp?Ala Val?Arg?His
1550 1555 1560
Leu?Asp Ala?Leu?Thr?Arg?Gly Leu?Asp?Leu?Asp?Ala Phe?Val?Val
1565 1570 1575
Phe?Ser Ser?Ala?Ser?Gly?Val Phe?Gly?Ser?Ala?Gly Gln?Gly?Asn
1580 1585 1590
Tyr?Ala Ala?Ala?Asn?Ala?Phe Leu?Asp?Gly?Leu?Met Ala?Thr?Arg
1595 1600 1605
Arg?Glu Ala?Gly?Leu?Pro?Gly Leu?Ser?Leu?Ala?Trp Gly?Leu?Trp
1610 1615 1620
Glu?Gln Asp?Ala?Gly?Met?Thr Ala?His?Leu?Gly?Asp Ala?Asp?Gln
1625 1630 1635
Ala?Arg Ala?Gly?Arg?Gly?Gly Val?Leu?Ala?Ile?Thr Ala?Thr?Glu
1640 1645 1650
Gly?Thr Glu?Leu?Phe?Asp?Ala Ala?Leu?Val?Ser?Gly Gln?Ala?Leu
1655 1660 1665
Leu?Val Pro?Ile?Lys?Met?Asp Leu?Ala?Ala?Ala?Arg Ala?Gly?Ala
1670 1675 1680
Ala?Thr Gly?Ala?Ala?Val?Pro His?Leu?Leu?Arg?Gly Leu?Val?Pro
1685 1690 1695
Ala?Gly Arg?Arg?Gln?Ala?Arg Ala?Ala?Ala?Gly?Thr Gly?Asp?Glu
1700 1705 1710
Leu?Pro Arg?Arg?Leu?Ser?Ala Leu?Thr?Gly?Pro?Glu Gln?Asp?Ala
1715 1720 1725
Leu?Leu Leu?Asp?Leu?Val?Arg Thr?Gln?Ala?Ala?Val Val?Leu?Gly
1730 1735 1740
His?Ser Gly?Pro?Asp?Ser?Val Arg?Ala?Asp?Thr?Ala Phe?Asn?Glu
1745 1750 1755
Ala?Gly Phe?Asp?Ser?Leu?Thr Ser?Val?Glu?Leu?Arg Asn?Arg?Leu
1760 1765 1770
Arg?Glu Ala?Thr?Gly?Leu?Lys Leu?Pro?Ala?Thr?Leu Ile?Phe?Asp
1775 1780 1785
Tyr?Pro Asn?Pro?Gln?Ala?Leu Ala?Gly?Phe?Leu?Arg Glu?Glu?Phe
1790 1795 1800
Gly?Asp Thr?Thr?Ala?Thr?Ser Gly?Ala?Pro?Ala?Pro Ser?Thr?Ala
1805 1810 1815
Ala?Ala Asp?Pro?Asp?Glu?Pro Ile?Ala?Val?Val?Gly Met?Ser?Cys
1820 1825 1830
Lys?Leu Pro?Gly?Gly?Val?Thr Ser?Pro?Asp?Asp?Leu Trp?Arg?Leu
1835 1840 1845
Val?Ser Glu?Gly?Arg?Glu?Gly Thr?Ser?Ala?Phe?Pro Gly?Asp?Arg
1850 1855 1860
Gly?Trp Asp?Leu?Glu?Gly?Leu Phe?Asp?Ala?Asp?Pro Glu?Ser?Ala
1865 1870 1875
Gly?Thr Ser?Tyr?Thr?Ser?Arg Gly?Gly?Phe?Val?Gln Glu?Ala?Gly
1880 1885 1890
Leu?Phe Asp?Ala?Gly?Phe?Phe Gly?Ile?Ser?Pro?Arg Glu?Ala?Leu
1895 1900 1905
Ala?Met Asp?Pro?Gln?Gln?Arg Leu?Leu?Leu?Glu?Thr Ser?Trp?Glu
1910 1915 1920
Ala?Phe Glu?Asn?Ala?Gly?Ile Asp?Pro?Leu?Ser?Leu Lys?Gly?Thr
1925 1930 1935
Asp?Val Gly?Val?Phe?Ser?Gly Val?Ser?Ser?Gln?Gly Tyr?Gly?Ala
1940 1945 1950
Gly?Val Thr?Ala?Pro?Glu?Leu Glu?Gly?Phe?Ala?Ser Thr?Gly?Thr
1955 1960 1965
Ala?Ser Ser?Val?Ala?Ser?Gly Arg?Val?Ser?Tyr?Val Phe?Gly?Phe
1970 1975 1980
Glu?Gly Pro?Ala?Val?Thr?Val Asp?Thr?Ala?Cys?Ser Ser?Ser?Leu
1985 1990 1995
Val?Ala Met?His?Leu?Ala?Ala Gln?Ala?Leu?Arg?Gln Gly?Glu?Cys
2000 2005 2010
Ser?Met Ala?Leu?Ala?Gly?Gly Val?Thr?Val?Met?Ala Thr?Pro?Val
2015 2020 2025
Ser?Phe Val?Glu?Phe?Ser?Arg Gln?Arg?Gly?Leu?Ala Gly?Asp?Gly
2030 2035 2040
Arg?Cys Lys?Ala?Tyr?Ala?Asp Gly?Ala?Asp?Gly?Thr Gly?Trp?Ala
2045 2050 2055
Glu?Gly Ile?Gly?Leu?Ile?Val Leu?Glu?Arg?Leu?Ser Val?Ala?Arg
2060 2065 2070
Glu?Arg Gly?His?Lys?Ile?Leu Ala?Val?Leu?Arg?Gly Ser?Ala?Val
2075 2080 2085
Asn?Gln Asp?Gly?Ala?Ser?Asn Gly?Leu?Thr?Ala?Pro Asn?Gly?Pro
2090 2095 2100
Ser?Gln Gln?Arg?Val?Ile?Arg Arg?Ala?Leu?Ala?Ser Ala?Gly?Leu
2105 2110 2115
Ser?Ala Ala?Asp?Val?Asp?Val Val?Glu?Gly?His?Gly Thr?Gly?Thr
2120 2125 2130
Ala?Leu Gly?Asp?Pro?Ile?Glu Ala?Gln?Ala?Leu?Leu Ala?Thr?Tyr
2135 2140 2145
Gly?Lys Asp?Arg?Asp?Pro?Arg Gln?Pro?Leu?Trp?Leu Gly?Ser?Leu
2150 2155 2160
Lys?Ser Asn?Ile?Gly?His?Thr Gln?Ala?Ala?Ala?Gly Val?Ala?Gly
2165 2170 2175
Val?Ile Lys?Met?Val?Gln?Ala Leu?Arg?His?Arg?Ile Met?Pro?Pro
2180 2185 2190
Thr?Leu His?Val?Asp?Ala?Pro Ser?Ser?Arg?Val?Asp Trp?Ser?Ala
2195 2200 2205
Gly?Ala Val?Glu?Leu?Leu?Thr Glu?Ala?Arg?Glu?Trp Pro?Arg?Asp
2210 2215 2220
Gly?Arg Pro?Arg?Arg?Ala?Gly Val?Ser?Ser?Phe?Gly Ile?Ser?Gly
2225 2230 2235
Thr?Asn Ala?His?Leu?Ile?Leu Glu?Glu?Ala?Pro?Glu Glu?Val?Ala
2240 2245 2250
Ala?Pro Pro?Val?Ser?Ser?Ala Gly?Val?Val?Pro?Leu Val?Val?Ser
2255 2260 2265
Ala?Arg Ser?Ala?Gly?Ser?Leu Ala?Gly?Gln?Ala?Gly Arg?Leu?Ala
2270 2275 2280
Thr?Phe Val?Glu?Gly?Thr?Asp Gly?Val?Pro?Leu?Ala Ser?Val?Ala
2285 2290 2295
Gly?Ala Leu?Val?Ala?Gly?Arg Ala?Val?Leu?Ser?Glu Arg?Ala?Val
2300 2305 2310
Val?Val Ala?Asp?Ser?Asp?Thr Glu?Ala?Val?Ala?Gly Leu?Arg?Ala
2315 2320 2325
Leu?Glu Arg?Gly?Glu?Ser?Pro Ala?Gly?Leu?Val?Thr Gly?Arg?Val
2330 2335 2340
Ser?Gly Ser?Gly?Ala?Pro?Gly Lys?Val?Val?Trp?Val Phe?Pro?Gly
2345 2350 2355
Gln?Gly Ser?Gln?Trp?Ala?Gly Met?Gly?Arg?Glu?Leu Leu?Asp?Ala
2360 2365 2370
Ser?Pro Val?Phe?Ala?Glu?Arg Ile?Ala?Glu?Cys?Ala Ala?Ala?Leu
2375 2380 2385
Glu?Pro Trp?Ile?Asp?Trp?Ser Leu?Val?Asp?Val?Leu Arg?Gly?Glu
2390 2395 2400
Val?Glu Pro?Ala?Leu?Leu?Glu Arg?Val?Asp?Val?Leu Gln?Pro?Ala
2405 2410 2415
Ser?Phe Ala?Val?Met?Val?Gly Leu?Ala?Ala?Val?Trp Ser?Ser?Val
2420 2425 2430
Gly?Val Leu?Pro?Asp?Ala?Val Val?Gly?His?Ser?Gln Gly?Glu?Ile
2435 2440 2445
Ala?Ala Ala?Cys?Val?Ser?Gly Ala?Leu?Ser?Leu?Glu Asp?Ala?Ala
2450 2455 2460
Arg?Val Val?Ala?Leu?Arg?Ser Gln?Ala?Ile?Ala?Gly Gln?Leu?Ala
2465 2470 2475
Gly?Arg Gly?Gly?Met?Ala?Ser Val?Ala?Leu?Ser?Glu Ala?Asp?Val
2480 2485 2490
Val?Ala Arg?Leu?Glu?Arg?Trp Ala?Asp?Arg?Val?Glu Val?Ala?Ala
2495 2500 2505
Val?Asn Gly?Pro?Ser?Ser?Val Val?Val?Ala?Gly?Asp Ala?Glu?Ala
2510 2515 2520
Leu?Asp Glu?Ala?Leu?Glu?Ala Leu?Ser?Ala?Glu?Gly Val?Arg?Val
2525 2530 2535
Arg?Arg Val?Ala?Val?Asp?Tyr Ala?Ser?His?Thr?Arg His?Val?Glu
2540 2545 2550
Asp?Ile Arg?Glu?Ile?Leu?Ala Asp?Thr?Leu?Ala?Gly Val?Asn?Ala
2555 2560 2565
Gln?Ala Pro?Met?Val?Pro?Phe Tyr?Ser?Thr?Val?Thr Gly?Glu?Trp
2570 2575 2580
Val?Glu Asp?Ala?Gly?Val?Leu Asp?Gly?Ala?Tyr?Trp Tyr?Arg?Asn
2585 2590 2595
Leu?Arg Gly?Gln?Val?Gly?Phe Gly?Pro?Ala?Val?Thr Asp?Leu?Leu
2600 2605 2610
Ser?Gln Gly?His?Arg?Thr?Phe Val?Glu?Val?Ser?Ala His?Pro?Val
2615 2620 2625
Leu?Val Gln?Pro?Val?Thr?Glu Ile?Leu?Asp?Glu?Ser Asp?Ala?Ala
2630 2635 2640
Pro?Gly Thr?Val?Val?Thr?Gly Ser?Leu?Arg?Arg?Asp Asp?Gly?Gly
2645 2650 2655
Leu?Arg Arg?Leu?Leu?Ala?Ser Met?Ala?Glu?Leu?Phe Val?Arg?Gly
2660 2665 2670
Val?Pro Val?Asp?Trp?Thr?Gly Val?Leu?Pro?Ala?Gly Ala?Thr?Ser
2675 2680 2685
Ala?Arg Leu?Glu?Leu?Pro?Thr Tyr?Ala?Phe?Asp?His Gln?His?Tyr
2690 2695 2700
Trp?Leu Gln?Ala?Thr?Asp?Ala Gly?Pro?Val?Asp?Ala Thr?Ser?Leu
2705 2710 2715
Gly?Leu Ala?Gly?Thr?Asp?His Pro?Leu?Leu?Gly?Ala Met?Val?Glu
2720 2725 2730
Leu?Pro Tyr?Ser?Asp?Gly?Leu Val?Phe?Thr?Ser?Arg Leu?Ser?Leu
2735 2740 2745
Lys?Ser Gln?Pro?Trp?Leu?Ala Asp?His?Arg?Val?Gly Gly?Val?Val
2750 2755 2760
Leu?Val Pro?Gly?Thr?Gly?Leu Val?Glu?Leu?Ala?Val Arg?Ala?Gly
2765 2770 2775
Asp?Glu Ala?Gly?Cys?Gly?Val Leu?Glu?Glu?Leu?Val Ile?Glu?Ala
2780 2785 2790
Pro?Leu Val?Val?Pro?Glu?His Gly?Gly?Val?Arg?Val Gln?Val?Ala
2795 2800 2805
Val?Gly Ala?Pro?Gly?Glu?Asn Gly?Ala?Arg?Thr?Val Asp?Val?Tyr
2810 2815 2820
Ser?Arg Pro?Glu?Asp?Ala?Gly Ser?Leu?Arg?Ser?Gly Ala?Asp?Ala
2825 2830 2835
Trp?Thr Arg?His?Ala?Thr?Gly Met?Leu?Ala?Gly?Thr Pro?Gln?Pro
2840 2845 2850
Gly?Ser Arg?Ala?Ala?Glu?Phe Asp?Phe?Ala?Ala?Trp Pro?Pro?Pro
2855 2860 2865
Gly?Ala Gln?Pro?Val?Asp?Val Ala?Gly?Gly?Tyr?Gly Leu?Leu?Thr
2870 2875 2880
Glu?Val Gly?Tyr?Gly?Tyr?Gly Pro?Ala?Phe?Gln?Gly Val?Arg?Ala
2885 2890 2895
Leu?Trp Arg?Arg?Gly?Asp?Glu Ile?Phe?Ala?Glu?Val Ala?Leu?Pro
2900 2905 2910
Glu?Glu His?Arg?Ala?Asp?Ala Ala?Arg?Phe?Gly?Ile His?Pro?Ala
2915 2920 2925
Leu?Leu Asp?Ala?Ala?Leu?His Ser?Pro?Leu?Leu?Gln Ile?Ala?Gly
2930 2935 2940
Ala?Asp Ala?Gly?Asp?Gly?Ala Ala?Glu?Ala?Ala?Pro Gly?Gly?Pro
2945 2950 2955
Glu?Leu Arg?Leu?Pro?Phe?Ala Trp?Asn?Gly?Leu?Val Leu?His?Ala
2960 2965 2970
Ala?Gly Ala?Ser?Val?Leu?Arg Val?Arg?Val?Ala?Arg Ser?Glu?His
2975 2980 2985
Asp?Ala Leu?Ser?Leu?Ala?Ala Ala?Asp?Glu?Thr?Gly Ala?Pro?Val
2990 2995 3000
Val?Thr Met?Asp?Ser?Leu?Val Ser?Arg?Val?Val?Ser Ala?Asp?Gln
3005 3010 3015
Leu?Glu Thr?Ala?Ala?Gly?Thr Thr?Arg?Ala?Asp?Ser Leu?Phe?Arg
3020 3025 3030
Val?Glu Trp?Thr?Glu?Leu?Leu Pro?Leu?Leu?Gly?Thr Glu?Thr?Val
3035 3040 3045
Pro?Ser Trp?Ser?Pro?Val?Ser Thr?Ala?Glu?Glu?Val Ala?Thr?Leu
3050 3055 3060
Ala?Asp Asp?Val?Glu?Ser?Gly Ala?Pro?Ala?Pro?Ala Leu?Ala?Val
3065 3070 3075
Leu?Glu Ala?Ile?Gly?Gly?Glu Gly?Ala?Asp?Ala?Ala Leu?Asp?Leu
3080 3085 3090
Ala?Thr Arg?Val?Leu?Glu?Ala Val?Gln?Cys?Trp?Leu Asp?Gly?Pro
3095 3100 3105
Gly?Leu Glu?Glu?Thr?Arg?Leu Ala?Val?Val?Thr?Arg Gly?Ala?Val
3110 3115 3120
Pro?Ala Gly?Gly?Glu?Glu?Thr Val?Thr?Asp?Pro?Ala Gly?Ser?Ala
3125 3130 3135
Val?Trp Gly?Leu?Val?Arg?Ala Ala?Gln?Ala?Glu?Asn Pro?Asp?Arg
3140 3145 3150
Ile?Leu Leu?Ile?Asp?Thr?Asp Pro?Ala?Gly?Thr?Ala Pro?Val?Glu
3155 3160 3165
Ala?Ala Val?Thr?Ala?Leu?Gly Val?Ala?Leu?Ala?Gly Gly?Glu?Pro
3170 3175 3180
Gln?Val Ala?Val?Arg?Gly?Gly Val?Leu?Ser?Val?Pro Arg?Leu?Val
3185 3190 3195
Arg?Ala Gly?Val?Gln?Gly?Thr Asp?Pro?Asp?Thr?Ala Phe?Gly?Pro
3200 3205 3210
Asp?Gly Thr?Val?Leu?Val?Ser Gly?Ala?Gly?Ser?Leu Gly?Gly?Leu
3215 3220 3225
Val?Ala Arg?His?Leu?Val?Ser Arg?His?Gly?Val?Arg His?Leu?Val
3230 3235 3240
Leu?Ala Ser?Arg?Arg?Gly?Pro Asp?Ala?Glu?Gly?Val Pro?Glu?Leu
3245 3250 3255
Val?Ala Glu?Leu?Ala?Gly?Gln Gly?Ala?Ala?Val?Glu Val?Val?Ala
3260 3265 3270
Cys?Asp Val?Ser?Asp?Arg?Ala Gln?Val?Glu?Ala?Leu Leu?Ala?Thr
3275 3280 3285
Val?Ser Asp?Ala?His?Pro?Leu Arg?Gly?Val?Val?His Thr?Ala?Gly
3290 3295 3300
Val?Thr Asp?Asp?Gly?Val?Ile Gly?Ala?Leu?Thr?Pro Glu?Arg?Leu
3305 3310 3315
Ala?Arg Val?Phe?Ala?Pro?Lys Val?Asp?Ala?Val?Arg His?Leu?Asp
3320 3325 3330
Glu?Leu Thr?Arg?Gly?Leu?Asp Leu?Asp?Ala?Phe?Val Val?Tyr?Ser
3335 3340 3345
Ser?Val Ser?Ala?Val?Phe?Met Gly?Ala?Gly?Ser?Gly Ser?Tyr?Ala
3350 3355 3360
Ala?Ala Asn?Ala?Tyr?Leu?Asp Gly?Leu?Met?Ala?Ala Arg?Arg?Gly
3365 3370 3375
Ala?Gly Leu?Pro?Gly?Leu?Ser Leu?Ala?Trp?Gly?Leu Trp?Glu?Gln
3380 3385 3390
Thr?Ser Gly?Met?Ala?Ala?Asn Thr?Asp?Asp?Leu?Thr Arg?Ser?Arg
3395 3400 3405
Met?Asn Arg?Arg?Gly?Gly?Leu Gln?Ala?Ile?Thr?Pro Ala?Glu?Gly
3410 3415 3420
Met?Glu Leu?Phe?Asp?Ala?Ala Val?Arg?Ser?Gly?Gln Ala?Gln?Leu
3425 3430 3435
Val?Pro Ala?Lys?Leu?Asp?Leu Ala?Ser?Leu?Arg?Thr Arg?Ala?Thr
3440 3445 3450
Asp?Gly Gly?Gly?Val?Pro?His Leu?Leu?Arg?Gly?Leu Val?Arg?Ala
3455 3460 3465
Gly?Arg Gln?Thr?Ala?His?Thr Ala?Ser?Val?Gly?Asp Gln?Gly?Lys
3470 3475 3480
Ala?Leu Ser?Glu?Arg?Leu?Ala Ala?Leu?Pro?Ala?Ala Glu?Gln?Ala
3485 3490 3495
Glu?Leu Leu?Leu?Asp?Val?Val Arg?Asp?Gln?Val?Ala Ala?Val?Leu
3500 3505 3510
Gly?His Ser?Ala?Thr?Phe?Arg Ile?Asp?Ala?Asp?Gln Gly?Leu?Phe
3515 3520 3525
Glu?Val Gly?Phe?Asp?Ser?Leu Thr?Ser?Ile?Glu?Leu Arg?Asn?Arg
3530 3535 3540
Leu?Arg Asp?Leu?Thr?Glu?Arg Lys?Leu?Pro?Pro?His Leu?Val?Phe
3545 3550 3555
Asp?His Pro?Thr?Ala?Ala?Ser Leu?Ala?Ala?Tyr?Leu His?Arg?Leu
3560 3565 3570
Val?Cys Gly?Glu?Gln?Ala?Ala Leu?Ala?Val?Ala?Gly Pro?Val?Ala
3575 3580 3585
Val?Ser?Val
3590
<210>7
<211>259
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>7
Val?Phe?Asp?Val?Asp?Arg?Tyr?Leu?Ala?Arg?Ile?Gly?Cys?Ala?Gly?Glu
1 5 10 15
Thr?Gly?Val?Asp?Ile?Ala?Thr?Leu?Arg?Lys?Leu?His?Arg?Asn?His?Leu
20 25 30
Met?Ala?Ile?Pro?Tyr?Asn?Gly?Ala?Thr?Gln?Asp?Phe?Ala?Asp?Gly?Val
35 40 45
Arg?Leu?Val?Asp?Leu?Asp?Glu?Asp?Ala?Thr?Phe?Glu?Thr?Cys?Val?Ile
50 55 60
Gln?Gly?Arg?Gly?Gly?Thr?Cys?Phe?Gln?Leu?Asn?Arg?Leu?Phe?Ser?Arg
65 70 75 80
Leu?Leu?Thr?Glu?Leu?Gly?His?Asp?Val?Thr?Leu?Leu?Ala?Ala?Ser?Thr
85 90 95
Ala?Glu?Gly?Arg?Glu?Ala?Ser?Gly?Leu?Asp?Val?Glu?His?Met?Phe?Asn
100 105 110
Arg?Val?Ala?Leu?Asp?Gly?Ala?Asp?Trp?Leu?Val?Asp?Val?Gly?Tyr?Pro
115 120 125
Gly?Pro?Ser?Tyr?Val?Glu?Pro?Leu?Leu?Val?Thr?Asp?Ala?Val?Gln?Ser
130 135 140
Gln?Tyr?Gly?Cys?Gln?Tyr?Arg?Leu?Val?Asp?Arg?Gly?Ser?Arg?Thr?Ala
145 150 155 160
Leu?Gln?Arg?Arg?Gly?Arg?Ile?Thr?Arg?Trp?Ser?Val?Val?Tyr?Thr?Phe
165 170 175
Thr?Pro?Gln?Ala?Arg?Gln?Trp?Ser?Asp?Trp?Lys?Glu?Met?Glu?Glu?Phe
180 185 190
Leu?Val?Arg?Glu?Ile?Ala?Ala?Asp?Thr?Gly?Pro?Arg?Asp?Gly?Arg?Asn
195 200 205
Ile?Leu?Cys?Gly?Arg?Thr?Leu?Asp?Asn?Gly?Gln?Ala?Val?Leu?Lys?Gly
210 215 220
Arg?Arg?Tyr?Leu?Thr?Val?Arg?Asp?Gly?Arg?Glu?Glu?Ile?Arg?Thr?Ile
225 230 235 240
Thr?Asp?Asp?Asp?Glu?His?Gln?Arg?Leu?Val?Ser?His?Leu?Leu?Ser?Asp
245 250 255
Ala?Phe?Gly
<210>8
<211>416
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>8
Val?Leu?Leu?Glu?Lys?Glu?Leu?Ser?Ser?Arg?Phe?His?Ile?Gly?Glu?Ser
1 5 10 15
Leu?Leu?Pro?Tyr?Met?Met?Gly?Leu?Phe?Glu?Arg?Ile?Gly?Leu?Arg?Glu
20 25 30
Thr?Val?Ala?Ala?Gln?Gly?Tyr?Val?Pro?Lys?Phe?Gly?Gly?Glu?Phe?Ile
35 40 45
Asp?Pro?Thr?Glu?Lys?Lys?Phe?Phe?Glu?Gly?Val?Phe?Arg?Ala?Asp?Phe
50 55 60
Thr?Lys?Gln?Gly?Val?Gly?Arg?His?Asp?Asn?Ala?Phe?Gln?Val?Glu?Arg
65 70 75 80
Ala?Lys?Phe?Asp?Arg?Met?Leu?Ala?Glu?Gln?Ala?Glu?Ala?Ala?Gly?Ala
85 90 95
Arg?Val?Leu?Phe?Gly?Ala?Ash?Val?Asn?Glu?Leu?Leu?Met?Asp?Gly?Asp
100 105 110
Arg?Met?Val?Gly?Val?Arg?Tyr?Glu?Arg?Asp?Gly?Glu?Ser?His?Glu?Val
115 120 125
Ser?Ser?Ala?Tyr?Val?Val?Asp?Ala?Ser?Gly?Arg?Ser?Gly?Arg?Ile?Ala
130 135 140
Asn?Arg?Phe?Gly?Leu?Arg?Lys?Thr?Leu?Glu?Lys?Leu?Arg?Met?Val?Ala
145 150 155 160
Val?Phe?Arg?His?Tyr?Ser?Gly?Leu?Asp?Glu?Arg?His?Asn?Pro?Gly?Val
165 170 175
Glu?Gly?Asp?Ile?Gln?Val?Gly?Ala?His?Asp?Asp?Gly?Trp?Val?Trp?Ala
180 185 190
Ile?Pro?Leu?Thr?Lys?Asp?Thr?Ile?Ser?Val?Gly?Thr?Val?Met?Pro?Arg
195 200 205
Asp?Val?Leu?Arg?Gly?Ala?Thr?Thr?Gln?Glu?Arg?Phe?Asp?Glu?His?Leu
210 215 220
Ala?Arg?Val?Pro?Arg?Ile?Val?Ala?Arg?Leu?Thr?Gly?Thr?Arg?Pro?Ser
225 230 235 240
Met?Asp?Leu?Lys?Val?Glu?Thr?Asp?Tyr?Cys?Tyr?His?Thr?Asp?Thr?Val
245 250 255
Thr?Gly?Pro?Gly?Trp?Leu?Met?Val?Gly?Asp?Ala?Gly?Cys?Phe?Gly?Asp
260 265 270
Pro?Met?Phe?Ser?Gly?Gly?Val?Leu?Val?Ala?Thr?Ala?Thr?Ala?Val?Arg
275 280 285
Ala?Ala?Glu?Thr?Leu?Gly?Glu?Val?Leu?Ala?Asp?Pro?Ser?Ala?Glu?Asp
290 295 300
Arg?Leu?Leu?Glu?Arg?Tyr?Ser?Asn?Tyr?Phe?Lys?Thr?Gly?Tyr?Asp?Thr
305 310 315 320
Tyr?Ile?Arg?Leu?Ile?His?Ser?Tyr?Tyr?Asp?Gly?Glu?Leu?Val?Ala?Met
325 330 335
Ala?Ala?Asp?Ala?Ala?Arg?Ser?Thr?Asp?Arg?Glu?Thr?Leu?Glu?Lys?Tyr
340 345 350
Leu?Met?Arg?Leu?Ile?Gly?Gly?Asp?Phe?Trp?Ser?Glu?His?Asn?Ser?Val
355 360 365
Ala?Gln?Glu?Met?Arg?Arg?Arg?Lys?Glu?Trp?Asp?Thr?Phe?Glu?Pro?Phe
370 375 380
Gln?Arg?Val?Tyr?Gly?Cys?Pro?Ser?Tyr?Pro?His?Leu?Asp?Glu?Leu?Asp
385 390 395 400
Arg?Lys?Glu?Arg?Ser?Glu?Ala?Arg?Val?Arg?Arg?Val?Thr?Ala?Gly?Arg
405 410 415
<210>9
<211>356
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>9
Met?Ala?Ser?Ile?Pro?Leu?Arg?Leu?Lys?Asp?His?Ser?Tyr?Asp?Val?Leu
1 5 10 15
Ile?Gly?Pro?Gly?Val?Arg?Thr?Ser?Leu?Ala?Glu?Val?Val?Gly?Arg?Leu
20 25 30
Gly?Ala?Gly?Arg?Ala?Val?Val?Val?Ser?Ala?Arg?Pro?Arg?Glu?Trp?Val
35 40 45
Pro?Asp?Thr?Gly?Val?Asp?Thr?Leu?Phe?Leu?Pro?Ala?Arg?Asp?Gly?Glu
50 55 60
Arg?Asp?Lys?Thr?Leu?Gly?Thr?Val?Glu?Gln?Leu?Cys?Gly?Glu?Phe?Val
65 70 75 80
Arg?Phe?Gly?Leu?Thr?Arg?Ser?Asp?Val?Val?Val?Ser?Cys?Gly?Gly?Gly
85 90 95
Thr?Thr?Thr?Asp?Val?Val?Gly?Leu?Ala?Ala?Ala?Leu?Tyr?His?Arg?Gly
100 105 110
Val?Ala?Val?Val?His?Leu?Pro?Thr?Thr?Leu?Leu?Ala?Gln?Val?Asp?Ala
115 120 125
Ser?Val?Gly?Gly?Lys?Thr?Ala?Val?Asn?Leu?Pro?Ala?Gly?Lys?Asn?Leu
130 135 140
Val?Gly?Ala?Tyr?Trp?Gln?Pro?Ser?Ala?Val?Leu?Cys?Asp?Thr?Asp?Tyr
145 150 155 160
Leu?Ser?Thr?Leu?Pro?Arg?Arg?Glu?Leu?Leu?Asn?Gly?Tyr?Gly?Glu?Ile
165 170 175
Ala?Arg?Cys?His?Phe?Ile?Gly?Ala?Pro?Asp?Leu?Arg?Ala?Leu?Pro?Pro
180 185 190
Ala?Glu?Gln?Ile?Ala?Ala?Ser?Val?Ala?Leu?Lys?Ala?Arg?Val?Val?Glu
195 200 205
Ala?Asp?Glu?Arg?Asp?Ala?Gly?Pro?Arg?His?Ile?Leu?Asn?Tyr?Gly?His
210 215 220
Thr?Leu?Gly?His?Ala?Leu?Glu?Leu?Ala?Thr?Gly?Phe?Ala?Leu?Arg?His
225 230 235 240
Gly?Glu?Ala?Val?Ala?Val?Gly?Thr?Val?Phe?Ala?Gly?Arg?Leu?Ala?Gly
245 250 255
Ala?Leu?Gly?Arg?Ile?Gly?Gly?Glu?Arg?Val?Ala?Glu?His?His?Asp?Val
260 265 270
Val?Arg?Ala?Tyr?Gly?Leu?Pro?Ala?Ala?Leu?Pro?Ala?Glu?Thr?Glu?Pro
275 280 285
Ala?Glu?Leu?Val?Arg?Leu?Met?Arg?His?Asp?Lys?Lys?Ala?Leu?Ser?Gly
290 295 300
Leu?Thr?Phe?Val?Leu?Asp?Gly?Pro?Lys?Gly?Val?Glu?Leu?Val?Tyr?Asp
305 310 315 320
Val?Pro?Pro?Glu?Leu?Val?Thr?Arg?Val?Leu?Asp?Arg?Met?Pro?Arg?Ala
325 330 335
Pro?Leu?Ala?Glu?Leu?Val?Gly?Asp?Ala?Glu?Pro?Ala?Ala?Thr?Pro?Ala
340 345 350
Thr?Ala?Arg?Ser
355
<210>10
<211>445
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>10
Met?Arg?Gln?Pro?Thr?Arg?Trp?Pro?Pro?Gly?Thr?Ala?Ala?Pro?Thr?Pro
1 5 10 15
Ala?Glu?Thr?Pro?Ala?Thr?Pro?Ile?Gly?Asp?Thr?Ala?Leu?Pro?Gly?Ala
20 25 30
Pro?Ala?Pro?Thr?His?Asp?Pro?Ala?Ala?Leu?Ile?Gly?Ser?Pro?Leu?Gly
35 40 45
Gly?Arg?Leu?Ala?Asp?Ala?Leu?Ala?Arg?Pro?Ala?Ala?Gln?Gln?Pro?His
50 55 60
Trp?Pro?Asp?Pro?Ala?Arg?Ala?Glu?Arg?Ile?Thr?Ala?Leu?Leu?Gly?Arg
65 70 75 80
Ala?Ala?Pro?Val?Val?Thr?Pro?Ala?Glu?Thr?Ala?Arg?Leu?Arg?Ala?Glu
85 90 95
Leu?Ala?Ala?Val?Ala?Arg?Gly?Glu?Ala?Phe?Leu?Leu?Gln?Ala?Gly?Asp
100 105 110
Cys?Ala?Glu?Ala?Phe?Ala?Glu?Asn?Thr?Gln?Ala?His?Gln?Arg?Ala?Asn
115 120 125
Leu?Ser?Thr?Leu?Ala?Glu?Met?Ala?Asp?Val?Leu?Thr?Arg?Arg?Thr?Gly
130 135 140
Leu?Pro?Val?Val?Lys?Ile?Ala?Arg?Met?Ala?Gly?Gln?Tyr?Ala?Lys?Pro
145 150 155 160
Arg?Ser?Arg?Ala?Val?Asp?Ala?Gln?Gly?Leu?Pro?Ala?Tyr?Arg?Gly?Asp
165 170 175
Met?Val?Asn?Ser?Ala?Glu?Pro?Thr?Thr?Ala?Ala?Arg?Thr?Pro?Asp?Pro
180 185 190
Gly?Arg?Met?Leu?Arg?Val?His?Ala?Glu?Ala?Ala?Arg?Thr?Met?Ala?Leu
195 200 205
Val?Arg?Arg?Thr?Gly?Arg?Gly?Asp?Val?Tyr?Val?Ser?His?Glu?Ala?Leu
210 215 220
Leu?Leu?Asp?Tyr?Glu?Arg?Ser?Ser?Leu?Arg?Ala?Asp?Thr?Asp?Gly?Pro
225 230 235 240
Glu?Pro?Arg?Leu?Thr?Ser?Gly?Leu?Gly?His?Phe?Leu?Trp?Ile?Gly?Glu
245 250 255
Arg?Thr?Arg?Glu?Pro?Asp?Gly?Ala?His?Ile?Ala?Phe?Ala?Glu?Leu?Leu
260 265 270
Ser?Asn?Pro?Leu?Gly?Leu?Lys?Ile?Gly?Pro?Gly?Thr?Thr?Pro?Glu?Gln
275 280 285
Ala?Ala?Ala?Tyr?Val?Arg?Arg?Leu?Asp?Pro?His?Ala?Glu?Pro?Gly?Arg
290 295 300
Leu?Thr?Leu?Ile?Ser?Arg?Met?Gly?His?Thr?Arg?Val?Arg?Asp?Val?Leu
305 310 315 320
Pro?Pro?Ile?Val?Glu?Lys?Val?Thr?Ala?Asp?Gly?His?Gln?Val?Ile?Trp
325 330 335
Gln?Cys?Asp?Pro?Met?His?Ala?Asn?Thr?Tyr?Thr?Thr?Ala?Gly?Gly?His
340 345 350
Lys?Thr?Arg?His?Trp?Asn?Ala?Ile?Ala?Asp?Glu?Ile?Thr?Gly?Phe?Phe
355 360 365
Asp?Val?His?Arg?Ala?Leu?Gly?Thr?His?Pro?Gly?Gly?Val?His?Leu?Glu
370 375 380
Val?Thr?Gly?Asp?Pro?Val?Thr?Glu?Cys?Val?Gly?Gly?Thr?Gly?Gly?Pro
385 390 395 400
Ala?Glu?Ser?Asp?Leu?Pro?Asp?Arg?Tyr?Arg?Thr?Ala?Cys?Asp?Pro?Arg
405 410 415
Leu?Asn?Ala?Asp?Gln?Ala?Arg?Glu?Leu?Ala?His?Val?Val?Ala?Arg?Leu
420 425 430
Ala?Ala?Gly?Ala?Ala?Ala?His?Arg?Glu?Glu?Gly?Pro?Arg
435 440 445
<210>11
<211>270
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>11
Met?Thr?Ala?Pro?Thr?Pro?Ala?Ala?Pro?Ile?Gly?Gly?Thr?Thr?Arg?Leu
1 5 10 15
Tyr?Ala?Val?Leu?Gly?Asp?Pro?Val?Ala?Gln?Val?Gln?Ala?Pro?Ala?Leu
20 25 30
Ile?Asn?Pro?Leu?Leu?Ala?Ala?Leu?His?Arg?Asp?Ala?Val?Val?Val?Pro
35 40 45
Val?His?Ala?Arg?Pro?Pro?His?Leu?Glu?Pro?Val?Val?Arg?Gly?Leu?Gln
50 55 60
Arg?Val?Glu?Asn?Leu?Asp?Gly?Leu?Phe?Val?Thr?Val?Pro?His?Lys?Val
65 70 75 80
Ala?Val?Arg?Arg?Leu?Ala?Asp?Arg?Cys?Gly?Pro?Thr?Val?Asp?Ile?Val
85 90 95
Gly?Ser?Ala?Asn?Val?Leu?Arg?Arg?Glu?Pro?Asp?Gly?Thr?Trp?Leu?Ala
100 105 110
Glu?Asn?Phe?Asp?Gly?Ser?Gly?Phe?Val?Ala?Gly?Leu?Val?Ala?Ala?Gly
115 120 125
His?Asp?Pro?Arg?Gly?Ser?Arg?Ala?Ala?Leu?Val?Gly?Thr?Gly?Gly?Ala
130 135 140
Gly?Ser?Ala?Ile?Ala?Ala?Ala?Leu?Leu?Ala?Ala?Gly?Val?Glu?His?Leu
145 150 155 160
Leu?Val?His?Asp?Thr?Asp?Thr?Ala?Lys?Leu?Gly?Ala?Leu?Ala?Ala?Arg
165 170 175
Leu?Asp?Ala?His?Trp?Pro?Gly?Arg?Val?His?Pro?Leu?Ala?Ala?Pro?Thr
180 185 190
Leu?Glu?Asp?Thr?Asp?Ile?Ala?Val?Asn?Ala?Thr?Pro?Leu?Gly?Leu?Arg
195 200 205
Ala?His?Asp?Pro?Leu?Pro?Phe?Pro?Leu?Glu?Pro?Leu?Pro?Pro?Gly?Cys
210 215 220
Val?Val?Ala?Asp?Ile?Ile?Met?Lys?Pro?Arg?Glu?Thr?Arg?Leu?Leu?Arg
225 230 235 240
Glu?Ala?Ala?Ala?Arg?Gly?His?Arg?Ile?His?His?Gly?Ile?His?Met?Leu
245 250 255
Glu?Gly?Gln?Leu?Asn?Ser?Tyr?Arg?Glu?Phe?Phe?Asp?Leu?Arg
260 265 270
<210>12
<211>417
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>12
Met?Gln?Arg?Pro?Arg?Arg?Lys?Pro?Asn?Leu?Glu?Thr?Ala?Val?Lys?Ala
1 5 10 15
Val?Pro?Cys?Leu?Gly?Ile?Glu?Pro?Leu?Pro?Val?Ser?Trp?Arg?Ile?Met
20 25 30
Asn?Val?Arg?Gln?Ala?Pro?Glu?Tyr?Pro?Gln?Trp?Pro?Gln?Tyr?Asp?Glu
35 40 45
Lys?Glu?Arg?Glu?Gly?Leu?Ile?Arg?Ala?Leu?Glu?Gln?Gly?Gln?Trp?Trp
50 55 60
Arg?Met?Gly?Gly?Ser?Glu?Val?Asp?Ser?Phe?Glu?Arg?Glu?Phe?Ala?Glu
65 70 75 80
Leu?His?Gly?Ala?Pro?His?Ala?Leu?Ala?Val?Thr?Asn?Gly?Thr?His?Ala
85 90 95
Leu?Glu?Leu?Ala?Leu?Gln?Val?Met?Gly?Val?Gly?Pro?Gly?Thr?Glu?Val
100 105 110
Val?Val?Pro?Ala?Phe?Thr?Phe?Ile?Ser?Ser?Ser?Gln?Ala?Ala?Gln?Arg
115 120 125
Leu?Gly?Ala?Val?Ala?Val?Pro?Val?Asp?Ile?Glu?Pro?Asp?Thr?Tyr?Asn
130 135 140
Ile?Asp?Val?Ala?Ala?Ala?Ala?Ala?Ala?Val?Thr?Ser?Arg?Thr?Arg?Ala
145 150 155 160
Ile?Met?Pro?Val?His?Met?Ala?Gly?Phe?Leu?Ala?Asp?Met?Asp?Ala?Leu
165 170 175
Ala?Lys?Leu?Ser?Ala?Asp?Thr?Gly?Val?Pro?Leu?Leu?Gln?Asp?Ala?Ala
180 185 190
His?Ala?Gln?Ala?Ala?Arg?Arg?Gln?Gly?Lys?Arg?Val?Gly?Glu?Leu?Gly
195 200 205
Thr?Ile?Ala?Ala?Phe?Ser?Phe?Gln?Asn?Gly?Lys?Leu?Met?Thr?Ala?Gly
210 215 220
Glu?Gly?Gly?Ala?Val?Leu?Phe?Pro?Asp?Thr?Glu?Ser?Tyr?Glu?Ala?Ala
225 230 235 240
Phe?Leu?Arg?His?Ser?Cys?Gly?Arg?Pro?Arg?Thr?Asp?Arg?Arg?Tyr?Leu
245 250 255
His?Gln?Val?Ala?Gly?Thr?Asn?Leu?Arg?Leu?Asn?Glu?Phe?Ser?Ala?Ala
260 265 270
Val?Leu?Arg?Ala?Gln?Leu?Ser?Arg?Leu?Glu?Gln?Gln?Ile?Ala?Thr?Arg
275 280 285
Arg?Gln?Arg?Trp?Ala?Val?Leu?Ser?Pro?Leu?Leu?Asp?Ala?Ile?Asp?Gly
290 295 300
Val?Val?Pro?Gln?Arg?Pro?Asp?Ala?His?Thr?Asp?Ser?Pro?Ser?His?Tyr
305 310 315 320
Met?Ala?Met?Phe?Arg?Val?Pro?Gly?Ile?Gly?Glu?Asp?Asp?Arg?Asn?Ala
325 330 335
Leu?Val?Asp?Arg?Leu?Val?Glu?Ala?Gly?Val?Pro?Ala?Phe?Ala?Ala?Phe
340 345 350
Arg?Ala?Ile?Tyr?Arg?Thr?Asp?Ala?Phe?Trp?Glu?Thr?Cys?Ala?Pro?Asp
355 360 365
Glu?Thr?Pro?Glu?Gln?Ile?Ala?Glu?Arg?Cys?Pro?His?Thr?Glu?Ala?Val
370 375 380
Ser?Arg?Asp?Cys?Val?Trp?Leu?His?His?Arg?Val?Leu?Leu?Ala?Gly?Glu
385 390 395 400
Gln?Asp?Met?His?Arg?Thr?Ala?Glu?Ile?Ile?Ala?Asp?Ala?Val?Ala?Ala
405 410 415
Val
<210>13
<211>362
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>13
Met?Ser?Ile?Arg?Thr?Ala?Val?Val?Gly?Leu?Gly?Trp?Ala?Gly?Arg?Glu
1 5 10 15
Leu?Trp?Leu?Pro?Arg?Leu?Thr?Glu?His?Thr?Gly?Phe?Asp?Val?Val?Ala
20 25 30
Val?Val?Asp?Pro?Ala?Pro?Arg?Ala?Arg?Thr?Val?Leu?Asp?Ala?Ala?Pro
35 40 45
Gly?Val?Pro?Val?His?Pro?Thr?Ala?Asp?Ala?Leu?Thr?Ala?Arg?Ala?Val
50 55 60
Asp?Leu?Ala?Val?Val?Ala?Val?Pro?Asn?His?Leu?His?Ala?Asp?Val?Ala
65 70 75 80
Ala?Gly?Leu?Leu?Arg?Arg?Gly?Val?Ser?Val?Phe?Leu?Glu?Lys?Pro?Val
85 90 95
Cys?Leu?Thr?Ser?Arg?Glu?Ala?Asp?Thr?Leu?Ala?Ala?Ala?Glu?Arg?Asp
100 105 110
Gly?Gly?Ala?Thr?Leu?Leu?Ala?Gly?Ser?Ala?Ala?Pro?His?Arg?Ala?Asp
115 120 125
Val?Gly?Ala?Leu?Ala?Asn?Leu?Leu?Pro?Gly?Leu?Gly?Arg?Ile?Arg?His
130 135 140
Val?Asp?Leu?Ser?Trp?Val?Arg?Ala?Arg?Gly?Ile?Pro?Gln?Ala?Gly?Gly
145 150 155 160
Trp?Phe?Thr?Gln?Arg?Ser?Lys?Ala?Gly?Gly?Gly?Val?Leu?Phe?Asp?Leu
165 170 175
Gly?Trp?His?Leu?Leu?Asp?Thr?Leu?Thr?Ser?Leu?Leu?Gly?Pro?Ala?Arg
180 185 190
Phe?Thr?Gln?Val?Leu?Gly?Val?Thr?Ser?Asn?Asp?Phe?Leu?Asp?Thr?Gly
195 200 205
Ala?Trp?Ser?Ala?Ala?Trp?Arg?Gln?Asp?Ala?Val?Pro?Ala?Pro?Ala?Ala
210 215 220
Gly?Gly?Val?Asp?Val?Glu?Asp?Thr?Ala?Arg?Gly?Phe?Leu?Val?Arg?Asp
225 230 235 240
Asp?Gly?Val?Ser?Val?Gly?Leu?Arg?Ala?Gly?Trp?Ala?Ser?His?Gln?Ala
245 250 255
Arg?Asp?Val?Thr?Arg?Ile?Arg?Val?Thr?Gly?Ser?Ala?Ala?Thr?Ala?Glu
260 265 270
Leu?Arg?Cys?Thr?Phe?Gly?Phe?Ser?Pro?Asn?Arg?His?Pro?His?Ala?Gly
275 280 285
Leu?Thr?Leu?Thr?Arg?Glu?Gly?Thr?Thr?Thr?Ser?Leu?Pro?Val?Pro?Gln
290 295 300
Glu?Pro?Ile?Gly?Thr?Glu?Tyr?Arg?Arg?Gln?Leu?Asp?Val?Leu?Pro?Gly
305 310 315 320
Val?Leu?Ser?Asp?Pro?Gly?His?Arg?Gly?Arg?Thr?Ala?Glu?Glu?Ala?Arg
325 330 335
Thr?Thr?Val?Arg?Val?Ile?Glu?Asp?Phe?Tyr?Ala?Ala?Ala?Arg?Arg?Ala
340 345 350
His?Glu?Gln?Thr?Ala?Val?Pro?Ala?His?His
355 360
<210>14
<211>244
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>14
Val?Thr?Ser?Pro?Leu?Ser?Thr?Gly?Pro?Ala?Trp?Leu?Ala?Gln?Arg?Pro
1 5 10 15
Thr?Ala?Pro?Gly?Ala?Gly?Arg?Pro?Ala?Thr?Gly?Thr?Leu?Arg?Pro?Val
20 25 30
Arg?Arg?Ala?Val?Val?Phe?Asp?Leu?Asp?Gly?Val?Leu?Val?Asp?Ser?Phe
35 40 45
Ala?Val?Met?Tyr?Glu?Ala?Phe?Ala?Val?Ala?Tyr?Lys?Glu?Val?Val?Gly
50 55 60
Asp?Gly?Pro?Ala?Pro?Phe?Asp?Glu?Tyr?Arg?Arg?His?Leu?Gly?Arg?Phe
65 70 75 80
Phe?Pro?Asp?Ile?Met?Arg?Ile?Met?Gly?Leu?Pro?Leu?Glu?Met?Glu?Glu
85 90 95
Pro?Phe?Val?Arg?Glu?Ser?Tyr?Arg?Leu?Ala?Ser?Gln?Val?Pro?Val?Phe
100 105 110
Asp?Gly?Val?Val?Glu?Leu?Leu?Thr?Thr?Leu?Arg?Val?Arg?Gly?Tyr?Arg
115 120 125
Leu?Ala?Val?Ala?Thr?Gly?Lys?Ser?Gly?Glu?Arg?Ala?Arg?Ser?Leu?Leu
130 135 140
Gly?Gly?Leu?Gly?Leu?Leu?Pro?Phe?Phe?Asp?His?Val?Ile?Gly?Ser?Asp
145 150 155 160
Glu?Val?Ala?Arg?Pro?Lys?Pro?Ala?Pro?Asp?Ile?Val?Glu?His?Ala?Leu
165 170 175
Asp?Leu?Met?Gly?Phe?Thr?Pro?Glu?Gln?Ala?Val?Met?Val?Gly?Asp?Ala
180 185 190
Pro?Thr?Asp?Ile?Ala?Ser?Ala?His?Gly?Ala?Gly?Val?Thr?Ser?Ala?Gly
195 200 205
Ala?Leu?Trp?Ala?Leu?Ser?Asp?Ala?Glu?Glu?Leu?Leu?Ala?Ala?Gly?Pro
210 215 220
Asp?Ile?Val?Leu?Ala?Arg?Pro?Gly?Asp?Leu?Leu?Ala?Leu?Cys?Pro?Ser
225 230 235 240
Val?Pro?Gly?Asp
<210>15
<211>300
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>15
Val?Thr?Glu?Asp?Gly?Pro?Cys?Leu?Gly?Val?Asp?Ile?Gly?Gly?Thr?Lys
1 5 10 15
Val?Ala?Leu?Arg?Val?Glu?Ala?Gly?Ala?Arg?Cys?Val?Ala?Glu?Thr?Val
20 25 30
Phe?Ala?Trp?Gln?Pro?Arg?His?Ser?Ala?Asp?Arg?Asp?Leu?Ala?Gln?Leu
35 40 45
Ala?Ala?His?Val?Gly?Gly?Leu?Ser?Glu?Arg?Leu?Ala?Val?Pro?Pro?Arg
50 55 60
Ala?Val?Gly?Val?Ala?Val?Pro?Ala?Thr?Val?Gly?Pro?Asp?Glu?Arg?Val
65 70 75 80
Thr?Ala?Trp?Pro?Ser?Arg?Pro?Glu?Trp?Thr?Gly?Thr?Asp?Leu?Gly?Ala
85 90 95
Ala?Leu?Arg?Ala?Leu?Leu?Pro?Gly?Thr?Pro?Val?Ala?Trp?Ala?Asp?Asp
100 105 110
Gly?Asp?Leu?Gly?Ala?Leu?Ala?Glu?Ala?Arg?Ala?Ala?Asp?Cys?Ala?Asp
115 120 125
Leu?Leu?Tyr?Ile?Gly?Val?Gly?Thr?Gly?Val?Gly?Gly?Gly?Leu?Val?Leu
130 135 140
Arg?Gly?Asp?Leu?Cys?Pro?Gly?Leu?Gly?Arg?Gly?Ser?Phe?Glu?Ile?Gly
145 150 155 160
His?Thr?Val?Val?Asp?Leu?Asp?Gly?Pro?Arg?Cys?Val?Cys?Gly?Arg?Arg
165 170 175
Gly?Cys?Leu?Gln?Ala?Ile?Ala?Ser?Gly?Pro?Ala?Thr?Leu?Arg?His?Ala
180 185 190
Ala?Arg?Leu?Arg?Gly?Ser?Asp?Val?Asp?Tyr?Asp?Ala?Leu?Arg?Arg?Ala
195 200 205
Trp?Leu?Asp?Ala?Ala?Pro?Trp?Ala?Val?Thr?Ala?Leu?Arg?Arg?Thr?Cys
210 215 220
Arg?Ala?Leu?Ala?Ala?Ala?Ala?Thr?Gly?Val?Gln?Glu?Leu?Leu?Arg?Pro
225 230 235 240
Arg?Leu?Leu?Leu?Ile?Gly?Gly?Gly?Phe?Ala?Ser?Gly?Leu?Pro?Gly?Leu
245 250 255
Asp?Ala?Leu?Leu?Thr?Glu?His?Leu?Ala?Gly?Leu?Ala?Arg?Pro?Gly?His
260 265 270
Pro?Pro?Leu?Thr?Ala?Arg?Pro?Ala?Ala?Leu?Gly?Gly?Leu?Ser?Ser?Leu
275 280 285
Arg?Gly?Ala?Val?Glu?Leu?Ala?Arg?Leu?Thr?His?Ala
290 295 300
<210>16
<211>553
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>16
Met?Ser?Thr?Thr?Arg?Pro?His?Asp?Pro?Tyr?Glu?Ser?Pro?Thr?Asp?Thr
1 5 10 15
Gly?Thr?Asp?Thr?Asp?Val?Ala?Val?Val?Gly?Asn?Gly?Pro?Val?Gly?Ala
20 25 30
Ala?Leu?Ser?Val?Leu?Leu?Ala?Gln?Arg?Gly?Leu?Arg?Val?Thr?Val?Leu
35 40 45
Glu?Arg?Arg?Pro?Arg?Pro?Tyr?Leu?Leu?Pro?Arg?Ala?Thr?Ser?Phe?Asp
50 55 60
Gly?Glu?Thr?Ala?Arg?Leu?Leu?Ala?Ala?Thr?Gly?Val?Gly?Asp?Arg?Phe
65 70 75 80
Gly?Glu?Ile?Thr?Glu?Pro?Ala?Thr?Gly?Tyr?Gln?Trp?His?Thr?Ala?Ala
85 90 95
Gly?Glu?Thr?Leu?Leu?Asp?Ile?Ala?Phe?Ser?Pro?Thr?Gly?Arg?Tyr?Gly
100 105 110
Trp?Pro?Asp?Ala?Asn?Thr?Met?His?Gln?Pro?Ala?Leu?Glu?Arg?Leu?Leu
115 120 125
Ala?Asp?Arg?Ala?Ala?Ala?Leu?Pro?Gly?Val?Thr?Val?Leu?Arg?Gly?Arg
130 135 140
Arg?Val?Val?Asp?Leu?Ala?Glu?Arg?Asp?Asp?Arg?Val?Ser?Leu?Thr?Val
145 150 155 160
Glu?Thr?Asp?Asp?Gly?Ala?Ala?Arg?Thr?Val?Val?Ala?His?Trp?Val?Val
165 170 175
Gly?Cys?Asp?Gly?Ala?Asn?Ser?Phe?Val?Arg?Glu?His?Leu?Gly?Val?Pro
180 185 190
Met?Thr?Asp?Leu?Gly?Phe?Ser?Tyr?Glu?Trp?Leu?Leu?Cys?Asp?Val?Glu
195 200 205
Leu?Arg?Glu?Pro?Arg?Glu?Phe?Thr?Pro?Thr?Asn?Val?Gln?Ile?Cys?Asp
210 215 220
Pro?Ala?Arg?Pro?Thr?Thr?Leu?Val?Gly?Ser?Gly?Pro?Gly?His?Arg?Arg
225 230 235 240
Trp?Glu?Phe?Met?Arg?Leu?Pro?Gly?Glu?Ser?Ser?Ala?Glu?Leu?Asn?Arg
245 250 255
Pro?Glu?Thr?Ala?Trp?Arg?Leu?Leu?Lys?Pro?Phe?Gly?Val?Thr?Pro?Glu
260 265 270
Thr?Ala?Thr?Leu?Leu?Arg?Ser?Thr?Thr?Tyr?Ile?Phe?Arg?Ala?Ala?Trp
275 280 285
Ala?Asp?Glu?Trp?Arg?Ser?Gly?Arg?Val?Leu?Leu?Ala?Gly?Asp?Ala?Ala
290 295 300
His?Leu?Met?Pro?Pro?Phe?Ala?Gly?Gln?Gly?Met?Cys?Ser?Gly?Ile?Arg
305 310 315 320
Asp?Ala?Ala?Asn?Leu?Ala?Trp?Lys?Leu?Asp?Leu?Thr?Leu?Arg?Gly?Leu
325 330 335
Ala?Asp?Ala?Ser?Leu?Leu?Asp?Thr?Tyr?Ala?Glu?Glu?Arg?Arg?Gln?His
340 345 350
Val?Lys?Glu?Ser?Ile?Leu?Ser?Ser?Val?Gln?Leu?Gly?Arg?Val?Ile?Cys
355 360 365
Val?Thr?Asp?Pro?Ala?Ala?Ala?Ala?Glu?Arg?Asp?Ala?Thr?Val?Leu?Ala
370 375 380
Gly?Arg?Arg?Gly?Arg?Thr?Gly?Pro?Gly?Ala?Pro?Asp?Ala?Ala?Lys?Pro
385 390 395 400
Leu?Ser?Ala?Gly?Leu?Leu?Arg?Ala?Pro?Ala?Gly?Ala?Pro?Arg?Ala?Pro
405 410 415
Ala?Gly?Glu?Val?Val?Pro?Gln?Trp?Arg?Val?Ser?Thr?Ala?Gly?Gly?Thr
420 425 430
Gly?Leu?Phe?Asp?Ala?Val?Val?Gly?Gly?Gly?Phe?Val?Leu?Leu?Thr?Thr
435 440 445
Asp?Asp?Pro?Arg?Pro?Ala?Leu?Gly?Glu?Asp?Arg?Trp?Ser?Phe?Leu?Ala
450 455 460
Ala?Leu?Asp?Thr?Arg?Val?Val?Arg?Leu?Ser?Pro?Pro?Gly?Thr?Val?Leu
465 470 475 480
Pro?Pro?Glu?Asp?Thr?Glu?Pro?Gly?Leu?Thr?Asp?Val?Ile?Asp?Thr?Asp
485 490 495
Gly?Phe?Tyr?Arg?Ala?Tyr?Leu?Ser?Glu?His?Asp?Ala?Ser?Ala?Leu?Met
500 505 510
Val?Arg?Pro?Asp?His?His?Val?Phe?Gly?Ala?Ala?Arg?Gly?Ala?Glu?Asp
515 520 525
Thr?Ala?Ala?Leu?Val?Asp?Cys?Leu?Arg?Asp?Arg?Leu?Ala?Thr?Ala?Val
530 535 540
Pro?Ala?Gly?Gly?Pro?His?Arg?Arg?Thr
545 550
<210>17
<211>64
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>17
Val?Lys?Ile?Phe?Ala?Asp?Thr?Asp?Lys?Cys?Val?Gly?Ala?Gly?Gln?Cys
1 5 10 15
Val?Arg?Val?Ala?Pro?Glu?Leu?Phe?Asp?Gln?Gly?Glu?Asp?Asp?Gly?Val
20 25 30
Val?Val?Val?Leu?Asp?Pro?Glu?Pro?Gly?Gln?Ala?Leu?Trp?Pro?Ala?Ala
35 40 45
Asp?Glu?Ala?Val?Asp?Leu?Cys?Pro?Ala?Arg?Ala?Leu?Thr?Ala?Gly?Gly
50 55 60
<210>18
<211>261
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>18
Val?Pro?Arg?Thr?Pro?Glu?Gln?Phe?Gly?Thr?Trp?Val?Arg?Arg?Phe?Arg
1 5 10 15
Pro?Val?Thr?Asp?Ala?Asp?Val?Arg?Leu?Val?Cys?Leu?Pro?His?Ala?Gly
20 25 30
Gly?Ser?Ala?Ser?Phe?Tyr?Phe?Pro?Leu?Ser?Thr?Ser?Leu?Thr?Pro?Ala
35 40 45
Val?Asp?Val?Leu?Ala?Val?Gln?Tyr?Pro?Gly?Arg?Gln?Asp?Arg?Arg?His
50 55 60
Glu?Pro?Asn?Ile?Asp?Ser?Leu?Pro?Glu?Leu?Ala?Asp?Lys?Val?Phe?Glu
65 70 75 80
Ala?Ile?Arg?His?Leu?Asp?Asp?Arg?Pro?Leu?Ala?Leu?Phe?Gly?His?Ser
85 90 95
Met?Gly?Ala?Val?Leu?Ala?Tyr?Glu?Val?Ala?Leu?Arg?Leu?His?Asp?Ala
100 105 110
Gly?Leu?Pro?Ala?Pro?Val?Arg?Leu?Phe?Val?Ser?Gly?Arg?Arg?Ala?Pro
115 120 125
Ser?Arg?Asp?Arg?Asp?Glu?Arg?Leu?His?Leu?Ser?Ser?Asp?Glu?His?Leu
130 135 140
Leu?Ala?Glu?Val?Arg?Lys?Leu?Gly?Gly?Pro?His?Ala?Ala?Leu?Leu?Ala
145 150 155 160
Glu?Pro?Asp?Val?Arg?Asp?Met?Ile?Met?Pro?Ala?Leu?Arg?Gly?Asp?Tyr
165 170 175
Arg?Ala?Val?Glu?Ser?Tyr?Arg?Cys?Ala?Pro?Gly?Arg?Arg?Leu?Glu?Cys
180 185 190
Pro?Val?Thr?Val?Leu?Thr?Gly?Asp?Ser?Asp?Pro?Arg?Val?Ser?Val?Asp
195 200 205
Glu?Ala?Thr?Ala?Trp?Glu?Glu?His?Thr?Asn?Gly?Pro?Thr?Glu?Leu?Glu
210 215 220
Val?Phe?Pro?Gly?Gly?His?Phe?Phe?Leu?Leu?Asp?Gln?Asn?Ala?Arg?Leu
225 230 235 240
Thr?Arg?Leu?Leu?Ala?Asp?Arg?Leu?Arg?Arg?Arg?Pro?Val?Gly?Ala?Pro
245 250 255
His?Glu?Ala?Arg?Val
260
<210>19
<211>445
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>19
Val?Thr?Glu?Leu?Asn?Thr?Pro?Val?Pro?Thr?Ile?Pro?His?His?Ser?Leu
1 5 10 15
Leu?Val?Phe?Leu?Leu?Gln?Leu?Ala?Val?Leu?Leu?Leu?Leu?Ala?Leu?Ser
20 25 30
Leu?Gly?Gln?Leu?Ala?Ala?Arg?Phe?Lys?Met?Pro?Ala?Ile?Val?Gly?Glu
35 40 45
Leu?Leu?Ala?Gly?Val?Leu?Val?Gly?Pro?Ser?Val?Leu?Ser?His?Ala?Trp
50 55 60
Pro?Ala?Leu?Ala?Asp?Trp?Leu?Met?Pro?Lys?Asp?Thr?Ala?Gln?Met?His
65 70 75 80
Met?Leu?Asp?Ala?Val?Gly?Gln?Val?Gly?Val?Val?Leu?Leu?Val?Gly?Ile
85 90 95
Thr?Gly?Met?Glu?Leu?Lys?Phe?Asp?Leu?Val?Arg?Arg?Arg?Arg?Leu?Thr
100 105 110
Ala?Ala?Arg?Val?Ser?Val?Cys?Gly?Leu?Val?Leu?Pro?Leu?Ala?Leu?Gly
115 120 125
Val?Gly?Val?Gly?Phe?Leu?Leu?Pro?Ser?Ser?Ile?Arg?Pro?Asp?Gly?Thr
130 135 140
Ser?Pro?Thr?Val?Phe?Ala?Ile?Phe?Leu?Gly?Val?Ala?Leu?Cys?Val?Thr
145 150 155 160
Ala?Ile?Pro?Val?Ile?Ala?Lys?Thr?Leu?Met?Asp?Met?Asn?Leu?Leu?His
165 170 175
Arg?Asp?Ile?Gly?Gln?Leu?Thr?Leu?Ala?Ala?Gly?Val?Leu?Asp?Asp?Val
180 185 190
Val?Gly?Trp?Phe?Leu?Leu?Ser?Ile?Val?Ser?Ala?Met?Ala?Thr?Ala?Gly
195 200 205
Leu?Ser?Thr?Gly?Thr?Val?Ala?Thr?Ser?Leu?Leu?Tyr?Pro?Val?Gly?Val
210 215 220
Val?Leu?Ala?Ala?Trp?Val?Val?Gly?Arg?Pro?Leu?Val?Lys?Ala?Ala?Leu
225 230 235 240
Arg?Ala?Ala?Gly?Arg?Ser?Ala?Ser?Pro?Val?Pro?Thr?Val?Ala?Val?Thr
245 250 255
Ala?Leu?Thr?Val?Leu?Leu?Gly?Ala?Ala?Ala?Thr?Gln?Ala?Leu?His?Leu
260 265 270
Glu?Ala?Val?Phe?Gly?Ala?Phe?Val?Cys?Gly?Ala?Leu?Ile?Gly?Thr?Ser
275 280 285
Gly?Gln?Leu?Asp?Arg?Glu?Lys?Leu?Ala?Pro?Leu?Arg?Thr?Thr?Val?Leu
290 295 300
Ala?Phe?Leu?Ala?Pro?Val?Phe?Phe?Ala?Thr?Ala?Gly?Ile?Arg?Met?Asp
305 310 315 320
Leu?Thr?Ala?Leu?Thr?Asp?Pro?Thr?Val?Leu?Ala?Ala?Ala?Cys?Ala?Val
325 330 335
Leu?Ala?Val?Ala?Ile?Ile?Gly?Lys?Phe?Ala?Gly?Ala?Phe?Ala?Gly?Ala
340 345 350
Lys?Met?Ser?Gly?Leu?Gly?Arg?Trp?Glu?Gly?Leu?Ala?Leu?Gly?Ala?Gly
355 360 365
Met?Asn?Ser?Arg?Gly?Val?Ile?Glu?Val?Val?Val?Ala?Met?Val?Gly?Leu
370 375 380
Gln?Leu?Gly?Val?Leu?Ser?Ala?Glu?Ala?Tyr?Thr?Ile?Val?Ile?Leu?Val
385 390 395 400
Ala?Ile?Val?Thr?Ser?Leu?Met?Ala?Pro?Pro?Val?Leu?Arg?Val?Ala?Met
405 410 415
Ala?Arg?Ile?Asp?Glu?Asp?Ala?Glu?Ala?Gly?Met?Gly?Met?Ala?Gly?Thr
420 425 430
Ala?Pro?Arg?Asp?Leu?Ala?Ala?Pro?Pro?Ser?Ala?Ser?Val
435 440 445
<210>20
<211>280
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>20
Val?Thr?Thr?Ala?Gly?Thr?Tyr?Arg?Gly?Gly?Arg?Leu?Leu?Ala?Ile?Ser
1 5 10 15
Asp?Leu?His?Val?Gly?His?Ala?Asp?Asn?Arg?Ala?Leu?Val?Glu?Arg?Met
20 25 30
Ala?Pro?Gly?Thr?Asp?Glu?Asp?Trp?Leu?Leu?Val?Ala?Gly?Asp?Val?Ala
35 40 45
Glu?Thr?Val?Thr?Asp?Ile?His?Trp?Cys?Leu?Lys?Thr?Leu?Ala?Gly?Arg
50 55 60
Phe?Arg?Lys?Val?Val?Trp?Val?Pro?Gly?Asn?His?Glu?Leu?Trp?Thr?His
65 70 75 80
Pro?Ser?Asp?Thr?Val?Thr?Leu?Arg?Gly?Val?Ala?Arg?Tyr?Glu?His?Leu
85 90 95
Val?Glu?Leu?Cys?Arg?Asp?Leu?Gly?Val?Thr?Thr?Pro?Glu?Asp?Pro?Tyr
100 105 110
Pro?Leu?Trp?His?Gly?Pro?Asp?Gly?Pro?Val?Val?Val?Ala?Pro?Leu?Phe
115 120 125
Leu?Leu?Tyr?Asp?Tyr?Ser?Phe?Leu?Pro?Ala?Gly?Cys?Ala?Thr?Lys?Asp
130 135 140
Glu?Gly?Leu?Ala?Tyr?Ala?His?Glu?Thr?Gly?Val?Val?Cys?Asn?Asp?Glu
145 150 155 160
Ser?Leu?Leu?His?Pro?Asp?Pro?Tyr?Pro?Ser?Arg?Glu?Ala?Trp?Cys?Arg
165 170 175
Ala?Arg?Val?Ala?Glu?Thr?Gly?Arg?Arg?Leu?Ala?Ala?Leu?Pro?Asp?Gly
180 185 190
Thr?Pro?Val?Val?Leu?Val?Asn?His?Tyr?Pro?Leu?His?Arg?His?Pro?Thr
195 200 205
Glu?Val?Leu?Trp?Tyr?Pro?Glu?Phe?Ala?Met?Trp?Cys?Gly?Thr?Arg?Leu
210 215 220
Thr?Ala?Asp?Trp?His?Arg?Arg?Tyr?Pro?Thr?Ala?Ala?Val?Val?Tyr?Gly
225 230 235 240
His?Leu?His?Ile?Pro?Arg?Thr?Ala?His?His?Glu?Gly?Val?Arg?Phe?Glu
245 250 255
Glu?Val?Ser?Val?Gly?Tyr?Pro?Arg?Glu?Trp?Arg?Arg?Arg?Gln?Thr?Pro
260 265 270
Pro?Gly?Thr?Pro?Arg?Thr?Ile?Leu
275 280
<210>21
<211>439
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>21
Val?Met?Leu?Asp?Ser?Pro?Phe?Arg?Leu?Arg?Leu?Pro?Pro?Val?Phe?Ser
1 5 10 15
Val?Leu?Arg?Val?Cys?Arg?Asn?Asn?Ala?Cys?Glu?Ser?Ser?Ala?Leu?Ser
20 25 30
Glu?Ser?Ser?Phe?Ser?Ala?Trp?Ser?Arg?Gly?Asp?Leu?Glu?Glu?Gly?Ile
35 40 45
Arg?Leu?Ala?Glu?Ala?Ala?Val?Arg?Thr?Glu?Pro?Asp?Cys?Ala?Gly?Asn
50 55 60
Cys?Glu?Ala?Pro?Ala?Arg?Ala?Trp?His?Ala?Ala?Leu?Leu?Val?Arg?Val
65 70 75 80
Arg?Arg?Leu?Ser?Ser?Ala?Ala?Leu?Val?Leu?Ala?Glu?Val?Asp?Glu?Leu
85 90 95
Ser?Ala?Arg?Ser?Asp?Ala?Asp?Gly?Gly?Thr?Ala?Val?Ala?Ser?Leu?Leu
100 105 110
Gly?Ala?Ala?Asp?Leu?Ala?Phe?Ala?Arg?Gly?Asp?Thr?Ser?Ala?Ala?Val
115 120 125
Asp?Leu?Ala?Ala?Arg?Gly?Ala?Asp?Arg?Ala?Arg?Arg?Ala?Gly?Leu?His
130 135 140
Gly?Phe?Leu?Pro?Asp?Ala?His?Thr?Val?Leu?Ala?Leu?Gly?Ala?Leu?Arg
145 150 155 160
Gln?Gly?Asp?Met?Ser?Val?Ser?Ala?Gln?Phe?Ala?Asp?Glu?Leu?Arg?Asp
165 170 175
Cys?Ala?Leu?Leu?Gly?Arg?Thr?Ala?His?Gly?Pro?Ser?Gln?Cys?Ala?Trp
180 185 190
Ala?Ala?Ala?Gln?Leu?Leu?Glu?Val?Gln?Gly?Gly?Pro?Ala?Ser?Ala?Ala
195 200 205
Gln?Leu?Ile?Ala?Gly?Ile?Val?Thr?Asp?Asp?Arg?Leu?Leu?Leu?Glu?Leu
210 215 220
Leu?Thr?Ser?Gln?Pro?Thr?Ala?Ala?Ala?Trp?Leu?Val?Arg?Ala?Thr?Arg
225 230 235 240
Lys?Leu?Gly?Asp?Glu?Val?Leu?Ala?Arg?Arg?Val?Val?Ala?Gly?Ala?Gly
245 250 255
Ala?Leu?Ala?Val?Arg?Asn?Pro?Gly?Leu?Cys?Ser?Val?Gly?Ala?Ala?Ala
260 265 270
Gly?His?Ala?Ala?Gly?Leu?Leu?Asp?Gly?Asp?Pro?Asp?Gly?Leu?Leu?Ala
275 280 285
Ala?Ala?Ala?Ala?His?Gln?Asp?Pro?Trp?Ala?Ala?Ala?Ser?Ala?Ala?Glu
290 295 300
Asp?Ala?Gly?Thr?Phe?Leu?Ala?Ala?Arg?Pro?Ala?Glu?Arg?Gln?Arg?Ala
305 310 315 320
Val?Thr?Ala?Phe?Glu?Ser?Ala?Ala?Asp?Gly?Tyr?Ala?Gly?Ala?Gly?Ala
325 330 335
Pro?Arg?Asp?Ala?Arg?Arg?Val?Ala?Ser?Arg?Leu?Arg?Ala?Leu?Gly?Val
340 345 350
Arg?Arg?Gly?Arg?His?Pro?Gln?Tyr?Ala?Gly?Arg?Ser?Gly?Pro?Asp?Ala
355 360 365
Gly?Ser?Leu?Thr?Asn?Thr?Glu?Ala?Ala?Val?Ala?Glu?Leu?Val?Ser?Gln
370 375 380
Gly?Phe?Thr?Asn?Ser?Gln?Val?Gly?Glu?Arg?Leu?Phe?Ile?Ser?Gly?His
385 390 395 400
Thr?Val?Ala?Phe?His?Leu?Lys?Lys?Ile?Phe?Arg?Lys?Met?Asn?Val?Ala
405 410 415
Ser?Arg?Val?Glu?Leu?Thr?Arg?Ala?Trp?Ser?Arg?Val?Pro?Gly?Ala?Tyr
420 425 430
Pro?Glu?Gly?Ala?Arg?Ala?Ser
435
<210>22
<211>144
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>22
Val?Leu?Leu?Leu?Asn?Gly?Pro?Asn?Leu?Gly?Ile?Leu?Gly?Arg?Arg?Glu
1 5 10 15
Pro?Glu?Ile?Tyr?Gly?Thr?Asp?Thr?Leu?Ala?Asp?Ile?Glu?Ala?Ala?Val
20 25 30
Ala?Asp?Glu?Leu?Ser?Asp?Arg?Gly?Trp?Lys?Val?Leu?Ser?Val?Gln?His
35 40 45
Asp?Ser?Glu?Gly?Asp?Leu?Val?Gly?Ala?Val?His?Arg?His?Ser?Asp?Ser
50 55 60
Thr?Val?Gly?Ala?Ile?Val?Asn?Pro?Gly?Ala?Leu?Met?Ile?Ala?Gly?Trp
65 70 75 80
Ser?Leu?Arg?Asp?Ala?Leu?Ala?Ser?Tyr?Ala?Pro?Pro?Trp?Ile?Glu?Val
85 90 95
His?Leu?Ser?Asn?Val?Trp?Ala?Arg?Glu?Gln?Phe?Arg?His?Glu?Ser?Val
100 105 110
Ile?Ala?Pro?Leu?Ala?Ser?Gly?Val?Val?Val?Gly?Leu?Gly?Ala?Tyr?Gly
115 120 125
Tyr?Arg?Leu?Ala?Ala?Arg?Ala?Leu?Thr?His?Leu?Ala?Pro?Ala?Pro?Leu
130 135 140
<210>23
<211>114
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>23
Val?Ser?Thr?Arg?Thr?Gly?Ser?Ala?Asp?Ser?Arg?Pro?Asp?His?Asp?Arg
1 5 10 15
Ser?Gln?Arg?Gln?Pro?Leu?Tyr?Arg?Cys?Ser?Pro?Arg?Pro?Gln?Thr?Glu
20 25 30
Asp?His?Met?Gly?Arg?Phe?Val?Ser?Glu?Val?Cys?Ala?Leu?Gly?Pro?Ala
35 40 45
Leu?Arg?Ala?Glu?Gln?Thr?Arg?Leu?His?Ala?Ala?Tyr?Arg?Glu?Trp?Cys
50 55 60
Arg?Ala?Glu?Gly?Val?His?Pro?Val?Ser?Ser?Arg?Ala?Leu?Ala?Ala?Arg
65 70 75 80
Ile?Arg?Glu?Thr?Val?Gly?Leu?Ala?Ser?Pro?Lys?Ala?Met?Val?Leu?Ser
85 90 95
Arg?Gln?Arg?Thr?Tyr?Tyr?Pro?Gly?Ile?Gly?Leu?Pro?Ala?Ala?Gly?Glu
100 105 110
Ala?Ala
<210>24
<211>305
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>24
Val?Ala?Asn?Leu?Val?Tyr?Lys?Arg?Val?Ser?Thr?Asp?Gln?Gln?Ser?Thr
1 5 10 15
Ala?Arg?Gln?Asp?Leu?Val?Leu?Ala?Glu?Ala?Gly?Ile?Glu?Asp?Pro?Val
20 25 30
Val?Phe?Glu?Glu?Asp?Pro?Gly?Thr?Ser?Ser?Arg?Leu?His?Pro?Leu?Gln
35 40 45
Arg?Pro?Lys?Phe?Gly?Glu?Leu?Leu?Thr?Tyr?Ala?Arg?Pro?Gly?Asp?Thr
50 55 60
Val?His?Ile?Ser?Glu?Met?Phe?Arg?Leu?Val?Arg?Gly?Asn?Gln?His?Ile
65 70 75 80
Leu?Asp?Val?Leu?Asp?Val?Leu?His?Arg?Asp?Arg?Leu?Ala?Leu?Arg?Ile
85 90 95
His?Asp?Gly?Ala?Phe?Ser?Ala?Met?Asp?Leu?Thr?Ala?Arg?His?Pro?Arg
100 105 110
Thr?Gly?Glu?Leu?Leu?Ser?Thr?Val?Lys?Phe?Met?Val?Gln?Thr?Leu?Ala
115 120 125
Ala?Ala?Gly?Glu?Leu?Gln?Arg?Asp?Leu?Gln?Arg?Glu?Leu?Thr?Tyr?Asp
130 135 140
Gly?Leu?Arg?Ala?Ala?Glu?Ala?Lys?Gly?Asn?Lys?Gly?Gly?Arg?Arg?Pro
145 150 155 160
Ala?Val?Ala?Ala?Ala?Thr?Ala?Ala?Asp?Val?Arg?Thr?Ala?Tyr?Leu?Gln
165 170 175
Gly?Arg?Ser?Ile?Ala?Ala?Leu?Ala?Arg?Asp?His?Asp?Val?Ser?Arg?Gly
180 185 190
Ala?Ile?Arg?Thr?Ala?Val?Ala?Asp?Leu?Leu?Leu?Glu?His?Thr?Ala?Thr
195 200 205
Lys?Glu?Asp?Ala?Pro?Ala?Pro?Glu?Leu?Pro?Val?Thr?Leu?Asp?Met?Pro
210 215 220
Gly?Lys?Val?Ala?Asp?Tyr?Leu?Arg?Thr?Thr?Glu?Leu?Glu?Pro?Ala?Glu
225 230 235 240
Arg?Ala?Val?Leu?Asp?Gln?Gly?Val?Thr?Val?Arg?Arg?Gly?Gln?Gly?Tyr
245 250 255
Thr?Leu?Arg?Val?Asn?Ala?Ala?Pro?Ala?Ile?His?Arg?Gln?Leu?Leu?Ala
260 265 270
Arg?Cys?Gln?Pro?Leu?Asp?Gly?Gly?Gln?Gly?Val?Pro?Ala?Val?Pro?Ala
275 280 285
Gln?Arg?Lys?Ala?Arg?Arg?Glu?Tyr?Glu?Asn?Arg?Val?Ser?Arg?Leu?Ala
290 295 300
Pro
305
<210>25
<211>345
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>25
Val?Asp?Thr?Ala?Gln?Pro?Asp?Arg?His?Gly?Pro?His?Thr?Arg?Ser?Arg
1 5 10 15
Ala?Asp?Ala?Ser?Gly?Val?Pro?Gly?Glu?Ala?Thr?Ala?Thr?Tyr?Tyr?Arg
20 25 30
Gln?Arg?Ala?Thr?Ala?Gly?Leu?Ile?Ile?Thr?Glu?Gly?Val?Gln?Pro?Ser
35 40 45
Ala?Thr?Gly?Gln?Gly?Tyr?Ser?Asn?Thr?Pro?Gly?Leu?His?Thr?Arg?Arg
50 55 60
Gln?Ile?Cys?Gly?Trp?Arg?Ala?Val?Ala?Asp?Gly?Val?His?Glu?Glu?Gly
65 70 75 80
Gly?His?Ile?Val?Ala?Gln?Ile?Met?His?Ala?Gly?Arg?Ile?Ala?His?Pro
85 90 95
Asp?Asn?Lys?Asn?Gly?His?Glu?Thr?Val?Ala?Pro?Ser?Ala?Leu?Ala?Ala
100 105 110
Pro?Gly?Glu?Ile?Phe?Thr?Pro?Ser?Gly?Pro?Arg?Pro?His?Pro?Val?Pro
115 120 125
Arg?Ala?Leu?Thr?Thr?Ala?Glu?Ile?Pro?Ser?Val?Ile?Glu?Glu?Tyr?Val
130 135 140
Asp?Ser?Ala?Arg?Ala?Ala?Val?Glu?Ala?Gly?Leu?Asp?Gly?Ile?Glu?Leu
145 150 155 160
His?Gly?Ala?Asn?Gly?Tyr?Leu?Ile?His?Gln?Phe?Leu?Ala?Pro?Ser?Thr
165 170 175
Asn?His?Arg?Thr?Asp?Thr?Tyr?Gly?Gly?Ser?Thr?Thr?Gly?Arg?Ala?Arg
180 185 190
Phe?Ala?Ile?Asp?Leu?Ala?Thr?Ala?Val?Ala?Glu?Ala?Val?Gly?Ser?Glu
195 200 205
Arg?Val?Gly?Leu?Arg?Ile?Ser?Pro?Gly?Ile?Asn?Leu?His?Gly?Ala?Thr
210 215 220
Glu?Asp?Asp?Pro?Ala?Glu?Thr?Ala?Ala?Thr?Tyr?Arg?Thr?Leu?Ile?Asp
225 230 235 240
Ala?Ile?Ala?Pro?Leu?Gly?Leu?Ala?Tyr?Leu?His?Thr?Ile?Gly?Asp?Pro
245 250 255
Ala?Thr?Pro?Leu?Leu?Thr?Asp?Leu?Arg?Thr?Arg?Phe?Asp?Gly?Thr?Leu
260 265 270
Ile?Val?Asn?Asp?Gly?Trp?Tyr?Pro?Met?Thr?Asp?Ala?Thr?Ala?Ala?Arg
275 280 285
Arg?His?Ile?Asp?Ser?Gly?Arg?Ala?Asp?Leu?Val?Ser?Val?Gly?Arg?Ala
290 295 300
Phe?Ile?Ala?Asn?Pro?Asp?Leu?Val?Arg?Arg?Trp?Gln?Asn?His?Thr?Pro
305 310 315 320
Val?Thr?Glu?Pro?Asp?Pro?Thr?Thr?Phe?Tyr?Gly?Gly?Asp?Thr?Arg?Gly
325 330 335
Tyr?Thr?Asp?Tyr?Thr?Thr?Leu?Ala?Asp
340 345
<210>26
<211>463
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>26
Met?His?Ala?Arg?Ala?Gln?His?Pro?Pro?Arg?His?Leu?Gly?Leu?Arg?Ala
1 5 10 15
Pro?Ile?Arg?Pro?Ser?Thr?Thr?Pro?Ala?Pro?Arg?Ala?Gly?Ser?Cys?Ser
20 25 30
His?Cys?Ser?Trp?Ala?Ser?Pro?Ala?Pro?Ser?Cys?Arg?Asn?Arg?Val?Thr
35 40 45
Ser?Phe?His?Arg?Pro?Gly?Asn?Ser?Ala?Ala?Ala?Pro?Gly?Asp?Arg?Arg
50 55 60
Pro?Ala?Leu?Leu?Pro?Gly?Pro?Glu?Ala?Ile?Arg?Asn?Leu?Ala?Glu?Thr
65 70 75 80
Ala?Trp?Phe?Leu?Gly?Thr?Gly?Gln?Val?Pro?Gly?Glu?Ala?Val?Gly?Met
85 90 95
Thr?Glu?Ile?Ala?Asn?Ser?Pro?Gly?Gly?Val?Asp?Thr?Glu?Val?Val?Gly
100 105 110
Asp?Ala?Asp?Val?Asp?Val?Val?Val?Val?Gly?Gly?Gly?Val?Ala?Gly?Leu
115 120 125
Ser?Gly?Ala?Val?Thr?Leu?Ala?Arg?Ser?Arg?Arg?Ser?Val?Val?Val?Ile
130 135 140
Asp?Ser?Gly?Glu?Pro?Arg?Asn?Ala?Pro?Ala?Ser?Gly?Val?His?Gly?Leu
145 150 155 160
Leu?Ser?Arg?Asp?Gly?Ile?Asn?Pro?Ser?Glu?Leu?Leu?Arg?Val?Gly?Arg
165 170 175
Glu?Glu?Val?Ile?Ser?Tyr?Gly?Gly?Arg?Met?Ile?Ser?Asp?Arg?Val?Val
180 185 190
Thr?Thr?Gly?Arg?Asp?Gly?Asp?Gly?Phe?Val?Val?Asp?Thr?Ala?Gly?Gly
195 200 205
His?Arg?Phe?Arg?Ala?Arg?Arg?Leu?Leu?Met?Cys?Thr?Gly?Leu?Val?Asp
210 215 220
Arg?Leu?Pro?Asp?Ile?Ala?Gly?Leu?Arg?Glu?Arg?Trp?Gly?Arg?Asp?Val
225 230 235 240
Leu?His?Cys?Pro?Tyr?Cys?His?Gly?Trp?Glu?Val?Arg?Asp?Gln?Pro?Val
245 250 255
Gly?Val?Leu?Ala?Thr?Gly?Pro?Ala?Ala?Val?His?Gln?Ala?Leu?Leu?Phe
260 265 270
Arg?Gln?Leu?Ser?Asp?Gln?Val?Thr?Leu?Phe?Arg?His?Ser?Ile?Gly?Glu
275 280 285
Leu?Gly?Val?Glu?Asp?Gly?Glu?Arg?Leu?Ala?Ala?Arg?Gly?Val?Ala?Val
290 295 300
Val?Glu?Gly?Asp?Val?Thr?Asp?Leu?Glu?Ile?Glu?Asp?Asp?Arg?Leu?Thr
305 310 315 320
Gly?Val?Arg?Leu?Ala?Ser?Gly?Asp?Arg?Ala?Pro?Leu?Ala?Ala?Leu?Val
325 330 335
Val?Ala?Pro?Arg?Phe?Glu?Ala?Arg?Asp?Asp?Val?Leu?Ala?Glu?Leu?Gly
340 345 350
Leu?Thr?Ala?Val?Glu?His?Pro?Trp?Ala?Ile?Gly?Asp?Gln?Val?Gly?Ala
355 360 365
Asp?Gly?Thr?Gly?Leu?Thr?Ala?Ala?Gly?Gly?Val?Trp?Val?Ala?Gly?Asn
370 375 380
Val?Ala?Asp?Val?Leu?Asp?Gly?Val?Pro?Ala?Ala?Ala?Ala?Ala?Gly?Val
385 390 395 400
Arg?Ala?Ala?Ala?Ala?Ile?Asn?Ala?Asp?Leu?Val?Ala?Ala?Asp?Thr?Asp
405 410 415
Ala?Ala?Leu?Ala?Arg?Arg?Arg?Thr?Arg?Ser?Val?Ala?Gly?Val?Phe?Thr
420 425 430
Pro?Glu?Ala?Glu?Ala?Ala?Leu?Cys?Glu?Gln?Val?Met?Gly?Glu?Arg?Arg
435 440 445
His?Gly?Leu?Asp?Gly?Leu?Leu?Pro?Leu?Gly?Pro?Ser?Gln?Gln?Gly
450 455 460
<210>27
<211>288
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>27
Val?Arg?Glu?Gly?Asp?Val?Asp?Asp?Gly?Gly?Val?Gln?His?His?His?Gln
1 5 10 15
Arg?Arg?His?Arg?Asp?His?Arg?Gln?Arg?Pro?Pro?Ala?Pro?Trp?Val?Gln
20 25 30
Ser?Val?Leu?Thr?Ala?Val?His?Arg?Val?Gly?Phe?Arg?Arg?His?Arg?Arg
35 40 45
Gly?Gln?Ser?Ser?Ala?Asp?Gln?Gly?Lys?Arg?Ala?Gly?His?Leu?Arg?Ala
50 55 60
Thr?Gly?Gln?Ser?Gly?Gly?Pro?Leu?Val?Arg?His?Cys?Asp?Gly?His?Cys
65 70 75 80
Trp?Ser?Cys?Lys?Ala?Ser?Cys?Cys?Phe?Ser?Met?Leu?Val?Gly?Met?Ser
85 90 95
Ala?Ala?Arg?His?Ile?Gly?Lys?Lys?Asp?Gly?Leu?Thr?Ala?Val?Gly?Pro
100 105 110
Arg?Leu?Arg?Asp?Leu?Arg?Arg?Arg?His?Gly?Leu?Thr?Leu?Ala?Ala?Leu
115 120 125
Ala?Gln?Gln?Thr?Gly?Ile?Asn?Glu?Ser?Thr?Leu?Ser?Arg?Leu?Glu?Gly
130 135 140
Gly?Ser?Arg?Lys?Pro?Thr?Leu?Glu?Met?Leu?Leu?Pro?Leu?Ala?Glu?Val
145 150 155 160
Tyr?Ala?Val?Pro?Leu?Asp?Glu?Leu?Val?Gly?Ala?Pro?Arg?Thr?Gly?Asp
165 170 175
Pro?Arg?Ile?His?Leu?Lys?Pro?Val?Val?Arg?Asp?Gly?Met?Thr?Tyr?Val
180 185 190
Pro?Leu?Ser?Arg?Pro?Gly?Gly?Val?Gln?Ala?His?Lys?Leu?Leu?Ile?Pro
195 200 205
Pro?Arg?Pro?Gly?Thr?Ala?Pro?His?Leu?Ser?Thr?His?Glu?Gly?Phe?Glu
210 215 220
Trp?Val?Tyr?Val?Leu?Ala?Gly?Arg?Leu?Arg?Leu?Leu?Leu?Gly?Glu?Glu
225 230 235 240
Arg?Val?Ile?Leu?Lys?Pro?Gly?Glu?Ala?Ala?Glu?Phe?Asn?Thr?His?Val
245 250 255
Pro?His?Trp?Leu?Gly?Pro?Asp?Asp?Asp?Arg?Thr?Val?Glu?Leu?Leu?Ile
260 265 270
Leu?Phe?Gly?Thr?Gln?Gly?Glu?Arg?Ala?His?Leu?Lys?Ala?Arg?Thr?Thr
275 280 285
<210>28
<211>473
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>28
Leu?Asp?Pro?Arg?Arg?Trp?Trp?Ala?Leu?Thr?Val?Ile?Ser?Val?Ala?Thr
1 5 10 15
Leu?Met?Val?Val?Leu?Asp?Ala?Ser?Val?Ile?Asn?Ile?Ala?Leu?Pro?His
20 25 30
Ala?Gln?Ala?Asp?Leu?Asp?Ile?Ser?Asp?Ala?Asn?Arg?Gln?Trp?Ala?Val
35 40 45
Thr?Ala?Tyr?Ala?Leu?Thr?Phe?Gly?Gly?Leu?Leu?Leu?Leu?Gly?Gly?Arg
50 55 60
Val?Val?Asp?Phe?Val?Gly?Arg?Lys?Arg?Val?Phe?Leu?Ile?Gly?Leu?Thr
65 70 75 80
Gly?Phe?Ala?Ala?Ala?Ser?Met?Leu?Ala?Gly?Ile?Ala?Pro?Asn?Gly?Met
85 90 95
Thr?Leu?Phe?Ala?Gly?Arg?Ala?Leu?Gln?Gly?Val?Phe?Ala?Ala?Leu?Leu
100 105 110
Ala?Pro?Ala?Ala?Leu?Ser?Leu?Ile?Ala?Val?Thr?Phe?Thr?Asp?Pro?Arg
115 120 125
Glu?Arg?Ala?Lys?Ala?Phe?Gly?Val?Tyr?Gly?Ala?Leu?Gln?Gly?Ala?Gly
130 135 140
Gly?Ala?Val?Gly?Leu?Ile?Ala?Gly?Gly?Leu?Leu?Thr?Glu?Tyr?Thr?Ser
145 150 155 160
Trp?Arg?Trp?Cys?Leu?Phe?Val?Asn?Thr?Pro?Ile?Ala?Leu?Ala?Met?Ala
165 170 175
Leu?Ala?Ala?Leu?Pro?Val?Leu?Lys?Glu?Ser?Arg?Ala?Glu?Gly?Thr?Arg
180 185 190
Arg?Tyr?Asp?Ile?Pro?Gly?Ala?Leu?Leu?Val?Thr?Thr?Gly?Leu?Val?Ala
195 200 205
Ile?Val?Trp?Gly?Phe?Thr?His?Ala?Ala?Glu?Ala?Gly?Trp?Asn?Thr?Pro
210 215 220
Ala?Thr?Trp?Leu?Leu?Leu?Thr?Ala?Gly?Leu?Ala?Leu?Leu?Ala?Ser?Phe
225 230 235 240
Val?Leu?Val?Glu?Arg?Arg?Thr?Ala?His?Pro?Leu?Leu?Pro?Leu?Arg?Val
245 250 255
Ile?Trp?Asp?Arg?Asp?Arg?Gly?Gly?Ala?Phe?Leu?Ala?Ser?Leu?Leu?Ile
260 265 270
Gly?Ala?Gly?Met?Phe?Gly?Leu?Leu?Leu?Phe?Leu?Thr?Tyr?Tyr?Leu?Gln
275 280 285
Val?Asn?Leu?Gly?Tyr?Gln?Pro?Leu?Arg?Ala?Gly?Leu?Ala?Phe?Leu?Pro
290 295 300
Phe?Ser?Ala?Gly?Ile?Ile?Ala?Ala?Ala?Thr?Phe?Gly?Ala?Pro?Leu?Val
305 310 315 320
Thr?Arg?Leu?Gly?Pro?Lys?Thr?Leu?Met?Thr?Ala?Gly?Thr?Ala?Val?Thr
325 330 335
Leu?Ala?Gly?Thr?Leu?Val?Leu?Thr?Leu?Leu?Lys?Pro?Thr?Glu?Gly?Tyr
340 345 350
Met?Thr?Val?Val?Leu?Pro?Ala?Met?Ile?Leu?Thr?Gly?Leu?Gly?Leu?Gly
355 360 365
Ala?Phe?Phe?Val?Ala?Leu?Pro?Asn?Thr?Ala?Leu?Ala?Gly?Ile?Ala?Pro
370 375 380
Ser?Asp?Thr?Gly?Val?Ala?Ser?Ala?Met?Ile?Ser?Thr?Thr?Gln?Gln?Val
385 390 395 400
Gly?Gly?Ala?Val?Gly?Pro?Ala?Leu?Leu?Asn?Thr?Leu?Tyr?Val?Ser?Ala
405 410 415
Leu?Thr?Gly?Phe?Leu?Ala?Asp?Arg?Thr?Gly?Ala?Val?Ser?Gln?Ala?Val
420 425 430
Arg?Leu?Glu?Gly?Tyr?Val?His?Gly?Tyr?Arg?Val?Ala?Phe?Leu?Ala?Ser
435 440 445
Ala?Ala?Leu?Phe?Ala?Leu?Ala?Leu?Ala?Ala?Ala?Gly?Leu?Leu?Ile?Thr
450 455 460
Ser?Arg?Arg?Thr?Ser?Ala?Ala?Thr?Ser
465 470
<210>29
<211>210
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>29
Met?Asn?Ser?Ala?Asn?Glu?Ser?Ala?Thr?Phe?Trp?Glu?Lys?His?Tyr?Ala
1 5 10 15
Ser?Met?Asp?Ala?Gln?Trp?Gly?Thr?Lys?Pro?Asn?Ala?Val?Leu?Thr?Ala
20 25 30
Leu?Leu?Ala?Asp?Leu?Ala?Pro?Ala?Pro?Gly?Thr?Ala?Leu?Asp?Leu?Gly
35 40 45
Cys?Gly?His?Gly?Gly?Asp?Ala?Leu?Trp?Leu?Ala?Ala?Gln?Gly?Trp?Asp
50 55 60
Val?Thr?Pro?Val?Asp?Val?Ser?Gln?Thr?Ala?Leu?Asp?Arg?Val?Ala?Ala
65 70 75 80
Gly?Ala?Ala?Ala?Thr?Gly?Leu?Thr?Asp?Arg?Val?His?Pro?Gln?Gln?His
85 90 95
Asp?Leu?Ser?Glu?Thr?Phe?Pro?Asp?Gly?Ala?Trp?Asp?Leu?Val?Thr?Ala
100 105 110
Thr?Tyr?Phe?His?Thr?Pro?Val?Thr?Ile?Ala?Arg?Asp?Ser?Val?Leu?Arg
115 120 125
Arg?Ala?Ala?Gln?Ala?Val?Ala?Pro?Gly?Gly?Arg?Leu?Ile?Val?Ile?Glu
130 135 140
His?Ala?Ser?Thr?Ala?Pro?Trp?Ser?Trp?Gln?Ala?Gly?Gln?Asp?Ile?Arg
145 150 155 160
Tyr?Pro?Thr?Pro?Asp?Asp?Val?Ile?Ala?Ser?Leu?Gln?Leu?Asp?Asp?Thr
165 170 175
Trp?Ala?Val?Glu?Arg?Gly?Asp?Ala?Pro?Gln?Arg?Thr?Ala?Ala?Gly?Pro
180 185 190
Glu?Gly?Gln?Thr?Ala?Thr?Val?Thr?Asp?Asn?Val?Ile?Ala?Val?Arg?Arg
195 200 205
Thr?Ser
210
<210>30
<211>221
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>30
Val?Ala?Thr?Leu?Lys?Thr?Pro?Glu?Gly?Ser?Arg?Phe?Ser?Glu?Leu?Glu
1 5 10 15
Arg?Leu?Arg?Arg?Pro?Pro?Thr?Arg?Thr?Thr?Gly?Thr?Ala?Phe?Ala?Arg
20 25 30
Ala?Leu?Glu?Arg?Val?Asp?Glu?Ile?Gly?Ala?Tyr?Arg?Leu?Gly?Arg?Leu
35 40 45
Arg?Leu?Ser?Gln?Ile?Pro?Pro?Asn?Arg?Met?Ala?Ala?Leu?Ala?Arg?Tyr
50 55 60
Ala?Leu?Gly?Ser?Lys?Ala?Pro?Leu?Leu?Glu?Arg?Ala?Gln?Glu?Pro?Lys
65 70 75 80
Arg?Thr?Ala?Met?Leu?Thr?Ala?Val?Met?Arg?His?Leu?Glu?Ala?Lys?Ala
85 90 95
Ile?Asp?Glu?Ala?Leu?Asp?Leu?Phe?Gln?Val?Leu?Met?Ala?Thr?Arg?Leu
100 105 110
Leu?Asn?Thr?Ala?Lys?Arg?Lys?Thr?Glu?Lys?Glu?Arg?Leu?Ser?Thr?Leu
115 120 125
Pro?Gln?Leu?Glu?Lys?Ala?Ser?Arg?Val?Leu?Ala?Arg?Ala?Ala?Lys?Ala
130 135 140
Leu?Leu?Glu?Glu?Leu?Glu?Leu?Val?Glu?Glu?His?Glu?Ala?Asp?Leu?Asp
145 150 155 160
Val?Ala?Ala?Leu?Trp?Ala?Ala?Val?Pro?Gly?Thr?Pro?Arg?Asp?Ser?Leu
165 170 175
Ser?Pro?Leu?Lys?His?Arg?Asn?Leu?Asn?Leu?Leu?Gly?Arg?Tyr?Ser?Phe
180 185 190
Thr?Ala?Ser?Thr?Pro?Ala?Ala?Gly?Ala?Leu?Arg?Pro?Leu?Arg?Asn?Pro
195 200 205
Asp?Gly?Pro?Glu?Leu?Asp?Asp?Asp?Asp?Asp?Gly?Ala?Gly
210 215 220
<210>31
<211>202
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>31
Val?Glu?Phe?Leu?Thr?Asp?Glu?Gln?Ala?Glu?Ala?Tyr?Gly?Lys?Phe?Ala
1 5 10 15
Glu?Glu?Pro?Thr?Arg?Pro?Glu?Leu?Glu?Arg?Phe?Phe?Phe?Leu?Asp?Asp
20 25 30
Val?Asp?Arg?Asp?Leu?Ile?Ala?Arg?Arg?Arg?Ser?Thr?Tyr?His?Gln?Leu
35 40 45
Gly?Phe?Ala?Leu?Gln?Met?Cys?Thr?Val?Arg?Tyr?Ile?Gly?Arg?Phe?Leu
50 55 60
Pro?Asp?Asp?Pro?Leu?Asp?Ala?Pro?Trp?Pro?Val?Val?Glu?His?Leu?Ala
65 70 75 80
Ala?Gln?Leu?Gly?Ile?Glu?Asp?Pro?Ser?Val?Val?Lys?Arg?Tyr?Thr?Glu
85 90 95
Arg?Pro?Lys?Thr?Ala?Tyr?Glu?His?Ala?Trp?Glu?Ile?Arg?Asp?Ala?Tyr
100 105 110
Glu?Tyr?His?Glu?Tyr?Asp?Asp?Pro?Glu?Trp?Ser?Arg?Arg?Phe?Arg?Thr
115 120 125
Phe?Leu?His?Gly?Arg?Ala?Trp?Thr?His?Ala?Glu?Gly?Pro?Lys?Ala?Leu
130 135 140
Phe?Asp?His?Ala?Val?Gly?Trp?Leu?Arg?Arg?Asn?Arg?Val?Leu?Leu?Pro
145 150 155 160
Gly?Val?Ser?Val?Leu?Ala?Arg?Gln?Val?Ser?Glu?Val?Arg?Lys?Val?Ala
165 170 175
Glu?Lys?Arg?Leu?His?Ala?Thr?Val?Arg?Ala?Arg?Pro?Ala?Ala?Arg?Thr
180 185 190
Arg?Arg?Phe?Pro?Gly?Thr?Trp?Trp?Arg?Arg
195 200
<210>32
<211>139
<212>PRT
＜213〉white light gray streptomycete 1-36 (Streptomyces albogriseolus sp.1-36)
<400>32
Val?Cys?Ser?Glu?Val?Arg?Pro?Gly?Asp?Arg?Phe?Asp?Glu?Ala?Arg?Leu
1 5 10 15
Lys?Leu?Leu?Thr?Gly?Gly?Asp?Arg?Ile?Lys?Ala?Arg?Arg?Met?Arg?Gln
20 25 30
Asp?Phe?Phe?Ser?Phe?Glu?Pro?Thr?His?Lys?Leu?Trp?Leu?Leu?Gly?Asn
35 40 45
His?Arg?Pro?Glu?Val?Gly?Thr?Gly?Gly?Phe?Ala?Phe?Trp?Arg?Arg?Met
50 55 60
Arg?Leu?Ile?Pro?Phe?Asp?Arg?Val?Val?Pro?Asp?Asp?Arg?Arg?Ile?Asp
65 70 75 80
Asn?Leu?Ala?Asp?Val?Leu?Val?Arg?Glu?Glu?Gly?Pro?Gly?Ile?Leu?His
85 90 95
Trp?Leu?Val?Leu?Gly?Ala?Arg?Arg?Tyr?Leu?Ala?Gly?Ala?Arg?Asp?Leu
100 105 110
Val?Gly?Pro?Glu?Arg?Val?Arg?Val?Ala?Thr?Ala?Ala?Tyr?Ala?Gln?Thr
115 120 125
Gly?Leu?Gly?Glu?His?Arg?Tyr?Ser?Gly?Trp?Arg
130 135

Claims (6)

1. white light gray streptomycete Streptomyces albogriseolus sp.1-36, the microbial strains preserving number is (CGMCCNO.3406), it is characterized in that, its genome contains a kind of halogenated AMSA microbiotic synthetic gene bunch.
2. a halogenated AMSA microbiotic synthetic gene bunch is characterized in that its gene order is SEQ ID NO 1.
3. a kind of halogenated microbiotic synthetic gene as claimed in claim 2 bunch is characterized in that this gene cluster total length is 81061 base pairs, contains 31 open reading frame, and composition comprises:
1) ORF1: be positioned at the nucleotide sequence 157-16584 base place of gene cluster, length 16431 base pairs, 5476 amino acid of encoding;
2) ORF2: be positioned at the nucleotide sequence 16621-27498 base place of gene cluster, length 10881 base pairs, 3626 amino acid of encoding;
3) ORF3: be positioned at the nucleotide sequence 27535-38376 base place of gene cluster, length 10845 base pairs, 3614 amino acid of encoding;
4) ORF4: be positioned at the nucleotide sequence 38471-44089 base place of gene cluster, length 5622 base pairs, 1873 amino acid of encoding;
5) ORF5: be positioned at the nucleotide sequence 44143-54915 base place of gene cluster, length 10776 base pairs, 3591 amino acid of encoding;
6) ORF6: be positioned at the nucleotide sequence 54953-55729 base place of gene cluster, length 780 base pairs, 259 amino acid of encoding;
7) ORF7: be positioned at the nucleotide sequence 55930-57177 base place of gene cluster, length 1251 base pairs, 416 amino acid of encoding;
8) ORF8: be positioned at the nucleotide sequence 57190-58257 base place of gene cluster, length 1071 base pairs, 356 amino acid of encoding;
9) ORF9: be positioned at the nucleotide sequence 58257-59591 base place of gene cluster, length 1338 base pairs, 445 amino acid of encoding;
10) ORF10: be positioned at the nucleotide sequence 59591-60400 base place of gene cluster, length 813 base pairs, 270 amino acid of encoding;
11) ORF11: be positioned at the nucleotide sequence 60432-61682 base place of gene cluster, length 1254 base pairs, 417 amino acid of encoding;
12) ORF12: be positioned at the nucleotide sequence 61682-62767 base place of gene cluster, length 1089 base pairs, 362 amino acid of encoding;
13) ORF13: be positioned at the nucleotide sequence 62786-63517 base place of gene cluster, length 735 base pairs, 244 amino acid of encoding;
14) ORF14: be positioned at the nucleotide sequence 63513-64412 base place of gene cluster, length 903 base pairs, 300 amino acid of encoding;
15) ORF15: be positioned at the nucleotide sequence 66182-64524 base place of gene cluster, length 1662 base pairs, 553 amino acid of encoding;
16) ORF16: be positioned at the nucleotide sequence 66522-66331 base place of gene cluster, length 195 base pairs, 64 amino acid of encoding;
17) ORF17: be positioned at the nucleotide sequence 66852-67634 base place of gene cluster, length 786 base pairs, 261 amino acid of encoding;
18) ORF18: be positioned at the nucleotide sequence 67639-68973 base place of gene cluster, length 1338 base pairs, 445 amino acid of encoding;
19) ORF19: be positioned at the nucleotide sequence 68997-9836 base place of gene cluster, length 843 base pairs, 280 amino acid of encoding;
20) ORF20: be positioned at the nucleotide sequence 71184-69868 base place of gene cluster, length 1320 base pairs, 439 amino acid of encoding;
21) ORF21: be positioned at the nucleotide sequence 71485-71916 base place of gene cluster, length 435 base pairs, 144 amino acid of encoding;
22) ORF22: be positioned at the nucleotide sequence 72276-71935 base place of gene cluster, length 345 base pairs, 114 amino acid of encoding;
23) ORF23: be positioned at the nucleotide sequence 73156-72242 base place of gene cluster, length 918 base pairs, 305 amino acid of encoding;
24) ORF24: be positioned at the nucleotide sequence 74535-73501 base place of gene cluster, length 1038 base pairs, 345 amino acid of encoding;
25) ORF25: be positioned at the nucleotide sequence 76197-74809 base place of gene cluster, length 1392 base pairs, 463 amino acid of encoding;
26) ORF26: be positioned at the nucleotide sequence 77125-76262 base place of gene cluster, length 867 base pairs, 288 amino acid of encoding;
27) ORF27: be positioned at the nucleotide sequence 77030-78448 base place of gene cluster, length 1422 base pairs, 473 amino acid of encoding;
28) ORF28: be positioned at the nucleotide sequence 78477-79106 base place of gene cluster, length 633 base pairs, 210 amino acid of encoding;
29) ORF29: be positioned at the nucleotide sequence 79857-79195 base place of gene cluster, length 666 base pairs, 221 amino acid of encoding;
30) ORF30: be positioned at the nucleotide sequence 80453-79848 base place of gene cluster, length 609 base pairs, 202 amino acid of encoding;
31) ORF31: be positioned at the nucleotide sequence 80974-80558 base place of gene cluster, length 420 base pairs, 139 amino acid of encoding.
4. the method for a screening halogenated microbiotic synthetic gene bunch is characterized in that, may further comprise the steps:
Step 1, the gene clone of halo enzyme: use the primer at halo enzymic synthesis gene design that bacterial strain DNA to be selected is carried out pcr amplification, the fragment that the positive is increased checks order, and submits to ncbi database to compare, and whether prove conclusively it is halo enzyme gene fragment;
Step 2, AMSA antibiotic resistance gene bunch screening: use degenerate primer that bacterial strain DNA to be selected is carried out pcr amplification at AMSA microbiotic biosynthesizing precursor 3-amino-5-hydroxy-benzoic acid (AHBA) synthetic enzyme and polyketide synthase PKS gene design, the fragment of positive amplification is checked order, and submit to database to compare, determine to have the AMSA biological synthesis gene cluster in this strain gene group;
Step 3 is cloned complete AMSA antibiotic resistance gene bunch: the Fosmid library that makes up the strain gene group; Utilize step 1 and two primers that use that genomic library is screened, determine that the external source insertion sequence carries AMSA microbiotic biosynthesis gene Fosmid; Checked order and restriction analysis in above-mentioned Fosmid two ends, determine can the antibiotic biological synthesis gene cluster of complete covering bacterial strain 1-36 halo AMSA by stack plasmid external source insertion fragment;
Step 4, the note of halo AMSA microbiotic biological synthesis gene cluster: the complete sequence of the Fosmid that step 3 is obtained carries out sequencing analysis, and splicing obtains complete halo AMSA microbiotic biological synthesis gene cluster; Utilize the online ORF forecasting tool FramePlot 3.0beta that designs at high GC microorganism specially that biological synthesis gene cluster is analyzed, obtain all to read the information of frame.
5. the purposes of a kind of white light gray streptomycete as claimed in claim 1 is characterized in that, is used to produce halo AMSA microbiotic.
6. the purposes of halo AMSA microbiotic synthetic gene as claimed in claim 2 bunch is characterized in that, is used to produce halo AMSA microbiotic, and improves its meta-bolites output by genetic engineering means.
CN2009102257692A 2009-12-03 2009-12-03 Biosynthetic gene clusters of halogen-containing ansamycins Pending CN102086442A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106916834A (en) * 2015-12-24 2017-07-04 武汉臻智生物科技有限公司 The biological synthesis gene cluster of compound and its application

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106916834A (en) * 2015-12-24 2017-07-04 武汉臻智生物科技有限公司 The biological synthesis gene cluster of compound and its application
CN106916834B (en) * 2015-12-24 2022-08-05 武汉合生科技有限公司 Biosynthetic gene cluster of compounds and application thereof

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