CN102083450A - 致病性构象异构体的分析 - Google Patents

致病性构象异构体的分析 Download PDF

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Publication number
CN102083450A
CN102083450A CN2009801159116A CN200980115911A CN102083450A CN 102083450 A CN102083450 A CN 102083450A CN 2009801159116 A CN2009801159116 A CN 2009801159116A CN 200980115911 A CN200980115911 A CN 200980115911A CN 102083450 A CN102083450 A CN 102083450A
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CN
China
Prior art keywords
reagent
pathogenic
pathogenic conformer
protein
conformer
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Pending
Application number
CN2009801159116A
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English (en)
Chinese (zh)
Inventor
D·佩列兹
X·王
M·(C·)高
A·杨
A·刘
P·吴
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Novartis Vaccines and Diagnostics Inc
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Novartis Vaccines and Diagnostics Inc
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Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of CN102083450A publication Critical patent/CN102083450A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2009801159116A 2008-04-30 2009-04-29 致病性构象异构体的分析 Pending CN102083450A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4939608P 2008-04-30 2008-04-30
US61/049,396 2008-04-30
PCT/US2009/042185 WO2009134942A1 (en) 2008-04-30 2009-04-29 Assay for pathogenic conformers

Publications (1)

Publication Number Publication Date
CN102083450A true CN102083450A (zh) 2011-06-01

Family

ID=40863365

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801159116A Pending CN102083450A (zh) 2008-04-30 2009-04-29 致病性构象异构体的分析

Country Status (8)

Country Link
US (1) US20110189692A1 (https=)
EP (1) EP2282753A1 (https=)
JP (1) JP2011520108A (https=)
CN (1) CN102083450A (https=)
AU (1) AU2009243060A1 (https=)
BR (1) BRPI0910550A2 (https=)
CA (1) CA2721982A1 (https=)
WO (1) WO2009134942A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113677993A (zh) * 2019-03-29 2021-11-19 积水医疗株式会社 免疫测定试剂和免疫测定方法

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US20130273573A1 (en) * 2009-11-30 2013-10-17 Novartis Ag Amyloid beta aggregates in cerebro spinal fluid as biomarkers for alzheimer's disease
JP5747444B2 (ja) * 2010-04-27 2015-07-15 パナソニックヘルスケア株式会社 βアミロイドに関連する病的状態の診断補助方法
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
JP2013227243A (ja) * 2012-04-25 2013-11-07 Shiga Univ Of Medical Science アミロイドβ蛋白凝集体結合化合物とその用途
GB201513444D0 (en) * 2015-07-30 2015-09-16 Univ Durham Peptoid
GB201518675D0 (en) 2015-10-21 2015-12-02 Cellcap Technologies Ltd Detection of structural forms of proteins
CA3006748A1 (en) * 2015-12-15 2017-06-22 Sarepta Therapeutics, Inc. Peptide oligonucleotide conjugates
EP3426672B1 (en) 2016-03-09 2021-09-01 Mike-Ann, LLC Peptoid affinity ligands

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WO2007030804A1 (en) * 2005-09-09 2007-03-15 Novartis Ag Prion-specific peptoid reagents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113677993A (zh) * 2019-03-29 2021-11-19 积水医疗株式会社 免疫测定试剂和免疫测定方法

Also Published As

Publication number Publication date
AU2009243060A1 (en) 2009-11-05
CA2721982A1 (en) 2009-11-05
EP2282753A1 (en) 2011-02-16
WO2009134942A1 (en) 2009-11-05
US20110189692A1 (en) 2011-08-04
JP2011520108A (ja) 2011-07-14
BRPI0910550A2 (pt) 2015-09-29

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Address after: Basel

Applicant after: Novartis Ag

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Application publication date: 20110601