CN102078550A - Chinese herbal medicine extract preparation for preventing and treating mycoplasma gallisepticum and preparation method thereof - Google Patents
Chinese herbal medicine extract preparation for preventing and treating mycoplasma gallisepticum and preparation method thereof Download PDFInfo
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- CN102078550A CN102078550A CN201010613997XA CN201010613997A CN102078550A CN 102078550 A CN102078550 A CN 102078550A CN 201010613997X A CN201010613997X A CN 201010613997XA CN 201010613997 A CN201010613997 A CN 201010613997A CN 102078550 A CN102078550 A CN 102078550A
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Abstract
The invention provides a Chinese herbal medicine extract preparation for preventing and treating mycoplasma gallisepticum and a preparation method thereof. The preparation method comprises the following steps: sorting loquat leaf, houttuynia, Chinese yam, isatis, licorice, coptis, stemona, white swallowwort and venenum bufonis; carrying out ultra-fine pulverization; soaking and extracting; soaking and extracting for the second time; mixing liquid medicines; concentrating; filtering; and respectively packaging to obtain the Chinese herbal medicine extract preparation. The Chinese herbal medicine extract preparation is concretely prepared from the following traditional Chinese medicines in parts by weight: 25-35 parts of loquat leaf, 15-25 parts of houttuynia, 18-22 parts of Chinese yam, 12-18 parts of isatis, 12-18 parts of licorice, 8-12 parts of coptis, 7-13 parts of stemona, 10-20 parts of white swallowwort and 0.3-0.8 part of venenum bufonis. The product provided by the invention is diluted with clear water according to the ratio of 1:100 to be fed to chickens twice a day continuously for 3-5 days, thereby effectively controlling mycoplasma gallisepticum infection. The Chinese herbal medicine extract preparation provided by the invention is convenient to use and has the advantages of low cost, no residues and high biological safety.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine extract preparation of preventing and treating respiratory disease of chicken and preparation method thereof, especially a kind of Chinese herbal medicine extract preparation of preventing and treating mycoplasma gallinarum and preparation method thereof.
Background technology
The mycoplasma gallinarum disease is a kind of contact, chronic infectious disease, primary disease sickness rate height, all can take place throughout the year, can be by vertical transmission and horizontal transmission.Under cold and hot extreme weather conditions, particularly the chicken population density is excessive, coop ventilation is bad, chickling disconnected beak, vaccine immunity, exist under the situations such as accompanying infection and malnutrition and take place, and mainly is to cause chronic respiratory tract disease, airsacculitis, sinusitis and synovitis.This disease is popular at home more extensive, because mycoplasma has more than 20 serotype, and does not have cell wall, has only the single cell film of three-decker.In general, it is to acting on the biosynthesis antibiotics of cell wall, insensitive fully as beta-lactam, vancomycin etc., to polymyxin, rifampicin, the general drug resistance of sulfonamide, other antibiotics such as aminoglycoside, chloromycetin have less inhibitory action to mycoplasma, it is Tetracyclines, Macrolide and some quinolones that mycoplasma is had the antibiotics that suppresses active and be usually used in mycoplasma infection most, yet long-term a large amount of use easily causes problems such as drug residue, drug resistance.Thereby the preparation of exploitation safety, high-efficiency prevention and control mycoplasma gallinarum has market prospect preferably.
Summary of the invention
Technical problem to be solved by this invention provides a kind of efficient, the safety of mycoplasma gallinarum, Chinese herbal medicine extract preparation of noresidue and preparation method thereof prevented and treated.
The scheme of technical problem to be solved by this invention is:
A kind of Chinese herbal medicine extract preparation of preventing and treating mycoplasma gallinarum, its constituent weight proportion scope is: 25～35 parts of Folium Eriobotryaes, 15～25 parts of Herba Houttuyniae, 18～22 parts of Rhizoma Dioscoreaes, 12～18 parts of Radix Isatidis, 12～18 parts in Radix Glycyrrhizae, 8～12 parts of Rhizoma Coptidis, 7～13 parts of the Radixs Stemonae, 10～20 parts of Rhizoma Cynanchi Stauntoniis, 0.3～0.8 part of Venenum Bufonis, its processing technology is: 1. letter sorting, 2. micronizing, 3. soak to extract, 4. secondary soak extract, 5. admixing medical solutions, 6. concentrate, 7. filter, 8. packing.
The technical scheme of technical problem to be solved by this invention can also be:
Constituent of the present invention weight proportion commonly used is: 30 parts of Folium Eriobotryaes, 20 parts of Herba Houttuyniae, 20 parts of Rhizoma Dioscoreaes, 15 parts of Radix Isatidis, 15 parts in Radix Glycyrrhizae, 10 parts of Rhizoma Coptidis, 10 parts of the Radixs Stemonae, 15 parts of Rhizoma Cynanchi Stauntoniis, 0.5 part of Venenum Bufonis, its processing technology is: 1. letter sorting, 2. micronizing, 3. soak extract, 4. secondary soak extract, 5. admixing medical solutions, 6. concentrate, 7. filter, 8. packing.
The impurity in each component is promptly removed in letter sorting of the present invention; Described micronizing promptly is ground into 200 purpose fine powders with above-mentioned each component weighing and after mixing respectively; Described immersion is extracted, and the medicated powder that is about to crush soaked 3 hours down with the clear water room temperature of 5 times of drug weight; Described secondary soaks and extracts, and is about to soak for the first time the clear water room temperature that extracts 5 times of former medicated powder weight of the isolated medicine residue reuse in back and soaks 3 hours down; Described admixing medical solutions is about to soak for the first time and for the second time the extracting solution that extracts gained and mixes; Described concentrating, the medicinal liquid that is about to extract is condensed into the concentrated solution of 1 times of former medicated powder weight.
The invention has the beneficial effects as follows:
But 1 specificity suppresses to kill mycoplasma gallinarum;
2, drinking-water administration, easy to use, cost is low;
3, because the present invention is a Chinese herbal and crude drugs preparations, therefore, in the noresidue of chicken body, bio-safety degree height.
Using method of the present invention is: product of the present invention is drunk to chicken with clear water dilution back in 1: 100 ratio, and 2 times on the one, logotype 3～5 days can effectively be controlled mycoplasma gallinarum and infect.
The specific embodiment:
Below be embodiments of the invention, the actual use of the present invention is not limited to embodiment.
Embodiment one:
Adopt the preparation method of the Chinese herbal medicine extract preparation of control mycoplasma gallinarum of the present invention to prepare this Chinese herbal medicine extract preparation, get crude drug 135.5kg altogether, the weight of each crude drug is respectively: Folium Eriobotryae 30kg, Herba Houttuyniae 20kg, Rhizoma Dioscoreae 20kg, Radix Isatidis 15kg, Radix Glycyrrhizae 15kg, Rhizoma Coptidis 10kg, Radix Stemonae 10kg, Rhizoma Cynanchi Stauntonii 15kg, Venenum Bufonis 0.5kg.Be broken into 200 purpose fine powders through letter sorting, superfine powder, the clear water room temperature that is 677.5kg with 5 times of drug weight with the medicated powder that crushes soaked 3 hours down, separate medicinal liquid and medicine residue, it is standby to leave and take medicinal liquid, the clear water room temperature that isolated medicine residue is added 5 times of former medicated powder weight soaked 3 hours down again, isolated medicinal liquid, was condensed into the concentrated solution of 1 times of former medicated powder weight after the medicinal liquid mixing with extracted twice, filter, packing makes finished product.
8300 broiler in one broiler chicken farm, Linyi, Shandong, having 30% chicken nose liquid to occur increases, effusive serosity nose liquid is stained with around the nostril and the cervical region feather, the sick chicken sneeze of often shaking the head, dyspnea, cough, asthma, mouth breathing also can be heard tracheal sound, sick chicken essence god is tired, loss of appetite, growth retardation, progressive becoming thin, rhinitis and conjunctivitis take place in the sick chicken that has, and eyelid swelling binds, symptoms such as exophthalmos, according to epidemiology, clinical symptoms, cut open that inspection changes and etiological examination determines that the chicken mass-sending given birth to mycoplasma infection, the Chinese herbal medicine extract preparation that the application said method makes is treated with the clear water dilution in 1: 100 ratio, and one day 2 times, logotype 5 days.Medication after 2 days symptom obviously alleviate, whole chicken group's spirit after 4 days, search for food, drink water and all recover normal, the state of an illness has obtained effective control.
Embodiment two:
Adopt the preparation method of the Chinese herbal medicine extract preparation of control mycoplasma gallinarum of the present invention to prepare this Chinese herbal medicine extract preparation, get crude drug 107.3kg altogether, the weight of each crude drug is respectively: Folium Eriobotryae 25kg, Herba Houttuyniae 15kg, Rhizoma Dioscoreae 18kg, Radix Isatidis 12kg, Radix Glycyrrhizae 12kg, Rhizoma Coptidis 8kg, Radix Stemonae 7kg, Rhizoma Cynanchi Stauntonii 10kg, Venenum Bufonis 0.3kg.Be broken into 200 purpose fine powders through letter sorting, superfine powder, the clear water room temperature that is 536.5kg with 5 times of drug weight with the medicated powder that crushes soaked 3 hours down, separate medicinal liquid and medicine residue, it is standby to leave and take medicinal liquid, the clear water room temperature that isolated medicine residue is added 5 times of former medicated powder weight soaked 3 hours down again, isolated medicinal liquid, was condensed into the concentrated solution of 1 times of former medicated powder weight after the medicinal liquid mixing with extracted twice, filter, packing makes finished product.
Mycoplasma infection takes place to one laying hen field, Suining, Xuzhou in 5000 laying hens, the Chinese herbal medicine extract preparation that the application said method makes was drunk every day 2 times, logotype 5 days to chicken behind the thin up according to 1: 100, the 3rd day 80% sick chicken symptom obviously alleviates after the medication, and the state of an illness was controlled in the 5th day.
Embodiment three:
Adopt the preparation method of the Chinese herbal medicine extract preparation of control mycoplasma gallinarum of the present invention to prepare this Chinese herbal medicine extract preparation, get crude drug 163.8kg altogether, the weight of each crude drug is respectively: Folium Eriobotryae 35kg, Herba Houttuyniae 25kg, Rhizoma Dioscoreae 22kg, Radix Isatidis 18kg, Radix Glycyrrhizae 18kg, Rhizoma Coptidis 12kg, Radix Stemonae 13kg, Rhizoma Cynanchi Stauntonii 20kg, Venenum Bufonis 0.8kg.Be broken into 200 purpose fine powders through letter sorting, superfine powder, the clear water room temperature that is 819kg with 5 times of drug weight with the medicated powder that crushes soaked 3 hours down, separate medicinal liquid and medicine residue, it is standby to leave and take medicinal liquid, the clear water room temperature that isolated medicine residue is added 5 times of former medicated powder weight soaked 3 hours down again, isolated medicinal liquid, was condensed into the concentrated solution of 1 times of former medicated powder weight after the medicinal liquid mixing with extracted twice, filter, packing makes finished product.
When mycoplasma infection took place in oil mill town grand celebration laying hen field during raised in Jiangsu, the Chinese herbal medicine extract preparation of the control mycoplasma gallinarum that the application said method makes was drunk to chicken behind the thin up according to 1: 100, and every day 2 times, epidemic situation has just been controlled in logotype 4 days well.
Claims (3)
1. Chinese herbal medicine extract preparation of preventing and treating mycoplasma gallinarum, it is characterized in that: its constituent ratio range is: 25～35 parts of Folium Eriobotryaes, 15～25 parts of Herba Houttuyniae, 18～22 parts of Rhizoma Dioscoreaes, 12～18 parts of Radix Isatidis, 12～18 parts in Radix Glycyrrhizae, 8～12 parts of Rhizoma Coptidis, 7～13 parts of the Radixs Stemonae, 10～20 parts of Rhizoma Cynanchi Stauntoniis, 0.3～0.8 part of Venenum Bufonis.Its processing technology is: 1. letter sorting, 2. micronizing, 3. soak to extract, 4. secondary soak extract, 5. admixing medical solutions, 6. concentrate, 7. filter, 8. packing.
2. a kind of Chinese herbal medicine extract preparation of preventing and treating mycoplasma gallinarum according to claim 1 is characterized in that: its constituent weight proportion commonly used is: 30 parts of Folium Eriobotryaes, 20 parts of Herba Houttuyniae, 20 parts of Rhizoma Dioscoreaes, 15 parts of Radix Isatidis, 15 parts in Radix Glycyrrhizae, 10 parts of Rhizoma Coptidis, 10 parts of the Radixs Stemonae, 15 parts of Rhizoma Cynanchi Stauntoniis, 0.5 part of Venenum Bufonis.
3. according to claim 1 and 2 described a kind of Chinese herbal medicine extract preparations of preventing and treating mycoplasma gallinarum, it is characterized in that: described letter sorting, promptly remove the impurity in each component; Described micronizing promptly is ground into 200 purpose fine powders with above-mentioned each component weighing and after mixing respectively; Described immersion is extracted, and the medicated powder that is about to crush soaked 3 hours down with the clear water room temperature of 5 times of drug weight; Described secondary soaks and extracts, and is about to soak for the first time the clear water room temperature that extracts 5 times of former medicated powder weight of the isolated medicine residue reuse in back and soaks 3 hours down; Described admixing medical solutions is about to soak for the first time and for the second time the extracting solution that extracts gained and mixes; Described concentrating, the medicinal liquid that is about to extract is condensed into the concentrated solution of 1 times of former medicated powder weight.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010613997XA CN102078550B (en) | 2010-12-30 | 2010-12-30 | Chinese herbal medicine extract preparation for preventing and treating mycoplasma gallisepticum and preparation method thereof |
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| CN201010613997XA CN102078550B (en) | 2010-12-30 | 2010-12-30 | Chinese herbal medicine extract preparation for preventing and treating mycoplasma gallisepticum and preparation method thereof |
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| CN102078550A true CN102078550A (en) | 2011-06-01 |
| CN102078550B CN102078550B (en) | 2012-11-21 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396514A (en) * | 2007-09-29 | 2009-04-01 | 张勇 | Traditional Chinese medicine formulation for treating Asia (Africa) chicken pest |
| CN101564479A (en) * | 2008-04-25 | 2009-10-28 | 张其权 | Traditional Chinese medicine for curing avian influenza and newcastle disease |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396514A (en) * | 2007-09-29 | 2009-04-01 | 张勇 | Traditional Chinese medicine formulation for treating Asia (Africa) chicken pest |
| CN101564479A (en) * | 2008-04-25 | 2009-10-28 | 张其权 | Traditional Chinese medicine for curing avian influenza and newcastle disease |
Non-Patent Citations (1)
| Title |
|---|
| 《动物医学进展》 19971110 岳治权 中药防治鸡传染性喉气管炎及支气管炎现状 第18卷, 第04期 2 * |
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Granted publication date: 20121121 Termination date: 20171230 |