CN102076681A - 作为治疗剂的取代γ-内酰胺 - Google Patents
作为治疗剂的取代γ-内酰胺 Download PDFInfo
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- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
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- 210000002445 nipple Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 208000008798 osteoma Diseases 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 208000001297 phlebitis Diseases 0.000 description 1
- 238000002428 photodynamic therapy Methods 0.000 description 1
- 229960002139 pilocarpine hydrochloride Drugs 0.000 description 1
- RNAICSBVACLLGM-GNAZCLTHSA-N pilocarpine hydrochloride Chemical compound Cl.C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C RNAICSBVACLLGM-GNAZCLTHSA-N 0.000 description 1
- 229960001963 pilocarpine nitrate Drugs 0.000 description 1
- 201000004849 posterior scleritis Diseases 0.000 description 1
- AEDNGGDZXGFKGS-UHFFFAOYSA-N potassium;trimethylsilylazanide Chemical class [K+].C[Si](C)(C)[NH-] AEDNGGDZXGFKGS-UHFFFAOYSA-N 0.000 description 1
- 229940094472 prenylamine lactate Drugs 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 201000007914 proliferative diabetic retinopathy Diseases 0.000 description 1
- 230000006785 proliferative vitreoretinopathy Effects 0.000 description 1
- 229940127293 prostanoid Drugs 0.000 description 1
- 150000003814 prostanoids Chemical class 0.000 description 1
- 201000007094 prostatitis Diseases 0.000 description 1
- 208000023558 pseudoxanthoma elasticum (inherited or acquired) Diseases 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- NRTYMEPCRDJMPZ-UHFFFAOYSA-N pyridine;2,2,2-trifluoroacetic acid Chemical compound C1=CC=NC=C1.OC(=O)C(F)(F)F NRTYMEPCRDJMPZ-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004258 retinal degeneration Effects 0.000 description 1
- 201000001184 retinal microaneurysm Diseases 0.000 description 1
- 239000000790 retinal pigment Substances 0.000 description 1
- 201000007714 retinoschisis Diseases 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
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- 229950004945 tibalosin Drugs 0.000 description 1
- 229960004605 timolol Drugs 0.000 description 1
- 229960000454 timolol hemihydrate Drugs 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 210000004127 vitreous body Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4750108P | 2008-04-24 | 2008-04-24 | |
| US61/047,501 | 2008-04-24 | ||
| PCT/US2009/041389 WO2009132088A1 (en) | 2008-04-24 | 2009-04-22 | Substituted gamma lactams as therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102076681A true CN102076681A (zh) | 2011-05-25 |
Family
ID=40852537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801242132A Pending CN102076681A (zh) | 2008-04-24 | 2009-04-22 | 作为治疗剂的取代γ-内酰胺 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7820661B2 (https=) |
| EP (1) | EP2291368B1 (https=) |
| JP (1) | JP5524181B2 (https=) |
| KR (1) | KR20110008263A (https=) |
| CN (1) | CN102076681A (https=) |
| AU (1) | AU2009239372B2 (https=) |
| BR (1) | BRPI0911347A2 (https=) |
| CA (1) | CA2722529A1 (https=) |
| CO (1) | CO6321273A2 (https=) |
| DK (1) | DK2291368T3 (https=) |
| ES (1) | ES2399314T3 (https=) |
| IL (1) | IL208899A0 (https=) |
| MX (1) | MX2010011636A (https=) |
| MY (1) | MY150518A (https=) |
| PL (1) | PL2291368T3 (https=) |
| RU (1) | RU2543379C2 (https=) |
| UA (1) | UA103616C2 (https=) |
| WO (1) | WO2009132088A1 (https=) |
| ZA (1) | ZA201007553B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107074832A (zh) * | 2014-10-02 | 2017-08-18 | 阿勒根公司 | γ‑内酰胺的酯前药及其用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9216183B2 (en) | 2002-02-04 | 2015-12-22 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US8758733B2 (en) | 2002-02-04 | 2014-06-24 | Allergan, Inc. | Topical treatment for chemotherapy induced eyelash loss or hypotrichosis using prostamide F2 alpha agonists |
| US7351404B2 (en) | 2002-02-04 | 2008-04-01 | Allergan, Inc. | Method of enhancing hair growth |
| EP1654002B2 (en) | 2003-08-07 | 2014-01-29 | Allergan, Inc. | Compositions for delivery of therapeutics into the eyes |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US8673341B2 (en) | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US8377984B2 (en) * | 2008-01-29 | 2013-02-19 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| US7842714B2 (en) * | 2008-03-03 | 2010-11-30 | Allergan, Inc. | Ketorolac tromethamine compositions for treating ocular pain |
| US9192571B2 (en) * | 2008-03-03 | 2015-11-24 | Allergan, Inc. | Ketorolac tromethamine compositions for treating or preventing ocular pain |
| US20110152328A1 (en) * | 2008-04-16 | 2011-06-23 | Whitcup Scott M | Combination Therapy For Glaucoma |
| JP2011518834A (ja) * | 2008-04-24 | 2011-06-30 | アラーガン インコーポレイテッド | 治療剤としての置換ガンマラクタム |
| EP2285775B1 (en) * | 2008-05-20 | 2017-03-22 | Allergan, Inc. | Lactams and their use in the treatment of inter alia ocular hypertension or baldness |
| US20100204335A1 (en) * | 2008-12-01 | 2010-08-12 | Allergan, Inc. | Kit and composition for eyelash growth |
| DK2498783T3 (en) | 2009-11-09 | 2018-12-10 | Allergan Inc | COMPOSITIONS AND PROCEDURES FOR STIMULATING HAIR GROWTH |
| US9149484B2 (en) | 2009-11-09 | 2015-10-06 | Allergan, Inc. | Compositions and methods for stimulating hair growth |
| US20110136872A1 (en) * | 2009-12-09 | 2011-06-09 | Burk Robert M | Stable aqueous compositions of prostglandin agonist prodrugs and methods for use thereof |
| AU2013306012B2 (en) * | 2012-08-21 | 2018-02-08 | Allergan, Inc. | Process for the synthesis of substituted gamma lactams |
| US9540357B1 (en) | 2014-07-31 | 2017-01-10 | Allergan, Inc. | 15-aryl prostaglandins as EP4 agonists, and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070219265A1 (en) * | 2006-03-20 | 2007-09-20 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| CN101137622A (zh) * | 2005-03-10 | 2008-03-05 | 阿勒根公司 | 作为治疗剂的取代的γ内酰胺 |
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| US3985798A (en) | 1975-01-27 | 1976-10-12 | American Cyanamid Company | 11α-HOMO-PROSTANOIC ACIDS AND ESTERS |
| US4060540A (en) | 1975-09-18 | 1977-11-29 | American Cyanamid Company | Novel 3-triphenylmethoxy-1-alkynes, 3-triphenyl-methoxy-1-trans-alkenyl-dialkyl-alanes, and lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates |
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2009
- 2009-04-22 UA UAA201013802A patent/UA103616C2/ru unknown
- 2009-04-22 JP JP2011506415A patent/JP5524181B2/ja not_active Expired - Fee Related
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- 2009-04-22 EP EP09734653A patent/EP2291368B1/en active Active
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- 2010-10-24 IL IL208899A patent/IL208899A0/en unknown
- 2010-11-22 CO CO10145796A patent/CO6321273A2/es active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101137622A (zh) * | 2005-03-10 | 2008-03-05 | 阿勒根公司 | 作为治疗剂的取代的γ内酰胺 |
| US20070219265A1 (en) * | 2006-03-20 | 2007-09-20 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107074832A (zh) * | 2014-10-02 | 2017-08-18 | 阿勒根公司 | γ‑内酰胺的酯前药及其用途 |
| CN107074832B (zh) * | 2014-10-02 | 2020-08-14 | 阿勒根公司 | γ-内酰胺的酯前药及其用途 |
| CN111978310A (zh) * | 2014-10-02 | 2020-11-24 | 阿勒根公司 | γ-内酰胺的酯前药及其用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009239372A1 (en) | 2009-10-29 |
| ZA201007553B (en) | 2011-08-31 |
| JP2011518833A (ja) | 2011-06-30 |
| MY150518A (en) | 2014-01-30 |
| MX2010011636A (es) | 2010-11-25 |
| US7820661B2 (en) | 2010-10-26 |
| EP2291368B1 (en) | 2012-12-19 |
| JP5524181B2 (ja) | 2014-06-18 |
| DK2291368T3 (da) | 2013-03-18 |
| US20090270392A1 (en) | 2009-10-29 |
| CO6321273A2 (es) | 2011-09-20 |
| AU2009239372B2 (en) | 2013-09-19 |
| IL208899A0 (en) | 2011-01-31 |
| EP2291368A1 (en) | 2011-03-09 |
| KR20110008263A (ko) | 2011-01-26 |
| UA103616C2 (ru) | 2013-11-11 |
| PL2291368T3 (pl) | 2013-05-31 |
| ES2399314T3 (es) | 2013-03-27 |
| RU2010144637A (ru) | 2012-05-27 |
| WO2009132088A1 (en) | 2009-10-29 |
| BRPI0911347A2 (pt) | 2018-03-20 |
| CA2722529A1 (en) | 2009-10-29 |
| RU2543379C2 (ru) | 2015-02-27 |
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Application publication date: 20110525 |