CN102076359A - 疫苗组合物和方法 - Google Patents

疫苗组合物和方法 Download PDF

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Publication number
CN102076359A
CN102076359A CN2009801254981A CN200980125498A CN102076359A CN 102076359 A CN102076359 A CN 102076359A CN 2009801254981 A CN2009801254981 A CN 2009801254981A CN 200980125498 A CN200980125498 A CN 200980125498A CN 102076359 A CN102076359 A CN 102076359A
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cell
antigens
compositions
activated
host
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迈克尔·哈-诺伊
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Immunovative Therapies Ltd
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Immunovative Therapies Ltd
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    • AHUMAN NECESSITIES
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K40/00Cellular immunotherapy
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    • A61K40/4262Heat shock proteins
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CN2009801254981A 2008-05-02 2009-05-04 疫苗组合物和方法 Pending CN102076359A (zh)

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US4999008P 2008-05-02 2008-05-02
US61/049,990 2008-05-02
US5029408P 2008-05-05 2008-05-05
US61/050,294 2008-05-05
PCT/US2009/042673 WO2009135199A2 (en) 2008-05-02 2009-05-04 Vaccine compositions and methods

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US (3) US20120128656A1 (enExample)
EP (1) EP2285405A4 (enExample)
JP (2) JP5709264B2 (enExample)
KR (1) KR101689210B1 (enExample)
CN (2) CN102076359A (enExample)
AU (1) AU2009242471B2 (enExample)
CA (1) CA2726007C (enExample)
IL (1) IL209027A (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103911341A (zh) * 2014-01-26 2014-07-09 山东迪博生物技术有限公司 Th1细胞亚群的制备方法及其在制备抗肿瘤细胞制剂中的应用
WO2015027915A1 (zh) * 2013-09-02 2015-03-05 北京中康万达医药科技有限公司 体内个体化系统免疫治疗方法和装置
CN104630145A (zh) * 2015-01-12 2015-05-20 杨世成 一种抗肿瘤t细胞、其制备方法和抗肿瘤药物
CN104830794A (zh) * 2015-05-05 2015-08-12 杨光华 基于hpve7抗原的dc细胞、靶向性免疫细胞群及其制备方法和用途
WO2025113111A1 (zh) * 2023-11-28 2025-06-05 苏州尔生生物医药有限公司 一种抗原组分的提取方法及包含其的递送粒子和应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110142887A1 (en) * 2009-12-15 2011-06-16 Immunovative Therapies Ltd. Methods and compositions for liquidation of tumors
KR102117350B1 (ko) * 2010-04-13 2020-06-02 이뮤노베이티브 테라피스, 엘티디. 조절 t 세포들의 저해를 위한 방법 및 조성물
BR112013028285A2 (pt) * 2011-05-03 2017-01-10 Immunovative Therapies Ltd indução de il-12 usando imunoterapia
US10272143B2 (en) 2014-01-08 2019-04-30 Immunovative Therapies Ltd. Treatment of human immunodeficiency virus/acquired immunodeficiency syndrome
AU2017233035B2 (en) * 2016-03-16 2021-08-05 Neximmune, Inc. Production of antigen-specific T-cells
KR20170127324A (ko) * 2016-05-11 2017-11-21 (주)제이티 반도체소자 캐리어, 이의 제조방법 및 이를 포함하는 소자핸들러
IL300809A (en) * 2020-09-02 2023-04-01 Yztherapeutic Performance Ltd Cellular preparation for the treatment of diseases and method of use
CA3243354A1 (en) * 2022-02-03 2023-08-10 Microvax Llc A mRNA VACCINE DESIGN USING MULTIPLE INTERACTING IMMUNO-STIMULATORY PATHWAYS, FOR CANCER AND INFECTIOUS DISEASES
US20250319132A1 (en) * 2024-04-16 2025-10-16 Mirror Biologics, Inc. Methods and compositions for improving the immune response against viral pathogens

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040228848A1 (en) * 2003-05-13 2004-11-18 Michael Har-Noy Allogeneic cell therapy: mirror effect
WO2007120128A1 (en) * 2006-04-13 2007-10-25 Immunovative Therapies, Ltd. Allogeneic cell therapy for treatment of opportunistic infection

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747024A (en) * 1993-03-08 1998-05-05 Immunex Corporation Vaccine adjuvant comprising interleukin-15
US5837251A (en) 1995-09-13 1998-11-17 Fordham University Compositions and methods using complexes of heat shock proteins and antigenic molecules for the treatment and prevention of neoplastic diseases
US6797480B1 (en) 1998-10-05 2004-09-28 University Of Connecticut Health Center Purification of heat shock/stress protein cell surface receptors and their use as immunotherapeutic agents
US6875849B2 (en) * 2001-05-01 2005-04-05 Arizona Board Of Regents Of Behalf Of The University Of Arizona Methods of recovering chaperone proteins and complexes thereof
US20030134415A1 (en) * 2001-09-19 2003-07-17 Gruenberg Micheal L. Th1 cell adoptive immunotherapy
US20040202663A1 (en) * 2003-01-28 2004-10-14 Shanghai Sunway Biotech Co., Ltd. Therapy for primary and metastatic cancers
US7402431B2 (en) 2004-03-01 2008-07-22 Immunovative Therapies, Ltd. T-cell therapy formulation
US7678572B2 (en) 2004-02-26 2010-03-16 Immunovative Therapies, Ltd. Methods for preparing T-cells for cell therapy
EP1896570A2 (en) * 2005-05-10 2008-03-12 Avaris AB Cellular vaccine and use thereof
US7553661B2 (en) * 2005-05-31 2009-06-30 Mcgill University Stromal antigen-presenting cells and use thereof
EP2091334A4 (en) * 2006-10-31 2010-02-03 Hasumi Internat Res Foundation TUMOR TREATMENT BY INJECTION OF DENDRITIC CELLS AND CORRESPONDING VACCINE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040228848A1 (en) * 2003-05-13 2004-11-18 Michael Har-Noy Allogeneic cell therapy: mirror effect
WO2007120128A1 (en) * 2006-04-13 2007-10-25 Immunovative Therapies, Ltd. Allogeneic cell therapy for treatment of opportunistic infection

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HAR-NOY M. ET AL.: "The anti-tumor effect of allogeneic bone marrow/stem cell transplant without graft vs. host disease toxicity and without a matched donor requirement?", 《MEDICAL HYPOTHESES》 *
WOODLAND DAVID L.: "Jump-starting the immune system: prime–boosting comes of age", 《TRENDS IN IMMUNOLOGY》 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015027915A1 (zh) * 2013-09-02 2015-03-05 北京中康万达医药科技有限公司 体内个体化系统免疫治疗方法和装置
US10980859B2 (en) 2013-09-02 2021-04-20 Hangzhou Converd Co., Ltd. In vivo individualized systemic immunotherapeutic method and device
CN103911341A (zh) * 2014-01-26 2014-07-09 山东迪博生物技术有限公司 Th1细胞亚群的制备方法及其在制备抗肿瘤细胞制剂中的应用
CN103911341B (zh) * 2014-01-26 2016-04-13 山东迪博生物科技股份有限公司 Th1细胞亚群的制备方法及其在制备抗肿瘤细胞制剂中的应用
CN104630145A (zh) * 2015-01-12 2015-05-20 杨世成 一种抗肿瘤t细胞、其制备方法和抗肿瘤药物
CN104830794A (zh) * 2015-05-05 2015-08-12 杨光华 基于hpve7抗原的dc细胞、靶向性免疫细胞群及其制备方法和用途
WO2025113111A1 (zh) * 2023-11-28 2025-06-05 苏州尔生生物医药有限公司 一种抗原组分的提取方法及包含其的递送粒子和应用

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AU2009242471A1 (en) 2009-11-05
JP2014098035A (ja) 2014-05-29
AU2009242471B2 (en) 2015-06-11
CA2726007A1 (en) 2009-11-05
CA2726007C (en) 2019-04-09
WO2009135199A2 (en) 2009-11-05
US20200261509A1 (en) 2020-08-20
US20120128656A1 (en) 2012-05-24
CN108743937B (zh) 2022-08-30
JP5709264B2 (ja) 2015-04-30
EP2285405A4 (en) 2012-09-19
KR20110002496A (ko) 2011-01-07
IL209027A0 (en) 2011-01-31
IL209027A (en) 2017-11-30
US20190105350A1 (en) 2019-04-11
EP2285405A2 (en) 2011-02-23
KR101689210B1 (ko) 2016-12-23
US12233091B2 (en) 2025-02-25
WO2009135199A3 (en) 2010-03-04
CN108743937A (zh) 2018-11-06
US10751372B2 (en) 2020-08-25
JP2011519869A (ja) 2011-07-14

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