CN102068610A - Traditional Chinese medicine composition with moisturizing effect, preparation and preparation method thereof - Google Patents
Traditional Chinese medicine composition with moisturizing effect, preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition with the moisturizing effect, which is prepared by the following active pharmaceutical ingredients in parts by weight: 10-20 parts of fragrant solomonseal rhizome, 10-20 parts of rhizome, 5-10 parts of dwarf lilyturf tuber and 10-15 parts of liquoric root. An active extract obtained by extraction from the composition with the moisturizing effect has strong capability of inhibiting water loss on the surface of skin, that is the barrier function of the surface of the skin is enhanced, the active extract has stronger moisturizing capability, and experiments prove that the traditional Chinese medicine composition has the moisturizing effect which is obviously better than that of a moisturizing product on the market, and can obviously increase the glossiness of the skin after being used for 30 days and enable the skin to be fine and mellow. The traditional Chinese medicine composition is simple to acquire the active ingredients, and can be prepared into different formulations, the preparation method is convenient and fast, and the traditional Chinese medicine composition is easy to be accepted by the vast number of consumers and has good application and market prospects.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, specifically a kind of Chinese medicine topical composition that can effectively play the moisturizing effect, and by external preparation of said composition preparation and preparation method thereof.
Background technology
Along with the raising of people's living standard and people to the safety of cosmetics and the raising of effect understanding, preserving moisture is that the skin Eternal Theme is supported in skin protection, preserving moisture is the basis that all cosmetics are brought into play other effects.
The class cosmetics of preserving moisture of Xiao Shouing are of a great variety in the market, and moistening effect is not obvious and moisture preserving time short, and preserving moisture is not the ubiquitous problem in commercially available prod lastingly.
Those skilled in the art have done a lot of improvement in order to address the above problem to main dosage form, and have in some skin care item and add Chinese medicine, to strengthen the moistening effect of skin care item.But the Chinese medicine skin care item have a lot of defectives, as the general ion concentration height of Chinese medicine, the smell is awful, inconvenience preparation, to merge performance bad etc. with existing skin care item batching.Because the existence of these defectives, can only add simply in the general Chinese medicine skin care item or two flavor Chinese medicines use as additive, and measure for a short time, can't carry out reasonable compatibility according to Chinese medicine pharmacy principle, most importantly these Chinese medicine additive are many to increase water content and oil, are main purpose with the moisturizing.Though can increase moistening effect but use like this, endurance still can not get a promotion.
Because above-mentioned defective has not only suppressed the development of Chinese medicine skin care item, and can't bring into play the application of numerous Chinese crude drugs in skin care field.
Summary of the invention
The purpose of this invention is to provide a kind of moisturizing skin effect of having, be used for the Chinese medicine composition of daily preserving moisture and protecting skin or preparation preserving moisture and protecting skin product usefulness.
Another object of the present invention is to propose a kind of preparation method of above-mentioned Chinese medicine composition.
A further object of the present invention is to propose to utilize the skin care formulation of above-mentioned Chinese medicine composition preparation.
The present invention selects Rhizoma Polygonati Odorati, Rhizoma Polygonati, Radix Ophiopogonis and the combination of Radix Glycyrrhizae four Chinese medicine thing for use, thereby effectively plays moisture-keeping efficacy.The brief introduction of four Chinese medicine thing medical material effect is as follows:
Rhizoma Polygonati Odorati: have the laboratory animal of promotion antibody and generate, that improves macrophage engulfs percent and phagocytic index, promotes interferon synthetic, suppresses growth of bacillus tubercle, blood sugar lowering, blood fat reducing is alleviated atherosclerotic plaque and is formed, and makes peripheral blood vessel and coronary dilation, prolong hypoxia endurance time, heart tonifying, antioxidation, the anti-ageing effect of waiting for a long time.Also has the effect of similar adrenocortical hormone sample.
Rhizoma Polygonati: the root stock of Rhizoma Polygonati contains steroid saponin, has isolated 2 furan steroid enol form Saponins and 2 spirostene alcohol type Saponins.Rhizoma Polygonati has the effect of resisting fatigue, antioxidation and slow down aging.
Radix Ophiopogonis: have the replenishing YIN and removing heat effect, can treat that cough, expectorant due to interior-heat caused by deficiency of YIN or consumption of body fluid caused by febrile disease, restlessness and thirst, the dryness-heat impairing the lung is thick, QI rising in reverse order etc.
Radix Glycyrrhizae: Radix Glycyrrhizae property is flat, and sweet in the mouth is returned 12 warps.Detoxifcation arranged, eliminate the phlegm, pain relieving, spasmolytic be so that pharmacological action such as anticancer.On the traditional Chinese medical science, the Radix Glycyrrhizae invigorating the spleen and replenishing QI is grown and to be coughed lung moistening, and the emergency detoxifcation is in harmonious proportion hundred medicines.
The present inventor carries out above-mentioned four Chinese medicine thing compatibility and finds out best proportioning consumption.Rhizoma Polygonati Odorati has the effect that YIN nourishing and the production of body fluid promoting is moisturized; But Rhizoma Polygonati YIN nourishing, QI invigorating; Radix Ophiopogonis, YIN nourishing and the production of body fluid promoting cooperated the Radix Glycyrrhizae benefiting vital QI and blood, coordinating the actions of various ingredients in a prescription.Produce synergism between each component in the Chinese medicine composition of the present invention, in moisturizing, suppress the skin surface moisture loss, strengthen the skin surface barrier action, thereby play the effect of efficient moisture-retention, have no side effect skin is non-stimulated.
Concrete technical scheme of the present invention is as follows:
A kind of Chinese medicine composition with moisturizing effect, described compositions are mainly made by following raw materials in weight portion medicine:
10～20 parts of Rhizoma Polygonati Odorati, 10～20 parts of Rhizoma Polygonatis, 5～10 parts of Radix Ophiopogonis, 10～15 parts in Radix Glycyrrhizae.
Weight portion proportioning preferable between each crude drug of described compositions is:
12～20 parts of Rhizoma Polygonati Odorati, 12～18 parts of Rhizoma Polygonatis, 5～8 parts of Radix Ophiopogonis, 10～15 parts in Radix Glycyrrhizae.
Weight portion proportioning best between each crude drug of described compositions is:
20 parts of Rhizoma Polygonati Odorati, 15 parts of Rhizoma Polygonatis, 5 parts of Radix Ophiopogonis, 10 parts in Radix Glycyrrhizae.
A kind of method for preparing above-mentioned Chinese medicine composition, concrete steps are as follows:
(1) takes by weighing each crude drug according to said components and consumption;
(2) mixed being incorporated in the water of each crude drug soaked, soak time is more than 2 hours; (addition of water was as the criterion to flood crude drug)
(3) crude drug after step (2) is soaked adds water and mixes and stir, and boils from liquid constantly to pick up counting, and boils 1～3 hour, and the mass volume ratio of described crude drug and water (g/ml) is 0.5～1: 10～20;
(4) stop heating, carry out second extraction after being cooled to 30～55 ℃ of filtrations, the mass volume ratio of filtration residue and water (g/ml) is 0.5～1: 10～20, boils 1～3 hour;
(5) be cooled to 30～55 ℃ of filtrations after, the filtrate of collecting step (3) and step (4) extracted twice carries out vacuum filtration, promptly obtains activity extract.
Preferred 1: 10 of the mass volume ratio (g/ml) of filtration residue and water described in preferred 1: 20 of the mass volume ratio of crude drug and water described in the described step (3) and/or the step (4).
Filter in described step (4) and/or the step (5) is that 100～200 orders filter preferred 200 orders.
Vacuum filtration is to utilize kieselguhr or fine straining plate to filter in the described step (5), and fineness is 500～700 orders, and vacuum is 0.05～0.1MPa.
Described water can use deionized water, distilled water or pure water.
A kind of activity extract with moisturizing effect, described extract are to prepare through above-mentioned method.
The application of above-mentioned activity extract in the preparation skin care formulation.
A kind of skin care product additive with moisturizing effect, make by following raw materials in weight portion medicine:
95～100 parts of above-mentioned activity extracts, 8～12 parts of glycerol, 3～5 parts of trehaloses.
A kind of skin care formulation with moisturizing effect, described preparation is made up of above-mentioned activity extract and skin care field acceptable auxiliary.According to use approach difference, the present composition is made external preparation, as external facial cream, emulsion, cosmetic water, cleansing milk, spray or essence.But be not limited to above-mentioned dosage form, can be according to known method in the skin care item industrial circle, make various external preparation after aforementioned pharmaceutical compositions extracted degerming by known method.
The preparation of preserving moisture that the present invention makes.Its usage and consumption are as follows:
Method: after clean of every day, smear the present invention's preparation of preserving moisture on skin, each is once sooner or later.
Consumption: determine according to individual demand, smear preparation of the present invention in right amount and get final product.For drying or sensitive part, can smear repeatedly, be as the criterion with whole coverings.
Beneficial effect of the present invention:
The present invention preserves moisture, and to suppress skin surface moisture loss ability strong for extract and the preparation of preserving moisture, promptly strengthened the barrier function of skin surface, has stronger moisture-retaining capacity, experimental results show that the present invention has the moistening effect of the series products that obviously is better than preserving moisture on the market, use the glossiness that can also obviously increase skin after 30 days, the skin exquisiteness is mellow and full.Raw material of the present invention obtains simply, can be prepared into different dosage form, and preparation method is convenient, and the low effect of cost is fine, is easy to be accepted by consumers in general, has good application prospects and market prospect.
Foregoing invention content part of the present invention has been done detailed description to technical scheme of the present invention, and those skilled in the art can repeat the present invention and obtain technique effect of the present invention according to foregoing.Below by the specific embodiment the technology of the present invention content being further explained, understanding content of the present invention so that those skilled in the art are clearer, is not limitation of the present invention, and any being equal to replaces or known change all belongs to protection domain of the present invention.
Description of drawings
Describe the specific embodiment of the present invention in detail below in conjunction with accompanying drawing:
Fig. 1 is the skin hydration rate figure of Chinese medicine extract;
Fig. 2 is the percutaneous moisture loss rate figure of Chinese medicine extract.
The specific embodiment
The used medical material of present embodiment all can be bought from China Medicament Group Corp. and obtain, and meets 2005 editions standards of Pharmacopoeia of People's Republic of China.Other compositions are the conventional adjuvant of skin care item and cosmetic field, all can obtain by commercially available purchase.Glycerol and trehalose are known commercially available prod, available from the many fragrant bio tech ltds of Beijing China.Kieselguhr is available from chemical reagents corporation of traditional Chinese medicines group, model: chemical pure 91053-39.
The preparation of embodiment 1 activity extract of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Rhizoma Polygonati Odorati 20g, Rhizoma Polygonati 15g, Radix Ophiopogonis 5g, Radix Glycyrrhizae 10g.
(2) mixed being incorporated in the deionized water of each crude drug soaked, soak time is 2 hours;
(3) crude drug after step (2) is soaked adds deionized water and mixes and stir, and boils from liquid constantly to pick up counting, and boils 1 hour, and the mass volume ratio of described crude drug and deionized water is 1: 20, promptly adds the 1000ml deionized water;
(4) stop heating, be cooled to 30 ℃, 200 orders carry out second extraction after filtering, and the mass volume ratio of filtration residue and deionized water (g/ml) is 1: 10, boils 1 hour;
(5) be cooled to 30 ℃, after 200 orders filter, collect the filtrate of step (3) and step (4) extracted twice, carry out the kieselguhr vacuum filtration, fineness is 500 orders, and vacuum is 0.05～0.1MPa, and vacuum has a little floating from more to less according to sucking filtration liquid, as long as be controlled in this scope, finally prepare activity extract.
Measure electrical conductivity, pH value, solid content, total sugar content, measurement result is: electrical conductivity is that 1000～1300 μ s/cm, pH are 3.0～5.0, solid content is 12～15%, total sugar content is 40～80mg/mL;
Sterilization afterwards adds 0.6%L.GP, obtains product; This antiseptic full name is LIQUID GERMALLPLUS, available from the international special product company limited of ISP.Also can carry out subsequent operation as required.
The preparation of embodiment 2 activity extracts of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Rhizoma Polygonati Odorati 10g, Rhizoma Polygonati 10g, Radix Ophiopogonis 10g, Radix Glycyrrhizae 15g.
(2) mixed being incorporated in the deionized water of each crude drug soaked, soak time is 4 hours;
(3) crude drug after step (2) is soaked adds deionized water and mixes and stir, and boils from liquid constantly to pick up counting, and boils 2 hours, and the mass volume ratio of described crude drug and deionized water (g/ml) is 0.5: 10, promptly adds the 900ml deionized water;
(4) stop heating, be cooled to 55 ℃, 100 orders carry out second extraction after filtering, and the mass volume ratio of filtration residue and deionized water (g/ml) is 1: 5, boils 2 hours;
(5) be cooled to 55 ℃, after 100 orders filter, collect the filtrate of step (3) and step (4) extracted twice, carry out the kieselguhr vacuum filtration, fineness is 600 orders, and vacuum is 0.05～0.1MPa, and vacuum has a little floating from more to less according to sucking filtration liquid, as long as be controlled in this scope, finally prepare activity extract.
Measure electrical conductivity, pH value, solid content, total sugar content, measurement result is: electrical conductivity is that 1000～1150 μ s/cm, pH are 3.0～5.0, solid content is 13～15%, total sugar content is 60～80mg/mL.
The preparation of embodiment 3 skin protection additives of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Rhizoma Polygonati Odorati 12g, Rhizoma Polygonati 20g, Radix Ophiopogonis 6g, Radix Glycyrrhizae 12g.
(2) mixed being incorporated in the distilled water of each crude drug soaked, soak time is 6 hours;
(3) the crude drug adding distil water after step (2) is soaked mixes and stirs, and boils from liquid constantly to pick up counting, and boils 3 hours, and the mass volume ratio of described crude drug and distilled water (g/ml) is 0.5: 15, promptly adds the 1500ml distilled water;
(4) stop heating, be cooled to 45 ℃, 200 orders carry out second extraction after filtering, and the mass volume ratio of filtration residue and distilled water (g/ml) is 1: 15, boils 3 hours;
(5) be cooled to 45 ℃, after 200 orders filter, collect the filtrate of step (3) and step (4) extracted twice, carry out the kieselguhr vacuum filtration, fineness is 700 orders, and vacuum is 0.05～0.1MPa, and vacuum has a little floating from more to less according to sucking filtration liquid, as long as be controlled in this scope, finally prepare activity extract;
(6) add glycerol and trehalose, described activity extract: glycerol: the mass ratio of trehalose is 100: 10: 5.
Measure electrical conductivity, pH value, solid content, total sugar content, measurement result is: electrical conductivity is that 1000～1500 μ s/cm, pH are 3.0～5.0, solid content is 12～15%, total sugar content is 40～75mg/mL;
Sterilization afterwards adds 0.6%L.GP, obtains product; This antiseptic full name is LIQUID GERMALLPLUS, available from the international special product company limited of ISP.
The preparation of embodiment 4 skin protection additives of the present invention
(1) take by weighing each crude drug according to following component and consumption:
Rhizoma Polygonati Odorati 18g, Rhizoma Polygonati 18g, Radix Ophiopogonis 8g, Radix Glycyrrhizae 10g.
(2) mixed being incorporated in the deionized water of each crude drug soaked, soak time is 12 hours;
(3) crude drug after step (2) is soaked adds deionized water and mixes and stir, and boils from liquid constantly to pick up counting, and boils 2 hours, and the mass volume ratio of described crude drug and deionized water (g/ml) is 0.5: 20, promptly adds the 2160ml deionized water;
(4) stop heating, be cooled to 45 ℃, 200 orders carry out second extraction after filtering, and the mass volume ratio of filtration residue and deionized water (g/ml) is 0.5: 20, boils 2 hours;
(5) be cooled to 45 ℃, after 200 orders filter, collect the filtrate of step (3) and step (4) extracted twice, carry out fine straining plate vacuum filtration, fineness is 500 orders, and vacuum is 0.05～0.1MPa, and vacuum has a little floating from more to less according to sucking filtration liquid, as long as be controlled in this scope, finally prepare activity extract;
(6) add glycerol and trehalose, described activity extract: glycerol: the mass ratio of trehalose is 95: 8: 3.
Measure electrical conductivity, pH value, solid content, total sugar content, measurement result is: electrical conductivity is that 1000～1500 μ s/cm, pH are 3.0～5.0, solid content is 13～15%, total sugar content is 45～90mg/mL;
Sterilization afterwards adds 0.6%L.GP, obtains product; This antiseptic full name is LIQUID GERMALLPLUS, available from the international special product company limited of ISP.
The preparation of embodiment 5 facial creams of the present invention
Component A: Cera Flava 5g, stearic acid 1g, white oil 2g, vitamin E 3g
Activity extract 30g, distilled water 56.4g, the chitosan 2g of B component: embodiment 4 preparations;
Component C: vitamin C 0.15g, essence 0.25g, antiseptic 0.2g
Concrete preparation method: component A is mixed and heated to 75 ℃; The B group is mixed and heated to 75 ℃; Under 45 rev/mins of mixing speeds, component A is joined in the B component evenly, carry out emulsifying.Add the C group when cooling the temperature to 50 ℃, stir, finished product is promptly made in packing.
The preparation of embodiment 6 sprays of the present invention
Raw material:
Vitamin E: 10g
Chitosan: 0.5g
Deionized water 30g
Glycerol 5g
Adjuvant: the third butagas 34.5g.(also can select tetrafluoroethane or Difluoroethane)
Concrete preparation method:
(1) with vitamin E, chitosan, activity extract, deionized water mix homogeneously, 75 ℃ following 45 rev/mins were stirred 20 minutes in agitated kettle;
(2) be cooled to 50 ℃ and stir after adding the glycerol mix homogeneously, 45 rev/mins of mixing speeds, 50 ℃ of temperature, the skin care item active component is finished in i.e. preparation after 20 minutes;
(3) add third butagas in the time of with the active component fill; Promptly be prepared into the spray of preserving moisture of the present invention.
Efficacy test of the present invention and clinical experiment
1, keratodermatitis hydration rate test
This method of testing is carried out according to the method that following document provides: Zhao Hua, Dong Yinmao, He Congfen, Lan Sheyi, Wang Changtao, the foundation of cosmetic industry evaluation methodology, Beijing daily use chemicals, 2006 the 4th phases, 20-23.
The mensuration of keratodermatitis moisture: its operation principle is to be instrument probe with the capacitor, because water is the material of dielectric constant maximum on the skin, when skin moisture content changes, the capacitance of skin also changes, so can be by measuring skin capacitance, analyzing skin surface moisture content.Instrument commonly used is Corneometer CM825.Weigh the variation of horny layer water content by measuring the variation of using product front and back keratodermatitis capacitance, thereby this kind of moisture-keeping efficacy method of estimating cosmetics is carried out quantification to the moisture of keratodermatitis, can react the variation of skin moisture content delicately, and favorable reproducibility is one of present moisture-keeping cosmetics effect evaluation method commonly used.
Experimental technique: bend side at candidate left and right sides forearm and mark 3 * 3cm
2The square Experimental Area of size, with the test zone of left arm as moisturizer, the corresponding symmetrical region of right arm is a blank, detects the moisture at each test position then with Corneometer CM825 tester, repeats respectively 5 times, draws meansigma methods.With formula (1) calculated hydration rate.
Experimental result is seen Fig. 1.As shown in Figure 1, the arm skin of the extract of embodiment 1 preparation of smearing illustrates that obviously than the hydration rate height of blank value Chinese medicine extract provided by the invention has very strong moisture-keeping efficacy.
2, horny layer moisture loss test
This method is carried out according to the method that following document provides: Zhao Hua, Dong Yinmao, He Congfen, Lan Sheyi, Wang Changtao, the foundation of cosmetic industry evaluation methodology, Beijing daily use chemicals, 2006 the 4th phases, 20-23.
The assay method of moisture percutaneous lost (Transepidermal water loss is called for short TEWL): test philosophy is to close on the variation that the skin surface moisture vapor is pressed according to the diffusion principle measurement that A.Fick found in 1885.Use the circular cylindrical cavity measuring probe of the both ends open of particular design to form metastable test subenvironment at skin surface, by two groups of temperature, the nearly epidermis of humidity sensor measuring (in about 1cm) by the horny layer moisture loss form different 2 water vapor pressure gradient, directly measure through epidermis moisture evaporated amount, weigh skin surface water loss situation with this, thereby can estimate the moisture-keeping efficacy of cosmetics at skin surface.The TEWL value is an important symbol of skin barrier quality, and the TEWL value of skin is low more, illustrates that the barrier function of skin is just good more, otherwise then poor more.Moisture of skin loss tester (TEWL) (Tewameter product type: TM300) come the barrier function of evaluating skin, and then estimate the moistening effect of cosmetics to moisture from skin surface water loss rate.
Experimental technique: measure moisture with Tewameter TM300 moisture of skin loss tester and scatter and disappear through skin.Not direct representation of the TEWL horny layer water yield, it reflects cuticular barrier function, is the important factor of estimating the horny layer state.Calculate percutaneous moisture loss rate with formula (2).
This experimental result as shown in Figure 2, as shown in Figure 2, the additive of embodiment 3 preparation suppresses the very capable of tested skin surface moisture loss, has promptly strengthened the barrier function of skin surface.Prove that product provided by the invention has stronger moisture-retaining capacity, can use separately also to can be used for preparing cosmetics, especially be used for preparing cosmetic with moisture-keeping efficacy.
3, clinical experiment example of the present invention
The experiment grouping: select age bracket at 15 years old to 60 years old volunteer, all do not have the skin medical history, 20 of male volunteers, 20 of women volunteers are divided into four groups at random, every group 10 people.
Experimental technique: group 1: after clean of every day, it is an amount of to apply the embodiment of the invention 5 preparation facial creams on facial skin, and each is once sooner or later.Group 2: after clean of every day, it is an amount of to spray the embodiment of the invention 6 preparation sprays on facial skin, and each is once sooner or later.Group 3: after clean of every day, the spray that sprays embodiment 6 preparations on facial skin earlier is an amount of, and then it is an amount of to apply the embodiment of the invention 5 preparation facial creams, and each is once sooner or later.Group 4 (matched groups): it is an amount of to smear commercially available certain preparation of preserving moisture after clean of every day, and each is once sooner or later.
3 days, 7 days, 1 month, 3 months each statistics once.
Evaluation criterion: measure by Beijing Technology and Business University effect evaluation experimental chamber, measure skin moisture content and moisture content and scatter and disappear, skin moisture content increases, and illustrates that moistening effect is good.Moisture of skin scatters and disappears the skin moisture-keeping weak effect is described greatly.Determine the moistening effect of product.
Experimental result: this product has the moistening effect of the series products that obviously is better than preserving moisture on the market, uses the glossiness that can also obviously increase skin after 30 days, and the skin exquisiteness is mellow and full.
Estimate by the moistening effect effect, group 1 is by smearing the facial cream of the embodiment of the invention 5 preparations, and skin moisture content increases by 40%, and the moisture of skin scatter ratio, scatter and disappear ratio reduces 50%; Organizing 2 experimenter's moistures increases by 40%, and the moisture of skin scatter ratio, scatter and disappear ratio reduces 50%; Organizing 3 experimenter's moistures increases by 45%, and the moisture of skin scatter ratio, scatter and disappear ratio reduces 55%; Each group is by comparing with matched group, and moistening effect is better lasting, and moistening effect reached more than 8 hours, and the commercially available prod moistening effect is 4 hours.Matched group makes skin moisture content increase by 30%, makes the moisture of skin scatter ratio, scatter and disappear ratio reduce 35%.From moistening effect and moisture preserving time, the present invention is much better than the commercially available prod.And preparation of the present invention does not have an example reaction phenomenons such as allergy, skin discomfort to occur.
Claims (10)
1. the Chinese medicine composition with moisturizing effect is characterized in that, described compositions is made by following raw materials in weight portion medicine:
10～20 parts of Rhizoma Polygonati Odorati, 10～20 parts of Rhizoma Polygonatis, 5～10 parts of Radix Ophiopogonis, 10～15 parts in Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1 is characterized in that, described compositions is made by following raw materials in weight portion medicine:
12～20 parts of Rhizoma Polygonati Odorati, 12～18 parts of Rhizoma Polygonatis, 5～8 parts of Radix Ophiopogonis, 10～15 parts in Radix Glycyrrhizae.
3. Chinese medicine composition according to claim 2 is characterized in that, described compositions is made by following raw materials in weight portion medicine:
20 parts of Rhizoma Polygonati Odorati, 15 parts of Rhizoma Polygonatis, 5 parts of Radix Ophiopogonis, 10 parts in Radix Glycyrrhizae.
4. method for preparing claim 1,2 or 3 described Chinese medicine compositions is characterized in that concrete steps are as follows:
(1) takes by weighing each crude drug according to claim 1,2 or 3 described components and consumption;
(2) mixed being incorporated in the water of each crude drug soaked, soak time is more than 2 hours;
(3) crude drug after step (2) is soaked adds water and mixes and stir, and boils from liquid constantly to pick up counting, and boils 1～3 hour, and the mass volume ratio g/ml of described crude drug and water is 0.5～1: 10～20;
(4) stop heating, carry out second extraction after being cooled to 30～55 ℃ of filtrations, the mass volume ratio g/ml of described filtration residue and water is 0.5～1: 10～20, boils 1～3 hour;
(5) be cooled to 30～55 ℃ of filtrations after, the filtrate of collecting step (3) and step (4) extracted twice carries out vacuum filtration, promptly obtains activity extract.
5. method according to claim 4 is characterized in that, filtering in described step (4) and/or the step (5) is that 100～200 orders filter.
6. method according to claim 5 is characterized in that, the mass volume ratio of crude drug and water described in the described step (3) is that the mass volume ratio g/ml of filtration residue described in 1: 20 and/or the step (4) and water is 1: 10.
7. method according to claim 6 is characterized in that, the fineness of vacuum filtration is 500～700 orders in the described step (5), and vacuum is 0.05～0.1MPa.
8. the activity extract with moisturizing effect is characterized in that, described extract prepares through claim 4,5,6 or 7 described methods.
9. the application of the described activity extract of claim 8 in the preparation skin care formulation.
10. the skin care product additive with moisturizing effect is characterized in that, is made by following raw materials in weight portion medicine:
95～100 parts of the described activity extracts of claim 8,8～12 parts of glycerol, 3～5 parts of trehaloses.
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| WO2012146169A1 (en) * | 2011-04-26 | 2012-11-01 | 上海家化联合股份有限公司 | Chinese herbal extract, preparing method and application thereof |
| CN104012970A (en) * | 2014-06-16 | 2014-09-03 | 济南科纳信息科技有限公司 | Sealwort ultrafine powder chewable tablets and preparation method thereof |
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| CN105031239B (en) * | 2015-07-10 | 2018-06-22 | 北京国济众芳中医药研究所 | There is external medicine composition, preparation of scalp moisturization strengthen the hair and preparation method thereof |
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| CN108524429A (en) * | 2018-06-29 | 2018-09-14 | 韩彩敏 | A kind of replenishing water and preserving moisture facial mask |
| CN109221713A (en) * | 2018-10-10 | 2019-01-18 | 宝鸡神农农业科技有限公司 | Herd boar extruding establishing-Yang pannage and preparation method thereof |
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