CN113876669B - Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product - Google Patents
Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product Download PDFInfo
- Publication number
- CN113876669B CN113876669B CN202111357752.XA CN202111357752A CN113876669B CN 113876669 B CN113876669 B CN 113876669B CN 202111357752 A CN202111357752 A CN 202111357752A CN 113876669 B CN113876669 B CN 113876669B
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- composition
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 239000003814 drug Substances 0.000 title claims abstract description 35
- 239000002537 cosmetic Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 239000000284 extract Substances 0.000 claims abstract description 59
- 244000042430 Rhodiola rosea Species 0.000 claims abstract description 34
- 235000003713 Rhodiola rosea Nutrition 0.000 claims abstract description 34
- 235000020691 dandelion extract Nutrition 0.000 claims abstract description 31
- 229940067866 dandelion extract Drugs 0.000 claims abstract description 30
- 239000001845 taraxacum officinale leaf extract Substances 0.000 claims abstract description 30
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 12
- 239000006071 cream Substances 0.000 claims abstract description 10
- 230000002195 synergetic effect Effects 0.000 claims abstract description 8
- 230000000694 effects Effects 0.000 claims description 32
- 108010005094 Advanced Glycation End Products Proteins 0.000 claims description 20
- 239000000047 product Substances 0.000 claims description 18
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- -1 polyoxyethylene Polymers 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 5
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 2
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- 229960000458 allantoin Drugs 0.000 claims description 2
- 229960001631 carbomer Drugs 0.000 claims description 2
- 239000008367 deionised water Substances 0.000 claims description 2
- 229910021641 deionized water Inorganic materials 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 229960002216 methylparaben Drugs 0.000 claims description 2
- 239000002480 mineral oil Substances 0.000 claims description 2
- 235000010446 mineral oil Nutrition 0.000 claims description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- CKQVRZJOMJRTOY-UHFFFAOYSA-N octadecanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCC(O)=O CKQVRZJOMJRTOY-UHFFFAOYSA-N 0.000 claims description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 229960003415 propylparaben Drugs 0.000 claims description 2
- 229940032094 squalane Drugs 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract description 6
- 230000003013 cytotoxicity Effects 0.000 abstract description 6
- 230000013595 glycosylation Effects 0.000 abstract description 5
- 239000008406 cosmetic ingredient Substances 0.000 abstract description 4
- 238000010876 biochemical test Methods 0.000 abstract 1
- 238000002156 mixing Methods 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 8
- 229930014626 natural product Natural products 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 238000006206 glycosylation reaction Methods 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 230000003796 beauty Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 241000411851 herbal medicine Species 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 241000245665 Taraxacum Species 0.000 description 3
- 241000292546 Taraxacum mongolicum Species 0.000 description 3
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 150000008442 polyphenolic compounds Chemical class 0.000 description 3
- 235000013824 polyphenols Nutrition 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 2
- 108091005461 Nucleic proteins Proteins 0.000 description 2
- 108010087230 Sincalide Proteins 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 238000010609 cell counting kit-8 assay Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229930003658 monoterpene Natural products 0.000 description 2
- 235000002577 monoterpenes Nutrition 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- XWMMEBCFHUKHEX-MRTCRTFGSA-N (+)-Taraxasterol Chemical compound C([C@@]12C)C[C@H](O)C(C)(C)[C@@H]1CC[C@]1(C)[C@@H]2CC[C@H]2[C@@H]3[C@H](C)C(=C)CC[C@]3(C)CC[C@]21C XWMMEBCFHUKHEX-MRTCRTFGSA-N 0.000 description 1
- QMKPCZNFLUQTJZ-UHFFFAOYSA-N (4aR)-10c-Hydroxy-1t.2c.4ar.6at.6bc.9.9.12ac-octamethyl-(8atH.12btH.14acH.14btH)-docosahydro-picen Natural products CC1CCC2(C)CCC3(C)C(CCC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C QMKPCZNFLUQTJZ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 229930012538 Paclitaxel Natural products 0.000 description 1
- 241001165494 Rhodiola Species 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 229930182486 flavonoid glycoside Natural products 0.000 description 1
- 150000007955 flavonoid glycosides Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229960001592 paclitaxel Drugs 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229960000292 pectin Drugs 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- NGFFRJBGMSPDMS-UHFFFAOYSA-N psi-Taraxasterol Natural products CC12CCC(O)C(C)(C)C1CCC1(C)C2CCC2C3C(C)C(C)=CCC3(C)CCC21C NGFFRJBGMSPDMS-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- HUTYZQWCTWWXND-NCTFTGAASA-N taraxasterol Natural products C[C@H]1[C@H]2C3=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]4(C)[C@]3(C)C[C@H](O)[C@@]2(C)CCC1=C HUTYZQWCTWWXND-NCTFTGAASA-N 0.000 description 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a preparation method of a traditional Chinese medicine source composition and application of the traditional Chinese medicine source composition in preparing anti-saccharification cosmetic products. Specifically, the invention discloses a rhodiola rosea extract and dandelion extract which are prepared from 70-90% by weight: 10-30% of the formulated composition. Biochemical test shows that the composition has synergistic protein glycosylation inhibiting activity, the inhibiting activity is obviously higher than that of single extract, and the composition has very low cytotoxicity and can be used as an anti-saccharification component for preparing cosmetic products. The invention also discloses application of the composition from the traditional Chinese medicine as a cosmetic ingredient to preparation of anti-saccharification face cream.
Description
Technical Field
The invention relates to a preparation method of an anti-saccharification traditional Chinese medicine composition and application of the anti-saccharification traditional Chinese medicine composition in manufacturing beauty products, and belongs to the field of cosmetics.
Background
Brownlee in 1984 reported the presence of advanced glycation end products (AGEs) in vivo. AGEs refer to a complex class of glycosylation products produced by biological macromolecules (nucleic acids, proteins, and lipids) through non-enzymatic catalytic mechanisms. Non-enzymatically catalyzed glycosylation reactions primarily refer to a series of chemical reactions that occur between the terminal free carbonyl groups of reducing monosaccharide molecules and the free amino groups in nucleic acid, protein and lipid macromolecules (FIG. 1). Studies have found that AGEs products in vivo can be divided into three major categories: non-crosslinked non-fluorescent product, and non-crosslinked fluorescent product. More than 20 AGEs products have been identified from human blood and tissues.
AGEs are potentially toxic molecules that threaten human health. For example, glycosylation of protein molecules in vivo may result in changes in the secondary structure of the protein molecule, thereby affecting the function of the protein, until it leads to cell damage. In addition, collagen is an important tissue protein in the skin, and as the age and high-sugar eating habit increase, collagen is gradually saccharified, and the skin becomes hard and black, and finally skin aging is caused and the beauty is affected. Therefore, if the glycosylation level of biological macromolecules in the body can be effectively inhibited, the biological macromolecules can be helpful for improving some disease states, delaying aging and keeping the young state of skin. Initial studies have found that some natural products with antioxidant activity are effective in inhibiting AGEs formation, i.e., have Anti-glycation (Anti-glycation) activity. As research proceeds, researchers have found that more different classes of natural products are able to inhibit AGEs formation. Natural products with anti-glycation activity include polyphenols, polysaccharides, terpenoids, vitamins, alkaloids and polypeptides, which inhibit AGEs formation by different mechanisms.
Natural products are an important source of anti-glycation active products, and the traditional Chinese medicine extract is rich in various natural products. The traditional Chinese medicine extract obtained by screening in the earlier stage of the project group has obvious anti-saccharification activity. Considering that different types of natural products are used for resisting the formation of AGEs through different mechanisms, different traditional Chinese medicine extracts are combined, and the combination of different AGEs inhibition mechanisms is used for seeking a traditional Chinese medicine extract composition with synergistic anti-saccharification activity.
The research history of traditional Chinese medicine on beauty can be traced to thousands of years ago, and in recent years, chinese herbal medicine cosmetics are increasingly popular with consumers. The Chinese herbal medicine cosmetics adopt the guidance of Chinese medicine theory, which is also the largest difference between the Chinese herbal medicine cosmetics and other cosmetics. The beauty product containing the Chinese herbal medicines has obvious effect and high safety, and is welcomed by consumers. RHODIOLA ROSEA (RHODIOLA ROSEA) is a perennial herb. The medicinal part of rhodiola root is root, its root is strong and upright. Rhodiola rosea has the effects of tonifying qi, clearing lung, improving intelligence, nourishing heart, astringing, stopping bleeding, removing stasis and relieving swelling. Studies have reported that the roots of rhodiola rosea are rich in various essential oils (e.g., monoterpene hydrocarbons, monoterpene alcohols, linear fatty alcohols, n-decanol, geraniol), fats, waxes, sterols, glycosides, organic acids (e.g., oxalic acid, citric acid, malic acid, gallic acid, succinic acid), polyphenols (e.g., tannins), flavones, and isoflavones, and proteins. Dandelion (TARAXACUM MONGOLICUM) belongs to the family of the asteraceae and perennial herbs. The herba Taraxaci whole plant contains taraxasterol, choline, inulin, pectin, etc. Dandelion is sweet in flavor, slightly bitter and cold in nature. The dandelion extract has the effects of resisting inflammation and infectious diseases. Researchers have also isolated various polysaccharides, flavonoid glycosides, organic acids, alkaloids, fats, proteins, etc. from dandelion extracts. So far, no report on the pharmacodynamic activity of single components or compositions of dandelion extract and rhodiola rosea extract in inhibiting AGEs formation is seen.
Disclosure of Invention
The invention aims to solve the technical problem of providing a composition prepared by mixing two traditional Chinese medicine extracts, namely RHODIOLA ROSEA (RHODIOLA ROSEA) extract and dandelion (TARAXACUM MONGOLICUM) extract, and a preparation method thereof.
The invention aims to solve the technical problem, and the research discovers that compared with a single traditional Chinese medicine extract, a mixture of the rhodiola rosea extract and the dandelion extract has obviously enhanced anti-saccharification activity, and the composition has synergistic anti-saccharification activity. In addition, the rhodiola rosea extract, the dandelion extract and the mixture of the rhodiola rosea extract and the dandelion extract have low cytotoxicity.
Yet another technical problem to be solved by the present invention is that the composition of the traditional Chinese medicine extract exhibits good anti-glycation activity, and the cosmetic product, such as a face cream, is prepared using this composition of the traditional Chinese medicine as a cosmetic ingredient.
In order to solve the technical problems of the invention, the invention adopts the following technical scheme:
the first aspect of the invention relates to a composition prepared by mixing two traditional Chinese medicine extracts, namely rhodiola rosea extract and dandelion extract according to a certain proportion, and the preparation method comprises the following steps:
the composition is prepared by mixing rhodiola rosea extract and dandelion extract according to a certain weight ratio, wherein the content of the rhodiola rosea extract in the composition is more than that of the dandelion extract, and the weight percentages of the rhodiola rosea extract and the dandelion extract are as follows: dandelion extract = 70-90%:10-30%, weighing and mixing uniformly.
Further preferred compositions are prepared as follows: rhodiola rosea extract: dandelion extract = 70%: weighing and uniformly mixing 30% by weight.
In a second aspect, the present invention relates to a composition of traditional Chinese medicine origin as described above, capable of reducing the glycosylation of albumin, and in particular, in a study we compared the anti-glycation activity of two single extracts with a composition, in particular, a composition having a significantly enhanced, i.e. synergistic, anti-glycation activity, suitable as anti-glycation ingredient for the preparation of corresponding cosmetic products.
The third aspect of the invention relates to the use of the composition derived from the traditional Chinese medicine in the preparation of cosmetic products with anti-glycation activity, such as creams. And provides a specific formula of the face cream containing the traditional Chinese medicine source composition as a beautifying component and a preparation method thereof.
Drawings
Fig. 1: formation mechanism of advanced glycation end products (AGEs).
Fig. 2: anti-glycation activity studies of the different components. The four detection components are aminoguanidine, rhodiola rosea extract, dandelion extract and a preferred extract composition.
Fig. 3: anti-glycation activity IC of four components 50 . The four detection components are aminoguanidine, rhodiola rosea extract, dandelion extract and a preferred extract composition.
Detailed Description
The invention will be further illustrated with reference to specific examples. It should be understood that the detailed description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products.
Example 1: preparation method of traditional Chinese medicine source extract composition
RHODIOLA ROSEA (RHODIOLA ROSEA) extract, a reddish brown powder, is very soluble in water and is available from wuhan fuxin chemical company. Herba Taraxaci (TARAXACUM MONGOLICUM) extract, a yellow-brown powder, is readily soluble in water and is available from Wuhan Fuxin chemical Co. The preparation method of the composition comprises the following steps: the composition is prepared by mixing rhodiola rosea extract and dandelion extract according to a certain weight ratio, wherein the content of the rhodiola rosea extract in the composition is more than that of the dandelion extract, and the weight percentages of the rhodiola rosea extract and the dandelion extract are as follows: dandelion extract = 70-90%:10-30%, and mixing evenly after weighing.
Further, the preferred method of preparation of the composition is as follows: rhodiola rosea extract: dandelion extract = 70%: weighing and uniformly mixing 30% by weight.
In the specific operation, weighing 7g of rhodiola rosea extract, 3g of dandelion extract and uniformly mixing 10g of brown powder to obtain the composition.
Example 2: anti-glycation activity of traditional Chinese medicine source extract composition
The experimental method comprises the following steps:the inhibitory activity of rhodiola rosea extract, dandelion extract and the preferred composition prepared in experimental example 1 on AGEs formation was examined according to the anti-glycation activity study method proposed by Vinson and Howard in 1996. Samples of 0.5mL at a concentration of 10,20,50,100,200 μg/mL were added to 0.1M PBS buffer containing 0.5mL 20mg/mL BSA, 0.5mL 0.5M glucose and 1.0mL 1% sodium azide, ph=7.4. Incubation was carried out at 37℃for 7 days using a fluorescence spectrometer (EnSpireElmer, MA, USA), set the detection conditions to E x ＝330nm,E m Fluorescence Intensity (FI) of AGEs formation was measured =410 nm. No inhibitor was added to the control group. Anti-glycation reference positive compounds were compared using aminoguanidine.
The inhibitory activity on AGEs formation was calculated by the following formula:
inhibitory Activity (%) = [1- (FI sample-FI sample blank)/(FI control-FI control blank) ]. Times.100%
Calculation of IC by inhibitory Activity at different concentrations 50 Calculation was performed using software GraphPad Prism 8.0.
The results are as follows：
TABLE 1 anti-glycation Activity Studies of different Components
The experimental results are shown in table 1 and fig. 2. The rhodiola rosea extract or dandelion extract with various concentrations has a certain anti-saccharification activity, but the anti-saccharification activity is weaker than that of the positive compound aminoguanidine. For example, at a concentration of 200 μg/mL, the anti-glycation activities of rhodiola rosea extract and dandelion extract were 43% and 39%, respectively, whereas the anti-glycation inhibitory activity of aminoguanidine, a positive compound, was 78% (similar to the data reported in the literature), but the rhodiola rosea extract and dandelion extract were 70%: the preferred composition of 30% by weight has significantly improved anti-glycation inhibiting activity. As shown in FIG. 3, IC for inhibiting AGEs formation was calculated using GraphPad Prism 8.0 for the four components 50 66.21 μg/mL-aminoguanidine, 262.6 μg/mL-rhodiola rosea extract, 315.7- μg/mL dandelion extract, 48.92 μg/mL-extract composition, respectively.
Example 3: synergistic effect of anti-glycation activity of traditional Chinese medicine source extract composition is proved
The experimental method comprises the following steps:the synergy index is judged by adopting a gold positive average q value method, and the q value is obtained by the following formula:
q＝P A+B /(P A +P B -P A ×P B ). P in the formula A 、P B And P A+B Treatment rates were set A, B and two combination groups, respectively.
q < 1 indicates antagonism after the two extracts are combined; q > 1, indicating synergy after the two extracts are combined, and q=1, indicating additive effect after the two extracts are combined.
According to the above synergy index calculation method, we respectively measure the rhodiola rosea extract, dandelion extract and 70% of the two by weight of single dose: the preferred combination of 30% mixing, specific concentrations are shown in table 2. The inhibition activity of AGEs formation was examined in the same manner as in example 2.
The results are as follows：
TABLE 2 anti-glycation Activity Studies of two Components
The results of the measurement are shown in Table 2. At the three selected concentrations, the preferred compositions exhibit synergistic anti-glycation activity (q > 1) of both extracts, with a significant enhancement in anti-glycation activity. In the early stage of the project, we screen some traditional Chinese medicine extracts with anti-saccharification activity, and the traditional Chinese medicine extracts are combined two by two so as to screen a composition with obvious enhancement effect. We speculate that since different extracts are rich in different anti-glycation active natural product components, such as polyphenols or polysaccharides. If the two extracts adopt different anti-glycation inhibition mechanisms, the combination of the two extracts has mutual enhancement effect, and finally, the synergistic anti-glycation activity is achieved. Compositions, particularly preferred compositions, have synergistically enhanced anti-glycation effects compared to single extracts, and can be used as anti-glycation ingredients.
Example 4: cytotoxicity of Chinese medicinal source extract composition
The experimental method comprises the following steps:the cytotoxicity of the compounds was detected using the CCK-8 kit. Specifically, hepG2 cells, MCF-7 cells and A549 cells were inoculated into 96-well plates, respectively, and cultured at about 5000 cells/200. Mu.L per wellLiquid, cells were cultured overnight. Test compounds were added to each well at different concentrations and incubation was continued for 48 hours. And adding 10 mu L of CCK-8 reagent into each hole, uniformly mixing, continuously culturing for 1-4 hours, observing that the color of the culture solution changes obviously, detecting by using an enzyme-labeled instrument, and measuring the light absorption value of 450 nm. Paclitaxel was used as a positive control.
The results were as follows:
the results are shown in Table 3, and the cell experiment detection shows that the rhodiola rosea extract, the dandelion extract and the preferred combination of the rhodiola rosea extract and the dandelion extract have no obvious cytotoxicity. In connection with example 2, example 3, the combination of both is especially preferred for use as an anti-glycation ingredient for the preparation of cosmetic products.
Table 3: cytotoxicity of different Components against mammalian cells
Example 5: anti-saccharification face cream prepared from traditional Chinese medicine source extract composition as beautifying component
An anti-saccharification face cream comprises the following components in parts by weight:
the cosmetic ingredients appearing herein are all INCI (International Nomenclature of Cosmetic Ingredients), the name specified by the international cosmetic raw material nomenclature.
An oil phase: 3.0 parts of mineral oil, 2.0 parts of squalane, 2.0 parts of caprylic/capric triglyceride, 0.4 part of polyoxyethylene cetylstearyl diether, 2.0 parts of polydimethylsiloxane, and 4.0 parts of glycerol stearic acid/PEG-100 stearic acid;
aqueous phase:anti-glycation composition (preferred composition in example 1) 5.0 parts3.0 parts of glycerin, 4.0 parts of propylene glycol, 0.1 part of allantoin, 0.15 part of carbomer, 74.03 parts of deionized water, 0.02 part of essence, 0.15 part of methylparaben and 0.15 part of propylparaben.
The preparation method comprises the following steps:according to the above formulation, the individual components were weighed, with each mass part being 1g. Mixing the oil phase components, stirring and heatingTo 80 ℃; mixing the water phase components (except essence), stirring and heating to 80deg.C; slowly adding the oil phase into the water phase, stirring while adding, keeping the temperature of the water phase constant at 80 ℃, and continuously stirring for 5 minutes; cooling to 45deg.C, adding essence, stirring, cooling to 25deg.C, and packaging.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.
Claims (5)
1. A traditional Chinese medicine-derived composition with anti-glycation activity is characterized in that: the traditional Chinese medicine-derived composition comprises the following components in percentage by weight: the composition of the traditional Chinese medicine source has synergistic activity of inhibiting the formation of advanced glycosylation end products, wherein the rhodiola rosea extract is 70% and the dandelion extract is 30% and is purchased from Wuhan Fuxin chemical industry Co.
2. The method for preparing a traditional Chinese medicine-derived composition as claimed in claim 1, wherein: the method comprises the following steps: according to the weight percentage in claim 1, the rhodiola rosea extract and the dandelion extract are respectively weighed, and the two powders are mixed and evenly mixed, thus obtaining the composition of the traditional Chinese medicine source.
3. Use of the traditional Chinese medicine source composition according to claim 1 for preparing a cosmetic product.
4. Use according to claim 3, characterized in that: the cosmetic product is selected from a cream, a toner, an emulsion or a mask.
5. An anti-glycation facial cream, characterized in that: the face cream contains the traditional Chinese medicine-derived composition as claimed in claim 1, and the formula and the weight parts of the face cream are as follows: the traditional Chinese medicine-derived composition of claim 1, wherein the composition comprises 5.0 parts of mineral oil, 3.0 parts of squalane, 2.0 parts of caprylic/capric triglyceride, 0.4 parts of polyoxyethylene cetylstearyl diether, 2.0 parts of polydimethylsiloxane, 4.0 parts of glycerol stearic acid/PEG-100 stearic acid, 3.0 parts of glycerol, 4.0 parts of propylene glycol, 0.1 parts of allantoin, 0.15 parts of carbomer, 74.03 parts of deionized water, 0.02 parts of essence, 0.15 parts of methylparaben and 0.15 parts of propylparaben.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111357752.XA CN113876669B (en) | 2021-11-16 | 2021-11-16 | Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111357752.XA CN113876669B (en) | 2021-11-16 | 2021-11-16 | Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113876669A CN113876669A (en) | 2022-01-04 |
| CN113876669B true CN113876669B (en) | 2023-10-31 |
Family
ID=79017684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111357752.XA Active CN113876669B (en) | 2021-11-16 | 2021-11-16 | Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113876669B (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030012562A (en) * | 2001-08-01 | 2003-02-12 | 주식회사 웰스킨 | Whitening composition containing rhodiola sachalinensis a. bor extraction |
| CN104095896A (en) * | 2014-07-24 | 2014-10-15 | 河南中医学院 | Application of dandelion extract in preparing hypoglycemic agent |
| WO2016163652A1 (en) * | 2015-04-08 | 2016-10-13 | 김경일 | Health supplement food for promotion of hair growth, mitigation and alleviation of hair loss, regulation of blood glucose, and alleviation and relief of gastric disorder symptoms |
| CN107823018A (en) * | 2017-12-19 | 2018-03-23 | 广东德新科技孵化器有限公司 | A kind of water conservation moisture saver mask liquid containing ossein and preparation method thereof |
| CN111437237A (en) * | 2020-06-02 | 2020-07-24 | 华南协同创新研究院 | Skin care composition with antioxidant, anti-saccharification and anti-aging effects and application thereof |
| CN111494224A (en) * | 2020-06-16 | 2020-08-07 | 四川天晟制药有限公司 | Whitening and spot-fading composition, skin care product and preparation method thereof |
| CN112006959A (en) * | 2020-09-15 | 2020-12-01 | 上海应用技术大学 | Antioxidant whitening cream containing dandelion and tea extracts and preparation method thereof |
-
2021
- 2021-11-16 CN CN202111357752.XA patent/CN113876669B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030012562A (en) * | 2001-08-01 | 2003-02-12 | 주식회사 웰스킨 | Whitening composition containing rhodiola sachalinensis a. bor extraction |
| CN104095896A (en) * | 2014-07-24 | 2014-10-15 | 河南中医学院 | Application of dandelion extract in preparing hypoglycemic agent |
| WO2016163652A1 (en) * | 2015-04-08 | 2016-10-13 | 김경일 | Health supplement food for promotion of hair growth, mitigation and alleviation of hair loss, regulation of blood glucose, and alleviation and relief of gastric disorder symptoms |
| CN107823018A (en) * | 2017-12-19 | 2018-03-23 | 广东德新科技孵化器有限公司 | A kind of water conservation moisture saver mask liquid containing ossein and preparation method thereof |
| CN111437237A (en) * | 2020-06-02 | 2020-07-24 | 华南协同创新研究院 | Skin care composition with antioxidant, anti-saccharification and anti-aging effects and application thereof |
| CN111494224A (en) * | 2020-06-16 | 2020-08-07 | 四川天晟制药有限公司 | Whitening and spot-fading composition, skin care product and preparation method thereof |
| CN112006959A (en) * | 2020-09-15 | 2020-12-01 | 上海应用技术大学 | Antioxidant whitening cream containing dandelion and tea extracts and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 余琴 ; 刘迅 ; 邢莎莎 ; 刘丽慧 ; 李相芬 ; 任丽 ; 刘晓艳 ; 宁宁 ; .红景天苷在疾病中的作用及机制研究进展.中国药师.2020,(第03期),第526-529页. * |
| 梅全喜.《现代中药药理与临床应用手册》.中国中医药出版社,2016,第835页. * |
| 王文君 ; 欧阳克蕙 ; 许文凤 ; 徐明生 ; 上官新晨 ; 蒋艳 ; .9种植物粗多糖体外降脂及抑制非酶糖基化活性的研究.江西农业大学学报.2013,(第03期),第593-597页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113876669A (en) | 2022-01-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kumari et al. | Screening of antioxidant potential of selected barks of Indian medicinal plants by multiple in vitro assays | |
| Nabavi et al. | Biological activities of flavonoid-rich fraction of Eryngium caucasicum Trautv. | |
| CN108992372B (en) | Moisturizing composition containing snow lotus herb extract and skin care product thereof | |
| Kanlayavattanakul et al. | Preparation and efficacy assessment of malva nut polysaccharide for skin hydrating products | |
| Karpiuk et al. | Total phenolic and flavonoid content, antioxidant activity of Ficaria verna | |
| Leny et al. | The Effectiveness of Pandan Wangi Leaves (Pandanus Amaryllifolius Roxb.) Body Scrub Formulation in Smoothing the Skin | |
| CN113876669B (en) | Anti-saccharification traditional Chinese medicine composition, preparation method thereof and application thereof in cosmetic product | |
| CN114948813B (en) | Anti-saccharification and anti-aging natural product composition, preparation method thereof and application thereof in oral cosmetic product | |
| CN116019187A (en) | Anti-glycation composition of natural source, preparation method and application in oral cosmetic product | |
| Ghanwat et al. | Formulation and Evaluation of Herbal Soap | |
| CN115531244A (en) | Composition and preparation method and application thereof | |
| CN113876668B (en) | Anti-saccharification plant source composition, preparation method thereof and application thereof in cosmetic product | |
| KR20130107123A (en) | Compositions containing extracts of glycine gracilis | |
| CN112891278A (en) | Whitening composition, preparation method and application | |
| CN113876640A (en) | Anti-saccharification seaweed-derived composition, preparation method thereof and application thereof in beauty products | |
| Diadora et al. | Potential Effect of Avena sativa’s Cream on Skin Hydration | |
| CN110237012A (en) | A kind of bletilla striata hand lotion and preparation method thereof for preventing and treating chapped skin | |
| CN115192491B (en) | Cosmetic composition, and preparation method and application thereof | |
| CN117815128A (en) | Expression promoter of proline-rich small protein gene SPRR2A | |
| Mokhtar et al. | Formulation of herbal cream based on Ziziphus Mauritiana leaves extract and evaluation on physicochemical properties | |
| Gunawan et al. | Hair Growth Test in Male Rabbits (Oryctolagus cuniculus) With Variations in The Concentration of Ethanol Extract Terentang (Campnosperma brevipetiolatum Volkens) Stem | |
| CN117815124A (en) | Expression promoter of filaggrin gene FLG | |
| CN117883330A (en) | Expression promoter of peroxisome proliferation-activated receptor genes PPARA and PPARG | |
| CN117815129A (en) | Expression promoter of proline-rich small protein gene SPRR2A | |
| CN117815127A (en) | Expression promoter of filaggrin gene FLG |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |