CN113876668B - Anti-saccharification plant source composition, preparation method thereof and application thereof in cosmetic product - Google Patents

Anti-saccharification plant source composition, preparation method thereof and application thereof in cosmetic product Download PDF

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CN113876668B
CN113876668B CN202111356424.8A CN202111356424A CN113876668B CN 113876668 B CN113876668 B CN 113876668B CN 202111356424 A CN202111356424 A CN 202111356424A CN 113876668 B CN113876668 B CN 113876668B
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extract
composition
parts
plant
glycation
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CN113876668A (en
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姜燕飞
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Shanghai Qingyan Boshi Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a plant source composition, a preparation method thereof and application thereof in preparing anti-saccharification cosmetic products. Specifically, the invention discloses a white hyacinth bean extract and green algae extract which are prepared from 60-90% by mass: 10-40% of the formulated composition. Further preferred is a mass percentage of 60%:40% of the formulated composition. Biochemical tests show that the composition has synergistically enhanced anti-glycation activity and is basically free of cytotoxicity. The invention also discloses the use of such a plant-derived composition as an anti-glycation ingredient for the manufacture of cosmetic products, such as anti-glycation creams.

Description

Anti-saccharification plant source composition, preparation method thereof and application thereof in cosmetic product
Technical Field
The invention relates to an anti-saccharification plant source composition, a preparation method thereof and application thereof in making beauty products, belonging to the field of cosmetics.
Background
Brownlee in 1984 reported the presence of advanced glycation end products (AGEs) in vivo. AGEs refer to a complex class of glycosylation products produced by biological macromolecules (nucleic acids, proteins, and lipids) through non-enzymatic catalytic mechanisms. Non-enzymatically catalyzed glycosylation reactions primarily refer to a series of chemical reactions that occur between the terminal free carbonyl groups of reducing monosaccharide molecules and the free amino groups in nucleic acid, protein and lipid macromolecules (FIG. 1). Studies have found that AGEs products in vivo can be divided into three major categories: non-crosslinked non-fluorescent product, and non-crosslinked fluorescent product. Researchers have isolated and identified 20 or more AGEs from human blood, tissue and food.
AGEs are potentially toxic molecules threatening human health, and a large number of AGEs accumulated in the body can cause skin aging, bone weakness, alzheimer's disease, and eye abnormalities. For example, glycosylation of protein molecules in vivo may result in changes in the secondary structure of the protein molecule, thereby affecting the function of the protein, until it leads to cell damage. In addition, collagen is an important tissue protein in the skin, and as the age and high-sugar eating habit increase, collagen is gradually saccharified, and the skin becomes hard and black, and finally skin aging is caused and the beauty is affected. Therefore, if the glycosylation level of biological macromolecules in the body can be effectively inhibited, the biological macromolecules can be helpful for improving some disease states, delaying aging and keeping the young state of skin. It has been found that partial natural products with antioxidant activity are effective in inhibiting AGEs formation, i.e. Anti-glycation activity, while the cytotoxicity of these natural products is relatively small. As research is advanced, more and more natural products capable of inhibiting AGEs formation are discovered, which include polyphenols, polysaccharides, terpenoids, vitamins, alkaloids, and polypeptides. These natural products inhibit the formation of AGEs by different mechanisms.
Natural products are an important source of anti-glycation active products. The partial plant extracts obtained by the early screening of the project group have obvious anti-saccharification activity, different natural products are rich in the anti-AGEs through different mechanisms, and different plant extracts are rich in different natural product components. Combining different plant extracts, combining different AGEs inhibition mechanisms, strives to find plant extract compositions with synergistically enhanced anti-glycation activity.
The history of human cosmetology using herbal medicine has been traced back to thousands of years ago, and has been widely practiced in folk and palace, and the role of herbal medicine in cosmetology has been in depth. The herbal beauty product has small irritation and high safety, and is welcomed by consumers. White hyacinth beans (DOLICHOS LABLAB), annual entangled grass vines. The white hyacinth bean has the functions of strengthening spleen, eliminating dampness and relieving summer heat. White hyacinth bean mainly contains palmitic acid, linoleic acid, elaidic acid, oleic acid, stearic acid, saponin, polysaccharide, monosaccharide, protein, etc. In addition, green algae (CHLOROPHYTA) are unicellular algae living in fresh water, which are rich in proteins, amino acids, unsaturated fatty acids, polysaccharides, and the like. Green algae is a natural alkaline food, and can regulate physical health and enhance immunity. No report has been made so far on the pharmacodynamic activity of white hyacinth bean (DOLICHOS LABLAB) extract and green algae (CHLOROPHYTA) extract, single components or compositions in inhibiting AGEs formation.
Disclosure of Invention
The invention aims to provide a composition prepared by mixing two plant extracts, namely white hyacinth bean (DOLICHOS LABLAB) extract and green alga (CHLOROPHYTA) extract, and a preparation method thereof.
Yet another technical problem to be solved by the present invention is that the mixture of white lablab seed extract and green algae extract has significantly enhanced synergistic anti-glycation activity compared to single ingredients. In addition, white lablab seed extract, green algae extract and their mixture have very low cytotoxicity.
Yet another technical problem to be solved by the present invention is that the plant extract composition exhibits good anti-glycation activity, contributing to an improvement of the ageing state of the skin. The plant extract composition can be used as cosmetic component for preparing cosmetic product such as facial cream.
In order to solve the technical problems of the invention, the invention adopts the following technical scheme:
the first aspect of the invention relates to a composition prepared by mixing two plant extracts, namely white hyacinth bean extract and green algae extract according to a certain proportion, and the preparation method comprises the following steps:
the composition is prepared by mixing white hyacinth bean extract and green algae extract according to a certain weight ratio, wherein the white hyacinth bean extract content in the composition is more than that in the green algae extract, and the weight percentages of the white hyacinth bean extract and the green algae extract are as follows: green algae extract = 60-90%:10-40%, weighing and mixing uniformly.
Further preferred compositions are prepared as follows: white hyacinth bean extract: green algae extract = 60%: weighing and uniformly mixing 40% by weight.
The second aspect of the present invention relates to the effect of a plant extract composition on the glycosylation of albumin, demonstrating a significantly enhanced synergistic anti-glycation activity compared to the single extract, the composition being suitable as anti-glycation ingredient for the preparation of a corresponding cosmetic product.
The third aspect of the invention relates to the use of a composition of vegetable origin as described above for the preparation of a cosmetic product having anti-glycation activity, and to a cream product comprising a composition of vegetable origin as described above.
Drawings
Fig. 1: formation mechanism of advanced glycation end products (AGEs).
Fig. 2: anti-glycation activity studies of the different components. The four detection components are aminoguanidine, white hyacinth bean extract, green algae extract and extract preferred composition.
Fig. 3: anti-glycation activity IC of four components 50 . The four detection components are aminoguanidine, white hyacinth bean extract, green algae extract and extract preferred composition.
Detailed Description
The following examples and activity experiments are provided to further illustrate the invention, but are not intended to limit the scope of the invention.
The specific techniques or conditions are not identified in the examples and are described in the literature in this field or are carried out in accordance with the product specifications. The reagents or equipment used were conventional products available for purchase through regular channels, with no manufacturer noted.
The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the examples described below, unless otherwise specified, are all commercially available products.
Example 1: preparation method of plant-derived extract composition
White hyacinth bean (DOLICHOS LABLAB) extract, brown powder, readily soluble in water, purchased from shanxi new world biotechnology limited. Green algae (Chlorophyta) extract, green powder, is readily soluble in water, and is purchased from Shaanxi Shidu pharmaceutical chemicals Co. The preparation method of the composition comprises the following steps: the composition comprises the white hyacinth bean extract and the green alga extract according to the weight percentage of the white hyacinth bean extract to be more than the green alga extract: green algae extract = 60-90%:10-40%, and mixing evenly after weighing.
Further, the preferred method of preparation of the composition is as follows: white hyacinth bean extract: green algae extract = 60%: weighing and uniformly mixing 40% by weight. Weighing 6g of white hyacinth bean extract and 4g of green algae extract, and uniformly mixing the powder to obtain the composition.
Example 2: anti-glycation activity of plant-derived extract compositions
Experimental method: the inhibitory activity of white lablab seed extract, green algae extract and preferred compositions prepared in experimental example 1 on AGEs formation was examined according to the study methods proposed by Vinson and Howard in 1996. Samples of 0.5mL at a concentration of 10,20,50,100,200 μg/mL were added to 0.1M PBS buffer containing 0.5mL 20mg/mL BSA, 0.5mL 0.5M glucose and 1.0mL 1% sodium azide, ph=7.4. Incubating at 37 deg.C for 7 days, and measuring with fluorescence spectrometerPerkin-Elmer, mass., USA) setting the detection conditions as E x ＝330nm,E m Fluorescence Intensity (FI) of AGEs formation was measured =410 nm. No inhibitor was added to the control group. Anti-glycation positive reference compounds were compared using aminoguanidine.
The inhibitory activity on AGEs formation was calculated by the following formula:
inhibitory Activity (%) = [1- (FI sample-FI sample blank)/(FI control-FI control blank) ]. Times.100%
Calculation of IC by anti-glycation inhibition of different concentration components 50 The calculations were performed using the software GraphPad Prism 8.0.
The results are as follows：
TABLE 1 anti-glycation Activity Studies of different Components
The experimental results are shown in table 1 and fig. 2. Both white hyacinth bean extract and green algae extract have certain anti-glycation activity, but the anti-glycation activity is weaker than that of positive compound aminoguanidine. For example, at a concentration of 200 μg/mL, the anti-glycation activities of white hyacinth bean extract and green algae extract were 51% and 45%, respectively. The positive compound aminoguanidine has an anti-glycaemic inhibitory activity of 81% (similar to the data reported in the literature). But the composition of the extract was as follows: the preferred composition of 40% by weight has significantly improved anti-glycation inhibiting activity.
As shown in FIG. 3, IC for inhibiting AGEs formation was calculated using GraphPad Prism 8.0 for the four components 50 62.54. Mu.g/mL-aminoguanidine, 213.9. Mu.g/mL-Chlorella extract, 166.7-g/mL-lablab album extract, 71.2. Mu.g/mL-extract composition, respectively.
Example 3: synergistic effect of anti-glycation activity of plant-derived extract composition was confirmed
The experimental method comprises the following steps:the synergy index is judged by adopting a gold positive average q value method, and the q value is obtained by the following formula:
q＝P A+B /(P A +P B -P A ×P B ). P in the formula A 、P B And P A+B Treatment rates were set A, B and two combination groups, respectively.
q < 1 indicates antagonism after the two extracts are combined; q > 1, indicating synergy after the two extracts are combined, and q=1, indicating additive effect after the two extracts are combined.
According to the above-mentioned synergy index calculation method, we measured a single dose of green algae extract, white hyacinth bean extract, and 60% by weight of the two: preferred combinations of 40% mixing are shown in Table 2 for specific concentrations. The inhibition activity of AGEs formation was examined in the same manner as in example 2.
The results are as follows：
TABLE 2 anti-glycation Activity Studies of two Components
The results of the measurement are shown in Table 2. At the three selected concentrations, the preferred compositions achieve a significant enhancement in anti-glycation activity, exhibiting synergistic anti-glycation activity of the two extracts. In the early stage of the project, we screened some plant extracts with anti-saccharification activity, and screened the composition with obvious enhancement effect by combining two plants. We speculate that since different extracts are rich in different anti-glycation active natural product components, such as polyphenols or polysaccharides. If the two extracts use different anti-glycation inhibition mechanisms, the combination may have mutual enhancing effect, and finally, synergistic anti-glycation activity is achieved. Compositions, particularly preferred compositions, have synergistically enhanced anti-glycation effects compared to single extracts, and can be used as anti-glycation ingredients.
Example 4: cytotoxicity of plant-derived extract compositions
The experimental method comprises the following steps:the cytotoxicity of the compounds was detected using the CCK-8 kit. Specifically, hepG2 cells, MCF-7 cells and A549 cells were inoculated into 96-well plates, respectively, and the cells were cultured overnight at about 5000 cells/200. Mu.L of the culture medium per well. Test compounds were added to each well at different concentrations and incubation was continued for 48 hours. And adding 10 mu L of CCK-8 reagent into each hole, uniformly mixing, continuously culturing for 1-4 hours, observing that the color of the culture solution changes obviously, detecting by using an enzyme-labeled instrument, and measuring the light absorption value of 450 nm. Paclitaxel was used as a positive control.
The results were as follows:
the results are shown in Table 3, and cell experiments have found that the preferred compositions of white lablab seed extract, green algae extract and both have no significant cytotoxicity. This is relevant to the fact that they are derived from plant extracts. In combination with example 2 and example 3, the compositions of both are particularly preferred compositions suitable for use as anti-glycation ingredients in the preparation of cosmetic products.
TABLE 3 cytotoxicity of different fractions on mammalian cells
Example 4: cosmetic composition prepared from plant extract for preparing anti-saccharification facial cream
An anti-saccharification face cream comprises the following components in parts by weight:
the cosmetic ingredients appearing herein are all INCI (International Nomenclature of Cosmetic Ingredients), the name specified by the international cosmetic raw material nomenclature.
An oil phase: 3.0 parts of mineral oil, 2.0 parts of squalane, 2.0 parts of caprylic/capric triglyceride, 0.4 part of polyoxyethylene cetylstearyl diether, 2.0 parts of polydimethylsiloxane, and 4.0 parts of glycerol stearic acid/PEG-100 stearic acid;
aqueous phase:10.0 parts of an anti-glycation composition (preferred composition in example 1)3.0 parts of glycerin, 4.0 parts of propylene glycol, 0.1 part of allantoin, 0.15 part of carbomer, 69.03 parts of deionized water, 0.02 part of essence, 0.15 part of methylparaben and 0.15 part of propylparaben.
The preparation method comprises the following steps:according to the above formulation, the individual components were weighed, with each mass part being 1g. Mixing the oil phase components, stirring and heating to 80 ℃; mixing the water phase components (except essence), stirring and heating to 80deg.C; slowly adding the oil phase into the water phase, stirring while adding, keeping the temperature of the water phase constant at 80 ℃, and continuously stirring for 5 minutes; cooling to 45deg.C, adding essence, stirring, cooling to 25deg.C, and packaging.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.

Claims (5)

1. A composition of plant origin having anti-glycation activity, characterized in that: the composition of plant sources comprises the following components in percentage by weight: 60% of white hyacinth bean extract and 40% of green alga extract, wherein the plant-derived composition has synergistically enhanced activity of inhibiting formation of advanced glycosylation end products, the white hyacinth bean extract is purchased from Shaanxi New Tian Domain biotechnology Co., ltd, and the green alga extract is purchased from Shaanxi Diu pharmaceutical chemical Co., ltd.
2. A process for the preparation of a plant-derived composition as claimed in claim 1, characterized in that: the method comprises the following steps: according to the weight percentage in claim 1, the white hyacinth bean extract and the green algae extract are respectively weighed, and the two powders are uniformly mixed, thus obtaining the composition of the plant source extract.
3. Use of the plant-derived composition of claim 1 for the preparation of a cosmetic product.
4. Use according to claim 3, characterized in that: the cosmetic product is selected from a cream, a toner, an emulsion or a mask.
5. An anti-glycation facial cream, characterized in that: the face cream contains the plant-derived composition of claim 1, and the formula and the weight parts of the face cream are as follows: 3.0 parts of mineral oil, 2.0 parts of squalane, 2.0 parts of caprylic/capric triglyceride, 0.4 part of polyoxyethylene cetylstearyl diether, 2.0 parts of polydimethylsiloxane, 4.0 parts of glycerol stearic acid/PEG-100 stearic acid, 10.0 parts of the plant-derived composition according to claim 1, 3.0 parts of glycerol, 4.0 parts of propylene glycol, 0.1 part of allantoin, 0.15 part of carbomer, 69.03 parts of deionized water, 0.02 part of essence, 0.15 part of methylparaben and 0.15 part of propylparaben.
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