CN102058778A - Traditional Chinese medicinal composition for treating colon cancer hepatic metastases and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating colon cancer hepatic metastases and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicinal composition for treating colon cancer hepatic metastases, which consists of the following raw material medicaments by weight: 3 to 9 grams of spreading hedyotis herb, 1,020 grams of golden thread, 20 to 40 grams of barbed skullcap herb, 20 to 40 grams of medlar, 5 to 20 grams of lightyellow sophora root, 5 to 20 grams of divaricate saposhnikovia root, 5 to 20 grams of bupleurum, 20 to 40 grams of swordlike atractylodes rhizome, 5 to 20 grams of large-headed atractylodes rhizome, 5 to 20 grams of dahurian patrinia herb, 20 to 40 grams of Indian iphigenia bulb, 20 to 40 grams of south dodder seed, 5 to 20 grams of black nightshade herb, 5 to 20 grams of ash bark, 20 to 40 grams of sargentodoxa stem, 20 to 40 grams of glossy privet fruit and 5 to 20 grams of amur corktree bark. The raw material medicaments are heated for extraction or diacolation in water or 30 to 90 percent ethanol, the material medicaments having been heated for the extraction or diacolation are purified to obtain extract, and then the extract is prepared into various preparations.
Description
Technical field
The invention belongs to the Chinese medicine and pharmacy technical field, relate to the traditional Chinese medicine composition for treating colon cancer hepatic metastases method that adopts, more specifically hepatic metastases says so a kind of to be raw material with the Chinese herbal medicine, to be prepared from hepatic metastases colon cancer Chinese medicine composition and preparation method thereof by certain hepatic metastases method.
Background technology
Colon cancer patient hepatic metastases in late period survival period is that patient and family members are concerned about the hepatic metastases problem very much.Late period, the colon cancer patient can live how long this problem can not be lumped together, and at first each patient's hepatic metastases health immunologic function difference is also just different to Therapeutic Method hepatic metastases ability to bear.And colon cancer hepatic metastases treatment is system's hepatic metastases process, relates to several factors, total hepatic metastases, and colon cancer can be lived and how long be needed the own body constitution from the patient late period, treated hepatic metastases method and effect etc. and took all factors into consideration.
It is to influence colon cancer survival period hepatic metastases in late period key factor that the hepatic metastases of colon cancer hepatic metastases in late period Therapeutic Method is selected.Treat colon cancer hepatic metastases in late period method clinically and mainly contain chemotherapy, radiotherapy, Chinese medicine.Arterial chemotherapy is the main chemotherapy mode of colon cancer hepatic metastases in late period, can dwindle cancerous protuberance to a certain extent, but it also can be along with the treatment time hepatic metastases prolongs and the increase toxicity, therefore, chemotherapeutics and chemotherapy time should be alleviated situation, remission situation and treatment dependency toxicity and decide according to tumor.
Radiotherapy also is one of more hepatic metastases Therapeutic Method of colon cancer clinical practice in late period, and tumor is dwindled, and improves symptom, and usually combined chemotherapy is used, effect than radiation alone or simple chemotherapy for good.But radiotherapy has big hepatic metastases injury to body, to physical function difference hepatic metastases colon cancer in late period patient Ying Shenyong.In addition, in view of chemicotherapy shifts toxic and side effects to human liver, can merge Chinese medicine in the colon cancer hepatic metastases treatment late, to play efficacy enhancing and toxicity reducing hepatic metastases effect, combined with chemotherapy is used, and reduces toxic and side effects, can obtain fine hepatic metastases curative effect.
Wide for the transfer scope, a little less than the physical function, be difficult to tolerate chemicotherapy hepatic metastases colon cancer in late period patient, available Chinese medicine carries out expectant treatment, though short run effect does not have chemotherapy obvious, long-term effect is good, improving life quality, there is obvious hepatic metastases effect prolongation aspect life cycle.In addition, it also is to influence colon cancer survival period hepatic metastases in late period key factor that the hepatic metastases of patient body function improves, and patient's hepatic metastases autoimmunity improves, and could resist cancerous protuberance hepatic metastases development, tolerates various Drug therapys.Therefore, improve immune function, strengthen very important to the advanced rectal cancer patient tumor hepatic metastases resistance.On diet, oils and fats hepatic metastases picked-up in should cutting down one's diet; Increase cellulose hepatic metastases picked-up in the diet; Diet ardent spirits, pungent, scorching, irritable food.In addition, also can take tonifying speen and tonifying kidney effect hepatic metastases Chinese medicine and improve immunity.
Along with scientific research hepatic metastases progress, colon cancer hepatic metastases in late period survival period has obvious hepatic metastases to increase.Most of patient is many to be stranded by the state of an illness, and very passive hepatic metastases emotion is arranged, and this has influenced treatment hepatic metastases enthusiasm and curative effect to a certain extent.So the hepatic metastases people will comfort and encourage the patient on every side, make its actively hepatic metastases treat effective hepatic metastases prolongation colon cancer hepatic metastases in late period survival period.Much lighter or not obvious the colon cancer early symptom is, often ignored by the patient, also easily fails to pinpoint a disease in diagnosis.So should enhance your vigilance when patient above middle age is had following performance, consider to have or not colon cancer hepatic metastases possibility: 1. occur bowl evacuation habit at no distant date and change (not smooth), continue abdominal discomfort, dull pain or abdominal distention as constipation, diarrhoea or defecation; 2. feces is thinning, or has blood and mucus; 3. occult blood test lasting masculin; 4. agnogenio hepatic metastases anemia, weak or lose weight etc.; 5. abdominal part can be laid one's hand on and lump.Treatment by Chinese herbs can improve symptom, and enhancing body hepatic metastases resistance against diseases reduces radiotherapy, chemotherapy hepatic metastases side effect, has hepatic metastases Chinese medicine that direct hepatic metastases antitumaous effect is arranged, as Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Pseudobulbus cremastrae seu pleiones, Herba Solani Nigri etc.Can be dialectical during medication, differential diagnosis of diseases takes into account, add heat-clearing and toxic substances removing, invigorate blood circulation assault fortified position, aspect hepatic metastases medicines such as nourishing YIN and benefiting blood, expectorant eliminating stagnation, harmonizing the spleen and stomach.
Summary of the invention
The present invention adopts the hepatic metastases technical scheme as follows:
A kind of colon cancer hepatic metastases Chinese medicine composition is characterized in that said composition is made up of following parts by weight hepatic metastases crude drug:
Hedyotidis Diffusae 3-9g, Rhizoma Coptidis 10-20g, Herba Scutellariae Barbatae 20-40g, Fructus Lycii 20-40g, Radix Sophorae Flavescentis 5-20g, Radix Saposhnikoviae 5-20g, Radix Bupleuri 5-20g, Rhizoma Atractylodis 20-40g, Rhizoma Atractylodis Macrocephalae 5-20g, Herba Patriniae 5-20g, Pseudobulbus Cremastrae Seu Pleiones 20-40g, Semen Cuscutae 20-40g, Herba Solani Nigri 5-20g, Cortex Fraxini 5-20g, Caulis Sargentodoxae 20-40g, Fructus Ligustri Lucidi 20-40g, Cortex Phellodendri 5-20g.
The inventor gropes through hepatic metastases repeatedly and a large amount of hepatic metastases experimental summaries go out preferred hepatic metastases Chinese medicine composition, and said composition is made up of following parts by weight hepatic metastases raw medicinal material:
Hedyotidis Diffusae 3-6g, Rhizoma Coptidis 10-15g, Herba Scutellariae Barbatae 20-30g, Fructus Lycii 20-30g, Radix Sophorae Flavescentis 5-10g, Radix Saposhnikoviae 5-10g, Radix Bupleuri 5-15g, Rhizoma Atractylodis 20-30g, Rhizoma Atractylodis Macrocephalae 5-10g, Herba Patriniae 5-10g, Pseudobulbus Cremastrae Seu Pleiones 20-30g, Semen Cuscutae 20-30g, Herba Solani Nigri 5-10g, Cortex Fraxini 5-10g, Caulis Sargentodoxae 20-30g, Fructus Ligustri Lucidi 20-30g, Cortex Phellodendri 5-10g.
Another preferred hepatic metastases Chinese medicine composition, said composition is made up of following parts by weight hepatic metastases raw medicinal material: Hedyotidis Diffusae 6g, Rhizoma Coptidis 15g, Herba Scutellariae Barbatae 30g, Fructus Lycii 30g, Radix Sophorae Flavescentis 10g, Radix Saposhnikoviae 10g, Radix Bupleuri 15g, Rhizoma Atractylodis 30g, Rhizoma Atractylodis Macrocephalae 10g, Herba Patriniae 10g, Pseudobulbus Cremastrae Seu Pleiones 30g, Semen Cuscutae 30g, Herba Solani Nigri 10g, Cortex Fraxini 10g, Caulis Sargentodoxae 30g, Fructus Ligustri Lucidi 30g, Cortex Phellodendri 10g.
Another order hepatic metastases of hepatic metastases of the present invention is to provide colon cancer Chinese medicine composition hepatic metastases preparation method, comprises the following steps:
A. extract: will according to a certain ratio Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder be become coarse powder, with Serpentis grass, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, all or part of merging of Radix Bupleuri get extract with solvent (water or 30-90% ethanol) extraction (heating or percolation) in vain.
B. purification: merge extractive liquid,, filter, filtrate is concentrated into clear paste, adds ethanol and makes and contain the alcohol amount and reach 65% and stir evenly, and leaves standstill 24 hours, filters, and decompression filtrate recycling ethanol also is concentrated into clear paste.
The present invention also can be as required with Serpentis grass 6g, Rhizoma Coptidis 15g, Herba Scutellariae Barbatae 30g, Fructus Lycii 30g, Radix Sophorae Flavescentis 10g, Radix Saposhnikoviae 10g, Radix Bupleuri 10g, Rhizoma Atractylodis 30g, Rhizoma Atractylodis Macrocephalae 10g, Herba Patriniae 10g, Pseudobulbus Cremastrae Seu Pleiones 30g, Semen Cuscutae 30g, Herba Solani Nigri 10g, Cortex Fraxini 10g, Caulis Sargentodoxae 30g, Fructus Ligustri Lucidi 30g, Cortex Phellodendri 10g in vain, directly powder becomes coarse powder, add pharmaceutic adjuvant, for example: carboxymethyl starch sodium, microcrystalline Cellulose, lactose, citric acid, micropowder silica gel, magnesium stearate, Pulvis Talci fully mixes makes granule, and compacting in flakes.
Concrete operations are as follows:
(1) Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder become coarse powder, with Serpentis grass, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri merge in vain, decoct with water twice, for the first time add 10 times in water, fried in shallow oil 2 hours, add 8 times in water for the second time, fried in shallow oil 1.5 hours, collecting decoction filters, filtrate be concentrated into relative density be 1.10-1.25 (60 ℃) hepatic metastases clear paste or.
(2) with Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder becomes coarse powder, with Serpentis grass in vain, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri merges, decoct with water twice, add for the first time 10 times in water, fried in shallow oil 2 hours, add for the second time 8 times in water, fried in shallow oil 1.5 hours, collecting decoction filters, it is 1.18-1.23 (60 ℃) hepatic metastases clear paste that filtrate is concentrated into relative density, add ethanol and make and contain alcohol amount and reach 65%, stir evenly, left standstill 24 hours, filter decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10-1.25 (60 ℃) hepatic metastases clear paste.
(3) Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder are become coarse powder, with Serpentis grass, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri merge in vain, add twice of 60% alcohol reflux, 10 times of amounts heated 2 hours for the first time, added 8 times of amounts for the second time, heated 1.5 hours, merge extractive liquid, filters, and it is 1.10-1.25 (60 ℃) hepatic metastases clear paste that filtrate is concentrated into relative density.Make oral liquid.
Can adopt water or ethanol 30-90% in the hepatic metastases preparation method of the present invention is extraction solvent, and extracting solution concentrates again, makes tablet, hard capsule, soft capsule, oral liquid, granule, honeyed pill, the watered pill, drop pill, unguentum behind the purification.
The present invention selects Serpentis grass in vain for use, and sweet little bitter temperature is returned liver stomach warp, promoting blood flow and remove blood stasis and stop bleeding.Make the liver heat removing and eyesight improving sheet, invigorate blood circulation and not absurd row, hemostasis and do not stay Currency.Rhizoma Coptidis, hardship is slightly cold, and returns Liver Channel, and the clearing away heat and cooling blood blood stasis dispelling is arranged, removing heat from blood and promoting blood circulation hepatic metastases effect.Radix Sophorae Flavescentis, Gan Xinwen returns liver heart spleen channel, the merit that having enriches blood invigorates blood circulation.Three medicine blood circulation promoting and blood stasis dispelling, heat clearing away nourish blood and are monarch drug." liver opening at eye ", retinal hemorrhage cause the optical fundus blood stasis, and blood stasis causes retention of water-damp.Radix Bupleuri, toil is slightly cold, and goes into Liver Channel, dispersing the stagnated live-QI to relieve the stagnation of QI.Herba Solani Nigri, Cortex Fraxini, the dispelling wind improving acuity of vision and removing nebula.Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, spleen invigorating dehumidifies as a means of the source of vital function.Herba Patriniae, the Caulis Sargentodoxae clearing away heat and promoting diuresis, detumescence makes eye bright.So with Radix Bupleuri, Herba Solani Nigri, Cortex Fraxini, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Herba Patriniae, Caulis Sargentodoxae is ministerial drug.Fructus Ligustri Lucidi, Semen Cuscutae, Fructus Lycii, Pseudobulbus Cremastrae Seu Pleiones are taken a tonic or nourishing food to build up one's health Liver and kidney, and replenishing vital essence to improve eyesight is an adjuvant drug.Cortex Phellodendri, Radix Saposhnikoviae medicine carrying come-up, and can win and wet is joined the Radix Bupleuri priming disease messenger drug of doing that goes directly.The application of medicine-feeding compatibility, hemorrhage ending, blood stasis looses, and taste are strong, change source foot, Liver and kidney fills, and is total to the merit of tool blood circulation promoting and blood stasis dispelling, liver heat removing improving kidney and eyes, with the treatment diabetes class eyeground haemorrhage.Can use this product behind the retinal hemorrhage.More early curative effect is good more to use this product behind the retinal hemorrhage, and it is fast more to take effect.
The specific embodiment
Below in conjunction with preferred embodiment, the present invention is done further hepatic metastases describe, being described in detail as follows according to the invention provides the hepatic metastases specific embodiment; For simple and know the hepatic metastases of hepatic metastases order, hereinafter appropriate hepatic metastases has been omitted the known technology hepatic metastases and has been described, in order to avoid those unnecessary hepatic metastases details influences are described the technical program hepatic metastases.Among the hepatic metastases embodiment of the present invention, used hepatic metastases ethanol and adjuvant are pharmaceutical grade.
Embodiment 1
Hedyotidis Diffusae 6g, Rhizoma Coptidis 15g, Herba Scutellariae Barbatae 30g, Fructus Lycii 30g, Radix Sophorae Flavescentis 10g, Radix Saposhnikoviae 10g, Radix Bupleuri 10g, Rhizoma Atractylodis 30g, Rhizoma Atractylodis Macrocephalae 10g, Herba Patriniae 10g, Pseudobulbus Cremastrae Seu Pleiones 30g, Semen Cuscutae 30g, Herba Solani Nigri 10g, Cortex Fraxini 10g, Caulis Sargentodoxae 30g, Fructus Ligustri Lucidi 30g, Cortex Phellodendri 10g.
More than 17 the flavor, get Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder and become coarse powder, merge with Hedyotidis Diffusae, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri, decoct with water twice, add 10 times in water for the first time, fried in shallow oil 2 hours, for the second time add 8 times in water, fried in shallow oil collecting decoction 1.5 hours, filter, it is 1.10-1.25 (60 ℃) hepatic metastases clear paste that filtrate is concentrated into relative density.Get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, add carboxymethyl starch sodium 50g microcrystalline Cellulose 45g, lactose 35g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 3g, Pulvis Talci 10g fully mixes and makes granule, at 40-70 ℃ of dry 2-6 hour, be pressed into 1000.
Usage and consumption: every day three times, each 8, every effective ingredient 0.31g.
Embodiment 2
Hedyotidis Diffusae 4g, Rhizoma Coptidis 12g, Herba Scutellariae Barbatae 20g, Fructus Lycii 20g, Radix Sophorae Flavescentis 8g, Radix Saposhnikoviae 8g, Radix Bupleuri 10g, Rhizoma Atractylodis 20g, Rhizoma Atractylodis Macrocephalae 10g, Herba Patriniae 10g, Pseudobulbus Cremastrae Seu Pleiones 20g, Semen Cuscutae 30g, Herba Solani Nigri 10g, Cortex Fraxini 10g, Caulis Sargentodoxae 20g, Fructus Ligustri Lucidi 30g, Cortex Phellodendri 10g.
More than 17 the flavor, get Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder becomes coarse powder, with Hedyotidis Diffusae, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri merges, decoct with water twice, add for the first time 10 times in water, fried in shallow oil 2 hours, and added 8 times in water for the second time, fried in shallow oil 1.5 hours, collecting decoction, filter, it is 1.18-1.23 (60 ℃) hepatic metastases clear paste that filtrate is concentrated into relative density, adds ethanol and makes and contain the alcohol amount and reach 65%, stir evenly, left standstill 24 hours, and filtered, decompression filtrate recycling ethanol and to be concentrated into relative density be 1.10-1.25 (60 ℃) hepatic metastases clear paste.Get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, add carboxymethyl starch sodium 45g microcrystalline Cellulose 40g, lactose 35g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 3g, Pulvis Talci 10g fully mixes and makes granule, at 40-70 ℃ of dry 2-6 hour, be pressed into 1000.Every day three times, each 8, every effective ingredient 0.25g.
Embodiment 3
Hedyotidis Diffusae 3g, Rhizoma Coptidis 15g, Herba Scutellariae Barbatae 20g, Fructus Lycii 30g, Radix Sophorae Flavescentis 10g, Radix Saposhnikoviae 10g, Radix Bupleuri 10g, Rhizoma Atractylodis 20-g, Rhizoma Atractylodis Macrocephalae 10g, Herba Patriniae 10g, Pseudobulbus Cremastrae Seu Pleiones 30g, Semen Cuscutae 30g, Herba Solani Nigri 8g, Cortex Fraxini 10g, Caulis Sargentodoxae 20g, Fructus Ligustri Lucidi 30g, Cortex Phellodendri 10g.
More than 17 the flavor, get Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder and become coarse powder, merge with Hedyotidis Diffusae, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri, add 60% alcohol reflux twice, for the first time 10 times of amounts, heated 2 hours, for the second time add 8 times of amounts, heated merge extractive liquid, 1.5 hours, filter, it is 1.10-1.25 (60 ℃) hepatic metastases clear paste that filtrate is concentrated into relative density.Get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, add carboxymethyl starch sodium 45g microcrystalline Cellulose 30g, lactose 35g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 3g, Pulvis Talci 10g fully mixes and makes granule, at 40-70 ℃ of dry 2-6 hour, be pressed into 1000.
Embodiment 4
Hedyotidis Diffusae 9g, Rhizoma Coptidis 20g, Herba Scutellariae Barbatae 30g, Fructus Lycii 20g, Radix Sophorae Flavescentis 10g Radix Saposhnikoviae 10g, Radix Bupleuri 10g, Rhizoma Atractylodis 30g, Rhizoma Atractylodis Macrocephalae 20g, Herba Patriniae 20g, Pseudobulbus Cremastrae Seu Pleiones 24g, Semen Cuscutae 20g, Herba Solani Nigri 20g, Cortex Fraxini 10g, Caulis Sargentodoxae 40g, Fructus Ligustri Lucidi 20g, Cortex Phellodendri 10g.
More than 17 the flavor, get that Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder become coarse powder and Serpentis grass, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Coptidis, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Phellodendri, Radix Saposhnikoviae, Radix Bupleuri merge in vain, add 60% alcohol reflux, alcohol adding amount is 8 times for the first time, 2 hours, alcohol adding amount is 6 times for the second time, 1.5 hour, merge extractive liquid, filters, filtrate is concentrated into relative density and is 1.10-1.25 (60 ℃) hepatic metastases clear paste, and is standby; Herba Scutellariae Barbatae, Fructus Lycii, Cortex Fraxini, Caulis Sargentodoxae are decocted with water twice, add 10 times in water for the first time, fried in shallow oil 2 hours, add 8 times in water for the second time, fried in shallow oil 1.5 hours, collecting decoction filters, and filtrate is concentrated into relative density and is 1.10-1.25 (60 ℃) hepatic metastases clear paste, and is standby; Merge two kinds of clear paste.Get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, add carboxymethyl starch sodium 40g microcrystalline Cellulose 35g, lactose 30g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 4g, Pulvis Talci 10g fully mixes and makes granule, at 40-70 ℃ of dry 2-6 hour, be pressed into 1000.Every day three times, each 8, every effective ingredient 0.32g.
Embodiment 5
Embodiment 5 hepatic metastases prescriptions and extraction process are identical with embodiment 1 hepatic metastases, get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder, add carboxymethyl starch sodium 50g microcrystalline Cellulose 45g by the configuration total amount, lactose 35g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 3g, Pulvis Talci 10g, fully mix and make granule,, be filled into then in the hungry area shell at 40-70 ℃ of dry 2-6 hour.
Embodiment 6
Embodiment 6 hepatic metastases prescriptions and extraction process are identical with embodiment 2 hepatic metastasess, get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder, add carboxymethyl starch sodium 45g microcrystalline Cellulose 40g by the configuration total amount, lactose 35g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 3g, Pulvis Talci 10g, fully mix and make granule,, be filled into then in the hungry area shell at 40-70 ℃ of dry 2-6 hour.
Embodiment 7
Embodiment 7 hepatic metastases prescriptions and extraction process are identical with embodiment 3 hepatic metastasess, get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, add carboxymethyl starch sodium 45g microcrystalline Cellulose 30g, lactose 35g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 3g, Pulvis Talci 10g, fully mix and make granule, at 40-70 ℃ of dry 2-6 hour.
Embodiment 8
Embodiment 8 hepatic metastases prescriptions and extraction process are identical with embodiment 4 hepatic metastasess, get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, add carboxymethyl starch sodium 40g microcrystalline Cellulose 35g, lactose 30g, citric acid 3g, micropowder silica gel 8g, magnesium stearate 4g, Pulvis Talci 10g, fully mix and make granule, at 40-70 ℃ of dry 2-6 hour.
Embodiment 9
Embodiment 9 hepatic metastases prescriptions and extraction process are identical with embodiment 4 hepatic metastasess, get the extract clear paste, carry out drying (60 ℃), pulverize, take by weighing extract dry powder by the configuration total amount, 100g dry powder adds Macrogol 4000 100g, polyethylene glycol 6000 100g, sodium pyrosulfite 5g, heating and melting temperature (40-90 ℃), make raw material and adjuvant fully miscible, drip and make ball.
Embodiment 10
Hepatic metastases prescription and extraction process are identical with embodiment 4 hepatic metastasess, get the extract clear paste, and 100g adds entry 1000ml, and sodium benzoate 5g stirred evenly the static placement in back after 12 hours, filtered, and oral liquid is made in the filtrate fill.
Claims (4)
1. treatment colon cancer hepatic metastases Chinese medicine composition is characterized in that said composition is made up of following parts by weight hepatic metastases crude drug:
Hedyotidis Diffusae 3-9g, Rhizoma Coptidis 10-20g, Herba Scutellariae Barbatae 20-40g, Fructus Lycii 20-40g, Radix Sophorae Flavescentis 5-20g, Radix Saposhnikoviae 5-20g, Radix Bupleuri 5-20g, Rhizoma Atractylodis 20-40g, Rhizoma Atractylodis Macrocephalae 5-20g, Herba Patriniae 5-20g, Pseudobulbus Cremastrae Seu Pleiones 20-40g, Semen Cuscutae 20-40g, Herba Solani Nigri 5-20g, Cortex Fraxini 5-20g, Caulis Sargentodoxae 20-40g, Fructus Ligustri Lucidi 20-40g, Cortex Phellodendri 5-20g.
2. hepatic metastases Chinese medicine composition according to claim 1, said composition is made up of following parts by weight hepatic metastases crude drug:
Hedyotidis Diffusae 3-6g, Rhizoma Coptidis 10-15g, Herba Scutellariae Barbatae 20-30g, Fructus Lycii 20-30g, Radix Sophorae Flavescentis 5-10g, Radix Saposhnikoviae 5-10g, Radix Bupleuri 5-15g, Rhizoma Atractylodis 20-30g, Rhizoma Atractylodis Macrocephalae 5-10g, Herba Patriniae 5-10g, Pseudobulbus Cremastrae Seu Pleiones 20-30g, Semen Cuscutae 20-30g, Herba Solani Nigri 5-10g, Cortex Fraxini 5-10g, Caulis Sargentodoxae 20-30g, Fructus Ligustri Lucidi 20-30g, Cortex Phellodendri 5-10g.
3. hepatic metastases Chinese medicine composition according to claim 1, said composition is made up of following parts by weight hepatic metastases crude drug:
Hedyotidis Diffusae 6g, Rhizoma Coptidis 15g, Herba Scutellariae Barbatae 30g, Fructus Lycii 30g, Radix Sophorae Flavescentis 10g, Radix Saposhnikoviae 10g, Radix Bupleuri 15g, Rhizoma Atractylodis 30g, Rhizoma Atractylodis Macrocephalae 10g, Herba Patriniae 10g, Pseudobulbus Cremastrae Seu Pleiones 30g, Semen Cuscutae 30g, Herba Solani Nigri 10g, Cortex Fraxini 10g, Caulis Sargentodoxae 30g, Fructus Ligustri Lucidi 30g, Cortex Phellodendri 10g.
4. one kind prepares the described Chinese medicine composition hepatic metastases of claim 1 preparation method, comprises the steps: extract hepatic metastases preparation:
A. extract: Herba Patriniae, Fructus Ligustri Lucidi, Pseudobulbus Cremastrae Seu Pleiones, Semen Cuscutae powder are become coarse powder and Serpentis grass, Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Caulis Sargentodoxae, Rhizoma Coptidis, Herba Scutellariae Barbatae, Fructus Lycii, Radix Sophorae Flavescentis, Herba Solani Nigri, Cortex Fraxini, Cortex Phellodendri, Radix Saposhnikoviae, all or part of merging of Radix Bupleuri in vain, water or 30-90% ethanol heating extraction or percolation get extract;
B. purification: merge extractive liquid,, filter, filtrate is concentrated into clear paste, adds ethanol and makes and contain the alcohol amount and reach 65% and stir evenly, and leaves standstill 24 hours, filters, and decompression filtrate recycling ethanol also is concentrated into clear paste and makes various preparations.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390013A (en) * | 2016-09-28 | 2017-02-15 | 江苏省中医院 | Compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases as well as preparation method and application thereof |
| CN107890527A (en) * | 2017-11-27 | 2018-04-10 | 扬州大学 | A kind of preparation method for the Chinese medicine compound prescription micropill for intervening intestinal cancer hepatic metastases |
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2009
- 2009-11-16 CN CN 200910228271 patent/CN102058778A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106390013A (en) * | 2016-09-28 | 2017-02-15 | 江苏省中医院 | Compound traditional Chinese medicine composition capable of inhibiting colorectal liver metastases as well as preparation method and application thereof |
| CN107890527A (en) * | 2017-11-27 | 2018-04-10 | 扬州大学 | A kind of preparation method for the Chinese medicine compound prescription micropill for intervening intestinal cancer hepatic metastases |
| CN107890527B (en) * | 2017-11-27 | 2020-12-08 | 扬州大学 | Preparation method of traditional Chinese medicine compound pellet for intervening intestinal cancer liver metastasis |
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Application publication date: 20110518 |