CN102019040A - Biofeedback photoelectric therapeutic device - Google Patents
Biofeedback photoelectric therapeutic device Download PDFInfo
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- CN102019040A CN102019040A CN 201010565204 CN201010565204A CN102019040A CN 102019040 A CN102019040 A CN 102019040A CN 201010565204 CN201010565204 CN 201010565204 CN 201010565204 A CN201010565204 A CN 201010565204A CN 102019040 A CN102019040 A CN 102019040A
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Abstract
The invention relates to a biofeedback photoelectric therapeutic device comprising an information collection system, a control system and a biofeedback therapeutic system, wherein the information collection system is used for collecting physiologic information of a human cranial part in real time and transferring the physiologic information to the control system for analysis treatment; and the control system is used for controlling the biofeedback therapeutic system according to an analysis treatment result of the physiologic information to carry out the photoelectric stimulation therapy of corresponding nervous system diseases. The biofeedback photoelectric therapeutic device is used for measuring biological, chemical or physical signals of related tissues, particularly focal tissues through the information collection system, and the biofeedback therapeutic system is used for adopting corresponding therapeutic measures according to detected signal data. The invention has specificity, selectivity, stronger purposive property and safer and effective therapy.
Description
[technical field]
The present invention relates to medical instruments field, relate in particular to the therapy equipment of a kind of biofeedback photoelectricity.
[background technology]
Continuous quickening along with rhythm of life, people generally are faced with all societies, environment and operating pressure, body and mind often is in highly tired, nervous state, many factors that jeopardize Mental Health increase thereupon, make have a depression, nervous system disease showed increased such as epilepsy.In addition, along with global population gradually to the aging transition, neurodegenerative diseases increases and becomes great society burden gradually.
The nervous system disease sickness rate increases gradually, has not only brought unlimited misery to patient, has also caused huge burden to society.Treat nervous system disease traditionally and adopt medicine and the bonded method of surgical operation more.Yet it is bigger to patient's side effect to take medicine for a long time, and since people at present to the limitation of brain and neuro-cognitive, surgical operation is careless slightly just may to cause unpredictable consequence.
In the last few years, neuroregulation treatment at treatment parkinson disease, depression, intractable pain, tremble, be rapidly developed in the application of diseases such as epilepsy and apoplexy, as repetitive transcranial magnetic stimulation, through cranium stimulus of direct current and dark electrical brain stimulation etc.
Repetitive transcranial magnetic stimulation by coil, can form a vertiginous magnetic pulse with current impulse by coil being placed on the scalp top of patient's brain stimulation target spot below coil.This magnetic pulse can have no to pass patient's skull with hindering, and brings out at patient's brain and enough to make the unpolarized electric current of neuron.
Through the cranium stimulus of direct current is a kind of by placement surface electrode on scalp, and gives the method that head is treated with the electricity irritation of gentleness.Electrode is placed on the scalp that stimulates target spot respectively and on the forehead above the eye socket of offside, causes the active change of neuron spontaneous discharge and N-acetyl-active change of D-aspartate receptor to play a role by regulating neuronic resting membrane electric potential.
Dark electrical brain stimulation be a kind of under the prerequisite of not destroying nervous tissue by regulating the method that nerve is treated, come stimulation target nervous tissue by current impulse, to adjust or to recover function of nervous system, relief of symptoms with certain intensity.
Yet all there is significant disadvantages in above-mentioned several technology, have seriously limited their use.Because magnetic field intensity is along with the very fast decay of increase of distance, therefore, for repetitive transcranial magnetic stimulation, the electric current that brings out mainly only concentrates on cortex.Simultaneously, owing to there is a spreading effect, rate is all very limited respectively through time of cranium stimulus of direct current and space.Though dark electrical brain stimulation has certain therapeutic effect, but also there are many deficiencies: at first, dark electrical brain stimulation lacks selectivity and specificity, and it is also indeterminate for the mechanism of treatment in many cases, therefore, in the process that stimulates, certain unpredictability is arranged, even may have side effects.Secondly, stimulating apparatus is after long-term the implantation, because the wound of operation and the biocompatibility issues of embedded material tend to cause inflammatory reaction, along with the formation of astrocyte encapsulation, the impedance meeting of electrode interface obviously increases, and effect of stimulation significantly weakens.In addition, encapsulation also can influence the neurocyte survival of electrode perimeter, has increased the distance of electrode and target nerve unit, and then has had a strong impact on the therapeutic effect of dark electrical brain stimulation.In addition, dark electrical brain stimulation is difficult realizes neuronic inhibition.
[summary of the invention]
Based on this, be necessary to provide a kind of biofeedback photoelectricity therapy equipment of safer effective treatment nervous system disease.
The therapy equipment of a kind of biofeedback photoelectricity comprises information acquisition system, control system and biological feedback treatment system; Information acquisition system is gathered the physiologic information of human body cranium portion in real time and physiologic information is passed to control system carry out analyzing and processing, and control system is according to the photoelectricity stimulation therapy that the analysis processing result control biological feedback treatment system of physiologic information is carried out corresponding nervous system disease; Wherein, information acquisition system comprises the chemical sensor of the electrical signal collection system that is used for gathering the lesions position signal of telecommunication, the light signal collection system that is used to gather the neuron physiological signal that has imported the photaesthesia gene, the pH that is used to gather lesions position, oxygen content or temperature data and is used to detect biosensor at least a of lesions position enzyme concentration, gene order or dopamine concentration data; Biological feedback treatment system comprises and is used for the neuron that has imported the photaesthesia gene is carried out the photostimulation therapy system of photostimulation treatment and is used for lesions position is carried out electronic stimulation system at least a of electric current or potential pulse stimulation therapy.
Preferably, also comprise light source and optoelectronic pole, optoelectronic pole comprises optical fiber and electrode, electrical signal collection system and light signal collection system are by the corresponding physiological signal of optoelectronic pole collection, and the laser that the photostimulation therapy system is sent light source is deep in the skull by optical fiber the neuron that has imported the photaesthesia gene is carried out the photostimulation treatment; The electronic stimulation system carries out electric current or potential pulse stimulation therapy by the electrode pair lesions position.
Preferably, electrode comprises reference electrode and is used to gather the lesions position EEG signals or is used for the working electrode of electricity irritation lesions position.
Preferably, working electrode surface is modified with chemical group or biomaterial, constitutes chemical sensor or biosensor with reference electrode.
Preferably, electrode comprises the insulating barrier of electrode cores and parcel electrode cores, and electrode cores one end exposes outside insulating barrier, and the other end links to each other with information acquisition system and biological feedback treatment system.
Preferably, the material of electrode cores is selected from least a in metal, metallic compound, material with carbon element and the conducting polymer; The material of insulating barrier is selected from and reaches at least a of polyimides in silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, the Parylene.
Preferably, a plurality of electrode cores distribute around the axis of optical fiber, and insulating barrier parcel electrode cores and optical fiber form the optoelectronic pole of column.
Preferably, electrode cores is the loop configuration of parcel optical fiber, and the ring width of annular electro pole piece is less than 200 μ m.
Preferably, biological feedback treatment system also comprises drug sustained release system, and drug sustained release system is used for target site is discharged photaesthesia gene, the anti-inflammatory factor, neurotrophic factor or angiogenesis factor.
Preferably, drug sustained release system comprises conduit, Teat pipette and controller, controller is used to control opening and cutting out of Teat pipette, Teat pipette transmits medicine by conduit, wherein, conduit is silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, Parylene, polyimides, metal, metallic compound, material with carbon element or conducting polymer material.
Preferably, reference electrode is a conduit, and conduit is metal, metallic compound, material with carbon element or conducting polymer material.
Preferably, optoelectronic pole is contained in catheter interior.
Preferably, electrode is plate-like, ring-type, column or taper.
Preferably, also comprise computer system, computer system is carried out further analyzing and processing and analysis processing result is sent to control system the physiologic information of gathering, and control system is carried out the photoelectricity stimulation therapy of corresponding nervous system disease according to the analysis processing result control biological feedback treatment system of computer system.
Preferably, also comprise the power-supply system that is used for to information acquisition system, control system and biological feedback treatment system power supply, power-supply system is at least a in one-shot battery, secondary cell, biological fuel cell and the radio frequency powered device.
Above-mentioned biofeedback therapy device by information acquisition system to linked groups, especially lesion tissue is carried out the measurement of biology, chemistry or physical signalling, biological feedback treatment system is taked the corresponding treatment measure according to the signal data that detects again, has specificity and selectivity.As, the photostimulation therapy system is to having imported the neuronic stimulation of photaesthesia gene, and this photaesthesia neuron only produces reaction to the photostimulation of specific wavelength, under at blue light illumination, cell membrane depolarization, cell excitement; Under the sodium yellow irradiation, the cell membrane hyperpolarization, cell excitement is suppressed, thereby further influences the metabolic activity of cell.Because be specificity and optionally detection treatment, purposiveness is stronger, and is safer and more effective.
[description of drawings]
Fig. 1 is the module diagram of an embodiment biofeedback photoelectricity therapy equipment;
Fig. 2 is the work wave sketch map of impedance transducer;
Fig. 3 is the optoelectronic pole structural representation of embodiment 1;
Fig. 4 is the optoelectronic pole structural representation of embodiment 2;
Fig. 5 is that the optoelectronic pole of embodiment 2 and the position of conduit concern sketch map;
Fig. 6 is that the optoelectronic pole of embodiment 3 and the position of conduit concern sketch map;
Fig. 7 is that the position of the optoelectronic pole of embodiment 4 and conduit, pick off concerns sketch map;
Fig. 8 is the optoelectronic pole structural representation of embodiment 5;
The sketch map that Fig. 9 uses on human body for the optoelectronic pole array.
[specific embodiment]
Therapy equipment is described in further detail to biofeedback photoelectricity mainly to reach specific embodiment below in conjunction with the accompanying drawings.
As shown in Figure 1, the biofeedback photoelectricity therapy equipment 100 of an embodiment comprises: information acquisition system 110, control system 120 and biological feedback treatment system 130.Information acquisition system 110 is gathered the physiologic information of human body cranium portion in real time and physiologic information is passed to control system 120 carry out analyzing and processing, and control system 120 is according to the photoelectricity stimulation therapy that the analysis processing result control biological feedback treatment system 130 of physiologic information is carried out corresponding nervous system disease.
Electrical signal collection system 112 is used to gather and analyze the signal of telecommunication of lesions position, comprises the EEG signals measuring instrument that is used to measure the lesions position EEG signals, the impedance transducer of measurement target tissue impedance information etc.For nervous system disease, has very strong directive significance as the treatment of epilepsy etc.When patient's brain wave occurs when unusual, electrical signal collection system 112 can feed back to control system 120 to information rapidly, in time adjusts therapeutic modality.
The impedance measurement pick off is used to measure the impedance variation of biofeedback photoelectricity therapy equipment 100 surrounding tissues, thereby can reflect the inflammatory encapsulation growing state of biofeedback photoelectricity therapy equipment 100 surrounding tissues indirectly, is convenient in time carry out the anti-inflammatory treatment.Fig. 2 is the work wave sketch map (I is a current value, and E is a potential value, and t is the time) of impedance transducer, comprises galvanism waveform 301 and potential response waveform 302.When organizing, just can obtain corresponding potential response waveform with the current impulse stimulation target of characteristic frequency.According to the ratio of current potential and electric current, just can obtain corresponding resistance value.Because the impedance of destination organization is relevant with inflammatory encapsulation situation, therefore can judge inflammatory encapsulation situation, so that in time carry out the specific aim treatment by the impedance value that this impedance transducer obtains.
Light signal collection system 114 is used to gather and analyze the neuron situation that has imported the photaesthesia gene, the stimulated luminescence of receiving target cell, thus realize the high specific of destination organization is detected or treatment.
Biological feedback treatment system 130 is mainly used in implements physical stimulation to destination organization, as photostimulation or electricity irritation etc.Biological feedback treatment system 130 comprises at least a in photostimulation therapy system 132, the electronic stimulation system 134.
In addition, biological feedback treatment system 130 also comprises drug sustained release system 136.Drug sustained release system 136 comprises conduit, Teat pipette and controller.Controller is used to control opening and cutting out of Teat pipette.Teat pipette transmits medicine by conduit.Wherein, conduit is silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, Parylene, polyimides, metal, metallic compound, material with carbon element or conducting polymer material.Drug sustained release system 136 can discharge medicines such as the anti-inflammatory factor, neurotrophic factor, angiogenesis factor by conduit to destination organization.
Preferably, before carrying out photostimulation treatment, at first need to discharge the photaesthesia gene and be transferred in the neuron with associated loop to lesions position to express, cause the excited of target nerve unit by photostimulation then or suppress by drug sustained release system 136.In therapeutic process, because the wound of operation and the biocompatibility issues of embedded material tend to cause inflammatory reaction, cause the formation of astrocyte encapsulation and the death of peripheral nerve unit, this can have a strong impact on the effect of electronic stimulation and photostimulation treatment.When inflammatory reaction produced, corresponding variation will take place in the physiological signal that information acquisition system 110 detects, and signal acquiring system 110 passes to control system 120 with the physiological signal parameter that detects; 120 pairs of these parameters of control system are analyzed the back and are produced biofeedback, and control drug sustained release system 136 carries out the release of the anti-inflammatory factor to alleviate inflammatory.In addition, in therapeutic process, also the release that can carry out neurotrophic factor according to the physiological parameter that information acquisition system 110 detects is to promote neural growth and activity, and the release of perhaps carrying out angiogenesis factor promotes the reparation of lesion tissue to strengthen the microcirculation of lesion tissue.
In biofeedback photoelectricity therapy equipment 100, the detection of information acquisition system 110 is based on that light source and optoelectronic pole carry out.Optoelectronic pole comprises optical fiber and electrode.Electrical signal collection system 112 and light signal collection system 114 are by the corresponding physiological signal of optoelectronic pole collection.The laser that photostimulation therapy system 132 is sent light source is deep in the skull by optical fiber the neuron that has imported the photaesthesia gene is carried out the photostimulation treatment.Electronic stimulation system 134 carries out electric current or potential pulse stimulation therapy by the electrode pair lesions position.
Electrode comprises reference electrode and is used to gather the lesions position EEG signals and is used for the working electrode of electricity irritation lesions position.The surface of working electrode can be modified with chemical group or biomaterial, constitutes corresponding chemical sensor 116 or biosensor 118 with reference electrode.As the working electrode behind the finishing glucoseoxidase, can constitute glucose sensor with reference electrode, be used for detecting electrode local blood sugar concentration on every side; Working electrode behind the finishing tryrosinase can constitute the dopamine pick off with reference electrode, is used for detecting electrode dopamine concentration on every side, for treatment provides foundation.
Electrode comprises the insulating barrier of electrode cores and parcel electrode cores, and electrode cores one end exposes outside insulating barrier, and the other end links to each other with information acquisition system and biological feedback treatment system.The material of electrode cores can be selected from least a in metal, metallic compound, material with carbon element, the conducting polymer.The material of insulating barrier can be selected from silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, the Parylene, polyimides at least a.Biofeedback photoelectricity therapy equipment 100 comprises an optoelectronic pole at least, when optoelectronic pole quantity is 1, constitutes the one pole optoelectronic pole, when a plurality of optoelectronic pole, constitutes the optoelectronic pole array.Optoelectronic pole can adopt multiple structure, specifically states embodiment as follows:
Embodiment 1
As shown in Figure 3, comprise 3 working electrodes and 1 reference electrode in the optoelectronic pole 200 of present embodiment.The electrode cores 220 (to call reference electrode core 220 in the following text) of electrode cores 210 of working electrode (to call working electrode core 210 in the following text) and reference electrode is a metal fibril.Working electrode core 210 and reference electrode core 220 are around the surface distributed of optical fiber 230, and the distance between electrode cores (comprising working electrode core 210 and reference electrode core 220) and the optical fiber 230 is 0-1mm.Insulating barrier 240 parcel working electrode cores 210, reference electrode core 220 and optical fiber 230, the optoelectronic pole 200 of formation column.
The material of the working electrode core 210 of present embodiment is a yttrium oxide, and the material of reference electrode core 220 is silver/silver chloride, and the two constitutes iridium oxide electrode and silver/silver chloride electrode.When physiologic information is gathered, iridium oxide electrode as the reference electrode, is used to write down the signal of telecommunication in focus zone as recording electrode, silver/silver chloride electrode, after the analyzing and processing of control system 120, the parameter of photostimulation and electricity irritation that upgrades in time, thus can treat more effectively.In the process of photoelectricity stimulation therapy, iridium oxide electrode as the reference electrode, cooperates optical fiber 230 can carry out the photoelectricity stimulation therapy very accurately and effectively as stimulating electrode, silver/silver chloride electrode.
Embodiment 2
As shown in Figure 4, the optoelectronic pole 300 of present embodiment comprises the annular electro pole piece 320 that optical fiber 310 reaches around optical fiber 310 surface distributed.The ring width of annular electro pole piece 320 is less than 200 μ m.Annular electro pole piece 320 is the metal microtubule or is sedimentary metal, metallic compound, material with carbon element or conducting polymer etc. around optical fiber 310.Wherein, deposition process can be by realizations such as chemical deposition, chemical vapour deposition (CVD), ion sputtering, magnetron sputtering or high temperature depositions.The skin of annular electro pole piece 320 is by insulating barrier 330 encapsulation, and an end exposes the end face of annular electro pole piece 320, forms annular electrode.This annular electro pole piece 320 directly contacts with optical fiber 310, can carry out eeg recording or photoelectricity stimulation therapy more exactly.In addition, annular electro pole piece 320 can form minute surface at the outer wall of optical fiber 310, can prevent the scattering of laser in conductive process more effectively.
Fig. 5 is the location diagram of optoelectronic pole 300 and conduit 340, and optoelectronic pole 300 is fixedlyed connected by connecting device 350 with conduit 340.Optoelectronic pole 300 and conduit 340 parallel distributions.The material of conduit 340 is selected from least a in silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, Parylene, polyimides, metal, metallic compound, material with carbon element, the conducting polymer.When the material of conduit 340 was conductor, conduit 340 conduct simultaneously was with reference to electrode; When the material of conduit 340 is non-conductor, can constitute reference electrode at the surface deposition conducting metal of conduit 340.
Embodiment 3
As shown in Figure 6, optoelectronic pole 400 sizes of present embodiment are less, and the optoelectronic pole 300 among structure and the embodiment 2 is roughly the same.Optoelectronic pole 400 is positioned at the inside of conduit 500, and optoelectronic pole 400 at one end is connected by connecting device 510 with conduit 500.With embodiment 2, the conduit 500 of present embodiment also can be used as reference electrode.Because optoelectronic pole 400 is less, can be used as the one pole optoelectronic pole of implanting the position, deep and use, can reduce the selectivity of operation wound, intensifier electrode.
Embodiment 4
As shown in Figure 7, optoelectronic pole 600 structures of present embodiment and the optoelectronic pole 300 among the embodiment 2 are roughly the same.In the present embodiment, optoelectronic pole 600 be arranged in parallel with conduit 610 and pick off 620, and the three is at one end fixedly connected by connecting device 630.Wherein, pick off 620 can be chemical sensor 116 or biosensor 118 etc.Conduit 610 can adopt conductive material, perhaps with non-conductor through deposition processes and then as the reference electrode of optoelectronic pole 600 and pick off 620.By with pick off 620 and the optoelectronic pole 600 relatively independent selectivity and the sensitivity that can strengthen pick off 620.
Embodiment 5
As shown in Figure 8, the optoelectronic pole 700 of present embodiment comprises optical fiber 710 and the electrode 720 that distributes around optical fiber 710.Electrode 720 is a microdisk electrode.The optoelectronic pole 700 of present embodiment comprises 4 electrodes 720.Electrode 720 is fixed on optical fiber 710 surfaces by encapsulating material, and the end face of the end face of electrode 720 and optical fiber 710 is in same horizontal plane, thereby has constituted four electrodes that are distributed in three dimensions that comprise optical fiber 710.The electrode 720 of four electrode structures can detect by trigonometry, therefore can improve the precision and the scope of detection greatly, and can strengthen optoelectronic pole 700 secular stable performances.
Embodiment 6
The sketch map that Fig. 9 uses on human body for optoelectronic pole array 800.Electrode 810 in the optoelectronic pole array 800 can in the foregoing description 1 to embodiment 5 any one or multiple, also can in the optical fiber, electrode, pick off and the conduit that scatter any one or multiple.Optoelectronic pole array 800 also comprises connecting device 820, fixture 830, connecting line and sleeve pipe 840.Optoelectronic pole array 800 can be deep in the cortex 860 in the skull 850, and sleeve pipe 840 whole heeling-ins are in human epidermal 870.One end link information acquisition system 110 and biological feedback treatment system 130 of sleeve pipe 840, the other end is fixed on the skull 850 by fixture 830 in human epidermal 870, and passes skull 850 (pre-aligned punching) and be deep into cortex 860.
In addition, in preferred embodiment, the power-supply system 150 that biofeedback photoelectricity therapy equipment 100 also comprises computer system 140 and is used for powering to information acquisition system 110, control system 120 and biological feedback treatment system 130.
The physiologic information of 140 pairs of collections of computer system carries out further analyzing and processing, and physiologic information exported in the mode of form, image or sound, be convenient to the doctor or the patient in time understands, result with analyzing and processing is sent to control system 120 at last, and control system 120 is carried out the photoelectricity stimulation therapy of corresponding nervous system disease according to the analysis processing result control biological feedback treatment system 130 of computer system 140.
Power-supply system 150 can be in one-shot battery, secondary cell, biological fuel cell and the radio frequency powered device at least a.When control system 120 is connected with computer system 140, can directly powers or charge by computer system 140 to power-supply system 150.
Above-mentioned biofeedback therapy device 100 is by 110 pairs of linked groups of information acquisition system, especially lesion tissue is carried out the measurement of biology, chemistry or physical signalling, biological feedback treatment system 130 is taked the corresponding treatment measure according to the signal data that detects again, has specificity and selectivity.As, 132 pairs of photostimulation therapy system have imported the neuronic stimulation of photaesthesia gene, and this photaesthesia neuron only produces reaction to the photostimulation of specific wavelength, under at blue light illumination, cell membrane depolarization, cell excitement; Under the sodium yellow irradiation, the cell membrane hyperpolarization, cell excitement is suppressed, thereby further influences the metabolic activity of cell.Because be specificity and optionally detection treatment, purposiveness is stronger, and is safer and more effective.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (15)
1. biofeedback photoelectricity therapy equipment is characterized in that, comprises information acquisition system, control system and biological feedback treatment system; Described information acquisition system is gathered the physiologic information of human body cranium portion in real time and described physiologic information is passed to described control system carry out analyzing and processing, and described control system is according to the analysis processing result of described physiologic information is controlled the photoelectricity stimulation therapy that described biological feedback treatment system carries out corresponding nervous system disease; Wherein, described information acquisition system comprises the chemical sensor of the electrical signal collection system that is used for gathering the lesions position signal of telecommunication, the light signal collection system that is used to gather the neuron physiological signal that has imported the photaesthesia gene, the pH that is used to gather lesions position, oxygen content or temperature data and is used to detect biosensor at least a of lesions position enzyme concentration, gene order or dopamine concentration data; Described biological feedback treatment system comprises and is used for the neuron that has imported the photaesthesia gene is carried out the photostimulation therapy system of photostimulation treatment and is used for lesions position is carried out electronic stimulation system at least a of electric current or potential pulse stimulation therapy.
2. biofeedback photoelectricity as claimed in claim 1 therapy equipment, it is characterized in that, also comprise light source and optoelectronic pole, described optoelectronic pole comprises optical fiber and electrode, described electrical signal collection system and described light signal collection system are by the corresponding physiological signal of described optoelectronic pole collection, and the laser that described photostimulation therapy system is sent described light source is deep in the skull by described optical fiber the neuron that has imported the photaesthesia gene is carried out the photostimulation treatment; Described electronic stimulation system carries out electric current or potential pulse stimulation therapy by described electrode pair lesions position.
3. biofeedback photoelectricity as claimed in claim 2 therapy equipment is characterized in that, described electrode comprises reference electrode and is used to gather the lesions position EEG signals or is used for the working electrode of electricity irritation lesions position.
4. biofeedback photoelectricity as claimed in claim 3 therapy equipment is characterized in that described working electrode surface is modified with chemical group or biomaterial, constitutes described chemical sensor or described biosensor with described reference electrode.
5. as claim 2 or 4 described biofeedback photoelectricity therapy equipments, it is characterized in that, described electrode comprises electrode cores and wraps up the insulating barrier of described electrode cores, described electrode cores one end exposes outside described insulating barrier, and the other end links to each other with described information acquisition system and described biological feedback treatment system.
6. biofeedback photoelectricity as claimed in claim 5 therapy equipment is characterized in that, the material of described electrode cores is selected from least a in metal, metallic compound, material with carbon element and the conducting polymer; The material of described insulating barrier is selected from and reaches at least a of polyimides in silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, the Parylene.
7. biofeedback photoelectricity as claimed in claim 5 therapy equipment is characterized in that, a plurality of described electrode cores distribute around the axis of described optical fiber, and described insulating barrier wraps up the optoelectronic pole of described electrode cores and described optical fiber formation column.
8. biofeedback photoelectricity as claimed in claim 5 therapy equipment is characterized in that, described electrode cores is the loop configuration of the described optical fiber of parcel, and the ring width of annular electro pole piece is less than 200 μ m.
9. biofeedback photoelectricity as claimed in claim 4 therapy equipment, it is characterized in that, described biological feedback treatment system also comprises drug sustained release system, and described drug sustained release system is used for target site is discharged photaesthesia gene, the anti-inflammatory factor, neurotrophic factor or angiogenesis factor.
10. biofeedback photoelectricity as claimed in claim 9 therapy equipment, it is characterized in that, described drug sustained release system comprises conduit, Teat pipette and controller, described controller is used to control opening and cutting out of described Teat pipette, described Teat pipette is by described conduit transmission medicine, wherein, described conduit is silicone rubber, glass, pottery, silicon dioxide, epoxy resin, politef, Parylene, polyimides, metal, metallic compound, material with carbon element or conducting polymer material.
11. biofeedback photoelectricity as claimed in claim 10 therapy equipment is characterized in that, described reference electrode is described conduit, and described conduit is metal, metallic compound, material with carbon element or conducting polymer material.
12. biofeedback photoelectricity as claimed in claim 10 therapy equipment is characterized in that described optoelectronic pole is contained in described catheter interior.
13. biofeedback photoelectricity as claimed in claim 2 therapy equipment is characterized in that, described electrode is plate-like, ring-type, column or taper.
14. biofeedback photoelectricity as claimed in claim 1 therapy equipment, it is characterized in that, also comprise computer system, described computer system is carried out further analyzing and processing and analysis processing result is sent to described control system the physiologic information of gathering, and described control system is controlled the photoelectricity stimulation therapy that described biological feedback treatment system carries out corresponding nervous system disease according to the analysis processing result of computer system.
15. biofeedback photoelectricity as claimed in claim 1 therapy equipment, it is characterized in that, also comprise the power-supply system that is used for to described information acquisition system, control system and biological feedback treatment system power supply, described power-supply system is at least a in one-shot battery, secondary cell, biological fuel cell and the radio frequency powered device.
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