CN110812707A - Brain imaging and light nerve regulation and control integrated device - Google Patents
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Abstract
The invention relates to a brain imaging and light nerve regulation and control integrated device, which comprises: the system comprises a near infrared spectrum imaging module, a control module and a light nerve regulation and control module; the near infrared spectrum imaging module comprises a plurality of first light sources and receivers and is used for illuminating the brain to obtain an imaging signal of the brain and transmitting the imaging signal to the control module; the control module analyzes the imaging signal and adjusts the parameters of the optical nerve regulation and control module according to the imaging signal; the light nerve regulation and control module comprises a plurality of second light sources, and the second light sources stimulate the same position of the brain according to the parameters determined by the control module; wherein the first light sources constitute a first array, the receivers constitute a second array, the first and second arrays are nested with each other, and the second light sources are disposed in the gaps between the first and second arrays. This device is through above-mentioned mode of setting up for can carry out near infrared spectrum formation of image and the regulation and control of light nerve simultaneously to the same region of brain, adjust in real time to the parameter of the regulation and control of light nerve.
Description
Technical Field
The invention relates to a brain imaging and optical nerve regulation and control integrated device, and belongs to the field of medical equipment.
Background
Light neuromodulation is a non-invasive, non-thermal neuromodulation technique for human brain using near-infrared light. Light neuromodulation is a novel form of photobiological modulation, also known as low-level light therapy, that utilizes light of specific wavelengths to safely penetrate the brain, modulating mitochondrial respiratory biological processes, leading to alterations in brain metabolism and hemodynamics, thereby promoting neuroprotection and cognitive enhancement. Meanwhile, in order to quantify the influence of the light nerve regulation on the human brain, the brain function activity can be detected by near infrared spectral brain function imaging (fNIRS). Compared with other imaging technologies, the near-infrared brain imaging method is simple to operate and can realize data acquisition under high time resolution. Near infrared spectrum brain imaging utilizes low absorption and high scattering characteristics of near infrared light when the near infrared light is transmitted in a photo-biological tissue to calculate intensity changes of incident photons and emergent photons and calculate hemoglobin concentration changes in human brain, so that brain conditions can be monitored and fed back when light nerve is regulated.
However, in the prior art, near infrared spectrum brain imaging is usually performed before or after the light nerve regulation, and a device for imaging the brain in real time in the light nerve regulation process is not provided, so that the feedback of the near infrared spectrum brain imaging on the light nerve regulation has hysteresis, and the optimal light nerve regulation parameter can be obtained by repeating the process for many times. This is because the light emitting and detecting device of the near infrared spectrum brain imaging needs to be in direct contact with the parietal skin, and the light emitting and detecting device has a large coverage area, which causes the region of the light nerve regulation and control to be different from the region of the near infrared spectrum brain imaging, and the feedback data has no referential property. The above problems are particularly serious when the test object is an infant or a child, and need to be solved.
Disclosure of Invention
In view of the above-mentioned deficiencies of the prior art, the present invention provides an integrated device for brain imaging and optical nerve modulation, which can simultaneously perform near infrared spectrum imaging and optical nerve modulation on the same region of the brain by reasonably arranging the near infrared spectrum imaging light source, the receiver and the optical nerve modulation light source position, and adjust the parameters of the optical nerve modulation in real time by the real-time feedback of the near infrared spectrum imaging.
In order to achieve the above object, the present invention provides an integrated device for brain imaging and light nerve modulation, comprising: the near infrared spectrum imaging module, the control module and the optical nerve regulation and control module are sequentially connected; the near infrared spectrum imaging module comprises a plurality of first light sources and receivers and is used for illuminating the brain to obtain an imaging signal of the brain and transmitting the imaging signal to the control module; the control module analyzes the imaging signal obtained by the near infrared spectrum imaging module and adjusts the parameters of the optical nerve regulation and control module according to the imaging signal; the light nerve regulation and control module comprises a plurality of second light sources, and the second light sources stimulate the same position of the brain detected by the near infrared spectrum imaging module according to the parameters determined by the control module; wherein the first light sources constitute a first array, the receivers constitute a second array, the first and second arrays are nested within each other, and the second light sources are arranged in the gaps between the first and second arrays.
Further, the first array can be arranged into first arrays of different shapes, which are rectangular, triangular, trapezoidal, rhombic or polygonal, according to the location of the brain to be stimulated, and the receiver is arranged in the center of the first array.
Further, the near infrared spectrum imaging module and the optical nerve regulation and control module are integrated on a flexible substrate, flexible substrates with different shapes are arranged according to different positions of the stimulated brain, and the flexible substrate is attached to the position to be detected on the top of the head; or the flexible substrate is arranged in a cap shape and worn on the head of the object to be detected for detection.
Further, the first light source and the second light source are micro LED light sources, a first array formed by a plurality of first light sources, a second array formed by a plurality of receivers and a third array formed by a plurality of second light sources are integrated on a micro LED chip.
Further, the near infrared spectrum imaging module comprises an optical signal processor, and the first light source is used for emitting near infrared light; the receiver is used for receiving near infrared transmitted light signals passing through brain tissues; the optical signal processor is used for converting the near-infrared transmission light signal into the concentrations of oxyhemoglobin and deoxyhemoglobin and calculating the brain network index according to the concentrations of oxyhemoglobin and deoxyhemoglobin.
Further, the brain network indicators include brain functional connectivity, brain network aggregation coefficients, network shortest paths, normalized clustering coefficient gamma values, standard feature path length lambda values, small world attribute value sigma values, global network efficiency, local network efficiency, and brain signal complexity.
Further, the control module comprises an optical parameter regulation and control module and a brain imaging information acquisition module, and the brain imaging information acquisition module receives an imaging signal obtained by the near infrared spectrum imaging module through the optical signal transmission module; the optical parameter regulation and control module regulates the parameters of the optical nerve regulation and control module according to the imaging signals and transmits the regulated parameters to the optical nerve regulation and control module through the optical signal transmission module.
Further, the light nerve modulation parameter includes at least one of a light wavelength, a light intensity, a light time, a light position, and a light range.
Due to the adoption of the technical scheme, the invention has the following advantages: 1. this device is through rationally arranging near infrared spectrum formation of image light source, receiver and light nerve regulation and control light source position for can carry out near infrared spectrum formation of image and light nerve regulation and control simultaneously to the same region of brain, through near infrared spectrum formation of image's real-time feedback, adjust in real time to the parameter of light nerve regulation and control. 2. According to the comparison result of the comprehensive brain network indexes and the standard value, the fact that the user is possibly suffered from diseases such as depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like is judged, and targeted light nerve regulation and control are carried out on the head of the user according to the diagnosis result, so that the effects of relieving and assisting in treatment of the diseases are achieved. 3. When the device is used by a healthy user, the brain health condition of the user can be known at any time, and the cognitive ability of the user is improved. 4. The device is integrated on the flexible substrate, the flexible substrate is arranged into a split type structure, the flexible substrate can be directly pasted on the corresponding part of the top of the head of an object to be tested, or the flexible substrate is arranged into a cap shape and worn on the top of the head of the object to be tested, the device is simple in structure and convenient to test, and the comfort level of the object to be tested is improved.
Drawings
FIG. 1 is a schematic structural diagram of an integrated brain imaging and light neuromodulation apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram illustrating an exemplary use of the integrated brain imaging and light nerve modulation device according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of the arrangement of the first light source, the receiver, and the second light source on the flexible substrate according to an embodiment of the invention.
Reference numerals:
1-a first light source; 2-a receiver; 3-a second light source.
Detailed Description
The present invention is described in detail by way of specific embodiments in order to better understand the technical direction of the present invention for those skilled in the art. It should be understood, however, that the detailed description is provided for a better understanding of the invention only and that they should not be taken as limiting the invention. In describing the present invention, it is to be understood that the terminology used is for the purpose of description only and is not intended to be indicative or implied of relative importance.
The present embodiment provides an integrated device for brain imaging and light nerve modulation, as shown in fig. 1 to 3, including: the near infrared spectrum imaging module, the control module and the optical nerve regulation and control module are sequentially connected; the near infrared spectrum imaging module comprises a plurality of first light sources 1 and receivers 2 and is used for illuminating the brain to obtain an imaging signal of the brain and transmitting the imaging signal to the control module; the control module analyzes the imaging signal obtained by the near infrared spectrum imaging module and adjusts the parameters of the optical nerve regulation and control module according to the imaging signal; the light nerve regulation and control module comprises a plurality of second light sources 3, and the second light sources 3 stimulate the same position of the brain detected by the near infrared spectrum imaging module according to the parameters determined by the control module; wherein the first light sources 1 constitute a first array, the receivers 2 constitute a second array, the first and second arrays are nested within each other, and the second light sources 3 are arranged in the gaps between the first and second arrays. The device in this embodiment is through rationally arranging near infrared spectrum formation of image light source, receiver 2 and light nerve regulation and control light source position for can carry out near infrared spectrum formation of image and light nerve regulation and control simultaneously to the same region of brain, through the real-time feedback of near infrared spectrum formation of image, adjust the parameter of light nerve regulation and control in real time. According to the comparison result of the comprehensive brain network indexes and the standard value, the fact that the user is possibly suffered from diseases such as depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like is judged, and targeted light nerve regulation and control are carried out on the head of the user according to the diagnosis result, so that the effects of relieving and assisting in treatment of the diseases are achieved.
The first array in this embodiment can be arranged into first arrays of different shapes, which can be but are not limited to rectangular, triangular, trapezoidal, diamond-shaped or polygonal, depending on the location of the brain to be stimulated, with the receiver 2 being placed in the center of the first array. As shown in fig. 3, the first light sources 1 of the frontal lobe region are arranged in a triangle, and the receiver 2 is disposed at the center of the triangle; the first light sources 1 of the top leaf area are arranged in a rectangle, and the receiver 2 is arranged at the center of the rectangle; the first light sources 1 of the occipital lobe area are arranged in a trapezoid with the receiver 2 disposed at the center of the trapezoid. The near infrared spectrum imaging module and the optical nerve regulation and control module are integrated on a flexible substrate, flexible substrates with different shapes are arranged according to different positions of the stimulated brain, and the flexible substrate in the frontal lobe area is triangular as shown in fig. 3; the flexible substrate of the top leaf area is in a diamond shape; the flexible base of the occipital lobe area is trapezoidal. When the flexible substrate is used, the flexible substrate is attached to the position to be detected on the top of the head or is arranged in a cap shape, and the flexible substrate is worn on the head of an object to be detected. The flexible substrate may be a flexible patch or a flexible band like an eyecup or a flexible head cover or cap, etc., but the type of flexible substrate is not limited thereto.
In this embodiment, the first light source 1 and the second light source 3 are micro LED light sources, and a first array composed of a plurality of first light sources 1, a second array composed of a plurality of receivers 2, and a third array composed of a plurality of second light sources 3 are integrated on a micro LED chip. Wherein the arrangement in fig. 3 is only schematically illustrated and does not mean that the area of the first light source 1 and the receiver 2 is necessarily larger than the area of the second light source 3, the first light source 1 and the second light source 3 may be an array of LEDs of the same size. When the light required for the light nerve regulation is near-infrared light, only one light source may be provided to be used as the first light source 1 and the second light source 2.
The near infrared spectrum imaging module in the embodiment comprises: a first light source 1, a receiver 2 and an optical signal processor arranged in pairs. The first light source 1 is used for emitting near infrared light; the receiver 2 is used for receiving near infrared transmitted light signals passing through brain tissues; the optical signal processor is used for converting the near-infrared transmission light signal into oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration according to a modified Beer-Lambert law; and removing motion artifacts and physiological noise from the concentration signal, and performing band-pass filtering. Then, a brain network index is calculated from the oxyhemoglobin and deoxyhemoglobin concentrations. The brain network indexes include: the brain network indexes comprise brain function connectivity, brain network aggregation coefficients, network shortest paths, normalized clustering coefficient gamma values, standard characteristic path length lambda values, small world attribute value sigma values, global network efficiency, local network efficiency and brain signal complexity. Wherein, the optical signal processor can be arranged together with the first light source 1 and the receiver 2 to facilitate the processing of the near-infrared transmission light signal; however, in order to make the near infrared spectrum imaging module more portable, the optical signal processor may not be disposed together with the first light source 1 and the receiver 2. For example, the optical signal processor may be provided in the control module. And the data of the near infrared spectrum imaging module is transmitted to the control module through the optical signal transmission module. Wherein, optical signal transmission module can include data line, data interface etc. but preferred optical signal transmission module is wireless optical signal transmission module, like WIFI, GPRS, bluetooth etc..
In the embodiment, the brain imaging module can detect the brain function before the optic nerve regulates the cranial nerves, determine the position, the intensity and other parameters of the optic nerve regulation, and simultaneously, in the whole optic nerve regulation process, the brain imaging module can also monitor the cranial nerve condition at any time, and is used for detecting whether the position, the range, the light intensity and other parameters of the optic nerve regulation are reasonable or not, whether the adjustment is needed or not, and feeding back the real-time detected information to the control module. The internal control module in the control module comprises an optical parameter regulation and control module and a brain imaging information acquisition module, and the brain imaging information acquisition module receives imaging signals obtained by the near infrared spectrum imaging module through the optical signal transmission module; the optical parameter regulation and control module regulates the parameters of the optical nerve regulation and control module according to the imaging signals and transmits the regulated parameters to the optical nerve regulation and control module through the optical signal transmission module.
The optical parameter regulation and control module receives information fed back by the near infrared spectrum imaging module, analyzes and processes the information fed back according to a preset algorithm in a program, judges whether the initially determined optical nerve regulation and control scheme is reasonable, and further optimizes parameters of the scheme if the scheme is reasonable, such as fine adjustment of parameters of illumination intensity, wavelength, area, position and the like, so as to achieve a better optical nerve regulation and control effect. If the initial light nerve regulation scheme is unreasonable, the scheme is adjusted, so that the harm to a user due to improper operation is avoided, and the safety and the accuracy of light nerve regulation are improved.
In the embodiment, the optical nerve regulation and control module regulates the illumination parameters according to the signals transmitted by the control module, is used for regulating the cranial nerves of a user and has certain auxiliary treatment effect on the cerebral diseases; it also has cognitive function improving effect for healthy users. The reason why the optic nerve control module can relieve brain diseases and improve cognitive ability is that Cytochrome C Oxidase (CCO) in human brain absorbs photons. Cytochrome c oxidase is located at the end of the cytochrome system in cellular respiration, and this enzyme transfers the electrons of the respiratory substrate directly to molecular oxygen via the cytochrome system. The light emitted from the light emitting module passes through a series of layers such as the scalp, periosteum, skull, meninges and dura mater, and finally reaches the surface of the human cerebral cortex, and is absorbed by the CCO. CCO plays a key role in brain metabolism, and the higher its activity, the higher the oxygen consumption and metabolic capacity of mitochondria. ATP, which is a high-energy compound in organisms, is mainly produced by mitochondria, is usually present inside cells, and serves as an energy currency molecule to support various metabolic activities of cells. Mitochondria are the most prominent source of intracellular ATP, determining ATP levels. Therefore, the increase of oxygen consumption and metabolism of mitochondria can lead to increase of ATP in cells, thereby promoting the growth and development of human brain cells, and the increase of ATP at a certain level can stimulate free Ca in cells2+Increase in molecular content of Nitric Oxide (NO), Reactive Oxygen Species (ROS), etc. Wherein NO binds to CCOThereby inhibiting CCO activity and reducing ATP production. The light signal absorbed by the CCO can increase ATP yield by separating NO, thereby preventing NO from binding to CCO. Therefore, the light nerve regulation can relax blood vessels of the brain, increase blood circulation, promote the brain nerve protection and enhance the brain cognitive function.
The above embodiments are only for illustrating the present invention, and the structure, size, arrangement position and shape of each component can be changed, such as the appearance size, fixing manner, lead wire manner and geometric configuration after assembly of each component.
Claims (8)
1. An integrated brain imaging and light neuromodulation device, comprising: the near infrared spectrum imaging module, the control module and the optical nerve regulation and control module are sequentially connected;
the near infrared spectrum imaging module comprises a plurality of first light sources and receivers and is used for illuminating the brain to obtain an imaging signal of the brain and transmitting the imaging signal to the control module;
the control module analyzes the imaging signal obtained by the near infrared spectrum imaging module and adjusts the parameter of the optical nerve regulation and control module according to the imaging signal;
the light nerve regulation and control module comprises a plurality of second light sources, and the second light sources stimulate the same position of the brain detected by the near infrared spectrum imaging module according to the parameters determined by the control module;
wherein the first light sources form a first array and the receivers form a second array, the first and second arrays being nested within one another, and a second light source being disposed in a gap between the first and second arrays.
2. The integrated brain imaging and light nerve modulation device according to claim 1, wherein the first array can be arranged in different shapes of rectangular, triangular, trapezoidal, rhombic or polygonal first array according to the location of the brain to be stimulated, and the receiver is disposed at the center of the first array.
3. The integrated brain imaging and light nerve modulation device according to claim 2, wherein the near infrared spectrum imaging module and the light nerve modulation module are integrated on a flexible substrate, the flexible substrates with different shapes are arranged according to the position of the stimulated brain, and the flexible substrates are attached to the position to be detected on the top of the head; or the flexible substrate is arranged in a cap shape and worn on the head of the object to be detected for detection.
4. The integrated brain imaging and light nerve modulation device according to any one of claims 1-3, wherein the first and second light sources are micro LED light sources, a first array of a plurality of the first light sources, a second array of a plurality of the receivers, and a third array of the plurality of the second light sources are integrated on a micro LED chip.
5. The integrated brain imaging and light neuromodulation device as in any of claims 1 to 3, wherein the near infrared spectroscopy imaging module comprises a light signal processor, the first light source for emitting near infrared light; the receiver is used for receiving near-infrared transmitted light signals passing through brain tissues; the optical signal processor is used for converting the near-infrared transmission optical signal into the concentrations of oxyhemoglobin and deoxyhemoglobin and calculating the brain network index according to the concentrations of oxyhemoglobin and deoxyhemoglobin.
6. The integrated brain imaging and light neuromodulation device as in claim 5, wherein the brain network metrics comprise brain functional connectivity, brain network aggregation coefficients, network shortest paths, normalized clustering coefficient γ values, standard feature path length λ values, small world attribute value σ values, global network efficiency, local network efficiency, and brain signal complexity.
7. The integrated brain imaging and optical nerve modulation device according to any one of claims 1 to 3, wherein the control module comprises an optical parameter modulation module and a brain imaging information acquisition module, and the brain imaging information acquisition module receives the imaging signals obtained by the near infrared spectrum imaging module through an optical signal transmission module; the optical parameter regulation and control module regulates the parameters of the optical nerve regulation and control module according to the imaging signals and transmits the regulated parameters to the optical nerve regulation and control module through the optical signal transmission module.
8. The integrated brain imaging and light neuromodulation device of claim 7 wherein the parameters of the light neuromodulation module include at least one of light wavelength, light intensity, light time, light location, and light range.
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