CN110801580A - Brain light stimulation regulation and control device - Google Patents
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Abstract
The invention relates to a brain light stimulation regulation and control device, which comprises: the optical parameter regulating module, the light source, the light irradiation probe and the probe position regulator are connected in sequence; the optical parameter regulation and control module is connected with the light source and is used for setting the light intensity, the wavelength and the illumination time of the optical signal generated by the light source; the light source generates an optical signal with specific light intensity and frequency and transmits the optical signal to the light irradiation probe; the illumination area of the light irradiation probe can be adjusted according to different illumination modes and is used for implementing fixed-point illumination on the area corresponding to the specific brain diseases; the probe position adjuster is connected with the light irradiation probe and is used for adjusting and locking the light irradiation position of the light irradiation probe. The invention inputs optical signals to specific parts of the human brain, increases ATP in the human brain, enhances the activity of the human brain, improves the cognitive ability of the human brain, and has certain adjuvant therapy effect on diseases such as depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like.
Description
Technical Field
The invention relates to a brain light stimulation regulation and control device, and belongs to the field of medical equipment.
Background
Cranial nerve regulation is an emerging method for improving the symptoms and quality of life of patients. At present, the more common brain nerve regulation method mainly comprises the following steps: transcranial Electrical Stimulation (TES) and Transcranial Magnetic Stimulation (TMS). The working principle is that the electrical signal or the magnetic signal is input into the brain to cause the activity potential of the neuron in the brain to change, thereby achieving the purpose of treating and improving the cognitive ability of the patient. Studies have shown that TES can play a role in improving cognitive abilities of patients such as motor control, short-term memory, problem solving and decision making; TMS can improve the cognitive ability of patients with depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like. However, TES adopts an electric signal stimulation mode, and if the electric signal parameters are not properly selected, the user is easy to cause discomfort reactions such as dizziness, nausea, headache and the like; the TMS device is bulky, expensive, and dangerous once it is not operated properly because it needs to generate a controllable magnetic field. Therefore, there is an urgent need for a cranial nerve regulation method with safety and reliability.
Because the intensity, the frequency and the illumination range of the optical signal have higher adjustability, the light signal stimulation is a safer and more reliable cranial nerve regulation scheme at present. However, the optical signal stimulation scheme in the prior art usually stimulates the whole brain, macroscopically and conceptually strengthens the brain, and improves the cognitive ability of people, namely the regulation and control of the cranial nerves by optical stimulation are concentrated in the stage of qualitative research. However, there is individual variability for each organism, and the light signals used by the general population are not necessarily suitable for a particular individual, especially for a particular individual with a certain brain disease. Therefore, it is necessary to design the corresponding optical parameters according to the specific situation of the brain of each specific user, i.e. it is necessary to quantitatively adjust the cranial nerves by using the light signals according to the specific situation of the user.
Disclosure of Invention
In view of the above-mentioned deficiencies of the prior art, an object of the present invention is to provide a brain light stimulation control device, which monitors the human brain in real time through near-infrared brain imaging and adjusts information such as intensity, wavelength, and illumination area of light signals according to the obtained brain network index, so that the light stimulation signals for brain nerve control are completely determined according to the specific conditions of the brain of a user, and the light stimulation control is more targeted.
In order to achieve the above object, the present invention provides a brain light stimulation control device, comprising: the near-infrared imaging module, the control module and the light stimulation module are connected in sequence; the near-infrared imaging module illuminates the brain to obtain the concentration of oxygenated hemoglobin and deoxygenated hemoglobin of the brain and brain network indexes, and transmits the obtained result to the control module; the control module analyzes the result obtained by the near-infrared imaging module and adjusts the parameters of the light stimulation module according to the result; the light stimulation module stimulates a specific region of the brain with parameters determined by the control module.
Further, the near-infrared imaging module comprises a near-infrared light emitter, a near-infrared light receiver and an optical signal processor which are arranged in pairs, wherein the near-infrared light emitter is used for emitting near-infrared light; the near-infrared light receiver is used for receiving a near-infrared transmitted light signal passing through brain tissue; the optical signal processor is used for converting the near-infrared transmission light signal into the concentrations of oxyhemoglobin and deoxyhemoglobin and calculating the brain network index according to the concentrations of oxyhemoglobin and deoxyhemoglobin.
Further, the brain network indicators include brain functional connectivity, brain network aggregation coefficients, network shortest paths, normalized clustering coefficient gamma values, standard feature path length lambda values, small world attribute value sigma values, global network efficiency, local network efficiency, and brain signal complexity.
Further, the control module comprises a comparator and a light parameter regulator, wherein the comparator is used for comparing the concentration of the oxygenated hemoglobin and the deoxygenated hemoglobin and the brain network index with the standard value, and if the measured value exceeds the range of the standard value, the light stimulation parameter is regulated through the light parameter regulator.
Further, the near-infrared imaging module feeds back the concentration of oxygenated hemoglobin and deoxygenated hemoglobin of the cranial nerves and the change of brain network indexes in real time in the process of photostimulating the cranial nerves, and adjusts the photostimulation parameters in real time according to the concentration of the oxygenated hemoglobin and the deoxygenated hemoglobin and the change of the brain network indexes.
Further, the light stimulation parameter includes at least one of a light wavelength, a light intensity, a light time, a light location, a light range, and a distance of the light to the skin.
Further, the optical stimulation module comprises a light source, an optical irradiation probe and a probe position adjuster; the light source generates an optical signal with set light intensity and frequency, and transmits the optical signal to the light irradiation probe; the illumination area of the light irradiation probe can be adjusted according to the data signal acquired by the infrared imaging module and is used for implementing fixed-point illumination on the region corresponding to the specific disease of the brain; the probe position adjuster is connected with the light irradiation probe and is used for adjusting and locking the light irradiation position of the light irradiation probe.
Further, a light transmission module is arranged between the light source and the light irradiation probe and used for transmitting the light signal generated by the light source to the light irradiation probe.
Further, the probe position adjuster is a transmitter capable of three-dimensional movement, and the transmitter drives the light irradiation probe to move three-dimensionally according to the instruction of the control module.
Furthermore, the near-infrared imaging module, the control module and the light stimulation module are integrated on a flexible substrate, and the flexible substrate is in a cap-shaped structure.
Due to the adoption of the technical scheme, the invention has the following advantages: 1. the light signal is input to a specific part of the human brain, so that the Adenosine Triphosphate (ATP) in the human brain is increased, the activity of the human brain is enhanced, and the cognitive ability of the human brain is improved. 2. The human brain is monitored in real time through near-infrared brain imaging, and information such as the intensity, wavelength, illumination area and the like of the optical signal is adjusted according to the obtained brain network index, so that the optical stimulation signal for regulating the cranial nerves is completely determined according to the specific condition of the brain of a user, and the optical stimulation regulation is more targeted. 3. Judging whether the user may suffer from diseases such as depression, autism, Alzheimer's disease, Parkinson's disease or the like according to the comparison result of the comprehensive brain network indexes and the standard valuesEpilepsy, etc., and based on the diagnosis Can be used for treating the above diseases by performing targeted light stimulation on the head of the userThe disease has the effects of relieving and adjuvant treating. 4. When the device is used by a healthy user, the brain health condition of the user can be known at any time, and the cognitive ability of the user is improved. 5. The device is integrated on the cap-shaped flexible material, has simple structure and convenient carrying, and increases the demandThe comfort of the user to be monitored and treated for a long time.
Drawings
Fig. 1 is a schematic structural diagram of a brain light stimulation control device according to an embodiment of the present invention.
Detailed Description
The present invention is described in detail by way of specific embodiments in order to better understand the technical direction of the present invention for those skilled in the art. It should be understood, however, that the detailed description is provided for a better understanding of the invention only and that they should not be taken as limiting the invention. In describing the present invention, it is to be understood that the terminology used is for the purpose of description only and is not intended to be indicative or implied of relative importance.
The present embodiment provides a brain light stimulation modulation device, as shown in fig. 1, including: the near-infrared imaging module, the control module and the light stimulation module are connected in sequence; the near-infrared imaging module irradiates the brain to obtain the concentration of oxygenated hemoglobin and deoxygenated hemoglobin of the brain and brain network indexes, and transmits the obtained result to the control module; the control module analyzes the result obtained by the near-infrared imaging module and adjusts the parameters of the light stimulation module according to the result; the light stimulation module stimulates a specific region of the brain with parameters determined by the control module. The embodiment monitors the human brain in real time through near-infrared brain imaging, and adjusts information such as intensity, wavelength, illumination area and the like of optical signals according to the obtained brain network index, so that optical stimulation signals for brain nerve regulation are completely determined according to the specific condition of the brain of a user, and the optical stimulation regulation is more targeted. According to the comparison result of the comprehensive brain network indexes and the standard value, the fact that the user is possibly suffered from diseases such as depression, autism, Alzheimer's disease, Parkinson's disease, epilepsy and the like is judged, and targeted light stimulation is performed on the head of the user according to the diagnosis result, so that the effects of relieving and assisting in treatment of the diseases are achieved. And simultaneously, the brain cognitive ability of healthy users is improved.
The near-infrared imaging module in this embodiment includes: the device comprises a near-infrared light emitter, a near-infrared light receiver and an optical signal processor which are arranged in pairs. The near infrared light emitter is used for emitting near infrared light; the near-infrared light receiver is used for receiving a near-infrared transmitted light signal passing through brain tissue; the optical signal processor is used for converting the near-infrared transmission light signal into oxygenated hemoglobin concentration and deoxygenated hemoglobin concentration according to a modified Beer-Lambert law; and removing motion artifacts and physiological noise from the concentration signal, and performing band-pass filtering. Then, a brain network index is calculated from the oxyhemoglobin and deoxyhemoglobin concentrations. The brain network indexes include: the brain network indexes comprise brain function connectivity, brain network aggregation coefficients, network shortest paths, normalized clustering coefficient gamma values, standard characteristic path length lambda values, small world attribute value sigma values, global network efficiency, local network efficiency and brain signal complexity. The optical signal processor can be arranged together with the near-infrared light emitter and the near-infrared light receiver so as to facilitate the processing of the near-infrared transmission light signal; however, in order to make the near-infrared imaging module more portable, the optical signal processor may not be disposed together with the near-infrared light emitter and the near-infrared light receiver. For example, the optical signal processor may be provided in the control module. And the data of the near-infrared imaging module is transmitted to the control module through the communication module. Wherein, communication module can include data line, data interface etc. but preferred communication module is wireless communication module, like WIFI, GPRS, bluetooth etc..
The control module comprises a comparator and a light parameter regulator, wherein the comparator is used for comparing the concentration of oxygenated hemoglobin and deoxygenated hemoglobin and the brain network index with a standard value, and if the measured value exceeds the range of the standard value, the light stimulation parameter is regulated through the light parameter regulator. For example, if the global network efficiency of the brain is low, the light stimulation module can automatically adjust the illumination position, and the light parameter controller automatically controls the illumination area and the light intensity until the global network efficiency reaches a set threshold value. The standard value can be a standard value range of each brain network index stored in a database, or each brain network index of a healthy user, or a brain network index obtained by performing near-infrared brain imaging by the user in the past, or any other index which can be used as a reference standard. The standard value herein is usually a range of values, not a single value. The control module can synthesize the brain network indexes and the standard values to judge the brain health condition of the user or the suffered diseases. For example, many psychiatric diseases are associated with abnormalities in the topological properties of the brain network, and there are features of reduced small world properties in particular. Longer characteristic path length and higher clustering coefficient appear in the brain network of the Alzheimer disease patient; the brain function network cluster coefficient of the mental patient is reduced, the shortest path is lengthened, and the property of the small world is reduced; the brain function network cluster coefficient of the children hyperkinetic syndrome patient is increased, and is particularly obvious in occipital lobe, temporal lobe and frontal lobe. The control module can include a display device, and display device is used for showing user's brain health degree, and display device can be the display and also can be voice broadcast, or shows through display device's colour, and display device is not limited to visual display anyway, can adopt any kind to play the device of reminding the function as display device.
In the embodiment, the brain imaging module can detect the brain function before the light stimulates the cranial nerves, determine the parameters of the position, the intensity and the like of the light stimulation, and simultaneously, in the whole light stimulation process, the brain imaging module can also monitor the condition of the cranial nerves at any time, and is used for detecting whether the setting of the parameters of the position, the range, the light intensity and the like of the light stimulation is reasonable or not and whether the adjustment is needed or not, and feeding back the information detected in real time to the control module. The control module is also internally provided with a feedback device which is used for receiving the information fed back by the brain imaging module, analyzing and processing the information fed back according to a preset algorithm in a program, judging whether the initially determined light stimulation scheme is reasonable or not, and further optimizing parameters of the scheme if the scheme is reasonable, such as fine adjustment of parameters of illumination intensity, wavelength, area, position and the like, so as to achieve a better light stimulation effect. If the initial light stimulation scheme is unreasonable, the scheme is adjusted, so that the harm to a user due to improper operation is avoided, and the safety and the accuracy of light stimulation are improved.
The embodiment also comprises a light stimulation module which is controlled by the control moduleThe outgoing signal adjusts the illumination parameter, is used for adjusting the cranial nerves of the user and has certain auxiliary treatment effect on the cerebral diseases; it also has cognitive function improving effect for healthy users. The photostimulation module can relieve brain diseases and improve cognitive ability due to absorption of photons by Cytochrome C Oxidase (CCO) in human brain. Cytochrome c oxidase is located at the end of the cytochrome system in cellular respiration, and this enzyme transfers the electrons of the respiratory substrate directly to molecular oxygen via the cytochrome system. The light emitted from the light emitting module passes through a series of layers such as the scalp, periosteum, skull, meninges and dura mater, and finally reaches the surface of the human cerebral cortex, and is absorbed by the CCO. CCO plays a key role in brain metabolism, and the higher its activity, the higher the oxygen consumption and metabolic capacity of mitochondria. ATP, which is a high-energy compound in organisms, is mainly produced by mitochondria, is usually present inside cells, and serves as an energy currency molecule to support various metabolic activities of cells. Mitochondria are the most prominent source of intracellular ATP, determining ATP levels. Therefore, the increase of oxygen consumption and metabolism of mitochondria can lead to increase of ATP in cells, thereby promoting the growth and development of human brain cells, and the increase of ATP at a certain level can stimulate free Ca in cells2+Increase in molecular content of Nitric Oxide (NO), Reactive Oxygen Species (ROS), etc. Wherein NO binds to CCO to inhibit CCO activity and reduce ATP production. The light signal absorbed by the CCO can increase ATP yield by separating NO, thereby preventing NO from binding to CCO. Therefore, the light stimulation can relax blood vessels of the brain, increase blood circulation, promote cerebral neuroprotection and enhance cerebral cognitive function.
The optical stimulation module in the embodiment comprises a light source, an optical irradiation probe and a probe position adjuster which are sequentially connected; the light source is connected with the control module and generates the light intensity, the wavelength and the illumination time of a specific light signal according to the instruction of the control module; the light source generates an optical signal with set light intensity and frequency, and transmits the optical signal to the light irradiation probe; the probe position adjuster is connected with the light irradiation probe, the probe position adjuster adjusts the position of the light irradiation probe according to the instruction of the control module, and the control module can also adjust and control the illumination area of the light irradiation probe.
In order to facilitate the fixation of the light irradiation probe, the light stimulation module in this embodiment further includes a fixer for fixing and carrying the light irradiation probe and the probe position adjuster. The holder is preferably a cap-like holder that can be worn on the head, which is in turn preferably a flexible holder to increase the comfort of the user. The fixer can fix only one light irradiation probe and one probe position adjuster, and can also bear a plurality of light irradiation probes and probe position adjusters. The light irradiation probes can be movable or fixed, the number of the light irradiation probes can correspond to the number of the probe position regulators, only one probe regulation module can be arranged, and the probe regulation module can move the light irradiation probes to corresponding positions. The probe position regulator is preferably a transmitter capable of three-dimensional movement, and the transmitter drives the light irradiation probe to move three-dimensionally according to the instruction of the control module. Namely, the transmitter can not only adjust the illumination position and the illumination area, but also adjust the distance from the light irradiation probe to the skin of the irradiation part, and automatically adjust the distance from the light irradiation probe to the skin according to the characteristics such as skin temperature and the like, thereby avoiding the burn of a user and ensuring that the light irradiation device is safer and more reliable
In this embodiment, the light source and the light irradiation probe may be directly connected to each other, or may be connected to each other through a light transmission module disposed therebetween, where the light transmission module may be an optical fiber or the like, and the light transmission module is configured to transmit a light signal generated by the light source to the light irradiation probe. If the light generated by the light source is in the near-infrared wavelength range, the light source can also be used as a near-infrared light emitter of the brain imaging module, and only a corresponding light transmission module needs to be arranged. The arrangement mode enables the device structure to be simpler and more portable.
Both the light source and the near infrared light emitter may be laser emitters, for example diode laser emitters, preferably laser emitters with a larger wavelength range.
The above embodiments are only for illustrating the present invention, and the structure, size, arrangement position and shape of each component can be changed, such as the appearance size, fixing manner, lead wire manner and geometric configuration after assembly of each component.
Claims (10)
1. A brain light stimulation modulation device, comprising: the near-infrared imaging module, the control module and the light stimulation module are connected in sequence;
the near-infrared imaging module illuminates the brain to obtain the concentration of oxygenated hemoglobin and deoxygenated hemoglobin of the brain and brain network indexes, and transmits the obtained result to the control module;
the control module analyzes the result obtained by the near-infrared imaging module and adjusts the parameters of the light stimulation module according to the result;
the light stimulation module stimulates a specific region of the brain with the parameters determined by the control module.
2. The brain light stimulation modulation device according to claim 1, wherein the near-infrared imaging module comprises a near-infrared light emitter, a near-infrared light receiver and an optical signal processor, which are arranged in pairs, the near-infrared light emitter being configured to emit near-infrared light; the near-infrared light receiver is used for receiving a near-infrared transmitted light signal passing through brain tissue; the optical signal processor is used for converting the near-infrared transmission optical signal into the concentrations of oxyhemoglobin and deoxyhemoglobin and calculating the brain network index according to the concentrations of oxyhemoglobin and deoxyhemoglobin.
3. The brain light stimulation modulation device according to claim 2, wherein the brain network indices include brain functional connectivity, brain network aggregation coefficients, network shortest paths, normalized clustering coefficient γ values, standard feature path length λ values, small world attribute value σ values, global network efficiency, local network efficiency, and brain signal complexity.
4. The brain light stimulation regulation device according to any one of claims 1 to 3, wherein the control module comprises a comparator and a light parameter regulator, the comparator is used for comparing the oxyhemoglobin, the deoxyhemoglobin concentration and the brain network index with standard values, and if the measured value is out of the range of the standard values, the light parameter regulator is used for regulating the light stimulation parameters.
5. The brain light stimulation regulation device according to claim 4, wherein the near-infrared imaging module feeds back oxyhemoglobin, deoxyhemoglobin concentration and brain network index change of the brain nerve in real time during the light stimulation of the brain nerve, and adjusts the light stimulation parameter in real time according to the oxyhemoglobin, deoxyhemoglobin concentration and brain network index change.
6. The brain light stimulation modulation device according to claim 5, wherein the light stimulation parameters include at least one of light wavelength, light intensity, light time, light location, light range, and light-to-skin distance.
7. The brain light stimulation regulation device according to any one of claims 1 to 3, wherein the light stimulation module comprises a light source, a light irradiation probe and a probe position adjuster; the light source generates an optical signal with set light intensity and frequency, and transmits the optical signal to the light irradiation probe; the illumination area of the light irradiation probe can be adjusted according to the data signal acquired by the infrared imaging module and is used for implementing fixed-point illumination on the area corresponding to the specific disease of the brain; the probe position adjuster is connected with the light irradiation probe and used for adjusting and locking the light irradiation position of the light irradiation probe.
8. The brain light stimulation regulation device of claim 7, wherein a light transmission module is further disposed between the light source and the light irradiation probe, and the light transmission module is configured to transmit the light signal generated by the light source to the light irradiation probe.
9. The brain light stimulation regulation device according to claim 7 or 8, wherein the probe position adjuster is a transmitter capable of three-dimensional movement, and the transmitter drives the light irradiation probe to move three-dimensionally according to the instruction of the control module.
10. The brain light stimulation modulation device according to any one of claims 1-3, wherein the near-infrared imaging module, the control module and the light stimulation module are integrated on a flexible substrate, and the flexible substrate is in a cap-shaped structure.
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| CN112057046A (en) * | 2020-09-10 | 2020-12-11 | 南京诺源医疗器械有限公司 | Tumor fluorescence imaging spectrum diagnostic apparatus |
| CN112657037A (en) * | 2021-01-11 | 2021-04-16 | 华中科技大学 | Intelligent mental disorder treatment equipment based on variable light |
| CN115779277A (en) * | 2022-11-03 | 2023-03-14 | 东北大学 | Infrared light nerve regulation and control method and storage medium for brain severe diseases |
| WO2024022381A1 (en) * | 2022-07-26 | 2024-02-01 | Danyang Huichuang Medical Equipment Co., Ltd. | Phototherapy apparatus for treating alzheimer's disease |
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