CN216125063U - Transcranial magnetic stimulation intervention device - Google Patents
Transcranial magnetic stimulation intervention device Download PDFInfo
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- CN216125063U CN216125063U CN202122052706.0U CN202122052706U CN216125063U CN 216125063 U CN216125063 U CN 216125063U CN 202122052706 U CN202122052706 U CN 202122052706U CN 216125063 U CN216125063 U CN 216125063U
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Abstract
The utility model relates to a transcranial magnetic stimulation intervention device which comprises an acquisition module, a control module and a transcranial magnetic stimulation module. The acquisition module and the transcranial magnetic stimulation module are respectively and electrically connected with the control module; the acquisition module acquires near-infrared variation amplitude of a target brain region before and after transcranial magnetic stimulation; the control module judges whether the near-infrared change amplitude of the target brain area exceeds a set threshold value or not, and when the near-infrared change amplitude of the target brain area exceeds the set threshold value, the transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain area are matched; and the transcranial magnetic stimulation module stimulates the target brain area according to the transcranial magnetic stimulation parameters. The transcranial magnetic stimulation intervention device can intuitively show the change of the intervened target brain region by monitoring the near-infrared change amplitude of the target brain region through transcranial magnetic stimulation of the target brain region including a motor brain region and a non-motor brain region, and can match a corresponding transcranial magnetic stimulation scheme according to the near-infrared change amplitude before and after stimulation so as to achieve the effect of effective treatment.
Description
Technical Field
The utility model relates to the technical field, in particular to a transcranial magnetic stimulation intervention device.
Background
Transcranial Magnetic Stimulation (TMS) technology is a Magnetic Stimulation technology that uses a pulsed Magnetic field to act on the central nervous system (mainly the brain) to change the membrane potential of cortical nerve cells, so that induced current is generated to influence intracerebral metabolism and neuroelectrical activity, thereby causing a series of physiological and biochemical reactions.
Transcranial magnetic stimulation induces electrical currents in the brain through the electromagnetic induction principle of faraday. In short, the basic principle of transcranial magnetic stimulation is divided into two parts. In the first part, the control system commands the host machine to deliver a current through the multiply wound coil, the rapid change in current producing a toroidal magnetic field perpendicular to the plane of the coil.
In the second part, after the circular magnetic field passes through the skull without resistance, the intracranial brain substance is used as a conductive medium, and circular induction micro-current which is parallel to the coil and has opposite current direction is generated again, and the current has the functions of regulating nerve activity and local microenvironment.
Transcranial magnetic stimulation technology modulates local cortical excitability through an annular microcurrent generated intracranially. At present, the treatment of motor dysfunction through transcranial magnetic stimulation is mainly focused on primary motor cortex, and the main observation index is MEP (motor evoked potential). When the therapist treats motor dysfunction using transcranial magnetic stimulation, whether to stimulate to the target region may be judged by the movement of the target muscle.
However, the intervention of transcranial magnetic stimulation in the non-motor brain region has no clear index to intuitively show whether the transcranial magnetic stimulation intervenes in the target cortex. In addition, the transcranial magnetic stimulation has different activation conditions on the cortex when the transcranial magnetic stimulation is at different stimulation intensities and stimulation frequencies, and the activation degrees of the same intensity and frequency among different individuals are different, so that no effective device is available for solving the individuation problem of transcranial magnetic stimulation intervention at present.
SUMMERY OF THE UTILITY MODEL
Therefore, a transcranial magnetic stimulation intervention device capable of visually representing whether transcranial magnetic stimulation intervenes in a target cortex or not is provided for solving the problem that when transcranial magnetic stimulation intervenes in a non-motor brain region, no clear index visually represents whether transcranial magnetic stimulation intervenes in the target cortex or not.
A transcranial magnetic stimulation intervention device comprises an acquisition module, a control module and a transcranial magnetic stimulation module, wherein the acquisition module and the transcranial magnetic stimulation module are respectively and electrically connected with the control module; the acquisition module acquires near-infrared variation amplitude of a target brain region before and after transcranial magnetic stimulation; the control module judges whether the near-infrared variation amplitude of the target brain area exceeds a set threshold value or not, and when the near-infrared variation amplitude of the target brain area exceeds the set threshold value, the transcranial magnetic stimulation parameters corresponding to the near-infrared variation amplitude of the target brain area are matched;
and the transcranial magnetic stimulation module stimulates the target brain area according to the transcranial magnetic stimulation parameters.
Further, the acquisition module acquires near-infrared variation amplitude of the whole brain region before and after transcranial magnetic stimulation; and the control module compares whether the near infrared change amplitude of the target brain area exceeds the set threshold value by taking the near infrared change amplitude of the whole brain area as a reference.
Further, the control module monitors the near-infrared real-time variation amplitude of the target brain area, and adjusts transcranial magnetic stimulation parameters according to the real-time variation amplitude.
Furthermore, transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain region are prestored in the control module.
Furthermore, the device also comprises a near-infrared signal generating module used for sending a near-infrared signal, and the near-infrared signal generating module is electrically connected with the control module.
Furthermore, the acquisition module and the near-infrared signal generation module are integrated into a functional near-infrared device, and the functional near-infrared device is electrically connected with the control module.
Furthermore, the device also comprises an indicator light, and the indicator light is connected with the control module.
Further, when the near infrared change amplitude of the target brain region does not exceed a set threshold value, the control module sends out an alarm signal to control the transcranial magnetic stimulation module to enhance transcranial magnetic stimulation.
The transcranial magnetic stimulation intervention device can intuitively show the change of the intervened target brain region by monitoring the near-infrared change amplitude of the target brain region through transcranial magnetic stimulation of the target brain region including a motor brain region and a non-motor brain region, and can match a corresponding transcranial magnetic stimulation scheme according to the near-infrared change amplitude before and after stimulation so as to achieve the effect of effective treatment.
Drawings
FIG. 1 is a schematic view of a transcranial magnetic stimulation intervention device according to one embodiment;
FIG. 2 is a functional near-infrared monitoring schematic diagram;
FIG. 3 is a flow chart of a transcranial magnetic stimulation intervention method according to an embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1, in one embodiment, a transcranial magnetic stimulation intervention device includes an acquisition module 410, a control module 420, a transcranial magnetic stimulation module 430, and a near-infrared signal generation module 440, where the acquisition module 410, the transcranial magnetic stimulation module 430, and the near-infrared signal generation module 400 are respectively electrically connected to the control module 420.
The obtaining module 410 is used for obtaining the near-infrared variation amplitude of the target brain region and the near-infrared variation amplitude of the whole brain region before and after transcranial magnetic stimulation. The near-infrared generating module 440 is used for emitting a near-infrared signal. Specifically, the near-infrared signal generating module 440 and the acquiring module 410 are integrated into a functional near-infrared device, and the functional near-infrared device is worn on the head of the patient, which can monitor the near-infrared signal change conditions of the whole brain area and the target brain area. The functional near-infrared device has good capability of resisting electromagnetic interference and movement interference, has higher reliability in both sensitivity and specificity of reflecting nervous excitability change, and is an ideal tool for solving the problem of individuation of transcranial magnetic stimulation non-motor brain area stimulation.
The control module 420 is configured to determine whether the near-infrared variation amplitude of the target brain region exceeds a set threshold, and when the near-infrared variation amplitude of the target brain region exceeds the set threshold, match the transcranial magnetic stimulation parameter corresponding to the near-infrared variation amplitude of the target brain region. The device is also used for monitoring the near-infrared real-time change amplitude of the target brain area and adjusting the transcranial magnetic stimulation parameters according to the real-time change amplitude. The transcranial magnetic stimulation intervention device comprises an indicator light, and the indicator light is connected with the control module. And when the set threshold value is exceeded, the indicator light is green, and when the set threshold value is not exceeded, the indicator light is red. The control module 420 has a database in which transcranial magnetic stimulation parameters corresponding to the near-infrared variation range of the target brain region are pre-stored, and drives the transcranial magnetic stimulation device to deliver targeted therapy to the patient according to the pre-stored parameters. The database is a local database or a cloud database, and corresponding data updating can be carried out so as to update and modify the transcranial magnetic stimulation scheme in time. For example, the stimulus is considered to be effective when the target brain region near-infrared signal variation amplitude exceeds 10% of the whole brain signal variation amplitude. If the near infrared change amplitude of the target brain region does not exceed the set threshold, an alarm signal is sent out, transcranial magnetic stimulation is enhanced, and the near infrared change amplitude of the target brain region is continuously monitored. For example, when the change amplitude of the near-infrared signal of the target brain region does not exceed 10% of the change amplitude of the whole brain signal, the stimulation is determined to be invalid, and the system can indicate that the stimulation is invalid by lighting a red light to remind an operator to readjust.
Transcranial magnetic stimulation module 430 is configured to stimulate the target brain region according to transcranial magnetic stimulation parameters. The transcranial magnetic stimulation module 430 is a transcranial magnetic therapeutic apparatus.
The transcranial magnetic stimulation intervention device can intuitively show the change of the intervened target brain region by monitoring the near-infrared change amplitude of the target brain region through transcranial magnetic stimulation of the target brain region including a motor brain region and a non-motor brain region, and can match a corresponding transcranial magnetic stimulation scheme according to the near-infrared change amplitude before and after stimulation so as to achieve the effect of effective treatment.
In addition, a transcranial magnetic stimulation intervention method is also provided.
As shown in FIG. 3, in one embodiment, a transcranial magnetic stimulation intervention method comprises the following steps:
and step S110, acquiring the near-infrared change amplitude of the target brain region before and after transcranial magnetic stimulation. Functional near-infrared spectroscopy (fNIRS) assesses neural activity through optical signal changes, with two central principles. Referring to fig. 2, the first core principle is the scattering and absorption of light. After the near infrared passes through the skull by the transmitting probe, part of light is absorbed due to the blockage of brain contents, the rest light is scattered, and finally, the light forms an arc-shaped light path in the brain and returns to the surface of the scalp to be received by the receiving probe. Because the absorption degree of light is different among HBO (oxyhemoglobin), HBR (deoxyhemoglobin) and water, the variation of the hemoglobin amount of the region passing through the 'optical path' can be obtained by analyzing the variation of the intensity of the scattered light. The second core principle is neuro-vascular coupling. Neuroscience studies have demonstrated that changes in neural activity are positively correlated with changes in their peripheral capillaries. When the nerve is active, its peripheral capillaries dilate and oxygenated hemoglobin increases, otherwise it decreases. fNIRS can monitor cortical hemodynamic changes throughout the head, reflecting changes in cortical neural activity.
And step S120, judging whether the near infrared change amplitude of the target brain area exceeds a set threshold value. If yes, the process proceeds to step S130. Because the activation degrees of transcranial magnetic stimulation in different individuals are different, in a preferred embodiment, the near-infrared change amplitude of the whole brain area before and after the transcranial magnetic stimulation is obtained, and the near-infrared change amplitude of the whole brain area is taken as a reference to compare whether the near-infrared change amplitude of the target brain area exceeds a set threshold value. For example, the stimulus is considered to be effective when the target brain region near-infrared signal variation amplitude exceeds 10% of the whole brain signal variation amplitude. If not, namely the near infrared change amplitude of the target brain region does not exceed the set threshold value, an alarm signal is sent out, transcranial magnetic stimulation is enhanced, and the near infrared change amplitude of the target brain region is continuously monitored. For example, when the change amplitude of the near-infrared signal of the target brain region does not exceed 10% of the change amplitude of the whole brain signal, the stimulation is determined to be invalid, and the system can indicate that the stimulation is invalid by lighting a red light to remind an operator to readjust.
And S130, matching transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain region. The transcranial magnetic stimulation parameters are usually intensity and frequency, and different stimulation intensities and stimulation frequencies of transcranial magnetic stimulation have different activation conditions on the cortex. Based on the analysis of the near-infrared signals, an internal database is established, and transcranial magnetic stimulation parameters corresponding to the near-infrared change amplitude of the target brain region are prestored. The patient is given targeted therapy by the tactical transcranial magnetic stimulation device according to pre-stored parameters. Meanwhile, the stimulation mode is adjusted according to the near-infrared signal change of the cerebral cortex in the treatment process and after the treatment. Monitoring the near-infrared real-time change amplitude of the target brain area, and adjusting the transcranial magnetic stimulation parameters according to the real-time change amplitude.
And step S140, stimulating the target brain area according to the transcranial magnetic stimulation parameters. And (3) comparing the change amplitude of the near-infrared signal of the target brain region with data in a database, screening out a corresponding transcranial magnetic stimulation scheme, and performing treatment by matching and selecting a stimulation mode with the highest fitting degree, so as to realize the self-adaptive adjustment of the stimulation scheme.
The utility model realizes the real-time monitoring in the transcranial magnetic stimulation treatment, and can adjust the stimulation scheme in real time according to the monitored information; the functional near-infrared signals are continuously acquired during treatment, and the stimulation scheme is continuously adjusted through real-time data matching and data analysis, so that the purpose of self-adaptive feedback individualized treatment is achieved.
In addition, through transcranial magnetic stimulation, the functional near-infrared device acquires the change of a near-infrared signal, so that the excitability of cortical neural activity during stimulation is judged, and the stimulation intensity is adjusted by comparing with data prestored in a database, so that the treatment intensity of each patient reaches the individual optimum intensity, and the rehabilitation curative effect is improved.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. A transcranial magnetic stimulation intervention device is characterized by comprising an acquisition module, a control module and a transcranial magnetic stimulation module, wherein the acquisition module and the transcranial magnetic stimulation module are respectively and electrically connected with the control module; the acquisition module acquires near-infrared variation amplitude of a target brain region before and after transcranial magnetic stimulation; the control module judges whether the near-infrared variation amplitude of the target brain area exceeds a set threshold value or not, and when the near-infrared variation amplitude of the target brain area exceeds the set threshold value, the transcranial magnetic stimulation parameters corresponding to the near-infrared variation amplitude of the target brain area are matched; and the transcranial magnetic stimulation module stimulates the target brain area according to the transcranial magnetic stimulation parameters.
2. The transcranial magnetic stimulation intervention method according to claim 1, wherein the obtaining module obtains near-infrared variation amplitudes of the whole brain region before and after transcranial magnetic stimulation; and the control module compares whether the near infrared change amplitude of the target brain area exceeds the set threshold value by taking the near infrared change amplitude of the whole brain area as a reference.
3. The transcranial magnetic stimulation intervention method according to claim 1, wherein the control module monitors real-time near-infrared amplitude of change of the target brain region and adjusts transcranial magnetic stimulation parameters according to the real-time amplitude of change.
4. The transcranial magnetic stimulation intervention method according to claim 1, wherein transcranial magnetic stimulation parameters corresponding to the target brain region near-infrared variation amplitude are pre-stored in the control module.
5. The transcranial magnetic stimulation intervention method according to claim 1, further comprising a near-infrared signal generation module for emitting a near-infrared signal, wherein the near-infrared signal generation module is electrically connected with the control module.
6. The transcranial magnetic stimulation intervention method according to claim 5, wherein the acquisition module and the near-infrared signal generation module are integrated into a functional near-infrared device, and the functional near-infrared device is electrically connected with the control module.
7. The transcranial magnetic stimulation intervention method according to claim 1, further comprising an indicator light, wherein the indicator light is connected with the control module.
8. The transcranial magnetic stimulation intervention method according to claim 1, wherein the control module issues an alarm signal to control the transcranial magnetic stimulation module to enhance transcranial magnetic stimulation when the amplitude of near-infrared change of the target brain region does not exceed a set threshold.
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