CN109846478A - A kind of assessment excitatoty method of cerebral cortex after cranium galvanic current stimulation - Google Patents
A kind of assessment excitatoty method of cerebral cortex after cranium galvanic current stimulation Download PDFInfo
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Abstract
A kind of assessment excitatoty method of cerebral cortex after cranium galvanic current stimulation, including, measured is carried out to stimulate the EEG data of front and back brain activity through cranium galvanic current stimulation using the acquisition of electroencephalogram acquisition electrode through cranium galvanic current stimulation；EEG data before and after collected stimulation is respectively processed, obtains and electrically activates index for assessing the excitatoty full brain brain of cerebral cortex after the stimulation of cranium galvanic current stimulation.The present invention passes through the excitatoty change of cerebral cortex after cranium galvanic current stimulation of brain electro-detection, and obtain to assess the quantitative parameter through cranium galvanic current stimulation to cerebral cortex excitability mediating effect+6 by extracting, calculating brain electrical feature, the movable regulating effect of Cortical Neurons is provided for tDCS and objectively evaluates index.The present invention not only facilitates its adjustment mechanism of profound understanding, can also provide objective basis with formulation to the selection of the parameters such as stimulus modality, stimulation metering.
Description
Technical field
The present invention relates to a kind of excitatoty appraisal procedures of cerebral cortex.It is pierced more particularly to a kind of assessment through cranium direct current
The excitatoty method of cerebral cortex after swashing.
Background technique
It is a kind of new through cranium galvanic current stimulation (transcranial Direct Current Stimulation, tDCS)
It is emerging, Noninvasive, utilize weak current (1~2mA) adjust the movable technology of Cortical Neurons.It is according to DC electrode
Property, neural discharge frequency come increase (promotion) or reduce (inhibition) nerve synapse transduction activity, to reach adjusting brain activity
Purpose.Research shows that tDCS intervention can enhance motor learning or memory, it may also be used for cognition or kinesitherapy nerve rehabilitation.But mesh
The preceding technological means for adjusting cerebral cortex effect for tDCS is extremely limited, monitors to quantification tDCS to Cortical Neurons
Movable regulating effect not only facilitates its adjustment mechanism of profound understanding, can also be to the choosing of the parameters such as stimulus modality, stimulation metering
It selects and offer objective basis is provided.
The activity of neuron can be evaluated and be reflected using EEG signals.EEG signals
(Electroencephalogram, EEG) signal is the brain cell group spontaneity recorded by scalp electrode, rhythmicity electricity
Activity is the concentrated expression of cranial nerve cell group's bioelectrical activity.This patent proposes to utilize brain skin after EEG detection tDCS stimulation
Layer neuron activity.
Summary of the invention
It can be tDCS to the movable tune of Cortical Neurons the technical problem to be solved by the invention is to provide one kind
Section effect provides the assessment for objectively evaluating index excitatoty method of cerebral cortex after cranium galvanic current stimulation.
The technical scheme adopted by the invention is that: a kind of assessment excitatoty side of cerebral cortex after cranium galvanic current stimulation
Method, including, measured is carried out through cranium galvanic current stimulation, before being stimulated using the acquisition of electroencephalogram acquisition electrode through cranium galvanic current stimulation
The EEG data of brain activity afterwards；EEG data before and after collected stimulation is respectively processed, is obtained for commenting
Estimate the excitatoty full brain brain electrical activation index of the cerebral cortex after the stimulation of cranium galvanic current stimulation.
The acquisition stimulates the EEG data of front and back brain activity through cranium galvanic current stimulation, specifically includes: allowing tested
Person is quiet, opens eyes, is sitting on chair, and acquisition measured stimulates preceding 5 minutes EEG datas, then carries out measured through cranium
After galvanic current stimulation stimulation, 5 minutes EEG datas after acquisition measured's stimulation, when acquisition also require that measured it is quiet,
It opens eyes, be sitting on chair.
The acquisition electrode position of sound production of stimulating electrode and acquisition EEG data through cranium galvanic current stimulation is all in accordance with the world
It places the system position standard lead 10-20, wherein the corresponding left side cerebral cortex prefrontal lobe of lead F3 in lead 10-20 system
Lateral area is carried on the back, places the anode electrode through cranium galvanic current stimulation, region is placed through cranium galvanic current stimulation on the forehead socket of the eye of right side
Cathode electrode；Lead F3, FP1, F7, FT7, FC3, FCZ, FZ, T3, C3, CZ, FC4, F4, FP2, F8, FT8, T4 position of sound production brain
Electrograph acquisition electrode.
Described is respectively processed the EEG data before and after collected stimulation, sets each lead first and obtains
Stimulation before EEG data be Pr, after stimulation EEG data be Po, respectively to each lead stimulation front and back electroencephalogram number
According to being handled, specifically include:
(1) 1-20Hz bandpass filtering is carried out to EEG data Po after EEG data Pr before stimulating and stimulation respectively, it is right
It should obtain filtered data: Pr_f and Po_f；
(2) data Pr_f being divided into every 20 seconds one section of data segments, each data Pr_f is divided into 15 segment datas, according to
Fast Fourier Transform (FFT) calculates the power of the β wave of the δ wave of the 2-4Hz in every segment data, the θ wave of 4-8Hz and 12-18Hz, by 15
The resulting δ popin mean value of segment data, θ popin mean value and β popin mean value correspond to the absolute power of wave band respectively as data Pr_f
Value: Pr_power_ δ, Pr_power_ θ and Pr_power_ β；Data Po_f is divided into every 20 seconds one section of data segments, it is each
A data Po_f is divided into 15 segment datas, calculates the δ wave of the 2-4Hz in every segment data, the θ of 4-8Hz according to Fast Fourier Transform (FFT)
The power of the β wave of wave and 12-18Hz, using the resulting δ popin mean value of 15 segment datas, θ popin mean value and β popin mean value as
Data Po_f corresponds to the absolute power level of wave band: Po_power_ δ, Po_power_ θ and Po_power_ β；
(3) according to the following formula, difference power Δ δ, Δ θ, the Δ β of each lead in stimulation front and back are calculated separately:
(4) calculate separately according to the following formula each lead brain electrical activation exponent gamma _ F3, γ _ FP1, γ _ F7, γ _ FT7,
γ_FC3、γ_FCZ、γ_FZ、γ_T3、γ_C3、γ_CZ、γ_FC4、γ_F4、γ_FP2、γ_F8、γ_FT8、γ_T4
+ 0.5 Δ β (4) of+0.9 Δ θ of γ _ Y=0.6 Δ δ
Wherein, Y is corresponding lead F3, FP1, F7, FT7, FC3, FCZ, FZ, T3, C3, CZ, FC4, F4, FP2, F8, FT8
And T4；
(5) weight is respectively set to each of 16 leads lead, weight is divided into 0.5,0.3,0.15,0.05 4
Grade, wherein the lead under 0.5 weight are as follows: F3；Lead under 0.3 weight are as follows: FP1, F7, FT7, FC3, FCZ, FZ；0.15 power
Lead under again are as follows: T3, C3, CZ, FC4, F4；Lead under 0.05 weight are as follows: FP2, F8, FT8, T4 are used according to the following formula
In assessment, the excitatoty full brain brain of cerebral cortex electrically activates exponent gamma after cranium galvanic current stimulation:
A kind of assessment of the invention excitatoty method of cerebral cortex after cranium galvanic current stimulation, by brain electro-detection through cranium
The excitatoty change of cerebral cortex after galvanic current stimulation, and obtain to assess through cranium direct current by extracting, calculating brain electrical feature
Electro photoluminescence is tDCS to the movable regulating effect of Cortical Neurons to the quantitative parameter of cerebral cortex excitability mediating effect+6
Offer objectively evaluates index.The present invention not only facilitates its adjustment mechanism of profound understanding, can also be to stimulus modality, stimulation metering etc.
The selection and formulation of parameter provide objective basis.
Detailed description of the invention
Fig. 1 is that 32 lead 10-20 electrode position of international standard places schematic diagram.
Specific embodiment
Below with reference to embodiment and attached drawing to a kind of assessment of the invention the cerebral cortex excitability after cranium galvanic current stimulation
Method be described in detail.
A kind of assessment of the invention excitatoty method of cerebral cortex after cranium galvanic current stimulation, including, to measured into
Pass through cranium galvanic current stimulation (tDCS), before being stimulated using the acquisition of electroencephalogram (EEG) acquisition electrode through cranium galvanic current stimulation (tDCS)
The EEG data of brain activity afterwards；EEG data before and after collected stimulation is respectively processed, is obtained for commenting
Estimate the excitatoty full brain brain electrical activation index of the cerebral cortex after the stimulation of cranium galvanic current stimulation.
Heretofore described acquisition stimulates the EEG data of front and back brain activity, tool through cranium galvanic current stimulation (tDCS)
Body includes: to allow measured is quiet, opens eyes, is sitting on chair, and acquisition measured stimulates preceding 5 minutes EEG datas, then right
Measured carries out after cranium galvanic current stimulation stimulates, 5 minutes EEG datas after acquisition measured's stimulation, and when acquisition is equally wanted
Measured's peace and quiet are asked, opens eyes, be sitting on chair.
Wherein, the acquisition electrode position of sound production of stimulating electrode through cranium galvanic current stimulation and acquisition EEG data all in accordance with
It places the international standard system position lead 10-20, wherein before the corresponding left side cerebral cortex of lead F3 in lead 10-20 system
Frontal lobe carries on the back lateral area, places the anode electrode through cranium galvanic current stimulation；Region is placed and is pierced through cranium direct current on the forehead socket of the eye of right side
Sharp cathode electrode, lead F3, FP1, F7, FT7, FC3, FCZ, FZ, T3, C3 in lead 10-20 system as shown in Figure 1,
CZ, FC4, F4, FP2, F8, FT8, T4 position of sound production electroencephalogram acquisition electrode.
Heretofore described is respectively processed the EEG data before and after collected stimulation, and setting first is each
EEG data is Pr before the stimulation that lead obtains, and EEG data is Po after stimulation, respectively to each lead stimulation front and back
EEG data is handled, and is specifically included:
(1) 1-20Hz bandpass filtering is carried out to EEG data Po after EEG data Pr before stimulating and stimulation respectively, it is right
It should obtain filtered data: Pr_f and Po_f；
(2) data Pr_f being divided into every 20 seconds one section of data segments, each data Pr_f is divided into 15 segment datas, according to
Fast Fourier Transform (FFT) calculates the power of the β wave of the δ wave of the 2-4Hz in every segment data, the θ wave of 4-8Hz and 12-18Hz, by 15
The resulting δ popin mean value of segment data, θ popin mean value and β popin mean value correspond to the absolute power of wave band respectively as data Pr_f
Value: Pr_power_ δ, Pr_power_ θ and Pr_power_ β；Data Po_f is divided into every 20 seconds one section of data segments, it is each
A data Po_f is divided into 15 segment datas, calculates the δ wave of the 2-4Hz in every segment data, the θ of 4-8Hz according to Fast Fourier Transform (FFT)
The power of the β wave of wave and 12-18Hz, using the resulting δ popin mean value of 15 segment datas, θ popin mean value and β popin mean value as
Data Po_f corresponds to the absolute power level of wave band: Po_power_ δ, Po_power_ θ and Po_power_ β；
(3) according to the following formula, difference power Δ δ, Δ θ, the Δ β of each lead in stimulation front and back are calculated separately:
(4) calculate separately according to the following formula each lead brain electrical activation exponent gamma _ F3, γ _ FP1, γ _ F7, γ _ T7, γ _
FC3、γ_FCZ、γ_FZ、γ_T3、γ_C3、γ_CZ、γ_FC4、γ_F4、γ_FP2、γ_F8、γ_FT8、γ_T4
+ 0.5 Δ β (4) of+0.9 Δ θ of γ _ Y=0.6 Δ δ
Wherein, Y is corresponding lead F3, FP1, F7, FT7, FC3, FCZ, FZ, T3, C3, CZ, FC4, F4, FP2, F8, FT8
And T4；
(5) weight is respectively set to each of 16 leads lead, weight is divided into 0.5,0.3,0.15,0.05 4
Grade, wherein the lead under 0.5 weight are as follows: F3；Lead under 0.3 weight are as follows: FP1, F7, FT7, FC3, FCZ, FZ；0.15 power
Lead under again are as follows: T3, C3, CZ, FC4, F4；Lead under 0.05 weight are as follows: FP2, F8, FT8, T4 are used according to the following formula
In assessment, the excitatoty full brain brain of cerebral cortex electrically activates exponent gamma after cranium galvanic current stimulation:
Claims (4)
1. it is a kind of assessment after cranium galvanic current stimulation the excitatoty method of cerebral cortex, which is characterized in that including, to measured into
It passes through cranium galvanic current stimulation, stimulates the electroencephalogram of front and back brain activity through cranium galvanic current stimulation using the acquisition of electroencephalogram acquisition electrode
Data；EEG data before and after collected stimulation is respectively processed, obtains and is pierced for assessing through cranium galvanic current stimulation
The excitatoty full brain brain of cerebral cortex electrically activates index after swashing.
2. a kind of the assessment excitatoty method of cerebral cortex, feature after cranium galvanic current stimulation according to claim 1
It is, the acquisition stimulates the EEG data of front and back brain activity through cranium galvanic current stimulation, specifically includes: measured being allowed to pacify
It is quiet, open eyes, be sitting on chair, acquisition measured stimulates preceding 5 minutes EEG datas, then carries out measured through cranium direct current
After electro photoluminescence stimulation, 5 minutes EEG datas after acquisition measured's stimulation, when acquisition also requires that measured is quiet, opens eyes,
It is sitting on chair.
3. a kind of the assessment excitatoty method of cerebral cortex, feature after cranium galvanic current stimulation according to claim 2
It is, the acquisition electrode position of sound production of the stimulating electrode through cranium galvanic current stimulation and acquisition EEG data is all in accordance with international standard
It places the system position lead 10-20, wherein outside the corresponding left side cerebral cortex forehead blade back of lead F3 in lead 10-20 system
Side region places the anode electrode through cranium galvanic current stimulation, and the cathode through cranium galvanic current stimulation is placed in region on the forehead socket of the eye of right side
Electrode；Lead F3, FP1, F7, FT7, FC3, FCZ, FZ, T3, C3, CZ, FC4, F4, FP2, F8, FT8, T4 position of sound production electroencephalogram
Acquisition electrode.
4. a kind of the assessment excitatoty method of cerebral cortex, feature after cranium galvanic current stimulation according to claim 1
It is, the EEG data to before and after collected stimulation is respectively processed, and sets what each lead obtained first
EEG data is Pr before stimulating, and EEG data is Po after stimulation, respectively to the EEG data of each lead stimulation front and back
It is handled, is specifically included:
(1) 1-20Hz bandpass filtering is carried out to EEG data Po after EEG data Pr before stimulating and stimulation respectively, to deserved
To filtered data: Pr_f and Po_f；
(2) data Pr_f is divided into every 20 seconds one section of data segments, each data Pr_f is divided into 15 segment datas, according to quick
Fourier transformation calculates the power of the β wave of the δ wave of the 2-4Hz in every segment data, the θ wave of 4-8Hz and 12-18Hz, by 15 number of segment
The absolute power level of wave band is corresponded to respectively as data Pr_f according to resulting δ popin mean value, θ popin mean value and β popin mean value:
Pr_power_ δ, Pr_power_ θ and Pr_power_ β；Data Po_f is divided into every 20 seconds one section of data segments, each number
Be divided into 15 segment datas according to Po_f, according to Fast Fourier Transform (FFT) calculate the δ wave of the 2-4Hz in every segment data, 4-8Hz θ wave and
The power of the β wave of 12-18Hz, using the resulting δ popin mean value of 15 segment datas, θ popin mean value and β popin mean value as data
Po_f corresponds to the absolute power level of wave band: Po_power_ δ, Po_power_ θ and Po_power_ β；
(3) according to the following formula, difference power Δ δ, Δ θ, the Δ β of each lead in stimulation front and back are calculated separately:
(4) calculate separately according to the following formula each lead brain electrical activation exponent gamma _ F3, γ _ FP1, γ _ F7, γ _ FT7, γ _
FC3、γ_FCZ、γ_FZ、γ_T3、γ_C3、γ_CZ、γ_FC4、γ_F4、γ_FP2、γ_F8、γ_FT8、γ_T4
+ 0.5 Δ β (4) of+0.9 Δ θ of γ _ Y=0.6 Δ δ
Wherein, Y be corresponding lead F3, FP1, F7, FT7, FC3, FCZ, FZ, T3, C3, CZ, FC4, F4, FP2, F8, FT8 and
T4；
(5) weight is respectively set to each of 16 leads lead, weight is divided into 0.5,0.3,0.15,0.05 4 etc.
Grade, wherein the lead under 0.5 weight are as follows: F3；Lead under 0.3 weight are as follows: FP1, F7, FT7, FC3, FCZ, FZ；0.15 weight
Under lead are as follows: T3, C3, CZ, FC4, F4；Lead under 0.05 weight are as follows: FP2, F8, FT8, T4 are used for according to the following formula
The excitatoty full brain brain of assessment cerebral cortex after cranium galvanic current stimulation electrically activates exponent gamma:
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| CN111281379A (en) * | 2020-03-02 | 2020-06-16 | 清华大学 | Method and device for improving attention span through transcranial direct current stimulation |
| CN114081512A (en) * | 2021-12-20 | 2022-02-25 | 天津大学 | Method for evaluating influence degree of transcranial direct current stimulation on brain auditory processing capacity |
| CN114259239A (en) * | 2020-09-15 | 2022-04-01 | 洪硕宏 | Auxiliary judgment device for evaluating whether transcranial magnetic stimulation is effective for melancholia patient |
| CN115644890A (en) * | 2022-11-15 | 2023-01-31 | 南京左右脑医疗科技集团有限公司 | Brain state recognition method, device and storage medium |
| CN116570834A (en) * | 2023-07-12 | 2023-08-11 | 杭州般意科技有限公司 | Transcranial direct current stimulation method, device, terminal and medium |
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