CN110236482A - Integrated eye brain visual performance imaging system - Google Patents
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- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
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- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
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Abstract
The invention discloses a kind of integrated eye brain visual performance imaging systems, comprising: picture and video comprising a variety of Induced by Stimulation normal forms is presented in visual stimulus display device；Eye visual imaging device is based on multispectral retina and pupil image equipment；Brain vision imaging apparatus is the vision cortex blood flow signal imaging device based on nearly red diffusion Correlation Spectroscopy；Cooperate station, including imaging acquisition control module and image analysis module, for Collaborative Control eye visual imaging device and brain vision imaging apparatus, and multispectral retina, pupil image and the vision cortex blood-stream image that will acquire are handled and are analyzed.It can be realized the synchronous recording of ophthalmic retina, pupil and the response of brain visual cortex nervous function by the system, Conjoint Analysis is carried out to the vision physiological signal of multi-modal multi-parameter, is the providing methods such as visual information encoding and decoding, optical rehabilitation mechanism study, the impaired positioning of optic nerve regulation qualitative assessment.
Description
Technical field
The present invention relates to medical imaging techniques fields, more particularly to a kind of integrated eye brain visual performance imaging system
System.
Background technique
Due to the importance of visual performance, the research in terms of optic nerve function both at home and abroad is always a hot spot.Big
In terms of brain optic nerve functional imaging, the common functional magnetic resonance imager of equipment (fMRI), electroencephalograph (EEG), near-infrared
Cerebral function imaging instrument (fNIRS).The principle of fMRI is the blood for measuring neuron activity using dynamic magnetic resonance imaging and being caused
The change of oxygen level.The functional localization to human visual system's correlation cortex is able to achieve with fMRI, color identifies, vision adds
The research of work etc. is not capable of measuring instantaneous brain neurological motion variation however, the temporal resolution of fMRI is lower.EEG can detecte
Cerebral nerve activity generate electric signal, but EEG measurement be head surface electric signal, due to the electrical conduction of brain neurological motion
The influence that will receive head tissue, the EEG signal for measuring space can deviate true encephalic cranial nerve telecommunications to a certain extent
Number, therefore usually require the accurate positionin that joint dysfunction magnetic resonance imaging is just able to achieve cerebration.FNIRS to existing fMRI,
EEG technology is a very useful supplement, is a kind of near infrared light by safety to assess cerebral cortex oxygenated blood red eggs
The functional near infrared light Brian Imaging system of white and deoxy hemoglobin components variation, but due to fNIRS measurement be slowly to become
The blood oxygen metabolism activity of change, therefore still it is unable to accurate recording nervous activity process.
In terms of eye visual nervous function imaging, common equipment has means of optical coherence tomography (OCT), eyeground
Mirror, iris corder.OCT is non-contact one kind, high-resolution chromatography and biomicroscope imaging device, it can be used for posterior segment structure
It is checked on the living body of (including retina, retinal nerve fibre layer, macula lutea and optic disk), axial tomography and measurement, is special
As the diagnostic device for helping testing and management eye illness.Ophthalmoscope is mainly used for eye ground imaging, and ophthalmoscope not only can be with
For the ophthalmology diseases inspection such as common cataract, and the whole body systems such as hypertension, diabetes can be early diagnosed
Disease has become the popular object of clinical medicine and modern scientific research.Iris corder is mainly used for pupillary light reflex, pupil
The fields such as block, nystagmus measurement and eye-tracking, in addition, the fine registration core group of itself or a variety of ophthalmological instruments
Part.But these equipment only limit and are used for static ocular imaging, continuous, dynamically eye can not be imaged, also, nothing
The complete neural circuit of method quantitative measurement pupillary light reflex.
It to sum up analyzes, to optic nerve functional imaging is all at present that a variety of imagings or are used using a kind of imaging device
Equipment timesharing, Divisional are imaged optic nerve function, and are analyzed on this basis.Wherein, to retina neural
The movable monitoring of member is mostly carried out based on mode that is intrusive or measuring in vitro；And currently to the research on eyeground mostly just for retina
And the obvious lesion of periphery blood vessel structure, still lack to the neururgic detection means in living body eyeground.However, vision processing be from
The dynamic neural of ophthalmic retina to brain visual cortex reacts, and the simple combination of existing equipment can not be to ophthalmic retina and big
The dynamic neural reaction of brain visual cortex carries out instantaneous, dynamic functional imaging.This technology is capable of providing a kind of while to eye
The method that retina and brain visual cortex function carry out living imaging, it is same that development can be used for simultaneously retina-visual cortex
The equipment for walking functional imaging is asked for clinics such as research optical rehabilitation mechanism, optic nerve regulation qualitative assessment, positioning visually impaired
Topic provides new method, has important scientific research value and clinical value.
Summary of the invention
The present invention solves the technical problem of the simple combinations of currently existing equipment can not be to ophthalmic retina and big
The problem of dynamic neural reaction of brain visual cortex carries out instantaneous, dynamic functional imaging.
In order to solve the above technical problems, the technical solution adopted by the present invention is that: a kind of integrated eye brain vision function is provided
Energy imaging system, the system comprises:
Visual stimulus display device, the visual stimulus display device are picture and view comprising a variety of Induced by Stimulation normal forms
Frequency display device；
Eye visual imaging device, the eye visual imaging device are based on multispectral ophthalmic retina and pupillogram
As acquisition；
Brain vision imaging apparatus, the brain vision imaging apparatus are the visions based on near-infrared diffusion Correlation Spectroscopy
The acquisition of cortex blood flow signal；
Cooperate station, and the collaborative work station includes imaging acquisition control module and image analysis module, for cooperateing with
The multispectral eyes image that controls the eye visual imaging device and the brain vision imaging apparatus, and will acquire
Data processing is carried out with the vision cortex blood flow signal.
Preferably, visual stimulus display device includes the picture and video of a variety of Induced by Stimulation normal forms, and keep with
The time consistency of ocular imaging equipment and brain imaging equipment.
Preferably, the eye visual imaging device includes multispectral light source module, picture signal acquisition and control mould
Block, image capture module and multispectral light source control module.
Preferably, described image acquisition module includes collimation lens, hollow reflective mirror, the first plus lens, the second remittance
Poly- lens, pupil camera and retina camera；The light that the multispectral light source module issues quilt after collimation lens collimation
The hollow reflective mirror reflection, then transmits pupil and retina that first plus lens is irradiated to human eye；Pupillary reflex
Light enter the pupil camera, the light of retinal reflex transmits first plus lens, then passes through described hollow
Second plus lens is transmitted again in the middle part of reflecting mirror, reaches the retina camera.
Preferably, the multispectral light source control module includes multispectral control unit, a key acquisition unit and environment
Light control unit.
Preferably, the visual stimulus display device includes left stimulation display module and right stimulation display module.
Preferably, the brain vision imaging apparatus includes brain blood flow acquisition module and data processing module, described
Brain blood flow acquisition module includes multiple light sources and several probes, and the multiple light source and several described probes form brain blood
Signal sampling channel is flowed, the data processing module is used for the collected signal of signal of brain's blood stream acquisition module
The quantizating index of the vision cortex blood flow signal is obtained after reason.
Preferably, the signal of brain's blood stream acquisition module is Image Acquisition cap, the multiple light source and several probes
It is acquired on cap around described image is distributed in.
Preferably, the light source is near-infrared laser light source；The light source includes 4, and the probe includes 16.4
A light source and 16 probes form 20 eeg signal acquisition channels.
Preferably, the probe includes near infrared laser, single-photon detector and single mode/multimode fibre.
Preferably, collaborative work station includes imaging acquisition control module and visual imaging analysis module, it is described at
As acquisition control module is for ocular imaging equipment and the brain vision imaging apparatus described in Collaborative Control, the visual imaging
Analysis module extracts cerebral function imaging space characteristics by functional MRI, in conjunction with the multispectral eyes image and
The vision cortex blood flow signal carries out multi-modal spectral clustering analysis.
The beneficial effects of the present invention are: be in contrast to the prior art, the present invention by integrated nervous function at
As system, using medical optical technology, while the optic nerve active signal of eye and brain is acquired, provided more comprehensively abundant
Optic nerve Function detection information；Meanwhile the application is based on the movable dynamic multi-optical spectrum imaging technology of eye optic nerve and is based on
The visual cortex brain Electrical imaging technology of near infrared spectrum can be realized living imaging；The application is also using the station that cooperates to one
The multispectral eyes image and vision cortex blood flow signal of acquisition carry out polymorphic spectral clustering analysis and image reconstruction, so as to
More accurate diseases analysis is provided.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of integrated one embodiment of eye brain visual performance imaging system of the invention；
Fig. 2 is the structural schematic diagram of eye visual imaging device in Fig. 1；
Fig. 3 is the light channel structure schematic diagram of image capture module in Fig. 2；
Fig. 4 is the structural schematic diagram of Fig. 1 brain vision imaging apparatus；
Fig. 5 is the structural schematic diagram at Fig. 1 collaborative work station；
Fig. 6 is that visual imaging analysis module extracts cerebral function imaging space characteristics to functional MRI in Fig. 4
Algorithm flow schematic diagram.
Specific embodiment
To make those skilled in the art more fully understand technical solution provided by the present invention, with reference to the accompanying drawing and have
A kind of integrated eye brain visual performance imaging system provided by the present invention is described in detail in body embodiment.
Referring to Fig. 1, one embodiment of present invention integration eye brain visual performance imaging system, including visual stimulus is in
Existing equipment 10, eye visual imaging device 11, brain vision imaging apparatus 12 and the station 13 that cooperates.
Specifically, in visual stimulus display device 10 include the picture and video of a variety of Induced by Stimulation normal forms, and keep
With the time consistency of ocular imaging equipment and brain imaging equipment.The visual stimulus display device 10 is shown including left stimulation
Module and right stimulation display module.For providing visual stimulus to the left eye of user and right eye respectively, pupil image is by eye
Pupil camera 1145 in vision imaging apparatus 11 acquires.
Eye visual imaging device 11 is the multispectral eyes image acquisition based on dynamic vision stimulation.Eye visual imaging
Equipment is for acquiring pupil of human image and retinal images.
Currently mainly there are OCT, ophthalmoscope, iris corder to the equipment of eye visual nervous function imaging.OCT, which is that one kind is non-, to be connect
Touching, high-resolution chromatography and biomicroscope imaging device.It can be used for posterior segment structure (including retina, retina neural
Fibrous layer, macula lutea and optic disk) living body on check, axial tomography and measurement, be to be particularly useful as helping testing and management eye illness
(including but not limited to macula hole, macular cystoid edema, diabetic retinopathy, senile macular degeneration and glaucoma)
Diagnostic device.The equipment mainly utilizes absorption of oxygen-containing contained by the different tissues of the eyeground/deoxyhemoglobin to different spectrum
Difference carries out accurately image to different tissues.Since neuron activity can cause regional flow/blood oxygen variation, it is based on
The multi-optical spectrum imaging technology of OCT potentially contributes to measure eyeground nervous activity.Ophthalmoscope is mainly used for eye ground
Imaging, ophthalmoscope not only can be for ophthalmology diseases inspections such as common cataracts, but also can early diagnose high blood
The whole body systems disease such as pressure, diabetes has become the popular object of clinical medicine and modern scientific research.Iris corder is main
For fields such as pupillary light reflex, pupil block, nystagmus measurement and eye-trackings, in addition, itself or a variety of ophthalmology
The fine registration core component of instrument.But these equipment only limit and are used for static ocular imaging, it can not be continuous, dynamically right
Eye is imaged, also, without the complete neural circuit of method quantitative measurement pupillary light reflex.
For this problem, the present invention is creatively proposed based on multispectral eye visual imaging device 11, can be utilized
Different spectrum monitoring ophthalmic retina optic nerve activity such as blood oxygen saturations etc. cause optical property variation realize dynamic eyeground and
Pupillary function imaging.
Brain vision imaging apparatus 12 is the vision cortex blood flow signal acquisition based near infrared spectrum.Vision herein
Cortex blood flow signal is chosen as vision cortex blood flow signal.Cerebral cortex blood flow is monitored using the stimulation of near infrared spectrum
Amount.
Above-mentioned eye visual imaging device 11 is chosen as eyeshade formula form, and brain vision imaging apparatus 12 is chosen as smearing volume shape
Formula or cap form, the two integration of equipments are integrated, and can reduce volume, easy to carry.
Cooperate station 13, and the station 13 that cooperates is imaged for Collaborative Control eye visual imaging device 11 and eye visual
Equipment 12, and the multispectral eyes image and vision cortex blood flow signal that will acquire carry out data processing.
Station 13 cooperate based on different goals in research, need to consider a variety of Induced by Stimulation normal forms and induces presentation side
Formula, and keep the time consistency of stimulation with imaging.It includes multispectral eyes image and view that collaborative work station 13 was handled, which is,
Feel cortex blood flow signal including compound optic nerve active signal, it is therefore desirable to complete collaboration light source 1211 control,
The functions such as data acquisition, data transmission, data processing, need to eye visual imaging device 11, eye visual imaging device 12
Multi-modal, multichannel each functional component coordinated, be the collaboration hinge of whole system.Collaborative work station 13 will also be responsible for
Eyeground, the data processing works such as positioning, registration, fusion of pupil, vision cortex blood flow signal and complexity functional analysis,
The work such as record and storage.
By the above-mentioned means, can be realized integrated eye brain neuroblastoma functional imaging, while collected multispectral eye
Portion's image (retinal images and pupil image) and vision cortex blood flow signal are capable of providing optic nerve more comprehensively abundant
Function detection information can significantly improve the reliability and timeliness of disease early diagnosis based on spatial registration and special algorithm.
Referring to Fig. 2, the eye visual imaging device 11 includes multispectral light source module 113, picture signal acquisition and control
Molding block 111, image capture module 114 and multispectral light source control module 112.
Referring to Fig. 3, described image acquisition module includes that collimation lens 1141, the convergence of hollow reflective mirror 1142, first are saturating
Mirror 1143, the second plus lens 1144, pupil camera 1145 and retina camera 1146；What the multispectral light source module issued
Light is reflected after the collimation lens 1141 collimation by the hollow reflective mirror 1142, then transmits first plus lens
1143 are irradiated to the pupil and retina of human eye；The light of pupillary reflex enters the pupil camera 1145, retinal reflex
Light transmits first plus lens 1143, then passes through 1142 middle part of hollow reflective mirror and transmits second convergence again
Lens 1144 reach the retina camera 1146.Collimation lens 1141, hollow reflective mirror 1142, the first plus lens 1143,
Second plus lens 1144 can be integrally disposed in optical lens.Gap is set in the middle part of hollow reflective mirror 1142, it is anti-for retina
Light is penetrated to pass through.The pupil image of human eye is acquired by pupil camera 1145, and retinal images are adopted by retina camera 1146
Collection.
Above-mentioned multispectral light source control module 111 may also include multispectral control unit, a key acquisition unit and environment light
Control unit, multispectral control unit control issue the one-wavelength laser of different wave length.One key acquisition unit carries out one key of image and adopts
Collection, environment light control unit is for controlling environment bias light.
In another specific embodiment of the present invention, eye visual imaging device 11 may also include display device, can
Convenient for showing and observing the image of acquisition, display device is chosen as liquid crystal display.
The eye visual imaging device 11 can read its collection result with requesting cooperative work station 13, eye visual imaging
Data communication between equipment 11 and the station 13 that cooperates selects USB, PCI-E transmission mode based on bus.
As shown in figure 4, brain vision imaging apparatus 12 includes electroencephalogramsignal signal acquisition module 121 and data processing module 122,
Electroencephalogramsignal signal acquisition module 121 includes multiple light sources 1211 and several probes 1212, and multiple light sources 1211 are popped one's head in several
1212 form eeg signal acquisition channel, and data processing module 122 is used for the collected signal of electroencephalogramsignal signal acquisition module 121
Vision cortex blood flow signal is obtained after being handled.Wherein, light source 1211 is near-infrared light source.
Wherein, electroencephalogramsignal signal acquisition module 121 is Image Acquisition cap, and multiple light sources 1211 and several probes 1212 are surround
It is distributed on Image Acquisition cap, multiple light sources 1211 are chosen as 4 light sources 1211, several probes 1212 are chosen as 16 probes
1212,4 light source 1211 and 16 probes 1212 form 20 eeg signal acquisition channels.
Each light source 1211 is preferably near-infrared laser light source.Also it is chosen as near-infrared LED light source.
The probe 1212 includes near infrared laser, single-photon detector and single mode/multimode fibre.It can swash relevant
Light irradiation is lower to realize high speed, the acquisition of accurate cerebral cortex blood flow signal data, and above-mentioned optical fiber is chosen as single mode optical fiber.
As shown in figure 5, the station 13 that cooperates includes imaging acquisition control module 131 and visual imaging analysis module 132, at
As acquisition control module 131 is used for Collaborative Control ocular imaging system and eye visual imaging device 12, visual imaging analysis mould
Block 132 extracts cerebral function imaging space characteristics, in conjunction with multispectral eye by choosing functional mri from video library
Image and vision cortex blood flow signal carry out multi-modal spectral clustering analysis.
It can be realized the one of eye and brain optic nerve functional imaging acquisition system using imaging acquisition control module 131
Bodyization control, so as to obtain multi-modal eyes image and brain electrical signals, these images and signal reflect retina
With nervous activity situation of the cerebral cortex under visual stimulus induction.Due to the multispectral eyes image of dynamic, near-infrared vision brain
Cortex blood flow signal acquires on different location respectively, in order to construct 3D vision conduction model, needs to carry out vision brain
The multi-modal clustering of cortex blood flow signal, the multispectral eyes image of dynamic.
By the multi-modal deep enough correlation excavated between multi-modal information of clustering energy, to inquire into and inferring vision
View, the brain science mechanism of nervous function provide reference frame.
Specifically, as shown in fig. 6, first have to using visual imaging analysis module 132 is chosen from video library function magnetic be total to
Shake image, forms encephalic image outside Brain Tissues Image and scalp cranium after carrying out three layers of segmentation to functional MRI.To brain group
Knit image carry out cerebellum removal after formed cerebral tissue image, to cerebral tissue image carry out tissue segmentation after formed grey matter,
White matter, cerebrospinal fluid image form function brain area image after carrying out brain area segmentation to cerebral tissue image, to grey matter, white matter, brain ridge
Liquid image and function brain area image form cortex surface image after carrying out resurfacing and brain area division；To encephalic outside scalp cranium
In conjunction with brain area reconstruction image is formed after cortex surface image after image progress eye segmentation, complete to cerebral function imaging space
The extraction of feature.
It is then based on specific visual experiment normal form, by investigating the position and light levels that stimulation is presented, determines view
The local receptor field of film nerve fiber, and multispectral eyes image and vision cortex blood flow letter according further to synchronous acquisition
Number, receptive field hierarchical model between the two is established, and according to this model, deeply investigates different visual signatures and processed in human brain vision
In sensitivity, construct quantifiable stimulation-nerves reaction model.
It can be realized the early diagnosis and quickly identification of disease by constructing model analysis, improve the reliable of medical diagnosis on disease
Property.
In embodiment provided by the present invention, it should be understood that disclosed system, device and method, Ke Yitong
Other modes are crossed to realize.For example, device embodiments described above are only schematical, for example, the module or
The division of unit, only a kind of logical function partition, there may be another division manner in actual implementation, such as multiple units
Or component can be combined or can be integrated into another system, or some features can be ignored or not executed.Another point, institute
Display or the mutual coupling, direct-coupling or communication connection discussed can be through some interfaces, device or unit
Indirect coupling or communication connection can be electrical property, mechanical or other forms.
The unit as illustrated by the separation member may or may not be physically separated, aobvious as unit
The component shown may or may not be physical unit, it can and it is in one place, or may be distributed over multiple
In network unit.Some or all of unit therein can be selected to realize present embodiment scheme according to the actual needs
Purpose.
In addition, each functional unit in each embodiment of the present invention can integrate in one processing unit, it can also
To be that each unit physically exists alone, can also be integrated in one unit with two or more units.It is above-mentioned integrated
Unit both can take the form of hardware realization, can also realize in the form of software functional units.
If the integrated unit is realized in the form of SFU software functional unit and sells or use as independent product
When, it can store in a computer readable storage medium.Based on this understanding, technical solution of the present invention is substantially
The all or part of the part that contributes to existing technology or the technical solution can be in the form of software products in other words
It embodies, which is stored in a storage medium, including some instructions are used so that a computer
It is each that equipment (can be personal computer, server or the network equipment etc.) or processor (processor) execute the present invention
The all or part of the steps of embodiment the method.And storage medium above-mentioned includes: USB flash disk, mobile hard disk, read-only memory
(ROM, Read-Only Memory), random access memory (RAM, Random Access Memory), magnetic or disk
Etc. the various media that can store program code.
Mode the above is only the implementation of the present invention is not intended to limit the scope of the invention, all to utilize this
Equivalent structure or equivalent flow shift made by description of the invention and accompanying drawing content, it is relevant to be applied directly or indirectly in other
Technical field is included within the scope of the present invention.
Claims (10)
1. a kind of integration eye brain visual performance imaging system, which is characterized in that the system comprises:
Visual stimulus display device, the visual stimulus display device is the picture comprising a variety of Induced by Stimulation normal forms and video is in
Existing equipment；
Eye visual imaging device, the eye visual imaging device are adopted based on multispectral ophthalmic retina and pupil image
Collection；
Brain vision imaging apparatus, the brain vision imaging apparatus are the vision brain skins based on near-infrared diffusion Correlation Spectroscopy
Layer blood flow signal acquisition；
Cooperate station, and the collaborative work station includes imaging acquisition control module and image analysis module, is used for Collaborative Control
The eye visual imaging device and the brain vision imaging apparatus, and the multispectral eyes image that will acquire and institute
It states vision cortex blood flow signal and carries out data processing.
2. system according to claim 1, which is characterized in that the eye visual imaging device includes multispectral light source mould
Block, picture signal acquisition and control module, image capture module and multispectral light source control module.
3. system according to claim 1, which is characterized in that described image acquisition module includes collimation lens, hollow anti-
Penetrate mirror, the first plus lens, the second plus lens, pupil camera and retina camera；What the multispectral light source module issued
Light is reflected after collimation lens collimation by the hollow reflective mirror, then transmits first plus lens and is irradiated to human eye
Pupil and retina；The light of pupillary reflex enters the pupil camera, and the light transmission described first of retinal reflex converges
Poly- lens then pass through and transmit second plus lens again in the middle part of the hollow reflective mirror, reach the retina camera.
4. system according to claim 3, which is characterized in that the multispectral light source control module includes multispectral control
Unit, a key acquisition unit and environment light control unit.
5. system according to claim 1, which is characterized in that the visual stimulus display device includes that left stimulation shows mould
Block and right stimulation display module.
6. system according to claim 1, which is characterized in that the brain vision imaging apparatus includes brain blood flow number acquisition
Module and data processing module, the brain blood flow acquisition module include multiple light sources and several probes, the multiple light source
Signal of brain's blood stream acquisition channel is formed with several described probes, the data processing module is for adopting the signal of brain's blood stream
The collection collected signal of module obtains the quantizating index of the vision cortex blood flow signal after being handled.
7. system according to claim 8, which is characterized in that the signal of brain's blood stream acquisition module is Image Acquisition cap,
The multiple light source and several probes acquire on cap around described image is distributed in.
8. system according to claim 7, which is characterized in that the light source is near-infrared laser light source；The light source packet
4 are included, the probe includes 16.
9. system according to claim 8, which is characterized in that the probe includes near infrared laser, single photon detection
Device and single mode/multimode fibre.
10. system according to claim 1, which is characterized in that the collaborative work station includes imaging acquisition control module
With visual imaging analysis module, the imaging acquisition control module is for ocular imaging equipment and the brain described in Collaborative Control
Vision imaging apparatus, the visual imaging analysis module extract cerebral function imaging space characteristics by functional MRI,
Multi-modal spectral clustering analysis is carried out in conjunction with the multispectral eyes image and the vision cortex blood flow signal.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812707A (en) * | 2019-11-25 | 2020-02-21 | 北京师范大学 | Brain imaging and light nerve regulation and control integrated device |
| CN112641450A (en) * | 2020-12-28 | 2021-04-13 | 中国人民解放军战略支援部队信息工程大学 | Time-varying brain network reconstruction method for dynamic video target detection |
| CN112674752A (en) * | 2020-12-30 | 2021-04-20 | 深圳市联影高端医疗装备创新研究院 | Functional magnetic resonance imaging method, device, equipment and storage medium |
| CN113406663A (en) * | 2021-06-17 | 2021-09-17 | 王高 | Visual imaging system and method based on P300 and associated imaging |
| CN114601430A (en) * | 2022-03-23 | 2022-06-10 | 浙江大学 | Cortex function connection positioning device based on near-infrared light stimulation |
| CN116186502A (en) * | 2023-04-27 | 2023-05-30 | 华南理工大学 | Multi-mode visual nerve function detection method and system thereof |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008086412A (en) * | 2006-09-29 | 2008-04-17 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | Retina image data acquisition/display device and retina image data acquisition/displaying method |
| JP2010233978A (en) * | 2009-03-31 | 2010-10-21 | Nidek Co Ltd | Visual performance inspection device |
| CN102499635A (en) * | 2011-10-26 | 2012-06-20 | 中国科学院光电技术研究所 | Line scanning-based fundus retina multispectral imaging system and method |
| CN102657515A (en) * | 2012-05-10 | 2012-09-12 | 中国科学院长春光学精密机械与物理研究所 | Alignment light path device applied to retinal imaging system |
| CN205625890U (en) * | 2016-03-29 | 2016-10-12 | 孙明斋 | High spectrum eye ground imaging system |
| CN108670192A (en) * | 2018-04-21 | 2018-10-19 | 重庆贝奥新视野医疗设备有限公司 | A kind of multispectral eyeground imaging system and method for dynamic vision stimulation |
| CN108882875A (en) * | 2015-12-14 | 2018-11-23 | 奥托-冯-格里克-马格德堡大学 | Equipment for neural blood vessel stimulation |
| CN109431457A (en) * | 2018-12-21 | 2019-03-08 | 合肥奥比斯科技有限公司 | Multispectral eyeground imaging system |
| CN211704590U (en) * | 2019-05-31 | 2020-10-20 | 中国科学院苏州生物医学工程技术研究所 | Integrated eye and brain visual function imaging system |
-
2019
- 2019-05-31 CN CN201910471543.4A patent/CN110236482B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008086412A (en) * | 2006-09-29 | 2008-04-17 | Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai | Retina image data acquisition/display device and retina image data acquisition/displaying method |
| JP2010233978A (en) * | 2009-03-31 | 2010-10-21 | Nidek Co Ltd | Visual performance inspection device |
| CN102499635A (en) * | 2011-10-26 | 2012-06-20 | 中国科学院光电技术研究所 | Line scanning-based fundus retina multispectral imaging system and method |
| CN102657515A (en) * | 2012-05-10 | 2012-09-12 | 中国科学院长春光学精密机械与物理研究所 | Alignment light path device applied to retinal imaging system |
| CN108882875A (en) * | 2015-12-14 | 2018-11-23 | 奥托-冯-格里克-马格德堡大学 | Equipment for neural blood vessel stimulation |
| CN205625890U (en) * | 2016-03-29 | 2016-10-12 | 孙明斋 | High spectrum eye ground imaging system |
| CN108670192A (en) * | 2018-04-21 | 2018-10-19 | 重庆贝奥新视野医疗设备有限公司 | A kind of multispectral eyeground imaging system and method for dynamic vision stimulation |
| CN109431457A (en) * | 2018-12-21 | 2019-03-08 | 合肥奥比斯科技有限公司 | Multispectral eyeground imaging system |
| CN211704590U (en) * | 2019-05-31 | 2020-10-20 | 中国科学院苏州生物医学工程技术研究所 | Integrated eye and brain visual function imaging system |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110812707A (en) * | 2019-11-25 | 2020-02-21 | 北京师范大学 | Brain imaging and light nerve regulation and control integrated device |
| CN110812707B (en) * | 2019-11-25 | 2021-05-18 | 北京师范大学 | Brain imaging and light nerve regulation and control integrated device |
| CN112641450A (en) * | 2020-12-28 | 2021-04-13 | 中国人民解放军战略支援部队信息工程大学 | Time-varying brain network reconstruction method for dynamic video target detection |
| CN112674752A (en) * | 2020-12-30 | 2021-04-20 | 深圳市联影高端医疗装备创新研究院 | Functional magnetic resonance imaging method, device, equipment and storage medium |
| CN113406663A (en) * | 2021-06-17 | 2021-09-17 | 王高 | Visual imaging system and method based on P300 and associated imaging |
| CN113406663B (en) * | 2021-06-17 | 2024-03-12 | 王高 | Visual imaging system and method based on P300 and associated imaging |
| CN114601430A (en) * | 2022-03-23 | 2022-06-10 | 浙江大学 | Cortex function connection positioning device based on near-infrared light stimulation |
| CN114601430B (en) * | 2022-03-23 | 2024-02-20 | 浙江大学 | Cortex function connection positioning device based on near infrared light stimulation |
| CN116186502A (en) * | 2023-04-27 | 2023-05-30 | 华南理工大学 | Multi-mode visual nerve function detection method and system thereof |
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