CN102793973B - Device for treating Parkinson's disease - Google Patents
Device for treating Parkinson's disease Download PDFInfo
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- CN102793973B CN102793973B CN201210275424.XA CN201210275424A CN102793973B CN 102793973 B CN102793973 B CN 102793973B CN 201210275424 A CN201210275424 A CN 201210275424A CN 102793973 B CN102793973 B CN 102793973B
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Abstract
The invention relates to a device for treating Parkinson's disease. The device comprises an electrophysiological signal generation detecting system, a drug delivery system, a photostimulation system, and a central processing system. The central processing system controls the electrophysiological signal generation detecting system, the drug delivery system, and the photostimulation system. The electrophysiological signal generation detecting system comprises a neurotransmitter sensor, a recording electrode, and a stimulating electrode. The drug delivery system comprises a syringe pump and a micro-catheter. The central processing system controls the syringe pump to perform drug slow release through the micro-catheter. The photostimulation system comprises a waveform generator, a light source and optical fibers. The waveform generator controls frequency of laser emitted by the light source. The laser emitted by the light source is transmitted to the optical fibers and is used for photostimulation treatment on imported nervous tissue cells with photaesthesia genes. A device for treating the Parkinson's disease is provided, and the device has relatively good monitoring and treating effects and is relatively safe.
Description
Technical field
The present invention relates to medical instruments field, particularly relate to a kind of parkinson therapy equipment.
Background technology
Parkinson (Parkinson's disease) is the common central nervous system degenerative disease of a kind of middle-aged and elderly people, how at 60 years old with sequela, it is slow that main disease shows as patient motion, trembling of trick or health other parts, health loses flexibility, become stiff, can cause late period patient can't take care of oneself, bring larger burden to patient and family members.In addition,, along with population in the world is gradually to aging transition, the nervous system disease showed increased such as parkinson also become a great society burden gradually.
In recent years, neuroregulation treatment is rapidly developed in the application of the nervous system disease such as treatment parkinson, develop at present multiple neuroregulation Therapeutic Method, such as repetitive transcranial magnetic stimulation, through cranium stimulus of direct current and dark electrical brain stimulation etc., wherein, dark electrical brain stimulation therapy is one of at present comparatively desirable neuroregulation Therapeutic Method.
Dark electrical brain stimulation has certain therapeutic effect, but also there are many deficiencies: first, dark electrical brain stimulation lacks selectivity and specificity, and also indefinite for the mechanism for the treatment of in many cases, therefore, in the process stimulating, there is certain unpredictability, even may have side effects.Secondly, stimulating apparatus is after long-term implantation, and because the wound of operation and the biocompatibility issues of embedded material tend to cause inflammatory reaction, along with the formation of astrocyte encapsulation, the impedance meeting of electrode interface obviously increases, and effect of stimulation significantly weakens.In addition, encapsulation also can affect the Neuronal Survival of electrode perimeter, has increased the distance of electrode and target nerve unit, and then has a strong impact on the therapeutic effect of dark electrical brain stimulation.In addition, the dark more difficult realization of electrical brain stimulation is to neuronic inhibition.
Summary of the invention
Based on this, be necessary to provide a kind of monitoring and the better and safer parkinson therapy equipment of therapeutic effect.
A kind of parkinson therapy equipment, comprise electricity physiological signal generation detection system, drug-supplying system, light stimulus system and central processing system, electricity physiological signal generation detection system, described drug-supplying system and described light stimulus system described in described central processing system control;
Wherein, described electricity physiological signal generation detection system comprises for detection of the neurotransmitter concentration of target area and the neurotransmitter sensor of variation, stimulating electrode for recording the local field potentials of nervous tissue's cell and the recording electrode of neuroelectricity activity and for carrying out functional electric stimulation, parkinsonian being treated;
Described drug-supplying system comprises syringe pump and microtubular, and syringe pump carries out medicament slow release by microtubular described in described central processing system control;
Described light stimulus system comprises waveform generator, light source and optical fiber, the sharp light frequency that described in described waveform generator control, light source sends, the laser that described light source sends reaches in described optical fiber for having nervous tissue's cell of photaesthesia gene to carry out photostimulation treatment to importing.
In an embodiment, described neurotransmitter sensor is carbon fiber microelectrodes with micro pipette tips, platinum microelectrode, platinoiridita microelectrode, iridium microelectrode, CNT microelectrode or conducting polymer microelectrode therein, and the diameter of described neurotransmitter sensor is 3～200 microns.
In an embodiment, described neurotransmitter sensor, described recording electrode and described stimulating electrode form electrod-array therein.
In an embodiment, the quantity of described neurotransmitter sensor, the quantity of described stimulating electrode, the quantity of described recording electrode, the quantity of described microtubular and the quantity of described optical fiber are at least respectively 1 therein.
In an embodiment, described electrod-array, described microtubular and described optical fiber be arranged in parallel and are combined together to form fascicular texture therein.
In an embodiment, described drug-supplying system discharges light sensation gene, the anti-inflammatory factor, neurotrophic factor or angiogenesis factor by microtubular neurad histiocyte therein.
In an embodiment, the sharp light wavelength that described light source sends is 472nm or 593nm therein.
In an embodiment, described neurotransmitter is at least one in dopamine and glutamic acid therein.
When above-mentioned parkinson therapy equipment work, first central processing system control electricity physiological signal generation detection system detects concentration and the variation of neurotransmitter by neurotransmitter sensor, detect the electricity physiological signal of nervous tissue's cell by recording electrode simultaneously, thereby can better monitor disease, central processing system regulates the laser of light source output different frequency according to feedack control waveform signal generator, the laser that light source sends reaches in optical fiber for having nervous tissue's cell of photaesthesia gene to carry out photostimulation treatment to importing.Carry out excited or inhibitory neuron by photostimulation, reach the object of regulation and control neural circuit, thereby reach the parkinsonian object for the treatment of, and laser only there is effect to the nervous tissue's cell that has imported sensitization gene, therefore, this parkinson therapy equipment has selectivity and specificity.And this device has been integrated stimulating electrode and drug-supplying system, can in the process for the treatment of, improve therapeutic effect and safer in conjunction with electricity irritation and medicament slow release technology as supplementary means.
Brief description of the drawings
Fig. 1 is the module diagram of the parkinson therapy equipment of an embodiment;
Fig. 2 is the structural representation of electrod-array, microtubular and optical fiber in Fig. 1.
Detailed description of the invention
Below in conjunction with accompanying drawing, to parkinson, therapy equipment is further described.
As shown in Figure 1, the parkinson therapy equipment 100 of an embodiment, for nervous tissue 200 is carried out to test-and-treat, it comprises central processing system 110, electricity physiological signal generation detection system 120, drug-supplying system 130 and light stimulus system 140.
Central processing system 110 Comprehensive Control electricity physiological signal generation detection systems 120, drug-supplying system 130 and light stimulus system 140.
In the present embodiment, electricity physiological signal generation detection system 120 comprises for detection of the neurotransmitter concentration of target area and the neurotransmitter sensor 122 of variation, stimulating electrode 126 for recording the local field potentials of nervous tissue's cell and the recording electrode 124 of neuroelectricity activity and for carrying out functional electric stimulation, parkinsonian being treated.
Neurotransmitter sensor 122 detects concentration and the change information of neurotransmitter in nervous tissue's 200 cells (as dopamine or glutamic acid).Recording electrode 124 records the electricity physiological signal information (comprising local field potentials and neuroelectricity active signal) of nervous tissue's 200 cells.Neurotransmitter sensor 122 obtains physiological signal with recording electrode 124 by detection and feeds back to central processing system 110, central processing system 110 can be more accurate to the disease judgement of nervous tissue 200 according to multiple monitoring information, can better monitor disease, improve the accuracy for the treatment of.
Central processing system 110 can be controlled stimulating electrode 126 parkinson is carried out to functional electric stimulation treatment, for parkinson provides a kind for the treatment of means.
In the present embodiment, neurotransmitter sensor 122, recording electrode 124 and stimulating electrode 126 form electrod-array.The quantity of neurotransmitter sensor 122, recording electrode 124 and stimulating electrode 126 is respectively 1.
In other embodiments, the quantity of neurotransmitter sensor 122 can be multiple, when specific works, can be that multiple neurotransmitter sensors 122 are monitored same neurotransmitter, can be also multiple neurotransmitter sensor 122 corresponding monitoring neurotransmitter not of the same race.Wherein, neurotransmitter sensor 122 can be one or more in carbon fiber microelectrodes with micro pipette tips, platinum microelectrode, platinoiridita microelectrode, iridium microelectrode, CNT microelectrode or conducting polymer microelectrode, and the diameter of general neurotransmitter sensor 122 is 3～200 μ m.According to different treatment requirements, electrod-array can also be neurotransmitter sensor 122, at least one in stimulating electrode 126 and recording electrode 124, and the quantity of neurotransmitter sensor 122, recording electrode 124 and stimulating electrode 126 all can be not identical, quantity can be one or more according to practical situation.
In the present embodiment, drug-supplying system 130 comprises syringe pump 132 and microtubular 134.Central processing system 110 is controlled syringe pump 132, by microtubular 134, nervous tissue 200 is carried out to medicament slow release.The quantity of the microtubular 134 of present embodiment is 1.In other embodiment, according to practical situation, the quantity of microtubular 134 can be multiple, can carry out the slow release of multi-medicament simultaneously.
In the present embodiment, light stimulus system 140 comprises waveform generator 142, light source 144 and optical fiber 146.The laser of different frequency controlled light source 144 and sends by waveform generator 142.The laser that light source 144 sends reaches in optical fiber 146 for having nervous tissue's 200 cells of photaesthesia gene to carry out photostimulation treatment to importing.The sharp light wavelength that light source sends is 472nm or 593nm.The quantity of optical fiber is 1.In other embodiments, the quantity of optical fiber 146 can be multiple, and multiple optical fiber 146 can be carried out photostimulation treatment to multiple positions of nervous tissue 200 simultaneously.
In the present embodiment, drug-supplying system 130 has the effect of two aspects, be on the one hand: before photostimulation treatment, first organize 200 cells to discharge light sensation genes by drug-supplying system 130 neurads and be transferred to the neuron of associated loop in and express, then cause the excited of target nerve unit or suppress by photostimulation.The photaesthesia gene pairs blueness (wavelength=472nm) importing and yellow (wavelength=593nm) laser are responsive especially.Light source 144 sends blueness or yellow laser is reached in nervous tissue's 200 cells and irradiated by optical fiber 146, blue light stimulates expresses the neuron that has excited type channel protein gene, by such neuron of excitement, wherein, excited type channel protein gene is ChR2 (Channelrhodopsin-2); Express and stimulate with gold-tinted the neuron that has inhibition type channel protein gene, will suppress such neuron, wherein, inhibition type channel protein gene is NpHR (Helorhodopsin).Just can regulate and control neural circuit by excited or inhibition, thereby reach the parkinsonian object for the treatment of.Because blueness or yellow laser only work to the cell that has imported photaesthesia gene, therefore this device has selectivity and specificity, and effectively excitement or inhibitory neuron.
On the other hand, in therapeutic process, due to operation wound and the biocompatibility issues of embedded material tend to cause inflammatory reaction, cause the formation of astrocyte encapsulation and the death of peripheral nerve unit.Like this, will have a strong impact on the effect of electronic stimulation and photostimulation treatment.In the time that inflammatory reaction produces, the information that central processing system 110 obtains according to feedback, control drug-supplying system 130 carries out the release of the anti-inflammatory factor to alleviate inflammatory.In addition, in therapeutic process, the information that central processing system 110 also can obtain according to feedback, the release that control drug-supplying system 130 carries out neurotrophic factor is to promote neural growth and activity, or carry out the release of angiogenesis factor to strengthen the microcirculation of nervous tissue's 200 cell compartments, promote the reparation of nervous tissue 200.
As shown in Figure 2, in the present embodiment, electrod-array, microtubular 134 and optical fiber 146 be arranged in parallel, and form fascicular texture by fixture 300 secure bond together.
When above-mentioned parkinson therapy equipment work, first, central processing system 110 is controlled electricity physiological signal generation detection system 120 and detects by neurotransmitter sensor 122 concentration and the variation of neurotransmitter, detect the electricity physiological signal of nervous tissue's 200 cells by recording electrode 124 simultaneously, better monitoring disease, then, central processing system 110 regulates light source 144 to export the laser of different frequency according to feedack control waveform signal generator 142, the laser that light source 144 sends reaches in optical fiber 146 for having nervous tissue's 200 cells of photaesthesia gene to carry out photostimulation treatment to importing.Carry out excited or inhibitory neuron by photostimulation, reach the object of regulation and control neural circuit, thereby reach the parkinsonian object for the treatment of, and laser only there is effect to the nervous tissue's cell that has imported sensitization gene, therefore, this parkinson therapy equipment has selectivity and specificity.And this device has been integrated stimulating electrode 126 and drug-supplying system 130, can in the process for the treatment of, improve therapeutic effect and safer in conjunction with electricity irritation and medicament slow release technology as supplementary means.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (8)
1. a parkinson therapy equipment, it is characterized in that, comprise electricity physiological signal generation detection system, drug-supplying system, light stimulus system and central processing system, electricity physiological signal generation detection system, described drug-supplying system and described light stimulus system described in described central processing system control;
Wherein, described electricity physiological signal generation detection system comprises for detection of the neurotransmitter concentration of target area and the neurotransmitter sensor of variation, stimulating electrode for recording the local field potentials of nervous tissue's cell and the recording electrode of neuroelectricity activity and for carrying out functional electric stimulation, parkinsonian being treated;
Described drug-supplying system comprises syringe pump and microtubular, and syringe pump carries out medicament slow release by microtubular described in described central processing system control;
Described light stimulus system comprises waveform generator, light source and optical fiber, the sharp light frequency that described in described waveform generator control, light source sends, the laser that described light source sends reaches in described optical fiber for having nervous tissue's cell of photaesthesia gene to carry out photostimulation treatment to importing.
2. parkinson therapy equipment according to claim 1, it is characterized in that, described neurotransmitter sensor is carbon fiber microelectrodes with micro pipette tips, platinum microelectrode, platinoiridita microelectrode, iridium microelectrode, CNT microelectrode or conducting polymer microelectrode, and the diameter of described neurotransmitter sensor is 3 ~ 200 microns.
3. parkinson therapy equipment according to claim 1 and 2, is characterized in that, described neurotransmitter sensor, described recording electrode and described stimulating electrode form electrod-array.
4. parkinson therapy equipment as claimed in claim 3, it is characterized in that, the quantity of described neurotransmitter sensor, the quantity of described stimulating electrode, the quantity of described recording electrode, the quantity of described microtubular and the quantity of described optical fiber are at least respectively 1.
5. parkinson therapy equipment according to claim 3, is characterized in that, described electrod-array, described microtubular and described optical fiber be arranged in parallel and is combined together to form fascicular texture.
6. parkinson therapy equipment according to claim 1, is characterized in that, described drug-supplying system discharges light sensation gene, the anti-inflammatory factor, neurotrophic factor or angiogenesis factor by microtubular neurad histiocyte.
7. parkinson therapy equipment according to claim 1, is characterized in that, the sharp light wavelength that described light source sends is 472nm or 593nm.
8. parkinson therapy equipment according to claim 1, is characterized in that, described neurotransmitter is at least one in dopamine and glutamic acid.
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| CN201210275424.XA CN102793973B (en) | 2012-08-03 | 2012-08-03 | Device for treating Parkinson's disease |
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| CN103071246B (en) * | 2013-02-19 | 2015-09-09 | 重庆大学 | The neuroactive prosthetic device of near infrared light |
| CN105233413B (en) * | 2015-08-21 | 2018-04-10 | 魏诗荣 | A kind of minimally invasive intervention device of diagnosis and treatment tumour based on conduit |
| FR3045391B1 (en) * | 2015-12-17 | 2019-09-06 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | IMPLANTABLE DEVICE FOR OPTICAL BRAIN STIMULATION |
| CN108744268B (en) * | 2018-03-29 | 2021-10-15 | 北京大学 | Application of flexible transparent carbon nanotube neural electrode array in nerve photoelectric interface |
| CN109171643A (en) * | 2018-06-17 | 2019-01-11 | 南京仁康医院有限公司 | A kind of MX-P neuron resuscitation therapy children's Neurological disease technology |
| CN109199359A (en) * | 2018-10-15 | 2019-01-15 | 暨南大学 | Electrical combined stimulating system and electrical combined stimulation nerve fibre method |
| CN109394202A (en) * | 2018-12-24 | 2019-03-01 | 浙江中医药大学 | Nerve stimulation record component and preparation method thereof |
| CN110231682B (en) * | 2019-05-09 | 2021-07-27 | 上海大学 | Photoelectric optical fiber for regulating and controlling nerve activity and manufacturing method |
| CN111939472A (en) * | 2020-08-10 | 2020-11-17 | 中国科学院上海微系统与信息技术研究所 | Intracranial stimulation recording system and preparation method thereof |
| CN112933406A (en) * | 2021-01-22 | 2021-06-11 | 北京工业大学 | Brain micro device and manufacturing method thereof |
| CN113332582B (en) * | 2021-06-22 | 2023-04-07 | 中山大学 | Drug delivery device, drug delivery system, drug delivery method and application |
| WO2023108489A1 (en) * | 2021-12-15 | 2023-06-22 | 中国科学院深圳先进技术研究院 | Product and method for producing endogenous brain-derived neurotrophic factor |
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| EP2474339A1 (en) * | 2006-12-15 | 2012-07-11 | Nasophlex B.V. | Resuscitation device for resuscitation by stimulating an auricle of a human ear |
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| DE10318071A1 (en) * | 2003-04-17 | 2004-11-25 | Forschungszentrum Jülich GmbH | Device for desynchronizing neuronal brain activity |
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| CN1440256A (en) * | 2000-05-08 | 2003-09-03 | 布雷恩斯盖特有限公司 | Method and apparatus for stimulating sphenopalatine ganglion to modify properties of BBB and cerebral blood flow |
| CN101262904A (en) * | 2005-09-15 | 2008-09-10 | 皇家飞利浦电子股份有限公司 | Apparatus and method for electrostimulation/sensing in vivo |
| EP2474339A1 (en) * | 2006-12-15 | 2012-07-11 | Nasophlex B.V. | Resuscitation device for resuscitation by stimulating an auricle of a human ear |
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