CN105013080A - Closed loop transcranial direct current stimulation device - Google Patents
Closed loop transcranial direct current stimulation device Download PDFInfo
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- CN105013080A CN105013080A CN201510449679.7A CN201510449679A CN105013080A CN 105013080 A CN105013080 A CN 105013080A CN 201510449679 A CN201510449679 A CN 201510449679A CN 105013080 A CN105013080 A CN 105013080A
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Abstract
A closed loop transcranial direct current stimulation device comprises a computer, a signal acquisition and emitting apparatus, a direct current stimulator, a stimulation isolator, a microfilament electrode and a pre-differential amplifier, wherein, the computer and the signal acquisition and emitting apparatus are connected through a data line; the I/O interface of the output terminal of the signal acquisition and emitting apparatus is connected to the signal input terminal of the direct current stimulator; the output terminal of the direct current stimulator is connected to the signal input terminal of the stimulation isolator; the output terminal of the stimulation isolator is connected with the human head through an electrode cap; the input terminal of the microfilament electrode obtains the cranial neural electric signal; the output terminal of the microfilament electrode is connected with the input terminal of a pre-differential amplifier; and the output terminal of the pre-differential amplifier is connected to the A/D interface of the input terminal of the signal acquisition and emitting apparatus. The invention has the advantages of simple structure, convenient control and no damage.
Description
Technical field
The invention belongs to Non-destructive Testing Technique, particularly a kind of closed loop is through cranium galvanic stimulation device.
Background technology
Current, pharmaceutical chemistry treatment nervous system has certain side effect to human body.In order to make up the deficiency of Drug therapy, people make the physiotherapys such as electricity consumption, light, magnetic stimulate cranial nerve.As deep brain stimulation, although stimulation target requires brain implant electrode by force, there is greater risk in operation; Although transcranial magnetic stimulation is accomplished without invading property, there is the degree of depth that stimulates not and the problem of low spatial resolution; Although light sensation gene neuromodulation technology stimulation spatial resolution is high but too complicated in gene technology practical operation.Functional electric stimulation enters clinical stage, and has a lot of product to come out.
At present, the equipment major part being used for the treatment of cerebral nervous system disease in prior art is all open loop equipment, can not the phase place of the spike rhythm and pace of moving things in automatic Prediction EEG signals; Stimulus signal can not be sent in the required moment according to the demand of user.
Summary of the invention
The object of the invention is to provide a kind of manipulation convenience, undamaged closed loop through cranium galvanic stimulation device.
For achieving the above object, have employed following technical scheme: device of the present invention comprises computer, signals collecting and discharger, direct current stimulator, stimulus isolator, fibril electrode, difference preamplifier; Wherein, computer and signals collecting and discharger are connected by data wire, signals collecting is connected with direct current stimulator input with the I/O interface of discharger outfan, the outfan of direct current stimulator is connected with stimulus isolator signal input part, and the outfan of stimulus isolator is connected through electrode cap with human body head; The input of fibril electrode obtains the cranial nerve signal of telecommunication, and the outfan of microelectrode is connected with difference preamplifier input, and the A/D interface of the outfan of difference preamplifier and signals collecting and discharger input is connected.
Described computer is equipped with Labview control software design, is gathered and discharger by software control signals, and the signal frequency range that computer sends is 1Hz ~ 10MHz.
Described signals collecting and discharger are NI USB-6251 digital signal acquiring and transmission cards, and sample frequency is set to 20kHz.
The frequency filtering of described difference preamplifier is 0.3Hz ~ 5KHz, and amplification is 100 times.
Described fibril electrode array is nichrome fibril electrode.
Described direct current stimulator is JL-B electrostimulator.
Described stimulus isolator is JL-E stimulus isolator.
Work process is as follows:
Fibril electrode collects the head nerves signal of telecommunication, after the amplification of difference preamplifier, sampled by the A/D mouth of signals collecting and discharger again, and after computer automatic decision and forecasting process, according to the requirement of user, at the feature locations of the spike rhythm and pace of moving things on the horizon, I/O mouth through signals collecting and discharger provides stimulus signal, through the I/O mouth of signals collecting and discharger, electrostimulator, stimulus isolator, produce the excited head specific region of electrical stimulation signal, inducing neural unit produces action potential, again through fibril electrode acquired signal, and so forth, form a closed-loop control system.Closed loop nerve stimulation or brain regulation and control are carried out to experimental subject.
The present invention compared with prior art tool has the following advantages:
1, galvanic stimulation acts on scalp through electrode cap, can stimulate nerve with no damage.
2, use closed-loop control systems, the phase place of the spike rhythm and pace of moving things in energy automatic Prediction EEG signals, detects epileptic spike.
3, according to the setting of user, stimulus signal can be sent in the required moment, for the further investigation of cerebral nervous system working mechanism and mechanism of action provides useful instrument.
Accompanying drawing explanation
Fig. 1 is structured flowchart of the present invention.
Fig. 2 is use FB(flow block) of the present invention.
Detailed description of the invention
At the closed loop shown in Fig. 1 in the structured flowchart of cranium galvanic stimulation device, computer and signals collecting and discharger are connected by data wire, signals collecting is connected with the signal input part of electrostimulator with the I/O interface of discharger outfan, the outfan of electrostimulator is connected with the signal input part of stimulus isolator, and the outfan of stimulus isolator is connected by electrode cap with human body head; The input of fibril electrode obtains the cranial nerve signal of telecommunication, and the outfan of fibril electrode is connected with difference preamplifier input, and the A/D interface of the outfan of difference preamplifier and signals collecting and discharger input is connected.
Described computer is equipped with Labview control software design, is gathered and discharger by software control signals, and the signal frequency range that computer sends is 1Hz ~ 10MHz.
Described signals collecting and discharger are NI USB-6251 digital signal acquiring and transmission cards, and sample frequency is set to 20kHz.
The frequency filtering of described difference preamplifier is 0.3Hz ~ 5KHz, and amplification is 100 times.
Described fibril electrode array is nichrome fibril electrode.
Described direct current stimulator is JL-B electrostimulator.
Described stimulus isolator is JL-E stimulus isolator.
The using method of this device, as shown in Figure 2, comprises following operating procedure:
(1) electrode slice (Neurosky, USA) is pasted on the scalp of human body;
(2) stimulus signal that the computer that Labview control software design is housed sends is through signals collecting and discharger (NI USB-6251, and direct current stimulator (JL-B USA), Shanghai Jia Longjiao instrument factory) produce electrical stimulation signal afterwards, electrical stimulation signal is again through stimulus isolator (JL-E, Shanghai Jia Longjiao instrument factory) after, pass to electrode slice;
(3) electrical stimulation signal that electrostimulator produces arrives human body head through stimulus isolator and electrode cap, acts on, cause nervous physiology to change with head nerves;
(4) fibril electrode (Blackrock Microsystems, USA) the head nerves signal of telecommunication collected, pass to difference preamplifier (1800 types, A & M, USA), difference preamplifier and then electroneurographic signal amplified, and is transferred to signals collecting and discharger;
(5) the A/D mouth of signals collecting and discharger is sampled to electroneurographic signal, passes to the computer with control software design, and computer carries out interpretation and application to the electroneurographic signal gathered;
(6) computer is to after electroneurographic signal prediction, according to the requirement of user, sends stimulus signal at the feature locations of the spike rhythm and pace of moving things on the horizon;
(7) stimulus signal that sends of computer, through the I/O mouth of signals collecting and discharger, be delivered to direct current stimulator, direct current stimulator sends pulse signal;
(8) the excited head specific region of stimulus signal energy of electrostimulator generation, thus inducing neural unit produces action potential.
Above-described embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various distortion that those of ordinary skill in the art make technical scheme of the present invention, improvement, modification, substitute, combination, to simplify, all should fall in protection domain that claims of the present invention determines.
Claims (5)
1. closed loop is through a device for cranium galvanic stimulation, it is characterized in that: described device comprises computer, signals collecting and discharger, direct current stimulator, stimulus isolator, fibril electrode, difference preamplifier; Wherein, computer is connected by data wire with discharger with signals collecting, signals collecting is connected with the signal input part of direct current stimulator with the I/O interface of discharger outfan, the outfan of direct current stimulator is connected with the signal input part of stimulus isolator, and the outfan of stimulus isolator is connected through electrode cap with human body head; The input of fibril electrode obtains the cranial nerve signal of telecommunication, and the outfan of fibril electrode is connected with difference preamplifier input, and the A/D interface of the outfan of difference preamplifier and signals collecting and discharger input is connected.
2. a kind of closed loop according to claim 1 is through the device of cranium galvanic stimulation, it is characterized in that: described computer is equipped with Labview control software design, gathered and discharger by software control signals, the signal frequency range that computer sends is 1Hz ~ 10MHz.
3. a kind of closed loop according to claim 1 is through the device of cranium galvanic stimulation, it is characterized in that: described signals collecting and discharger are NI USB-6251 digital signal acquiring and transmission cards, and sample frequency is set to 20kHz.
4. a kind of closed loop according to claim 1 is through the device of cranium galvanic stimulation, it is characterized in that: the frequency filtering of described difference preamplifier is 0.3Hz ~ 5KHz, and amplification is 100 times.
5. a kind of closed loop according to claim 1 is through the device of cranium galvanic stimulation, it is characterized in that: described fibril electrode is nichrome electrode.
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| CN201510449679.7A CN105013080A (en) | 2015-07-28 | 2015-07-28 | Closed loop transcranial direct current stimulation device |
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| CN201510449679.7A CN105013080A (en) | 2015-07-28 | 2015-07-28 | Closed loop transcranial direct current stimulation device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105486888A (en) * | 2015-11-30 | 2016-04-13 | 燕山大学 | Transcranial direct current stimulation and laser Doppler velocity measurement integrated device |
| CN109875553A (en) * | 2019-03-27 | 2019-06-14 | 北京脑陆科技有限公司 | A kind of extensive epilepsy automatic detection early warning based on EEG equipment and treatment intelligence system |
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| CN102698360A (en) * | 2012-04-21 | 2012-10-03 | 南京理工大学 | High-focusing-capability multi-channel transcranial direct current stimulation device and control method thereof |
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| US20150105837A1 (en) * | 2013-10-16 | 2015-04-16 | Neurometrics, S.L. | Brain therapy system and method using noninvasive brain stimulation |
| CN204411500U (en) * | 2014-12-23 | 2015-06-24 | 先進電子醫療工業有限公司 | Wear-type controlled in wireless electrical transcranial stimulation instrument |
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Patent Citations (6)
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| US20080319505A1 (en) * | 2007-05-09 | 2008-12-25 | Massachusetts Institute Of Technology | Integrated Transcranial Current Stimulation and Electroencephalography Device |
| CN102783948A (en) * | 2011-05-20 | 2012-11-21 | 索尼公司 | Electroencephalogram activation apparatus |
| US20130079659A1 (en) * | 2011-09-23 | 2013-03-28 | Elshan Akhadov | INTEGRATION OF ELECTROENCEPHALOGRAPHY (EEG) AND TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) WITH HIGH-SPEED OPERATION, ELECTRODE, RE-USE, AUTOMATED tDCS ELECTRODE CONFIGURATION, AND MULTIPLE INDEPENDENT tDCS CURENT SOURCES |
| CN102698360A (en) * | 2012-04-21 | 2012-10-03 | 南京理工大学 | High-focusing-capability multi-channel transcranial direct current stimulation device and control method thereof |
| US20150105837A1 (en) * | 2013-10-16 | 2015-04-16 | Neurometrics, S.L. | Brain therapy system and method using noninvasive brain stimulation |
| CN204411500U (en) * | 2014-12-23 | 2015-06-24 | 先進電子醫療工業有限公司 | Wear-type controlled in wireless electrical transcranial stimulation instrument |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105486888A (en) * | 2015-11-30 | 2016-04-13 | 燕山大学 | Transcranial direct current stimulation and laser Doppler velocity measurement integrated device |
| CN109875553A (en) * | 2019-03-27 | 2019-06-14 | 北京脑陆科技有限公司 | A kind of extensive epilepsy automatic detection early warning based on EEG equipment and treatment intelligence system |
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Application publication date: 20151104 |