CN102039007A - Therapy equipment with targeting function - Google Patents

Abstract

A therapeutic device with a targeting function, comprising a central control module, an optical stimulation module, an optical fiber, a signal acquisition module and a sustained release module, the central control module controls the optical stimulation module, the signal acquisition module and the sustained release module; The slow-release module is used to release targeted photosensitive materials and/or photosensitive genes; the photo-stimulation module generates laser light and performs photostimulation to the targeted photosensitive materials and/or photosensitive genes through the optical fiber; The signal collection module is used to collect biological signals in the lesion area before and after light stimulation, and send them to the central control module, and the central control module generates corresponding parameters for the analysis and processing of the biological signals, according to the parameters respectively Controlling the light stimulation module and the sustained release module. The above-mentioned therapeutic device with targeting function can reduce the damage to the normal tissue of the patient and improve the therapeutic effect because the targeted light-sensitive material can accurately enter the tumor cells and be excited without entering the normal cells.

Description

Therapeutic Devices with Targeting Function

【Technical field】

The invention relates to the field of medical devices, in particular to a treatment device with a targeting function.

【Background technique】

Tumors that grow in the brain are collectively called brain tumors, including primary brain tumors that originate from the brain parenchyma and secondary brain tumors that metastasize to the brain from other parts of the body. In recent years, the incidence of brain tumors is on the rise, and 20-30% of other malignant tumors will eventually transfer to the brain. Once a brain tumor occupies a certain space in the brain, no matter whether its nature is benign or malignant, it will increase intracranial pressure, compress brain tissue, damage the central nervous system, and endanger the life of the patient.

Traditionally, there are three main treatments for central nervous system tumors: surgery, chemotherapy and radiation therapy. Among them, surgical treatment is to resect the tumor through surgery to remove tumor cells and prevent their differentiation and growth. However, the trauma of the surgical process is relatively large, and it is easy to cause unpredictable or irreversible results, leaving serious sequelae for patients; Chemotherapy is a treatment method that uses chemical drugs to kill tumor cells and inhibit the growth and reproduction of tumor cells. It has therapeutic effects on primary tumors and metastases, but it will kill tumor cells and normal cells at the same time, causing serious harm to patients. Injury; Radiation therapy refers to killing tumor cells with radiation, which is effective for many tumors, but it can also cause harm to patients.

With the advancement of treatment methods, some new treatment methods have appeared in recent years, such as electrochemical therapy and so on. Electrochemical therapy (ECT) is a method of treating tumors with local electrical pulse stimulation. It produces a series of electrochemical reactions in the tumor through direct current and current pulses, causing changes in the living environment of tumor cells, and at the same time forcing changes in the conformation of DNA, enzymes and proteins, eventually leading to the death of tumor cells. This method is highly destructive to in vivo or superficial tumors, and the extent of damage is easy to control. It can selectively kill tumor cells, but it may cause fever or skin reactions, and severe local burns or necrosis may result in patients.

To sum up, the traditional methods of treating tumors are likely to cause greater damage to patients and bring adverse effects to patients.

【Content of invention】

Based on this, it is necessary to provide a therapeutic device with a specific targeting function, which can reduce the damage to the normal tissue of the patient and improve the therapeutic effect.

A therapeutic device with a targeting function, comprising a central control module, an optical stimulation module, an optical fiber, a signal acquisition module and a sustained release module, the central control module controls the optical stimulation module, the signal acquisition module and the sustained release module; The sustained-release module is used to release the targeted photosensitive material and/or photosensitive gene; the photostimulation module generates laser light and performs photostimulation to the targeted photosensitive material and/or photosensitive gene through the optical fiber; The signal collection module is used to collect biological signals in the lesion area before and after light stimulation, and send them to the central control module. The central control module analyzes and processes the biological signals to generate corresponding parameters, and respectively Controlling the light stimulation module and the sustained release module.

Preferably, the light stimulation module includes a first light source device, a second light source device and a third light source device, the first light source device excites the targeted photosensitive material through the optical fiber, the second light source device and the third light source device The third light source excites the light-sensitive gene through the optical fiber.

Preferably, the first light source device generates ultraviolet light with a wavelength range of 300-400 nanometers.

Preferably, the second light source generates blue light with a wavelength of 473 nm, and the third light source generates yellow light with a wavelength of 594 nm.

Preferably, the targeting photosensitive material includes one or both of an active targeting photosensitive material and a passive targeting photosensitive material.

Preferably, the active targeting photosensitive material includes a surface-modified, antibody-mediated or receptor-mediated photosensitive preparation.

Preferably, the passive targeting photosensitive material includes one or more of nano-titanium dioxide, nano-zinc oxide, carbon nanotubes, graphene, fullerene, and organic optoelectronic materials.

Preferably, the size of the passive targeting photosensitive material is less than 100 nanometers.

Preferably, the slow-release module is also used to release one or both of neurotrophic factors and angiogenesis factors.

Preferably, the signal acquisition module includes one or more of an electrical signal acquisition unit, an optical signal acquisition unit, a chemical sensor, and a biosensor.

Preferably, the biological signal includes one or more of electrophysiological signal, optical signal, temperature, pH value, blood sugar concentration, oxygen concentration and ion concentration.

Preferably, the therapeutic device with targeting function further includes an electrical stimulation device and electrodes, the central control module controls the electrical stimulation device, and the electrical stimulation device performs electrical stimulation through the electrodes.

Preferably, the therapeutic device with targeting function further includes a power supply module, which is used to provide electrical energy for the central control module, light stimulation module, signal collection module and sustained release module.

Preferably, the power supply module is one or more of a primary battery, a secondary battery and a radio frequency power supply module.

The above-mentioned treatment device with targeting function uses a slow-release module to release targeted photosensitive materials into tumor cells, and the photostimulation module generates laser light to excite the targeted photosensitive materials to kill tumor cells, because the targeted photosensitive materials can accurately enter the tumor Cells, without entering normal cells, when the laser is used to excite the targeted photosensitive material, it can reduce the damage to the normal tissue of the patient and improve the therapeutic effect.

【Description of drawings】

Fig. 1 is a structural schematic diagram of a therapeutic device with targeting function in an embodiment;

Fig. 2 is a schematic structural diagram of a therapeutic device with targeting function in another embodiment.

【Detailed ways】

A detailed description will be given below in conjunction with specific embodiments.

As shown in FIG. 1 , in one embodiment, a therapeutic device with targeting function includes a central control module 10 , a sustained release module 20 , a signal collection module 30 , an optical stimulation module 40 and an optical fiber 50 . in,

The central control module 10 controls the sustained release module 20 , the signal acquisition module 30 and the light stimulation module 40 to work.

The sustained release module 20 is used for releasing targeted photosensitive materials and/or photosensitive genes. Targeted light-sensitive materials are used to selectively enter tumor cells, and are excited under laser irradiation to kill tumor cells; light-sensitive genes are used to be excited under laser irradiation to regulate target cells, inhibit tumor growth and help neurons The role of functional reconstruction. Targeted photosensitive materials include one or both of active targeted photosensitive materials and passive targeted photosensitive materials, wherein active targeted photosensitive materials include chemically or biologically modified photosensitive preparations; passive targeted photosensitive materials It includes one or more of nano-titanium dioxide, nano-zinc oxide, carbon nanotubes, graphene, fullerene, and organic photoelectric materials, and the size of the passively targeted photosensitive material is less than 100 nanometers. Because the permeability of capillaries in tumor tissue is greater than that in normal tissues, nanoparticles below 100 nanometers are more likely to penetrate into tumor tissues through the capillary walls of the lesion, while the permeability of capillaries in normal tissues is very small, which is not allowed. These particles pass through, so that the material with a size smaller than 100 nanometers will passively diffuse into the tumor cells to achieve more accurate localization.

In addition, the slow-release module 20 is also used to release one or both of neurotrophic factors and angiogenesis factors. Neurotrophic factors and vascular growth factors are used to promote the regeneration of nerves and blood vessels at the lesion site.

The signal collection module 30 is used to collect biological signals in the lesion area before and after light stimulation, and send the biological signals to the central control module 10 . The signal acquisition module 30 includes one or more of an electrical signal acquisition unit, an optical signal acquisition unit, a chemical sensor, and a biosensor. Biological signals include one or more of electrophysiological signals, optical signals, temperature, pH value, blood sugar concentration, oxygen concentration, and ion concentration. The electrical signal acquisition unit is used to collect electrophysiological signals, the optical signal acquisition unit is used to collect optical signals, the chemical sensor can be used to collect pH value, temperature, ion concentration and other signals, and the biosensor can be used to collect blood sugar concentration, oxygen concentration, etc. The growth status of the tumor can be analyzed by collecting biological signals. Among them, the electrophysiological signal is used to analyze the neural activity of the lesion; the optical signal is used to observe the activity of the target cell of the introduced light-sensitive gene; the temperature can determine the position and size of the tumor, because the temperature of the tumor tissue is generally higher than Normal tissue should be higher; pH value can reflect the growth of tumor tissue, because the pH value of tumor cell interstitial fluid is significantly lower than that of surrounding normal tissue; blood glucose concentration or oxygen concentration can indirectly reflect the activity of tumor tissue, because tumor cell metabolism Exuberant, rapid diffusion, long-term hypoxic state; specific ion concentration can reflect the growth of tumor tissue, because the rapid growth of tumor blood vessels usually leads to the lack of adventitial cells, deformation of the basement membrane, and defects in the lymphatic return system.

The signal collection module 30 sends the collected biological signal to the central control module 10, and the central control module 10 can analyze and process the biological signal to generate corresponding parameters, and then control the slow-release module 10 and the light stimulation module 40 respectively according to the parameters. Among them, the parameters include stimulation frequency (unit: Hz), intensity (unit: volt or ampere), duration (unit: second), interval (unit: second), flow rate (unit: milliliter per second, mL/s), etc. . The central control module 10 can also feed back the information of the biological signal to the connected computer, and output the information of the biological signal in form, image or sound, so that doctors or patients can know it in time.

The light stimulation module 40 includes a first light source, a second light source and a third light source. The first light source device is used to generate laser light and excite targeted photosensitive materials through the optical fiber 50 , and the second light source device and the third light source device are used to generate laser light and excite photosensitive genes through the optical fiber 50 . Wherein, the first light source device generates ultraviolet light with a wavelength range of 300-400 nanometers (nm); the second light source device generates blue light with a wavelength of 473 nm; and the third light source device generates yellow light with a wavelength of 594 nm. The laser light generated by the optical stimulation module 40 goes deep into the target tissue through the optical fiber 50 for irradiation, and the laser light generated by the first light source excites the targeted photosensitive material to make it work and kill tumor cells, while other normal tissues will not be affected. Due to the specificity of the combination of targeted photosensitive materials and target cells, passive targeted photosensitive materials will continue to diffuse into other tumor cells after tumor cells are killed, so a small dose can meet the treatment requirements.

After the tumor cells are killed, the light-sensitive gene can be transferred into and expressed in neurons through a specific promoter. Blue (wavelength: 472 nm) or yellow (wavelength: 593 nm) laser light is emitted by the second laser and irradiated into the target tissue by the optical fiber 50 . Since the blue or yellow laser only acts on cells into which light-sensitive genes have been introduced, it has very strong cell specificity and can effectively excite or inhibit neurons. Wherein, the excitatory channel protein gene is ChR2 (Channelrhodopsin-2), and the inhibitory channel protein gene is NpHR (Helorhodopsin). The optical stimulation module 40 provides optical stimulation to the neurons with light-sensitive genes in the brain through the optical fiber 50 buried in the brain, thereby causing the excitation or inhibition of the neurons, that is, stimulating the neurons expressing the excitatory channel protein gene with blue light , will excite this type of neuron; while stimulating neurons expressing the inhibitory channel protein gene with yellow light will inhibit this type of neuron. Neural circuits can be regulated through excitation or inhibition, so as to achieve the purpose of treating damaged nerve tissue and reshaping nerve function.

In one embodiment, as shown in FIG. 2 , the above-mentioned therapeutic device with targeting function includes not only a central control module 10, a sustained release module 20, a signal acquisition module 30, an optical stimulation module 40 and an optical fiber 50, but also an electrical Stimulation module 60, electrode 70 and power supply module (not shown in the figure). The central control module 10 controls the electrical stimulation module 60 to perform electrical stimulation through the electrodes 70 . The electrical stimulation module 60 uses brain stereotactic surgery to implant electrodes 70 in a special position in the brain, and stimulates the deep brain nuclei by generating current or potential pulses. The central control module 10 can adjust the current intensity and potential pulse frequency. to achieve the effect of killing tumor cells. The electrical stimulation therapy generated by the electrical stimulation module 60 can be used as a supplement to the light stimulation therapy. Alternatively, the electrode 70 and the optical fiber 50 may be integrated together.

The power supply module provides electrical energy for the central control module 10 , the sustained release module 20 , the signal acquisition module 30 , the light stimulation module 40 , the electrical stimulation module 60 and the electrodes 70 . The power supply module 80 can be one or more of a primary battery, a secondary battery and a radio frequency power supply module. Among them, the primary battery can be a lithium battery, a silver oxide battery or a biofuel cell (such as providing electric energy by enzymatically catalyzing its own glucose); the secondary battery can be a lithium ion battery or a lithium polymer battery. The radio frequency power supply module generates electric energy through the induction of the coil implanted in the living body. For a more stable and durable power supply, both the radio frequency power supply module and the biofuel cell can be used together with the secondary battery to charge it.

The working process of the above-mentioned therapeutic device with targeting function is: the central control module 10 controls the slow-release module 20 to release targeted photosensitive materials and photosensitive genes, and the first laser of the photostimulation module 40 generates 300-400 nanometers of ultraviolet light to excite the target. The light-sensitive material is used to make it work in the tumor cells and kill the tumor cells. The signal acquisition module 20 collects biological signals and sends them to the central control module 10. The central control module 10 analyzes and processes the collected biological signals to generate corresponding parameters. , and then adjust the photostimulation module 40 through this parameter to further kill tumor cells, the second laser and the third laser of the photostimulation module 40 respectively generate blue light and yellow light to stimulate the expression of photosensitive genes in target cells, thereby achieving the treatment of nerve tissue, The purpose of remodeling neurological function.

The above therapeutic device with targeting function uses the sustained release module 20 to release the targeted photosensitive material into the tumor cells, and the photostimulation module 40 generates laser light to excite the targeted photosensitive material to kill tumor cells, because the targeted photosensitive material can accurately Into tumor cells, but not into normal cells, when the laser is used to excite the targeted photosensitive material, it can reduce the damage to the normal tissue of the patient and improve the therapeutic effect.

In addition, the slow-release module 20 is used to release the light-sensitive gene to the nerve tissue, and the light-stimulating module 40 generates laser light to stimulate the expression of the light-sensitive gene, which repairs the nerve tissue and further reduces the damage to normal tissue; the slow-release module 20 can also Release neurotrophic factors to promote the growth and activity of nerves, or release vascular growth factors to enhance microcirculation in the lesion area, promote the repair of lesion tissue, and thus further promote the repair of normal tissue; the use of passive targeting light-sensitive materials can be recycled, The adverse effect of the medicine on the human body is reduced and the treatment cost is saved; the electric stimulation treatment is realized by using the electric stimulation module 60 and the electrode 70 as an auxiliary means of the light stimulation treatment, and the treatment effect is improved.

The above-mentioned embodiments only express several implementation modes of the present invention, and the description thereof is relatively specific and detailed, but should not be construed as limiting the patent scope of the present invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (14)

1. A therapeutic device having a targeting function, characterized in that: the device comprises a central control module, a light stimulation module, an optical fiber, a signal acquisition module and a slow release module, wherein the central control module controls the light stimulation module, the signal acquisition module and the slow release module; the slow release module is used for releasing the targeted light sensitive material and/or the light sensitive gene; the optical stimulation module generates laser and performs optical stimulation on the targeted photosensitive material and/or photosensitive gene through the optical fiber; the signal acquisition module is used for acquiring biological signals in a focus area before and after light stimulation and sending the biological signals to the central control module, the central control module analyzes and processes the biological signals to generate corresponding parameters, and the light stimulation module and the slow release module are respectively controlled according to the parameters.

2. The treatment device with targeting function according to claim 1, characterized in that: the light stimulation module comprises a first light source device, a second light source device and a third light source device, the first light source device excites the targeted light sensation material through the optical fibers, and the second light source device and the third light source device excite the light sensitivity genes through the optical fibers.

3. The treatment device with targeting function according to claim 2, characterized in that: the first light source generates ultraviolet light with the wavelength range of 300-400 nanometers.

4. The treatment device with targeting function according to claim 2, characterized in that: the second light source generates blue light having a wavelength of 473 nm and the third light source generates yellow light having a wavelength of 594 nm.

5. The treatment device with targeting function according to claim 1, characterized in that: the targeted light sensation material comprises one or two of an active targeted light sensation material and a passive targeted light sensation material.

6. The treatment device with targeting function according to claim 5, characterized in that: the active targeting photosensitive material comprises a photosensitive preparation subjected to surface modification, antibody mediation or receptor mediation.

7. The treatment device with targeting function according to claim 5, characterized in that: the passive targeting light sensation material comprises one or more than two of nano titanium dioxide, nano zinc oxide, a carbon nano tube, graphene, fullerene and an organic photoelectric material.

8. The treatment device with targeting function according to claim 5, characterized in that: the size of the passive targeted light sensation material is less than 100 nanometers.

9. The treatment device with targeting function according to claim 1, characterized in that: the slow release module is also used for releasing one or two of neurotrophic factors and blood vessel growth factors.

10. The treatment device with targeting function according to claim 1, characterized in that: the signal acquisition module comprises one or more than two of an electric signal acquisition unit, an optical signal acquisition unit, a chemical sensor and a biological sensor.

11. The treatment device with targeting function according to claim 1, characterized in that: the biological signal comprises one or more than two of electrophysiological signal, optical signal, temperature, pH value, blood glucose concentration, oxygen concentration and ion concentration.

12. The treatment device with targeting function according to claim 1, characterized in that: the treatment device with the targeting function further comprises an electrical stimulation device and an electrode, the central control module controls the electrical stimulation device, and the electrical stimulation device carries out electrical stimulation through the electrode.

13. The treatment device with targeting function according to claim 1, characterized in that: the treatment device with the targeting function further comprises a power supply module, and the power supply module is used for providing electric energy for the central control module, the light stimulation module, the signal acquisition module and the slow release module.

14. The targeted therapeutic device of claim 13, wherein: the power supply module is one or more than two of a primary battery, a secondary battery and a radio frequency power supply module.

Images