CN102039007A - Therapy equipment with targeting function - Google Patents

Therapy equipment with targeting function Download PDF

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Publication number
CN102039007A
CN102039007A CN 201010557946 CN201010557946A CN102039007A CN 102039007 A CN102039007 A CN 102039007A CN 201010557946 CN201010557946 CN 201010557946 CN 201010557946 A CN201010557946 A CN 201010557946A CN 102039007 A CN102039007 A CN 102039007A
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module
therapy equipment
photostimulation
target function
function according
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CN 201010557946
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Chinese (zh)
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鲁艺
王立平
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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Priority to CN 201010557946 priority Critical patent/CN102039007A/en
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Abstract

The invention relates to therapy equipment with a targeting function, comprising a central control module, a photostimulation module, optical fiber, a signal acquisition module and a slow release module, wherein the central control module controls the photostimulation module, the signal acquisition module and the slow release module; the slow release module is used for releasing a targeted photosensitive material and/or photosensitive gene; the photostimulation module generates laser and carries out photostimulation on the targeted photosensitive material and/or photosensitive gene by the optical fiber; the signal acquisition module is used for acquiring biological signals in a focus before and after photostimulation and transmitting the biological signals to the central control module; and the central control module analyzes and processes the biological signals to generate corresponding parameters and respectively controls the photostimulation module and the slow release module according to the parameters. Since the targeting photosensitive material can enter tumor cells to be excited, but not enter normal cells, the therapy equipment with the targeting function can reduce the damages to normal tissues of a patient and improves the therapy effect.

Description

Therapy equipment with target function
[technical field]
The present invention relates to medical instruments field, particularly a kind of therapy equipment with target function.
[background technology]
The tumor that grows in intracranial is commonly referred to as cerebroma, comprises the primary brain tumor that is taken place by brain essence and is transferred to the Secondary cases cerebroma of intracranial by other positions of health.In recent years, the cerebroma sickness rate is in rising trend, and other malignant tumor has 20～30% finally can change intracranial over to.Cerebroma no matter its character is optimum or pernicious, all can make intracranial pressure raise after in a single day intracranial occupies certain space, the compressing cerebral tissue, and the infringement nervus centralis jeopardizes patient's life.
Traditional treatment for central nerve tumor is mainly three kinds of operative treatment, chemotherapy and radiation cures.Wherein, operative treatment be exactly by surgical operation with tumor resection, reach the removing tumor cell, stop the purpose of its differential growth, but the wound of operation process is bigger, easily cause unpredictable or irreversible result, stay serious sequela to the patient; Chemotherapy is a kind of therapeutic modality that utilizes chemicals kill tumor cell, suppresses the growth and breeding of tumor cell, and it all has therapeutical effect to primary tumor, metastasis etc., but meeting while killing tumor cell and normal cell damage to the patient; Radiotherapy is meant with ray kills tumor cell, better to the effect of many tumors, but also can damage to the patient.
Along with the progress of Therapeutic Method, some new Therapeutic Method had appearred in the last few years, as electrochemotherapy etc. again.(Electrochemical therapy ECT) is a kind of method of utilizing local electric pulse stimulation treatment tumor to electrochemotherapy.It makes tumor by local produce a series of electrochemical reactions by unidirectional current and current impulse, causes the living environment of tumor cell to change, and forces DNA, enzyme and protein conformation to change simultaneously, finally causes the death of tumor cell.This method is in the body or to show shallow tumor destruction strong, and damage envelope is easy to control, can the selective killing tumor cell, but may cause heating or dermoreaction, serious meeting causes patient's topical burn or necrosis.
In sum, the damage that the method for traditional treatment tumor is all bigger to patient Yi Zaocheng brings harmful effect to the patient.
[summary of the invention]
Based on this, be necessary to provide a kind of therapy equipment of concrete target function, can reduce destruction to patient's normal structure, improve therapeutic effect.
A kind of therapy equipment with target function comprises central control module, photostimulation module, optical fiber, signal acquisition module and slow release module, and described central control module is controlled described photostimulation module, signal acquisition module and slow release module; Described slow release module is used to discharge targeting photoactive material and/or photaesthesia gene; Described photostimulation module produces laser and by described optical fiber described targeting photoactive material and/or photaesthesia gene is carried out photostimulation; Described signal acquisition module is used to gather the bio signal through in the focal zone before and after the photostimulation, and send to described central control module, described central control module generates relevant parameters to described bio signal analyzing and processing, controls described photostimulation module and slow release module respectively according to described parameter.
Preferably, described photostimulation module comprises the first light source device, secondary light source device and the 3rd light source device, the described first light source device excites described targeting photoactive material by described optical fiber, and described secondary light source device and the 3rd light source device excite described photaesthesia gene by described optical fiber.
Preferably, described first light source device generation wave-length coverage is the ultraviolet light of 300～400 nanometers.
Preferably, it is the blue light of 473 nanometers that described secondary light source produces wavelength, and it is the gold-tinted of 594 nanometers that described the 3rd light source produces wavelength.
Preferably, described targeting photoactive material comprises one or both in active targeting photoactive material and the passive target photoactive material.
Preferably, described active targeting photoactive material comprises through finishing, antibody-mediated or receptor-mediated photosensitive agents.
Preferably, described passive target photoactive material comprises one or more in nano titanium oxide, nano zine oxide, CNT, Graphene, fullerene, the organic photoelectrical material.
Preferably, the size of described passive target photoactive material is less than 100 nanometers.
Preferably, described slow release module also is used for discharging one or both of neurotrophic factor, angiogenesis factor.
Preferably, described signal acquisition module comprises one or more in electrical signal collection unit, light signal collection unit, chemical sensor, the biosensor.
Preferably, described bio signal comprises one or more in electricity physiological signal, optical signal, temperature, pH value, blood sugar concentration, oxygen concentration, the ion concentration.
Preferably, described therapy equipment with target function also comprises electrical stimulation device and electrode, and described central control module is controlled described electrical stimulation device, and described electrical stimulation device carries out electricity irritation by described electrode.
Preferably, described therapy equipment with target function also comprises power module, and described power module is used to described central control module, photostimulation module, signal acquisition module and slow release module that electric energy is provided.
Preferably, described power module is one or more in one-shot battery, secondary cell and the radio frequency powered module.
Above-mentioned therapy equipment with target function, adopt the slow release module to discharge the targeting photoactive material in tumor cell, the photostimulation module produces laser excitation targeting photoactive material, killing tumor cell, because of the targeting photoactive material can accurately enter tumor cell, and do not enter normal cell, when adopting laser excitation targeting photoactive material, can reduce destruction, improve therapeutic effect patient's normal structure.
[description of drawings]
Fig. 1 is the structural representation that has the therapy equipment of target function among the embodiment;
Fig. 2 is for having the structural representation of the therapy equipment of target function among another embodiment.
[specific embodiment]
Be described in detail below in conjunction with specific embodiment.
As shown in Figure 1, in one embodiment, a kind of therapy equipment with target function comprises central control module 10, slow release module 20, signal acquisition module 30, photostimulation module 40 and optical fiber 50.Wherein,
Central control module 10 controlling slow release modules 20, signal acquisition module 30 and 40 work of photostimulation module.
Slow release module 20 is used to discharge targeting photoactive material and/or photaesthesia gene.The targeting photoactive material is used for selecting to enter tumor cell, and is excited the kill tumor cell under the irradiation of laser; The photaesthesia gene is used for being excited under laser irradiation, and the goal of regulation and control cell plays the effect that suppresses tumor growth and help function of nervous system to rebuild.The targeting photoactive material comprises one or both in active targeting photoactive material and the passive target photoactive material, and wherein active targeting photoactive material comprises the photosensitive agents through chemistry or bio-modification; The passive target photoactive material comprises one or more in nano titanium oxide, nano zine oxide, CNT, Graphene, fullerene, the organic photoelectrical material, and the size of passive target photoactive material is less than 100 nanometers.Because of the permeability of the blood capillary of tumor tissues bigger than normal structure, the following nano-particle of 100 nanometers easily infiltrates in the tumor tissues by the capillary wall of lesions position, and the capillary permeability of normal structure is very little, do not allow these granules to pass through, so size realizes accurate in locating more less than passive being diffused in the tumor cell of 100 nano materials meeting.
In addition, slow release module 20 also is used for discharging one or both medicines of neurotrophic factor, angiogenesis factor.Neurotrophic factor, angiogenesis factor are used to promote the nerve and the revascularization of lesions position.
Signal acquisition module 30 is used to gather the bio signal through in the focal zone before and after the photostimulation, and this bio signal is sent to central control module 10.Signal acquisition module 30 comprises one or more in electrical signal collection unit, light signal collection unit, chemical sensor, the biosensor.Bio signal comprises one or more in electricity physiological signal, optical signal, temperature, pH value, blood sugar concentration, oxygen concentration, the ion concentration.The electrical signal collection unit is used to adopt electricity physiological signal, light signal collection unit to be used to gather optical signal, and chemical sensor can be used for gathering signals such as pH value, temperature, ion concentration, and biosensor can be used for gathering blood sugar concentration, oxygen concentration etc.Can analyze the growth of tumor situation by gathering bio signal.Wherein, electricity physiological signal is used to analyze the neural activity situation of lesions position; Optical signal is used to observe the active situation of target cell of the photaesthesia gene of importing; Temperature can be determined information such as the position of tumor and size, because of the temperature of tumor tissues generally than normal structure height; PH value can reflect the growing state of tumor tissues, because of the pH value of tumor cell interstitial fluid remarkable lower than normal surrounding tissue; Blood sugar concentration or oxygen concentration can reflect the activity of tumor tissues indirectly, and be vigorous because of the tumor cell metabolism, diffusion velocity is fast, is in hypoxia for a long time; Particular ion concentration can reflect the growing state of tumor tissues, because of tumor vascular growth is rapid, causes adventitial cell to lack usually, the basement membrane distortion, and lymph pipeline return-flow system is damaged.
Signal acquisition module 30 sends to central control module 10 with the bio signal of gathering, and central control module 10 can generate relevant parameters to this bio signal analyzing and processing, again according to this parameter difference controlling slow release module 10 and photostimulation module 40.Wherein, parameter comprise the frequency (unit: hertz), intensity (unit: volt or ampere), time-histories (unit: second) of stimulation, at interval (unit: second), flow velocity (unit: the milliliter per second, mL/s) etc.Central control module 10 can also be exported the information of this bio signal with the information feedback of this bio signal to the computer that connects in the mode of form, image or sound, be convenient to the doctor or the patient in time understands.
Photostimulation module 40 comprises the first light source device, secondary light source device and the 3rd light source device.The first light source device is used to produce laser and excites the targeting photoactive material by optical fiber 50, and secondary light source device and the 3rd light source device are used to produce laser and pass through optical fiber 50 exciting light sensitive genes.Wherein, first light source device generation wave-length coverage is the ultraviolet light of 300～400 nanometers (nm); It is the blue light of 473 nanometers that the secondary light source device produces wavelength; It is the gold-tinted of 594 nanometers that the 3rd light source device produces wavelength.The laser that photostimulation module 40 produces is deep in the destination organization by optical fiber 50 and shines, the laser excitation targeting photoactive material that the first light source device produces, it is had an effect, killing tumor cell, other normal structures can not be affected, and because of targeting photoactive material and the bonded particularity of target cell, the passive target photoactive material is after tumor cell is killed and wounded, can continue to be diffused in other tumor cells, so smaller dose just can reach the requirement of treatment.
After tumor cell is killed and wounded, can be transferred to neuron in and expression by special promoter the photaesthesia gene.Send yellow (wavelength the is 593nm) laser that blueness (wavelength is 472nm) or the 3rd laser instrument send by second laser instrument, and shine in the destination organization by optical fiber 50.Because blueness or yellow laser only work to the cell that has imported the photaesthesia gene, therefore have very strong cell-specific, and can effectively excited or inhibition neuron.Wherein, the excited type channel protein gene is ChR2 (Channelrhodopsin-2), and inhibition type channel protein gene is NpHR (Helorhodopsin).Photostimulation module 40 has the neuron of photaesthesia gene that photostimulation is provided in brain by the optical fiber 50 that buries in the brain, cause neuronic excitement or inhibition thus, promptly stimulate and express the neuron that the excited type channel protein gene is arranged, with such neuron of excitement with blue light; And stimulate expression that the neuron of inhibition type channel protein gene is arranged with gold-tinted, will suppress such neuron.Just can regulate and control neural circuit by excited or inhibition, thereby reach treatment damaged nerve tissue, reinvent the purpose of function of nervous system.
In one embodiment, as shown in Figure 2, above-mentioned therapy equipment with target function except comprising central control module 10, slow release module 20, signal acquisition module 30, photostimulation module 40 and optical fiber 50, also comprises electricity irritation module 60, electrode 70 and power module (not shown).Central control module 10 control electricity irritation modules 60 are carried out electricity irritation by electrode 70.Electricity irritation module 60 is to utilize brain stereotactic operation a certain specific position implant electrode 70 in brain, by producing electric current or potential pulse brain deep nerve nucleus is stimulated, central control module 10 adjustable current intensity and potential pulse frequency make it reach the effect of killing tumor cell.The electrical stimulating therapy that electricity irritation module 60 produces can be used as replenishing of photostimulation therapy.In addition, electrode 70 and optical fiber 50 can combine.
Power module provides electric energy for central control module 10, slow release module 20, signal acquisition module 30, photostimulation module 40, electricity irritation module 60 and electrode 70.Power module 80 can be one or more in one-shot battery, secondary cell and the radio frequency powered module.Wherein, one-shot battery can be lithium battery, silver oxide cell or biological fuel cell (providing electric energy as the glucose by enzyme catalysis self); Secondary cell can be lithium ion battery or lithium polymer battery.The radio frequency powered module is responded to and is produced electric energy by implanting in vivo coil.For stable more and persistent power supply, radio frequency powered module and biological fuel cell all can use with secondary cell, are its charging.
Above-mentioned work process with therapy equipment of target function is: central control module 10 controlling slow release modules 20 discharge targeting photoactive material and photaesthesia gene, first laser instrument of photostimulation module 40 produces the ultraviolet excitation targeting photoactive material of 300～400 nanometers, it is had an effect in tumor cell, killing tumor cell, signal acquisition module 20 is gathered bio signal, and send to central control module 10, the bio signal of 10 pairs of collections of central control module carries out analyzing and processing and generates relevant parameters, again by this parameter adjustment photostimulation module 40, further killing tumor cell, second laser instrument of photostimulation module 40 and the 3rd laser instrument produce blue light respectively and gold-tinted exciting light sensitive gene is expressed in target cell, thereby reach treatment nervous tissue, reinvent the purpose of function of nervous system.
Above-mentioned therapy equipment with target function, adopt slow release module 20 to discharge the targeting photoactive material in tumor cell, photostimulation module 40 produces laser excitation targeting photoactive material, killing tumor cell, because of the targeting photoactive material can accurately enter tumor cell, and do not enter normal cell, when adopting laser excitation targeting photoactive material, can reduce destruction, improve therapeutic effect patient's normal structure.
In addition, adopt slow release module 20 to discharge the photaesthesia gene to nervous tissue, photostimulation module 40 produces the gene expression of laser excitation photaesthesia, and repair is played by nervous tissue, has reduced more normal disorganization; Slow release module 20 also can discharge neurotrophic factor and promote neural growth and activity, or discharges the microcirculation that angiogenesis factor strengthens the focus zone, promotes the reparation of lesion tissue, thereby promotes the reparation of normal structure more; Adopt the passive target photoactive material, can carry out recyclingly, reduced medicine to the harmful effect of human body with saved the treatment cost; Adopt electricity irritation module 60 and electrode 70 to realize the supplementary means of electronic stimulation, improved therapeutic effect as the photostimulation treatment.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that for the person of ordinary skill of the art without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.

Claims (14)

1. therapy equipment with target function, it is characterized in that: comprise central control module, photostimulation module, optical fiber, signal acquisition module and slow release module, described central control module is controlled described photostimulation module, signal acquisition module and slow release module; Described slow release module is used to discharge targeting photoactive material and/or photaesthesia gene; Described photostimulation module produces laser and by described optical fiber described targeting photoactive material and/or photaesthesia gene is carried out photostimulation; Described signal acquisition module is used to gather the bio signal through in the focal zone before and after the photostimulation, and send to described central control module, described central control module generates relevant parameters to described bio signal analyzing and processing, controls described photostimulation module and slow release module respectively according to described parameter.
2. the therapy equipment with target function according to claim 1, it is characterized in that: described photostimulation module comprises the first light source device, secondary light source device and the 3rd light source device, the described first light source device excites described targeting photoactive material by described optical fiber, and described secondary light source device and the 3rd light source device excite described photaesthesia gene by described optical fiber.
3. the therapy equipment with target function according to claim 2 is characterized in that: it is the ultraviolet light of 300～400 nanometers that the described first light source device produces wave-length coverage.
4. the therapy equipment with target function according to claim 2 is characterized in that: it is the blue light of 473 nanometers that described secondary light source produces wavelength, and it is the gold-tinted of 594 nanometers that described the 3rd light source produces wavelength.
5. the therapy equipment with target function according to claim 1 is characterized in that: described targeting photoactive material comprises one or both in active targeting photoactive material and the passive target photoactive material.
6. the therapy equipment with target function according to claim 5 is characterized in that: described active targeting photoactive material comprises through finishing, antibody-mediated or receptor-mediated photosensitive agents.
7. the therapy equipment with target function according to claim 5 is characterized in that: described passive target photoactive material comprises one or more in nano titanium oxide, nano zine oxide, CNT, Graphene, fullerene, the organic photoelectrical material.
8. the therapy equipment with target function according to claim 5 is characterized in that: the size of described passive target photoactive material is less than 100 nanometers.
9. the therapy equipment with target function according to claim 1 is characterized in that: described slow release module also is used for discharging one or both of neurotrophic factor, angiogenesis factor.
10. the therapy equipment with target function according to claim 1 is characterized in that: described signal acquisition module comprises one or more in electrical signal collection unit, light signal collection unit, chemical sensor, the biosensor.
11. the therapy equipment with target function according to claim 1 is characterized in that: described bio signal comprises one or more in electricity physiological signal, optical signal, temperature, pH value, blood sugar concentration, oxygen concentration, the ion concentration.
12. the therapy equipment with target function according to claim 1, it is characterized in that: described therapy equipment with target function also comprises electrical stimulation device and electrode, described central control module is controlled described electrical stimulation device, and described electrical stimulation device carries out electricity irritation by described electrode.
13. the therapy equipment with target function according to claim 1, it is characterized in that: described therapy equipment with target function also comprises power module, and described power module is used to described central control module, photostimulation module, signal acquisition module and slow release module that electric energy is provided.
14. the therapy equipment with target function according to claim 13 is characterized in that: described power module is one or more in one-shot battery, secondary cell and the radio frequency powered module.
CN 201010557946 2010-11-24 2010-11-24 Therapy equipment with targeting function Pending CN102039007A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102277297A (en) * 2011-08-16 2011-12-14 中国科学院深圳先进技术研究院 Implanted in vivo electrotransfection device
CN102764481A (en) * 2012-07-13 2012-11-07 中国科学院深圳先进技术研究院 Photostimulation device and method for adjusting photostimulation temperature
CN107789743A (en) * 2016-08-31 2018-03-13 北京至感传感器技术研究院有限公司 Noninvasive therapeutic apparatus for treating tumor
CN109621223A (en) * 2019-01-30 2019-04-16 广东工业大学 A kind of light stimulus system
CN114849060A (en) * 2022-05-07 2022-08-05 江苏省人民医院（南京医科大学第一附属医院） Application of electrical stimulation in regulating and controlling MDK in organism

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CN101209349A (en) * 2006-12-27 2008-07-02 中国科学院大连化学物理研究所 Application of carbon nano-tube as carrier in transferring anti-cancer medicine
CN101269257A (en) * 2007-03-20 2008-09-24 深圳市微创医学科技有限公司 Optical power therapentic equipment
CN101569778A (en) * 2009-03-10 2009-11-04 深圳先进技术研究院 Biofeedback simulation system and biofeedback simulation method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101209349A (en) * 2006-12-27 2008-07-02 中国科学院大连化学物理研究所 Application of carbon nano-tube as carrier in transferring anti-cancer medicine
CN101269257A (en) * 2007-03-20 2008-09-24 深圳市微创医学科技有限公司 Optical power therapentic equipment
CN101569778A (en) * 2009-03-10 2009-11-04 深圳先进技术研究院 Biofeedback simulation system and biofeedback simulation method

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102277297A (en) * 2011-08-16 2011-12-14 中国科学院深圳先进技术研究院 Implanted in vivo electrotransfection device
CN102277297B (en) * 2011-08-16 2013-06-05 中国科学院深圳先进技术研究院 Implanted in vivo electrotransfection device
CN102764481A (en) * 2012-07-13 2012-11-07 中国科学院深圳先进技术研究院 Photostimulation device and method for adjusting photostimulation temperature
CN102764481B (en) * 2012-07-13 2015-04-15 中国科学院深圳先进技术研究院 Photostimulation device and method for adjusting photostimulation temperature
CN107789743A (en) * 2016-08-31 2018-03-13 北京至感传感器技术研究院有限公司 Noninvasive therapeutic apparatus for treating tumor
CN109621223A (en) * 2019-01-30 2019-04-16 广东工业大学 A kind of light stimulus system
CN114849060A (en) * 2022-05-07 2022-08-05 江苏省人民医院（南京医科大学第一附属医院） Application of electrical stimulation in regulating and controlling MDK in organism
CN114849060B (en) * 2022-05-07 2023-08-25 江苏省人民医院（南京医科大学第一附属医院） Application of electric stimulation in regulation and control of MDK in organism

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Application publication date: 20110504