CN102764481B - Photostimulation device and method for adjusting photostimulation temperature - Google Patents
Photostimulation device and method for adjusting photostimulation temperature Download PDFInfo
- Publication number
- CN102764481B CN102764481B CN201210243620.9A CN201210243620A CN102764481B CN 102764481 B CN102764481 B CN 102764481B CN 201210243620 A CN201210243620 A CN 201210243620A CN 102764481 B CN102764481 B CN 102764481B
- Authority
- CN
- China
- Prior art keywords
- temperature sensor
- processing unit
- central processing
- temperature
- photostimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Thermotherapy And Cooling Therapy Devices (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to a photostimulation device which comprises a temperature sensor, a central processing unit, a drug feeding device, a refrigerating device, and a micro guide tube. The temperature sensor is used for detecting temperature of nerve tissues. The central processing unit which is connected with the temperature sensor is used for receiving feedback temperature information of the temperature sensor. The drug feeding device which is connected with the central processing unit is used for filling solution. The refrigerating device which is connected with the central processing unit and the drug feeding device are used for refrigerating the solution filled by the drug feeding device. The micro guide tube which is connected with the refrigerating device is used for conveying the refrigerated solution to the nerve tissues. The central processing unit is further used for adjusting parameters of solution filled by the drug feeding device according to the feedback temperature information of the temperature sensor and adjusting refrigerating parameters of solution refrigerated by the refrigerating device. In addition, the invention further provides a method for adjusting photostimulation temperature. By the photostimulation device and the method, radiation and cooling in the photostimulation can be achieved.
Description
Technical field
The present invention relates to medical instruments field, the method for temperature when particularly relating to a kind of light stimulation device and regulate photostimulation.
Background technology
Worldwide nervous system disease and mental sickness have become two hang-ups of society.Comprise epilepsy, Parkinson's disease, schizophrenia, anorexia nervosa, depression, senile dementia, tremble, numerous central nervous systems of spasm, obsession, anxiety neurosis, apoplexy and drug addiction etc. mental sickness of unifying threatens human health, puzzlement human normal life always.And the appearance of light genetics technology (Optogenetics) allows the solution making the problems referred to above become possibility.
Light genetics technology is the biotechnology that of developing rapidly in recent years incorporates a kind of brand-new multi-crossed disciplines of optics, genetic engineering, electro physiology and electronic engineering.Its cardinal principle first adopts gene technology to be transferred in the cell of particular type in nervous system by light sensation gene to express, and makes it on cell membrane, form special ion channel.These ion channels under the photostimulation of different wave length can respectively to cation or anion by producing selectivity, the transmembrane potential on cell membrane both sides is caused to change, excited or the suppression to cell selective ground, thus reach the object for the treatment of nervous system disease and mental sickness.
But the light stimulation device in conventional art is when carrying out photostimulation by fiber optic conduction light, and optical fiber can produce heat and make temperature raise gradually.And nervous tissue is more responsive to temperature, the therapeutic effect of photostimulation can be affected.The thermal diffusivity of the light stimulation device therefore in conventional art is poor.
Summary of the invention
Based on this, be necessary to provide a kind of thermal diffusivity good light stimulation device.
A kind of light stimulation device, comprising:
Temperature sensor, for detecting the temperature of nervous tissue;
Central processing unit, is connected with described temperature sensor, for receiving the temperature information of described temperature sensor feedback;
Doser, is connected with described central processing unit, for primer solution;
Refrigerating plant, is connected with central processing unit and described doser, for the solution of described doser perfusion of freezing;
Microtubular, is connected with refrigerating plant, for by refrigeration after fluid delivery in nervous tissue;
Described central processing unit also for adjusting the parameter of described doser primer solution according to the temperature information of described temperature sensor feedback, and adjusts the cooling parameters that described refrigerating plant freezes to solution.
Wherein in an embodiment, also comprise:
Signal generator, is connected with described central processing unit, for generation of optical stimulus signal;
Light source, is connected with signal generator, for producing light beam according to optical stimulus signal;
Optical fiber, is connected with light source, for carrying out photostimulation to nervous tissue;
Described central processing unit is also for adjusting the parameter of the optical stimulus signal that described signal generator produces according to the temperature information of described temperature sensor feedback.
Wherein in an embodiment, described temperature sensor also comprises the detecting head for detected temperatures of tubulose, and described detecting head and described optical fiber, described microtubular are arranged in fascicular texture.
Wherein in an embodiment, the parameter of described optical stimulus signal comprises waveform and/or dutycycle.
Wherein in an embodiment, the parameter of described primer solution is flow rate of liquid, and described cooling parameters is refrigeration work consumption.
Wherein in an embodiment, described temperature sensor is at least one in thermocouple type temperature sensor, infrared temperature sensor, nano fluorescent sensor.
Wherein in an embodiment, the temperature information buffer memory of temperature sensor feedback of described master reference also for receiving, and in temperature higher than threshold value alarm.
In addition, the method for temperature when a kind of adjustment photostimulation of temperature when can reduce photostimulation is provided to provide.
A method for temperature when regulating photostimulation, comprising:
Obtain the temperature information being subject to the nervous tissue of photostimulation;
According to described temperature information primer solution;
Freeze according to the solution of described temperature information to described perfusion;
Described solution is imported described nervous tissue.
Wherein in an embodiment, described acquisition also comprises after being subject to the step of the temperature information of the nervous tissue of photostimulation:
Optical stimulus signal is regulated according to described temperature information;
Light beam is generated according to the optical stimulus signal after described adjustment;
By described light beam, photostimulation is carried out to described nervous tissue.
Wherein in an embodiment, the described step according to described temperature information adjustment optical stimulus signal is:
Waveform and/or the dutycycle of optical stimulus signal is regulated according to described temperature information.
Above-mentioned light stimulation device, with the addition of temperature sensor, central processing unit, doser, refrigerating plant and microtubular, central processing unit detects the temperature information being subject to the nervous tissue of photostimulation by temperature sensor, and produce the lower solution of temperature according to temperature information control doser, refrigerating plant, and by microtubular, this solution is imported to the place of nervous tissue being subject to photostimulation, thus serve the effect to nervous tissue's radiating and cooling.
After being connected with signal generator by central processing unit, central processing unit can regulate intensity and the duration of photostimulation according to the temperature information of temperature sensor feedback.Such as, when temperature is higher, reduce Stimulus light and duration; When the temperature is low, Stimulus light and duration is improved.Thus temperature is regulated, serve the effect of cooling.
Accompanying drawing explanation
Fig. 1 is the structural representation of light stimulation device in an embodiment;
Fig. 2 is the structural representation of light stimulation device in another embodiment;
The structural representation of the fascicular texture that Fig. 3 is temperature sensor in an embodiment, optical fiber, microtubular are arranged in;
Fig. 4 is the flow chart of the method for temperature when regulating photostimulation in an embodiment.
Detailed description of the invention
In one embodiment, as shown in Figure 1, a kind of light stimulation device, comprising: temperature sensor 102, the central processing unit 104 be connected with temperature sensor 102, the doser 106 be connected with central processing unit 104, the refrigerating plant 108 be connected with central processing unit 104 and doser 106, the microtubular 110 that is connected with refrigerating plant 108.Wherein:
Temperature sensor 102, for detecting the temperature of nervous tissue.
Central processing unit 104, for receiving the temperature information of temperature sensor 102 feedback.
Doser 106, for primer solution.
Refrigerating plant 108, is connected with central processing unit 104 and doser 106, for the solution that the doser 106 that freezes pours into.
Microtubular 110, for by refrigeration after fluid delivery in nervous tissue.
Central processing unit 104 is also for the parameter of temperature information adjustment doser 106 primer solution according to temperature sensor 102 feedback, and the cooling parameters that adjustment refrigerating plant 108 pairs of solution freeze.
Further, temperature sensor 102 can be at least one in thermocouple type temperature sensor, infrared temperature sensor, nano fluorescent sensor.
Further, the parameter of doser 106 primer solution is flow rate of liquid.
Further, the cooling parameters of refrigerating plant 108 is refrigeration work consumption.
Further, the solution of doser perfusion is cerebrospinal fluid.
Further, the temperature information buffer memory of temperature sensor 102 feedback of central processing unit 104 also for receiving, and in temperature higher than threshold value alarm.By luminous or sounding alarm.
Further, the certainty of measurement of temperature sensor 102 is less than 1 degree Celsius.
In one embodiment, as shown in Figure 2, light stimulation device also comprises the signal generator 112 be connected with central processing unit 104, the light source 114 be connected with signal generator 112, the optical fiber 116 that is connected with light source 114.Wherein:
Signal generator 112 is for generation of optical stimulus signal.
Light source 114 is for producing light beam according to optical stimulus signal.
Optical fiber 116 is for carrying out photostimulation to nervous tissue.
Central processing unit 104 is also for the parameter of the optical stimulus signal of temperature information adjustment signal generator 112 generation according to temperature sensor 102 feedback.
In the present embodiment, as shown in Figure 3, temperature sensor 102 is tubulose, and temperature sensor 102 and optical fiber 114, microtubular 110 are arranged in fascicular texture.When treating, by the tip of this fascicular texture contact nervous tissue, photostimulation can be carried out to nervous tissue.
Further, the parameter of optical stimulus signal comprises waveform and/or dutycycle.
Optical stimulus signal is the signal of telecommunication, and light source can produce according to this optical stimulus signal the light beam being used for photostimulation by opto-electronic conversion.
Above-mentioned light stimulation device, with the addition of temperature sensor, central processing unit, doser, refrigerating plant and microtubular, central processing unit detects the temperature information being subject to the nervous tissue of photostimulation by temperature sensor, and produce the lower solution of temperature according to temperature information control doser, refrigerating plant, and by microtubular, this solution is imported to the place of nervous tissue being subject to photostimulation, thus serve the effect to nervous tissue's radiating and cooling.
After being connected with signal generator by central processing unit, central processing unit can regulate intensity and the duration of photostimulation according to the temperature information of temperature sensor feedback.Such as, when temperature is higher, reduce Stimulus light and duration; When the temperature is low, Stimulus light and duration is improved.Thus temperature is regulated, serve the effect of cooling.
In one embodiment, as shown in Figure 4, a kind of method of temperature when regulating photostimulation, comprising:
Step S102, obtains the temperature information being subject to the nervous tissue of photostimulation.
In one embodiment, the temperature information being subject to the nervous tissue of photostimulation is obtained by temperature sensor.Temperature sensor can be at least one in thermocouple type temperature sensor, infrared temperature sensor, nano fluorescent sensor.
Step S104, according to temperature information primer solution.
In one embodiment, flow rate of liquid can be calculated according to temperature information, according to flow rate of liquid primer solution.In the present embodiment, doser primer solution is regulated by central processing unit according to temperature information.
Step S106, freezes according to the solution of described temperature information to described perfusion.
In one embodiment, refrigeration work consumption can be calculated according to temperature information, freeze according to the solution of refrigeration work consumption to perfusion.In the present embodiment, the solution of refrigerating plant to perfusion is regulated to freeze by central processing unit according to temperature information.
Step S108, imports nervous tissue by solution.
In one embodiment, by microtubular, solution is imported to the place of nervous tissue being subject to photostimulation.
In one embodiment, acquisition also can regulate optical stimulus signal according to temperature information after being subject to the step of the temperature information of the nervous tissue of photostimulation; Light beam is generated according to the optical stimulus signal after regulating; By light beam photostimulation is carried out to nervous tissue.
In the present embodiment, the step of optical stimulus signal is regulated to be specially according to temperature information: the waveform and/or the dutycycle that regulate optical stimulus signal according to temperature information.
The method of temperature during above-mentioned adjustment photostimulation, obtains the temperature information being subject to the nervous tissue of photostimulation, after temperature information perfusion and refrigerant solution, solution is imported nervous tissue, serves the effect to nervous tissue's radiating and cooling.
Meanwhile, regulate optical stimulus signal according to temperature information, generate light beam according to the optical stimulus signal after regulating; By light beam photostimulation is carried out to nervous tissue.Make the intensity of photostimulation and duration can be adjusted according to temperature information, thus serve the effect of cooling further.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (6)
1. a light stimulation device, is characterized in that, comprising:
Temperature sensor, for detecting the temperature of nervous tissue;
Central processing unit, is connected with described temperature sensor, for receiving the temperature information of described temperature sensor feedback;
Doser, is connected with described central processing unit, for primer solution;
Refrigerating plant, is connected with central processing unit and described doser, for the solution of described doser perfusion of freezing;
Microtubular, is connected with refrigerating plant, for by refrigeration after fluid delivery in nervous tissue;
Described central processing unit also for adjusting the parameter of described doser primer solution according to the temperature information of described temperature sensor feedback, and adjusts the cooling parameters that described refrigerating plant freezes to solution;
Signal generator, is connected with described central processing unit, for generation of optical stimulus signal;
Light source, is connected with signal generator, for producing light beam according to optical stimulus signal;
Optical fiber, is connected with light source, for carrying out photostimulation to nervous tissue;
Described central processing unit is also for adjusting the parameter of the optical stimulus signal that described signal generator produces according to the temperature information of described temperature sensor feedback.
2. light stimulation device according to claim 1, is characterized in that, described temperature sensor also comprises the detecting head for detected temperatures of tubulose, and described detecting head and described optical fiber, described microtubular are arranged in fascicular texture.
3. light stimulation device according to claim 1, is characterized in that, the parameter of described optical stimulus signal comprises waveform and/or dutycycle.
4. light stimulation device according to claim 1, is characterized in that, the parameter of described primer solution is flow rate of liquid, and described cooling parameters is refrigeration work consumption.
5. light stimulation device according to claim 1, is characterized in that, described temperature sensor is at least one in thermocouple type temperature sensor, infrared temperature sensor, nano fluorescent sensor.
6. light stimulation device according to claim 1, is characterized in that, the temperature information buffer memory of temperature sensor feedback of described master reference also for receiving, and in temperature higher than threshold value alarm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210243620.9A CN102764481B (en) | 2012-07-13 | 2012-07-13 | Photostimulation device and method for adjusting photostimulation temperature |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210243620.9A CN102764481B (en) | 2012-07-13 | 2012-07-13 | Photostimulation device and method for adjusting photostimulation temperature |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102764481A CN102764481A (en) | 2012-11-07 |
| CN102764481B true CN102764481B (en) | 2015-04-15 |
Family
ID=47092202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210243620.9A Active CN102764481B (en) | 2012-07-13 | 2012-07-13 | Photostimulation device and method for adjusting photostimulation temperature |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102764481B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103071244B (en) * | 2013-01-25 | 2015-09-16 | 深圳先进技术研究院 | For the wireless remote control light stimulus system of animal |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569778A (en) * | 2009-03-10 | 2009-11-04 | 深圳先进技术研究院 | Biofeedback simulation system and biofeedback simulation method |
| CN102019040A (en) * | 2010-11-29 | 2011-04-20 | 中国科学院深圳先进技术研究院 | Biofeedback photoelectric therapeutic device |
| CN102039007A (en) * | 2010-11-24 | 2011-05-04 | 中国科学院深圳先进技术研究院 | Therapy equipment with targeting function |
| CN102380170A (en) * | 2011-08-16 | 2012-03-21 | 中国科学院深圳先进技术研究院 | Implanted photoelectrode collecting, regulating and controlling device |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030083716A1 (en) * | 2001-10-23 | 2003-05-01 | Nicolelis Miguel A.L. | Intelligent brain pacemaker for real-time monitoring and controlling of epileptic seizures |
-
2012
- 2012-07-13 CN CN201210243620.9A patent/CN102764481B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101569778A (en) * | 2009-03-10 | 2009-11-04 | 深圳先进技术研究院 | Biofeedback simulation system and biofeedback simulation method |
| CN102039007A (en) * | 2010-11-24 | 2011-05-04 | 中国科学院深圳先进技术研究院 | Therapy equipment with targeting function |
| CN102019040A (en) * | 2010-11-29 | 2011-04-20 | 中国科学院深圳先进技术研究院 | Biofeedback photoelectric therapeutic device |
| CN102380170A (en) * | 2011-08-16 | 2012-03-21 | 中国科学院深圳先进技术研究院 | Implanted photoelectrode collecting, regulating and controlling device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102764481A (en) | 2012-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102380170B (en) | Implanted photoelectrode collecting, regulating and controlling device | |
| Goncalves et al. | Design and manufacturing challenges of optogenetic neural interfaces: a review | |
| C Thompson et al. | Optical stimulation of neurons | |
| WO2009020862A3 (en) | Vestibular stimulation apparatus and associated methods of use | |
| US20140324138A1 (en) | Wirelessly-powered illumination of biological tissue | |
| WO2009030355A3 (en) | Device and method for producing electrically conductive nanostructures by means of electrospinning | |
| CN104093448A (en) | Modulating function of neural structures near the ear | |
| JP2014508553A5 (en) | ||
| JP2013502279A5 (en) | ||
| WO2009108950A3 (en) | Temperature profile mapping and guided thermotherapy | |
| CN109717830B (en) | Fatigue detection and wake-up promotion system based on eye movement and head movement parameter monitoring | |
| CN102764481B (en) | Photostimulation device and method for adjusting photostimulation temperature | |
| CN110180085B (en) | Direct-insertion type semiconductor red light internal-emission rhinitis auxiliary phototherapy instrument | |
| CN102277297B (en) | Implanted in vivo electrotransfection device | |
| WO2004080281A3 (en) | Method and apparatus for control of skin perfusion for indirect glucose measurement | |
| KR102430239B1 (en) | Wearable device for caring hypertension and method for opertating wearable device for caring hypertension | |
| Leston | Functional anatomy of the trigeminal nerve | |
| RU2015149389A (en) | THERAPY SYSTEM FOR ENERGY SUPPLY | |
| CN203914882U (en) | The monitoring of tumor Hyperthermia skin temperature and protection system | |
| US20240189505A1 (en) | Hybrid bioelectronic/engineered cell wearable system for therapeutic agents delivery and applications thereof | |
| CN204890175U (en) | Holing position check out test set that pedicle of vertebral arch screw implantation was used | |
| CN103584839B (en) | A kind of pain sense stimulation instrument and its implementation | |
| CN103356177A (en) | Electronic clinical thermometer with peak measurement mode and real-time monitoring mode, and measurement method thereof | |
| CN204698987U (en) | A kind of gassing machine medical system based on cloud service | |
| CN118177963A (en) | Laser ablation method, apparatus, device and computer readable storage medium |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |