CN103584839B - A kind of pain sense stimulation instrument and its implementation - Google Patents
A kind of pain sense stimulation instrument and its implementation Download PDFInfo
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- CN103584839B CN103584839B CN201310593485.5A CN201310593485A CN103584839B CN 103584839 B CN103584839 B CN 103584839B CN 201310593485 A CN201310593485 A CN 201310593485A CN 103584839 B CN103584839 B CN 103584839B
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Abstract
The invention provides a kind of pain sense stimulation instrument and its implementation, described pain sense stimulation instrument comprises dual-wavelength laser module, Laser Power Devices, control circuit board, water cooling unit, mechanical light path, infrared imaging monitoring modular and PC; This pain sense stimulation instrument, according to different optical maser wavelength penetrate human body surface act on human body skin pain nerve produce photo-thermal stimulate pain principle make, make measurement result more accurate, adopt the excited nociceptor of non-contacting mode specificity, sensation intensity is adjustable, also can not can not produce injury to health by skin ambustion, eliminate patient's misery while safety stimulates, decrease the probability of infection and Blood spread disease, there is high clinical application.
Description
Technical field
The present invention relates to medical apparatus and instruments and its implementation of a kind of system that excites nerve, especially a kind of pain sense stimulation instrument and its implementation.
Background technology
The pain sensation is that organism comes to harm the sensation that sexual stimulus produces.There is important biological significance.Be the warning system of organism inside, can defensive reaction be caused, there is protective effect.The pain sensation, can be divided into dermatodynia, and from deep pain and the Encelialgia in muscle, tendon and joint, they respectively have feature.The pain sensation acquires a certain degree, usually can with certain physiological change and offending emotional response.The pain sensation or the pain reaction of people have larger individual difference.Someone pain susceptibility is low, has people Ze Gao.The individual difference that the pain sensation is larger has much relations with the psychological factor producing the pain sensation.The pain sensation is in nationality, sex, also also exist certain difference in the age.
Visible, organism feels to there is individual variation for pain, in some clinical researches, Diagnosis and Treat process, such as, analgesic, anesthesia therapeutic evaluation, the study mechanism of charcot marie tooth neuropathic pain, Laser evoked potentials technology and the intervention of pain intuition is used to carry out entirety sleep and the quick mobile sleep study of eyeball, the aspect such as intravertebral anesthesia and nerve block anesthesia, by the stimulation to organism pain nerve, utilize its pain by making objective to dosage, therapeutic effect etc. and have the assessment of directive significance.
Present stage, the method of organism being carried out to pain stimulus mainly comprises: needle point method, electrostimulation and thermal source stimulus method, but, needle point method often causes patient inaccurate on pain stimulation impression impact because acupuncture dynamics is non-constant, electrostimulation and thermal source stimulus method make to stimulate area large, stimulate the degree of depth to be difficult to control, thus accurately can not stimulate and need stimulation location.Therefore, study a kind of new pain stimulus device, stimulate in safety and organicly obtain measurement result accurately simultaneously, very important value of clinical studies will be had.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of pain sense stimulation instrument.
Another technical problem to be solved by this invention is the implementation method providing above-mentioned pain sense stimulation instrument.
For solving the problems of the technologies described above, technical scheme of the present invention is:
A kind of pain sense stimulation instrument, comprises dual-wavelength laser module, Laser Power Devices, control circuit board, water cooling unit, mechanical light path, infrared imaging monitoring modular and PC, wherein,
Dual-wavelength laser module, is coupled to form by fiber coupler primarily of 980nm laser instrument (generation pulse current) and 1940nm laser instrument (generation continuous current);
Laser Power Devices, are connected with dual-wavelength laser module circuitry;
Water cooling unit is water-cooled platform loop supply cooling water by water-cooled interface, and described dual-wavelength laser module to be placed on water-cooled platform and to carry out glue with indium and connects and heat conduction;
Control circuit board, is DAQ V1.0 data collecting card, is connected by IO delivery outlet with DA delivery outlet with 15 pin control ports of Laser Power Devices, to control the parameters such as the energy of Laser output, pulsewidth and cycle, and described control circuit board and water cooling unit control connection simultaneously;
Machinery light path, protect armour optical fiber, collimating mirror and mirror holder by band to form, described band protects armour Fiber connection dual-wavelength laser module, by being with the light-output protecting armour optical fiber and dual-wavelength laser module produced, and protect armour optical fiber connector at this band and be fixed with collimating mirror by mirror holder, ensure beam quality when irradiating by collimating mirror;
Infrared imaging monitoring modular, is made up of infrared imaging monitor and PLC communication module connection, for the temperature signal detected is returned PC with the form of 4 hexadecimal digits, as calculated afterwards for alarm or control laser power;
PC, with the PLC communication module connection of infrared imaging monitoring modular, simultaneously this PC and control circuit board connection.
Preferably, above-mentioned pain sense stimulation instrument, described dual-wavelength laser module also comprises instruction light source, and described instruction light source is made up of in the mode of coupling fiber the semiconductor laser light resource of a 632nm and a LED.
Preferably, above-mentioned pain sense stimulation instrument, described dual-wavelength laser module and Laser Power Devices line connection are that dual-wavelength laser module is connected with five pin aviation sockets with 232 interfaces by wire, a quasi-continuous semiconductor laser power supply J-QCW4212(pulse current) and a uninterruptable power J-CW5006(continuous current) Power supply line be integrated in aviation plug, power to dual-wavelength laser module by connecting described five pin aviation sockets.
Preferably, above-mentioned pain sense stimulation instrument, described water cooling unit is the BILON-T-1001 water cooling unit of 800W.
Preferably, above-mentioned pain sense stimulation instrument, the mirror holder of described mechanical light path is also provided with adnexa, and described adnexa comprises for the dust-proof and blower fan of the band filter screen that designs, dust cover and for controlling attenuator, optics wedge and the micro-step motor connector added by light path.
Preferably, above-mentioned pain sense stimulation instrument, the model of described infrared imaging monitor is online monitor WX-150.
Preferably, above-mentioned pain sense stimulation instrument, the model of described PLC communication module is Mitsubishi PLC communication module FX1N-485-BD FX3U-485-BD FX2N.
Above-mentioned pain sense stimulation instrument carries out the implementation method of laser stimulation to organism, and concrete steps are as follows:
LEPS pattern (laser evoked potentials, Laser evoked potentials, the pattern utilizing pulse laser evoked brain potential) under, system initialization, carry out pulse width, the initial setting up of pulse frequency and pulse energy also checks that hydraulic pressure is protected, whether original state is normal, outer signal is frequently utilized to control output pulse waveform, and start timing in the moment starting to export, and send synchronization pulse to electroencephalograph, on each time point, the EEG signals detected is recorded by electroencephalograph, and when LEPS terminates by the signal storage that detects to PC, conveniently carry out computing, and/or
(1) CHEP pattern (Contact heat evoked potentials, contact thermostimulation pattern, it is the pattern of carrying out thermostimulation with heat dish, the laser that this refers to export continuously stimulates, the temperature curve of simulation CHEP carries out the mode stimulated) under, system initialization, mainly carry out the setting of preset temperature and temperature rising-time, by these two numerical value, through the corresponding relation being determined laser power and temperature value by experiment that converts, preset temperature and temperature rising-time are found out corresponding baseline laser power and boost pulse laser power, determine Output of laser pattern, obtain the laser output power needing modulation, meanwhile, the detection carrying out original state is also needed,
(2) under CHEP pattern, infrared imaging monitor is utilized to test illuminated subject surface temperature, and temperature value is sent to PC, and then regulation and control control circuit board, according to temperature rise speed and surface temperature, improve or reduce the power of Output of laser, finally reaching the time of pain stimulus, intensity is controlled effect.
The invention has the beneficial effects as follows:
Above-mentioned pain sense stimulation instrument, according to different optical maser wavelength penetrate human body surface act on human body skin pain nerve produce photo-thermal stimulate pain principle make, make measurement result more accurate, adopt the excited nociceptor of non-contacting mode specificity, sensation intensity is adjustable, also can not can not produce injury to health by skin ambustion, eliminate patient's misery while safety stimulates, decrease the probability of infection and Blood spread disease, there is high clinical application.
Accompanying drawing explanation
Fig. 1 is the anatomical connectivity relation block diagram of pain sense stimulation instrument of the present invention;
Fig. 2 is that pain sense stimulation instrument of the present invention carries out the workflow diagram of laser stimulation to organism.
Detailed description of the invention
In order to make those skilled in the art better understand technical scheme of the present invention, below in conjunction with the drawings and the specific embodiments, technical scheme of the present invention is described in further detail.
Embodiment 1
As shown in Figure 1, a kind of pain sense stimulation instrument, comprises dual-wavelength laser module, Laser Power Devices, control circuit board, the BILON-T-1001 water cooling unit of 800W, mechanical light path, infrared imaging monitoring modular and PC, wherein,
Dual-wavelength laser module, 1940nm laser instrument (generation continuous current) primarily of the independently quasi-continuous 980nm laser instrument of 150W (generation pulse current) and 3 5W is coupled to form by fiber coupler, simultaneously, also have instruction light source, described instruction light source is made up of in the mode of coupling fiber the semiconductor laser light resource of a 632nm and a green LED lamp;
Laser Power Devices, be connected with dual-wavelength laser module circuitry, connected mode is that dual-wavelength laser module is connected with five pin aviation sockets with 232 interfaces by wire, the Power supply line of a quasi-continuous semiconductor laser power supply J-QCW4212 and uninterruptable power J-CW5006 is integrated in aviation plug, powers to dual-wavelength laser module by connecting described five pin aviation sockets;
Water cooling unit is water-cooled platform loop supply cooling water by water-cooled interface, and described dual-wavelength laser module to be placed on water-cooled platform and to carry out glue with indium and connects and heat conduction;
Control circuit board, is DAQ V1.0 data collecting card, is connected by IO delivery outlet with DA delivery outlet with 15 pin control ports of Laser Power Devices, to control the parameters such as the energy of Laser output, pulsewidth and cycle, and described control circuit board and water cooling unit control connection simultaneously;
Machinery light path, protect armour optical fiber, collimating mirror and mirror holder by band to form, described band protects armour Fiber connection dual-wavelength laser module, by being with the light-output protecting armour optical fiber and dual-wavelength laser module produced, and protect armour optical fiber connector at this band and be fixed with collimating mirror by mirror holder, ensure beam quality when irradiating by collimating mirror; In addition, the mirror holder of described mechanical light path can also arrange adnexa, described adnexa comprises for the dust-proof and blower fan of the band filter screen that designs, dust cover and for controlling attenuator, optics wedge and the micro-step motor connector added by light path;
Infrared imaging monitoring modular, be made up of infrared imaging monitor and Mitsubishi PLC communication module FX1N-485-BD FX3U-485-BD FX2N connection, wherein, the model of described infrared imaging monitor is online monitor WX-150, the temperature signal that PLC communication module is used for infrared imaging monitor to detect returns PC with the form of 4 hexadecimal digits, as calculated afterwards for alarm or control laser power;
PC, with the PLC communication module connection of infrared imaging monitoring modular, simultaneously this PC and control circuit board connection.
As shown in Figure 2, above-mentioned pain sense stimulation instrument carries out the implementation method of laser stimulation to organism, and concrete steps are as follows:
LEPS pattern (laser evoked potentials, Laser evoked potentials, the pattern utilizing pulse laser evoked brain potential) under, system initialization, carry out pulse width, the initial setting up of pulse frequency and pulse energy also checks that hydraulic pressure is protected, whether original state is normal, outer signal is frequently utilized to control output pulse waveform, and start timing in the moment starting to export, and send synchronization pulse to electroencephalograph, on each time point, the EEG signals detected is recorded by electroencephalograph, and when LEPS terminates by the signal storage that detects to PC, conveniently carry out computing, and/or
(1) CHEP pattern (Contact heat evoked potentials, contact thermostimulation pattern, it is the pattern of carrying out thermostimulation with heat dish, the laser that this refers to export continuously stimulates, the temperature curve of simulation CHEP carries out the mode stimulated) under, system initialization, mainly carry out the setting of preset temperature and temperature rising-time, by these two numerical value, through the corresponding relation being determined laser power and temperature value by experiment that converts, preset temperature and temperature rising-time are found out corresponding baseline laser power and boost pulse laser power, determine Output of laser pattern, obtain the laser output power needing modulation, meanwhile, the detection carrying out original state is also needed,
(2) under CHEP pattern, infrared imaging monitor is utilized to test illuminated subject surface temperature, and temperature value is sent to PC, and then regulation and control control circuit board, according to temperature rise speed and surface temperature, improve or reduce the power of Output of laser, finally reaching the time of pain stimulus, intensity is controlled effect.
Because 976nm laser penetration depth is in skin comparatively dark, can produce heat under the pattern of not injured skin stimulates darker nociception; 1940nm laser is an absworption peak on the water, just absorbed and stimulated to depths heat by conduction skin table is shallow, in the dual-wavelength laser module of described pain sense stimulation instrument, the generation of dual-wavelength laser adopts 1940nm continuous laser and frequency multiplication to obtain 976nm pulse laser, stimulates the Pain receptor that table is shallow.Due to energy, the burst length is adjustable, therefore can carry out when more accurate, high duplication the control that the pain sensation brings out signal.And the temperature that can control irradiating surface by dual-wavelength laser carries out regulating (above-mentioned several temperature is the threshold value that nociception receptor is activated) in 43 DEG C, 48 DEG C and 52 DEG C of these intervals, thus can control to stimulate Pain receptor A δ fiber and fiber C respectively, in this judgement at clinical disease and basic research, there is higher practical value.
Above-mentioned detailed description of this kind of pain sense stimulation instrument and its implementation being carried out with reference to detailed description of the invention; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (7)
1. a pain sense stimulation instrument, is characterized in that: comprise dual-wavelength laser module, Laser Power Devices, control circuit board, water cooling unit, mechanical light path, infrared imaging monitoring modular and PC, wherein,
Dual-wavelength laser module, is coupled to form by fiber coupler primarily of 980nm laser instrument and 1940nm laser instrument;
Laser Power Devices, are connected with dual-wavelength laser module circuitry;
Water cooling unit is water-cooled platform loop supply cooling water by water-cooled interface, and described dual-wavelength laser module to be placed on water-cooled platform and to carry out glue with indium and connects and heat conduction;
Control circuit board, is DAQ V1.0 data collecting card, is connected by IO delivery outlet with DA delivery outlet with 15 pin control ports of Laser Power Devices, simultaneously described control circuit board and water cooling unit control connection;
Machinery light path, protect armour optical fiber, collimating mirror and mirror holder by band to form, described band protects armour Fiber connection dual-wavelength laser module, by being with the laser derivation protected armour optical fiber and dual-wavelength laser module produced, this band protects armour optical fiber connector and is fixed with collimating mirror by mirror holder, ensures beam quality when irradiating by collimating mirror;
Infrared imaging monitoring modular, is made up of infrared imaging monitor and PLC communication module connection, for the temperature signal detected is returned PC with the form of 4 hexadecimal digits, as calculated afterwards for alarm or control laser power;
PC, with the PLC communication module connection of infrared imaging monitoring modular, simultaneously this PC and control circuit board connection.
2. pain sense stimulation instrument according to claim 1, is characterized in that: described dual-wavelength laser module also comprises instruction light source, and described instruction light source is made up of in the mode of coupling fiber the semiconductor laser light resource of a 632nm and a LED.
3. pain sense stimulation instrument according to claim 1, it is characterized in that: described dual-wavelength laser module and Laser Power Devices line connection are that dual-wavelength laser module is connected with five pin aviation sockets with 232 interfaces by wire, the Power supply line of a quasi-continuous semiconductor laser power supply J-QCW4212 and uninterruptable power J-CW5006 is integrated in aviation plug, powers to dual-wavelength laser module by connecting described five pin aviation sockets.
4. pain sense stimulation instrument according to claim 1, is characterized in that: described water cooling unit is the BILON-T-1001 water cooling unit of 800W.
5. pain sense stimulation instrument according to claim 1, it is characterized in that: the mirror holder of described mechanical light path is also provided with adnexa, described adnexa comprises for the dust-proof and blower fan of the band filter screen that designs, dust cover and for controlling attenuator, optics wedge and the micro-step motor connector added by light path.
6. pain sense stimulation instrument according to claim 1, is characterized in that: the model of described infrared imaging monitor is online monitor WX-150.
7. pain sense stimulation instrument according to claim 1, is characterized in that: the model of described PLC communication module is Mitsubishi PLC communication module FX1N-485-BD FX3U-485-BDFX2N.
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| CN105456024A (en) * | 2015-12-30 | 2016-04-06 | 中国医学科学院生物医学工程研究所 | Double-wavelength multi-channel laser acupuncture and moxibustion instrument |
| CN110811631B (en) * | 2019-11-07 | 2022-07-12 | 重庆市江津区中心医院 | Pain measuring instrument device for anesthesia department |
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| CN101360460A (en) * | 2006-01-20 | 2009-02-04 | 住友电气工业株式会社 | Imaging system |
| CN101569778A (en) * | 2009-03-10 | 2009-11-04 | 深圳先进技术研究院 | Biofeedback simulation system and biofeedback simulation method |
| CN203677059U (en) * | 2013-11-21 | 2014-07-02 | 中国医学科学院生物医学工程研究所 | Algesia stimulator |
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| US8792978B2 (en) * | 2010-05-28 | 2014-07-29 | Lockheed Martin Corporation | Laser-based nerve stimulators for, E.G., hearing restoration in cochlear prostheses and method |
| US20110282334A1 (en) * | 2010-05-11 | 2011-11-17 | Ceramoptec Industries Inc. | Device and method for fistula treatment |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101360460A (en) * | 2006-01-20 | 2009-02-04 | 住友电气工业株式会社 | Imaging system |
| CN101569778A (en) * | 2009-03-10 | 2009-11-04 | 深圳先进技术研究院 | Biofeedback simulation system and biofeedback simulation method |
| CN203677059U (en) * | 2013-11-21 | 2014-07-02 | 中国医学科学院生物医学工程研究所 | Algesia stimulator |
Non-Patent Citations (1)
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