CN102016039B - 异常线粒体dna、相关的融合转录物及其杂交探针 - Google Patents

异常线粒体dna、相关的融合转录物及其杂交探针 Download PDF

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Publication number
CN102016039B
CN102016039B CN200980114773.XA CN200980114773A CN102016039B CN 102016039 B CN102016039 B CN 102016039B CN 200980114773 A CN200980114773 A CN 200980114773A CN 102016039 B CN102016039 B CN 102016039B
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cancer
transcript
seq
mtdna
transcripts
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Chinese (zh)
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CN102016039A (zh
Inventor
瑞安·帕尔
布赖恩·赖古伊
加布里埃尔·达库波
珍妮弗·克里德
凯丽·鲁滨逊
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Dodik Landau Ltd
MDNA LIFE SCIENCES Inc
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Mitomics Inc
MDNA LIFE SCIENCES Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
CN200980114773.XA 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针 Expired - Fee Related CN102016039B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710183734.1A CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4061608P 2008-03-28 2008-03-28
US61/040,616 2008-03-28
PCT/CA2009/000351 WO2009117811A1 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

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CN201710183734.1A Division CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

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CN102016039A CN102016039A (zh) 2011-04-13
CN102016039B true CN102016039B (zh) 2017-06-09

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CN200980114773.XA Expired - Fee Related CN102016039B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN201710183734.1A Active CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN201080014122.6A Expired - Fee Related CN102388140B (zh) 2008-03-28 2010-03-29 异常线粒体dna、相关的融合转录本和翻译产物及其杂交探针

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CN201080014122.6A Expired - Fee Related CN102388140B (zh) 2008-03-28 2010-03-29 异常线粒体dna、相关的融合转录本和翻译产物及其杂交探针

Country Status (10)

Country Link
US (4) US20110172113A1 (enExample)
EP (1) EP2274426B1 (enExample)
JP (1) JP5938690B2 (enExample)
KR (2) KR101819852B1 (enExample)
CN (3) CN102016039B (enExample)
AU (1) AU2009227935B2 (enExample)
CA (2) CA2719718C (enExample)
NZ (2) NZ588658A (enExample)
SG (3) SG192453A1 (enExample)
WO (1) WO2009117811A1 (enExample)

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KR20190136107A (ko) * 2010-03-01 2019-12-09 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 ＵＶ 관련된 ｍｔＤＮＡ 융합 전사체 및 이의 방법 및 용도
AU2011289579B2 (en) 2010-08-10 2016-11-17 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
CA2946064C (en) 2014-02-21 2023-09-26 Ecole Polytechnique Federale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
AU2017280210A1 (en) * 2016-06-22 2019-01-24 Degen Zhuo Method and kit for detecting fusion transcripts
US11978535B2 (en) * 2017-02-01 2024-05-07 The Translational Genomics Research Institute Methods of detecting somatic and germline variants in impure tumors
EP3638296A1 (en) 2017-06-16 2020-04-22 The University Of Chicago Compositions and methods for inducing immune tolerance
JP2021519305A (ja) * 2018-03-26 2021-08-10 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ 肝臓およびリンパ節の類洞内皮細胞Ｃ型レクチン（ＬＳＥＣｔｉｎ）を標的とするための方法および組成物
EP3790577A4 (en) 2018-05-09 2022-04-27 The University of Chicago COMPOSITIONS AND METHODS RELATED TO IMMUNTOLERANCE
KR102992300B1 (ko) * 2018-12-22 2026-07-20 엠디엔에이 라이프 사이언시즈 인코퍼레이티드 자궁내막증과 연관된 미토콘드리아 dna 결실
CN117384269B (zh) * 2023-09-21 2024-06-18 南方医科大学南方医院 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用

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Also Published As

Publication number Publication date
EP2274426B1 (en) 2016-11-16
SG192453A1 (en) 2013-08-30
JP2011515091A (ja) 2011-05-19
JP5938690B2 (ja) 2016-06-22
CA3044262A1 (en) 2009-10-01
CN102388140B (zh) 2015-07-08
CA3044262C (en) 2023-02-28
KR20110004860A (ko) 2011-01-14
CN102388140A (zh) 2012-03-21
US20110172113A1 (en) 2011-07-14
NZ588658A (en) 2012-10-26
AU2009227935B2 (en) 2015-07-09
SG174514A1 (en) 2011-10-28
EP2274426A1 (en) 2011-01-19
WO2009117811A1 (en) 2009-10-01
CA2719718C (en) 2019-07-02
NZ602175A (en) 2014-03-28
CN102016039A (zh) 2011-04-13
CN107011428A (zh) 2017-08-04
AU2009227935A1 (en) 2009-10-01
US20170152567A1 (en) 2017-06-01
SG10201400985RA (en) 2014-05-29
KR20170004033A (ko) 2017-01-10
EP2274426A4 (en) 2011-11-16
KR101693387B1 (ko) 2017-01-05
CA2719718A1 (en) 2009-10-01
KR101819852B1 (ko) 2018-02-28
CN107011428B (zh) 2022-02-25
US8715960B2 (en) 2014-05-06
US20130059299A1 (en) 2013-03-07
US10266899B2 (en) 2019-04-23
US20190382846A1 (en) 2019-12-19

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