CN102016039B - 异常线粒体dna、相关的融合转录物及其杂交探针 - Google Patents

异常线粒体dna、相关的融合转录物及其杂交探针 Download PDF

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Publication number
CN102016039B
CN102016039B CN200980114773.XA CN200980114773A CN102016039B CN 102016039 B CN102016039 B CN 102016039B CN 200980114773 A CN200980114773 A CN 200980114773A CN 102016039 B CN102016039 B CN 102016039B
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cancer
transcript
seq
mtdna
transcripts
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Expired - Fee Related
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CN200980114773.XA
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English (en)
Chinese (zh)
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CN102016039A (zh
Inventor
瑞安·帕尔
布赖恩·赖古伊
加布里埃尔·达库波
珍妮弗·克里德
凯丽·鲁滨逊
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Dodik Landau Ltd
MDNA LIFE SCIENCES Inc
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Mitomics Inc
MDNA LIFE SCIENCES Inc
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Priority to CN201710183734.1A priority Critical patent/CN107011428B/zh
Publication of CN102016039A publication Critical patent/CN102016039A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN200980114773.XA 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针 Expired - Fee Related CN102016039B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710183734.1A CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4061608P 2008-03-28 2008-03-28
US61/040,616 2008-03-28
PCT/CA2009/000351 WO2009117811A1 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Related Child Applications (1)

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CN201710183734.1A Division CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针

Publications (2)

Publication Number Publication Date
CN102016039A CN102016039A (zh) 2011-04-13
CN102016039B true CN102016039B (zh) 2017-06-09

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CN200980114773.XA Expired - Fee Related CN102016039B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN201710183734.1A Active CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN201080014122.6A Expired - Fee Related CN102388140B (zh) 2008-03-28 2010-03-29 异常线粒体dna、相关的融合转录本和翻译产物及其杂交探针

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CN201710183734.1A Active CN107011428B (zh) 2008-03-28 2009-03-27 异常线粒体dna、相关的融合转录物及其杂交探针
CN201080014122.6A Expired - Fee Related CN102388140B (zh) 2008-03-28 2010-03-29 异常线粒体dna、相关的融合转录本和翻译产物及其杂交探针

Country Status (10)

Country Link
US (4) US20110172113A1 (enExample)
EP (1) EP2274426B1 (enExample)
JP (1) JP5938690B2 (enExample)
KR (2) KR101693387B1 (enExample)
CN (3) CN102016039B (enExample)
AU (1) AU2009227935B2 (enExample)
CA (2) CA3044262C (enExample)
NZ (2) NZ602175A (enExample)
SG (3) SG192453A1 (enExample)
WO (1) WO2009117811A1 (enExample)

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EP2274426B1 (en) * 2008-03-28 2016-11-16 MDNA Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
RU2011137486A (ru) * 2009-03-27 2013-05-10 Митомикс Инк. Аберрантная митохондриальная днк, ассоциированные с ней слитые транскрипты, продукты трансляции и гибрадизационные зонды
US20140024025A1 (en) * 2010-03-01 2014-01-23 Andrew Harbottle Uv associated mtdna fusion transcripts and methods and uses thereof
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
AU2011289579B2 (en) 2010-08-10 2016-11-17 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
LT3107563T (lt) 2014-02-21 2021-07-12 Ecole Polytechnique Fédérale De Lausanne (Epfl) Epfl-Tto Gliko-nukreipiantys terapiniai agenai
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
WO2017223194A1 (en) * 2016-06-22 2017-12-28 Degen Zhuo Method and kit for detecting fusion transcripts
WO2018144782A1 (en) * 2017-02-01 2018-08-09 The Translational Genomics Research Institute Methods of detecting somatic and germline variants in impure tumors
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
WO2019191079A1 (en) * 2018-03-26 2019-10-03 The University Of Chicago Methods and compositions for targeting liver and lymph node sinusoidal endothelial cell c-type lectin (lsectin)
EA202092723A1 (ru) 2018-05-09 2021-04-09 Зе Юниверсити Оф Чикаго Композиции и способы, касающиеся иммунной толерантности
EP3899050A2 (en) * 2018-12-22 2021-10-27 MDNA Life Sciences Inc. Mitochondrial dna deletions associated with endometriosis
CN117384269B (zh) * 2023-09-21 2024-06-18 南方医科大学南方医院 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用

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Publication number Publication date
US20130059299A1 (en) 2013-03-07
AU2009227935A1 (en) 2009-10-01
US20170152567A1 (en) 2017-06-01
KR20170004033A (ko) 2017-01-10
CA3044262A1 (en) 2009-10-01
CA3044262C (en) 2023-02-28
CA2719718C (en) 2019-07-02
SG192453A1 (en) 2013-08-30
SG10201400985RA (en) 2014-05-29
US10266899B2 (en) 2019-04-23
EP2274426B1 (en) 2016-11-16
WO2009117811A1 (en) 2009-10-01
CN107011428B (zh) 2022-02-25
NZ588658A (en) 2012-10-26
JP5938690B2 (ja) 2016-06-22
CA2719718A1 (en) 2009-10-01
CN102388140A (zh) 2012-03-21
US20110172113A1 (en) 2011-07-14
CN102388140B (zh) 2015-07-08
KR101693387B1 (ko) 2017-01-05
NZ602175A (en) 2014-03-28
AU2009227935B2 (en) 2015-07-09
JP2011515091A (ja) 2011-05-19
EP2274426A4 (en) 2011-11-16
CN107011428A (zh) 2017-08-04
CN102016039A (zh) 2011-04-13
SG174514A1 (en) 2011-10-28
EP2274426A1 (en) 2011-01-19
KR101819852B1 (ko) 2018-02-28
KR20110004860A (ko) 2011-01-14
US20190382846A1 (en) 2019-12-19
US8715960B2 (en) 2014-05-06

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