AU2009227935B2 - Aberrant mitochondrial DNA, associated fusion transcripts and hybridization probes therefor - Google Patents

Aberrant mitochondrial DNA, associated fusion transcripts and hybridization probes therefor Download PDF

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Publication number
AU2009227935B2
AU2009227935B2 AU2009227935A AU2009227935A AU2009227935B2 AU 2009227935 B2 AU2009227935 B2 AU 2009227935B2 AU 2009227935 A AU2009227935 A AU 2009227935A AU 2009227935 A AU2009227935 A AU 2009227935A AU 2009227935 B2 AU2009227935 B2 AU 2009227935B2
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Australia
Prior art keywords
cancer
transcript
mtdna
mitochondrial
transcripts
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AU2009227935A
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AU2009227935A1 (en
Inventor
Jennifer Creed
Gabriel Dakubo
Ryan Parr
Brian Reguly
Kerry Robinson
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MDNA LIFE SCIENCES Inc
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MDNA LIFE SCIENCES Inc
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Assigned to MDNA LIFE SCIENCES INC. reassignment MDNA LIFE SCIENCES INC. Request for Assignment Assignors: MITOMICS INC.
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6874Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
AU2009227935A 2008-03-28 2009-03-27 Aberrant mitochondrial DNA, associated fusion transcripts and hybridization probes therefor Ceased AU2009227935B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4061608P 2008-03-28 2008-03-28
US61/040,616 2008-03-28
PCT/CA2009/000351 WO2009117811A1 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor

Publications (2)

Publication Number Publication Date
AU2009227935A1 AU2009227935A1 (en) 2009-10-01
AU2009227935B2 true AU2009227935B2 (en) 2015-07-09

Family

ID=41112880

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009227935A Ceased AU2009227935B2 (en) 2008-03-28 2009-03-27 Aberrant mitochondrial DNA, associated fusion transcripts and hybridization probes therefor

Country Status (10)

Country Link
US (4) US20110172113A1 (enExample)
EP (1) EP2274426B1 (enExample)
JP (1) JP5938690B2 (enExample)
KR (2) KR101819852B1 (enExample)
CN (3) CN107011428B (enExample)
AU (1) AU2009227935B2 (enExample)
CA (2) CA3044262C (enExample)
NZ (2) NZ602175A (enExample)
SG (3) SG192453A1 (enExample)
WO (1) WO2009117811A1 (enExample)

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* Cited by examiner, † Cited by third party
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CA3044262C (en) * 2008-03-28 2023-02-28 Mdna Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
AU2010234238B2 (en) * 2009-03-27 2016-07-28 Mdna Life Sciences Inc. Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor
CN102791864B (zh) * 2010-03-01 2015-06-17 米托米克斯公司 Uv相关联的mtrna融合转录体及其方法和用途
AU2011289579B2 (en) 2010-08-10 2016-11-17 Ecole Polytechnique Federale De Lausanne Erythrocyte-binding therapeutics
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
EP3909603A1 (en) 2014-02-21 2021-11-17 Ecole Polytechnique Fédérale de Lausanne (EPFL) Glycotargeting therapeutics
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
WO2017223194A1 (en) * 2016-06-22 2017-12-28 Degen Zhuo Method and kit for detecting fusion transcripts
US11978535B2 (en) * 2017-02-01 2024-05-07 The Translational Genomics Research Institute Methods of detecting somatic and germline variants in impure tumors
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
WO2019191079A1 (en) * 2018-03-26 2019-10-03 The University Of Chicago Methods and compositions for targeting liver and lymph node sinusoidal endothelial cell c-type lectin (lsectin)
JP2021528371A (ja) 2018-05-09 2021-10-21 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 免疫寛容に関する組成物および方法
EP3899050A2 (en) * 2018-12-22 2021-10-27 MDNA Life Sciences Inc. Mitochondrial dna deletions associated with endometriosis
CN117384269B (zh) * 2023-09-21 2024-06-18 南方医科大学南方医院 短肽mfrlp及其在制备动脉重塑相关疾病药物中的应用

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NL154598B (nl) * 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) * 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) * 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US6605433B1 (en) * 1998-08-20 2003-08-12 The Johns Hopkins University Mitochondrial dosimeter
US6203990B1 (en) * 1998-11-06 2001-03-20 Mitokor Method and system for pattern analysis, such as for analyzing oligonucleotide primer extension assay products
US6933120B2 (en) * 2000-06-20 2005-08-23 Michael D. Seidman Method of determining biological/molecular age
US20050026167A1 (en) * 2001-06-11 2005-02-03 Mark Birch-Machin Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
CA2450403A1 (en) * 2001-06-11 2002-12-19 1304854 Ontario Ltd. Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US20030162174A1 (en) * 2001-06-11 2003-08-28 Sutherland John W. Detecting nucleic acid deletion sequences
GB2380194B (en) * 2001-10-01 2005-06-22 Roger Michael Marchbanks A mitochondrial mutation associated with schizophrenia and increased oxidative stress
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CA3044262C (en) 2008-03-28 2023-02-28 Mdna Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
AU2010234238B2 (en) 2009-03-27 2016-07-28 Mdna Life Sciences Inc. Aberrant mitochondrial DNA, associated fusion transcripts and translation products and hybridization probes therefor
CN102791864B (zh) * 2010-03-01 2015-06-17 米托米克斯公司 Uv相关联的mtrna融合转录体及其方法和用途

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Also Published As

Publication number Publication date
KR101819852B1 (ko) 2018-02-28
JP5938690B2 (ja) 2016-06-22
CN102016039A (zh) 2011-04-13
CN102016039B (zh) 2017-06-09
JP2011515091A (ja) 2011-05-19
CN102388140A (zh) 2012-03-21
CN107011428B (zh) 2022-02-25
NZ602175A (en) 2014-03-28
KR20170004033A (ko) 2017-01-10
US10266899B2 (en) 2019-04-23
CA3044262A1 (en) 2009-10-01
EP2274426B1 (en) 2016-11-16
KR101693387B1 (ko) 2017-01-05
CA3044262C (en) 2023-02-28
CA2719718A1 (en) 2009-10-01
CN107011428A (zh) 2017-08-04
US20170152567A1 (en) 2017-06-01
EP2274426A1 (en) 2011-01-19
SG10201400985RA (en) 2014-05-29
US20130059299A1 (en) 2013-03-07
NZ588658A (en) 2012-10-26
EP2274426A4 (en) 2011-11-16
US8715960B2 (en) 2014-05-06
WO2009117811A1 (en) 2009-10-01
SG192453A1 (en) 2013-08-30
US20190382846A1 (en) 2019-12-19
CN102388140B (zh) 2015-07-08
US20110172113A1 (en) 2011-07-14
AU2009227935A1 (en) 2009-10-01
KR20110004860A (ko) 2011-01-14
SG174514A1 (en) 2011-10-28
CA2719718C (en) 2019-07-02

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Owner name: MDNA LIFE SCIENCES INC.

Free format text: FORMER APPLICANT(S): MITOMICS INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired