CN101991638A - Medicine composition for treating facial paralysis as well as preparation method and application thereof - Google Patents

Medicine composition for treating facial paralysis as well as preparation method and application thereof Download PDF

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CN101991638A
CN101991638A CN201010560640XA CN201010560640A CN101991638A CN 101991638 A CN101991638 A CN 101991638A CN 201010560640X A CN201010560640X A CN 201010560640XA CN 201010560640 A CN201010560640 A CN 201010560640A CN 101991638 A CN101991638 A CN 101991638A
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facial paralysis
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hedysari
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CN101991638B (en
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潘畅
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Abstract

The invention relates to a medicine composition for treating facial paralysis as well as a preparation method and application thereof, belonging to the field of medicines. The medicine composition is prepared from the following raw materials in weight ratio: 5-7 parts of Chinese angelica, 5-7 parts of milkvetch roots or 3-7 parts of rhodiolae roots, 1-2 parts of scorpion, 2-4 parts of earthworm, 1-3 parts of centipede, 2-4 parts of stiff silkworm and 2-4 parts of cicada slough. The medicine composition for treating facial paralysis has obvious effect and can improve the syndromes of unfree cheek movement, side inclination, mouth corner ptosis and incapability of raising eyebrows, frowning, closing the eyes, blasting air, pouting and the like caused by completed paralyzed facial pathetic muscle.

Description

A kind of pharmaceutical composition for the treatment of facial paralysis and its production and use
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of pharmaceutical composition for the treatment of facial paralysis and its production and use.
Background technology
Facial paralysis, the non-specific facial paralysis of formal name used at school (or claiming peripheral facial paralysis), be commonly called as "
Figure BDA0000034454070000011
Face ", " facial paralysis " etc., be to be a kind of commonly encountered diseases of principal character with facial expression muscle group dyskinesia, general symptom is a mouthful eye
Figure BDA0000034454070000012
Tiltedly.Patient's face is often the most basic lifts eyebrow, close one's eyes, the drum cheek, action such as pout one's lips as a signal all can't be finished.
The existing facial paralysis that studies show that is because of due to the peripheral nerve injury, common treatment means has acupuncture, paste medicine, cup, cut control, fiery pin, acusector, physical therapy, nasal obstruction medicine, interventional therapy, facial injectable drug etc. and some local methods among the people (as wiping Sanguis Monopteri albi) etc.Can be used for treating facial paralysis as QIANZHENGSAN, facial paralysis health in the street drug.
Based on above-mentioned present situation, the invention human desires provides a kind of brand-new medicine to be used for the treatment of or improves to paralyse fully because of facial expression muscle and causes ineffective, the Ipsilateral of buccal action
Figure BDA0000034454070000013
Tiltedly, ptosis of labial angle, sick side can not be made the wrinkle volume, be frowned, close order, air-blowing and the symptom of action such as be in a pout.
Summary of the invention
Technical problem solved by the invention provides a kind of brand-new medicinal composition and is used for the treatment of facial paralysis.
Pharmaceutical composition of the present invention is the medicament that is prepared from by following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part or Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.The Radix Astragali and Radix Hedysari can exchange in the pharmaceutical composition of the present invention, and consumption is slightly different, and pharmaceutical composition of the present invention can adopt following two schemes:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part; Or
Radix Angelicae Sinensis 5-7 part, Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.
Further preferred: 7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali or 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes.Be that pharmaceutical composition of the present invention can adopt following two technical schemes:
7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes; Or
7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes.
Take pharmaceutical composition of the present invention and can obviously improve ineffective, the Ipsilateral of buccal action due to the facial paralysis
Figure BDA0000034454070000014
Tiltedly, ptosis of labial angle, can not make the wrinkle volume, frown, close order, air-blowing and the symptom of action such as be in a pout.
Sum up through prolonged application, the present invention also provides a kind of pharmaceutical composition for the treatment of the facial paralysis more remarkable treatment effect, be to have added Radix Platycodonis, Rhizoma Chuanxiong, Radix Rhodiolae, Radix Ginseng (or Radix Ginseng Rubra) on the basis of aforementioned pharmaceutical composition, preferred pharmaceutical composition is the medicament that is prepared from by following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part (or Radix Hedysari 3-5 part), Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part, Radix Rehmanniae 3-5 part (or Radix Rehmanniae Preparata 1-3 part), Radix Platycodonis 1-2 part, Rhizoma Chuanxiong 2-4 part, Radix Rhodiolae 5-7 part, Radix Ginseng 1-3 part (or Radix Ginseng Rubra 5-7 part).The Radix Astragali is close with the Radix Hedysari effect in this pharmaceutical composition, and the Radix Rehmanniae is close with the Radix Rehmanniae Preparata effect, and the people participates in that the Radix Ginseng Rubra effect is close, and the two is interchangeable, but finds in using that Radix Hedysari invigorating the spleen and replenishing QI effect is better than the Radix Astragali; The Radix Rehmanniae Preparata blood tonification effect is better than the Radix Rehmanniae, but grows greasy imapirment of the spleen and stomach, and Radix Rehmanniae removing heat from blood is enriched blood, and is difficult for damaging the spleen and stomach, multiselect Radix Rehmanniae during clinical practice; Radix Ginseng Rubra is the cultivation product of Radix Ginseng, and QI invigorating is gentle than Radix Ginseng, so the normal Radix Ginseng Rubra that adopts.
One step is preferred, 2 parts of 3 parts in 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, the Radix Rehmanniae (or Radix Rehmanniae Preparata 1 part), 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, Radix Ginsengs (or Radix Ginseng Rubra 5 parts).
Pharmaceutical composition of the present invention is to adopt the above-mentioned raw materials medicine, adds the medicament that acceptable accessories is prepared from according to conventional method; Mainly based on oral formulations.At the application characteristic of medicine of the present invention, also provide this preparation of drug combination method.
Method one: each crude drug is ground into fine powder, mix powder.
Method two: each crude drug is ground into fine powder, makes pill according to a conventional method.
Method three: each crude drug is ground into fine powder, is pressed into tablet according to a conventional method.
Method four: each crude drug is ground into fine powder, makes capsule according to a conventional method.Encapsulated as fine powder being mixed the back, or fine powder granulation back is encapsulated.
Method five: with each raw material routinely the decocting mode boil.
Use said method and all can realize improving the purpose of facial paralysis symptom, but easy in response to the convenience of usefulness and preparation, the inventor is made into capsule more and uses.
Pharmaceutical composition of the present invention also can be used for treating facial paralysis (being called central facial palsy again) after the cerebrovascular accident, and its symptom mainly shows as the Ipsilateral face
Figure BDA0000034454070000021
Tiltedly, ptosis of labial angle, action such as can not do air-blowing and be in a pout, but the volume that can wrinkle, frown, close order.
To sum up, use pharmaceutical composition provided by the invention and all can improve or treat peripheral facial paralysis facial paralysis and central facial palsy, especially cause ineffective, the face of buccal action at paralysing fully because of facial expression muscle
Figure BDA0000034454070000022
Tiltedly, ptosis of labial angle, sick side can not make the wrinkle volume, frown, close order, air-blowing and the symptom of action such as be in a pout has clear and definite therapeutic effect, stable curative effect, controlled.
The specific embodiment
Below by specific description of embodiments of the present invention the explanation but do not limit the present invention.
Pharmaceutical composition of the present invention is to be prepared from by following materials of weight proportions medicine: Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part (or Radix Hedysari 3-5 part), Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.Crude drug floats in this amount ranges all can realize improving the purpose of facial paralysis symptom.
Find that through inventor's long-term practice 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of effects of Periostracum Cicadae are clearer and more definite, more stable.
Further preferred, in order to strengthen, stablize curative effect, crude drug also contains Radix Platycodonis, Rhizoma Chuanxiong, Radix Rhodiolae, Radix Ginseng, and the crude drug weight proportion is as follows:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part (or Radix Hedysari 3-5 part), Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part, Radix Rehmanniae 3-5 part (or Radix Rehmanniae Preparata 1-3 part), Radix Platycodonis 1-2 part, Rhizoma Chuanxiong 2-4 part, Radix Rhodiolae 5-7 part, Radix Ginseng 1-3 part (or Radix Ginseng Rubra 5-7 part).
Further preferred, pharmaceutical composition of the present invention adopts following materials of weight proportions medicine, and its curative effect is clearer and more definite, more stable: 2 parts of 3 parts in 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, the Radix Rehmanniae (or Radix Rehmanniae Preparata 1 part), 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, Radix Ginsengs (or Radix Ginseng Rubra 5 parts).
The Radix Astragali described in the above-mentioned raw materials medicine adopts Radix Astragali Preparata; Described Radix Hedysari adopts Radix Hedysari Preparata; Radix Ginseng can also adopt Radix Ginseng Rubra to replace: Radix Ginseng Rubra is the cultivation product of Radix Ginseng, and QI invigorating is gentle than Radix Ginseng, so the normal Radix Ginseng Rubra that adopts.
For the ease of using, can on the basis of crude drug, add acceptable accessories and make oral formulations commonly used.As powder, pill, tablet, capsule, water decoction.
Pharmaceutical composition of the present invention causes ineffective, the Ipsilateral of buccal action at paralysing fully because of facial expression muscle
Figure BDA0000034454070000031
Tiltedly, ptosis of labial angle, can not make the wrinkle volume, frown, close order, air-blowing and the doing well,improving effect of action such as be in a pout remarkable, stable curative effect, controlled.Therapeutic effect at apoplectic hemiplegia is also more obvious.
Below beneficial effect by clinical statistics proof pharmaceutical composition of the present invention.
It is clinical that the inventor adopts pharmaceutical composition of the present invention to be applied to, and specifically is to be made into capsule to use, and preparation method is as follows:
1, capsule A: get following materials of weight proportions medicine: 7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, pulverize the back and mix encapsulated.Every capsules contains crude drug 0.4g.
2, capsule B: get following materials of weight proportions medicine: 7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, 3 parts in the Radix Rehmanniae, 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, 5 parts of Radix Ginseng Rubra, pulverize the back and mix encapsulated.Every capsules contains crude drug 0.4g.
Control drug: commercially available QIANZHENGSAN and DAHUOLUO WAN.
Oral powder pharmaceutical composition of the present invention and control drug, medicine adult taking dose of the present invention is each 1.2g, and three times on the one, be 15 days the course of treatment, and the therapeutic effect statistical data sees Table 1-2:
Table 1
Figure BDA0000034454070000041
Table 2
Figure BDA0000034454070000042
Pharmaceutical composition of the present invention is year clinical observation surplus ten, determines with Radix Angelicae Sinensis, the Radix Astragali or Radix Hedysari, Scorpio, Pheretima, Scolopendra, Bombyx Batryticatus, Periostracum Cicadae, the Radix Rehmanniae, Radix Platycodonis, Rhizoma Chuanxiong, Radix Rhodiolae, Radix Ginseng at last behind the screening prescription.Be crude drug, therapeutic effect the best, and determine that its proportion relation is: 2 parts of 3 parts in 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, the Radix Rehmanniae (or Radix Rehmanniae Preparata 1 part), 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, Radix Ginsengs (or Radix Ginseng Rubra 5 parts) therapeutic effect is clear and definite, stable curative effect.Radix Hedysari invigorating the spleen and replenishing QI effect is better than the Radix Astragali in the application; The Radix Rehmanniae Preparata blood tonification effect is better than the Radix Rehmanniae, but grows greasy imapirment of the spleen and stomach, and Radix Rehmanniae removing heat from blood is enriched blood, and is difficult for damaging the spleen and stomach, multiselect Radix Rehmanniae during clinical practice; Radix Ginseng Rubra is the cultivation product of Radix Ginseng, and QI invigorating is gentle than Radix Ginseng, so the normal Radix Ginseng Rubra that adopts.So maximum prescriptions is used in inventor Linchuan: 7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, 3 parts in the Radix Rehmanniae, 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, 5 parts of Radix Ginseng Rubra.
Specify:
Description indication of the present invention " facial paralysis " refers to non-specific facial paralysis, i.e. peripheral facial paralysis.

Claims (8)

1. pharmaceutical composition for the treatment of facial paralysis, it is characterized in that: it is the medicament that is prepared from by following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part or Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.
2. the pharmaceutical composition of treatment facial paralysis according to claim 1 is characterized in that: it is the medicament that is prepared from by following materials of weight proportions medicine:
7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali or 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes.
3. pharmaceutical composition for the treatment of facial paralysis, it is characterized in that: it is the medicament that is prepared from by following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part or Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part, Radix Rehmanniae 3-5 part or Radix Rehmanniae Preparata 1-3 part, Radix Platycodonis 1-2 part, Rhizoma Chuanxiong 2-4 part, Radix Rhodiolae 5-7 part, Radix Ginseng 1-3 part or Radix Ginseng Rubra 5-7 part.
4. the pharmaceutical composition of treatment facial paralysis according to claim 3 is characterized in that: it is the medicament that is prepared from by following materials of weight proportions medicine:
5 parts of 7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali or 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, 3 parts in the Radix Rehmanniae or 1 part in Radix Rehmanniae Preparata, 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, 2 parts of Radix Ginsengs or Radix Ginseng Rubra.
5. according to the pharmaceutical composition of each described treatment facial paralysis of claim 1-4, it is characterized in that: the described Radix Astragali adopts Radix Astragali Preparata; Described Radix Hedysari adopts Radix Hedysari Preparata.
6. the preparation of drug combination method of each described treatment facial paralysis of claim 1-4 is characterized in that: adopt the following steps preparation:
A, each crude drug is ground into fine powder, mixes getting final product; Or
B, fine powder is made pill according to a conventional method; Or
Fine powder is pressed into tablet according to a conventional method with fine powder; Or
Make capsule according to a conventional method.
7. the preparation of drug combination method of each described treatment facial paralysis of claim 1-4 is characterized in that: adopt the following steps preparation: each crude drug is mixed adopt the mode of conventional decocting herb to obtain decocting liquid.
8. right is wanted the purposes of each described pharmaceutical composition of 1-4 in the medicine of preparation treatment central facial palsy.
CN201010560640XA 2010-11-26 2010-11-26 Medicine composition for treating facial paralysis as well as preparation method and application thereof Expired - Fee Related CN101991638B (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102416036A (en) * 2011-12-09 2012-04-18 上海市中医医院 Chinese medicinal compositions for preventing and treating ventricular reconstruction due to coronary heart disease and use thereof
CN104107204A (en) * 2014-08-08 2014-10-22 何德亮 Medicinal composition for treating encephalatrophy and facial paralysis
CN105287724A (en) * 2014-06-15 2016-02-03 张红伶 Medicine for treating facioplegia
CN106389727A (en) * 2016-11-11 2017-02-15 东莞市百替生物科技有限公司 Traditional Chinese medicine preparation for treating facial paralysis and preparing method thereof
CN107550974A (en) * 2017-10-30 2018-01-09 潘畅 Externally-applied medicinal composition of facial paralysis and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101607050A (en) * 2009-07-22 2009-12-23 唐浩 A kind of medicine for the treatment of facial paralysis

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN101607050A (en) * 2009-07-22 2009-12-23 唐浩 A kind of medicine for the treatment of facial paralysis

Non-Patent Citations (2)

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Title
《中医药研究》 20001031 李洪志等 自拟双龙五虫汤结合针灸治疗面肌痉挛症 34-35 1-2、5-7 第16卷, 第5期 2 *
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102416036A (en) * 2011-12-09 2012-04-18 上海市中医医院 Chinese medicinal compositions for preventing and treating ventricular reconstruction due to coronary heart disease and use thereof
CN102416036B (en) * 2011-12-09 2014-05-07 上海市中医医院 Traditional Chinese medicinal compositions for preventing and treating ventricular reconstruction due to coronary heart disease and use thereof
CN105287724A (en) * 2014-06-15 2016-02-03 张红伶 Medicine for treating facioplegia
CN104107204A (en) * 2014-08-08 2014-10-22 何德亮 Medicinal composition for treating encephalatrophy and facial paralysis
CN106389727A (en) * 2016-11-11 2017-02-15 东莞市百替生物科技有限公司 Traditional Chinese medicine preparation for treating facial paralysis and preparing method thereof
CN107550974A (en) * 2017-10-30 2018-01-09 潘畅 Externally-applied medicinal composition of facial paralysis and application thereof

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