CN101991638B - Medicine composition for treating facial paralysis as well as preparation method and application thereof - Google Patents
Medicine composition for treating facial paralysis as well as preparation method and application thereof Download PDFInfo
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- CN101991638B CN101991638B CN201010560640XA CN201010560640A CN101991638B CN 101991638 B CN101991638 B CN 101991638B CN 201010560640X A CN201010560640X A CN 201010560640XA CN 201010560640 A CN201010560640 A CN 201010560640A CN 101991638 B CN101991638 B CN 101991638B
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Abstract
The invention relates to a medicine composition for treating facial paralysis as well as a preparation method and application thereof, belonging to the field of medicines. The medicine composition is prepared from the following raw materials in weight ratio: 5-7 parts of Chinese angelica, 5-7 parts of milkvetch roots or 3-7 parts of rhodiolae roots, 1-2 parts of scorpion, 2-4 parts of earthworm, 1-3 parts of centipede, 2-4 parts of stiff silkworm and 2-4 parts of cicada slough. The medicine composition for treating facial paralysis has obvious effect and can improve the syndromes of unfree cheek movement, side inclination, mouth corner ptosis and incapability of raising eyebrows, frowning, closing the eyes, blasting air, pouting and the like caused by completed paralyzed facial pathetic muscle.
Description
Technical field
The invention belongs to field of medicaments, be specifically related to a kind of pharmaceutical composition of treating facial paralysis.
Background technology
Facial paralysis; The non-specific facial paralysis of formal name used at school (or claiming peripheral facial paralysis); Be commonly called as "
face ", " facial paralysis " etc.; Be to be a kind of commonly encountered diseases of principal character with facial expression muscle group dyskinesia, general symptom is that mouthful eye
is oblique.Patient's face is often the most basic lifts eyebrow, close one's eyes, the drum cheek, action such as pout one's lips as a signal all can't be accomplished.
Existing research shows that facial paralysis is because of due to the peripheral nerve injury, common treatment means has acupuncture, paste medicine, cup, cut control, fiery pin, acusector, physical therapy, nasal obstruction medicine, interventional therapy, facial injectable drug etc. and some local methods among the people (as wiping Sanguis Monopteri albi) etc.Can be used for treating facial paralysis like QIANZHENGSAN, facial paralysis health in the street drug.
Based on above-mentioned present situation, the invention human desires provide a kind of brand-new medicine to be used for treatment or improve paralyse fully because of facial expression muscle cause that the buccal action is ineffective, Ipsilateral
tiltedly, ptosis of labial angle, sick side can not make the wrinkle volume, frown, close order, air-blowing and the symptom of action such as be in a pout.
Summary of the invention
The technical problem that the present invention solved provides a kind of brand-new medicinal composition and is used to treat facial paralysis.
Pharmaceutical composition of the present invention is the medicament that is prepared from following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part or Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.The Radix Astragali and Radix Hedysari can exchange in the pharmaceutical composition of the present invention, and consumption is slightly different, and pharmaceutical composition of the present invention can adopt following two schemes:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part; Or
Radix Angelicae Sinensis 5-7 part, Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.
Further preferred: 7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali or 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes.Be that pharmaceutical composition of the present invention can adopt following two technical schemes:
7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes; Or
7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes.
Take that pharmaceutical composition of the present invention can improve obviously that buccal action due to the facial paralysis is ineffective, Ipsilateral
tiltedly, ptosis of labial angle, can not make the wrinkle volume, frown, close order, air-blowing and the symptom of action such as be in a pout.
Sum up through prolonged application; The present invention also provides a kind of pharmaceutical composition of treating the facial paralysis more remarkable treatment effect; Be on the basis of aforementioned pharmaceutical composition, to have added Radix Platycodonis, Rhizoma Chuanxiong, Radix Rhodiolae, Radix Ginseng (or Radix Ginseng Rubra), preferred pharmaceutical composition is the medicament that is prepared from following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part (or Radix Hedysari 3-5 part), Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part, Radix Rehmanniae 3-5 part (or Radix Rehmanniae Preparata 1-3 part), Radix Platycodonis 1-2 part, Rhizoma Chuanxiong 2-4 part, Radix Rhodiolae 5-7 part, Radix Ginseng 1-3 part (or Radix Ginseng Rubra 5-7 part).The Radix Astragali is close with the Radix Hedysari effect in this pharmaceutical composition, and the Radix Rehmanniae is close with the Radix Rehmanniae Preparata effect, and the people participates in that the Radix Ginseng Rubra effect is close, and the two is interchangeable, but finds in using that Radix Hedysari invigorating the spleen and replenishing QI effect is superior to the Radix Astragali; The Radix Rehmanniae Preparata blood tonification effect is better than the Radix Rehmanniae, but grows greasy imapirment of the spleen and stomach, and Radix Rehmanniae removing heat from blood is enriched blood, and is difficult for damaging the spleen and stomach, and multiselect is used the Radix Rehmanniae during clinical practice; Radix Ginseng Rubra is the cultivation article of Radix Ginseng, and QI invigorating is gentle than Radix Ginseng, so the normal Radix Ginseng Rubra that adopts.
One step is preferred, 2 parts of 3 parts in 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, the Radix Rehmanniae (or Radix Rehmanniae Preparata 1 part), 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, Radix Ginsengs (or Radix Ginseng Rubra 5 parts).
Pharmaceutical composition of the present invention is to adopt the above-mentioned raw materials medicine, adds the medicament that acceptable accessories is prepared from according to conventional method; Be main mainly with oral formulations.To the application characteristic of medicine of the present invention, this preparation of drug combination method is provided also.
Method one: each crude drug is ground into fine powder, mix powder.
Method two: each crude drug is ground into fine powder, processes pill by conventional method.
Method three: each crude drug is ground into fine powder, is pressed into tablet by conventional method.
Method four: each crude drug is ground into fine powder, processes capsule by conventional method.Encapsulated as fine powder being mixed the back, or fine powder granulation back is encapsulated.
Method five: each raw material is boiled by conventional decocting mode.
Use said method and all can realize improving the purpose of facial paralysis symptom, but easy in response to the convenience of usefulness and preparation, the inventor is made into the capsule application more.
Pharmaceutical composition of the present invention also can be used for treating facial paralysis (being called central facial palsy again) after the cerebrovascular accident; Its symptom mainly show as Ipsilateral face
tiltedly, ptosis of labial angle; Action such as can not do air-blowing and be in a pout, but the volume that can wrinkle, frown, close order.
To sum up; Use pharmaceutical composition provided by the invention and all can improve or treat peripheral facial paralysis facial paralysis and central facial palsy; Especially cause to paralysing fully that buccal action is ineffective because of facial expression muscle, face
tiltedly, ptosis of labial angle, sick side can not make the wrinkle volume, frown, close order, air-blowing and the symptom of action such as be in a pout has clear and definite therapeutic effect; Stable curative effect, controlled.
The specific embodiment
Below through to the description of specific embodiment of the invention explanation but do not limit the present invention.
Pharmaceutical composition of the present invention is to be prepared from following materials of weight proportions medicine: Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part (or Radix Hedysari 3-5 part), Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.Crude drug floats in this amount ranges all can realize improving the purpose of facial paralysis symptom.
Find through inventor's long-term practice, 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of effects of Periostracum Cicadae more clearly, more stable.
Further preferred, in order to strengthen, stablize curative effect, crude drug also contains Radix Platycodonis, Rhizoma Chuanxiong, Radix Rhodiolae, Radix Ginseng, and the crude drug weight proportion is following:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part (or Radix Hedysari 3-5 part), Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part, Radix Rehmanniae 3-5 part (or Radix Rehmanniae Preparata 1-3 part), Radix Platycodonis 1-2 part, Rhizoma Chuanxiong 2-4 part, Radix Rhodiolae 5-7 part, Radix Ginseng 1-3 part (or Radix Ginseng Rubra 5-7 part).
Further preferred; Pharmaceutical composition of the present invention adopts following materials of weight proportions medicine, its curative effect more clearly, more stable: 2 parts of 3 parts in 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, the Radix Rehmanniae (or Radix Rehmanniae Preparata 1 part), 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, Radix Ginsengs (or Radix Ginseng Rubra 5 parts).
The Radix Astragali described in the above-mentioned raw materials medicine adopts Radix Astragali Preparata; Described Radix Hedysari adopts Radix Hedysari Preparata; Radix Ginseng can also adopt the Radix Ginseng Rubra replacement: Radix Ginseng Rubra is the cultivation article of Radix Ginseng, and QI invigorating is gentle than Radix Ginseng, so the normal Radix Ginseng Rubra that adopts.
For the ease of using, can on the basis of crude drug, add acceptable accessories and process oral formulations commonly used.Like powder, pill, tablet, capsule, water decoction.
Pharmaceutical composition of the present invention causes to paralysing fully because of facial expression muscle that buccal action is ineffective, Ipsilateral
tiltedly, ptosis of labial angle, can not make the wrinkle volume, frown, close order, air-blowing and the doing well,improving effect of action such as be in a pout remarkable; Stable curative effect, controlled.Therapeutic effect to apoplectic hemiplegia is also more obvious.
Below prove the beneficial effect of pharmaceutical composition of the present invention through clinical statistics.
It is clinical that the inventor adopts pharmaceutical composition of the present invention to be applied to, and specifically is to be made into capsule to use, and method for preparing is following:
1, capsule A: get following materials of weight proportions medicine: 7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, pulverize the back and mix encapsulated.Every capsules contains crude drug 0.4g.
2, capsule B: get following materials of weight proportions medicine: 7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, 3 parts in the Radix Rehmanniae, 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, 5 parts of Radix Ginseng Rubra, pulverize the back and mix encapsulated.Every capsules contains crude drug 0.4g.
Control drug: commercially available QIANZHENGSAN and DAHUOLUO WAN.
Oral powder pharmaceutical composition of the present invention and control drug, medicine adult taking dose of the present invention is each 1.2g, and three times on the one, be 15 days the course of treatment, and the therapeutic effect statistical data is seen table 1-2:
Table 1
Table 2
Pharmaceutical composition of the present invention is year clinical observation surplus ten, confirms with Radix Angelicae Sinensis, the Radix Astragali or Radix Hedysari, Scorpio, Pheretima, Scolopendra, Bombyx Batryticatus, Periostracum Cicadae, the Radix Rehmanniae, Radix Platycodonis, Rhizoma Chuanxiong, Radix Rhodiolae, Radix Ginseng at last behind the screening prescription.Be crude drug; Therapeutic effect is best; And confirm that its proportion relation is: 2 parts of 3 parts in 5 parts of 7 parts of Radix Angelicae Sinensis, the Radix Astragali (or Radix Hedysari 3 parts), 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, the Radix Rehmanniae (or Radix Rehmanniae Preparata 1 part), 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, Radix Ginsengs (or Radix Ginseng Rubra 5 parts) therapeutic effect is clear and definite, stable curative effect.Radix Hedysari invigorating the spleen and replenishing QI effect is superior to the Radix Astragali in the application; The Radix Rehmanniae Preparata blood tonification effect is better than the Radix Rehmanniae, but grows greasy imapirment of the spleen and stomach, and Radix Rehmanniae removing heat from blood is enriched blood, and is difficult for damaging the spleen and stomach, and multiselect is used the Radix Rehmanniae during clinical practice; Radix Ginseng Rubra is the cultivation article of Radix Ginseng, and QI invigorating is gentle than Radix Ginseng, so the normal Radix Ginseng Rubra that adopts.So maximum prescriptions is used in inventor Linchuan: 7 parts of Radix Angelicae Sinensis, 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, 3 parts in the Radix Rehmanniae, 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, 5 parts of Radix Ginseng Rubra.
Specify:
Description indication of the present invention " facial paralysis " refers to non-specific facial paralysis, i.e. peripheral facial paralysis.
Claims (8)
1. pharmaceutical composition of treating facial paralysis, it is characterized in that: it is the medicament that is prepared from following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part or Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part.
2. the pharmaceutical composition of treatment facial paralysis according to claim 1 is characterized in that: it is the medicament that is prepared from following materials of weight proportions medicine:
7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali or 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes.
3. pharmaceutical composition of treating facial paralysis, it is characterized in that: it is the medicament that is prepared from following materials of weight proportions medicine:
Radix Angelicae Sinensis 5-7 part, Radix Astragali 5-7 part or Radix Hedysari 3-5 part, Scorpio 1-3 part, Pheretima 2-4 part, Scolopendra 1-3 part, Bombyx Batryticatus 2-4 part, Periostracum Cicadae 2-4 part, Radix Rehmanniae 3-5 part or Radix Rehmanniae Preparata 1-3 part, Radix Platycodonis 1-2 part, Rhizoma Chuanxiong 2-4 part, Radix Rhodiolae 5-7 part, Radix Ginseng 1-3 part or Radix Ginseng Rubra 5-7 part.
4. the pharmaceutical composition of treatment facial paralysis according to claim 3 is characterized in that: it is the medicament that is prepared from following materials of weight proportions medicine:
5 parts of 7 parts of Radix Angelicae Sinensis, 5 parts of the Radixs Astragali or 3 parts of Radix Hedysari, 2 parts of Scorpios, 4 parts of Pheretimas, 1 part of Scolopendra, 3 parts of Bombyx Batryticatus, 3 parts of Periostracum Cicadaes, 3 parts in the Radix Rehmanniae or 1 part in Radix Rehmanniae Preparata, 1 part of Radix Platycodonis, 2 parts of Rhizoma Chuanxiongs, 5 parts of Radix Rhodiolaes, 2 parts of Radix Ginsengs or Radix Ginseng Rubra.
5. according to the pharmaceutical composition of each described treatment facial paralysis of claim 1-4, it is characterized in that: the described Radix Astragali adopts Radix Astragali Preparata; Described Radix Hedysari adopts Radix Hedysari Preparata.
6. the preparation of drug combination method of each described treatment facial paralysis of claim 1-4 is characterized in that: adopt the following steps preparation:
Each crude drug is ground into fine powder, mixes getting final product; Or
Each crude drug is ground into fine powder, fine powder is processed pill by conventional method; Or
Each crude drug is ground into fine powder, fine powder is pressed into tablet by conventional method; Or
Each crude drug is ground into fine powder, fine powder is processed capsule by conventional method.
7. the preparation of drug combination method of each described treatment facial paralysis of claim 1-4 is characterized in that: adopt the following steps preparation: each crude drug is mixed adopt the mode of conventional decocting herb to obtain decocting liquid.
8. the purposes of each described pharmaceutical composition of claim 1-4 in the medicine of preparation treatment central facial palsy.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102416036B (en) * | 2011-12-09 | 2014-05-07 | 上海市中医医院 | Traditional Chinese medicinal compositions for preventing and treating ventricular reconstruction due to coronary heart disease and use thereof |
| CN105287724A (en) * | 2014-06-15 | 2016-02-03 | 张红伶 | Medicine for treating facioplegia |
| CN104107204A (en) * | 2014-08-08 | 2014-10-22 | 何德亮 | Medicinal composition for treating encephalatrophy and facial paralysis |
| CN106389727A (en) * | 2016-11-11 | 2017-02-15 | 东莞市百替生物科技有限公司 | Traditional Chinese medicine preparation for treating facial paralysis and preparing method thereof |
| CN107550974A (en) * | 2017-10-30 | 2018-01-09 | 潘畅 | Externally-applied medicinal composition of facial paralysis and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101607050A (en) * | 2009-07-22 | 2009-12-23 | 唐浩 | A kind of medicine for the treatment of facial paralysis |
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| CN101607050A (en) * | 2009-07-22 | 2009-12-23 | 唐浩 | A kind of medicine for the treatment of facial paralysis |
Non-Patent Citations (2)
| Title |
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| 李洪志等.自拟双龙五虫汤结合针灸治疗面肌痉挛症.《中医药研究》.2000,第16卷(第5期),34-35. * |
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