CN101979039A - Medicine for treating mental disease - Google Patents
Medicine for treating mental disease Download PDFInfo
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- CN101979039A CN101979039A CN2010105257451A CN201010525745A CN101979039A CN 101979039 A CN101979039 A CN 101979039A CN 2010105257451 A CN2010105257451 A CN 2010105257451A CN 201010525745 A CN201010525745 A CN 201010525745A CN 101979039 A CN101979039 A CN 101979039A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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Abstract
The invention discloses a medicine for treating mental disease. Gentian, aloe, Chinese angelica, goldthread, golden cypress, scutellaria root, cape jasmine fruit, rheum officinale, costustoot, indigo naturalis, musk and chordiazepoxide are mixed uniformly, and crushed into 200-mesh fine powder, and the fine powder is filled into capsules to prepare a capsule preparation. The medicine has the effects of clearing heat and releasing toxin, cooling liver and arresting convulsion, relaxing bowel, and causing resuscitation and restoring consciousness, and is mainly used for treating mania, namely dementia praecox. The medicine has the quick and effective effect of antipsychotic western medicines, also achieves the curing effect of traditional Chinese medicines, does not need to be taken for a long time after the mental disease is cured, reduces harmful side effects on heart, liver, spleen, lung and kidney due to long-term administration of western medicines, and radically solves the problems of mental pressure of psychopaths and troubles for long-term administration of the antipsychotic western medicines. Through clinical curative effect observation, the total effective rate is 88.0 percent.
Description
Technical field
The present invention relates to a kind of psychotolytic medicine, particularly relating to a kind of is the antipsychotic medicine of crude drug preparation with Chinese medicine.
Background technology
Mental sickness is meant that under the influence of inside and outside various paathogenic factors, the cerebral function activity gets muddled, and causes being familiar with, ergasia such as emotion, behavior and will disease of obstacle in various degree.Because the characteristics and the complexity of mental sickness itself, the etiological study that the world medicine bound pair should disease is failed to understand so far at present.Because etiology unknown can't be put in poison at the cause of disease, can only adopt traditional psychosis Western medicine symptomatic treatment.
The psychosis Western medicine is a kind of effective treatment way through clinical treatment observation, can both reach control and improves most of mental patient's mental symptom.But its weak point is to need the normal phase to take medicine to keep, in case drug withdrawal, psychosis just may recur once more.The psychotic takes medicine all the life, again and again hospitalization can bring lifelong misery and stress to the patient.
Mental sickness belongs to the traditional Chinese medical science " depressed, demented " category, the Chinese medicine mental sickness, both having brought into play the psychosis Western medicine acts on fast and effectively, at the theory of Chinese medical science of mad disease, use the principle of Chinese medicine heat clearing away and internal heat reducing, again finally to reach the purpose of healing, do not need the consolidation of taking medicine for a long time after the healing, reduced Western medicine and taken for a long time, caused the murder by poisoning side effect of Western medicine, thoroughly solved the trouble and worry of psychotic's stress and long-term clothes psychosis Western medicine the heart, liver, spleen, lung, kidney.Therefore, the Chinese medicine preparation of exploitation determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs has the important clinical meaning for the treatment of mental sickness.
Summary of the invention
The purpose of this invention is to provide a kind of psychotic medicine that is used for the treatment of, to eliminate the dependency of psychotic to the psychosis Western medicine.
Medicine of the present invention is that the component by following parts by weight is that crude drug prepares:
Radix Gentianae 30～60 Aloes 30～50
Radix Angelicae Sinensis 30～40 Rhizoma Coptidis 10～30
Cortex Phellodendri 10～30 Radix Scutellariaes 20～30
HEIZHIZI 10～20 Radix Et Rhizoma Rhei 10～20
The Radix Aucklandiae 30～40 Indigo Naturaliss 30～40
Moschus 10～15 clozapines 10～15.
Said medicine can be made any conventional peroral dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each crude drug being made medicine of the present invention is:
Get Radix Gentianae, Aloe, Radix Angelicae Sinensis, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, HEIZHIZI, Radix Et Rhizoma Rhei, the Radix Aucklandiae, Indigo Naturalis, Moschus, the clozapine mix homogeneously of described parts by weight, be ground into 200 purpose fine powders, in incapsulating, make capsule of the present invention.
Usage: the adult takes 2, every day 2 times, oral meal at every turn.Be mainly used in the mad disease of treatment, just Western medicine diagnose is a schizophrenia, mania and so on, and other type is not in the therapeutic domain of medicine of the present invention.
About normal ergasia, " interior warp " belongs to the function of the mind to people's ergasia, so-called " heart storing spirit " " heart person occupies master's official, and here gods go out "." mind " be host's ergasia not only, and the people's under the overall leadership vital organs of the human body, thus " heart person ", the big master of the vital organs of the human body also, spirit give up also." a Ling Shu Miraculous Pivot or Divine Axis Benshen piece of writing " pointed out, the substances of producing primal life activities being essence, and two essences are the god of rich meaning mutually, and the people begins to give birth to, and XianCheng's essence, essence become brains life then.God person, essence-QI from water and grain also.Fixed as ten years old the five internal organs of " a Ling Shu Miraculous Pivot or Divine Axis natural life-span piece of writing " life beginning, vim and vigour are logical, and life is at the age of one hundred years old, and the five internal organs are all empty, and manner is all gone, the solitary and conclusion at whole refreshing conformal end of human skeleton.This shows that the argumentation of motherland's medical science ergasia has had materialistic viewpoint.Refreshing activity show with " five god " and " five will " in " interior warp ", and " five god " and " five will " belongs to " the five internal organs ", is commanded by the heart." element is asked and is declared five gas pieces of writing ": visceral stroage, heart storing spirit, lung storing inferior spirit, liver storing soul, idea stored in the spleen, kidney storing will, so-called god, soul, soul, meaning, will are referred to as five god.The people has the five internal organs, changes five gas, giving birth to happiness, anger, compassion, melancholy, to fear, i.e. and five will, and think that liver is an anger in will, emotion of the heart being joy, the emotion of the spleen being anxiety, the mental change of the lung being worry, the emotion of the kidney being fear.Above-mentioned " five god " has proposed theoretical explanation with " five gas " for ergasia." interior warp " also discussed under violent feelings will changes, and can cause psychological problem, and influenced normal function in the body, and same somaticosplanchnic variation also can be involved emotion.If any so-called " all diseases resulting from disorder of QI " rage impairing liver, big excessive joy impairing the heart, worry impairing spleen, melancholy impairing lung, the internal injury caused by excess of seven emotions opinion of fear impairing kidney.Mad disease (be exactly Western medicine diagnose the be schizoid mental symptom content) sun that belong to more, the demented branch that negative and positive are arranged, the Double Ninth Festival, the person was mad, and overabundant yin person is insane.Therefore, treatment should be taked the method for heat-clearing and toxic substances removing, cool liver arresting convulsion, loosening bowel to relieve constipation, the refreshment of having one's ideas straightened out.In the prescription of the present invention, Radix Gentianae heat clearing and damp drying, eliminating pathogen in the liver arresting convulsion; The Aloe removing heat from the liver, relieving constipation; Chinese angelica blood supplementing is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation; Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae clearing away heat-fire, dampness detoxifcation, the HEIZHIZI invigorating the spleen and replenishing QI, remove blood stasis, that Radix Et Rhizoma Rhei is attacked is stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, detoxifcation, Radix Aucklandiae warming middle-JIAO to promote flow of QI, Indigo Naturalis heat-clearing and toxic substances removing, removing heat from blood arresting convulsion, the refreshment of Moschus key, promoting blood circulation to restore menstrual flow, pain relieving, clozapine are used to control psychotic hallucination, vain hope and excited restless.All medicine compatibilities, heat-clearing and toxic substances removing, cool liver arresting convulsion, loosening bowel to relieve constipation, the refreshment of having one's ideas straightened out.
Medicine of the present invention had both been brought into play the psychosis Western medicine and had been acted on fast and effectively, again at the theory of Chinese medical science of mad disease, use the principle of Chinese medicine heat clearing away and internal heat reducing, finally reach the purpose of healing, do not need the consolidation of taking medicine for a long time after the healing, reduced and taken Western medicine for a long time and cause murder by poisoning side effect, thoroughly solved the trouble and worry of psychotic's stress and long-term clothes psychosis Western medicine the heart, liver, spleen, lung, kidney.
For further investigating the clinical efficacy and the safety of medicine of the present invention, we select 100 routine psychiatric patients, and the curative effect of medicine of the present invention is carried out clinical observation.
In the MethodsThe cases enrolled 100 routine cases, male 32 examples, women 68 examples; Age is based on 16～55 years old, and maximum 55 years old, minimum 16 years old; Year surplus the course of disease weak point person 1, several 10 years of elder.Be divided into two groups at random, every group 50 example.Two groups of cases at aspects such as sex, age, the courses of disease by statistics credit analyse the difference not statistically significant.The diagnosis reference " psychiatry " of all cases, and meet diagnostic criteria.
The Therapeutic Method matched group gives lithium carbonate 0.5g/d treatment.The treatment group gives drug oral of the present invention, and each 2, every day 2 times.
Efficacy evaluation subtracts with the mania scale and is divided into foundation, subtracts branch 〉=90.12% for curing.63.58% is produce effects, and 35.36% is that effectively＜35.36% is invalid.
Curative effect comparative result after two groups of cases are treated sees Table 1.
Table 1 liang group case treatment back curative effect relatively
The specific embodiment
Embodiment 1
Get the Radix Gentianae 6Kg that chooses most impurity, dry in the sun oven dry, Aloe 5Kg, Radix Angelicae Sinensis 3Kg, Rhizoma Coptidis 2Kg, Cortex Phellodendri 3Kg, Radix Scutellariae 3Kg, HEIZHIZI 1Kg, Radix Et Rhizoma Rhei 1Kg, Radix Aucklandiae 3Kg, Indigo Naturalis 4Kg, Moschus 1Kg with clozapine 1Kg mix homogeneously, are ground into 200 purpose fine powders, make capsule in incapsulating.Usage: take 2, every day 2 times, oral meal is mainly used in the mad disease of treatment at every turn.
Embodiment 2
Get the Radix Gentianae 4Kg that chooses most impurity, dry in the sun oven dry, Aloe 3Kg, Radix Angelicae Sinensis 4Kg, Rhizoma Coptidis 3Kg, Cortex Phellodendri 2Kg, Radix Scutellariae 2Kg, HEIZHIZI 2Kg, Radix Et Rhizoma Rhei 2Kg, Radix Aucklandiae 4Kg, Indigo Naturalis 3Kg, Moschus 1Kg with clozapine 1Kg mix homogeneously, are ground into 200 purpose fine powders, make capsule in incapsulating.
Embodiment 3
Get the Radix Gentianae 5Kg that chooses most impurity, dry in the sun oven dry, Aloe 4Kg, Radix Angelicae Sinensis 4Kg, Rhizoma Coptidis 1Kg, Cortex Phellodendri 3Kg, Radix Scutellariae 2Kg, HEIZHIZI 1Kg, Radix Et Rhizoma Rhei 1Kg, Radix Aucklandiae 4Kg, Indigo Naturalis 4Kg, Moschus 1Kg with clozapine 1Kg mix homogeneously, are ground into 200 purpose fine powders, make capsule in incapsulating.
Claims (3)
1. one kind is used for the treatment of psychotic medicine, is that the component by following parts by weight is that crude drug prepares:
Radix Gentianae 30～60 Aloes 30～50
Radix Angelicae Sinensis 30～40 Rhizoma Coptidis 10～30
Cortex Phellodendri 10～30 Radix Scutellariaes 20～30
HEIZHIZI 10～20 Radix Et Rhizoma Rhei 10～20
The Radix Aucklandiae 30～40 Indigo Naturaliss 30～40
Moschus 10～15 clozapines 10～15.
2. according to claim 1ly be used for the treatment of psychotic medicine, it is characterized in that described medicine is made capsule.
3. the described preparation method that is used for the treatment of psychotic medicine of claim 2, it is characterized in that getting Radix Gentianae, Aloe, Radix Angelicae Sinensis, Rhizoma Coptidis, Cortex Phellodendri, Radix Scutellariae, HEIZHIZI, Radix Et Rhizoma Rhei, the Radix Aucklandiae, Indigo Naturalis, Moschus, the clozapine mix homogeneously of described parts by weight, be ground into 200 fine powder, make capsule in incapsulating.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105257451A CN101979039A (en) | 2010-10-26 | 2010-10-26 | Medicine for treating mental disease |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105257451A CN101979039A (en) | 2010-10-26 | 2010-10-26 | Medicine for treating mental disease |
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| CN101979039A true CN101979039A (en) | 2011-02-23 |
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| CN2010105257451A Pending CN101979039A (en) | 2010-10-26 | 2010-10-26 | Medicine for treating mental disease |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772554A (en) * | 2012-08-03 | 2012-11-14 | 西安市精神卫生中心 | Traditional Chinese medicine compound for curing schizophrenia |
| CN102961534A (en) * | 2012-12-22 | 2013-03-13 | 陈洪振 | Traditional Chinese medicine composition for treating schizophrenia in stage of attack and preparation method thereof |
| CN105688066A (en) * | 2016-03-18 | 2016-06-22 | 杭州富阳飞博科技有限公司 | Preparation for psychosis and preparing method of preparation |
Citations (4)
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| CN101322793A (en) * | 2007-06-13 | 2008-12-17 | 张正中 | Special cure for cancer lesion |
| CN101417033A (en) * | 2008-11-25 | 2009-04-29 | 山西省长治精神病院 | Traditional Chinese medicine for treating insomnia |
| CN101417048A (en) * | 2008-11-25 | 2009-04-29 | 山西省长治精神病院 | Traditional Chinese medicine for treating senile psychosis |
| CN101461861A (en) * | 2008-12-26 | 2009-06-24 | 王海燕 | Chinese angelica aloe pills and preparation method thereof |
-
2010
- 2010-10-26 CN CN2010105257451A patent/CN101979039A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101322793A (en) * | 2007-06-13 | 2008-12-17 | 张正中 | Special cure for cancer lesion |
| CN101417033A (en) * | 2008-11-25 | 2009-04-29 | 山西省长治精神病院 | Traditional Chinese medicine for treating insomnia |
| CN101417048A (en) * | 2008-11-25 | 2009-04-29 | 山西省长治精神病院 | Traditional Chinese medicine for treating senile psychosis |
| CN101461861A (en) * | 2008-12-26 | 2009-06-24 | 王海燕 | Chinese angelica aloe pills and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 《中国社区医师（医学专业）》 20100530 卞西兰 精神分裂症药物治疗的选择 12 1-3 , 第15期 2 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102772554A (en) * | 2012-08-03 | 2012-11-14 | 西安市精神卫生中心 | Traditional Chinese medicine compound for curing schizophrenia |
| CN102772554B (en) * | 2012-08-03 | 2015-04-22 | 西安市精神卫生中心 | Traditional Chinese medicine compound for curing schizophrenia |
| CN102961534A (en) * | 2012-12-22 | 2013-03-13 | 陈洪振 | Traditional Chinese medicine composition for treating schizophrenia in stage of attack and preparation method thereof |
| CN105688066A (en) * | 2016-03-18 | 2016-06-22 | 杭州富阳飞博科技有限公司 | Preparation for psychosis and preparing method of preparation |
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Open date: 20110223 |