CN101974107B - 一种酯化物的分离方法 - Google Patents
一种酯化物的分离方法 Download PDFInfo
- Publication number
- CN101974107B CN101974107B CN2010102871441A CN201010287144A CN101974107B CN 101974107 B CN101974107 B CN 101974107B CN 2010102871441 A CN2010102871441 A CN 2010102871441A CN 201010287144 A CN201010287144 A CN 201010287144A CN 101974107 B CN101974107 B CN 101974107B
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- Prior art keywords
- precipitate
- ethanol
- throw out
- amount
- purified water
- Prior art date
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- 238000000034 method Methods 0.000 title abstract description 7
- 150000002148 esters Chemical class 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000006228 supernatant Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 239000008213 purified water Substances 0.000 claims abstract description 8
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960000610 enoxaparin Drugs 0.000 claims abstract description 6
- 230000032050 esterification Effects 0.000 claims abstract description 5
- 238000005886 esterification reaction Methods 0.000 claims abstract description 5
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 claims abstract description 4
- 238000001556 precipitation Methods 0.000 claims abstract description 4
- 235000017281 sodium acetate Nutrition 0.000 claims abstract description 4
- 239000001632 sodium acetate Substances 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 230000008021 deposition Effects 0.000 claims description 9
- 150000007942 carboxylates Chemical class 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000000047 product Substances 0.000 abstract description 4
- 239000002341 toxic gas Substances 0.000 abstract description 4
- 239000002244 precipitate Substances 0.000 abstract 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 229960005153 enoxaparin sodium Drugs 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- CIJQTPFWFXOSEO-NDMITSJXSA-J tetrasodium;(2r,3r,4s)-2-[(2r,3s,4r,5r,6s)-5-acetamido-6-[(1r,2r,3r,4r)-4-[(2r,3s,4r,5r,6r)-5-acetamido-6-[(4r,5r,6r)-2-carboxylato-4,5-dihydroxy-6-[[(1r,3r,4r,5r)-3-hydroxy-4-(sulfonatoamino)-6,8-dioxabicyclo[3.2.1]octan-2-yl]oxy]oxan-3-yl]oxy-2-(hydroxy Chemical compound [Na+].[Na+].[Na+].[Na+].O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1O)NC(C)=O)O[C@@H]1C(C[C@H]([C@@H]([C@H]1O)O)O[C@@H]1[C@@H](CO)O[C@H](OC2C(O[C@@H](OC3[C@@H]([C@@H](NS([O-])(=O)=O)[C@@H]4OC[C@H]3O4)O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](NC(C)=O)[C@H]1C)C([O-])=O)[C@@H]1OC(C([O-])=O)=C[C@H](O)[C@H]1O CIJQTPFWFXOSEO-NDMITSJXSA-J 0.000 description 2
- 101000712605 Theromyzon tessulatum Theromin Proteins 0.000 description 1
- 229940122388 Thrombin inhibitor Drugs 0.000 description 1
- 230000001858 anti-Xa Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 description 1
- 229960001008 heparin sodium Drugs 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN2010102871441A CN101974107B (zh) | 2010-09-16 | 2010-09-16 | 一种酯化物的分离方法 |
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CN2010102871441A CN101974107B (zh) | 2010-09-16 | 2010-09-16 | 一种酯化物的分离方法 |
Publications (2)
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CN101974107A CN101974107A (zh) | 2011-02-16 |
CN101974107B true CN101974107B (zh) | 2012-07-04 |
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CN2010102871441A Active CN101974107B (zh) | 2010-09-16 | 2010-09-16 | 一种酯化物的分离方法 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3724235B1 (en) | 2017-12-11 | 2024-08-07 | Biological E Limited | Process for the preparation of low molecular weight heparin |
CN109293800B (zh) * | 2018-08-16 | 2022-02-25 | 山东万邦赛诺康生化制药股份有限公司 | 一种肝素卞酯生产过程中氯化苄味道去除办法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101165071A (zh) * | 2006-10-20 | 2008-04-23 | 江苏江山制药有限公司 | 依诺肝素及其制备方法 |
CN101463095A (zh) * | 2007-12-20 | 2009-06-24 | 大英县茂森生物化工厂 | 肝素生产新工艺 |
CN101824099A (zh) * | 2010-02-12 | 2010-09-08 | 淮安麦德森化学有限公司 | 一种粗品肝素钠的纯化方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09143199A (ja) * | 1995-11-17 | 1997-06-03 | Nippon Chem Res Kk | 血小板第4因子の製造方法 |
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2010
- 2010-09-16 CN CN2010102871441A patent/CN101974107B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101165071A (zh) * | 2006-10-20 | 2008-04-23 | 江苏江山制药有限公司 | 依诺肝素及其制备方法 |
CN101463095A (zh) * | 2007-12-20 | 2009-06-24 | 大英县茂森生物化工厂 | 肝素生产新工艺 |
CN101824099A (zh) * | 2010-02-12 | 2010-09-08 | 淮安麦德森化学有限公司 | 一种粗品肝素钠的纯化方法 |
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Owner name: DONGYING TIANDONG BIOCHEMICAL INDUSTRY CO., LTD. |
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CB03 | Change of inventor or designer information |
Inventor after: Yang Xiaohong Inventor after: Zhang Zaizhong Inventor after: Guo Lin Inventor after: Li Rong Inventor after: Wang Chunmei Inventor after: Liu Wei Inventor after: Li Jiayao Inventor after: Wang Xiuping Inventor before: Liu Wei Inventor before: Li Jiayao Inventor before: Wang Xiuping |
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Free format text: CORRECT: INVENTOR; FROM: LIU WEI LI JIAYAO WANG XIUPING TO: YANG XIAOHONG ZHANG ZAIZHONG GUO LIN LI RONG WANG CHUNMEI LIU WEI LI JIAYAO WANG XIUPING |
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Effective date of registration: 20110927 Address after: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Applicant after: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Co-applicant after: DONGYING TIANDONG BIOCHEMICAL INDUSTRY Co.,Ltd. Address before: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Applicant before: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. |
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Effective date of registration: 20120914 Address after: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Patentee after: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Patentee after: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Address before: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Patentee before: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Patentee before: DONGYING TIANDONG BIOCHEMICAL INDUSTRY Co.,Ltd. |
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Address after: 257000 West of HaoChun Road, Dongying District, Dongying City, Shandong Province Patentee after: Shandong Haike Chemical Co.,Ltd. Patentee after: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Address before: 257000 Shandong District of Dongying city in Dongying Province North Road No. 726 in the building Patentee before: SHANDONG HI-TECH CHEMICAL GROUP Co.,Ltd. Patentee before: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. |
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Effective date of registration: 20201030 Address after: 257000 No. two, 1236 South Road, Dongying District, Shandong, Dongying Patentee after: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. Address before: 257000 West of HaoChun Road, Dongying District, Dongying City, Shandong Province Patentee before: Shandong Haike Chemical Co.,Ltd. Patentee before: DONGYING TIANDONG PHARMACEUTICAL Co.,Ltd. |