CN101972277A - Preparation process of bee glue injection - Google Patents
Preparation process of bee glue injection Download PDFInfo
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- CN101972277A CN101972277A CN2010105155316A CN201010515531A CN101972277A CN 101972277 A CN101972277 A CN 101972277A CN 2010105155316 A CN2010105155316 A CN 2010105155316A CN 201010515531 A CN201010515531 A CN 201010515531A CN 101972277 A CN101972277 A CN 101972277A
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- propolis
- injection
- solution
- bee glue
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Abstract
The invention relates to a preparation process of a bee glue injection, which comprises the following steps of: 1, crushing; 2, dissolving: adding a solvent in a clean distributing tank, soaking the extracted bee glue extract into the solvent, and stirring over the night to ensure that the crushed bee glue extract is fully dissolved; or heating to 60 DEG C, stirring until the crushed bee glue extract is fully dissolved, standing, cooling to room temperature, and metering the volume; 3, regulating the pH value of a bee glue extract solution, measuring the pH value of the bee glue extract solution, regulating with less NN-dimethylacetylamide until the pH value is 7.0; 4, filtering: filtering the bee glue extract with a 0.8mu m filter film; 5, encapsulating: encapsulating the bee glue extract into a 20ml solution/ampoule bottle; and 6, sterilizing. The bee glue extract is prepared into a uniform and stable solution, and used for improving the immunity of livestock and enhancing the premunition of the livestock through intramuscular injection or oral administration.
Description
Technical field
The present invention relates to a kind of preparation technology of propolis injection, be used to promote domestic animal immunity, strengthen the domestic animal premunition.
Background technology
Propolis derives from secreted natural gum of plant and resinae material, and after Apis is gathered, adds Cera Flava and the formed a kind of brown jelly of Apis maxillary secretions, is called as " purple gold ".Propolis contains hundreds of natural components.Mainly consisting of of fresh propolis: 50% resin and balsam, 30% Cera Flava, 10% fragrant volatile oil, 5% pollen, other materials (comprising organic acid, fatty acid, aminoacid, mineral element, vitamin, phytocide and enzyme etc.) of 5%.Propolis is a kind of natural active substance, and its composition is very complicated, contains flavonoid, terpenes, ketone, esters, alcohols, phenols, ethers, organic acid and a large amount of aminoacid, enzyme, VB class, VE and VA, and mineral etc.Propolis has biologic activity widely: (1) resisting pathogenic microbes activity: cause of diseases such as opposing antibacterial, virus, fungus, protozoon, nematicide participate in the body anti-infectious immunity; (2) toxin expelling activity: propolis can be got rid of the inside and outside toxin of body, protects kidney, protects the liver, cardiac stimulant effect; The activity of (3) inducing sweat: spasmolytic, calmness, antiinflammatory, pain relieving are arranged; (4) antioxidative activity: eliminate free radical, suppress the peroxidating of body inner lipid, improve resisting stress capability and to the adaptive capacity of envirment factor; (5) tissue repair activity: repair skin, mucosa, antiulcer, promotion tissue regeneration improve the body defence capability; (6) regulate immune activity: enhance immunity cytoactive, good immunological adjuvant and immunostimulant, immunity of two-ways regulation body cell and humoral immunization.
At present, propolis has been widely used in aspects such as medical and health, food industry, daily-use chemical industry, animal husbandry.Many national health departments approval propolis is health food or medicine, and propolis does not influence food safety, human body is had no side effect, and noresidue, the growth and the poultry that do not influence animal are laid eggs, even the trend of raising is arranged; The propolis product environmental protection.
Summary of the invention
The technical problem to be solved in the present invention is a kind of propolis injection of development, and this solution can be by domestic animal drinking-water or direct oral administration, and the affected part is smeared administration or through spray delivery, improved domestic animal immunity to reach, and strengthens the purpose of domestic animal premunition.
The preparation technology of propolis injection of the present invention comprises the steps:
1), pulverizes: propolis extract is placed the plastic film bag of cleaning, break into pieces with hammer;
2), dissolving: add the solvent of prescription amount in the Agitation Tank of cleaning, the propolis extract that step 1) is pulverized soaks wherein, and stirring spends the night makes dissolving fully; Or be heated to 60 ℃, and be stirred to dissolving fully, leave standstill, be cooled to room temperature, standardize solution;
3), the solution pH value is regulated: measure the pH value of propolis extract solution, being adjusted to pH value with small amount of N N-dimethyl acetylamide is 7.0;
4), sucking filtration: with propolis extract solution through 0.8 μ m filter membrane sucking filtration;
5), embedding: with the embedding of step 4) gained propolis extract solution is that 20ml/ props up ampoule bottle solution;
6), sterilization: the propolis extract solution that embedding is good is sterilized 1.0 * 10 through autoclaving
5The handkerchief vapour pressure, was sterilized 15 minutes by 115 ℃.
The preparation technology of propolis injection of the present invention, step 2) in, the solvent of described prescription amount is glyceryl triacetate, methanol, propylene glycol double solvents.
The preparation technology of propolis injection of the present invention, step 2) in, the solvent of described prescription amount is propylene glycol, ethanol double solvents.
Further, a kind of content specification of propolis injection, the content specification of propolis injection comprises 3 kinds: 5% propolis injection (g/v), 8% propolis injection (g/v) and 10% propolis injection (g/v).
Further, a kind of route of administration of propolis injection, the clinical practice of propolis injection can be by following approach:
(1) intramuscular injection: domestic animal 0.1～0.2ml/kg body weight;
(2) oral administration: domestic animal 0.2ml/kg body weight.
The preparation technology's of propolis injection of the present invention beneficial effect is: technical scheme of the present invention is that propolis extract is pulverized, and soaked in solvent spends the night or heated and stirred to propolis extract dissolves fully, through sucking filtration, embedding, sterilization, is the propolis injection.
The present invention is the solution that propolis extract is prepared into stable homogeneous, by intramuscular injection or oral administration, is used to improve domestic animal immunity, strengthens the premunition of domestic animal.Preparation technology of the present invention is simple, and the Product Green environmental protection has no side effect.
The specific embodiment
Preparation technology to propolis injection of the present invention is described further below.
With 100L, 10% propolis injection example:
Embodiment 1
The preparation technology of propolis injection of the present invention comprises the steps:
1), pulverizes:, break into pieces with hammer with the plastic film bag that propolis extract 10kg places cleaning;
2), dissolving: add glyceryl triacetate, propylene glycol double solvents in the Agitation Tank of cleaning, be settled to 100L, the propolis extract that step 1) is pulverized soaks wherein, and stirring spends the night makes dissolving fully; Or be heated to 60 ℃, and be stirred to dissolving fully, leave standstill, be cooled to room temperature, standardize solution;
3), the solution pH value is regulated: measure the pH value of propolis extract solution, being adjusted to pH value with small amount of N N-dimethyl acetylamide is 7.0;
4), sucking filtration: with propolis extract solution through 0.8 μ m filter membrane sucking filtration;
5), embedding: with the embedding of step 4) gained propolis extract solution is that 20ml/ props up ampoule bottle solution;
6), sterilization: the propolis extract solution that embedding is good is sterilized through autoclaving, and 1.0 * 105 handkerchief vapour pressures, were sterilized 15 minutes by 115 ℃.
7), preserve: room temperature storage, expiry date are 2 years.
Propolis injection content specification involved in the present invention comprises: (1) 5% propolis injection (g/v); (2) 8% propolis injection (g/v); (3) 10% propolis injection (g/v).
Embodiment 2
Be with the embodiment difference: present embodiment step 2), adding prescription amount solvent in the Agitation Tank of cleaning is propylene glycol, ethanol double solvents, is settled to 100L.
Propolis injection formula 2 applied double solventss involved in the present invention can quicken the dissolving of propolis extract, reduce the viscosity of propolis extract solution simultaneously, are more conducive to production practices.
The clinical practice of propolis injection involved in the present invention can be by following approach:
(1) intramuscular injection: domestic animal 0.1～0.2ml/kg body weight
(2) oral administration: domestic animal 0.2ml/kg body weight
Above embodiment is described preferred implementation of the present invention; be not that scope of the present invention is limited; design under the prerequisite of spirit not breaking away from the present invention; various distortion and improvement that the common engineers and technicians in this area make technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (5)
1. the preparation technology of a propolis injection is characterized in that, comprises the steps:
1), pulverizes: propolis extract is placed the plastic film bag of cleaning, break into pieces with hammer;
2), dissolving: add the solvent of prescription amount in the Agitation Tank of cleaning, the propolis extract that step 1) is pulverized soaks wherein, and stirring spends the night makes dissolving fully; Or be heated to 60 ℃, and be stirred to dissolving fully, leave standstill, be cooled to room temperature, standardize solution;
3), the solution pH value is regulated: measure the pH value of propolis extract solution, being adjusted to pH value with small amount of N N-dimethyl acetylamide is 7.0;
4), sucking filtration: with propolis extract solution through 0.8 μ m filter membrane sucking filtration;
5), embedding: with the embedding of step 4) gained propolis extract solution is that 20ml/ props up ampoule bottle solution;
6), sterilization: the propolis extract solution that embedding is good is sterilized 1.0 * 10 through autoclaving
5The handkerchief vapour pressure, was sterilized 15 minutes by 115 ℃.
2. the preparation technology of propolis injection according to claim 1 is characterized in that step 2) in, the solvent of described prescription amount is glyceryl triacetate, methanol, propylene glycol double solvents.
3. the preparation technology of propolis injection according to claim 1 is characterized in that step 2) in, the solvent of described prescription amount is propylene glycol, ethanol double solvents.
4. the content specification of a propolis injection is characterized in that, the content specification of propolis injection comprises 3 kinds: 5% propolis injection (g/v), 8% propolis injection (g/v) and 10% propolis injection (g/v).
5. the route of administration of a propolis injection is characterized in that, the clinical practice of propolis injection can be by following approach:
(1) intramuscular injection: domestic animal 0.1～0.2m1/kg body weight;
(2) oral administration: domestic animal 0.2ml/kg body weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105155316A CN101972277A (en) | 2010-10-22 | 2010-10-22 | Preparation process of bee glue injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105155316A CN101972277A (en) | 2010-10-22 | 2010-10-22 | Preparation process of bee glue injection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101972277A true CN101972277A (en) | 2011-02-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105155316A Pending CN101972277A (en) | 2010-10-22 | 2010-10-22 | Preparation process of bee glue injection |
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| Country | Link |
|---|---|
| CN (1) | CN101972277A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107028992A (en) * | 2017-05-10 | 2017-08-11 | 河南牧业经济学院 | Compound bee-glue parenteral solution and preparation method thereof |
-
2010
- 2010-10-22 CN CN2010105155316A patent/CN101972277A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107028992A (en) * | 2017-05-10 | 2017-08-11 | 河南牧业经济学院 | Compound bee-glue parenteral solution and preparation method thereof |
| CN107028992B (en) * | 2017-05-10 | 2020-12-15 | 河南牧业经济学院 | Compound propolis injection and preparation method thereof |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Jinping Document name: Notification of Passing Preliminary Examination of the Application for Invention |
|
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Zhao Jinping Document name: Notification of Publication and of Entering the Substantive Examination Stage of the Application for Invention |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20110216 |