CN101959450B - 通过基于图像的x射线引导系统 - Google Patents
通过基于图像的x射线引导系统 Download PDFInfo
- Publication number
- CN101959450B CN101959450B CN2009801076626A CN200980107662A CN101959450B CN 101959450 B CN101959450 B CN 101959450B CN 2009801076626 A CN2009801076626 A CN 2009801076626A CN 200980107662 A CN200980107662 A CN 200980107662A CN 101959450 B CN101959450 B CN 101959450B
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- CN
- China
- Prior art keywords
- needle
- biopsy
- optical
- tissue
- biopsy device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4375—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the male reproductive system
- A61B5/4381—Prostate evaluation or disorder diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/12—Arrangements for detecting or locating foreign bodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
- A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Clinical applications
- A61B8/0833—Clinical applications involving detecting or locating foreign bodies or organic structures
- A61B8/0841—Clinical applications involving detecting or locating foreign bodies or organic structures for locating instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/361—Image-producing devices, e.g. surgical cameras
- A61B2090/3614—Image-producing devices, e.g. surgical cameras using optical fibre
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/032—Transmission computed tomography [CT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Computer Vision & Pattern Recognition (AREA)
- High Energy & Nuclear Physics (AREA)
- Optics & Photonics (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152217.9 | 2008-03-03 | ||
| EP08152217 | 2008-03-03 | ||
| EP08157678.7 | 2008-06-05 | ||
| EP08157678 | 2008-06-05 | ||
| PCT/IB2009/050752 WO2009109873A1 (en) | 2008-03-03 | 2009-02-25 | Biopsy guidance by image-based x-ray guidance system and photonic needle |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101959450A CN101959450A (zh) | 2011-01-26 |
| CN101959450B true CN101959450B (zh) | 2013-05-29 |
Family
ID=40565037
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801076626A Active CN101959450B (zh) | 2008-03-03 | 2009-02-25 | 通过基于图像的x射线引导系统 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20100331782A1 (https=) |
| EP (1) | EP2259716B1 (https=) |
| JP (1) | JP5587798B2 (https=) |
| CN (1) | CN101959450B (https=) |
| WO (1) | WO2009109873A1 (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006119431A2 (en) | 2005-04-29 | 2006-11-09 | The Regents Of The University Of Colorado, A Body Corporate | Electromagnetic characterization of tissue |
| EP2249737B1 (en) * | 2008-03-03 | 2020-07-01 | Koninklijke Philips N.V. | Biopsy guidance by electromagnetic tracking and photonic needle |
| EP2259716B1 (en) | 2008-03-03 | 2014-07-02 | Koninklijke Philips N.V. | Biopsy guidance by image-based x-ray guidance system and photonic needle |
| EP2408375B1 (en) | 2009-03-20 | 2017-12-06 | Orthoscan Incorporated | Moveable imaging apparatus |
| JP5658747B2 (ja) * | 2009-05-28 | 2015-01-28 | コーニンクレッカ フィリップス エヌ ヴェ | 針装置を用いるインターベンション中の記録済画像の再較正 |
| DE102009060921A1 (de) * | 2009-12-31 | 2011-08-18 | Bader, Markus, Dr., 81825 | Punktionsnadelsystem |
| WO2011089537A1 (en) * | 2010-01-19 | 2011-07-28 | Koninklijke Philips Electronics N.V. | Imaging apparatus |
| US8483802B2 (en) * | 2010-03-25 | 2013-07-09 | Medtronic, Inc. | Method and apparatus for guiding an external needle to an implantable device |
| US9216257B2 (en) | 2010-03-25 | 2015-12-22 | Medtronic, Inc. | Method and apparatus for guiding an external needle to an implantable device |
| US9339601B2 (en) | 2010-03-25 | 2016-05-17 | Medtronic, Inc. | Method and apparatus for guiding an external needle to an implantable device |
| US8475407B2 (en) | 2010-03-25 | 2013-07-02 | Medtronic, Inc. | Method and apparatus for guiding an external needle to an implantable device |
| JP5802264B2 (ja) * | 2010-05-19 | 2015-10-28 | コーニンクレッカ フィリップス エヌ ヴェ | 標本画像処理システム、方法、及びコンピュータプログラム |
| WO2012082799A1 (en) | 2010-12-13 | 2012-06-21 | Orthoscan, Inc. | Mobile fluoroscopic imaging system |
| BR112014000383A2 (pt) * | 2011-07-11 | 2017-02-14 | Koninklijke Philips Nv | aparelho, método e programa de computador de planejamento de aplicação de energia |
| CN102894994A (zh) * | 2011-07-25 | 2013-01-30 | 滕学东 | 超声探头保护膜 |
| CN103781410B (zh) * | 2011-09-08 | 2018-10-02 | 皇家飞利浦有限公司 | 具有集成在可移动插入物中的光纤的针装置 |
| JP6232044B2 (ja) * | 2012-03-23 | 2017-11-15 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 針変位速度に基づかれる測定集積時間を用いるフォトニック針システム |
| US9468380B2 (en) | 2012-03-30 | 2016-10-18 | Children's Hospital Medical Center | Method to identify tissue oxygenation state by spectrographic analysis |
| EP3574835A1 (en) * | 2012-05-21 | 2019-12-04 | The Regents of the University of Colorado, a body corporate | Three-dimensional mapping of prostate cancer |
| US9814448B2 (en) * | 2012-05-21 | 2017-11-14 | Precision Biopsy, Inc. | Three-dimensional optical imaging and therapy of prostate cancer |
| US20140100550A1 (en) * | 2012-10-10 | 2014-04-10 | Christie Digital Systems Canada Inc. | Catheter discrimination and guidance system |
| JP5911649B2 (ja) | 2012-11-02 | 2016-04-27 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 病理情報を取得するためのフォトニック生検デバイスを備えたシステム |
| CN104955394B (zh) * | 2013-01-22 | 2018-04-10 | 东芝医疗系统株式会社 | X射线诊断装置以及超声波诊断装置 |
| JP2015016300A (ja) * | 2013-06-13 | 2015-01-29 | キヤノン株式会社 | 生検支援装置及び生検支援方法 |
| US10460999B2 (en) * | 2013-11-27 | 2019-10-29 | Taiwan Semiconductor Manufacturing Co., Ltd. | Metrology device and metrology method thereof |
| DE102014107342B4 (de) | 2014-05-24 | 2023-05-04 | Frank Braun | Vorrichtung und Verfahren zur Erkennung von Krebstumoren und anderen Gewebeveränderungen |
| EP3182875B1 (en) * | 2014-08-23 | 2021-04-07 | Intuitive Surgical Operations, Inc. | Systems for display of pathological data in an image guided procedure |
| US10405838B2 (en) * | 2014-08-28 | 2019-09-10 | Koninklijke Philips N.V. | Side-looking lung biopsy device |
| GB2555012B (en) * | 2015-03-17 | 2020-09-09 | Synaptive Medical Barbados Inc | Method and device for registering surgical images |
| CN104840255A (zh) * | 2015-04-02 | 2015-08-19 | 管勇 | 颅底肿瘤立体定向手术装置 |
| WO2016198626A1 (en) * | 2015-06-12 | 2016-12-15 | Koninklijke Philips N.V. | Dose planning system |
| WO2017007870A1 (en) | 2015-07-07 | 2017-01-12 | Precision Biopsy, Inc. | Motorized optical imaging of prostate cancer |
| US10702226B2 (en) * | 2015-08-06 | 2020-07-07 | Covidien Lp | System and method for local three dimensional volume reconstruction using a standard fluoroscope |
| US10743848B2 (en) | 2015-09-25 | 2020-08-18 | The Regents Of The University Of Michigan | Biopsy device for coherent Raman imaging |
| US11357405B2 (en) | 2015-12-21 | 2022-06-14 | Erasmus University Medical Center Rotterdam | Optical probe for measuring a tissue sample |
| CN106388910B (zh) * | 2016-08-31 | 2018-02-16 | 北京数字精准医疗科技有限公司 | 内窥式荧光成像辅助穿刺系统 |
| WO2019147908A1 (en) * | 2018-01-26 | 2019-08-01 | Diagnostic Photonics, Inc. | Method and apparatus for classifying core biopsy specimens with optical coherence tomography |
| CN109523867B (zh) * | 2018-11-21 | 2021-03-09 | 杨天烈 | 一种手环式奶牛直肠定位检查教学装置及教学方法 |
| CN109481018A (zh) * | 2018-12-29 | 2019-03-19 | 上海联影医疗科技有限公司 | 一种应用在医疗操作中的导航设备及方法 |
| CN115644951B (zh) * | 2022-11-20 | 2025-01-28 | 成都真实维度科技有限公司 | 一种基于实时建模的精准穿刺取样系统 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6564087B1 (en) * | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
| WO2006116163A2 (en) * | 2005-04-21 | 2006-11-02 | Biotelligent Inc. | Ultrasound guided tissue measurement system |
| US20070238997A1 (en) * | 2006-03-29 | 2007-10-11 | Estelle Camus | Ultrasound and fluorescence imaging |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5318023A (en) | 1991-04-03 | 1994-06-07 | Cedars-Sinai Medical Center | Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle |
| US5495541A (en) * | 1994-04-19 | 1996-02-27 | Murray; Steven C. | Optical delivery device with high numerical aperture curved waveguide |
| US5638819A (en) * | 1995-08-29 | 1997-06-17 | Manwaring; Kim H. | Method and apparatus for guiding an instrument to a target |
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| US5846513B1 (en) * | 1997-07-08 | 2000-11-28 | Carewise Medical Products Corp | Tumor localization and removal system using penetratable detection probe and removal instrument |
| IL122336A0 (en) * | 1997-11-27 | 1998-04-05 | Ultra Guide Ltd | System and method for guiding the movements of a device to a target particularly for medical applications |
| US6538726B2 (en) * | 1998-07-10 | 2003-03-25 | Lj Laboratories, Llc | Apparatus and method for measuring optical characteristics of an object |
| JP3749400B2 (ja) * | 1998-10-27 | 2006-02-22 | 株式会社島津製作所 | 断層撮影装置 |
| US6689142B1 (en) * | 1999-04-26 | 2004-02-10 | Scimed Life Systems, Inc. | Apparatus and methods for guiding a needle |
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| AU2001251134B2 (en) | 2000-03-31 | 2006-02-02 | Angiodynamics, Inc. | Tissue biopsy and treatment apparatus and method |
| DE10050648C2 (de) | 2000-10-12 | 2003-11-06 | Fraunhofer Ges Forschung | Chirurgisches Instrument |
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| EP1691666B1 (en) * | 2003-12-12 | 2012-05-30 | University of Washington | Catheterscope 3d guidance and interface system |
| US20050203419A1 (en) * | 2004-02-24 | 2005-09-15 | Nirmala Ramanujam | Side-firing probe for performing optical spectroscopy during core needle biopsy |
| JP4724883B2 (ja) * | 2004-05-24 | 2011-07-13 | 独立行政法人産業技術総合研究所 | 生体内組織の同定装置 |
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| JP4997387B2 (ja) * | 2006-04-21 | 2012-08-08 | 独立行政法人産業技術総合研究所 | 侵襲性器具の生体内位置同定システム |
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| JP2008099923A (ja) * | 2006-10-20 | 2008-05-01 | Kazunori Nosaka | 治療装置 |
| EP2091416A1 (en) * | 2006-12-06 | 2009-08-26 | Koninklijke Philips Electronics N.V. | Obtaining optical tissue properties |
| JP4992030B2 (ja) * | 2007-06-12 | 2012-08-08 | 株式会社パイロットコーポレーション | 生体用針体 |
| US8041005B2 (en) * | 2007-09-28 | 2011-10-18 | The Invention Science Fund I, Llc | X-ray fluorescence visualizer, imager, or information provider |
| EP2259716B1 (en) | 2008-03-03 | 2014-07-02 | Koninklijke Philips N.V. | Biopsy guidance by image-based x-ray guidance system and photonic needle |
| EP2249737B1 (en) | 2008-03-03 | 2020-07-01 | Koninklijke Philips N.V. | Biopsy guidance by electromagnetic tracking and photonic needle |
-
2009
- 2009-02-25 EP EP09718103.6A patent/EP2259716B1/en active Active
- 2009-02-25 JP JP2010549214A patent/JP5587798B2/ja not_active Expired - Fee Related
- 2009-02-25 WO PCT/IB2009/050752 patent/WO2009109873A1/en not_active Ceased
- 2009-02-25 CN CN2009801076626A patent/CN101959450B/zh active Active
- 2009-02-25 US US12/919,220 patent/US20100331782A1/en not_active Abandoned
-
2019
- 2019-04-19 US US16/388,909 patent/US11412985B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6564087B1 (en) * | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
| WO2006116163A2 (en) * | 2005-04-21 | 2006-11-02 | Biotelligent Inc. | Ultrasound guided tissue measurement system |
| US20070238997A1 (en) * | 2006-03-29 | 2007-10-11 | Estelle Camus | Ultrasound and fluorescence imaging |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5587798B2 (ja) | 2014-09-10 |
| US11412985B2 (en) | 2022-08-16 |
| EP2259716A1 (en) | 2010-12-15 |
| CN101959450A (zh) | 2011-01-26 |
| EP2259716B1 (en) | 2014-07-02 |
| JP2011512979A (ja) | 2011-04-28 |
| WO2009109873A1 (en) | 2009-09-11 |
| US20190313976A1 (en) | 2019-10-17 |
| US20100331782A1 (en) | 2010-12-30 |
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