CN1019495B - 嘧啶衍生物的制备方法 - Google Patents

嘧啶衍生物的制备方法

Info

Publication number
CN1019495B
CN1019495B CN87105512A CN87105512A CN1019495B CN 1019495 B CN1019495 B CN 1019495B CN 87105512 A CN87105512 A CN 87105512A CN 87105512 A CN87105512 A CN 87105512A CN 1019495 B CN1019495 B CN 1019495B
Authority
CN
China
Prior art keywords
formula
compound
dideoxy
prepare
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN87105512A
Other languages
English (en)
Chinese (zh)
Other versions
CN87105512A (zh
Inventor
罗伯特·威尔逊·兰伯特
约瑟夫·阿姆斯特朗·马丁
加雷夫·约翰·托马斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868619424A external-priority patent/GB8619424D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN87105512A publication Critical patent/CN87105512A/zh
Publication of CN1019495B publication Critical patent/CN1019495B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CN87105512A 1986-08-08 1987-08-07 嘧啶衍生物的制备方法 Expired CN1019495B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB86.19424 1986-08-08
GB868619424A GB8619424D0 (en) 1986-08-08 1986-08-08 Pyrimidine derivatives
GB87.10777 1987-05-07
GB878710777A GB8710777D0 (en) 1986-08-08 1987-05-07 Pyrimidine derivatives

Publications (2)

Publication Number Publication Date
CN87105512A CN87105512A (zh) 1988-02-17
CN1019495B true CN1019495B (zh) 1992-12-16

Family

ID=26291153

Family Applications (1)

Application Number Title Priority Date Filing Date
CN87105512A Expired CN1019495B (zh) 1986-08-08 1987-08-07 嘧啶衍生物的制备方法

Country Status (21)

Country Link
US (1) US4882316A (enExample)
EP (1) EP0255894B1 (enExample)
JP (1) JPH0643420B2 (enExample)
CN (1) CN1019495B (enExample)
AR (1) AR245729A1 (enExample)
AU (1) AU599403B2 (enExample)
CS (1) CS271476B2 (enExample)
DE (1) DE3782112D1 (enExample)
DK (1) DK363987A (enExample)
ES (1) ES2052522T3 (enExample)
FI (1) FI85864C (enExample)
GR (1) GR3006747T3 (enExample)
HU (1) HU196428B (enExample)
IE (1) IE60470B1 (enExample)
IL (1) IL83412A (enExample)
MC (1) MC1844A1 (enExample)
NO (1) NO169007C (enExample)
NZ (1) NZ221293A (enExample)
PH (1) PH24508A (enExample)
PT (1) PT85513B (enExample)
ZW (1) ZW14087A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3606634A1 (de) * 1986-02-28 1987-09-03 Mack Chem Pharm Isohexid-nucleoside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
NO170884C (no) * 1986-08-18 1992-12-23 Hoffmann La Roche Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater
US5495010A (en) * 1987-04-17 1996-02-27 The United States Of America As Represented By The Department Of Health And Human Services Acid stable purine dideoxynucleosides
US5459256A (en) * 1987-04-17 1995-10-17 The Government Of The United States Of America As Represented By The Department Of Health And Human Services Lipophilic, aminohydrolase-activated prodrugs
NZ232993A (en) * 1989-04-24 1992-10-28 Squibb & Sons Inc Purinyl and pyrimidinyl tetrahydrofurans
US5137724A (en) * 1990-05-23 1992-08-11 Stichting Rega Vzw Combinations of TS-inhibitors and viral TK-inhibitors in antiherpetic medicines
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
US5306722A (en) * 1992-09-02 1994-04-26 Bristol-Myers Squibb Company Thymidine derivatives and therapeutic method of use
JP4164247B2 (ja) * 2001-08-07 2008-10-15 独立行政法人科学技術振興機構 糖由来のゲル化剤
JP3660282B2 (ja) * 2001-08-20 2005-06-15 独立行政法人科学技術振興機構 ハイドロゲル化剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4000260A (en) * 1974-08-29 1976-12-28 Research Corporation Anti herpes simplex viral compounds and their synthesis
JPS5186483A (en) * 1975-01-29 1976-07-29 Ono Pharmaceutical Co 5**s chikan 2**5** jideokishi 55 furuororijinnoseizohoho
AU548712B2 (en) * 1983-05-23 1986-01-02 Taiho Pharmaceutical Co., Ltd. 2:-deoxy-5-substituted uridine derivatives
FR2548190B1 (fr) * 1983-07-01 1986-04-25 Centre Nat Rech Scient Procede de preparation de la sinefungine et de composes analogues
AU6836187A (en) * 1985-02-19 1987-07-15 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-trifluoromethyluridine derivatives and process for their preparation

Also Published As

Publication number Publication date
NO169007B (no) 1992-01-20
IE60470B1 (en) 1994-07-13
CS554387A2 (en) 1990-02-12
DE3782112D1 (de) 1992-11-12
FI873437A0 (fi) 1987-08-07
DK363987A (da) 1988-02-09
IL83412A0 (en) 1988-01-31
ES2052522T3 (es) 1994-07-16
JPS6344578A (ja) 1988-02-25
HU196428B (en) 1988-11-28
HUT45077A (en) 1988-05-30
AR245729A1 (es) 1994-02-28
EP0255894B1 (de) 1992-10-07
IL83412A (en) 1992-02-16
JPH0643420B2 (ja) 1994-06-08
CN87105512A (zh) 1988-02-17
PT85513A (en) 1987-09-01
AU599403B2 (en) 1990-07-19
ZW14087A1 (en) 1988-05-25
FI85864B (fi) 1992-02-28
PH24508A (en) 1990-07-18
GR3006747T3 (enExample) 1993-06-30
PT85513B (pt) 1990-05-31
EP0255894A2 (de) 1988-02-17
DK363987D0 (da) 1987-07-13
US4882316A (en) 1989-11-21
IE872124L (en) 1988-02-08
EP0255894A3 (en) 1988-06-01
NO872959L (no) 1988-02-09
NZ221293A (en) 1990-01-29
NO872959D0 (no) 1987-07-15
MC1844A1 (fr) 1988-09-30
CS271476B2 (en) 1990-10-12
FI85864C (fi) 1992-06-10
AU7653987A (en) 1988-02-11
FI873437A7 (fi) 1988-02-09
NO169007C (no) 1992-04-29

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GR01 Patent grant
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