CN101933992A

CN101933992A - Powder for treating oral ulcer

Info

Publication number: CN101933992A
Application number: CN2010102739062A
Authority: CN
Inventors: 徐道慧; 赵静
Original assignee: Individual
Current assignee: Individual
Priority date: 2010-09-07
Filing date: 2010-09-07
Publication date: 2011-01-05
Anticipated expiration: 2030-09-07
Also published as: CN101933992B

Abstract

The invention relates to powder for treating oral ulcer. The powder is prepared from the following raw materials in part by weight: 3 to 8 parts of medicinal cyathula root, 4 to 8 parts of tangerine peel, 3 to 6 parts of Chinese angelica, 2 to 5 parts of bupleurum, 3 to 6 parts of Chinese magnoliavine fruit, 0.1 to 1 part of borneol, 3 to 6 parts of chicken's gizzard-membrane, 2 to 6 parts of szechuan lovage rhizome, 1 to 4 parts of alum, 3 to 7 parts of liquoric root and 2 to 6 parts of angelica dahurlica. The powder of the invention has the advantages of having relatively obvious treatment effect for patients suffering from serious recurrent oral ulcer for a long time, fully improving immunologic function, enhancing the body resistance, killing ulcer viruses, curing ulcer and avoiding or eliminating recurrence for a relatively long time, along with simple composition, low cost and relatively ideal treatment effect.

Description

A kind of powder for the treatment of oral ulcer

Technical field

The present invention relates to field of medicaments, relate in particular to a kind of powder for the treatment of oral ulcer.

Background technology

Oral ulcer is called " aphtha " again, is the superficial ulcer that occurs on the oral mucosa, big I from the grain of rice to the Semen Glycines size, circular or oval, ulcer surface is recessed, congested on every side.Ulcer has characteristics such as periodicity, recurrent and self limiting, good sending out in lip, cheek, lingual margin etc.The cause of disease and mechanism of causing a disease are still indeterminate.Inducement may be local wound, psychentonia, food, medicine, hormonal readiness change and vitamin or trace element deficiency.Systemic disease, heredity, immunity and microorganism may play an important role in its generation, development.Treatment is mainly based on topical therapeutic, and severe patient needs whole body therapeutic.

At present, the cause of disease of oral ulcer and mechanism of causing a disease are still indeterminate.The inducement of oral ulcer may be local wound, psychentonia, food, medicine, hormonal readiness change and vitamin or trace element deficiency.Systemic disease, heredity, immunity and microorganism may play an important role in the generation of oral ulcer, development.Because etiology unknown, the diagnosis of oral ulcer is based on medical history and clinical manifestation fully, lacks to can be used as the lab index of making a definite diagnosis foundation.Oral ulcer is indicating that body has potential systemic disease, as the disease of gastrointestinal, blood and hormonal system, but most of clinically patient body health, the unsystematic disease.

Modern medicine thinks that recurrent oral ulceration at first has very confidential relation with immunity.The patient who has shows as immunodeficiency, and the patient who has then shows as autoimmune response, just because various factors, makes the normal immune system of human body, to autologous tissue's antigen, produces the immunity reflection, and causes disorganization and fall ill.Next is with heredity relation to be arranged, and in clinical, the morbidity of recurrent oral ulceration has tangible Inheritance tendency, and we usually see, father and mother one side or in many ways as if suffering from recurrent oral ulceration, so, their children are just easier to be ill than common people.In addition, the outbreak of recurrent oral ulceration, usually also relevant with some diseases or symptom; such as the digestive system disease gastric ulcer, duodenal ulcer, chronic or chronic persistent hepatitis; colitis etc., anemia in addition, monophagia; dyspepsia, diarrhoea, heating; do not have enough sleep; overtired, psychentonia, operating pressure is big, the change of menstrual cycle or the like.Along with one or more factors active, alternately, the overlapping immunity of organisms that just occurs descends, immunologic function disorder has also just caused the frequent outbreak of recurrent oral ulceration.

Chinese medicine has been widely used in the treatment oral ulcer at present.For example " surplus wheat oropharynx mixture ", this medicine is recurrence oral ulcer over-the-counter medications, and every bottled 100 milliliters, composition is Fructus Phyllanthi, Radix Rehmanniae etc., and adjuvant is a potassium sorbate, sucks a few minutes when taking usually to swallow better efficacy.But the exploitation for new medicine is never interrupted.

Summary of the invention

The purpose of this invention is to provide a kind of powder for the treatment of oral ulcer.

In order to realize purpose of the present invention, the invention provides a kind of powder for the treatment of oral ulcer, it is to be made by following materials by weight: 2～6 parts of Radix Cyathulae 3-8 part, 4～8 parts of Pericarpium Citri Reticulataes, 3～6 parts of Radix Angelicae Sinensis, 2～5 parts of Radix Bupleuri, 3～6 parts of Fructus Schisandrae Chinensis, 0.1～1 part of Borneolum Syntheticum, 3～6 parts of Endothelium Corneum Gigeriae Galli, 2～6 parts of Rhizoma Chuanxiongs, 1～4 part of Alumen, 3～7 parts in Radix Glycyrrhizae and the Radixs Angelicae Dahuricae.

Preferably, the powder of treatment oral ulcer of the present invention is to be made by following materials by weight: 4 parts of 5 parts of Radix Cyathulaes, 6 parts of Pericarpium Citri Reticulataes, 5 parts of Radix Angelicae Sinensis, 4 parts of Radix Bupleuri, 4 parts of Fructus Schisandrae Chinensis, 0.5 part of Borneolum Syntheticum, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Rhizoma Chuanxiongs, 2 parts of Alumens, 6 parts in Radix Glycyrrhizae and the Radixs Angelicae Dahuricae.

Can adopt method well known to those skilled in the art to carry out the preparation of powder.As required, can add various pharmaceutically acceptable carriers.Described carrier comprises diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant of pharmaceutical field routine etc.Powder of the present invention in the preparation, selectable filler has: starch, Icing Sugar, calcium phosphate, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hydroxypropyl emthylcellulose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.

Component of the present invention is simple, with low cost, therapeutic effect is more satisfactory, for the serious recurrent oral ulceration of long-term trouble apparent in view therapeutic effect is arranged, can improve immunologic function comprehensively, strengthen the human body resistance against diseases, thereby eliminate ulcer virus, make the ulcer recovery from illness, and can in the long time, not recur or not send out.

The specific embodiment

Further specify the present invention below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate the present invention rather than limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Except as otherwise noted, otherwise the percent among the present invention is percetage by weight.

Embodiment

Get Radix Cyathulae 50 grams, Pericarpium Citri Reticulatae 60 grams, Radix Angelicae Sinensis 50 grams, Radix Bupleuri 40 grams, Fructus Schisandrae Chinensis 40 grams, Borneolum Syntheticum 5 grams, Endothelium Corneum Gigeriae Galli 60 grams, Rhizoma Chuanxiong 40 grams, Alumen 20 grams, Radix Glycyrrhizae 60 grams and the Radix Angelicae Dahuricae 40 grams and fully mix, pulverize, cross 80 mesh sieves.Take by weighing Icing Sugar 30 grams then, cross 80 mesh sieves and above-mentioned raw materials and mix, promptly.Gained powder is divided into 100 bags.

Experimental example

Trial drug: the powder of the medicine of the present invention of experimental example 1

Using method: every day twice, each 1 bag evenly imposes on the ulcer.Two days courses of treatment, 3 courses of treatment of continuous administration.

Diagnostic criteria: 1, light-duty oral ulcer: the most common, account for 80%, general diameter 2-4mm, round or oval, clear on every side, isolated being dispersed in, number is few, and each 1～5 is not waited, good sending out in the relatively poor zone of keratinization degree, as lip cheek mucosa, the gum palatine that the keratinization degree is high is less, during outbreak ulcer have " recessed; red; Huang; feature bitterly ", i.e. ulcer concavity, substrate is not hard, periphery is with the congested blush band of about 1mm, and the surface is covered with light yellow pseudomembrane, and the causalgia sense is obvious, infecting serious time companion's submandibular lymph nodes swells and ache, heating generally continues 1-2 week, and the intermission is different in size, because of the thorn Severe Pain influences language, feed, mood, thus quality of life is had a negative impact; 2, heavy oral ulcer: ulcer is big and dark during outbreak, " like the crater " diameter 10-30mm, the dark tela submucosa that reaches is until the flesh layer, and periphery is red and swollen to swell, and the substrate of laying one's hand on is harder, but neat in edge is clear, normal single generation, stage of attack, can reach a month surplus even several months, and pain is heavier, more can stay cicatrix after, rare; 3, herpes sample oral ulcer: ulcer is little, and diameter 2mm can reach more than the dozens of and many, but symptoms such as companioned with headache, low grade fever, general malaise, regional nodes's enlargement are rare.

Criterion of therapeutical effect: pain disappears, the oral ulcer surface healing.

The present invention is through clinical observation case 50 examples, wherein male 25 examples, and 37 years old mean age, women 25 examples, 38 years old mean age, the result shows: wherein 24 patients cured in one day, and 15 patients cured in two days, and 5 patients cured in three days, and 6 patients cured in four days.Total effective rate 100%.

Untoward reaction: do not see obvious adverse reaction.

Follow up a case by regular visits to the recurrence situation: follow the tracks of for the patient and followed up a case by regular visits to 2 months, there is no recurrence.

Claims

1. powder for the treatment of oral ulcer, it is characterized in that it is to be made by following materials by weight: 2～6 parts of Radix Cyathulae 3-8 part, 4～8 parts of Pericarpium Citri Reticulataes, 3～6 parts of Radix Angelicae Sinensis, 2～5 parts of Radix Bupleuri, 3～6 parts of Fructus Schisandrae Chinensis, 0.1～1 part of Borneolum Syntheticum, 3～6 parts of Endothelium Corneum Gigeriae Galli, 2～6 parts of Rhizoma Chuanxiongs, 1～4 part of Alumen, 3～7 parts in Radix Glycyrrhizae and the Radixs Angelicae Dahuricae.

2. the powder of treatment oral ulcer according to claim 1, it is characterized in that it is to be made by following materials by weight: 4 parts of 5 parts of Radix Cyathulaes, 6 parts of Pericarpium Citri Reticulataes, 5 parts of Radix Angelicae Sinensis, 4 parts of Radix Bupleuri, 4 parts of Fructus Schisandrae Chinensis, 0.5 part of Borneolum Syntheticum, 6 parts of Endothelium Corneum Gigeriae Galli, 4 parts of Rhizoma Chuanxiongs, 2 parts of Alumens, 6 parts in Radix Glycyrrhizae and the Radixs Angelicae Dahuricae.