CN101932600B - 修饰的生长激素多肽 - Google Patents

修饰的生长激素多肽 Download PDF

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Publication number
CN101932600B
CN101932600B CN200880106595.1A CN200880106595A CN101932600B CN 101932600 B CN101932600 B CN 101932600B CN 200880106595 A CN200880106595 A CN 200880106595A CN 101932600 B CN101932600 B CN 101932600B
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CN
China
Prior art keywords
ser
leu
glu
thr
gly
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200880106595.1A
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English (en)
Chinese (zh)
Other versions
CN101932600A (zh
Inventor
彼得·阿蒂米克
理查德·A·罗斯
乔恩·塞耶斯
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Asterion Ltd
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Asterion Ltd
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Publication of CN101932600A publication Critical patent/CN101932600A/zh
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Publication of CN101932600B publication Critical patent/CN101932600B/zh
Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200880106595.1A 2007-10-10 2008-09-10 修饰的生长激素多肽 Expired - Fee Related CN101932600B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97901007P 2007-10-10 2007-10-10
US60/979,010 2007-10-10
GBGB0719818.7A GB0719818D0 (en) 2007-10-11 2007-10-11 Growth hormone fusion polypeptides
GB0719818.7 2007-10-11
PCT/GB2008/003056 WO2009047474A2 (en) 2007-10-10 2008-09-10 Modified growth hormone polypeptides

Publications (2)

Publication Number Publication Date
CN101932600A CN101932600A (zh) 2010-12-29
CN101932600B true CN101932600B (zh) 2014-05-28

Family

ID=38787949

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880106595.1A Expired - Fee Related CN101932600B (zh) 2007-10-10 2008-09-10 修饰的生长激素多肽

Country Status (17)

Country Link
US (2) US8273552B2 (enExample)
EP (2) EP2886553A1 (enExample)
JP (1) JP5697983B2 (enExample)
KR (1) KR20100067686A (enExample)
CN (1) CN101932600B (enExample)
AR (1) AR068038A1 (enExample)
AU (1) AU2008309386A1 (enExample)
BR (1) BRPI0818639A2 (enExample)
CA (1) CA2701369A1 (enExample)
DK (1) DK2209798T3 (enExample)
ES (1) ES2532600T3 (enExample)
GB (1) GB0719818D0 (enExample)
IL (1) IL203073A0 (enExample)
MX (1) MX2010003892A (enExample)
RU (1) RU2471808C2 (enExample)
TW (1) TW200918098A (enExample)
WO (1) WO2009047474A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0606946D0 (en) * 2006-04-06 2006-05-17 Asterion Ltd Polypeptide antagonist
GB201104285D0 (en) * 2011-03-15 2011-04-27 Asterion Ltd Modified receptor fusion proteins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096565A2 (en) * 2000-06-16 2001-12-20 Asterion Limited Binding agents: chimeric ligand/receptor proteins
WO2003070765A2 (en) * 2001-12-14 2003-08-28 Asterion Limited Growth hormone fusion protein
WO2004090135A2 (en) * 2003-04-09 2004-10-21 Asterion Limited Cytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH20A (fr) * 1888-12-05 Joseph Magnat Une pompe à bière automatique fonctionnant par la pression de l'eau
DE851925T1 (de) * 1995-09-21 2003-08-14 Genentech Inc., San Francisco Varianten des menschlichen wachstumshormons
GB0018891D0 (en) * 2000-08-01 2000-09-20 Novartis Ag Organic compounds
EP1456398B1 (en) * 2001-11-21 2011-05-11 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recovery of recombinant human parainfluenza virus type 1 (hpivi) from cdna
US20090221477A1 (en) * 2004-07-26 2009-09-03 Asterion Limited Linkers
GB0717985D0 (en) * 2007-07-20 2007-10-24 Asterion Ltd Growth hormone fusion proteins
JP2011512134A (ja) * 2008-02-19 2011-04-21 アステリオン・リミテッド 修飾リンカー

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096565A2 (en) * 2000-06-16 2001-12-20 Asterion Limited Binding agents: chimeric ligand/receptor proteins
WO2003070765A2 (en) * 2001-12-14 2003-08-28 Asterion Limited Growth hormone fusion protein
WO2004090135A2 (en) * 2003-04-09 2004-10-21 Asterion Limited Cytokine polypeptides and antibodies containing a signal sequence for the attachement of glycosylphosphatidylinositol

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Pegvisomant:a growth hormone receptor antagonist for the treatment of acromegaly;Parkinson C et al;《Growth Hormone and IGF Research》;20000401;第10卷;s119-s123 *
Tandem fusion of growth hormone and its G120R mutated antagonist retain biological activity and demonstrate prolonged plasma half-life;Pradhananga S L et al;《Growth Hormone and IGF Research》;20040401;第14卷(第2期);116 *

Also Published As

Publication number Publication date
RU2471808C2 (ru) 2013-01-10
AR068038A1 (es) 2009-10-28
RU2010103159A (ru) 2011-11-20
EP2886553A1 (en) 2015-06-24
US20120322735A1 (en) 2012-12-20
KR20100067686A (ko) 2010-06-21
TW200918098A (en) 2009-05-01
WO2009047474A2 (en) 2009-04-16
MX2010003892A (es) 2010-05-17
GB0719818D0 (en) 2007-11-21
DK2209798T3 (en) 2015-03-23
EP2209798B1 (en) 2014-12-31
ES2532600T3 (es) 2015-03-30
IL203073A0 (en) 2010-11-30
EP2209798A2 (en) 2010-07-28
BRPI0818639A2 (pt) 2015-04-07
WO2009047474A3 (en) 2010-09-02
JP5697983B2 (ja) 2015-04-08
CA2701369A1 (en) 2009-04-16
CN101932600A (zh) 2010-12-29
AU2008309386A1 (en) 2009-04-16
JP2011507487A (ja) 2011-03-10
US8273552B2 (en) 2012-09-25
US20100197589A1 (en) 2010-08-05

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Granted publication date: 20140528

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