TW200918098A - Modified growth hormone polypeptides - Google Patents

Info

Publication number

TW200918098A

TW200918098A TW097131758A TW97131758A TW200918098A TW 200918098 A TW200918098 A TW 200918098A TW 097131758 A TW097131758 A TW 097131758A TW 97131758 A TW97131758 A TW 97131758A TW 200918098 A TW200918098 A TW 200918098A

Authority

TW

Taiwan

Prior art keywords

leu

ser

seq

nucleic acid

acid sequence

Prior art date

2007-10-10

Links

• Espacenet
• Global Dossier
• Discuss

• 108010051696 Growth Hormone Proteins 0.000 title claims abstract description 92
• 102000018997 Growth Hormone Human genes 0.000 title claims abstract description 92
• 150000007523 nucleic acids Chemical class 0.000 claims abstract description 140
• 239000000122 growth hormone Substances 0.000 claims abstract description 89
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 72
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 72
• 239000000539 dimer Substances 0.000 claims abstract description 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 85
• 229920001184 polypeptide Polymers 0.000 claims description 75
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 75
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 74
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 68
• 239000000710 homodimer Substances 0.000 claims description 17
• 206010028980 Neoplasm Diseases 0.000 claims description 15
• 201000011510 cancer Diseases 0.000 claims description 13
• 239000008194 pharmaceutical composition Substances 0.000 claims description 13
• 230000000694 effects Effects 0.000 claims description 12
• 239000000203 mixture Substances 0.000 claims description 10
• 239000003814 drug Substances 0.000 claims description 9
• 238000002360 preparation method Methods 0.000 claims description 8
• 201000010099 disease Diseases 0.000 claims description 5
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
• 229940124013 Growth hormone receptor antagonist Drugs 0.000 claims description 4
• 206010060862 Prostate cancer Diseases 0.000 claims description 4
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
• 150000001875 compounds Chemical class 0.000 claims description 4
• 206010000599 Acromegaly Diseases 0.000 claims description 3
• 229940124597 therapeutic agent Drugs 0.000 claims description 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
• 230000003442 weekly effect Effects 0.000 claims description 2
• 238000004043 dyeing Methods 0.000 claims 1
• 230000009466 transformation Effects 0.000 claims 1
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• 238000000034 method Methods 0.000 abstract description 18
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• 238000011282 treatment Methods 0.000 abstract description 3
• 108010001064 glycyl-glycyl-glycyl-glycine Proteins 0.000 description 32
• 108010077245 asparaginyl-proline Proteins 0.000 description 30
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