CN101925596B - 用于治疗糖尿病的β-氨基酸衍生物 - Google Patents

用于治疗糖尿病的β-氨基酸衍生物 Download PDF

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Publication number
CN101925596B
CN101925596B CN200880125427.7A CN200880125427A CN101925596B CN 101925596 B CN101925596 B CN 101925596B CN 200880125427 A CN200880125427 A CN 200880125427A CN 101925596 B CN101925596 B CN 101925596B
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phenyl
dihydro
oxo
propionamide
pyridin
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Expired - Fee Related
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CN200880125427.7A
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Chinese (zh)
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CN101925596A (zh
Inventor
S·本德尔
L·T·布格多夫
U·埃姆德
N·拜尔
J·格莱茨
C·查隆
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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  • General Chemical & Material Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
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  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
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  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
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CN200880125427.7A 2008-01-24 2008-12-23 用于治疗糖尿病的β-氨基酸衍生物 Expired - Fee Related CN101925596B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08001305.5 2008-01-24
EP08001305 2008-01-24
PCT/EP2008/011099 WO2009092432A1 (en) 2008-01-24 2008-12-23 Beta-amino acid derivatives for treatment of diabetes

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Publication Number Publication Date
CN101925596A CN101925596A (zh) 2010-12-22
CN101925596B true CN101925596B (zh) 2014-05-28

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CN200880125427.7A Expired - Fee Related CN101925596B (zh) 2008-01-24 2008-12-23 用于治疗糖尿病的β-氨基酸衍生物

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Country Link
US (1) US8431602B2 (enExample)
EP (1) EP2231640B1 (enExample)
JP (1) JP5623914B2 (enExample)
KR (1) KR20100110367A (enExample)
CN (1) CN101925596B (enExample)
AR (1) AR070232A1 (enExample)
AU (1) AU2008348817B2 (enExample)
BR (1) BRPI0821827A2 (enExample)
CA (1) CA2712998A1 (enExample)
CY (1) CY1112919T1 (enExample)
DK (1) DK2231640T3 (enExample)
EA (1) EA017775B1 (enExample)
ES (1) ES2388475T3 (enExample)
HR (1) HRP20120510T1 (enExample)
IL (1) IL206904A0 (enExample)
MX (1) MX2010007926A (enExample)
PL (1) PL2231640T3 (enExample)
PT (1) PT2231640E (enExample)
SI (1) SI2231640T1 (enExample)
WO (1) WO2009092432A1 (enExample)
ZA (1) ZA201006002B (enExample)

Families Citing this family (10)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2017068412A1 (en) 2015-10-21 2017-04-27 Otsuka Pharmaceutical Co., Ltd. Benzolactam compounds as protein kinase inhibitors
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
WO2024229228A2 (en) * 2023-05-02 2024-11-07 The Rockefeller University 1-oxoisoindolin-2-yl amide activators of vcp and derivatives thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877200A (en) * 1993-07-02 1999-03-02 Celgene Corporation Cyclic amides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6482951B2 (en) * 2000-12-13 2002-11-19 Hoffmann-La Roche Inc. Isoindolin-1-one glucokinase activators
MXPA05003889A (es) * 2002-10-15 2005-06-22 Celgene Corp Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico.
KR20050090435A (ko) * 2002-12-30 2005-09-13 셀진 코포레이션 플루오로알콕시-치환된 1,3-디히드로-이소인돌릴 화합물 및그의 제약학적 용도
EP1811992A2 (en) * 2004-10-28 2007-08-01 Celgene Corporation Methods and compositions using pde4 modulators for treatment and management of central nervous system injury
EP2049518B1 (en) * 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877200A (en) * 1993-07-02 1999-03-02 Celgene Corporation Cyclic amides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor- αproduction inhibitors;Xavier Collin et.al.;《European Journal of Medicinal Chemistry》;20011231;第36卷;第641页Figure2，化合物20 *
Xavier Collin et.al..New anti-inflammatory N-pyridinyl(alkyl)phthalimides acting as tumour necrosis factor- αproduction inhibitors.《European Journal of Medicinal Chemistry》.2001,第36卷第641页Figure2,化合物20. *

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PT2231640E (pt) 2012-08-23
EA017775B1 (ru) 2013-03-29
HRP20120510T1 (hr) 2012-07-31
KR20100110367A (ko) 2010-10-12
ZA201006002B (en) 2011-04-28
BRPI0821827A2 (pt) 2015-06-16
EP2231640A1 (en) 2010-09-29
US8431602B2 (en) 2013-04-30
CY1112919T1 (el) 2016-04-13
MX2010007926A (es) 2010-08-09
EP2231640B1 (en) 2012-06-06
AU2008348817B2 (en) 2011-12-15
DK2231640T3 (da) 2012-07-16
ES2388475T3 (es) 2012-10-15
CN101925596A (zh) 2010-12-22
IL206904A0 (en) 2010-12-30
JP2011510029A (ja) 2011-03-31
WO2009092432A1 (en) 2009-07-30
SI2231640T1 (sl) 2012-09-28
US20100331346A1 (en) 2010-12-30
EA201001174A1 (ru) 2011-02-28
JP5623914B2 (ja) 2014-11-12
AR070232A1 (es) 2010-03-25
CA2712998A1 (en) 2009-07-30
AU2008348817A1 (en) 2009-07-30
PL2231640T3 (pl) 2012-09-28

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