CN101919852B - In vitro anti-insect spray for pets and preparation and using methods thereof - Google Patents
In vitro anti-insect spray for pets and preparation and using methods thereof Download PDFInfo
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- CN101919852B CN101919852B CN 201010108412 CN201010108412A CN101919852B CN 101919852 B CN101919852 B CN 101919852B CN 201010108412 CN201010108412 CN 201010108412 CN 201010108412 A CN201010108412 A CN 201010108412A CN 101919852 B CN101919852 B CN 101919852B
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Abstract
The invention discloses an in vitro anti-insect spray for pets and preparation and using methods thereof. The in vitro anti-insect spray for pets comprises 0.1 to 70 weight parts of insecticidal active ingredient and 15 to 170 weight parts of aid, wherein the insecticidal active ingredient is a mixture of rotenone and chlorantraniliprole. The in vitro anti-insect spray for pets is directly sprayed to the pets or ambient environment, and is used for killing external parasites which are parasitic on the pets or potential injurious insects in the ambient environment of the pets. The in vitro anti-insect spray for pets is convenient to use, and has obvious effect of preventing and controlling the external parasites of livestock or the pets, such as tick, flea, louse and mite.
Description
Technical field
The invention belongs to washing and insecticidal technology field, relate to a kind of the pet body epizoa is had prevent and the medicament of killing action, especially relate to a kind of vitro anti-insect spray for pets and preparation and application thereof.
Background technology
Along with the acceleration of Chinese society expanding economy and urbanization process, the upsurge of raising pets is surging forward in China city.Especially since 2004, the pet industry growth momentum of China is swift and violent.According to conservative estimation, the number of animals raised of pet dog only, the whole nation just has nearly 1,000 ten thousand.
According to investigations, have from consumer on the proportion of house pet, the accessed object of pet feeding Canis familiaris L. accounts for 36.8% of pet feeding family, the pet feeding cat account for 22.4% of pet feeding family, this shows that pet dog and cat are the main house pet types that China raises.
Because the hair of Canis familiaris L. and cat is abundant, Long Term Contact ground again, thereby be subject to the parasitic invasions such as louse, flea, demodicid mite, easily suffer from fungoid and bacteroidal dermatosis, as eczema, dermatitis, skin pruritus etc.Simultaneously, Canis familiaris L. and cat are all liked wide space, and the nature of strolling are arranged away, and it is movable that they miss potter the ground such as meadow, shrub, rubbish heap, and these places are concentrated infection districts of flea, cattle Ticks, louse, infectious disease.Spring, summer, warm, moist weather provided the chance of breeding for insecticides such as flea, tick, acarians.Secondly, in China big and medium-sized cities, the common people of 85% left and right stay in apartment type house, limited space, therefore in the park or the public recreating facility of residential quarter often can see owner and take a walk and stroll with loved house pet, these cats and Canis familiaris L., when kiss the earth or other infected article, or in the mutual process of playing, play may self with vermin and germina infection give other house pet.Owner when getting close to house pet, house pet also may be some sick and worm infect to the mankind, thereby the disease of formation infecting both domestic animals and human, as acarid, acarid is that house pet is easily carried the vermin of returning when playing outside, but immediate contagion is to the mankind.And cat scratch disease is to be propagated the bacterial infectious disease that Bartonellaehenselae causes between cat by cat flea, and the mankind can be by directly or indirectly contact is infected.
Vermiform mite, acaricide, Ticks, flea are the common several ectozoaes of cat, dog, and wherein vermiform mite is run the endobiosis life concurrently.These several parasites are not only caused direct infringement to pet body, but also are the communication medias of some disease pathogen.
At present, domestic and international main method to external parasite preventing and treatings such as cattle Ticks, flea, demodicid mites is that the chemosynthesis medicaments such as subcutaneous injection avilamycin and ivermectin etc., external use fluorine worm cyanogen, phoxim, coumafos, metrifonate are mixed with the bathing of house pet with medicament, medicine liquid spray and drop etc.These products have effect preferably to the part vermin of house pet, but price is all quite expensive, and part organophosphorus pesticide toxicity is higher, and are dangerous to house pet.
Summary of the invention
The object of the invention is to make up the deficiencies in the prior art, a kind of vitro anti-insect spray for pets is provided, safe and effective, especially first wait the common vermin of house pet to have the medicament of prevention and killing action to cattle Ticks, acarid, flea and louse, and easy to use, have no side effect.
Another object of the present invention is to provide the preparation method of described spray.
Purpose of the present invention is achieved by following technical proposals:
A kind of vitro anti-insect spray for pets is provided, according to the parts by weight meter, comprises other adjuvant of 0.1～70 part of active insecticidal components and 15～170 parts.
Described active insecticidal components is the mixture of rotenone (rotenone) and Rynaxypyr (chlorantraniliprole), mixed proportion is that the mass ratio of rotenone and Rynaxypyr is 1～40: 1～40, the mass ratio that preferred mixed proportion is rotenone and Rynaxypyr is 1～10: 1～10, and more preferred version is that the mass ratio of rotenone and ethiprole Rynaxypyr is 1～7: 1～7.
Described adjuvant comprises several in organic solvent, surfactant, antifreezing agent, anti-photodissociation agent, stabilizing agent, antioxidant or dispersant.The ratio of weight and number of described various adjuvant is:
Organic solvent: surfactant (or emulsifying agent): antifreezing agent: anti-photodissociation agent: stabilizing agent: antioxidant: dispersant=1～30 part: 2～20 parts: 1～10 part: 1～10 part: 1～10 part: 0.5～10 part: 10～80 parts.
Described organic solvent is selected from one or more of following substances: methanol, acetone, Ketohexamethylene, DMF, dimethyl sulfoxide, N-Methyl pyrrolidone, DMC dimethyl carbonate, isobutanol, isobutyl acetate, benzene, dimethylbenzene, naphthalane, gasoline, kerosene, machine oil, propylene glycol, propylene glycol, petroleum ether, Oleum Cinnamomi, eucalyptus oil, citronella oil, Oleum lavandula angustifolia, Sassafras oil, linalool, Fructus Coriandri oil or Semen Sinapis wet goods.
described emulsifying agent or surfactant are selected from one or more of following substances: NPE, or calcium dodecyl benzene sulfonate, or alkyl polyoxyethylene ether phosphate ester, or alkyl polyoxypropylene ether phosphate, or NPE phosphate ester, or fatty alcohol-polyoxyethylene ether series (AEO), or C12 alkyl (EO) 3 ether sodium sulfates (AES), or olefin sulfonic acid (AOS), or lauric acid amide of ethanol (6501), or styryl phenyl polyoxyethylene ether, or castor oil polyoxyethylene ether, or one or more mixture in the surfactant materials known altogether of this area staff.
Described antifreezing agent is selected from one or more of following substances: ethylene glycol, glycerol, sorbitol or ethanol.
Described anti-photodissociation agent is selected from one or more of following substances: amino this formic acid, Oleum Ricini, pyrogallic acid, citric acid, lignosulfonates, UV-P (2-(2 '-hydroxyl-5 '-aminomethyl phenyl) benzotriazole), BP-12 (are had another name called UV-531, Octabenzone,) or BP-3 (having another name called UV-9, ESCALOL 567).
Described stabilizing agent is selected from one or more of following substances: epoxidized soybean oil, pyrogallol, sodium sorbate, sodium benzoate, eugenol, citric acid, pyrogallic acid are sad, Oleum Ricini, salicylic acid, olive oil or epoxidized linseed.
Described antioxidant is selected from one or more of following compositions: vitamin E, vitamin C, beta-carotene, BHA (Butylated hydroxyanisole), BHT (2,6 ditertiary butyl p cresol), citric acid, methoxybenzene or P-hydroxybenzoic acid.
Described dispersant is selected from one or more of following compositions: ethanol, ethyl acetate or deionized water.
Preferably, vitro anti-insect spray for pets comprises each components of following parts by weight:
Active insecticidal components: organic solvent: surfactant: antifreezing agent: anti-photodissociation agent: stabilizing agent: antioxidant: dispersant=0.1～50 part: 1～30 part: 1～20 part: 1～10 part: 0.1～10 part: 1～10 part: 0.1～10 part: 10～80 parts.
The present invention provides the preparation method of described vitro anti-insect spray for pets simultaneously, first with the former powder of rotenone or crystal and the former medicinal solvent dissolving of Rynaxypyr, add surfactant to stir, add in proportion dispersant to mix, then add successively antifreezing agent, anti-photodissociation agent, stabilizing agent, antioxidant and dispersant, stir while adding evenly.
The using method of spray of the present invention is: hold this product during use, apart from 10～20 centimetres of house pet vertical dimensions, contrary tippy tea direction begins spray gently, to the whole house pet health of spraying covering.In the process of spray, note mobile containers, make the spray can the uniform fold animal skin, until animal skin tippy tea section humidity is gently grabbed fur and touched pet skin by spray.Perhaps directly spray of the present invention is sprayed on house pet life and movable environment.
The invention has the beneficial effects as follows:
Rotenone and Rynaxypyr are mixed and can increase drug effect any technology report is not yet arranged, more rotenone and ethiprole Rynaxypyr are not mixed and are applied to kill the ectozoic reports of pet body such as demodicid mite, Ticks, flea, louse as the effective active composition, the present invention studies discovery, adopt suitable proportioning, rotenone and ethiprole Rynaxypyr mixture are applied to house pet, the pet body epizoa had good toxic effect, both are mixed to use and can reduce dosage, increase drug effect; Widen the scope of application of medicament, delay pest resistance to insecticide and occur.
The outer parasite killing spray of pet body of the present invention selects the mixture of rotenone (rotenone) and low toxicity ultra high efficiency insecticide Rynaxypyr (chlorantraniliprole) to add that suitable adjuvant prepares, excellent to the ectozoic prevention of pet body such as cattle Ticks, acarid and killing effect, its preferred component proportioning is that the commercially available outer antiparasitic agents of the pet body with effective ingredient such as chlorine worm nitrile, Imidacloprid, ivermectins is more excellent to the ectozoic prevention of the pet bodies such as cattle Ticks and killing effect.Spray of the present invention is easy to use, and good disinsection effect is to people and pet safe.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment, but content of the present invention is not limited to this.
Embodiment 1
According to the parts by weight meter, prepare following each component:
A component: 4 parts of the former medicines of Rynaxypyr, 0.1 part, the former powder of rotenone or crystal, 5 parts of solvent methanols, 1 part of 3 parts+phenethyl of surfactant calcium dodecyl benzene sulfonate phenol polyethenoxy ether; 50 parts of dispersant ethanol.
B component: 5 parts of antifreeze glycols, 0.1 part of anti-photodissociation agent Oleum Ricini; 1 part of stabilizing agent citric acid; 1 part of antioxidant epoxidized soybean oil.
Also can depend on actual need adds essence, adds according to 0.5% of gross weight.
Preparation process is as follows:
(1) take each component by consumption;
(2) first with the former powder of rotenone or crystal and the former medicinal solvent dissolving of Rynaxypyr, add successively emulsifying agent, dispersant, stir to get A;
(3) antifreezing agent, anti-photodissociation agent, stabilizing agent, antioxidant and essence are added successively stir in A and get final product.
The using method of vitro anti-insect spray for pets of the present invention: hold this product during use, apart from 10～20 centimetres of house pet vertical dimensions, contrary tippy tea direction begins spray gently, to the whole house pet health of spraying covering.In the process of spray, note mobile containers, make the spray can the uniform fold animal skin, until animal skin tippy tea section humidity is gently grabbed fur and touched pet skin by spray.
Embodiment 2
According to the parts by weight meter, prepare following each component:
A component: 10 parts of the former medicines of Rynaxypyr, 1 part, the former powder of rotenone or crystal, 15 parts of solvent DMFs, 3 parts, 5 parts+triphenyl vinyl phenol of emulsifying agent triphenyl vinyl phenol polyoxyethylene poly-oxygen propylene aether polyoxyethylene polyoxypropylene ether; 40 parts of dispersant ethanol.
B component: 5 parts of antifreezing agent glycerol, anti-photodissociation agent UV-P (1 part of 2-(2 '-hydroxyl-5 '-aminomethyl phenyl); 1.5 parts of stabilizing agent citric acids; 0.5 part of antioxidant BHA (Butylated hydroxyanisole).
Also can depend on actual need adds essence, adds according to 0.5% of gross weight.Preparation method and using method are with embodiment 1.
Embodiment 3
According to the parts by weight meter, prepare following each component:
A component: 7 parts of the former medicines of Rynaxypyr, 1 part, the former powder of rotenone or crystal, 12 parts of solvent dimethyl sulfoxide, 8 parts of emulsifying agent fatty alcohol-polyoxyethylene ether (AEO7); 60 parts of dispersant ethanol.
The B component: 5 parts of antifreezing agent sorbitol, anti-photodissociation agent BP-12 (has another name called UV-531, chemical name: Octabenzone) 0.6 part; 3 parts, stabilizing agent olive oil; 0.1 part of antioxidant epoxidized linseed.
Also can depend on actual need adds essence, adds according to 0.3% of gross weight.Preparation method and using method are with embodiment 1.
Embodiment 4
According to the parts by weight meter, prepare following each component:
A component: 4 parts of the former medicines of Rynaxypyr, 1 part, the former powder of rotenone or crystal, 8 parts of solvent N-Methyl pyrrolidone, 7 parts of emulsifying agent styryl phenyl polyoxyethylene ether; 65 parts of dispersant ethanol.
The B component: 5 parts of antifreezing agent sorbitol, anti-photodissociation agent BP-12 (has another name called UV-531, chemical name: Octabenzone) 0.5 part; 3 parts of stabilizing agent sodium sorbates; 0.3 part of antioxidant eugenol.
Also can depend on actual need adds essence, adds according to 0.8% of gross weight.Preparation method and using method are with embodiment 1.
Embodiment 5
Take boophilus microplus as example, the present embodiment provides the different proportionings of rotenone and Rynaxypyr to the parasitic killing effect of house pet, and concrete outcome is as shown in table 1.
Test method adopts the medicine infusion process of standard.First determine general concentration range through trial test, all medicines all half-and-half are diluted to the variable concentrations gradient with distilled water, do not suck blood 10 of young Tickss of every group of boophilus microplus in test, 3 repetitions of every processing.Draw the 1ml medicine and add boophilus microplus not suck blood in young Ticks, dipping 5s-10min with the medicine sucking-off, wipes away the medicinal liquid of dried Ticks body surface with filter paper, and being transferred to the bottom has in the drying basin of water, room temperature, and relative humidity remains on 80-85%.After 24h, observe its death condition.Be provided with distilled water and Normal group in test.If the mortality rate of matched group is at 5-20% Abbott formula correction.With the dead boophilus microplus of the following program judgement young Ticks of not sucking blood: the one, direct observation, each limb inertia of boophilus microplus; The 2nd, under anatomical lens, cannot see each limb of boophilus microplus movable; The 3rd, slightly contact with toothpick under anatomical lens, also cannot see each limb of boophilus microplus movable.Improved mortality formula:
The killing effect of table 1 rotenone proportionings different from Rynaxypyr to the cattle Ticks
A represents Rynaxypyr; B represents rotenone
Table 2 toxicity test result of calculation
A represents Rynaxypyr; B represents rotenone
With 30 fleas (adult of cat flea), 5 kittens (wherein in contrast) with it in parasitism respectively.After one day, evenly be sprayed on it kitten with little aerosol apparatus with the medicament in embodiment 1,2,3 and 4, until kitten hair with it moistening till, the kitten of contrast is only sprayed clear water with it, sprayed rear 1 day and 3 days, and by catching the parasitic flea number of flea comb counting, calculated prevention effect.Calculate control rate according to following formula, result is according to following standard evaluation.
| Evaluation criterion | Control rate (%) |
| A | 100 |
| B | 99-90 |
| C | 89-80 |
| D | 79-50 |
| E | ＜50 |
Experimental result shows, the prevention effect of the embodiment of the present invention 1,2,3 and 4 pairs of kitten epizoite insects all reaches A.
Claims (5)
1. one kind is applicable to prevent and treat the ectozoic parasite killing host of pet body, it is characterized in that for Rynaxypyr and rotenone be that 10:1～1:3 is mixed with the mixture that obtains according to mass ratio.
2. be applicable to according to claim 1 prevent and treat the ectozoic parasite killing host of pet body, it is characterized in that for Rynaxypyr and rotenone be that 4:0.1,10:1,7:1,5:1,4:1,3:1,1:1 or 1:3 are mixed with the mixture that obtains according to mass ratio.
3. vitro anti-insect spray for pets is characterized in that comprising each component of following ratio of weight and number:
The described parasite killing host of claim 1 or 2: organic solvent: surfactant: antifreezing agent: anti-photodissociation agent: stabilizing agent: antioxidant: dispersant=0.1～50 part: 1～30 part: 1～20 part: 1～10 part: 0.1～10 part: 1～10 part: 0.1～10 part: 10～80 parts;
Described solvent is selected from one or more of following substances: methanol, DMF, dimethyl sulfoxide or N-Methyl pyrrolidone;
Described surfactant is selected from one or more of following substances: calcium dodecyl benzene sulfonate, fatty alcohol-polyoxyethylene ether AEO7 or styryl phenyl polyoxyethylene ether;
Described antifreezing agent is selected from one or more of following substances: ethylene glycol, glycerol or sorbitol;
Described anti-photodissociation agent is selected from one or more of following compositions: Oleum Ricini, UV-P or BP-12;
Described stabilizing agent is selected from one or more of following substances: citric acid or olive oil;
Described antioxidant is selected from one or more of following substances: epoxidized soybean oil, epoxidized linseed, Butylated hydroxyanisole or eugenol;
Described dispersant is ethanol.
4. the preparation method of the described vitro anti-insect spray for pets of claim 3, it is characterized in that the former powder of rotenone or crystal and the former medicinal solvent dissolving of Rynaxypyr, add surfactant to stir, add in proportion dispersant to mix, then add successively antifreezing agent, anti-photodissociation agent, stabilizing agent, antioxidant and/or dispersant, stir while adding evenly.
5. the using method of the described vitro anti-insect spray for pets of claim 3, it is characterized in that 10～20 centimetres of distance house pet vertical dimensions, contrary tippy tea direction begins to spray described spray gently, to spray uniform fold animal skin, until animal skin tippy tea section humidity is gently grabbed fur and is touched pet skin by spray; Perhaps directly spray of the present invention is sprayed on house pet life and movable environment.
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101856027B (en) * | 2010-06-02 | 2013-02-20 | 扬州大学 | Pesticide preparation for controlling diamond back moth and other vegetable insect pests |
| CN102550573B (en) * | 2012-01-30 | 2013-10-30 | 华南理工大学 | Chlorantraniliprole and rotenone compound suspending agent and its preparation method |
| GB201404505D0 (en) * | 2013-09-06 | 2014-04-30 | Mars Inc | Oral anti-parasitic composition |
| CN104398529A (en) * | 2014-10-27 | 2015-03-11 | 武汉中博绿亚生物科技有限公司 | Washing agent for assisting to kill pet body surface mites and preparation method thereof |
| CN105412004B (en) * | 2015-12-03 | 2019-01-08 | 湖北美天生物科技股份有限公司 | It is a kind of for treating and protecting the antiparasitic composition of non-food stuff animal |
| CN105688168A (en) * | 2016-03-19 | 2016-06-22 | 上海申亚动物保健品阜阳有限公司 | Pet all-in-one insect expelling spray and preparation method thereof |
| CN113367118A (en) * | 2021-05-14 | 2021-09-10 | 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) | Application of Chinese cinnamon essential oil |
| CN115720902A (en) * | 2021-09-01 | 2023-03-03 | 郑州赛科药业科技有限公司 | Traditional Chinese medicine spray for treating ectoparasites of pets |
| CN117771182B (en) * | 2024-02-22 | 2024-05-31 | 中国农业大学 | External SU3327 spray for pets and preparation method and application thereof |
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| CN101557710A (en) * | 2006-12-14 | 2009-10-14 | 石原产业株式会社 | Pesticidal compositions |
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| CN101557710A (en) * | 2006-12-14 | 2009-10-14 | 石原产业株式会社 | Pesticidal compositions |
Non-Patent Citations (1)
| Title |
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| 无.病毒杀虫剂的应用.《湖北植保》.2009,(第114期),66-67. * |
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