CN101918445B - 用于早期妊娠诊断的组合物和方法 - Google Patents

用于早期妊娠诊断的组合物和方法 Download PDF

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Publication number
CN101918445B
CN101918445B CN200880124722.0A CN200880124722A CN101918445B CN 101918445 B CN101918445 B CN 101918445B CN 200880124722 A CN200880124722 A CN 200880124722A CN 101918445 B CN101918445 B CN 101918445B
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China
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antibody
pag
pregnancy
seq
sample
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Chinese (zh)
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CN101918445A (zh
Inventor
N·马赛亚拉甘
R·M·罗伯斯
M·F·麦克格拉斯
J·格林
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University of Missouri Columbia
Monsanto Co
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University of Missouri Columbia
Monsanto Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/471—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN200880124722.0A 2007-12-13 2008-12-12 用于早期妊娠诊断的组合物和方法 Active CN101918445B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1360307P 2007-12-13 2007-12-13
US61/013,603 2007-12-13
PCT/US2008/086674 WO2009076632A1 (en) 2007-12-13 2008-12-12 Compositions and methods for early pregnancy diagnosis

Publications (2)

Publication Number Publication Date
CN101918445A CN101918445A (zh) 2010-12-15
CN101918445B true CN101918445B (zh) 2014-05-14

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US (1) US8431349B2 (enExample)
EP (1) EP2225274B1 (enExample)
JP (1) JP5679818B2 (enExample)
KR (1) KR101637613B1 (enExample)
CN (1) CN101918445B (enExample)
AU (1) AU2008334976B2 (enExample)
BR (1) BRPI0820885B8 (enExample)
CA (1) CA2709305C (enExample)
CO (1) CO6280567A2 (enExample)
DK (1) DK2225274T3 (enExample)
ES (1) ES2623459T3 (enExample)
HU (1) HUE034401T2 (enExample)
NZ (1) NZ586100A (enExample)
WO (1) WO2009076632A1 (enExample)
ZA (1) ZA201004487B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192946B2 (en) 2008-04-10 2012-06-05 The Curators Of The University Of Missouri Assays for detecting pregnancy-associated glycoproteins
US8541187B2 (en) 2011-03-01 2013-09-24 Bio Tracking, LLC Systems and methods for detecting animal pregnancy
US9241977B2 (en) * 2013-03-01 2016-01-26 Arthrex, Inc. Enhanced anabolic cytokine production and delivery system
CN105424937B (zh) * 2015-10-05 2017-11-21 华中农业大学 一种猴早期妊娠检测的孕酮胶体金免疫层析试纸条
CN107219368B (zh) * 2017-06-06 2019-02-26 山西农业大学 奶牛pag1检测试纸条及其制备方法
CN107853241A (zh) * 2017-10-16 2018-03-30 广西壮族自治区水牛研究所 一种提高水牛配种效率的方法
KR102189893B1 (ko) * 2017-11-15 2020-12-11 (주)에스엘에스바이오 bPAG1에 특이적으로 결합하는 항체 및 이의 용도
CN108314732A (zh) * 2018-01-15 2018-07-24 妊达（北京）生物技术有限公司 一种抗牛早孕因子单克隆抗体细胞株单克隆抗体的制备方法
CN109295003B (zh) * 2018-09-10 2022-03-04 吉林医药学院 产生牛妊娠相关糖蛋白特异性单克隆抗体的小鼠杂交瘤细胞株、单克隆抗体、试剂盒及检测
CN111500583B (zh) * 2020-03-04 2021-09-10 新疆农垦科学院 特异性识别牛妊娠相关糖蛋白4的核酸适配体及其应用
CA3202429A1 (en) * 2020-12-20 2022-06-23 Regeneron Pharmaceuticals, Inc. Methods for identification of scrambled disulfides in biomolecules
CN113960025A (zh) * 2021-10-12 2022-01-21 北京农学院 一种奶牛早期妊娠的检测方法
KR20230065047A (ko) * 2021-11-04 2023-05-11 주식회사 나노바이오라이프 소 임신 진단 항체와 이를 이용한 조기 임신 진단키트 개발
CN114672464B (zh) * 2022-03-31 2024-10-01 吴峰 一种分泌抗牛妊娠相关糖蛋白单克隆抗体的杂交瘤细胞、单克隆抗体及应用
CN117820434B (zh) * 2023-12-31 2024-11-19 武汉优恩生物科技有限公司 牛羊妊娠相关糖蛋白的多肽抗原及应用
CN119285785B (zh) * 2024-09-26 2025-04-18 武汉奥科博泰生物科技有限公司 一种抗d-二聚体单克隆抗体及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050100975A1 (en) * 1998-03-20 2005-05-12 Roberts Robert M. Compositions and methods for early pregnancy diagnosis

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208479A (en) 1977-07-14 1980-06-17 Syva Company Label modified immunoassays
US4271140A (en) 1978-01-23 1981-06-02 Baxter Travenol Laboratories, Inc. Method and composition for double receptor, specific binding assays
US4895804A (en) 1984-07-06 1990-01-23 University Of Minnesota Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle
US4755460A (en) 1984-07-06 1988-07-05 The Regents Of The Univ. Of Minnesota Bovine antigen glycoprotein, related antibody, and use in detection of pregnancy in cattle
DE3682088D1 (de) * 1985-03-18 1991-11-28 Mitsubishi Petrochemical Co Verfahren zur herstellung von wasserabsorbierenden polymeren.
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
DE19733505A1 (de) 1997-08-01 1999-02-04 Knoll Ag Schnell wirksames Analgeticum
IL137601A0 (en) 1998-02-02 2001-07-24 Concepto Diagnostics Inc Method and apparatus for detecting conception in animals
BR0210474A (pt) * 2001-06-19 2004-08-10 Idaho Res Foundation Determinação do estado de prenhez
NZ531818A (en) * 2001-09-25 2005-10-28 Fujisawa Pharmaceutical Co Recombinant anti-osteopontin antibody and use in the treatment of autoimmune diseases such as rheumatoid arthritis and osteoarthritis
WO2003028582A2 (en) 2001-09-28 2003-04-10 Aspenbio, Inc. Bovine pregnancy test
CA2467904C (en) 2001-11-20 2009-04-07 The Curators Of The University Of Missouri Compositions and methods for accurate early pregnancy diagnosis
US20080110537A1 (en) * 2004-09-29 2008-05-15 Koninklijke Philips Electronics, N.V. Smart Handbag
US8192946B2 (en) 2008-04-10 2012-06-05 The Curators Of The University Of Missouri Assays for detecting pregnancy-associated glycoproteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050100975A1 (en) * 1998-03-20 2005-05-12 Roberts Robert M. Compositions and methods for early pregnancy diagnosis
US20070166773A1 (en) * 1998-03-20 2007-07-19 Roberts Robert M Compositions and methods for early pregnancy diagnosis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
The establishment of an ELISA for the detection of pregnancy-associated glycoproteins (PAGs) in the serum of pregnant cows and heifers;Jonathan A. Green et al.;《Theriogenology》;20050315;第63卷(第5期);1481-1503 *

Also Published As

Publication number Publication date
EP2225274B1 (en) 2017-02-15
HUE034401T2 (en) 2018-02-28
JP2011507810A (ja) 2011-03-10
ZA201004487B (en) 2011-04-28
CA2709305A1 (en) 2009-06-18
BRPI0820885B8 (pt) 2021-03-02
KR101637613B1 (ko) 2016-07-07
BRPI0820885A2 (pt) 2015-07-21
NZ586100A (en) 2012-07-27
HK1148760A1 (en) 2011-09-16
KR20100110818A (ko) 2010-10-13
WO2009076632A1 (en) 2009-06-18
JP5679818B2 (ja) 2015-03-04
CO6280567A2 (es) 2011-05-20
AU2008334976A1 (en) 2009-06-18
ES2623459T3 (es) 2017-07-11
US20110076705A1 (en) 2011-03-31
AU2008334976B2 (en) 2013-05-23
EP2225274A1 (en) 2010-09-08
CN101918445A (zh) 2010-12-15
US8431349B2 (en) 2013-04-30
CA2709305C (en) 2017-03-07
DK2225274T3 (en) 2017-05-01

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