CN101915957B - 实施分析反应的基材 - Google Patents
实施分析反应的基材 Download PDFInfo
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- CN101915957B CN101915957B CN2010102565357A CN201010256535A CN101915957B CN 101915957 B CN101915957 B CN 101915957B CN 2010102565357 A CN2010102565357 A CN 2010102565357A CN 201010256535 A CN201010256535 A CN 201010256535A CN 101915957 B CN101915957 B CN 101915957B
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Images
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/10—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/7709—Distributed reagent, e.g. over length of guide
- G01N2021/7713—Distributed reagent, e.g. over length of guide in core
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Optical Integrated Circuits (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81286306P | 2006-06-12 | 2006-06-12 | |
| US60/812,863 | 2006-06-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800218264A Division CN101467082B (zh) | 2006-06-12 | 2007-06-11 | 实施分析反应的基材 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101915957A CN101915957A (zh) | 2010-12-15 |
| CN101915957B true CN101915957B (zh) | 2012-12-12 |
Family
ID=38834243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010102565357A Active CN101915957B (zh) | 2006-06-12 | 2007-06-11 | 实施分析反应的基材 |
| CN2007800218264A Expired - Fee Related CN101467082B (zh) | 2006-06-12 | 2007-06-11 | 实施分析反应的基材 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007800218264A Expired - Fee Related CN101467082B (zh) | 2006-06-12 | 2007-06-11 | 实施分析反应的基材 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7486865B2 (https=) |
| EP (2) | EP2027253A4 (https=) |
| JP (1) | JP2009539411A (https=) |
| CN (2) | CN101915957B (https=) |
| AU (1) | AU2007261114B2 (https=) |
| CA (1) | CA2654470C (https=) |
| WO (1) | WO2007149724A2 (https=) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1979079A4 (en) | 2006-02-03 | 2012-11-28 | Integenx Inc | MICROFLUIDIC DEVICES |
| US8975216B2 (en) * | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| CN101915957B (zh) * | 2006-06-12 | 2012-12-12 | 加利福尼亚太平洋生物科学公司 | 实施分析反应的基材 |
| US9176062B2 (en) | 2006-12-21 | 2015-11-03 | Koninklijke Philips N.V. | Aperture biosensor with trenches |
| DE102007016699A1 (de) * | 2007-04-04 | 2008-10-09 | Synentec Gmbh | Biochip für die Fluoreszenzanalyse von einzelnen Transportern |
| US20110250402A1 (en) * | 2008-06-02 | 2011-10-13 | Applied Biosystems, Llc | Localization of near-field resonances in bowtie antennae: influence of adhesion layers |
| EP2362947B1 (en) | 2008-09-30 | 2017-05-10 | Pacific Biosciences of California, Inc. | Ultra-high multiplex analytical systems and methods |
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| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| US9394567B2 (en) | 2008-11-07 | 2016-07-19 | Adaptive Biotechnologies Corporation | Detection and quantification of sample contamination in immune repertoire analysis |
| US8628927B2 (en) | 2008-11-07 | 2014-01-14 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| EP2364368B1 (en) | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US9528160B2 (en) | 2008-11-07 | 2016-12-27 | Adaptive Biotechnolgies Corp. | Rare clonotypes and uses thereof |
| ES2726702T3 (es) | 2009-01-15 | 2019-10-08 | Adaptive Biotechnologies Corp | Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales |
| US9778188B2 (en) * | 2009-03-11 | 2017-10-03 | Industrial Technology Research Institute | Apparatus and method for detection and discrimination molecular object |
| WO2010151416A1 (en) | 2009-06-25 | 2010-12-29 | Fred Hutchinson Cancer Research Center | Method of measuring adaptive immunity |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| US8367159B2 (en) * | 2009-09-11 | 2013-02-05 | Pacific Biosciences Of California, Inc. | Methods for producing ZMWs with islands of functionality |
| US8906670B2 (en) | 2009-09-11 | 2014-12-09 | Pacific Bioscience Of California, Inc. | Zero-mode waveguides with non-reflecting walls |
| EP3460458B1 (en) | 2010-02-19 | 2021-08-11 | Pacific Biosciences of California, Inc. | A method for nucleic acid sequencing |
| US8994946B2 (en) | 2010-02-19 | 2015-03-31 | Pacific Biosciences Of California, Inc. | Integrated analytical system and method |
| US9482615B2 (en) | 2010-03-15 | 2016-11-01 | Industrial Technology Research Institute | Single-molecule detection system and methods |
| US9670243B2 (en) | 2010-06-02 | 2017-06-06 | Industrial Technology Research Institute | Compositions and methods for sequencing nucleic acids |
| US8865077B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| US8865078B2 (en) | 2010-06-11 | 2014-10-21 | Industrial Technology Research Institute | Apparatus for single-molecule detection |
| EP2606154B1 (en) | 2010-08-20 | 2019-09-25 | Integenx Inc. | Integrated analysis system |
| CN103502463B (zh) | 2010-12-27 | 2016-03-16 | 艾比斯生物科学公司 | 核酸样品的制备方法及组合物 |
| EP2689028B1 (en) | 2011-03-23 | 2017-08-30 | Pacific Biosciences Of California, Inc. | Isolation of polymerase-nucleic acid complexes and loading onto substrates |
| US9670538B2 (en) | 2011-08-05 | 2017-06-06 | Ibis Biosciences, Inc. | Nucleic acid sequencing by electrochemical detection |
| US10385475B2 (en) | 2011-09-12 | 2019-08-20 | Adaptive Biotechnologies Corp. | Random array sequencing of low-complexity libraries |
| US10865440B2 (en) | 2011-10-21 | 2020-12-15 | IntegenX, Inc. | Sample preparation, processing and analysis systems |
| US20150136604A1 (en) | 2011-10-21 | 2015-05-21 | Integenx Inc. | Sample preparation, processing and analysis systems |
| EP2768982A4 (en) | 2011-10-21 | 2015-06-03 | Adaptive Biotechnologies Corp | QUANTIFICATION OF ADAPTIVE IMMUNOCELL GENOMES IN A COMPLEX MIX OF CELLS |
| US9267917B2 (en) | 2011-11-04 | 2016-02-23 | Pacific Biosciences Of California, Inc. | Nanopores in zero mode waveguides |
| US9824179B2 (en) | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| US9499865B2 (en) | 2011-12-13 | 2016-11-22 | Adaptive Biotechnologies Corp. | Detection and measurement of tissue-infiltrating lymphocytes |
| WO2013096819A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Macromolecule positioning by electrical potential |
| US9803231B2 (en) | 2011-12-29 | 2017-10-31 | Ibis Biosciences, Inc. | Macromolecule delivery to nanowells |
| WO2013101741A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Molecular, Inc. | Channels with cross-sectional thermal gradients |
| EP2802666B1 (en) | 2012-01-13 | 2018-09-19 | Data2Bio | Genotyping by next-generation sequencing |
| US9238836B2 (en) | 2012-03-30 | 2016-01-19 | Pacific Biosciences Of California, Inc. | Methods and compositions for sequencing modified nucleic acids |
| US9062091B2 (en) | 2012-02-15 | 2015-06-23 | Pacific Biosciences Of California, Inc. | Polymerase enzyme substrates with protein shield |
| EP3372694A1 (en) | 2012-03-05 | 2018-09-12 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
| EP2844774B1 (en) | 2012-05-02 | 2018-07-18 | Ibis Biosciences, Inc. | Dna sequencing |
| EP3783111A1 (en) | 2012-05-02 | 2021-02-24 | Ibis Biosciences, Inc. | Dna sequencing |
| US10202642B2 (en) | 2012-05-02 | 2019-02-12 | Ibis Biosciences, Inc. | DNA sequencing |
| HUE029357T2 (en) | 2012-05-08 | 2017-02-28 | Adaptive Biotechnologies Corp | Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions |
| US9372308B1 (en) | 2012-06-17 | 2016-06-21 | Pacific Biosciences Of California, Inc. | Arrays of integrated analytical devices and methods for production |
| US9551030B2 (en) | 2012-06-17 | 2017-01-24 | Pacific Biosciences Of California, Inc. | Filter architecture for analytical devices |
| EP3330384B1 (en) | 2012-10-01 | 2019-09-25 | Adaptive Biotechnologies Corporation | Immunocompetence assessment by adaptive immune receptor diversity and clonality characterization |
| EP2909343B1 (en) | 2012-10-16 | 2018-10-10 | Abbott Molecular Inc. | Methods to sequence a nucleic acid |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| EP2936222B1 (en) | 2012-12-18 | 2019-07-03 | Pacific Biosciences Of California, Inc. | An optical analytical device |
| US9624540B2 (en) | 2013-02-22 | 2017-04-18 | Pacific Biosciences Of California, Inc. | Integrated illumination of optical analytical devices |
| US10428379B2 (en) | 2013-03-15 | 2019-10-01 | Ibis Biosciences, Inc. | Nucleotide analogs for sequencing |
| US9581550B2 (en) | 2013-05-31 | 2017-02-28 | Pacific Biosciences Of California | Analytical devices having compact lens train arrays |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| ES2764096T3 (es) | 2013-08-19 | 2020-06-02 | Abbott Molecular Inc | Bibliotecas de secuenciación de próxima generación |
| CN114471756B (zh) | 2013-11-18 | 2024-04-16 | 尹特根埃克斯有限公司 | 用于样本分析的卡盒和仪器 |
| US10768181B2 (en) | 2013-12-17 | 2020-09-08 | The Brigham And Women's Hospital, Inc. | Detection of an antibody against a pathogen |
| US12183436B2 (en) | 2013-12-18 | 2024-12-31 | Pacific Biosciences Of California, Inc. | String graph assembly for polyploid genomes |
| US9540688B2 (en) | 2014-02-19 | 2017-01-10 | Personal Genomics, Inc. | Real-time sequencing method for single molecule |
| WO2015134787A2 (en) | 2014-03-05 | 2015-09-11 | Adaptive Biotechnologies Corporation | Methods using randomer-containing synthetic molecules |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| WO2015179098A1 (en) | 2014-05-21 | 2015-11-26 | Integenx Inc. | Fluidic cartridge with valve mechanism |
| WO2015200541A1 (en) | 2014-06-24 | 2015-12-30 | Bio-Rad Laboratories, Inc. | Digital pcr barcoding |
| ES2753573T3 (es) | 2014-06-27 | 2020-04-13 | Abbott Lab | Composiciones y métodos para detectar pegivirus humano 2 (HPGV-2) |
| TWI692633B (zh) | 2014-08-27 | 2020-05-01 | 美商加州太平洋生物科學公司 | 整合式分析裝置之陣列 |
| CN107002293B (zh) | 2014-09-17 | 2020-12-08 | 艾比斯生物科学公司 | 使用脉冲读数光学的通过合成测序 |
| CN107106983B (zh) | 2014-10-22 | 2021-04-16 | 尹特根埃克斯有限公司 | 用于样品制备、处理和分析的系统和方法 |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| AU2015353581A1 (en) | 2014-11-25 | 2017-06-15 | Adaptive Biotechnologies Corporation | Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing |
| US10783984B2 (en) | 2014-12-18 | 2020-09-22 | Pacific Biosciences Of California, Inc. | De novo diploid genome assembly and haplotype sequence reconstruction |
| CN106148969A (zh) * | 2014-12-29 | 2016-11-23 | 厦门火炬特种金属材料有限公司 | 一种镁合金牺牲阳极电流效率快速检测装置和方法 |
| US10302972B2 (en) | 2015-01-23 | 2019-05-28 | Pacific Biosciences Of California, Inc. | Waveguide transmission |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| EP3271762B1 (en) | 2015-03-16 | 2023-01-04 | Pacific Biosciences of California, Inc. | Analytical system comprising integrated devices and systems for free-space optical coupling |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| EP3292220B1 (en) | 2015-05-07 | 2022-07-13 | Pacific Biosciences of California, Inc. | Multiprocessor pipeline architecture |
| EP4425153A3 (en) | 2015-06-12 | 2024-11-20 | Pacific Biosciences Of California, Inc. | Integrated target waveguide devices and systems for optical coupling |
| US10280411B2 (en) | 2015-10-27 | 2019-05-07 | Pacific Biosciences of California, In.c | Methods, systems, and reagents for direct RNA sequencing |
| TWI794145B (zh) | 2015-10-28 | 2023-03-01 | 美商加州太平洋生物科學公司 | 包含整合性帶通濾波器之光學裝置陣列 |
| EP3377656B1 (en) | 2015-11-18 | 2025-07-02 | Pacific Biosciences of California, Inc. | Loading nucleic acids onto substrates |
| WO2017087696A1 (en) | 2015-11-18 | 2017-05-26 | Pacific Biosciences Of California, Inc. | Methods and compositions for loading of polymerase complexes |
| CN108431223A (zh) | 2016-01-08 | 2018-08-21 | 生物辐射实验室股份有限公司 | 每液滴分辨率下的多个珠 |
| US10544457B2 (en) | 2016-06-14 | 2020-01-28 | Pacific Biosciences Of California, Inc. | Methods and compositions for enriching compositions for polymerase enzyme complexes |
| US10711300B2 (en) | 2016-07-22 | 2020-07-14 | Pacific Biosciences Of California, Inc. | Methods and compositions for delivery of molecules and complexes to reaction sites |
| US11543417B2 (en) | 2016-08-29 | 2023-01-03 | Oslo Universitetssykehus Hf | ChIP-seq assays |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CN110139932B (zh) | 2016-12-19 | 2024-05-17 | 生物辐射实验室股份有限公司 | 液滴加标的相邻性保留的标签化dna |
| US10468736B2 (en) | 2017-02-08 | 2019-11-05 | Aptiv Technologies Limited | Radar assembly with ultra wide band waveguide to substrate integrated waveguide transition |
| US11186862B2 (en) | 2017-06-20 | 2021-11-30 | Bio-Rad Laboratories, Inc. | MDA using bead oligonucleotide |
| WO2019089959A1 (en) | 2017-11-02 | 2019-05-09 | Bio-Rad Laboratories, Inc. | Transposase-based genomic analysis |
| EP4560368A3 (en) | 2017-11-03 | 2025-08-20 | Pacific Biosciences of California, Inc. | Systems, devices, and methods for improved optical waveguide transmission and alignment |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| US10655168B2 (en) | 2017-12-22 | 2020-05-19 | Pacific Biosciences Of California, Inc. | Modified biotin-binding proteins for immobilization |
| WO2019152395A1 (en) | 2018-01-31 | 2019-08-08 | Bio-Rad Laboratories, Inc. | Methods and compositions for deconvoluting partition barcodes |
| CN108375672B (zh) * | 2018-02-14 | 2022-06-24 | 京东方科技集团股份有限公司 | 一种生物检测芯片及其检测方法 |
| US11512002B2 (en) | 2018-04-18 | 2022-11-29 | University Of Virginia Patent Foundation | Silica materials and methods of making thereof |
| WO2020006421A1 (en) | 2018-06-29 | 2020-01-02 | Pacific Biosciences Of California, Inc. | Methods and compositions for delivery of molecules and complexes to reaction sites |
| EP4249651B1 (en) | 2018-08-20 | 2025-01-29 | Bio-Rad Laboratories, Inc. | Nucleotide sequence generation by barcode bead-colocalization in partitions |
| US11527808B2 (en) | 2019-04-29 | 2022-12-13 | Aptiv Technologies Limited | Waveguide launcher |
| WO2021152586A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Methods of analyzing microbiome, immunoglobulin profile and physiological state |
| US12535420B2 (en) | 2020-02-18 | 2026-01-27 | Pacific Biosciences Of California, Inc. | Highly multiplexed nucleic acid sequencing systems |
| WO2021214766A1 (en) | 2020-04-21 | 2021-10-28 | Yeda Research And Development Co. Ltd. | Methods of diagnosing viral infections and vaccines thereto |
| EP3951352B1 (en) * | 2020-08-06 | 2023-10-04 | Cellular Highways Ltd. | Apparatus for transmission optical measurements with a window in an opaque substrate |
| US11362436B2 (en) * | 2020-10-02 | 2022-06-14 | Aptiv Technologies Limited | Plastic air-waveguide antenna with conductive particles |
| US11757166B2 (en) | 2020-11-10 | 2023-09-12 | Aptiv Technologies Limited | Surface-mount waveguide for vertical transitions of a printed circuit board |
| US11681015B2 (en) | 2020-12-18 | 2023-06-20 | Aptiv Technologies Limited | Waveguide with squint alteration |
| US11901601B2 (en) | 2020-12-18 | 2024-02-13 | Aptiv Technologies Limited | Waveguide with a zigzag for suppressing grating lobes |
| US11626668B2 (en) | 2020-12-18 | 2023-04-11 | Aptiv Technologies Limited | Waveguide end array antenna to reduce grating lobes and cross-polarization |
| US11502420B2 (en) | 2020-12-18 | 2022-11-15 | Aptiv Technologies Limited | Twin line fed dipole array antenna |
| US11749883B2 (en) | 2020-12-18 | 2023-09-05 | Aptiv Technologies Limited | Waveguide with radiation slots and parasitic elements for asymmetrical coverage |
| US11444364B2 (en) | 2020-12-22 | 2022-09-13 | Aptiv Technologies Limited | Folded waveguide for antenna |
| US11668787B2 (en) | 2021-01-29 | 2023-06-06 | Aptiv Technologies Limited | Waveguide with lobe suppression |
| US12058804B2 (en) | 2021-02-09 | 2024-08-06 | Aptiv Technologies AG | Formed waveguide antennas of a radar assembly |
| US11721905B2 (en) | 2021-03-16 | 2023-08-08 | Aptiv Technologies Limited | Waveguide with a beam-forming feature with radiation slots |
| US11616306B2 (en) | 2021-03-22 | 2023-03-28 | Aptiv Technologies Limited | Apparatus, method and system comprising an air waveguide antenna having a single layer material with air channels therein which is interfaced with a circuit board |
| EP4084222A1 (en) | 2021-04-30 | 2022-11-02 | Aptiv Technologies Limited | Dielectric loaded waveguide for low loss signal distributions and small form factor antennas |
| US11973268B2 (en) | 2021-05-03 | 2024-04-30 | Aptiv Technologies AG | Multi-layered air waveguide antenna with layer-to-layer connections |
| KR20240006033A (ko) | 2021-05-04 | 2024-01-12 | 퍼시픽 바이오사이언스 오브 캘리포니아, 인크. | 축소된 규모의 단위 셀을 갖는 통합 분석 장치의 어레이 |
| US11962085B2 (en) | 2021-05-13 | 2024-04-16 | Aptiv Technologies AG | Two-part folded waveguide having a sinusoidal shape channel including horn shape radiating slots formed therein which are spaced apart by one-half wavelength |
| US11616282B2 (en) | 2021-08-03 | 2023-03-28 | Aptiv Technologies Limited | Transition between a single-ended port and differential ports having stubs that match with input impedances of the single-ended and differential ports |
| US12224502B2 (en) | 2021-10-14 | 2025-02-11 | Aptiv Technologies AG | Antenna-to-printed circuit board transition |
| US12456816B2 (en) | 2022-05-02 | 2025-10-28 | Aptiv Technologies AG | Waveguide with slot antennas and reflectors |
| US12265172B2 (en) | 2022-05-25 | 2025-04-01 | Aptiv Technologies AG | Vertical microstrip-to-waveguide transition |
| US12315999B2 (en) | 2022-07-15 | 2025-05-27 | Aptiv Technologies AG | Solderable waveguide antenna |
| US12424767B2 (en) | 2022-11-15 | 2025-09-23 | Aptiv Technologies AG | Planar surface features for waveguide and antenna |
| US12537308B2 (en) | 2023-01-24 | 2026-01-27 | Aptiv Technologies AG | Symmetrical two-piece waveguide |
| US12148992B2 (en) | 2023-01-25 | 2024-11-19 | Aptiv Technologies AG | Hybrid horn waveguide antenna |
| US12506272B2 (en) | 2023-05-16 | 2025-12-23 | Aptiv Technologies AG | Production-tolerant multi-part antenna system |
| US20260015601A1 (en) | 2024-07-15 | 2026-01-15 | Pacific Biosciences Of California, Inc. | Improved loading of molecules and complexes to reaction sites |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1251609A (zh) * | 1997-02-12 | 2000-04-26 | 尤金·Y·查恩 | 分析聚合物的方法和产品 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5624711A (en) * | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| US5976336A (en) * | 1997-04-25 | 1999-11-02 | Caliper Technologies Corp. | Microfluidic devices incorporating improved channel geometries |
| US6917726B2 (en) * | 2001-09-27 | 2005-07-12 | Cornell Research Foundation, Inc. | Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes |
| NO315342B1 (no) * | 2001-12-27 | 2003-08-18 | Optoplan As | Fiberoptisk sensor |
| CA2579150C (en) * | 2004-09-17 | 2014-11-25 | Pacific Biosciences Of California, Inc. | Apparatus and method for analysis of molecules |
| JP2006115742A (ja) * | 2004-10-20 | 2006-05-11 | Sumitomo Precision Prod Co Ltd | 核酸増幅方法、核酸増幅装置及び核酸検知システム |
| CN101915957B (zh) * | 2006-06-12 | 2012-12-12 | 加利福尼亚太平洋生物科学公司 | 实施分析反应的基材 |
| US9176062B2 (en) * | 2006-12-21 | 2015-11-03 | Koninklijke Philips N.V. | Aperture biosensor with trenches |
-
2007
- 2007-06-11 CN CN2010102565357A patent/CN101915957B/zh active Active
- 2007-06-11 EP EP07845184.6A patent/EP2027253A4/en not_active Withdrawn
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- 2007-06-11 US US11/761,251 patent/US7486865B2/en active Active
- 2007-06-11 EP EP14188883.4A patent/EP2857829B1/en active Active
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- 2007-06-11 WO PCT/US2007/070901 patent/WO2007149724A2/en not_active Ceased
- 2007-06-11 CA CA2654470A patent/CA2654470C/en active Active
-
2008
- 2008-12-22 US US12/341,556 patent/US7907800B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1251609A (zh) * | 1997-02-12 | 2000-04-26 | 尤金·Y·查恩 | 分析聚合物的方法和产品 |
Non-Patent Citations (1)
| Title |
|---|
| K.T. Samiee et al.Zero Mode Waveguides for Single-Molecule Spectroscopy on Lipid Membranes.《Biophysical Journal》.2006,第90卷(第9期),3288-3299. * |
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| EP2857829B1 (en) | 2017-08-09 |
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| CN101915957A (zh) | 2010-12-15 |
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| AU2007261114B2 (en) | 2012-07-12 |
| CN101467082B (zh) | 2011-12-14 |
| US20080095488A1 (en) | 2008-04-24 |
| CN101467082A (zh) | 2009-06-24 |
| CA2654470A1 (en) | 2007-12-27 |
| WO2007149724A2 (en) | 2007-12-27 |
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