CN101896817A - 用于结直肠癌的标记物组 - Google Patents

用于结直肠癌的标记物组 Download PDF

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Publication number
CN101896817A
CN101896817A CN2008801199284A CN200880119928A CN101896817A CN 101896817 A CN101896817 A CN 101896817A CN 2008801199284 A CN2008801199284 A CN 2008801199284A CN 200880119928 A CN200880119928 A CN 200880119928A CN 101896817 A CN101896817 A CN 101896817A
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CN
China
Prior art keywords
seprase
crc
ferritin
markers
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2008801199284A
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English (en)
Chinese (zh)
Inventor
J·卡尔
H·安德烈斯
U·加扎雷克
W·罗林格
N·威尔德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07023897A external-priority patent/EP2071337A1/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN101896817A publication Critical patent/CN101896817A/zh
Pending legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57535—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the large intestine, e.g. colon, rectum or anus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN2008801199284A 2007-12-10 2008-12-08 用于结直肠癌的标记物组 Pending CN101896817A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07023897.7 2007-12-10
EP07023897A EP2071337A1 (en) 2007-12-10 2007-12-10 Seprase as a marker for cancer
EP08017119 2008-09-29
EP08017119.2 2008-09-29
PCT/EP2008/010386 WO2009074276A2 (en) 2007-12-10 2008-12-08 Marker panel for colorectal cancer

Publications (1)

Publication Number Publication Date
CN101896817A true CN101896817A (zh) 2010-11-24

Family

ID=40344417

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801199284A Pending CN101896817A (zh) 2007-12-10 2008-12-08 用于结直肠癌的标记物组

Country Status (7)

Country Link
US (1) US20100240068A1 (https=)
EP (1) EP2223116B1 (https=)
JP (2) JP5591711B2 (https=)
CN (1) CN101896817A (https=)
CA (1) CA2701970A1 (https=)
ES (1) ES2527649T3 (https=)
WO (1) WO2009074276A2 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102183662A (zh) * 2011-03-22 2011-09-14 浙江大学 一种大肠癌预后预测模型的建立方法
CN107110865A (zh) * 2014-08-22 2017-08-29 雅培制药有限公司 用于结肠直肠癌的早期检测的方法

Families Citing this family (20)

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Publication number Priority date Publication date Assignee Title
CN108181457B (zh) 2009-03-12 2021-03-30 癌症预防和治疗有限公司 鉴定、评估、预防以及治疗肺疾病的方法及试剂盒
AU2010264067A1 (en) * 2009-06-23 2012-01-19 Eventus Diagnostics Israel Ltd. A method and system for the detection of cancer
EP2426615A1 (en) 2010-08-06 2012-03-07 Roche Diagnostics GmbH Evaluation device for assisting in the assessment of colorectal cancer
WO2012047899A2 (en) * 2010-10-04 2012-04-12 The Johns Hopkins University Novel dna hypermethylation diagnostic biomarkers for colorectal cancer
EP2463659A1 (en) * 2010-12-13 2012-06-13 Université de Liège Biomarkers for cancer diagnosis
JP2014509736A (ja) * 2011-03-11 2014-04-21 エフ．ホフマン−ラ ロシュ アーゲー 慢性閉塞性肺疾患（ｃｏｐｄ）のマーカーとしてのセプラーゼ
AU2012249288C1 (en) * 2011-04-29 2017-12-21 Lung Cancer Proteomics Llc Methods of identification and diagnosis of lung diseases using classification systems and kits thereof
SG11201504241QA (en) * 2012-11-30 2015-06-29 Applied Proteomics Inc Method for evaluation of presence of or risk of colon tumors
EP2916134B1 (en) 2014-03-05 2017-08-16 Roche Diagnostics GmbH Use of Seprase for differential diagnosis of acute dyspnea
WO2016164815A1 (en) 2015-04-10 2016-10-13 Applied Proteomics, Inc. Protein biomarker panels for detecting colorectal cancer and advanced adenoma
BR112018017336A2 (pt) 2016-03-07 2018-12-26 Hoffmann La Roche método in vitro para detectar um anticorpo para p53 (anticorpo anti-p53) em uma amostra e polipeptídeo de fusão
CN110709936A (zh) 2017-04-04 2020-01-17 肺癌蛋白质组学有限责任公司 用于早期肺癌预后的基于血浆的蛋白质概况分析
AU2019252672B2 (en) 2018-04-12 2025-08-14 Board Of Regents, The University Of Texas System Biomarker for detecting cancer
ES2952139T3 (es) * 2019-03-01 2023-10-27 Advanced Marker Discovery S L Firma proteica para el diagnóstico de cáncer colorrectal y/o etapa precancerosa del mismo
CN109902411B (zh) * 2019-03-07 2020-08-11 三峡大学 土壤重金属含量检测建模方法及装置、检测方法及装置
WO2021024009A1 (en) * 2019-08-02 2021-02-11 Shanghai Yunxiang Medical Technology Co., Ltd. Methods and compositions for providing colon cancer assessment using protein biomarkers
EP4041888A4 (en) 2019-10-11 2023-11-01 Guardant Health, Inc. USE OF CELLULAR BACTERIAL NUCLEIC ACIDS FOR CANCER DETECTION
WO2023282916A1 (en) 2021-07-09 2023-01-12 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
EP4179111B1 (en) 2020-07-10 2024-04-03 Guardant Health, Inc. Methods of detecting genomic rearrangements using cell free nucleic acids
CN112951332A (zh) * 2021-02-25 2021-06-11 北京博富瑞基因诊断技术有限公司 一种基于aGVHD biomarker的重度肠道aGVHD模型的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953639A1 (en) * 1998-04-30 1999-11-03 Boehringer Ingelheim International GmbH FAPalpha-specific antibody with improved producibility

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US5455160A (en) * 1993-05-27 1995-10-03 Fagerhol; Magne K. Diagnostic test and kit for disease or disorders in the digestive system
US5695761A (en) * 1993-12-23 1997-12-09 Rutgers University Suppression of nitric oxide production by osteopontin
US6414219B1 (en) * 1998-06-30 2002-07-02 Rutgers, The State University Of New Jersey Osteopontin knock-out mouse and methods of use thereof
AU8843701A (en) * 2000-09-09 2002-03-22 Univ New York State Res Found Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
DE602005014386D1 (de) * 2004-12-23 2009-06-18 Roche Diagnostics Gmbh Verwendung von cyfra 21-1 und osteopontin als marker für kolorektalkarzinome
US7399869B2 (en) * 2005-05-19 2008-07-15 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
CA2632327A1 (en) * 2005-12-22 2007-06-28 F. Hoffmann-La Roche Ag Use of a marker combination comprising osteopontin and carcinoembryonic antigen in the assessment of colorectal cancer
EP1994415B9 (en) * 2006-03-13 2015-12-16 Becton Dickinson and Company Diagnosis and prognosis of dipeptidyl peptidase-associated disease states

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0953639A1 (en) * 1998-04-30 1999-11-03 Boehringer Ingelheim International GmbH FAPalpha-specific antibody with improved producibility

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KALYANI NARRA1 ET AL: "Phase II Trial of Single Agent Val-boroPro (Talabostat) Inhibiting Fibroblast Activation Protein in Patients with Metastatic Colorectal Cancer", 《[CANCER BIOLOGY & THERAPY》 *
NAOHIRO ARIGA ET AL: "STROMAL EXPRESSION OF FIBROBLAST ACTIVATION PROTEIN/SEPRASE, ACELL MEMBRANE SERINE PROTEINASE AND GELATINASE, IS ASSOCIATEDWITH LONGER SURVIVAL IN PATIENTS WITH INVASIVE DUCTALCARCINOMA OF BREAST", 《INT. J. CANCER 》 *
SATOSHI IWASAB ET AL: "‘Increased expression of seprase, a membrane-type serine protease, is associated with lymph node metastasis in human colorectal cancer", 《CANCER LETTERS》 *
YAMAGUCHI ET AL.: "Expression of p53 Protein in ColorectalCancer and Its Relationship to Short-Term Prognosis", 《CANCER》 *
张雪峰 等: "Sep rase 表达与人结直肠癌临床病理特征的关系", 《中国普外基础与临床杂志》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102183662A (zh) * 2011-03-22 2011-09-14 浙江大学 一种大肠癌预后预测模型的建立方法
CN107110865A (zh) * 2014-08-22 2017-08-29 雅培制药有限公司 用于结肠直肠癌的早期检测的方法
CN107110865B (zh) * 2014-08-22 2020-01-10 雅培制药有限公司 用于结肠直肠癌的早期检测的方法

Also Published As

Publication number Publication date
JP2014211452A (ja) 2014-11-13
EP2223116A2 (en) 2010-09-01
US20100240068A1 (en) 2010-09-23
CA2701970A1 (en) 2009-06-18
EP2223116B1 (en) 2014-11-19
WO2009074276A3 (en) 2009-08-20
JP2011506917A (ja) 2011-03-03
ES2527649T3 (es) 2015-01-28
JP5591711B2 (ja) 2014-09-17
WO2009074276A2 (en) 2009-06-18

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