CN101865840A - Surface plasmon resonance imaging sensing system - Google Patents
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Abstract
The invention relates to a surface plasmon resonance imaging sensing system, which comprises a plasma resonator with isosceles triangle cross-section, wherein the plane of the bottom side of the isosceles triangle is of a sensing plane, and a layer of metal reflection film is plated on the sensing plane; a sample pool with an inlet and an outlet is arranged on the metal reflection film, and one of the planes of the two sides of equal length is used as an incident plane, and the other thereof is used as an emittance plane; a power source, a beam shaper and a polarizer are sequentially arranged on an incident light path which is vertical to the incident plane to reach the sensing plane, and an analyzer, an imaging lens group and an area array photoelectric sensor are sequentially arranged on a reflection light path generated by the sensing plane; and the area array photoelectric sensor is positioned on a focal plane of the imaging lens group and is connected with an external computer. The surface plasmon resonance imaging sensing system is characterized in that: the light source is a non-coherent light source, and a narrow-band filter is arranged between the polarizer and the incident surface. The invention can be widely used in food safety detection, pesticide residue detection, bio-molecule detection, bio-terrorist detection and other fields.
Description
Technical field
The present invention relates to a kind of biochemical substances detection system, particularly about a kind of high-throughout surface plasmon resonance imaging sensing system.
Background technology
(Surface P1asmon Resonance SPR) is just found by Wood in eighties of last century surface plasma body resonant vibration.The sixties, the method for usefulness excited by visible light surface plasma that Germany scientist Otto and Kretchmann have distinguished independent invention.The eighties, Sweden scientist Liedberg is used for this technology the detection of interaction of biomacromolecules.But the SPR technology be utilize incident light under certain condition exciting media and metal interface surface plasma wave (Surface Plasmon Wave SPW), and then causes the principle that energy of reflection light descends significantly.Because the SPR technology has high sensitivity, high precision, be easy to realize specific detection and advantage such as real-time, now has been widely applied to industries such as biology, medicine, food quality safety, chemistry and environmental monitoring.The SPR technology mainly adopts wavelength detection, angle detection, strength investigation and four kinds of measuring methods of phase detection at present.Wherein, wavelength detection is to adopt a fixing incident angle, by scanning different lambda1-wavelengths, measures resonant wavelength and changes, and obtains the physics or the chemical property situation of change of determinand.Angle detection is by measuring the variation of resonance angle, obtaining the physics or the chemical property situation of change of determinand.Strength investigation is to make the Strength Changes violent position of system works at the skew resonance point, changes by surveying light intensity, obtains the physics or the chemical property situation of change of determinand.Phase detection is that incident angle is fixed near the resonance angle, surveys reflective phase and changes, and obtains the physics or the chemical property situation of change of determinand.SPR technology based on above-mentioned four kinds of methods has produced many patents, such as: U.S. Pat 6208422, China applies for a patent (application number 01136668.0,200510108184.4).But above-mentioned patent all adopts the coherent light of laser or laser diode as the SPR light source, and coherent light or partially coherent light are easy to generate laser speckle, interference measurement results.Particularly in the SPR imaging technique, the influence that coherent light or partially coherent light laser speckle produce is even more serious, can cause the measurement mistake when serious.
Summary of the invention
At the problems referred to above, the purpose of this invention is to provide a kind of employing incoherent light as light source, can eliminate laser speckle the surface plasmon resonance imaging sensing system of influence.
For achieving the above object, the present invention takes following technical scheme: a kind of surface plasmon resonance imaging sensing system, it comprises that an xsect is the plasma resonance device of isosceles triangle, the plane, place, base of described isosceles triangle is the sensing plane, plating is provided with the layer of metal reflectance coating on the described sensing plane, and described metallic reflective coating is provided with a sample cell with import and outlet; One on the plane, two waist places of described isosceles triangle is as a plane of incidence, and another is disposed with light source, beam shaping and the polarizer as exit facet on input path on the described sensing of vertical arrival with described plane of incidence plane; By being provided with analyzer, imaging lens group and face array photoelectric sensor according to drink on the reflected light path of described sensing plane generation; Described face array photoelectric sensor is positioned on the focal plane of described imaging lens group, and described face array photoelectric sensor connects an extraneous computing machine; It is characterized in that: described light source is an incoherent light source, is provided with a narrowband light filter between the described polarizer and the plane of incidence.
Described incoherent light source is any in white light source, broadband LASER Light Source and the led light source.
Described incoherent light source is the tungsten halogen lamp light source in the described white light source.
Described narrowband light filter is a kind of in monochromator, liquid crystal filter and the interference narrow band pass filter.
Described narrowband light filter is that passband width value scope is the interference narrow band pass filter of 0.1～2nm.
Described narrowband light filter is that passband width is the interference narrow band pass filter of 1nm, and its centre wavelength is 633nm.
Described metallic reflective coating is interior golden film or the silverskin of scope of 35nm～55nm.
Described beam shaping is for expanding a kind of in bundle shaping mirror group and the collimating mirror, described imaging lens group is a kind of in the imaging lens group of fixed focal length and the pancratic imaging lens group, and described face array photoelectric sensor is a kind of in area array CCD device, face battle array CMOS camera and the face battle array photodiode array.
The present invention is owing to take above technical scheme, it has the following advantages: 1, the present invention is owing to be provided with incoherent light source and narrowband light filter in input path, therefore the light that incoherent light source can be produced through beam shaping expand bundle and the polarizer rise inclined to one side after, incoherent light narrower in narrowband light filter is selected red range is as incident light, thereby avoided the speckle phenomena of traditional coherent light source, detection flux and imaging signal to noise ratio (S/N ratio) all are significantly increased.2, because incoherent light source of the present invention can adopt any in white light source, broadband LASER Light Source and the led light source, therefore can reduce cost, be easy to commercialization.3, because narrowband light filter of the present invention is a kind of in monochromator, liquid crystal filter and the interference narrow band pass filter, therefore further reduced cost, and stable performance.The present invention can be widely used in the fields such as food safety detection, Detecting Pesticide, biomolecule detection and bio-terrorism Molecular Detection.
Description of drawings
Fig. 1 is a structural representation of the present invention
Fig. 2 is a light path synoptic diagram of the present invention
Embodiment
Below in conjunction with drawings and Examples the present invention is described in detail.
As shown in Figure 1, the present invention includes a surface plasma body resonant vibration device 1, an incoherent light source 2, a beam shaping 3, a polarizer 4, a narrowband light filter 5, an analyzer 6, an imaging lens group 7 and a face array photoelectric sensor 8.Wherein, surface plasma body resonant vibration device 1 is a prism, and its xsect is an isoceles triangle shape, is bottom surface A with the face at the place, base of this isoceles triangle shape, is isosceles side B, C with two waist place faces of this isoceles triangle shape.The bottom surface A of surface plasma body resonant vibration device 1 goes up plating and is provided with the layer of metal reflectance coating, as sensing of the present invention plane 11.Metallic reflective coating can be golden film, also can select silverskin, and its thickness can be selected in the scope of 35nm～55nm.In the present embodiment, what metallic reflective coating was selected is that thickness is the golden film of 47.5nm.Metallic reflective coating is provided with a sample cell 12, has an import 13 that can supply testing sample to flow on the sample cell 12, and an outlet 14 for the testing sample outflow, and testing sample is evenly distributed on the sensing plane 11 after flowing into sample cell 12.
As shown in Figure 2, when the present invention works, after the incoherent light that incoherent light source 2 is sent is handled through the expansion bundle of beam shaping 3, enter and produce an incoherent linearly polarized light in the polarizer 4, this incoherent linearly polarized light is after narrowband light filter 5 Filtering Processing, the incoherent linearly polarized light that obtains in the red spectral band scope impinges perpendicularly on the isosceles side B of surface plasma body resonant vibration device 1, enter surface plasma body resonant vibration device 1 and incide on the metallic reflective coating and testing sample on the sensing plane 11, when if incident angle satisfies the resonance angle size, metallic reflective coating and testing sample produce surface plasma wave under the exciting of the incoherent linearly polarized light of incident, thereby cause that energy of reflection light descends significantly; If during the size of incident angle deviation resonance angle, incident light is by the metallic reflective coating total reflection.The noncoherent linearly polarized light that is reflected out passes through analyzer 6 and imaging lens group 7 successively, is imaged at last on the face array photoelectric sensor 8.Thereby the catoptrical light intensity of face array photoelectric sensor 8 records changes, by computing machine the picture signal of face array photoelectric sensor 8 records is gathered and signal extraction, therefore can obtain the variations in refractive index of testing sample or the information of concentration in real time according to the light intensity image information of face array photoelectric sensor 8 records.In the said process, when the incident angle size on being incident on sensing plane 11 satisfies the resonance angle size, the catoptrical light intensity that face array photoelectric sensor 8 detects is the most weak, when the incident angle size deviation resonance angle on being incident on sensing plane 11 was big or small, the catoptrical light intensity that face array photoelectric sensor 8 detects was very strong.
The various embodiments described above only are used to illustrate the present invention, and wherein the structure of each parts, connected mode etc. all can change to some extent, and every equivalents of carrying out on the basis of technical solution of the present invention and improvement all should not got rid of outside protection scope of the present invention.
Claims (10)
1. surface plasmon resonance imaging sensing system, it comprises that an xsect is the surface plasma body resonant vibration device of isosceles triangle, the plane, place, base of described isosceles triangle is the sensing plane, plating is provided with the layer of metal reflectance coating on the described sensing plane, and described metallic reflective coating is provided with a sample cell with import and outlet; One on the plane, two waist places of described isosceles triangle is as a plane of incidence, and another is disposed with light source, beam shaping and the polarizer as exit facet on input path on the described sensing of vertical arrival with described plane of incidence plane; Be disposed with analyzer, imaging lens group and face array photoelectric sensor on the reflected light path by the generation of described sensing plane; Described face array photoelectric sensor is positioned on the focal plane of described imaging lens group, and described face array photoelectric sensor connects an extraneous computing machine; It is characterized in that: described light source is an incoherent light source, is provided with a narrowband light filter between the described polarizer and the plane of incidence.
2. a kind of surface plasmon resonance imaging sensing system as claimed in claim 1 is characterized in that: described incoherent light source is any in white light source, broadband LASER Light Source and the led light source.
3. a kind of surface plasmon resonance imaging sensing system as claimed in claim 2 is characterized in that: described incoherent light source is the tungsten halogen lamp light source in the described white light source.
4. as claim 1 or 2 or 3 described a kind of surface plasmon resonance imaging sensing systems, it is characterized in that: described narrowband light filter is a kind of in monochromator, liquid crystal filter and the interference narrow band pass filter.
5. a kind of surface plasmon resonance imaging sensing system as claimed in claim 4 is characterized in that: described narrowband light filter is that passband width value scope is the interference narrow band pass filter of 0.1～2nm.
6. a kind of surface plasmon resonance imaging sensing system as claimed in claim 5 is characterized in that: described narrowband light filter is that passband width is the interference narrow band pass filter of 1nm, and its centre wavelength is 633nm.
7. as claim 1 or 2 or 3 or 5 or 6 described a kind of surface plasmon resonance imaging sensing systems, it is characterized in that: described metallic reflective coating is interior golden film or the silverskin of scope of 35nm～55nm.
8. a kind of surface plasmon resonance imaging sensing system as claimed in claim 4 is characterized in that: described metallic reflective coating is interior golden film or the silverskin of scope of 45nm～53nm.
9. as claim 1 or 2 or 3 or 5 or 6 or 8 described a kind of surface plasmon resonance imaging sensing systems, it is characterized in that: described beam shaping is for expanding a kind of in bundle shaping mirror group and the collimating mirror, described imaging lens group is a kind of in the imaging lens group of fixed focal length and the pancratic imaging lens group, and described face array photoelectric sensor is a kind of in area array CCD device, face battle array CMOS camera and the face battle array photodiode array.
10. as claim 4 or 7 described a kind of surface plasmon resonance imaging sensing systems, it is characterized in that: described beam shaping is for expanding a kind of in bundle shaping mirror group and the collimating mirror, described imaging lens group is a kind of in the imaging lens group of fixed focal length and the pancratic imaging lens group, and described face array photoelectric sensor is a kind of in area array CCD device, face battle array CMOS camera and the face battle array photodiode array.
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| CN102253005A (en) * | 2011-04-15 | 2011-11-23 | 深圳大学 | Surface plasmon resonance sensing detection system and method |
| CN102253014A (en) * | 2011-04-15 | 2011-11-23 | 深圳大学 | System and method for surface plasmon resonance sensing detection |
| CN102608041A (en) * | 2012-04-05 | 2012-07-25 | 清华大学深圳研究生院 | Method and device for detecting charging state of vanadium cell |
| CN102944537A (en) * | 2012-10-23 | 2013-02-27 | 深圳大学 | Detection system and detection method based on SPR |
| CN103454254A (en) * | 2013-09-09 | 2013-12-18 | 中国科学院苏州生物医学工程技术研究所 | Detection unit of surface plasmon resonance (SPR) instrument |
| CN103454253A (en) * | 2013-06-25 | 2013-12-18 | 复旦大学 | Organic phosphorus detection method based on surface plasmon resonance |
| CN103512865A (en) * | 2013-09-13 | 2014-01-15 | 南京航空航天大学 | Device and method for generating surface plasma wave |
| CN103728272A (en) * | 2013-12-11 | 2014-04-16 | 王丽红 | SPR (Surface Plasma Resonance) imaging detection device |
| CN103728271A (en) * | 2013-12-11 | 2014-04-16 | 王丽红 | SPR (Surface Plasma Resonance) imaging detection device and light source thereof |
| CN103792212A (en) * | 2014-02-18 | 2014-05-14 | 深圳大学 | Optical fiber surface plasma resonance sensor, detection system and method |
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| CN106404751A (en) * | 2016-08-30 | 2017-02-15 | 上海理工大学 | Cylindrical vector beam excitation and surface plasma resonance sensing device |
| CN107764776A (en) * | 2017-04-18 | 2018-03-06 | 南京大学 | Multi-wavelength adjustable meter surface plasma resonance imaging device and its application |
| CN108289179A (en) * | 2018-02-08 | 2018-07-17 | 深圳泰华安全技术工程有限公司 | A method of improving video signal collection anti-interference ability |
| CN109490278A (en) * | 2018-09-10 | 2019-03-19 | 桂林电子科技大学 | The rotary SPR of triangle microprism tests optical chip |
| CN109799209A (en) * | 2019-01-31 | 2019-05-24 | 马佑桥 | A kind of simplification glass prism SPR excitation apparatus based on parabolic reflector |
| CN110927121A (en) * | 2019-12-05 | 2020-03-27 | 深圳大学 | Phase type SPR detection device and method based on white light interference spectrum |
| CN112098371A (en) * | 2020-09-15 | 2020-12-18 | 深圳大学 | Strength type SPRi sensing system and method based on dual-wavelength difference |
| CN113466184A (en) * | 2021-07-05 | 2021-10-01 | 深圳市检验检疫科学研究院 | Stacked SPR (surface plasmon resonance) biosensor chip based on ITO (indium tin oxide) |
| CN114152569A (en) * | 2021-11-17 | 2022-03-08 | 北京英柏生物科技有限公司 | Imaging optical system based on SPR angular spectrum |
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| CN102253014A (en) * | 2011-04-15 | 2011-11-23 | 深圳大学 | System and method for surface plasmon resonance sensing detection |
| CN102608041A (en) * | 2012-04-05 | 2012-07-25 | 清华大学深圳研究生院 | Method and device for detecting charging state of vanadium cell |
| CN102608041B (en) * | 2012-04-05 | 2014-03-05 | 清华大学深圳研究生院 | Method and device for detecting charging state of vanadium cell |
| CN102944537A (en) * | 2012-10-23 | 2013-02-27 | 深圳大学 | Detection system and detection method based on SPR |
| CN102944537B (en) * | 2012-10-23 | 2016-04-06 | 深圳大学 | A kind of detection system based on SPR and detection method thereof |
| CN103454253A (en) * | 2013-06-25 | 2013-12-18 | 复旦大学 | Organic phosphorus detection method based on surface plasmon resonance |
| CN103454253B (en) * | 2013-06-25 | 2016-04-06 | 复旦大学 | Based on the organic phosphorus detection method of surface plasma body resonant vibration |
| CN103454254A (en) * | 2013-09-09 | 2013-12-18 | 中国科学院苏州生物医学工程技术研究所 | Detection unit of surface plasmon resonance (SPR) instrument |
| CN103512865A (en) * | 2013-09-13 | 2014-01-15 | 南京航空航天大学 | Device and method for generating surface plasma wave |
| CN103512865B (en) * | 2013-09-13 | 2016-06-15 | 南京航空航天大学 | A kind of device and method producing surface plasma wave |
| CN103728271A (en) * | 2013-12-11 | 2014-04-16 | 王丽红 | SPR (Surface Plasma Resonance) imaging detection device and light source thereof |
| CN103728272B (en) * | 2013-12-11 | 2016-03-16 | 王丽红 | Surface plasma resonance image-forming pick-up unit |
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| CN103792212B (en) * | 2014-02-18 | 2017-01-04 | 深圳大学 | A kind of Fiber Optic Sensor Based on Surface Plasmon Resonance, detecting system and method |
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| CN106404751B (en) * | 2016-08-30 | 2019-01-22 | 上海理工大学 | A kind of column vector beam excitating surface plasma resonance sensing equipment |
| CN107764776A (en) * | 2017-04-18 | 2018-03-06 | 南京大学 | Multi-wavelength adjustable meter surface plasma resonance imaging device and its application |
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| CN109490278A (en) * | 2018-09-10 | 2019-03-19 | 桂林电子科技大学 | The rotary SPR of triangle microprism tests optical chip |
| CN109799209A (en) * | 2019-01-31 | 2019-05-24 | 马佑桥 | A kind of simplification glass prism SPR excitation apparatus based on parabolic reflector |
| CN109799209B (en) * | 2019-01-31 | 2022-04-29 | 马佑桥 | Simplified prism SPR excitation device based on parabolic reflector |
| CN110927121A (en) * | 2019-12-05 | 2020-03-27 | 深圳大学 | Phase type SPR detection device and method based on white light interference spectrum |
| CN110927121B (en) * | 2019-12-05 | 2022-07-05 | 深圳大学 | Phase type SPR detection device and method based on white light interference spectrum |
| CN112098371A (en) * | 2020-09-15 | 2020-12-18 | 深圳大学 | Strength type SPRi sensing system and method based on dual-wavelength difference |
| CN113466184A (en) * | 2021-07-05 | 2021-10-01 | 深圳市检验检疫科学研究院 | Stacked SPR (surface plasmon resonance) biosensor chip based on ITO (indium tin oxide) |
| CN113466184B (en) * | 2021-07-05 | 2023-12-15 | 深圳市检验检疫科学研究院 | ITO-based laminated SPR biosensing chip |
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