CN106404751B - A kind of column vector beam excitating surface plasma resonance sensing equipment - Google Patents
A kind of column vector beam excitating surface plasma resonance sensing equipment Download PDFInfo
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- CN106404751B CN106404751B CN201610777531.0A CN201610777531A CN106404751B CN 106404751 B CN106404751 B CN 106404751B CN 201610777531 A CN201610777531 A CN 201610777531A CN 106404751 B CN106404751 B CN 106404751B
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/71—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited
- G01N21/73—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light thermally excited using plasma burners or torches
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Abstract
The present invention provides a kind of column vector beam excitating surface plasma resonance sensing equipments, have the feature that, comprising: column vector beam excites unit, includes light source, beam shaping, polarization conversion component and the spatial light modulator being sequentially connected by an optical path；Surface plasma resonance sensing unit includes cylindrical prism and double-layer structure；Light processing unit, polarizing filter, dispersive optical elements and face array photoelectric sensor comprising optical path connection；And data analysis unit, wherein double-layer structure includes the metal layer of micro-nano structure layer with the outer surface that micro-nano structure layer is arranged in.Column vector beam excitating surface plasma resonance sensing equipment of the invention has many advantages, such as that structure is simple, stability is high, high sensitivity, consistency are high, is easy to expand without mechanical moving element, achievable region measurement and function.
Description
Technical field
The invention belongs to optical technical fields, and in particular to a kind of column vector beam excitating surface plasma resonance sensing
Device.
Background technique
Surface plasma resonance technology, English write a Chinese character in simplified form SPR, are a kind of new technologies to grow up from the 1990s,
Germany scientist Otto and Kretchmann have independently invented the method with excited by visible light surface plasma, section of Sweden
This technology is used for the detection of interaction of biomacromolecules by scholar Liedberg, and surface plasma resonance sensing technology is fast
Speed development, develops into particularly useful detection technique, is widely used in that environment measuring, food safety, life medicine, medicine examines
The every field such as disconnected, biomedicine, security protection, criminal investigation, quality inspection.Numerous areas is higher and higher to detection performance requirement, has the Supreme People's Procuratorate
The surface plasma resonance sensing equipment for surveying performance becomes one of trace materials measurement and analytical technology Hot spots for development.
Chinese invention patent (application No. is CN200510108184.4) discloses a kind of angle scanning surface plasma
Resonance measurement system, the measuring system include the light source for providing light beam, have deflected to provide in deflection angle ranges intrinsic deflection light beam
The beam deflector of light beam and the imaging telescope for light beam will have been deflected being mapped to incident beam.In addition, on existing market,
There is also the surface plasma body resonant vibration analyzers being commercialized, including BioCore series of products and SPR-Navi series to produce
Product.Although above-mentioned swept-angle SPR measurement system and surface plasma body resonant vibration analyzer have certain
Advantage, still, technically there is also many deficiencies for above-mentioned measuring system and surface plasma body resonant vibration analyzer, specifically such as
Under: (1) measuring principle using angle scanning principle measured, the portion there are mechanical moving element and for regulating and controlling angle scanning
Part influences measuring system reliability, and cannot achieve measurement consistency well.(2) measurement is based on light beam and metal layer phase
The surface plasmon resonance effect of interaction does not consider light beam vectorial property, and limitation tests and analyzes sensitivity in principle.
(3) light field is similar with the mechanism of action behavior in material effect region in measurement, cannot achieve region planar survey.(4) detection zone
It inside cannot achieve informative differentiation processing, influence detection sensitivity and consistency.(5) measuring system structure and measurement analysis with
Control is complicated, reduces system stability, influences systematic survey performance and application extension.
Summary of the invention
The present invention is to carry out to solve the above-mentioned problems, and it is an object of the present invention to provide a kind of no mechanical moving element, system
Structure is simple, high sensitivity, consistency are high, region measurement can be achieved, the column arrow that system stability is high and function is easy to expand
Measure beam excitation surface plasma resonance sensing equipment.
The technical solution adopted by the invention is as follows:
The present invention provides a kind of column vector beam excitating surface plasma resonance sensing equipments, for detecting detected sample
The material information of product characterized by comprising column vector beam excites unit, comprising being sequentially connected by an optical path for emitting light
The light source of beam, for light beam carry out shaping beam shaping, for the light beam after shaping to be converted to column vector beam
The spatial light modulator of polarization conversion component and the column vector beam for column vector beam to be modulated into excited state；Surface
Plasma resonance sensing unit is the column of right angled triangle comprising cross section for receiving the column vector beam of excited state
Shape prism and the double-layer structure being arranged on hypotenuse bottom surface, the column vector beam of excited state is from right angle trigonometry
First right-angle side plane vertical incidence of shape, after the plane total reflection of the bevel edge of right angled triangle, from the of right angled triangle
Two right-angle side plane vertical exits, obtain the light beam of the information light field with sample；Light processing unit, it is tested for receiving
The light beam of the information light field of sample is simultaneously handled, polarizing filter, dispersive optical elements comprising optical path connection and face battle array
Photoelectric sensor；And data analysis unit, it is connect with face array photoelectric sensor, for the information to treated sample
The light beam of light field is analyzed, and the material information of sample is obtained, wherein double-layer structure includes to be arranged in hypotenuse
Plane on micro-nano structure layer and be arranged in micro-nano structure layer outer surface metal layer.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where material information be refractive index, concentration and intermolecular force.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where light source be broadband incoherent light source or broadband laser light source.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where beam shaping be collimator and extender microscope group, collimating mirror and micro-nano beam shaping in any one.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where spatial light modulator be amplitude type spatial light modulator, phase type spatial light modulator, polarizability spatial light
Any one in modulator and compound spatial light modulator.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where micro-nano structure layer be spherical surface micro-nano structure array, free form surface micro-nano structure array, multi-panel cone micro-nano knot
Any one in structure array and micro-nano column array.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where dispersive optical elements are through grating, reflecting grating, echelle grating and distributed spectral filtering array
In any one.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where face array photoelectric sensor be surface array charge-coupled device, face battle array COMS device and optics microchannel sensor in
Any one.
In column vector beam excitating surface plasma resonance sensing equipment provided by the invention, can also have in this way
Feature: where metal layer is gold thin film.
The action and effect of invention
Related column vector beam excitating surface plasma resonance sensing equipment according to the present invention, because of column vector light
Light beam can be converted to the column vector beam of excited state by Shu Jifa unit, be placed with the surface plasma body resonant vibration of sample
Sensing unit obtains the light beam of the information light field with sample, light after being totally reflected to the column vector beam of excited state
Processing unit handles the light beam of the information light field of sample, and final data analytical unit is to treated sample
The light beam of information light field analyzed, obtain the material information of sample.So column vector beam of the invention excites table
Surface plasma resonance sensing device has that structure is simple, stability is high, high sensitivity, consistency are high, without mechanical moving element
And function is easy to the advantages that expanding.
Detailed description of the invention
Fig. 1 is that the structure of one center pillar vector beam excitation surface plasma resonance sensing equipment of the embodiment of the present invention is shown
It is intended to.
Specific embodiment
It is real below in order to be easy to understand the technical means, the creative features, the aims and the efficiencies achieved by the present invention
Example combination attached drawing is applied to be specifically addressed column vector beam excitating surface plasma resonance sensing equipment of the invention.
Fig. 1 is that the structure of one center pillar vector beam excitation surface plasma resonance sensing equipment of the embodiment of the present invention is shown
It is intended to.
As shown in Figure 1, in the present embodiment, column vector beam excitating surface plasma resonance sensing equipment 100 is used to
The parameters such as refractive index, concentration and the intermolecular force of high molecular weight protein substance are detected, it includes that column vector beam excitation is single
Member 10, surface plasma resonance sensing unit 20, light processing unit 30 and data analysis unit 40.
Column vector beam excitation unit 10 is used to be converted to light beam the column vector beam of excited state, it includes successively light
Light source 11, beam shaping 12, polarization conversion component 13 and the spatial light modulator 14 of road connection.
Light source 11 is used to emit light beam, and in the present embodiment, light source 11 is broadband incoherent light source, using broadband tungsten
Lamp source 11.In addition, light source 11 can also be broadband laser light source.
The light beam that beam shaping 12 is used to emit broadband tungsten light source 11 carries out shaping, in the present embodiment
In, beam shaping 12 is that collimation includes beam microscope group 12.In addition, beam shaping 12 can also be whole using collimating mirror or micro-nano light beam
Shape device.
Polarization conversion component 13 is used to the light beam after shaping being converted to column vector beam, in the present embodiment, optical rotation
Changing component 13 is reflective vector beam conversion element 13.In addition, polarization conversion component 13 can also be turned using refraction type light beam
Change element or micro-nano structure vector beam conversion element.
Spatial light modulator 14 is used to for column vector beam being modulated into the column vector beam of excited state, in the present embodiment
In, spatial light modulator 14 is phase type spatial light modulator 14.In addition, amplitude type space also can be used in spatial light modulator 14
Optical modulator or compound spatial light modulator.
Surface plasma resonance sensing unit 20 is used to receive the column vector beam of excited state, it includes cylindrical prism
21 and double-layer structure 22.
The cross section of cylindrical prism 21 is right angled triangle, one from right angled triangle of the column vector beam of excited state
Plane vertical incidence where right-angle side, after the bottom of the plane where the bevel edge in the right angled triangle is totally reflected, from
Planar exit where an other right-angle side for the right angled triangle.The setting of double-layer structure 22 is right angled triangle in cross section
Cylindrical prism 21 bevel edge where plane on, it includes 221 He of micro-nano structure layer in the plane being covered on where bevel edge
The metal layer 222 being covered on micro-nano structure layer 221, micro-nano structure layer 221 and metal layer 222 constitute sensitive zones, are detected
High molecular weight protein substance be placed on metal layer 222, the column vector beam of excited state has with high molecular weight protein position
When resonant wavelength, plasma resonance occurs on sensitive zones, forms resonance absorbing peak, the amplitude and resonance of resonance absorbing peak
Wavelength is related with the substance characteristics near sensitive zones.In the present embodiment, micro-nano structure layer 221 is spherical surface micro-nano structure battle array
Column, metal layer 222 are the gold thin film 222 with a thickness of 50nm.In addition, micro-nano structure layer 221 can also be free form surface micro-nano knot
Any one in structure array, multi-panel cone micro-nano structure array and micro-nano column array.
Light processing unit 30 is used to receive the light beam of the information light field of high molecular weight protein substance, it includes the inclined of optical path connection
Polarised filter 31, dispersive optical elements 32 and face array photoelectric sensor 33.
Polarizing filter 31 is used to receive the information of the planar exit where the other right-angle side from right angled triangle
The light beam of light field simultaneously filters, and in the present embodiment, polarizing filter 31 is high molecular material polarizing filter 31.In addition,
Polarizing filter 31 can also use liquid-crystal polarizing filters, binomial color material polarizing filter, prism polarizing filter with
And any one in bar structure polarizing filter.
Dispersive optical elements 32 are used to handle the light beam with information light field after optical filtering, concurrently add lustre to scattered,
In the present embodiment, dispersive optical elements 32 are through grating 32.In addition, dispersive optical elements 32 can also for reflecting grating, in
Any one in echelon and distributed spectral filtering array.
Face array photoelectric sensor 33 connect with through grating 32, and for receiving, through grating 32, treated that light field obtains for it
Field information, in the present embodiment, face array photoelectric sensor 33 are face battle array COMS device 33.In addition, face array photoelectric sensor 33 is also
It can be surface array charge-coupled device or optics microchannel sensor.
Data analysis unit 40 is connect with face battle array COMS device 33 by data line, it is used to what opposite battle array COMS device 33 obtained
Field information is analyzed, and the material informations such as the refractive index, concentration and intermolecular force of high molecular weight protein substance are obtained.?
In the present embodiment, data analysis unit 40 is computer 40.
The course of work of column vector beam excitating surface plasma resonance sensing equipment 100 involved in the present embodiment is such as
Under:
Firstly, detected high molecular weight protein substance is placed in gold thin film；Then, broadband tungsten light source 11 emits
Light beam out, collimation include beam microscope group 12 and carry out shaping to light beam, and reflective vector beam converting member 13 turns the light beam after shaping
Change column vector beam into, column vector beam is modulated into the column vector beam of excited state by phase type spatial light modulator 14；Into
One step, the plane vertical incidence where a right-angle side of the column vector beam of excited state in cylindrical prism 21, by oblique
Side total reflection, the column vector beam of excited state and high molecular weight protein substance are with micro-nano structure layer 221 and gold thin film 222
Sensitive zones interact, and obtain the light beam with information light field, have the light beam of information light field from cylindrical prism 21
Plane vertical exit where another right-angle side, the light beam with information light field are filtered by high molecular material polarizing filter 31
Light carries out dispersion using through grating 32, and face battle array COMS device 33 carries out the light field after reception dispersion and obtains field information, most
Afterwards, the substances letters such as the refractive index, concentration and intermolecular force of high molecular weight protein substance are obtained after the analysis of computer 40
Breath.
The action and effect of embodiment
The column vector beam excitating surface plasma resonance sensing equipment according to involved in the present embodiment, because of column vector
Light beam can be converted to the column vector beam of excited state by beam excitation unit, be placed with surface of high molecular weight protein substance etc. from
Daughter resonance sensing unit obtains the letter with high molecular weight protein substance after being totally reflected to the column vector beam of excited state
The light beam of light field is ceased, light processing unit handles the light beam of the information light field of high molecular weight protein substance, last computer pair
The light beam of the information light field of treated high molecular weight protein substance is analyzed, and the material information of high molecular weight protein substance is obtained.
So the column vector beam excitating surface plasma resonance sensing equipment of the present embodiment has, structure is simple, stability is high, clever
Sensitivity is high, consistency is high, is easy to the advantages that expanding without mechanical moving element and function.
In addition, column vector beam can be modulated into the column vector of excited state by the present embodiment amplitude type spatial light modulator
The column vector beam of light beam, excited state interacts in sensitive zones and measured matter, since different zones polarization state has
Otherness, and combine spherical surface micro-nano structure array it is microcosmic on vectorial field polarization characteristic, realize vector in different zones
Light field region Polarized Excitation surface plasma body resonant vibration realizes detection in different measurement points, and not by high molecular weight protein substance
With the limitation of regional location, it is achieved that region planar survey.
Above embodiment is preferred case of the invention, the protection scope being not intended to limit the invention.
Claims (9)
1. a kind of column vector beam excitating surface plasma resonance sensing equipment, for detecting the material information of sample,
It is characterised by comprising:
Column vector beam excites unit, comprising be sequentially connected by an optical path light source for emitting light beam, for the light beam into
The beam shaping of row shaping, polarization conversion component and use for the light beam after shaping to be converted to column vector beam
In the spatial light modulator for the column vector beam that the column vector beam is modulated into excited state；
Surface plasma resonance sensing unit is straight comprising cross section for receiving the column vector beam of the excited state
The cylindrical prism of angle triangle and the double-layer structure being arranged on the hypotenuse bottom surface, the excited state
Column vector beam from the first right-angle side plane vertical incidence of the right angled triangle, the right angled triangle bevel edge it is flat
After the total reflection of face, from the second right-angle side plane vertical exit of the right angled triangle, the letter with the sample is obtained
Cease the light beam of light field；
Light processing unit includes optical path connection for receiving the light beam of the information light field of the sample and being handled
Polarizing filter, dispersive optical elements and face array photoelectric sensor；And
Data analysis unit is connect with the face array photoelectric sensor, the information light for the sample described to treated
The light beam of field is analyzed, and the material information of the sample is obtained,
Wherein, the double-layer structure includes the micro-nano structure layer being arranged in the plane of the hypotenuse and is arranged in institute
State the metal layer of the outer surface of micro-nano structure layer.
2. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the material information is refractive index, concentration and intermolecular force.
3. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the light source is broadband incoherent light source or broadband laser light source.
4. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the beam shaping is any one in collimator and extender microscope group, collimating mirror and micro-nano beam shaping.
5. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the spatial light modulator is amplitude type spatial light modulator, phase type spatial light modulator, polarizability spatial light
Any one in modulator and compound spatial light modulator.
6. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the micro-nano structure layer is spherical surface micro-nano structure array, free form surface micro-nano structure array, multi-panel cone micro-nano knot
Any one in structure array and micro-nano column array.
7. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the dispersive optical elements are through grating, reflecting grating, echelle grating and distributed spectral filtering array
In any one.
8. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the face array photoelectric sensor is in surface array charge-coupled device, face battle array COMS device and optics microchannel sensor
Any one.
9. column vector beam excitating surface plasma resonance sensing equipment according to claim 1, it is characterised in that:
Wherein, the metal layer is gold thin film.
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| CN201610777531.0A CN106404751B (en) | 2016-08-30 | 2016-08-30 | A kind of column vector beam excitating surface plasma resonance sensing equipment |
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| CN201610777531.0A CN106404751B (en) | 2016-08-30 | 2016-08-30 | A kind of column vector beam excitating surface plasma resonance sensing equipment |
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| CN106404751B true CN106404751B (en) | 2019-01-22 |
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| WO2008010182A2 (en) * | 2006-07-17 | 2008-01-24 | Max Wiki | Analytical system comprising an arrangement for temporally variable spatial light modulation and detection method implemented thereby |
| CN101223435A (en) * | 2005-07-14 | 2008-07-16 | 3M创新有限公司 | Surface-enhanced spectroscopic method, flexible structured substrate, and method of making the same |
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| CN101865840A (en) * | 2010-06-07 | 2010-10-20 | 深圳国际旅行卫生保健中心 | Surface plasmon resonance imaging sensing system |
| CN103472576A (en) * | 2013-09-12 | 2013-12-25 | 北京信息科技大学 | Method and device for strengthening total internal reflection fluorescence microscopic imaging by means of surface plasma |
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2016
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101223435A (en) * | 2005-07-14 | 2008-07-16 | 3M创新有限公司 | Surface-enhanced spectroscopic method, flexible structured substrate, and method of making the same |
| WO2008010182A2 (en) * | 2006-07-17 | 2008-01-24 | Max Wiki | Analytical system comprising an arrangement for temporally variable spatial light modulation and detection method implemented thereby |
| CN101324523A (en) * | 2008-07-25 | 2008-12-17 | 杭州电子科技大学 | Surface plasma resonance optical spectrum sensor |
| CN101865840A (en) * | 2010-06-07 | 2010-10-20 | 深圳国际旅行卫生保健中心 | Surface plasmon resonance imaging sensing system |
| CN103472576A (en) * | 2013-09-12 | 2013-12-25 | 北京信息科技大学 | Method and device for strengthening total internal reflection fluorescence microscopic imaging by means of surface plasma |
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