CN101294900B - High-fineness cavity surface plasma resonance sensing equipment - Google Patents
High-fineness cavity surface plasma resonance sensing equipment Download PDFInfo
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- CN101294900B CN101294900B CN 200810061917 CN200810061917A CN101294900B CN 101294900 B CN101294900 B CN 101294900B CN 200810061917 CN200810061917 CN 200810061917 CN 200810061917 A CN200810061917 A CN 200810061917A CN 101294900 B CN101294900 B CN 101294900B
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Abstract
The invention relates to a high-finesse cavity surface plasma resonance sensing device. The prior sensing device has low detection sensitivity. The sensing device comprises a laser source, a surface plasma sensor and a photo detector. The surface plasma sensor is an isosceles triple prism, the bottom of the triple prism is plated with a plane metallic reflecting film, the side faces thereof are respectively plated with an incident high reflecting film and an outgoing high reflecting film, the sloping side faces are an incident face and an outgoing face of a beam, the bottom surface is a sensing plane, and the incident face and the outgoing face of the beam are the high reflectivity surface of the beam, thus forming a high-finesse cavity. The light intensity of the detecting beam of the detector, which exits the prism, is the beam produced by the effects of repeated surface plasma resonance. The sensing device is characterized in high detection sensitivity, high modularization degree, simple system, etc.
Description
Technical field
The invention belongs to optical technical field, relate to a kind of surface plasma resonance sensing equipment, particularly a kind of surface plasma resonance sensing system based on high-fineness cavity, the trace materials that is mainly used in fields such as food security, environmental monitoring, biology, chemistry and medical science detects.
Technical background
Surface plasma body resonant vibration (Surface Plasmon Resonance is called for short SPR) is a kind of physical optics phenomenon, is found by Wood at the beginning of last century.The sixties, the method for usefulness excited by visible light surface plasma that Germany scientist Otto and Kretchmann have distinguished independent invention.The eighties, Sweden scientist Liedberg is used for this technology the detection of interaction of biomacromolecules.Afterwards, the surface plasma resonance sensing technology develops rapidly, develops into very useful detection technique.
The surface plasma resonance sensing technology can be widely applied to fields such as food security, environmental monitoring, biology, chemistry and medical science.Mainly use in the food security field and to comprise: the detection of farming, residue of veterinary drug amount, microbial contamination detects detection of biotoxin or the like in the food.In the environmental monitoring field, the surface plasma body resonant vibration detection technique can detect that multiring aromatic hydrocarbon, polychlorinated biphenyl, phenols, alkane, aromatics and heavy metal ion etc. are poisonous a polluter.In biology and association area, biosensor technique based on surface plasma body resonant vibration, by the interaction between analysing biomolecules such as protein-protein, medicine-protein, protein-nucleic acid, the nucleic acid-nucleic acid, obtain the trace concentration and the related properties of respective components.
Because more and more higher to the requirement of detection sensitivity, the high-sensitivity surface plasma resonance sensor-based system becomes one of trace materials measuring technique development trend.Formerly in the technology, have a kind of surface plasmon sensor (referring to Chinese invention patent " Wavelength-modulated polarized surface plasma wave sensor ", the patent No. number: ZL01136673.7).This surface plasma resonance sensor has suitable advantage, but, still exist not enough, be mainly the light beam that is used for measuring and a total reflection take place at sensing element, the surface plasma body resonant vibration absorption signal that causes detector to detect is the signal of measured matter direct action in light beam, so cause detection sensitivity not high, very big detection sensitivity room for promotion arranged.
Summary of the invention
The problem to be solved in the present invention has been to overcome the deficiency of above-mentioned technology formerly, and a kind of high-fineness cavity surface plasma resonance sensing equipment is provided, and has the detection sensitivity height, and degree of modularity height, system are simple, characteristics such as technology is can transplantability strong.
Basic design of the present invention is: with high-fineness cavity absorption spectrum technological thought application surface plasma resonance sensing, on as surface plasma resonance sensing parts prism, to be coated with the highly reflecting films that are complementary with the incident beam wavelength on light beam incident and two faces of light beam outgoing, two high reflectings surface constitute high-fineness cavity.During beam propagation process prism, light beam comes and goes in high-fineness cavity and propagates, and each one side generation surface plasma body resonant vibration that all is coated with metal pattern at prism that comes and goes is used mutually with measured matter, launches reflex time at the high reflecting surface of outgoing, and the part transmittance is all arranged.The detector detecting light beam goes out the light intensity of prism, is that it is highly sensitive to have high detection through light beam after the surface plasma body resonant vibration effect repeatedly, characteristics such as degree of modularity height, system are simple.
Technical solution of the present invention is: comprise LASER Light Source, surface plasmon sensor, photodetector.Surface plasmon sensor is the cylindricality prism, and its xsect is an isosceles triangle, and the bottom surface of surface plasmon sensor is coated with the metallic reflective coating on plane, and central plane is coated with incident highly reflecting films and outgoing highly reflecting films respectively; Incident highly reflecting films and outgoing highly reflecting films are spherical structure.LASER Light Source is arranged on incident highly reflecting films one side, its emission light path along the radial finger of the sphere of incident highly reflecting films to the centre of sphere.Emission light path along LASER Light Source between LASER Light Source and the incident highly reflecting films is disposed with the optoisolator and the polarizer.Outgoing highly reflecting films one side is disposed with analyzer and photoelectric sensor along emitting light path, described emitting light path along the radial finger of the sphere of outgoing highly reflecting films to the centre of sphere.The plane that the exit point that is all-trans of the sphere centre of sphere of incident highly reflecting films, the sphere centre of sphere of outgoing highly reflecting films and metallic reflective coating constitutes is axial vertical with the cylindricality prism, and satisfies
Wherein, R
1Be the radius-of-curvature of the sphere of incident highly reflecting films, R
2Be the radius-of-curvature of the sphere of outgoing highly reflecting films, the L light beam by the incident highly reflecting films through metallic reflective coating propagate into the outgoing highly reflecting films the distance of process.
Described photodetector is a kind of in photodiode, snowslide pipe, the photomultiplier.
The course of work of apparatus of the present invention is that LASER Light Source is sent light beam, through the optoisolator and the polarizer, form county's light beam, incide on the incident highly reflecting films of surface plasmon sensor, segment beam projection back the bottom surface total reflection takes place, folded light beam passes to photodetector through analyzer through the transmission of outgoing highly reflecting films.The linearly polarized light beam plane of polarization of light beam and beam Propagation place plane parallel, incident highly reflecting films and outgoing highly reflecting films are spherical structure, form the high-fineness cavity of the resonance of beam propagation, be the optical stabilization chamber, light beam comes and goes in high-fineness cavity and propagates, during at every turn through the light beam exit facet, the part transmittance is arranged, reach photodetector.Thereby photodetector obtains taking place on the sensing plane intensity of reflected light information of total reflection, changes the light beam wavelength parameter by regulating LASER Light Source, and when resonant wavelength, sensing on the plane plasma resonance takes place, and forms resonance absorbing peak.The total reflection zone takes place be contact measured matter zone.The resonance absorption peak amplitude is relevant with near the substance characteristics in resonant wavelength and total reflection zone, sensing plane, thereby can obtain measured matter information, for example, and refractive index, concentration etc.By changing analyzer analyzing direction, can obtain the surface plasma body resonant vibration absorption peak amplitude of different polarization direction light beam of different light beam exit facet outgoing and the variation of resonant wavelength, thereby can obtain the feature measurement that measured matter influences light beam polarization.
Compared with prior art, advantage of the present invention: 1) have the detection sensitivity height; 2) degree of modularity height, system are simple; 3) meticulous chamber constitutes simply, has only an optical element; 4) simple and stable structure requires low to mechanical positioning; 5) technology is can transplantability strong.
Description of drawings
Fig. 1 is a structural representation of the present invention.
Embodiment
The invention will be further described below in conjunction with drawings and Examples.
A kind of high-fineness cavity surface plasma resonance sensing equipment of present embodiment, concrete structure as shown in Figure 1.
High-fineness cavity surface plasma resonance sensing equipment comprises LASER Light Source 1, surface plasmon sensor 4, photodetector 6.Surface plasmon sensor 4 is the cylindricality prism, and its xsect is an isosceles triangle, and the bottom surface of surface plasmon sensor is coated with the metallic reflective coating 402 on plane, and central plane is coated with incident highly reflecting films 401 and outgoing highly reflecting films 403 respectively; Incident highly reflecting films 401 and outgoing highly reflecting films 403 are spherical structure.LASER Light Source 1 is arranged on incident highly reflecting films 401 1 sides, its emission light path along the radial finger of the sphere of incident highly reflecting films 401 to the centre of sphere.Emission light path along LASER Light Source 1 between LASER Light Source 1 and the incident highly reflecting films 401 is disposed with the optoisolator 2 and the polarizer 3.Outgoing highly reflecting films 403 1 sides are disposed with analyzer 5 and photoelectric sensor 6 along emitting light path, described emitting light path along the radial finger of the sphere of outgoing highly reflecting films 403 to the centre of sphere.The plane that the exit point that is all-trans of the sphere centre of sphere of incident highly reflecting films 401, the sphere centre of sphere of outgoing highly reflecting films 403 and metallic reflective coating 402 constitutes is axial vertical with the cylindricality prism, and satisfies
Wherein, R
1Be the radius-of-curvature of the sphere 401 of incident highly reflecting films, R
2Be the radius-of-curvature of the sphere of outgoing highly reflecting films 403, the L light beam is propagated into the distance of 403 processes of outgoing highly reflecting films through metallic reflective coating 402 by the incident highly reflecting films.
Laser emitting module 1 is a tunable wave length linearly polarized light laser instrument, and the metallic reflective coating 402 of surface plasmon sensor 4 is the gold thin film of 50nm for thickness, and photodetector 6 adopts photomultiplier, and sample is selected alcohols.
The course of work of apparatus of the present invention is that LASER Light Source 1 is sent light beam, through the optoisolator 2 and the polarizer 3, form county's light beam, incide on the incident highly reflecting films 401 of surface plasmon sensor 4, total reflection takes place at metallic reflective coating 402 in segment beam projection back, folded light beam passes to photodetector 6 through analyzer 5 through 403 transmissions of outgoing highly reflecting films.The linearly polarized light beam plane of polarization of light beam and beam Propagation place plane parallel, incident highly reflecting films 401 and outgoing highly reflecting films 403 are spherical structure, form the high-fineness cavity of the resonance of beam propagation, be the optical stabilization chamber, light beam comes and goes in high-fineness cavity and propagates, during at every turn through the light beam exit facet, the part transmittance is arranged, reach photodetector 6.Thereby photodetector 6 obtains taking place on the sensing plane intensity of reflected light information of total reflection, changes the light beam wavelength parameter by regulating LASER Light Source 1, when resonant wavelength, on the metallic reflective coating 402 plasma resonance takes place, and forms resonance absorbing peak.The total reflection zone takes place be contact measured matter zone.The resonance absorption peak amplitude is relevant with near metallic reflective coating 402 substance characteristics with resonant wavelength, thereby can obtain measured matter information, for example, and refractive index, concentration etc.Present embodiment is a measurement of concetration.By changing analyzer analyzing direction, can obtain the surface plasma body resonant vibration absorption peak amplitude of different polarization direction light beam of different light beam exit facet outgoing and the variation of resonant wavelength, thereby obtain the feature measurement that measured matter influences light beam polarization.The detection sensitivity height, degree of modularity height, system are simple.
Claims (2)
1. high-fineness cavity surface plasma resonance sensing equipment, comprise LASER Light Source, surface plasmon sensor, photodetector, it is characterized in that: surface plasmon sensor is the cylindricality prism, its xsect is an isosceles triangle, the bottom surface of surface plasmon sensor is coated with the metallic reflective coating on plane, and central plane is coated with incident highly reflecting films and outgoing highly reflecting films respectively; Incident highly reflecting films and outgoing highly reflecting films are spherical structure;
LASER Light Source is arranged on incident highly reflecting films one side, and to the centre of sphere, the emission light path along LASER Light Source between LASER Light Source and the incident highly reflecting films is disposed with the optoisolator and the polarizer to its emission light path along the radial finger of the sphere of incident highly reflecting films;
Outgoing highly reflecting films one side is disposed with analyzer and photoelectric sensor along emitting light path, and described emitting light path radially points to sphere by the centre of sphere of outgoing highly reflecting films;
The plane that the exit point that is all-trans of the sphere centre of sphere of incident highly reflecting films, the sphere centre of sphere of outgoing highly reflecting films and metallic reflective coating constitutes is axial vertical with the cylindricality prism, and satisfies
Wherein, R
1Be the radius-of-curvature of the sphere of incident highly reflecting films, R
2Be the radius-of-curvature of the sphere of outgoing highly reflecting films, L by light beam by the incident highly reflecting films through metallic reflective coating propagate into the outgoing highly reflecting films the distance of process.
2. high-fineness cavity surface plasma resonance sensing equipment as claimed in claim 1 is characterized in that: described photodetector is a kind of in photodiode, snowslide pipe, the photomultiplier.
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| CN 200810061917 CN101294900B (en) | 2008-05-27 | 2008-05-27 | High-fineness cavity surface plasma resonance sensing equipment |
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| CN 200810061917 CN101294900B (en) | 2008-05-27 | 2008-05-27 | High-fineness cavity surface plasma resonance sensing equipment |
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| CN101294900B true CN101294900B (en) | 2011-08-24 |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101865840A (en) * | 2010-06-07 | 2010-10-20 | 深圳国际旅行卫生保健中心 | Surface plasmon resonance imaging sensing system |
| CN105486665B (en) * | 2016-01-26 | 2018-07-31 | 深圳大学 | A kind of SPR detection methods |
| CN108982365B (en) * | 2016-08-30 | 2021-03-26 | 上海理工大学 | Optical field traveling wave cavity enhanced surface plasma resonance sensing device |
| CN106442955B (en) * | 2016-11-09 | 2023-05-16 | 苏州一呼医疗科技有限公司 | Reflective optical detection device of intelligent expiration molecular diagnosis system |
| CN106855511A (en) * | 2016-12-07 | 2017-06-16 | 大连理工大学 | High sensitivity infrared band surface plasmon resonance biosensor |
| CN109539998A (en) * | 2018-12-05 | 2019-03-29 | 陕西理工大学 | A kind of nanometer gap measuring device and method based on light-intensity test |
| CN115308162B (en) * | 2021-05-07 | 2024-07-26 | 清华大学深圳国际研究生院 | Optical weak measurement refractive index biosensing system and molecular interaction detection method |
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