CN108982365B - Optical field traveling wave cavity enhanced surface plasma resonance sensing device - Google Patents
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Abstract
The invention provides an optical field traveling wave cavity enhanced surface plasmon resonance sensing device, which is characterized by comprising the following components: a frequency tunable light source; the polygonal prism unit comprises a regular polygonal prism with at least five sides, and metal layers, nanoparticle layers and micro-nano optical structure layers which are sequentially arranged on the outer sides of different edges of the regular polygonal prism; and the optical information receiving unit, wherein the tested sample is placed on the outer side of the metal layer, the nanoparticle layer is of a core-shell structure and used for enhancing Raman sensing of the tested sample, the core-shell structure comprises a gold nanolayer and a silicon dioxide nanolayer, and the micro-nano optical structure layer is used for super-resolution image sensing. Therefore, the resonance sensing device has the advantages of simple system structure, uniform light field intensity distribution, high sensitivity, high system stability and the like, and has the characteristics of multi-mechanism sensing detection, capability of realizing regional measurement, easiness in function expansion, wide application range and the like.
Description
The application is a divisional application of patent application with the application number of CN201610776956.X, the application date of 2016, 08, 30, the publication date of 2017, 01, 18, the publication number of CN106338470A, and the invention name of "an optical field traveling wave cavity enhanced surface plasmon resonance sensing device".
Technical Field
The invention belongs to the technical field of optical detection, and particularly relates to an optical field traveling wave cavity enhanced surface plasmon resonance sensing device.
Background
The surface plasma resonance sensing technology is developed rapidly, is widely applied to various fields of material analysis, environment detection, environment perception, food safety, life science, biomedicine, medical diagnosis, security protection, criminal investigation, quality inspection, process control and the like, and becomes one of the development hotspots of the trace material measurement and analysis technology, but the existing surface plasma resonance sensing technology has many defects.
The chinese invention patent (application No. CN01136673.7, publication No. CN 1342895) discloses a wavelength modulation polarization type surface plasma wave sensor, which includes a laser, a polarizer, a sensing component, a 1/4 wave plate, an analyzer, a photoelectric converter, a lock-in amplifier, a computer, and a signal generator. Although the wavelength modulation polarization type surface plasma wave sensor has the advantages of simple structure, obvious improvement on the measurement resolution and the like, the light beam is totally reflected once in the sensing component, so that the measurement sensitivity is not high.
In order to overcome the defects of the wavelength modulation polarization type surface plasma wave sensor, the Chinese invention patent (with the publication number of CN 101294900) discloses a high-fineness cavity surface plasma resonance sensor which comprises a laser source, a surface plasma sensor and a photoelectric detector, wherein the surface plasma sensor is a cylindrical prism with an isosceles triangle section, the inclined side surfaces are a light beam incident surface and a light beam emergent surface, the bottom side surface is a sensing plane and is provided with a metal film, an incident light beam is vertical to the light beam incident surface, an emergent light beam is vertical to the light beam emergent surface, and the light beam is totally reflected on the sensing plane after entering the surface plasma sensor; the light beam incidence surface and the light beam emergence surface form a high-fineness cavity; the light beam is transmitted back and forth in the high-fineness cavity, surface plasma resonance occurs on one surface of the prism coated with the metal film every time of back and forth transmission, and the light beam and the measured substance interact with each other. Although the high-fineness cavity surface plasma resonance sensor has certain advantages, the intrinsic deficiency still exists, the high-fineness cavity is formed by two planes of the isosceles prism, the cavity is a linear high-fineness cavity, a light field is transmitted back and forth inside, standing wave behaviors exist, the intensity distribution of the light field is uneven, the sensitivity of the device and the anti-interference performance of a system are affected, and meanwhile, the sensing capability of the device in the prior art is limited, multi-mechanism sensing detection cannot be realized, and the application range is affected.
Disclosure of Invention
The present invention is made to solve the above problems, and an object of the present invention is to provide an optical field traveling wave cavity enhanced surface plasmon resonance sensing apparatus having an annular cavity structure, a simple system structure, excitation by a traveling wave optical field, uniform optical field intensity distribution, high sensitivity, high system stability, multiple mechanical sensing detection, capability of realizing area measurement, easily expanded functions, and a wide application range.
The technical scheme adopted by the invention is as follows:
the invention provides an optical field traveling wave cavity enhanced surface plasmon resonance sensing device, which is used for detecting the material information of a tested sample and has the characteristics that: the frequency-adjustable light source is used for emitting light beams with various single frequencies, and the frequency-adjustable light source is a tunable laser or a multi-wavelength laser; the polygonal prism unit comprises a regular polygonal prism with at least five sides, and metal layers, nanoparticle layers and micro-nano optical structure layers which are sequentially arranged on the outer sides of different edges of the regular polygonal prism; the light beam coupler is arranged on the outer side of the edge of the regular polygon prism and used for coupling light beams, and the light beam coupler is any one of a prism light beam coupler, a grating light beam coupler and a micro-nano structure light beam coupler; and an optical information receiving unit for receiving an information optical field with optical information of a sample to be detected, which is emitted from the regular polygon prism, wherein the optical information receiving unit is any one of a photodiode, a photomultiplier tube and an avalanche diode, the material information is refractive index, concentration and intermolecular force, the sample to be detected is placed on the outer side of the metal layer, the nanoparticle of the nanoparticle layer is a core-shell structure for enhancing Raman sensing of the sample to be detected, the core-shell structure comprises a gold nanoparticle layer and a silica nanoparticle layer wrapped outside the gold nanoparticle layer, the micro-nano optical structure layer is used for generating super-resolution image sensing and is a micro-nano column array or a micro-nano hole array, the incident direction of a light beam is vertical to the axial direction of the regular polygon prism, and the light beam is coupled into the regular polygon prism through the side of the regular polygon prism provided with a light beam coupler, the light beams are totally reflected on the metal layer, the nano particle layer and the micro-nano optical structure layer.
The optical field traveling wave cavity enhanced surface plasmon resonance sensing device provided by the invention also has the following characteristics: wherein, the metal layer is a gold film.
The optical field traveling wave cavity enhanced surface plasmon resonance sensing device provided by the invention also has the following characteristics: wherein, regular polygon prism is regular hexagon prism.
Action and Effect of the invention
According to the optical field traveling wave cavity enhanced surface plasmon resonance sensing device, because light beams emitted by the frequency-adjustable light source can be incident on one edge of the regular polygon prism, total reflection is carried out on the inner sides of different edges of the regular polygon prism, an inner traveling wave optical field of the regular polygon prism is formed, the inner traveling wave optical field and metal layers, nanoparticle layers and micro-nano optical structure layers on the outer sides of the different edges of the regular polygon prism respectively act to obtain an information optical field, and the information optical field is finally received by the optical information receiving unit and is processed and analyzed to obtain material information of a detected sample. Therefore, the optical field traveling wave cavity enhanced surface plasmon resonance sensing device has the advantages of simple system structure, uniform optical field intensity distribution, high sensitivity, high system stability and the like, and has the characteristics of multi-mechanism sensing detection, capability of realizing regional measurement, easiness in function expansion, wide application range and the like.
Drawings
Fig. 1 is a schematic structural diagram of an optical field traveling wave cavity enhanced surface plasmon resonance sensing apparatus according to an embodiment of the present invention.
Detailed Description
In order to make the technical means, the creation features, the achievement purposes and the effects of the invention easy to understand, the following embodiments are combined with the accompanying drawings to specifically describe the optical field traveling wave cavity enhanced surface plasmon resonance sensing device of the invention.
Fig. 1 is a schematic structural diagram of an optical field traveling wave cavity enhanced surface plasmon resonance sensing apparatus according to an embodiment of the present invention.
As shown in fig. 1, in the present embodiment, the optical field traveling wave cavity-enhanced surface plasmon resonance sensing apparatus 100 is used for detecting parameters such as refractive index, concentration and intermolecular force of macromolecular protein substances, and includes a frequency-tunable light source 10, a beam coupler 20, a polygonal prism unit 30 and an optical information receiving unit 40.
The frequency tunable light source 10 is used to emit a light beam of a single frequency, the frequency of which can be tuned, and in this embodiment, the frequency tunable light source 10 is a tunable laser 10. Further, the frequency tunable light source 10 may be a multi-wavelength laser.
The beam coupler 20 is disposed on one side surface of the polygonal prism unit 30, and the light beam emitted from the tunable laser 10 is irradiated on the beam coupler 20 and coupled to the polygonal prism unit 30 through the beam coupler 20, in this embodiment, the beam coupler 20 is a prism beam coupler 20. In addition, the beam coupler 20 may also be a grating beam coupler or a micro-nano structure beam coupler.
The polygonal prism unit 30 includes a regular polygonal prism 31 with at least five sides, and a metal layer 32, a nanoparticle layer 33 and a micro-nano optical structure layer 34 sequentially disposed on the outer sides of different edges of the regular polygonal prism 31, in this embodiment, the polygonal prism unit 30 is the regular hexagonal prism 31.
The cross section of regular hexagonal prism 31 has first edge 311, second edge 312, third edge 313, fourth edge 314, fifth edge 315, and sixth edge 316. The incident direction of the light beam is perpendicular to the axial direction of the regular hexagonal prism 31, and the light beam is coupled into the regular hexagonal prism 31 from the side where the first edge 311 is located by the prism beam coupler 20.
The metal layer 32 is attached to the side where the second edge 312 is located, a sensing area is formed below the second edge 312, the macromolecular protein substance is placed on the metal layer 32, when the light beam irradiates on the metal layer 32, the light beam and the macromolecular protein substance are acted, surface plasma resonance sensing is achieved, total reflection of the light beam occurs on the metal layer 32, and in the embodiment, the metal layer 32 is a 50nm gold film 32.
The nanoparticle layer 33 is attached to the side where the third edge 313 is located, the nanoparticle layer 33 is of a core-shell structure, the core-shell structure comprises a gold nanolayer and a silicon dioxide nanolayer wrapped outside the gold nanolayer, light beams enter the third edge 313 after being totally reflected on the gold film 32, the nanoparticle layer 33 on the third edge 313 is totally reflected, meanwhile, laser Raman excitation is formed on the nanoparticle layer 33, and Raman signals of macromolecular protein substances are enhanced. The enhanced signal is collected by an external detection component.
The micro-nano optical structure layer 34 is attached to the side face where the fourth edge 314 is located, light beams with macromolecular protein substance optical information enter the fourth edge 314 after being totally reflected on the nano particle layer 33, the light beams are totally reflected on the micro-nano optical structure layer 34, meanwhile, a light field scale compression effect occurs on the micro-nano optical structure layer 34, super-diffraction limit light spots are obtained, super-resolution image sensing is achieved, and sensed information is collected by an external detection component. In the present embodiment, the micro-nano optical structure layer 34 is a micro-nano column array 34. In addition, the micro-nano optical structure layer 34 may also be a micro-nano hole array.
The light beam with the optical information of the macromolecular protein substance totally reflects on the micro-nano column array 34 and then sequentially reaches the side where the fifth edge 315 and the sixth edge 316 are located, and respectively returns to the side where the first edge 311 is located after totally reflecting. Meanwhile, the light beam with the macromolecular protein substance optical information is subjected to near-field region spectral absorption method sensing on the side faces of the fifth edge 315 and the sixth edge 316, and finally, an information light field with the macromolecular protein substance optical information is obtained.
The light information receiving unit 40 is used for receiving the information light field with the macromolecular protein substance light information emitted from the regular hexagonal prism. In the present embodiment, the optical information receiving unit 40 is a photodiode 40. Further, the optical information receiving unit 40 may also be a photomultiplier or an avalanche diode.
The working process of the optical field traveling wave cavity enhanced surface plasmon resonance sensing device 100 according to the present embodiment is as follows:
firstly, placing the detected macromolecular protein substance on a gold film 32; then, the light beam emitted by the tunable laser 10 is coupled into the regular hexagonal prism 31 through the prism light beam coupler 20, and after being refracted at the side where the first edge 311 is located, the light beam reaches the side where the second edge 312 is located, and is totally reflected on the gold film 32 to interact with the macromolecular protein substance on the gold film 32, so that the surface plasmon resonance sensing is realized; further, the light beam with the optical information of the macromolecular protein substance reaches the side where the third edge 313 is located, is totally reflected on the nanoparticle layer 33, and forms laser raman excitation with the nanoparticle layer 33 to realize enhancement of raman signals; further, the enhanced light beam enters the side where the fourth edge 314 is located, is totally reflected on the micro-nano column array 34, and generates a light field scale compression effect with the micro-nano column array 34, so that super-resolution image sensing is realized; furthermore, the light beam enters the side surface where the fifth edge 315 is located, and is totally reflected, so that the sensing by the spectral absorption method is realized; then, the light beam enters the side where the sixth edge 316 is located, and is totally reflected, so that the spectral absorption method sensing is realized, and finally, an information light field with macromolecular protein substance light information is obtained, and then, the information light field returns to the first edge 311, is coupled through the prism light beam coupler 20 on the side where the first edge 311 is located, and is received through the photodiode 40. In the measurement process, the frequency of the tunable laser 10 is changed to excite and collect multi-wavelength related information, and finally, the refractive index, concentration, intermolecular force and other substance information of the macromolecular protein substance are obtained through computer analysis and processing.
Effects and effects of the embodiments
According to the optical field traveling wave cavity enhanced surface plasmon resonance sensing device related to the embodiment, because the light beam emitted by the tunable laser can be incident on one edge of the regular hexagonal prism, the light beam is totally reflected on the inner sides of different edges of the regular hexagonal prism to form the traveling wave optical field in the regular hexagonal prism, and the traveling wave optical field acts on the gold film, the nanoparticle layer and the micro-nano column array on the outer sides of the different edges of the regular hexagonal prism respectively to obtain an information optical field, wherein the information optical field is finally received by the photodiode, and material information such as the refractive index, the concentration and the intermolecular acting force of macromolecular protein substances is obtained after the information optical field is processed and analyzed by a computer. Therefore, the optical field traveling wave cavity enhanced surface plasmon resonance sensing device of the embodiment not only has the advantages of simple system structure, uniform optical field intensity distribution, high sensitivity, high system stability and the like, but also has the characteristics of multi-mechanism sensing detection, realization of regional measurement, easy function expansion, wide application range and the like.
The above embodiments are preferred examples of the present invention, and are not intended to limit the scope of the present invention.
Claims (3)
1. An optical field traveling wave cavity enhanced surface plasmon resonance sensing device for detecting material information of a detected sample, comprising:
the frequency-adjustable light source is used for emitting light beams with various single frequencies, and the frequency-adjustable light source is a tunable laser or a multi-wavelength laser; the polygonal prism unit comprises a regular polygonal prism with at least five edges, and metal layers, nanoparticle layers and micro-nano optical structure layers which are sequentially arranged on the outer sides of different edges of the regular polygonal prism; the light beam coupler is arranged on the outer side of the edge of the regular polygon prism and used for coupling the light beam, and the light beam coupler is any one of a prism light beam coupler, a grating light beam coupler and a micro-nano structure light beam coupler; and a light information receiving unit for receiving an information light field with the light information of the sample to be measured emitted from the regular polygon prism, wherein the light information receiving unit is any one of a photodiode, a photomultiplier tube and an avalanche diode,
wherein the substance information is refractive index, concentration and intermolecular force,
the tested sample is placed on the outer side of the metal layer,
the nano particles of the nano particle layer are of a core-shell structure and are used for enhancing the Raman sensing of the detected sample, the core-shell structure comprises a gold nano layer and a silicon dioxide nano layer wrapped outside the gold nano layer,
the micro-nano optical structure layer is used for generating super-resolution image sensing and is a micro-nano column array or a micro-nano hole array,
the incident direction of the light beam is perpendicular to the axial direction of the regular polygon prism,
the light beam is coupled into the regular polygon prism through the side of the regular polygon prism provided with the light beam coupler,
and the light beams are totally reflected on the metal layer, the nano particle layer and the micro-nano optical structure layer.
2. The optical field traveling wave cavity enhanced surface plasmon resonance sensing apparatus of claim 1, wherein:
wherein, the metal layer is a gold film.
3. The optical field traveling wave cavity enhanced surface plasmon resonance sensing apparatus of claim 1, wherein:
the regular polygon prism is a regular hexagon prism.
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| CN109238964B (en) | 2020-12-01 |
| CN109238964A (en) | 2019-01-18 |
| CN106338470A (en) | 2017-01-18 |
| CN106338470B (en) | 2019-01-01 |
| CN108982365A (en) | 2018-12-11 |
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