CN101843663A - 一种比水重的挥发油提取包裹制备方法 - Google Patents
一种比水重的挥发油提取包裹制备方法 Download PDFInfo
- Publication number
- CN101843663A CN101843663A CN201010178094A CN201010178094A CN101843663A CN 101843663 A CN101843663 A CN 101843663A CN 201010178094 A CN201010178094 A CN 201010178094A CN 201010178094 A CN201010178094 A CN 201010178094A CN 101843663 A CN101843663 A CN 101843663A
- Authority
- CN
- China
- Prior art keywords
- volatile oil
- betacyclodextrin
- distillate
- water
- package
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000341 volatile oil Substances 0.000 title claims abstract description 107
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 239000000284 extract Substances 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 54
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 50
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 50
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 50
- 229960004853 betadex Drugs 0.000 claims abstract description 50
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000003921 oil Substances 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 239000000243 solution Substances 0.000 claims description 27
- 238000003756 stirring Methods 0.000 claims description 20
- 238000004321 preservation Methods 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 14
- 239000012567 medical material Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000012047 saturated solution Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 11
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000000926 separation method Methods 0.000 abstract description 4
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract description 2
- 238000009938 salting Methods 0.000 abstract 3
- 230000009286 beneficial effect Effects 0.000 abstract 1
- 238000004945 emulsification Methods 0.000 abstract 1
- 238000004806 packaging method and process Methods 0.000 abstract 1
- 238000005057 refrigeration Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000000605 extraction Methods 0.000 description 10
- 235000019198 oils Nutrition 0.000 description 8
- 230000000694 effects Effects 0.000 description 5
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 4
- 229940117916 cinnamic aldehyde Drugs 0.000 description 4
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 244000080208 Canella winterana Species 0.000 description 1
- 235000008499 Canella winterana Nutrition 0.000 description 1
- 235000021511 Cinnamomum cassia Nutrition 0.000 description 1
- 208000008454 Hyperhidrosis Diseases 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000000146 antalgic effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 125000002871 cinnamic aldehydes group Chemical group 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000019476 oil-water mixture Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 239000011265 semifinished product Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010101780943A CN101843663B (zh) | 2010-05-20 | 2010-05-20 | 一种比水重的挥发油提取包裹制备方法 |
Applications Claiming Priority (1)
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---|---|---|---|
CN2010101780943A CN101843663B (zh) | 2010-05-20 | 2010-05-20 | 一种比水重的挥发油提取包裹制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN101843663A true CN101843663A (zh) | 2010-09-29 |
CN101843663B CN101843663B (zh) | 2013-04-17 |
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CN2010101780943A Active CN101843663B (zh) | 2010-05-20 | 2010-05-20 | 一种比水重的挥发油提取包裹制备方法 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274505A (zh) * | 2014-10-21 | 2015-01-14 | 湖北襄阳隆中药业集团有限公司 | 一种独活止痛搽剂的制备方法 |
CN105287963A (zh) * | 2015-11-25 | 2016-02-03 | 葵花药业集团(襄阳)隆中有限公司 | 一种克感利咽颗粒的制备方法 |
CN106281698A (zh) * | 2016-08-16 | 2017-01-04 | 江苏康缘药业股份有限公司 | 一种桂枝挥发油的提取精制方法 |
CN116850247A (zh) * | 2023-08-14 | 2023-10-10 | 赵汝君 | 一种治疗高尿酸血和痛风的中药组合物制备方法及组合物 |
-
2010
- 2010-05-20 CN CN2010101780943A patent/CN101843663B/zh active Active
Non-Patent Citations (3)
Title |
---|
《中成药》 19991231 张玲等 肉桂挥发油beta-环糊精包合工艺的研究 561,562 1 第21卷, 第11期 * |
《中成药》 19991231 张玲等 肉桂挥发油beta-环糊精包合工艺的研究 561,562 1 第21卷, 第11期 2 * |
张玲等: "肉桂挥发油β-环糊精包合工艺的研究", 《中成药》 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104274505A (zh) * | 2014-10-21 | 2015-01-14 | 湖北襄阳隆中药业集团有限公司 | 一种独活止痛搽剂的制备方法 |
CN105287963A (zh) * | 2015-11-25 | 2016-02-03 | 葵花药业集团(襄阳)隆中有限公司 | 一种克感利咽颗粒的制备方法 |
CN106281698A (zh) * | 2016-08-16 | 2017-01-04 | 江苏康缘药业股份有限公司 | 一种桂枝挥发油的提取精制方法 |
CN106281698B (zh) * | 2016-08-16 | 2019-11-01 | 江苏康缘药业股份有限公司 | 一种桂枝挥发油的提取精制方法 |
CN116850247A (zh) * | 2023-08-14 | 2023-10-10 | 赵汝君 | 一种治疗高尿酸血和痛风的中药组合物制备方法及组合物 |
Also Published As
Publication number | Publication date |
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CN101843663B (zh) | 2013-04-17 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
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Denomination of invention: Preparation method of extract package of volatile oil heavier than water Effective date of registration: 20190729 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: 2019450000034 |
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Date of cancellation: 20200826 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: 2019450000034 |
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Denomination of invention: A method of extracting and wrapping volatile oil with specific water weight Effective date of registration: 20200925 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2020450000037 |
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Date of cancellation: 20210918 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2020450000037 |
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Denomination of invention: A preparation method of volatile oil extraction package with specific weight of water Effective date of registration: 20211012 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2021450000043 |
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Date of cancellation: 20221102 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2021450000043 |
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Denomination of invention: A method of extracting and wrapping volatile oil with specific weight of water Effective date of registration: 20221210 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2022450000222 |
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Date of cancellation: 20231113 Granted publication date: 20130417 Pledgee: Nanning United Innovation Venture Capital Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2022450000222 |
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Denomination of invention: A method for preparing volatile oil extraction packages that are heavier than water Effective date of registration: 20231214 Granted publication date: 20130417 Pledgee: Guangxi SME Financing Guarantee Co.,Ltd. Pledgor: PURA (NANNING) PHARMACEUTICAL Co.,Ltd. Registration number: Y2023450000147 |
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