CN101842166A - 用于不均匀性聚焦的装置 - Google Patents

用于不均匀性聚焦的装置 Download PDF

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CN101842166A
CN101842166A CN200880113520A CN200880113520A CN101842166A CN 101842166 A CN101842166 A CN 101842166A CN 200880113520 A CN200880113520 A CN 200880113520A CN 200880113520 A CN200880113520 A CN 200880113520A CN 101842166 A CN101842166 A CN 101842166A
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CN101842166B (zh
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布鲁斯·H·金
史蒂文·巴里·伍尔夫森
大卫·H·拉马希
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    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05KPRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K3/00Apparatus or processes for manufacturing printed circuits
    • H05K3/10Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern
    • H05K3/12Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns
    • H05K3/1241Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns by ink-jet printing or drawing by dispensing
    • H05K3/125Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns by ink-jet printing or drawing by dispensing by ink-jet printing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02Spray pistols; Apparatus for discharge
    • B05B7/025Nozzles having elongated outlets, e.g. slots, for the material to be sprayed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
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    • B05B7/0475Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
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    • B05SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
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    • H05K3/10Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern
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    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B12/00Arrangements for controlling delivery; Arrangements for controlling the spray area
    • B05B12/16Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling the spray area
    • B05B12/18Arrangements for controlling delivery; Arrangements for controlling the spray area for controlling the spray area using fluids, e.g. gas streams
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    • B05BSPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
    • B05B7/00Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
    • B05B7/02Spray pistols; Apparatus for discharge
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    • B05B7/0884Spray pistols; Apparatus for discharge with separate outlet orifices, e.g. to form parallel jets, i.e. the axis of the jets being parallel, to form intersecting jets, i.e. the axis of the jets converging but not necessarily intersecting at a point the outlet orifices for jets constituted by a liquid or a mixture containing a liquid being aligned
    • HELECTRICITY
    • H05ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05KPRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K2203/00Indexing scheme relating to apparatus or processes for manufacturing printed circuits covered by H05K3/00
    • H05K2203/01Tools for processing; Objects used during processing
    • H05K2203/0104Tools for processing; Objects used during processing for patterning or coating
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  • Chemical Vapour Deposition (AREA)
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Abstract

一种用于沉积物质的基本上平面型的组件。所述组件包括板,所述板当组装时限定至少一个气溶胶通道、包覆气体喷混室和喷嘴。这些组件优选是不均匀性的,并且优选是矩形。气溶胶通道可以进一步分隔以改善气溶胶流动的均匀性。

Description

用于不均匀性聚焦的装置
相关申请的交叉引用
本申请要求2007年8月31日提交的名称为“用于不均匀性聚焦的装置(Apparatus for Anisotropic Focusing)”的美国临时专利申请序列60/969,445的申请日的权益,该美国临时专利申请的说明书通过引用结合在此。
发明背景
发明领域(技术领域):
本发明涉及使用不对称尖端几何结构的物质流的不均匀性聚焦的领域。
相关技术描述:
现有技术通常涉及使用空气动力学聚焦的用于液体和液体-粒子悬浮体的高分辨率、无掩模沉积的装置和方法。在最通常使用的实施方案中,将气溶胶流聚焦并且沉积到平面型或非平面型的目标上,从而形成图案,将该图案热处理或光化学处理以实现接近对应的本体物质的物理、光学和/或电性质的这些性质。该方法称为
Figure GPA00001115626300011
(无掩模中尺度物质沉积(MasklessMesoscale Material Deposition))技术,并且被用于沉积线宽的数量级比使用常规厚膜法沉积的线宽小的气溶胶化物质。沉积是在不使用掩模的条件下进行的。另外,
Figure GPA00001115626300012
方法能够限定宽度小于1微米的线。
Figure GPA00001115626300013
装置优选使用气溶胶喷射沉积头以形成环状传播射流,所述射流包括外部的包覆(sheath)流和内部的负载气溶胶的载体流。在环状气溶胶喷射法中,气溶胶流进入沉积头,优选在气溶胶化过程之后直接进入或在经过加热器组件之后进入,并且沿设备的轴引导至沉积头孔口。质量输出量优选通过气溶胶载气质量流控制器控制。在沉积头内部,气溶胶流优选通过经过毫米大小的孔口初始对准。然后优选将射出(emergent)的粒子流与环状包覆气体合并,所述环状包覆气体起到消除喷嘴的堵塞并且聚焦气溶胶流的作用。载气和包覆气体最通常地包括压缩空气或惰性气体,其中一种或两种可以含有变化的溶剂蒸气含量。例如,当气溶胶由水溶液形成时,可以将水蒸汽加入到载气或包覆气体中以防止液滴挥发。
包覆气体优选通过气溶胶入口下面的包覆空气入口进入并且与气溶胶流形成环状流。与气溶胶载气的情况相同,包覆气体流量优选通过质量流控制器控制。合并流以高速(~50m/s)通过对准目标的孔口离开喷嘴,并且随后冲击到目标上。此环状流将气溶胶流聚焦到目标上并且允许具有尺寸小于约1微米的特征的沉积。图案是通过相对于目标移动沉积头形成的。
涉及M3D方法的现有技术公开了通常使用同轴包覆流技术的装置。图1显示同心管的最简单的几何结构。最内部的雾管10运送气溶胶雾流中的雾化物质。管10与外壳12同心地安装在组件16的近端位置14处。雾管10和外壳12之间的环状空间形成同轴包覆室18。包覆气体在近端位置20处进入包覆室18使得在包覆气体移动了包覆室18的长度的时间之前,气体已经建立了与雾流同轴的充分发展的层流。雾和包覆流在发生流体动力学聚焦的会聚区22中相遇。会聚区22的远端锥体24提供额外的几何聚焦。尖端26可以加入到组件16中以提供额外的几何聚焦。
液体流式细胞计也利用流体动力学聚焦将样品流构成典型地要光学分析的极细的线。与气溶胶和气体包覆M3D法不同,流动流式细胞计仅采用液体,因此受益于液体和用于聚焦样品物质的层流的不可压缩性。液体样品(典型地预先处理的血液样品,类似于
Figure GPA00001115626300021
方法中的气溶胶流)由液体包覆体(sheath)聚焦,该液体包覆体典型地为去离子水或盐水溶液。典型地,液体样品被聚焦至约10微米宽,以使感兴趣的生物细胞几乎依次排列。这些细胞从聚焦室直接进入光学透明且典型正方形的管,所述管具有约250平方微米的内部正方形室。正方形流动池不用于额外地聚焦细胞。在一些情况下,引导激光通过流动池的一个表面,并且光学检测器与激光相对安置,并且垂直于激光,以检测当激光束穿过聚焦的样品流时反射和折射的光。由于样品基本上为顺序排列的细胞,可以分析改变的光图案并且可以检测和计数不同的细胞。另外,然后可以使用特别设备将细胞的流分类并且沉积到独立的室中。聚焦和光学室(典型地称为“流动池”)的构造对于流式细胞计的公众是熟知的并且缺点在于聚焦室与光学室的进口难于对齐;另外的缺点在于高成本。在大部分应用中,这些流动池必须再次洗涤并再次使用,而非丢弃。再次使用的缺点是明显的:交叉污染和浪费时间。还已知流式细胞计尺寸较大,以及其必须泵送、阀控(valve)和计量各种流的复杂性。当处置潜在有害的生物流体时,装载、卸载和运行这些设备可能是极为困难且有害的。
一次性平面型液体处置组件也是流式细胞计领域熟知的,如在专利6,537,501中示例的。并非具有许多管和独立的阀门,而是可利用使用许多典型为塑料材料的薄层的小的液体处置盒。每一层可以具有不同的流体路径的室或仅为将一个通道与另一个通道分隔的阻挡层。当适当取向和组装时,建立流体可以从一层流到另一层的流体“线路板”。采用这种层状途径,2-维聚焦室被用于将样品流体聚焦到光学室中。
发明简述
本发明是物质沉积组件,其包含第一盖板和第二盖板,盖板中的一个或两个包括用于含物质的气溶胶的入口和一个或多个包覆气体入口;在盖板之间密封的插入件,所述插入件包括至少一个与气溶胶入口和不均匀性喷嘴流体连接的气溶胶通道;其中所述一个或多个包覆气体入口与包覆体喷混室(plenum)流体连接,所述包覆体喷混室包封至少一个气溶胶通道的出口和喷嘴的进口。插入件优选包括两个镜像板,其在组装到一起时形成气溶胶通道和喷嘴。包覆气体优选将包覆体喷混室和喷嘴中的气溶胶包围和聚焦。包覆体喷混室优选为不均匀性的。喷嘴优选为矩形,气溶胶通道优选为矩形并且优选与矩形喷嘴对齐。喷嘴优选可在物质沉积过程中相对于基底移动,并且任选地可相对于喷嘴和基底的相对移动方向倾斜。沉积组件优选还包括连接一个或多个包覆气体入口和包覆体喷混室的通道,构造通道使得包覆气体进入包覆体喷混室从而在基本上平行于气溶胶在气溶胶通道中的流动方向的方向上移动。
插入件任选地包括包含气溶胶通道的尖端垫片。尖端垫片优选可变形,并且尖端垫片的变形优选改变气溶胶通道的尖端的宽度。
所述至少一个气溶胶通道的至少一部分任选地包括交替偏置的间隔体或任选地再分隔成多个更小的次通道。次通道优选轴向对齐并且排列成两排,第一排中的次通道偏移第二排中的次通道。第一排中的次通道任选地相对于第二排中的次通道形成角度,在这种情况下,在相邻次通道中的各个气溶胶流优选在离开气溶胶通道时交叉。
本发明的目的、优点和新的特征,以及适用性的进一步范围部分将在后面的详述部分中结合附图描述,对于本领域技术人员,部分地,将通过以下内容的阅读变得明显,或可以通过本发明的实施而知晓。本发明的目的和优点可以通过特别在后附权利要求书中指出的手段和组合而实现和获得。
附图说明
结合到说明书中并且形成说明书的一部分的附图示出本发明的一个或多个实施方案,并且与描述一起起到解释本发明的原理的作用。附图仅为了示出本发明的一个或多个优选实施方案的目的并且不应理解为限制本发明。在附图中:
图1是使用同心管的现有技术纳米沉积头的示意图;
图2是具有矩形喷嘴构造的平面型组件的分解图示意图;
图3是不含管的平面型组件的示意图;
图4是不含管的平面型组件的另一个实施方案的示意图;
图5是解释层流曲线的图;
图6是显示由图5中所示流动曲线产生的沉积图案的图;
图7是解释流动矫直的图;
图8是显示靠近在一起的许多小的层流图案的图;
图9是显示雾通道内多个正方形几何通道的示意图;
图10是显示具有与图9不同的几何结构的雾通道内多个通道的示意图;和
图11是显示具有与图9和图10不同的几何结构的雾通道内多个通道的示意图。
发明详述
本发明涉及使用不对称喷嘴几何结构的用于物质流的不均匀性聚焦的装置和方法。一种构造这样设备的直接方法是挤出两个同轴的矩形管;将它们类似于图1的同心管构造组装,然后连接也与图1中所示设计类似的较小的矩形尖端管。本发明优选采用平面型组件,其提供在通道设计方面的巨大灵活性并且使得可以构造使用普通雾(common mist)的聚焦喷嘴的阵列;包覆体喷混室和废物喷混室。矩形喷嘴仅是可用于这些平面型组件的尖端几何结构的一个实例。
图2显示表现出不均匀性聚焦的矩形喷嘴平面型组件的一个实施方案的分解图。全部四层优选用安置在两个对准孔28中的接合销对齐。所述层优选经由孔30中的六个螺丝钉在仅使用挤压的情况下被密封在一起。为了使挤压密封起作用,所有的啮合表面必须良好地进行精整并且优选抛光。备选地,如果目标能够在挤压的过程中表现出一些变形,例如高硬度塑料基底,则大部分微小缺陷和刮痕将被周围的变形材料密封。使用过软基底的风险在于将组件密封所需的挤压可能显著地影响喷嘴的几何形状。可以备选地采用任何其它密封组件的方法,包括但不限于垫圈和/或粘合剂。
气溶胶雾通过雾口(mist port)32进入组件。包覆气体通过包覆体口34进入组件。有两个相同的雾通道板36和38,它们当以图3中详述的镜像结构(mirrored configuration)组装时形成矩形雾通道52。顶板40相对于雾通道板36的表面42密封。底板44相对于雾通道板38的背表面(在图2中不可见)密封。在图3中,当将顶板和底板40和44(在图3中未显示)组装时,围绕雾通道52的各个侧面54、顶部56和底部(不可见)形成包覆体喷混室。会聚区58是具有大部分不均匀性流体动力学聚焦的区域。不均匀性几何聚焦发生在图2中所示的区域48中。所述流在尖端50处离开喷嘴。
矩形尖端可用于诸如共形涂布之类的应用,因为其提供宽且扁平的喷雾图案。此尖端不对称地聚焦雾,从而在头在垂直于较长边的方向上移动的条件下提供较宽的线宽,而在头在垂直于较短边的方向上移动的条件下提供较窄的线宽。后一种图案将产生增加的沉积厚度,原因在于其在其自身上沉积较多的物质。对于以类似方式使用的多喷嘴沉积头也是这样。之间的任何图案宽度可以通过使头相对于物质沉积的方向形成角度而实现。另外,如果在与矩形喷嘴尖端相同的方向上取向,则使用矩形雾通道(代替典型使用的圆管或正方形通道)改善沉积图案效果的均匀性。当在与矩形喷嘴尖端的细轴相同的方向上沉积时,需要包覆流以将潜在的尖端堵塞最小化并且聚焦气溶胶雾以产生较小的沉积图案(细线)。
图4显示一个实施方案,其中顶板60和底板61几乎相同,并且雾通道62通过将尖端垫片63夹在两个相同的包覆垫片64、66之间而限定。这样的喷嘴允许将相同的平面型组件用于多种形式的(manifold)雾、气体和废物,而不同的尖端-垫片63层可以用于不同的应用。此尖端-垫片可以通过冲压、机械加工、激光切割、金属丝EDM(wire EDM)、光刻蚀或任何其它制造技术来制造。另外,单一尖端-垫片构造可以由可变性材料如退火不锈钢或高硬度塑料制成,并且具有常见的雾通道宽度,例如1mm宽。在制造加工的过程中,可以设定定位销65之间的距离以得到雾通道62的远端尖端的所需宽度,从而改变沉积线的宽度。另外,假定层之间的密封可以保持,或使用者可以接受适当物质沉积中的短暂中断,则此尖端可以在不用必须改变喷嘴或旋转喷嘴的条件下简单地通过移动定位销65以增加尖端宽度来沉积不同的线宽度。
流动矫直
喷嘴中的层流贡献于不均匀的物质沉积,原因在于流的中心的物质的速度大于在边缘的速度,如图5中所示。因此在图案的中心沉积比边缘更多的物质。当基底相对于喷嘴移动时,产生如图6中所示的不均匀的沉积图案,其中在图案的中心比沿边缘沉积更多的物质。然而,层流优于湍流,因为后者典型地产生较差的聚焦和较差的边缘限定。流动矫直改善层流的沉积均匀性,特别是对于宽图案。流动矫直是流体力学领域中熟知的并且是减少大孔管中湍流并且使得层流曲线更均匀的建立方法,如图7和8中所示。
在一个用于实现层流分布的“矫直”的构造中,宽的矩形雾通道与宽的矩形尖端对齐。如图9中所示,雾通道分隔成多个更小的次通道68。次通道可以为矩形、圆形、正方形或包括任何其它形状。雾通道可以备选地包括任何其它几何结构,例如如图10中所示的交替偏置间隔体70,以实现更均匀的流动图案。与图7和8中所示图案类似,此构造导致沉积密度中的较小波动,原因在于许多小的层流图案彼此靠近地沉积。如图11中所示,这样的波动可以通过下列方法减小:安置与第一排形成偏置的另一排的雾次通道,使得一排中通道的中部正好在下一排相邻通道的壁的上方。图11显示轴向对齐的次通道72。可以通过使一排通道相对于其它通道成角度,从而就在流进入不均匀性聚焦区域中时使各个流交叉而进一步改善局部均匀性。
对于将雾通道再分隔的一个备选方案是使用对直且供给单一宽喷嘴的多个任意形状的相邻雾管或通道。在此实施方案中,优选存在为所有管或通道共有的单一包覆体喷混室。
尽管特别参照这些优选实施方案详细描述了本发明,但是其它实施方案也可以实现相同的结果。本发明的变化和改变对于本领域技术人员是明显的,并且意欲在后附权利要求中涵盖所有这样的改变和等价内容。以上引用的全部参考文献、申请、专利和出版物的整个公开内容都通过引用结合在此。

Claims (17)

1.一种物质沉积组件,所述物质沉积组件包括:
第一盖板和第二盖板,所述盖板中的一个或两个包括用于含物质的气溶胶的入口和一个或多个包覆气体入口;和
在所述盖板之间密封的插入件,所述插入件包括至少一个与所述气溶胶入口和不均匀的喷嘴流体连接的气溶胶通道;
其中所述一个或多个包覆气体入口与包覆体喷混室流体连接,所述包覆体喷混室包封所述至少一个气溶胶通道的出口和所述喷嘴的进口。
2.根据权利要求1所述的沉积组件,其中所述插入件包含两个镜像板,所述镜像板在组装到一起时形成所述气溶胶通道和所述喷嘴。
3.根据权利要求1所述的沉积组件,其中所述包覆气体将所述包覆体喷混室和所述喷嘴中的所述气溶胶包围和聚焦。
4.根据权利要求1所述的沉积组件,其中所述喷嘴为矩形。
5.根据权利要求4所述的沉积组件,其中所述气溶胶通道为矩形,并且与所述矩形喷嘴对齐。
6.根据权利要求1所述的沉积组件,其中所述喷嘴在物质沉积过程中相对于基底是可移动的。
7.根据权利要求6所述的沉积组件,其中所述喷嘴相对于所述喷嘴和所述基底的相对移动方向是可倾斜的。
8.根据权利要求1所述的沉积组件,所述沉积组件还包括连接所述一个或多个包覆气体入口和所述包覆体喷混室的通道,构造所述通道使得所述包覆气体进入所述包覆体喷混室,从而在基本上平行于所述气溶胶在所述气溶胶通道中的流动方向的方向上移动。
9.根据权利要求1所述的沉积组件,其中所述插入件包括尖端垫片,所述尖端垫片包括气溶胶通道。
10.根据权利要求9所述的沉积组件,其中所述尖端垫片是可变形的。
11.根据权利要求10所述的沉积组件,其中所述尖端垫片的变形改变所述气溶胶通道的尖端的宽度。
12.根据权利要求1所述的沉积组件,其中所述至少一个气溶胶通道的至少一部分被再分隔成多个更小的次通道。
13.根据权利要求12所述的沉积组件,其中所述次通道轴向对齐并且排列成两排,第一排中的所述次通道偏移第二排中的所述次通道。
14.根据权利要求13所述的沉积组件,其中所述第一排中的所述次通道相对于所述第二排中的所述次通道形成角度。
15.根据权利要求14所述的沉积组件,其中在相邻次通道中的各个气溶胶流在离开所述气溶胶通道时交叉。
16.根据权利要求1所述的沉积组件,其中所述至少一个气溶胶通道的至少一部分包括交替偏置间隔体。
17.根据权利要求1所述的沉积组件,其中所述包覆体喷混室是不均匀性的。
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