CN101829329A - Tooth antiallergic composition - Google Patents
Tooth antiallergic composition Download PDFInfo
- Publication number
- CN101829329A CN101829329A CN 201010173218 CN201010173218A CN101829329A CN 101829329 A CN101829329 A CN 101829329A CN 201010173218 CN201010173218 CN 201010173218 CN 201010173218 A CN201010173218 A CN 201010173218A CN 101829329 A CN101829329 A CN 101829329A
- Authority
- CN
- China
- Prior art keywords
- component
- preferred
- deionized water
- sodium
- hemodia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 31
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000008367 deionised water Substances 0.000 claims abstract description 25
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 25
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 239000003381 stabilizer Substances 0.000 claims abstract description 11
- 208000024891 symptom Diseases 0.000 claims abstract description 6
- 239000000084 colloidal system Substances 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 21
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 14
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 14
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 claims description 10
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 10
- 235000019264 food flavour enhancer Nutrition 0.000 claims description 9
- 239000005543 nano-size silicon particle Substances 0.000 claims description 7
- 235000010333 potassium nitrate Nutrition 0.000 claims description 7
- 239000004323 potassium nitrate Substances 0.000 claims description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- 229920002125 Sokalan® Polymers 0.000 claims description 6
- 229960001631 carbomer Drugs 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 6
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 6
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 6
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims description 6
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 5
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 5
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 5
- 206010020751 Hypersensitivity Diseases 0.000 claims description 5
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 5
- 239000011698 potassium fluoride Substances 0.000 claims description 5
- 235000003270 potassium fluoride Nutrition 0.000 claims description 5
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 5
- 239000011775 sodium fluoride Substances 0.000 claims description 5
- 235000013024 sodium fluoride Nutrition 0.000 claims description 5
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 5
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 5
- -1 treat hemodia Substances 0.000 claims description 5
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
- SHWNNYZBHZIQQV-UHFFFAOYSA-J EDTA monocalcium diisodium salt Chemical compound [Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O SHWNNYZBHZIQQV-UHFFFAOYSA-J 0.000 claims description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- 208000026935 allergic disease Diseases 0.000 claims description 4
- 230000007815 allergy Effects 0.000 claims description 4
- 229920000609 methyl cellulose Polymers 0.000 claims description 4
- 239000001923 methylcellulose Substances 0.000 claims description 4
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 4
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 4
- 230000007935 neutral effect Effects 0.000 claims description 4
- 229920001983 poloxamer Polymers 0.000 claims description 4
- 229960000502 poloxamer Drugs 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- 230000009467 reduction Effects 0.000 claims description 4
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 229940085605 saccharin sodium Drugs 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 244000246386 Mentha pulegium Species 0.000 claims description 2
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 2
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 2
- 239000004376 Sucralose Substances 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 235000001050 hortel pimenta Nutrition 0.000 claims description 2
- 235000019408 sucralose Nutrition 0.000 claims description 2
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 2
- 230000036541 health Effects 0.000 abstract description 3
- 239000000796 flavoring agent Substances 0.000 abstract description 2
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 235000013355 food flavoring agent Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 description 5
- 210000004268 dentin Anatomy 0.000 description 4
- 239000000606 toothpaste Substances 0.000 description 4
- 229940034610 toothpaste Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- ORILYTVJVMAKLC-UHFFFAOYSA-N adamantane Chemical compound C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 229910001573 adamantine Inorganic materials 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 210000003074 dental pulp Anatomy 0.000 description 1
- 239000000551 dentifrice Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229910052587 fluorapatite Inorganic materials 0.000 description 1
- 229940077441 fluorapatite Drugs 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
Abstract
The invention discloses a tooth antiallergic composition, which belongs to the technical field of oral health care preparation. The composition contains matter which can form a gel or a colloid, matter for curing hemodia, matter for reducing the pain of the hemodia, a pH value regulator, a stabilizing agent, a flavoring agent and deionized water; and the composition has the appearance of the colloid or the gel. The composition is directly coated on the tooth surface or applied to the tooth surface by adopting a denture, and then tooth allergic symptoms and the pain caused by the hemodia are reduced.
Description
Technical field
The invention belongs to oral cavity health preparation field, particularly a kind of tooth antiallergic composition is used to prevent hemodia and alleviates the pain that is caused by allergy.
Background technology
Mainly because working as enamel is destroyed, when dentin exposed, various stimulations changed the dentin flow velocity in dentin surface to hemodia, and this abnormal flow passes to dental pulp, caused the nerve fiber excitement and the generation pain sensation.Hemodia is one of common oral health issue, and it directly influences people's quality of life.Though it is a lot of to resist the development report of irritated toothpaste, the most development all the miscellaneous function of antiallergic as cleaning of teeth, and generally to use one section long time (more than 3 weeks) just can take effect, special-purpose anti-allergic agent is also few.The report of relevant tooth antiallergic has " composition for desensitizing teeth " (Chinese patent CN1077626), " Dentifrice composition and method for desensitizing sensitive teeth " (United States Patent (USP) 4,011,309).
Discover, fluoride by with the dentin effect of tooth, can form the hard fluor-apatite of one deck at dental surface, thereby improve adamantine hardness; Strontium chloride, potassium nitrate can make the permeability of dental tissue significantly reduce, and reduce the sensitivity of gum edge periodontal tissue to various stimulations; Gel or glue compound can mechanicalness be closed the mouth of pipe of matching dential canaliculi, can play anti-allergic effects at short notice.Yet, in the market these several respects are not also had report in conjunction with the product that is used for the hemodia treatment.
Summary of the invention
The object of the invention provides the tooth antiallergic composition of a kind of gel or colloidal.The using method of said composition is for directly being coated onto it dental surface or adopting dens supporter to be applied to dental surface, the pain that can alleviate the hemodia symptom immediately and be caused by allergy.
Compositions of the present invention comprises the material that can form gel or colloidal material, alleviate hemodia, material, pH value regulator, stabilizing agent and the deionized water that reduces hemodia pain; Its mode of appearance is colloid or gel.Concrete component and percentage by weight are as follows:
1) the formed gel of 0.2%-15% or colloidal material, preferred 0.5%-10%, such material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, the polyvinyl alcohol;
2) material of the treatment hemodia of 0.05%-2%, preferred 0.1%-1%, such material is one or more in sodium fluoride, potassium fluoride, the sodium monofluorophosphate;
3) material of the reduction hemodia pain of 0.2%-20%, preferred 0.5-6%, this material is strontium chloride and/or potassium nitrate;
4) the pH value regulator of 0.1%-2%, preferred 0.2%-1%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5) stabilizing agent of 0.01%-2%, preferred 0.1%-1%, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
6) deionized water, surplus are deionized water.
The compound method one of compositions of the present invention: earlier with component 1) be dissolved in the deionized water, then will be except that component 4) other material adding system in dissolve, add component 4 at last) the adjusting pH value, stirring promptly gets tooth antiallergic composition.
The compound method two of compositions of the present invention: earlier with deionized water dissolving except that component 1) other component, add component 1 at last), and promptly got tooth antiallergic composition in 3-15 minute in 3000-10000 rev/min cutter stirring.
Compositions provided by the invention can also be added flavour enhancer.The percentage by weight of each component is behind the interpolation flavour enhancer:
Formed gel 1.0.2%-15% or colloidal material, preferred 0.5%-10%, such material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, the polyvinyl alcohol;
The material of treatment hemodia 2.0.05%-2%, preferred 0.1%-1%, such material is one or more in sodium fluoride, potassium fluoride, the sodium monofluorophosphate;
The material of reduction hemodia pain 3.0.2%-20%, preferred 0.5-6%, this material is strontium chloride and/or potassium nitrate;
4.0.1%-2% pH value regulator, preferred 0.2%-1%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5.0.01%-2% stabilizing agent, preferred 0.1%-1%, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
6.0.02%-2% flavour enhancer, preferred 0.1%-1% is used to regulate the compositions mouthfeel, and flavour enhancer is one or more in water solublity Herba Menthae brain, peppermint essence, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
7. deionized water, surplus is a deionized water.
Add the compound method one of the compositions of flavour enhancer: earlier component 1 is dissolved in the deionized water, will dissolves in other material adding system except that component 4 then, add component 4 at last and regulate pH value, stirring promptly gets tooth antiallergic composition.
Add the compound method two of the compositions of flavour enhancer: earlier with deionized water dissolving other component except that component 1, add component 1 at last, and promptly got tooth antiallergic composition in 3-15 minute in 3000-10000 rev/min cutter stirring.
Compared with prior art, the tooth antiallergic composition provided by the invention pain that can alleviate the hemodia symptom immediately and cause by allergy.Institute's test patient is with back 10 seconds, effective percentage can reach 80% and more than.
The specific embodiment
Following non-limiting example is further narrated the preferred embodiment in the scope of the invention.In the case without departing from the scope of the present invention, a lot of variations of present embodiment are possible.
Embodiment 1
Weight percentages of components (%)
Carbomer 4.00
Sodium fluoride 0.24
Potassium nitrate 6.00
Sodium hydroxide 0.20
HEDP 0.50
Aspartame 0.10
Fructus Citri tangerinae flavor essence 0.15
Deionized water 88.81
Preparation method: earlier carbomer is dissolved in the deionized water, will dissolves in other material adding system except that sodium hydroxide then, add sodium hydroxide at last and stir and promptly get tooth antiallergic composition.The said composition of preparation is a gel form.
Embodiment 2
Weight percentages of components (%)
Nano silicon 5.00
Sodium monofluorophosphate 0.45
Potassium nitrate 5.00
Triethanolamine 0.45
Tetrasodium pyrophosphate 0.22
Saccharin sodium 0.05
Fructus Citri Limoniae essence 0.15
Deionized water 88.68
Preparation method:, add nano silicon then and promptly got tooth antiallergic composition in 5 minutes in 6000 rev/mins cutter stirring earlier with deionized water dissolving other component except that nano silicon.The said composition of preparation is a gel form.
Embodiment 3
Weight percentages of components (%)
Carboxymethyl cellulose 7.00
Potassium fluoride 0.30
Strontium chloride 2.50
Sodium carbonate 0.45
EDTA disodium 0.30
Stevioside 0.05
Fructus Citri Limoniae essence 0.15
Deionized water 89.25
Preparation method: earlier carboxymethyl cellulose is dissolved in the deionized water, will dissolves in other material adding system except that sodium carbonate then, add sodium carbonate at last and stir and promptly get tooth antiallergic composition.The said composition of preparation is the colloid form.
60 easy patients hypersensitive of tooth are divided into four groups, the antiallergic toothpaste of three kinds of tooth antiallergic compositions among the embodiment 1-3 and the conventional use of elimination hemodia symptom is at present tested.Each organizes the patient after accepting various stimulations, uses above-mentioned three kinds of compositionss and toothpaste respectively, observes each patient and uses afterreaction.By test result as can be known, compositions of the present invention can be eliminated the hemodia symptom fast, and uses toothpaste to need just can take effect more than 3 weeks.
| 10 seconds effective percentage | The 10min effective percentage | |
| Embodiment 1 | ??87％ | ??100％ |
| Embodiment 2 | ??87％ | ??93％ |
| Embodiment 3 | ??80％ | ??100％ |
Claims (9)
1. a tooth antiallergic composition is characterized in that, described compositions comprises the material that can form gel or colloidal material, treat hemodia, material, pH value regulator, stabilizing agent and the deionized water that reduces hemodia pain; Its mode of appearance is colloid or gel.
2. a kind of tooth antiallergic composition according to claim 1 is characterized in that, the concrete component and the percentage by weight of described compositions are as follows:
1) the formed gel of 0.2%-15% or colloidal material, preferred 0.5%-10%, such material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, the polyvinyl alcohol;
2) material of the treatment hemodia of 0.05%-2%, preferred 0.1%-1%, such material is one or more in sodium fluoride, potassium fluoride, the sodium monofluorophosphate;
3) material of the reduction hemodia pain of 0.2%-20%, preferred 0.5-6%, this material is strontium chloride and/or potassium nitrate;
4) the pH value regulator of 0.1%-2%, preferred 0.2%-1%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5) stabilizing agent of 0.01%-2%, preferred 0.1%-1%, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
6) deionized water, surplus are deionized water.
3. prepare the method for the described a kind of tooth antiallergic composition of claim 2, it is characterized in that, its concrete preparation steps is: earlier with the component in the claim 2 1) be dissolved in the deionized water, then will be except that component 4) other material adding system in dissolve, add component 4 at last) regulate pH value, stirring promptly gets tooth antiallergic composition.
4. prepare the method for the described a kind of tooth antiallergic composition of claim 2, it is characterized in that, its concrete preparation steps is: other component first using in the deionized water dissolving claim 2 except that component 1), add component 1 at last), and stir in 3000-10000 rev/min cutter and promptly to get tooth antiallergic composition in 3-15 minute.
5. a kind of tooth antiallergic composition according to claim 1 is characterized in that described compositions also contains flavour enhancer.
6. a kind of tooth antiallergic composition according to claim 5 is characterized in that, the concrete component and the percentage by weight of described compositions are as follows:
1) the formed gel of 0.2%-15% or colloidal material, preferred 0.5%-10%, such material is one or more in polyvinylpyrrolidone, poloxamer, nano silicon, carbomer, methylcellulose, carboxymethyl cellulose, the polyvinyl alcohol;
2) material of the treatment hemodia of 0.05%-2%, preferred 0.1%-1%, such material is one or more in sodium fluoride, potassium fluoride, the sodium monofluorophosphate;
3) material of the reduction hemodia pain of 0.2%-20%, preferred 0.5-6%, this material is strontium chloride and/or potassium nitrate;
4) the pH value regulator of 0.1%-2%, preferred 0.2%-1%, the pH value that is used to regulate composition system is near neutral, and the pH value regulator is one or more in sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, the triethanolamine;
5) stabilizing agent of 0.01%-2%, preferred 0.1%-1%, stabilizing agent is one or more in tetrasodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDTA disodium, EDTA calcium disodium, the HEDP;
6) flavour enhancer of 0.02%-2%, preferred 0.1%-1% is used to regulate the compositions mouthfeel, and flavour enhancer is one or more in water solublity Herba Menthae brain, peppermint essence, fruity essence, saccharin sodium, aspartame, sucralose, the stevioside;
7) deionized water, surplus are deionized water.
7. prepare the method for the described a kind of tooth antiallergic composition of claim 6, it is characterized in that, its concrete preparation steps is: earlier with the component in the claim 6 1) be dissolved in the deionized water, then will be except that component 4) other material adding system in dissolve, add component 4 at last) regulate pH value, stirring promptly gets tooth antiallergic composition.
8. prepare the method for the described a kind of tooth antiallergic composition of claim 6, it is characterized in that, its concrete preparation steps is: other component first using in the deionized water dissolving claim 6 except that component 1), add component 1 at last), and stir in 3000-10000 rev/min cutter and promptly to get tooth antiallergic composition in 3-15 minute.
9. according to claim 1,2,5 or 6 described a kind of tooth antiallergic compositions, it is characterized in that, the using method of described compositions is for directly being coated onto it dental surface or adopting dens supporter to be applied to dental surface, the pain that alleviates the hemodia symptom immediately and caused by allergy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101732189A CN101829329B (en) | 2010-05-11 | 2010-05-11 | Tooth antiallergic composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101732189A CN101829329B (en) | 2010-05-11 | 2010-05-11 | Tooth antiallergic composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101829329A true CN101829329A (en) | 2010-09-15 |
| CN101829329B CN101829329B (en) | 2012-06-20 |
Family
ID=42713646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101732189A Expired - Fee Related CN101829329B (en) | 2010-05-11 | 2010-05-11 | Tooth antiallergic composition |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101829329B (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416002A (en) * | 2011-11-23 | 2012-04-18 | 南京泽恒医药技术开发有限公司 | Composition for precursor gel type fluoride chewing tablet |
| CN102670457A (en) * | 2012-06-06 | 2012-09-19 | 广州中汉口腔用品有限公司 | Tooth powder and fabrication process thereof |
| CN106109493A (en) * | 2016-08-05 | 2016-11-16 | 四川北极光口腔医疗器械有限公司 | One is exclusively used in hypo-allergenic combination medicament during planting tooth |
| CN106138090A (en) * | 2016-08-05 | 2016-11-23 | 四川北极光口腔医疗器械有限公司 | The preparation method of hypo-allergenic combination medicament during one tooth-implanting |
| CN106344432A (en) * | 2016-11-07 | 2017-01-25 | 长沙蒽俏蔓生物科技有限公司 | Tooth whitening gel and preparation method and application thereof |
| CN106880506A (en) * | 2017-03-16 | 2017-06-23 | 成都泗翰科技有限公司 | Oral care product that a kind of antiallergic cleans the teeth and preparation method thereof |
| CN109453193A (en) * | 2018-09-01 | 2019-03-12 | 济南秦鲁药业科技有限公司 | A kind of desensitizing dental gel and preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286623A (en) * | 1998-03-06 | 2001-03-07 | G·加利和G·帕奇尼意大利医药有限公司 | Desensitizing dental composition |
-
2010
- 2010-05-11 CN CN2010101732189A patent/CN101829329B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286623A (en) * | 1998-03-06 | 2001-03-07 | G·加利和G·帕奇尼意大利医药有限公司 | Desensitizing dental composition |
Non-Patent Citations (1)
| Title |
|---|
| 《流程药剂学》 20030930 龙晓英 《外用凝胶剂》 第105页 3,4,7,8 , 1 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102416002A (en) * | 2011-11-23 | 2012-04-18 | 南京泽恒医药技术开发有限公司 | Composition for precursor gel type fluoride chewing tablet |
| CN102670457A (en) * | 2012-06-06 | 2012-09-19 | 广州中汉口腔用品有限公司 | Tooth powder and fabrication process thereof |
| CN106109493A (en) * | 2016-08-05 | 2016-11-16 | 四川北极光口腔医疗器械有限公司 | One is exclusively used in hypo-allergenic combination medicament during planting tooth |
| CN106138090A (en) * | 2016-08-05 | 2016-11-23 | 四川北极光口腔医疗器械有限公司 | The preparation method of hypo-allergenic combination medicament during one tooth-implanting |
| CN106344432A (en) * | 2016-11-07 | 2017-01-25 | 长沙蒽俏蔓生物科技有限公司 | Tooth whitening gel and preparation method and application thereof |
| CN106880506A (en) * | 2017-03-16 | 2017-06-23 | 成都泗翰科技有限公司 | Oral care product that a kind of antiallergic cleans the teeth and preparation method thereof |
| CN109453193A (en) * | 2018-09-01 | 2019-03-12 | 济南秦鲁药业科技有限公司 | A kind of desensitizing dental gel and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101829329B (en) | 2012-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101829329B (en) | Tooth antiallergic composition | |
| JP5684454B2 (en) | Oral care therapeutic and prophylactic compositions | |
| RU2412689C2 (en) | High-fluoride oral care composition and method for maintaining anti-caries activity | |
| JPH08504816A (en) | Oral composition containing antiplaque and anticalculus agent | |
| CN106236649B (en) | Folium artemisiae argyi toothpaste | |
| RU2017130866A (en) | COMPOSITIONS FOR CARE OF THE ORAL CAVITY AND METHODS OF USE | |
| RU2604667C2 (en) | Oral care compositions | |
| WO2014031035A1 (en) | Mineral-enzyme complex for fortifying and whitening tooth enamel, oral hygiene composition and toothpaste | |
| CN103006455A (en) | Method for preparing chitosan tooth-protection toothpaste | |
| KR20160124009A (en) | Oral composition | |
| CN104983744A (en) | Oral care composition containing periplaneta americana, oral care products and preparation methods of oral care composition and oral care products | |
| TWI542362B (en) | Color changing compositions | |
| JP2007197393A (en) | Dentifrice | |
| CN110755337A (en) | Anti-allergy repairing toothpaste | |
| CN101829032B (en) | Dual-purpose toothpaste composition and preparation method thereof | |
| CN102512336B (en) | Desensitizing toothpaste and desensitizing day-and-night combined toothpaste | |
| KR20170037230A (en) | Oral composition comprising cassava extract | |
| KR100308247B1 (en) | Compositions for cleaning oral cavity | |
| JP6756553B2 (en) | Gel toothpaste | |
| CN106109493A (en) | One is exclusively used in hypo-allergenic combination medicament during planting tooth | |
| CN106138090A (en) | The preparation method of hypo-allergenic combination medicament during one tooth-implanting | |
| KR102030106B1 (en) | Oral composition masking salty taste | |
| KR102550067B1 (en) | Oral Composition having policresulen and fluorine compound | |
| KR102337307B1 (en) | Low irritating oral composition | |
| RU2457824C2 (en) | Therapeutic and prophylactic toothpaste "stomatol" |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Shaojun Document name: the First Notification of an Office Action |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| DD01 | Delivery of document by public notice | ||
| DD01 | Delivery of document by public notice |
Addressee: Li Shaojun Document name: Notification to Pay the Fees |
|
| DD01 | Delivery of document by public notice |
Addressee: Li Shaojun Document name: Notification of eligibility |
|
| DD01 | Delivery of document by public notice | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210712 Address after: 276113 Miaoshan Town, Tancheng County, Linyi City, Shandong Province Patentee after: Tancheng Mazhan orthopedic Hospital Address before: 100083 Xipin Technology (Beijing) Co.,Ltd., Building 528, Building D, No. 2 Shangdi Information Road, Haidian District, Beijing Patentee before: Li Shaojun |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120620 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |