CN106138090A - The preparation method of hypo-allergenic combination medicament during one tooth-implanting - Google Patents
The preparation method of hypo-allergenic combination medicament during one tooth-implanting Download PDFInfo
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- CN106138090A CN106138090A CN201610637772.5A CN201610637772A CN106138090A CN 106138090 A CN106138090 A CN 106138090A CN 201610637772 A CN201610637772 A CN 201610637772A CN 106138090 A CN106138090 A CN 106138090A
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- tooth
- sodium
- hypo
- combination medicament
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0063—Periodont
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- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses the preparation method belonging to hypo-allergenic combination medicament during a tooth-implanting of oral health preparation technical field.This combination medicament comprises the material treating hemodia, the material reducing dentinal sensitivity pain, pH value regulator, stabilizer, flavoring agent and deionized water；This combination medicament is directly applied to dental surface or uses denture fixing device to be applied to dental surface, hemodia symptom and the pain being caused by allergy can be mitigated immediately.
Description
Technical field
The invention belongs to oral health preparation field, particularly to the system of hypo-allergenic combination medicament during a tooth-implanting
Preparation Method, for preventing hemodia and mitigating the pain being caused by allergy.
Background technology
Hemodia is primarily due to when enamel is destroyed, and when dentine exposes, various spread effects are in dentine table
Face, makes dentine flow velocity change, and this abnormal flow passes to dental pulp, causes nerve fibre excited and produces the pain sensation.Tooth
Tooth allergy is one of most common oral health issue, and it directly affects the quality of life of people.Although grinding of antagonism allergy toothpaste
System report is a lot, but most develop all antiallergy as the miscellaneous function of cleaning of teeth, and typically to use one section very long
Time (more than 3 weeks) just can take effect, special anti-allergic agent is simultaneously few, research discovery, fluoride by with the tooth of tooth this
Matter effect, can form one layer of hard fluor-apatite at dental surface, thus improve adamantine hardness；Strontium chloride, nitric acid
Potassium can make the permeability of dental tissue significantly reduce, and reduces the sensitiveness to various stimulations for the gum edge periodontium；Gel or colloid
Compound mechanicalness can close the mouth of pipe matching dential canaliculi, can play anti-allergic effects at short notice.But, in the market
The product that the combination of this several respects is used for dental sensitivity treatment is not also had been reported that.
Content of the invention
Instant invention overcomes the deficiencies in the prior art, the preparation side of hypo-allergenic combination medicament during a tooth-implanting is provided
Method, the using method of said composition is for being directly applied to the dental surface after planting tooth or using denture fixing device to be applied to dental surface, i.e.
Hemodia symptom and the pain being caused by allergy can be mitigated immediately.
For solving above-mentioned technical problem, the present invention by the following technical solutions:
The preparation method of hypo-allergenic combination medicament during one tooth-implanting, described step is as follows:
(1) material of the treatment hemodia that percentage by weight is 3%-5% being added percentage by weight is 90.8%-95.8%
Deionized water in, and in 3000-10000 rev/min cutter stirring 1-2 minute;Being subsequently adding percentage by weight is
0.1%-0.2% reduction dentinal sensitivity pain material, and in 3000-10000 rev/min cutter stirring 1-2 divide
Clock;Then the pH value regulator that percentage by weight is 1%-2% stabilizer and percentage by weight is 0.1%-2% is added,
I.e. can get hypo-allergenic combination medicament after the cutter stirring 8-12 minute of 3000-10000 rev/min;Described treatment tooth
The material of allergy is sodium fluoride, potassium fluoride, one or more in sodium monofluorophosphate；The thing of described reduction dentinal sensitivity pain
Matter is strontium chloride and/or potassium nitrate；Described pH value regulator is NaOH, potassium hydroxide, sodium carbonate, sodium acid carbonate, three second
One or more in hydramine；Described stabilizer be sodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDETATE SODIUM, EDETATE SODIUM calcium,
One or more in 1-hydroxy ethylidene-1,1-diphosphonic acid.
Further, the material of described treatment hemodia is sodium fluoride.
Further, the material of described reduction dentinal sensitivity pain is strontium chloride.
Further, described pH value regulator is NaOH.
Further, described stabilizer is sodium pyrophosphate.
Compared with prior art, the invention has the beneficial effects as follows: the tooth antiallergic composition that the present invention provides can stand
I.e. mitigate hemodia symptom and the pain being caused by allergy.Tested patient, with latter 10 seconds, efficient can reach 80%
More than and.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further illustrated.Embodiments of the present invention are including but not limited to following
Embodiment.
Following non-limiting example is further discussed below the preferred embodiment in the scope of the invention.Without departing substantially from the present invention
In the case of scope, a lot of changes of the present embodiment are possible.
Embodiment 1
Weight percentages of components (%)
Sodium fluoride 5%
Strontium chloride 0.2%
NaOH 2%
Sodium pyrophosphate 2%
Deionized water 90.8%
Preparation method: in the deionized water add percentage by weight to be 90.8% sodium fluoride that percentage by weight is 5%, and
In the cutter stirring 1-2 minute of 3000-10000 rev/min;It is subsequently adding the strontium chloride that percentage by weight is 0.2%, and
In the cutter stirring 1-2 minute of 3000-10000 rev/min;Then adding percentage by weight is 2% sodium pyrophosphate and weight
Amount percentage is the NaOH of 2%, and the cutter stirring 8-12 minute after 3000-10000 rev/min i.e. can be prevented
Allergy combination medicament.
Embodiment 2
Weight percentages of components (%)
Sodium fluoride 3%
Strontium chloride 0.1%
NaOH 0.1%
Sodium pyrophosphate 1%
Deionized water 95.8%
Preparation method: in the deionized water add percentage by weight to be 95.8% sodium fluoride that percentage by weight is 3%, and
In the cutter stirring 1-2 minute of 3000-10000 rev/min;It is subsequently adding the strontium chloride that percentage by weight is 0.1%, and
In the cutter stirring 1-2 minute of 3000-10000 rev/min;Then adding percentage by weight is 1% sodium pyrophosphate and weight
Amount percentage is the NaOH of 0.1%, i.e. available after the cutter stirring 8-12 minute of 3000-10000 rev/min
Hypo-allergenic combination medicament.
Embodiment 2
Weight percentages of components (%)
Sodium fluoride 4%
Strontium chloride 0.15%
NaOH 1%
Sodium pyrophosphate 1.5%
Deionized water 93.35%
Preparation method: in the deionized water add percentage by weight to be 93.35% sodium fluoride that percentage by weight is 4%, and
In the cutter stirring 1-2 minute of 3000-10000 rev/min;It is subsequently adding the strontium chloride that percentage by weight is 0.15%, and
In the cutter stirring 1-2 minute of 3000-10000 rev/min;Then add percentage by weight be 1.5% sodium pyrophosphate and
Percentage by weight is the NaOH of 1%, i.e. available after the cutter stirring 8-12 minute of 3000-10000 rev/min
Hypo-allergenic combination medicament.
The patient of easy for 60 teeth allergy is divided into four groups, to three kinds of tooth antiallergics combinations in embodiment 1-3
Thing and at present elimination hemodia symptom conventional use of antiallergy toothpaste are tested.Each group patient is accepting various stimulation
After, use above-mentioned three kinds of compositions and toothpaste respectively, observe each patient and use rear reaction.From test result, the group of the present invention
Compound can quickly eliminate hemodia symptom, and uses toothpaste to need just can take effect for more than 3 weeks.
It is embodiments of the invention as mentioned above.The present invention is not limited to above-mentioned embodiment, and anyone should learn
The structure change made under the enlightenment of the present invention, every have same or like technical scheme with the present invention, each falls within this
Within the protection domain of invention.
Claims (5)
1. the preparation method of hypo-allergenic combination medicament during a tooth-implanting, it is characterised in that: described step is as follows:
(1) material of the treatment hemodia that percentage by weight is 3%-5% being added percentage by weight is 90.8%-95.8%
Deionized water in, and in 3000-10000 rev/min cutter stirring 1-2 minute;Being subsequently adding percentage by weight is
0.1%-0.2% reduction dentinal sensitivity pain material, and in 3000-10000 rev/min cutter stirring 1-2 divide
Clock;Then the pH value regulator that percentage by weight is 1%-2% stabilizer and percentage by weight is 0.1%-2% is added,
I.e. can get hypo-allergenic combination medicament after the cutter stirring 8-12 minute of 3000-10000 rev/min;Described treatment tooth
The material of allergy is sodium fluoride, potassium fluoride, one or more in sodium monofluorophosphate；The thing of described reduction dentinal sensitivity pain
Matter is strontium chloride and/or potassium nitrate；Described pH value regulator is NaOH, potassium hydroxide, sodium carbonate, sodium acid carbonate, three second
One or more in hydramine；Described stabilizer be sodium pyrophosphate, sodium dihydrogen phosphate, EDTA, EDETATE SODIUM, EDETATE SODIUM calcium,
One or more in 1-hydroxy ethylidene-1,1-diphosphonic acid.
2. the preparation method of hypo-allergenic combination medicament during a tooth-implanting according to claim 1, it is characterised in that: institute
The material stating treatment hemodia is sodium fluoride.
3. the preparation method of hypo-allergenic combination medicament during a tooth-implanting according to claim 1, it is characterised in that: institute
The material stating reduction dentinal sensitivity pain is strontium chloride.
4. the preparation method of hypo-allergenic combination medicament during a tooth-implanting according to claim 1, it is characterised in that: institute
The pH value regulator stated is NaOH.
5. the preparation method of hypo-allergenic combination medicament during a tooth-implanting according to claim 1, it is characterised in that: institute
Stating stabilizer is sodium pyrophosphate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610637772.5A CN106138090A (en) | 2016-08-05 | 2016-08-05 | The preparation method of hypo-allergenic combination medicament during one tooth-implanting |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610637772.5A CN106138090A (en) | 2016-08-05 | 2016-08-05 | The preparation method of hypo-allergenic combination medicament during one tooth-implanting |
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| CN106138090A true CN106138090A (en) | 2016-11-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610637772.5A Pending CN106138090A (en) | 2016-08-05 | 2016-08-05 | The preparation method of hypo-allergenic combination medicament during one tooth-implanting |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688281A (en) * | 2002-08-05 | 2005-10-26 | 高露洁-棕榄公司 | Dentinal desensitizing toothpaste |
| CN101507689A (en) * | 2009-04-02 | 2009-08-19 | 南昌普洋科技有限公司 | Gel for bleaching and whitening teeth |
| CN101829329A (en) * | 2010-05-11 | 2010-09-15 | 李少君 | Tooth antiallergic composition |
-
2016
- 2016-08-05 CN CN201610637772.5A patent/CN106138090A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688281A (en) * | 2002-08-05 | 2005-10-26 | 高露洁-棕榄公司 | Dentinal desensitizing toothpaste |
| CN101507689A (en) * | 2009-04-02 | 2009-08-19 | 南昌普洋科技有限公司 | Gel for bleaching and whitening teeth |
| CN101829329A (en) * | 2010-05-11 | 2010-09-15 | 李少君 | Tooth antiallergic composition |
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Application publication date: 20161123 |
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