CN101824446A - 反向沉淀生产硫酸软骨素的方法 - Google Patents
反向沉淀生产硫酸软骨素的方法 Download PDFInfo
- Publication number
- CN101824446A CN101824446A CN 201010112838 CN201010112838A CN101824446A CN 101824446 A CN101824446 A CN 101824446A CN 201010112838 CN201010112838 CN 201010112838 CN 201010112838 A CN201010112838 A CN 201010112838A CN 101824446 A CN101824446 A CN 101824446A
- Authority
- CN
- China
- Prior art keywords
- chondroitin sulfate
- precipitation
- alcohol
- weight concentration
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title claims abstract description 44
- 229920001287 Chondroitin sulfate Polymers 0.000 title claims abstract description 44
- 229940059329 chondroitin sulfate Drugs 0.000 title claims abstract description 44
- 238000001556 precipitation Methods 0.000 title claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 25
- 230000003647 oxidation Effects 0.000 claims abstract description 9
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 9
- 239000000047 product Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 10
- 229920002678 cellulose Polymers 0.000 claims description 10
- 239000001913 cellulose Substances 0.000 claims description 10
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000010792 warming Methods 0.000 claims description 8
- 239000003513 alkali Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 210000000845 cartilage Anatomy 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000011780 sodium chloride Substances 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 230000003068 static effect Effects 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- 239000011593 sulfur Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 239000012286 potassium permanganate Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 9
- 239000003960 organic solvent Substances 0.000 abstract description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 241000251730 Chondrichthyes Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- AEMOLEFTQBMNLQ-QIUUJYRFSA-N beta-D-glucuronic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000000600 disaccharide group Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Abstract
Description
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010112838 CN101824446B (zh) | 2010-02-24 | 2010-02-24 | 反向沉淀生产硫酸软骨素的方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010112838 CN101824446B (zh) | 2010-02-24 | 2010-02-24 | 反向沉淀生产硫酸软骨素的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101824446A true CN101824446A (zh) | 2010-09-08 |
| CN101824446B CN101824446B (zh) | 2012-12-12 |
Family
ID=42688609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010112838 Active CN101824446B (zh) | 2010-02-24 | 2010-02-24 | 反向沉淀生产硫酸软骨素的方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101824446B (zh) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102134288A (zh) * | 2011-04-19 | 2011-07-27 | 南京工业大学 | 一种猪硫酸软骨素的提取工艺 |
| CN102190740A (zh) * | 2011-04-08 | 2011-09-21 | 淮安麦德森制药有限公司 | 硫酸软骨素的制备方法 |
| CN102199229A (zh) * | 2011-04-08 | 2011-09-28 | 淮安麦德森制药有限公司 | 一种硫酸软骨素的制备方法 |
| CN102850466A (zh) * | 2011-06-28 | 2013-01-02 | 西藏金稞集团有限责任公司 | 牦牛骨制取硫酸软骨素的一种方法 |
| CN103665186A (zh) * | 2013-10-21 | 2014-03-26 | 青岛九龙生物医药有限公司 | 一种提高硫酸软骨素钠含量的方法 |
| CN103804518A (zh) * | 2013-11-25 | 2014-05-21 | 青岛九龙生物医药有限公司 | 提高硫酸软骨素含量的制备方法 |
| CN104177512A (zh) * | 2014-08-26 | 2014-12-03 | 淮安麦德森制药有限公司 | 催化法生产低分子硫酸软骨素的方法 |
| CN104448040A (zh) * | 2014-12-24 | 2015-03-25 | 青岛九龙生物医药有限公司 | 硫酸软骨素的制备方法 |
| CN106749765A (zh) * | 2017-02-09 | 2017-05-31 | 高焕顺 | 一种制备高酶解液相含量的方法 |
| CN106832055A (zh) * | 2017-02-27 | 2017-06-13 | 日照岚山生化制品有限公司 | 一种控制硫酸软骨素钠密度的生产工艺 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1447820A (zh) * | 2000-07-21 | 2003-10-08 | 阿文蒂斯药物股份有限公司 | 由肝素衍生的多糖混合物、其制备方法及其药物组合物 |
| CN1884307A (zh) * | 2006-06-01 | 2006-12-27 | 扬州日兴生物化工制品有限公司 | 脱乙酰硫酸软骨素制备技术 |
-
2010
- 2010-02-24 CN CN 201010112838 patent/CN101824446B/zh active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1447820A (zh) * | 2000-07-21 | 2003-10-08 | 阿文蒂斯药物股份有限公司 | 由肝素衍生的多糖混合物、其制备方法及其药物组合物 |
| CN1884307A (zh) * | 2006-06-01 | 2006-12-27 | 扬州日兴生物化工制品有限公司 | 脱乙酰硫酸软骨素制备技术 |
Non-Patent Citations (2)
| Title |
|---|
| 《Am Acad Orth Surg》 19911231 Thomas N W Proteoglycans:Structure and Function 119-122 全文 第18卷, 第1期 * |
| 《中国医院药学杂质》 19990928 汪建生等 肝素钠精制工艺研究 528-529 1-3 第19卷, 第9期 * |
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102190740A (zh) * | 2011-04-08 | 2011-09-21 | 淮安麦德森制药有限公司 | 硫酸软骨素的制备方法 |
| CN102199229A (zh) * | 2011-04-08 | 2011-09-28 | 淮安麦德森制药有限公司 | 一种硫酸软骨素的制备方法 |
| CN102190740B (zh) * | 2011-04-08 | 2012-10-24 | 淮安麦德森制药有限公司 | 硫酸软骨素的制备方法 |
| CN102134288B (zh) * | 2011-04-19 | 2012-07-25 | 南京工业大学 | 一种猪硫酸软骨素的提取工艺 |
| CN102134288A (zh) * | 2011-04-19 | 2011-07-27 | 南京工业大学 | 一种猪硫酸软骨素的提取工艺 |
| CN102850466B (zh) * | 2011-06-28 | 2016-08-17 | 西藏金稞集团有限责任公司 | 牦牛骨制取硫酸软骨素的一种方法 |
| CN102850466A (zh) * | 2011-06-28 | 2013-01-02 | 西藏金稞集团有限责任公司 | 牦牛骨制取硫酸软骨素的一种方法 |
| CN103665186A (zh) * | 2013-10-21 | 2014-03-26 | 青岛九龙生物医药有限公司 | 一种提高硫酸软骨素钠含量的方法 |
| CN103804518A (zh) * | 2013-11-25 | 2014-05-21 | 青岛九龙生物医药有限公司 | 提高硫酸软骨素含量的制备方法 |
| CN104177512A (zh) * | 2014-08-26 | 2014-12-03 | 淮安麦德森制药有限公司 | 催化法生产低分子硫酸软骨素的方法 |
| CN104448040A (zh) * | 2014-12-24 | 2015-03-25 | 青岛九龙生物医药有限公司 | 硫酸软骨素的制备方法 |
| CN106749765A (zh) * | 2017-02-09 | 2017-05-31 | 高焕顺 | 一种制备高酶解液相含量的方法 |
| CN106832055A (zh) * | 2017-02-27 | 2017-06-13 | 日照岚山生化制品有限公司 | 一种控制硫酸软骨素钠密度的生产工艺 |
| CN106832055B (zh) * | 2017-02-27 | 2019-06-28 | 日照岚山生化制品有限公司 | 一种控制硫酸软骨素钠密度的生产工艺 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101824446B (zh) | 2012-12-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101824446B (zh) | 反向沉淀生产硫酸软骨素的方法 | |
| CN101983973B (zh) | 一种卡拉胶的提取与加工工艺 | |
| CN104963228A (zh) | 利用葵花籽壳制备纳米纤维素的方法 | |
| CN104558238B (zh) | 一种提取海藻酸钠的工艺 | |
| CN103643577A (zh) | 一种利用蒜皮制备纳米纤维素晶须的方法 | |
| CN103060288B (zh) | 一种从猪睾丸中提取玻璃酸酶的方法 | |
| CN105601755A (zh) | 一种纤维素黄原酸盐重金属捕集剂的制备方法及使用方法 | |
| CN102190740B (zh) | 硫酸软骨素的制备方法 | |
| CN104480228A (zh) | 一种利用虾蟹壳制取氨糖的方法 | |
| CN103204823B (zh) | 一种1,2-苯并异噻唑-3-酮的提纯方法 | |
| CN100560653C (zh) | 一种利用酶解法提取水溶性红曲色素的方法 | |
| CN103483403B (zh) | 一种从橘渣中提纯橙皮甙的循环提取方法 | |
| CN103113488B (zh) | 一种易分散及溶解的低酰基透明型结冷胶的提取方法 | |
| CN110330439A (zh) | 一种不引入杂质离子的甘氨酸锌络合物及其制备方法 | |
| CN103804518A (zh) | 提高硫酸软骨素含量的制备方法 | |
| CN101979399A (zh) | 甾体激素地塞米松重要中间体甲基四烯物的生产方法 | |
| CN104448040A (zh) | 硫酸软骨素的制备方法 | |
| CN105001353A (zh) | 一种粗品肝素钠精制优化工艺 | |
| CN102443070A (zh) | 一种氧化淀粉的制备方法 | |
| CN103087201A (zh) | 运用半水媒法制高粘工业级羧甲基纤维素生产工艺 | |
| CN104497169A (zh) | 乳化法制备硫酸软骨素 | |
| CN103641935B (zh) | 硫酸软骨素的提取方法 | |
| CN111518227B (zh) | 一种琼脂胶液的制备方法 | |
| CN106381744A (zh) | 一种从芦苇中分离纳米纤维素的方法 | |
| CN102199229A (zh) | 一种硫酸软骨素的制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: HUAI'AN MAIDESEN PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: HUAIAN MDC CHEMICAL CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 223005 No. 58 North Hefei Road, Huaian economic and Technological Development Zone, Jiangsu Patentee after: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Address before: 223001 No. 58 Hefei North Road, Huaian Economic Development Zone, Jiangsu Patentee before: HUAIAN MDC CHEMICAL Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for producing chondroitin sulfate by reverse precipitation Effective date of registration: 20170927 Granted publication date: 20121212 Pledgee: Huaian Qinghe private economy Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: 2017320000035 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PM01 | Change of the registration of the contract for pledge of patent right |
Change date: 20180906 Registration number: 2017320000035 Pledgee after: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgee before: Huaian Qinghe private economy Company limited by guarantee |
|
| PM01 | Change of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20180911 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: 2017320000035 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for producing chondroitin sulfate by reverse precipitation Effective date of registration: 20180914 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: 2018320000181 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20190911 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: 2018320000181 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for producing chondroitin sulfate by reverse precipitation Effective date of registration: 20190912 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2019320000130 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200817 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2019320000130 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Production of chondroitin sulfate by reverse precipitation Effective date of registration: 20200819 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2020320000186 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20210830 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2020320000186 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method for producing chondroitin sulfate by reverse precipitation Effective date of registration: 20210831 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021320000201 |
|
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 223005 No. 58, Hefei North Road, Huai'an Economic and Technological Development Zone, Jiangsu Province Patentee after: Jiangsu Madsen Pharmaceutical Co.,Ltd. Address before: 223005 No. 58, Hefei North Road, Huai'an Economic and Technological Development Zone, Jiangsu Province Patentee before: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20211226 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021320000201 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Method of producing chondroitin sulfate by reverse precipitation Effective date of registration: 20230206 Granted publication date: 20121212 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: Jiangsu Madsen Pharmaceutical Co.,Ltd. Registration number: Y2023320000059 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |