CN102190740B - 硫酸软骨素的制备方法 - Google Patents
硫酸软骨素的制备方法 Download PDFInfo
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- CN102190740B CN102190740B CN201110087027A CN201110087027A CN102190740B CN 102190740 B CN102190740 B CN 102190740B CN 201110087027 A CN201110087027 A CN 201110087027A CN 201110087027 A CN201110087027 A CN 201110087027A CN 102190740 B CN102190740 B CN 102190740B
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- chondroitin sulfate
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- 229920001287 Chondroitin sulfate Polymers 0.000 title claims abstract description 30
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 229940059329 chondroitin sulfate Drugs 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 24
- 238000001556 precipitation Methods 0.000 claims abstract description 20
- 239000000047 product Substances 0.000 claims abstract description 16
- 239000002244 precipitate Substances 0.000 claims abstract description 14
- 230000018044 dehydration Effects 0.000 claims abstract description 13
- 238000006297 dehydration reaction Methods 0.000 claims abstract description 13
- 239000011780 sodium chloride Substances 0.000 claims abstract description 12
- 210000000845 cartilage Anatomy 0.000 claims abstract description 10
- 238000001035 drying Methods 0.000 claims abstract description 9
- 239000000706 filtrate Substances 0.000 claims abstract description 9
- 239000003513 alkali Substances 0.000 claims abstract description 8
- 238000009835 boiling Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 230000008021 deposition Effects 0.000 claims description 25
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 claims description 12
- 238000004945 emulsification Methods 0.000 claims description 12
- 230000003647 oxidation Effects 0.000 claims description 12
- 238000007254 oxidation reaction Methods 0.000 claims description 12
- 238000010792 warming Methods 0.000 claims description 12
- 229920002678 cellulose Polymers 0.000 claims description 11
- 239000001913 cellulose Substances 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 9
- 230000001376 precipitating effect Effects 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 6
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 5
- 239000002585 base Substances 0.000 claims description 5
- 229940107200 chondroitin sulfates Drugs 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 5
- 239000011593 sulfur Substances 0.000 claims description 5
- 229910052717 sulfur Inorganic materials 0.000 claims description 5
- 150000002978 peroxides Chemical class 0.000 claims description 4
- 239000012286 potassium permanganate Substances 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000003960 organic solvent Substances 0.000 abstract description 6
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 4
- 238000005265 energy consumption Methods 0.000 abstract description 3
- 230000001804 emulsifying effect Effects 0.000 abstract description 2
- 238000001914 filtration Methods 0.000 abstract 4
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 239000010419 fine particle Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 239000002932 luster Substances 0.000 description 2
- 241000251730 Chondrichthyes Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- AEMOLEFTQBMNLQ-QIUUJYRFSA-N beta-D-glucuronic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-QIUUJYRFSA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000000600 disaccharide group Chemical group 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Abstract
Description
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201110087027A CN102190740B (zh) | 2011-04-08 | 2011-04-08 | 硫酸软骨素的制备方法 |
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CN201110087027A CN102190740B (zh) | 2011-04-08 | 2011-04-08 | 硫酸软骨素的制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN102190740A CN102190740A (zh) | 2011-09-21 |
CN102190740B true CN102190740B (zh) | 2012-10-24 |
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CN201110087027A Active CN102190740B (zh) | 2011-04-08 | 2011-04-08 | 硫酸软骨素的制备方法 |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103804518A (zh) * | 2013-11-25 | 2014-05-21 | 青岛九龙生物医药有限公司 | 提高硫酸软骨素含量的制备方法 |
CN104177512B (zh) * | 2014-08-26 | 2016-04-13 | 淮安麦德森制药有限公司 | 催化法生产低分子硫酸软骨素的方法 |
CN104163877B (zh) * | 2014-08-26 | 2016-05-18 | 淮安麦德森制药有限公司 | 硫酸软骨素的制备方法 |
CN104448040A (zh) * | 2014-12-24 | 2015-03-25 | 青岛九龙生物医药有限公司 | 硫酸软骨素的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1182593A (zh) * | 1996-11-18 | 1998-05-27 | 王立杰 | 硫酸软骨素及其提取方法 |
CN1699428A (zh) * | 2005-06-29 | 2005-11-23 | 上海大学 | 硫酸软骨素的制备方法 |
CN1903889A (zh) * | 2005-07-28 | 2007-01-31 | 北京博赛斯生物技术有限公司 | 一种提取硫酸软骨素的方法 |
CN101012288A (zh) * | 2007-02-02 | 2007-08-08 | 南昌市万华生化制品有限公司 | 一种硫酸软骨素的制备方法 |
CN101824446A (zh) * | 2010-02-24 | 2010-09-08 | 淮安麦德森化学有限公司 | 反向沉淀生产硫酸软骨素的方法 |
-
2011
- 2011-04-08 CN CN201110087027A patent/CN102190740B/zh active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1182593A (zh) * | 1996-11-18 | 1998-05-27 | 王立杰 | 硫酸软骨素及其提取方法 |
CN1699428A (zh) * | 2005-06-29 | 2005-11-23 | 上海大学 | 硫酸软骨素的制备方法 |
CN1903889A (zh) * | 2005-07-28 | 2007-01-31 | 北京博赛斯生物技术有限公司 | 一种提取硫酸软骨素的方法 |
CN101012288A (zh) * | 2007-02-02 | 2007-08-08 | 南昌市万华生化制品有限公司 | 一种硫酸软骨素的制备方法 |
CN101824446A (zh) * | 2010-02-24 | 2010-09-08 | 淮安麦德森化学有限公司 | 反向沉淀生产硫酸软骨素的方法 |
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CN102190740A (zh) | 2011-09-21 |
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Denomination of invention: Preparation of chondroitin sulfate Effective date of registration: 20200819 Granted publication date: 20121024 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2020320000186 |
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Address after: 223001 No. 58, Hefei North Road, economic and Technological Development Zone, Qinghe District, Huai'an City, Jiangsu Province Patentee after: Jiangsu Madsen Pharmaceutical Co.,Ltd. Address before: 223001 No. 58, Hefei North Road, economic and Technological Development Zone, Qinghe District, Huai'an City, Jiangsu Province Patentee before: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. |
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Date of cancellation: 20211226 Granted publication date: 20121024 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: HUAIAN MAIDESEN PHARMACEUTICAL Co.,Ltd. Registration number: Y2021320000201 |
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Denomination of invention: Preparation method of chondroitin sulfate Effective date of registration: 20230206 Granted publication date: 20121024 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: Jiangsu Madsen Pharmaceutical Co.,Ltd. Registration number: Y2023320000059 |
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PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20121024 Pledgee: Huaian Qingjiang puyintai financing Company limited by guarantee Pledgor: Jiangsu Madsen Pharmaceutical Co.,Ltd. Registration number: Y2023320000059 |